ZA200800266B - Compositions to improve the bioavailability of polymethoxyflavones and tocotrienols for the treatment of cardiovascular disease - Google Patents
Compositions to improve the bioavailability of polymethoxyflavones and tocotrienols for the treatment of cardiovascular diseaseInfo
- Publication number
- ZA200800266B ZA200800266B ZA200800266A ZA200800266A ZA200800266B ZA 200800266 B ZA200800266 B ZA 200800266B ZA 200800266 A ZA200800266 A ZA 200800266A ZA 200800266 A ZA200800266 A ZA 200800266A ZA 200800266 B ZA200800266 B ZA 200800266B
- Authority
- ZA
- South Africa
- Prior art keywords
- polymethoxyflavones
- tocotrienols
- bioavailability
- compositions
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69472005P | 2005-06-28 | 2005-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200800266B true ZA200800266B (en) | 2009-08-26 |
Family
ID=37596076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200800266A ZA200800266B (en) | 2005-06-28 | 2006-06-28 | Compositions to improve the bioavailability of polymethoxyflavones and tocotrienols for the treatment of cardiovascular disease |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20070111953A1 (xx) |
| EP (1) | EP1907007A2 (xx) |
| JP (1) | JP2008546845A (xx) |
| KR (2) | KR20080081807A (xx) |
| AU (1) | AU2006263577B2 (xx) |
| CA (1) | CA2613803A1 (xx) |
| IL (1) | IL188449A0 (xx) |
| WO (1) | WO2007002897A2 (xx) |
| ZA (1) | ZA200800266B (xx) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080166418A1 (en) * | 2007-01-04 | 2008-07-10 | Sones Scott F | Krill oil compositions |
| WO2009055867A1 (en) * | 2007-10-31 | 2009-05-07 | The University Of Sydney | Treatment of metabolic disease |
| JP5596317B2 (ja) * | 2009-08-18 | 2014-09-24 | 静岡県公立大学法人 | 心疾患予防治療剤 |
| KR101340675B1 (ko) * | 2011-12-05 | 2013-12-12 | 대구한의대학교산학협력단 | 탄제레틴을 포함하는 심혈관계 질환의 예방 또는 치료용 약학 조성물 |
| US9132117B2 (en) | 2013-06-17 | 2015-09-15 | Kgk Synergize, Inc | Compositions and methods for glycemic control of subjects with impaired fasting glucose |
| DE202023001978U1 (de) | 2023-09-20 | 2023-09-29 | Penta Phi Eg | Formulierung umfassend Coenzym Q10 und Kreatin |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59137421A (ja) * | 1983-01-28 | 1984-08-07 | Naganoken Kooridoufu Kogyo Kyodo Kumiai | 生理活性物質の製造法 |
| US5217992A (en) * | 1989-10-04 | 1993-06-08 | Bristol-Myers Squibb Company | Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders |
| JPH09255570A (ja) * | 1996-03-21 | 1997-09-30 | Fujitsuko Kk | 血中脂質濃度を低減させる薬剤及び可食性組成物 |
| US6251400B1 (en) * | 1997-09-26 | 2001-06-26 | Kgk Synergize Inc | Compositions and methods of treatment of neoplastic diseases and hypercholesterolemia with citrus limonoids and flavonoids and tocotrienols |
| US20010055627A1 (en) * | 1997-09-26 | 2001-12-27 | Najla Guthrie | Compositions And Methods For Regulating Lipoproteins And Hypercholesterolemia With Limonoids, Flavonoids And Tocotrienols |
| US6312703B1 (en) * | 1998-02-06 | 2001-11-06 | Lecigel, Llc | Compressed lecithin preparations |
| US20020127259A1 (en) * | 1998-02-06 | 2002-09-12 | Orthoefer Frand T. | Rumen by-pass delivery system |
| US6987125B1 (en) * | 1998-10-06 | 2006-01-17 | The United States Of America As Represented By The Secretary Of Agriculture | Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones |
| JP2003504327A (ja) * | 1999-07-08 | 2003-02-04 | プレンダーガスト、パトリック、ティ. | 感染症の治療を目的としたフラボン類、クマリン類および関連化合物の使用 |
| JP4012735B2 (ja) * | 2001-10-09 | 2007-11-21 | 笑子 金城 | シークワーサー果皮精油高含有物の抽出方法及びその粉末 |
| US20030144219A1 (en) * | 2001-11-15 | 2003-07-31 | Phinney Stephen Dodge | Formulations and methods for treatment or amelioration of inflammatory conditions |
| JP2005518381A (ja) * | 2001-12-19 | 2005-06-23 | ザ キグリー コーポレーション | 抹消神経・血管疾患の治療方法 |
| WO2003077904A1 (en) * | 2002-03-15 | 2003-09-25 | Nichimo Co., Ltd. | Biological activity-promoting compositions containing soybean germ-origin isoflavone aglycon |
| DE10217557A1 (de) * | 2002-04-19 | 2003-11-06 | Degussa Bioactives Gmbh | Funktionsnahrungsmittel enthaltend eine Phospholipid-haltige stabile Matrix |
| DE10217555A1 (de) * | 2002-04-19 | 2004-02-19 | Degussa Bioactives Deutschland Gmbh | Physiologisch verträgliche, Phospholipid-haltige, stabile und harte Matrix |
| JP4599604B2 (ja) * | 2002-04-19 | 2010-12-15 | カーギル テクスチュアライジング ソリューションズ ドイチュラント ゲゼルシャフト ミット ベシュレクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト | 生体活性のリン脂質含有成分を含有するマトリックス |
-
2006
- 2006-06-28 WO PCT/US2006/025588 patent/WO2007002897A2/en not_active Ceased
- 2006-06-28 CA CA002613803A patent/CA2613803A1/en not_active Abandoned
- 2006-06-28 KR KR1020077031028A patent/KR20080081807A/ko not_active Ceased
- 2006-06-28 US US11/478,970 patent/US20070111953A1/en not_active Abandoned
- 2006-06-28 EP EP06785970A patent/EP1907007A2/en not_active Withdrawn
- 2006-06-28 AU AU2006263577A patent/AU2006263577B2/en not_active Ceased
- 2006-06-28 ZA ZA200800266A patent/ZA200800266B/xx unknown
- 2006-06-28 JP JP2008519613A patent/JP2008546845A/ja active Pending
- 2006-06-28 KR KR1020137009648A patent/KR20130046451A/ko not_active Ceased
-
2007
- 2007-12-27 IL IL188449A patent/IL188449A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006263577B2 (en) | 2015-08-06 |
| EP1907007A2 (en) | 2008-04-09 |
| KR20080081807A (ko) | 2008-09-10 |
| KR20130046451A (ko) | 2013-05-07 |
| WO2007002897A2 (en) | 2007-01-04 |
| US20070111953A1 (en) | 2007-05-17 |
| JP2008546845A (ja) | 2008-12-25 |
| WO2007002897A3 (en) | 2007-06-07 |
| WO2007002897A8 (en) | 2007-04-19 |
| IL188449A0 (en) | 2008-04-13 |
| CA2613803A1 (en) | 2007-01-04 |
| AU2006263577A1 (en) | 2007-01-04 |
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