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ZA200801641B - Chromenones and their use as modulators of metabotropic glutamate receptors - Google Patents

Chromenones and their use as modulators of metabotropic glutamate receptors

Info

Publication number
ZA200801641B
ZA200801641B ZA200801641A ZA200801641A ZA200801641B ZA 200801641 B ZA200801641 B ZA 200801641B ZA 200801641 A ZA200801641 A ZA 200801641A ZA 200801641 A ZA200801641 A ZA 200801641A ZA 200801641 B ZA200801641 B ZA 200801641B
Authority
ZA
South Africa
Prior art keywords
chromenones
modulators
metabotropic glutamate
glutamate receptors
receptors
Prior art date
Application number
ZA200801641A
Inventor
Parsons Christopher Graham Raphael
Trifanova Dina
Starchenkovs Igors
Noeske Tobias
Kauss Valerjans
Jirgensons Aigars
Kalvinsh Ivars
Henrich Markus
Weil Tanja
Danysz Wojciech
Original Assignee
Merz Pharma Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa
Publication of ZA200801641B publication Critical patent/ZA200801641B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200801641A 2005-10-21 2008-02-19 Chromenones and their use as modulators of metabotropic glutamate receptors ZA200801641B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72931205P 2005-10-21 2005-10-21

Publications (1)

Publication Number Publication Date
ZA200801641B true ZA200801641B (en) 2008-12-31

Family

ID=37487556

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200801641A ZA200801641B (en) 2005-10-21 2008-02-19 Chromenones and their use as modulators of metabotropic glutamate receptors

Country Status (6)

Country Link
EP (1) EP1957475A1 (en)
AU (1) AU2006303037A1 (en)
CA (1) CA2620248A1 (en)
IL (1) IL190740A0 (en)
WO (1) WO2007045876A1 (en)
ZA (1) ZA200801641B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3231442B1 (en) 2006-06-23 2019-12-25 ADC Therapeutics SA Polynucleotides and polypeptide sequences involved in cancer
WO2009118338A2 (en) * 2008-03-27 2009-10-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of a polyphenolic type compound for preventing or treating a polyglutamine expansion neurodegenerative disease
MX2010011545A (en) 2008-04-21 2011-04-11 Otonomy Inc Auris formulations for treating otic diseases and conditions.
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
AU2009307825A1 (en) * 2008-10-22 2010-04-29 Rick FRIEDMAN Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor
WO2010060186A1 (en) 2008-11-03 2010-06-03 Alethia Biotherapeutics Inc. Antibodies that specifically block the biological activity of a tumor antigen
US8399460B2 (en) 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives
PL3173427T3 (en) 2011-03-31 2019-11-29 Adc Therapeutics Sa Antibodies against kidney associated antigen 1 and antigen binding fragments thereof
FR2973703A1 (en) * 2011-04-08 2012-10-12 Univ Provence Aix Marseille 1 4-ARYLCOUMARIN AND 4-ARYLQUINOLINE DERIVATIVES, THEIR THERAPEUTIC USES AND THEIR SYNTHESIS METHOD
AU2013209234B2 (en) 2012-01-09 2017-11-09 Adc Therapeutics Sa Method for treating breast cancer
WO2014129989A1 (en) * 2013-02-21 2014-08-28 Fargem Farmasöti̇k Araştirma Geli̇şti̇rme Merkezi̇ Sanayi̇ Ve Ti̇caret A.Ş. 3-substituted-6h-benzo[c]chromen-6-ones and 3-substituted-7,8,9,10-tetrahydro-6h-benzo[c]chromen-6-ones against senile dementia
EP2792359A1 (en) * 2013-04-19 2014-10-22 Merz Pharma GmbH & Co. KGaA Treatment of L-DOPA-induced dyskinesia with OPC-14523 or OPC-34712
JP7170341B2 (en) * 2017-09-13 2022-11-14 セレピュート インコーポレイテッド New low-molecular-weight compounds
CN110818669B (en) * 2019-11-25 2022-11-29 中国医学科学院药用植物研究所海南分所 Agarwood Tetrahydro 2-(2-Phenylethyl) Chromone Compounds and Its Separation Method and Application
CN114874174B (en) * 2022-02-25 2023-09-22 云南民族大学 Chromans with anti-hepatitis B virus and coronavirus effects
CN119818480A (en) * 2024-12-19 2025-04-15 皖南医学院 Application of 7-hydroxy-4-methylcoumarin and its analogs in the preparation of drugs for inhibiting Parthanatos cell death

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1158264C (en) * 1997-11-21 2004-07-21 Nps药物有限公司 Metabotropic glutamate receptor antagonists for the treatment of central nervous system disorders
EP1408042A4 (en) * 2001-06-14 2005-02-02 Banyu Pharma Co Ltd NOVEL ISOXAZOLOPYRIDONE DERIVATIVES AND THEIR USE
TWI301760B (en) * 2004-02-27 2008-10-11 Merz Pharma Gmbh & Co Kgaa Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors

Also Published As

Publication number Publication date
EP1957475A1 (en) 2008-08-20
WO2007045876A1 (en) 2007-04-26
AU2006303037A1 (en) 2007-04-26
CA2620248A1 (en) 2007-04-26
IL190740A0 (en) 2009-09-22

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