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ZA200905065B - 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses - Google Patents

3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses

Info

Publication number
ZA200905065B
ZA200905065B ZA200905065A ZA200905065A ZA200905065B ZA 200905065 B ZA200905065 B ZA 200905065B ZA 200905065 A ZA200905065 A ZA 200905065A ZA 200905065 A ZA200905065 A ZA 200905065A ZA 200905065 B ZA200905065 B ZA 200905065B
Authority
ZA
South Africa
Prior art keywords
substituted
synaptic responses
glutamatergic synaptic
benzotriazinone
compounds
Prior art date
Application number
ZA200905065A
Other languages
English (en)
Inventor
Rudolf Mueller
Stephen Lee
Sean O'hare
Gary Rogers
Stan Rachwal
Leslie STREET
Original Assignee
Cortex Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortex Pharma Inc filed Critical Cortex Pharma Inc
Publication of ZA200905065B publication Critical patent/ZA200905065B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pest Control & Pesticides (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200905065A 2007-01-03 2009-07-20 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses ZA200905065B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87862607P 2007-01-03 2007-01-03

Publications (1)

Publication Number Publication Date
ZA200905065B true ZA200905065B (en) 2010-04-28

Family

ID=39608955

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200905065A ZA200905065B (en) 2007-01-03 2009-07-20 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses

Country Status (21)

Country Link
US (1) US20100041647A1 (xx)
EP (1) EP2114158B1 (xx)
JP (1) JP2010514837A (xx)
KR (1) KR20090098999A (xx)
CN (1) CN101626686A (xx)
AP (1) AP2009004915A0 (xx)
AR (1) AR064739A1 (xx)
AU (1) AU2007342364A1 (xx)
BR (1) BRPI0720323A2 (xx)
CA (1) CA2674321A1 (xx)
CO (1) CO6210740A2 (xx)
CR (1) CR10913A (xx)
EA (1) EA200900937A1 (xx)
EC (1) ECSP099538A (xx)
IL (1) IL199662A0 (xx)
MA (1) MA31159B1 (xx)
MX (1) MX2009007209A (xx)
NZ (1) NZ578290A (xx)
TN (1) TN2009000278A1 (xx)
WO (1) WO2008085505A1 (xx)
ZA (1) ZA200905065B (xx)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2144506B1 (en) * 2007-01-03 2011-10-05 Cortex Pharmaceuticals, Inc. 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses
AU2008254960B2 (en) 2007-05-17 2014-11-27 Cortex Pharmaceuticals, Inc. Di-substituted amides for enhancing glutamatergic synaptic responses
US8168632B2 (en) 2007-08-10 2012-05-01 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for the treatment of respiratory disorders
NZ583823A (en) 2007-08-10 2011-07-29 Cortex Pharma Inc Furazanes for enhancing glutamatergic synaptic responses
EA201000516A1 (ru) * 2007-09-20 2010-10-29 Кортекс Фармасеутикалс, Инк. 3-замещенные 1,2,3-триазин-4-оны и 3-замещенные 1,3-пиримидин-оны для усиления глутаматергических синаптических ответов
US20110257186A1 (en) 2010-04-15 2011-10-20 Staubli Ursula V Compositions and methods for treating visual disorders
EP2948135B1 (en) 2013-01-25 2019-01-02 Case Western Reserve University Compositions and methods for the treatment of pervasive development disorders
CN105418525B (zh) * 2015-12-16 2017-12-15 郑州轻工业学院 一种n‑取代1,2,3‑苯并三嗪‑4‑酮的制备方法
CN114716416B (zh) * 2022-04-11 2023-06-16 湖北大学 3,4-二氢吡咯衍生物及其一锅法合成
WO2024196136A1 (ko) * 2023-03-21 2024-09-26 주식회사 비보존 Mglur5 및 hdac6의 이중 조절제 및 이의 용도

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US3723436A (en) * 1971-02-25 1973-03-27 Sun Oil Co Process for aromatic lactams
FR2597103B1 (fr) * 1986-04-15 1988-12-16 Provesan Sa Procede de preparation de derives d'oxazinobenzothiazine 6,6-dioxyde
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
DE69331761T2 (de) * 1992-07-24 2002-09-12 The Regents Of The University Of California, Oakland Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US5650409A (en) * 1995-06-02 1997-07-22 Cortex Pharmaceuticals, Inc. Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) * 1996-04-03 1998-04-07 The Regents Of The University Of California Benzoxazines for enhancing synaptic response
AU4416197A (en) * 1996-09-17 1998-04-14 Regents Of The University Of California, The Positive ampa receptor modulation to enhance brain neurotrophic factor expression
US6110935A (en) * 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
US5985871A (en) * 1997-12-24 1999-11-16 Cortex Pharmaceuticals, Inc. Benzoxazine compounds for enhancing synaptic response
US6713474B2 (en) * 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
US6303542B1 (en) * 2000-08-18 2001-10-16 Rohm And Haas Company Herbicidal 3-substituted-phenyl-1,2,3-benzotriazin-4-ones
GEP20063859B (en) * 2001-11-26 2006-06-26 Cortex Pharma Inc Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses
AUPS255202A0 (en) * 2002-05-27 2002-06-13 Monash University Agents and methods for the treatment of disorders associated with motor neuron degeneration
DE10238865A1 (de) * 2002-08-24 2004-03-11 Boehringer Ingelheim International Gmbh Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
GB0317482D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
CN1897950A (zh) * 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
EP2144506B1 (en) * 2007-01-03 2011-10-05 Cortex Pharmaceuticals, Inc. 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses
AU2008254960B2 (en) * 2007-05-17 2014-11-27 Cortex Pharmaceuticals, Inc. Di-substituted amides for enhancing glutamatergic synaptic responses
EA201000516A1 (ru) * 2007-09-20 2010-10-29 Кортекс Фармасеутикалс, Инк. 3-замещенные 1,2,3-триазин-4-оны и 3-замещенные 1,3-пиримидин-оны для усиления глутаматергических синаптических ответов

Also Published As

Publication number Publication date
KR20090098999A (ko) 2009-09-18
BRPI0720323A2 (pt) 2016-08-09
CN101626686A (zh) 2010-01-13
TN2009000278A1 (en) 2010-10-18
MX2009007209A (es) 2009-10-12
ECSP099538A (es) 2009-12-28
CR10913A (es) 2009-09-21
US20100041647A1 (en) 2010-02-18
IL199662A0 (en) 2010-04-15
EP2114158A4 (en) 2010-05-05
AP2009004915A0 (en) 2009-08-31
EP2114158A1 (en) 2009-11-11
EA200900937A1 (ru) 2009-12-30
CA2674321A1 (en) 2008-07-17
JP2010514837A (ja) 2010-05-06
CO6210740A2 (es) 2010-10-20
AR064739A1 (es) 2009-04-22
WO2008085505A1 (en) 2008-07-17
EP2114158B1 (en) 2012-08-08
MA31159B1 (fr) 2010-02-01
NZ578290A (en) 2012-03-30
AU2007342364A1 (en) 2008-07-17

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