ZA200808817B - Dialkylphenyl compounds having ß2 adrenergic receptor agonist and muscarinic receptor antagonist activity - Google Patents
Dialkylphenyl compounds having ß2 adrenergic receptor agonist and muscarinic receptor antagonist activityInfo
- Publication number
- ZA200808817B ZA200808817B ZA200808817A ZA200808817A ZA200808817B ZA 200808817 B ZA200808817 B ZA 200808817B ZA 200808817 A ZA200808817 A ZA 200808817A ZA 200808817 A ZA200808817 A ZA 200808817A ZA 200808817 B ZA200808817 B ZA 200808817B
- Authority
- ZA
- South Africa
- Prior art keywords
- antagonist activity
- receptor antagonist
- receptor agonist
- dialkylphenyl
- compounds
- Prior art date
Links
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 title 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 title 1
- 239000000048 adrenergic agonist Substances 0.000 title 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 title 1
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 239000003149 muscarinic antagonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79470206P | 2006-04-25 | 2006-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200808817B true ZA200808817B (en) | 2010-03-31 |
Family
ID=38577470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200808817A ZA200808817B (en) | 2006-04-25 | 2008-10-15 | Dialkylphenyl compounds having ß2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7524965B2 (xx) |
| EP (1) | EP2010489B1 (xx) |
| JP (1) | JP2009541209A (xx) |
| KR (1) | KR20090005389A (xx) |
| CN (1) | CN101426764A (xx) |
| AR (1) | AR060647A1 (xx) |
| AU (1) | AU2007243481A1 (xx) |
| BR (1) | BRPI0710767A2 (xx) |
| CA (1) | CA2650530A1 (xx) |
| CO (1) | CO6140054A2 (xx) |
| ES (1) | ES2391584T3 (xx) |
| IL (1) | IL194334A0 (xx) |
| MA (1) | MA30556B1 (xx) |
| MX (1) | MX2008013555A (xx) |
| NO (1) | NO20084603L (xx) |
| PE (1) | PE20080094A1 (xx) |
| RU (1) | RU2008146383A (xx) |
| TW (1) | TW200811105A (xx) |
| WO (1) | WO2007127196A2 (xx) |
| ZA (1) | ZA200808817B (xx) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6693202B1 (en) * | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| TWI341836B (en) | 2004-03-11 | 2011-05-11 | Theravance Inc | Biphenyl compounds useful as muscarinic receptor antagonists |
| EP1778626A1 (en) * | 2004-08-16 | 2007-05-02 | Theravance, Inc. | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| TW200811104A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Crystalline forms of a dimethylphenyl compound |
| TW200811105A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| PL2242759T3 (pl) * | 2008-02-06 | 2013-06-28 | Astrazeneca Ab | Związki |
| ES2417339T3 (es) | 2009-04-23 | 2013-08-07 | Theravance, Inc. | Compuestos de diamina que tienen actividad antagonista del receptor muscarinico y agonista del receptor beta2-adrenergico |
| US10265311B2 (en) | 2009-07-22 | 2019-04-23 | PureTech Health LLC | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| PL3061821T3 (pl) | 2009-07-22 | 2020-01-31 | PureTech Health LLC | Kompozycje do leczenia zaburzeń łagodzonych przez aktywację receptora muskarynowego |
| WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
| GB201009801D0 (en) | 2010-06-11 | 2010-07-21 | Astrazeneca Ab | Compounds 950 |
| JP7096441B2 (ja) | 2018-09-28 | 2022-07-05 | カルナ セラピューティックス，インコーポレイテッド | ムスカリン受容体活性化によって改善される障害を処置するための組成物及び方法 |
| CN114409556B (zh) * | 2022-01-28 | 2024-10-18 | 兰州康鹏威耳化工有限公司 | 一种3,4-二取代-2-氨基苯甲醛的制备方法 |
| CN117924216A (zh) * | 2024-01-12 | 2024-04-26 | 王叔和生物医药(武汉)有限公司 | 一种1-哌啶丙酸的合成方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7545894A (en) | 1993-09-02 | 1995-03-22 | Yamanouchi Pharmaceutical Co., Ltd. | Carbamate derivative and medicine containing the same |
| EP0747355A4 (en) | 1994-02-10 | 1997-04-09 | Yamanouchi Pharma Co Ltd | NEW CARBAMATES AND MEDICINAL PRODUCTS CONTAINING THEM |
| US6040344A (en) | 1996-11-11 | 2000-03-21 | Sepracor Inc. | Formoterol process |
| US6362371B1 (en) * | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| DE19921693A1 (de) | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| UA73965C2 (en) | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
| US7045658B2 (en) * | 2001-03-22 | 2006-05-16 | Glaxo Group Limited | Formailide derivatives as beta2-adrenoreceptor agonists |
| US20030018019A1 (en) | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
| TWI249515B (en) | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| ES2329586T3 (es) | 2003-11-21 | 2009-11-27 | Theravance, Inc. | Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino. |
| EP1723110A1 (en) | 2004-03-11 | 2006-11-22 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
| TWI374883B (en) | 2004-08-16 | 2012-10-21 | Theravance Inc | Crystalline form of a biphenyl compound |
| WO2006023460A2 (en) | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| EP1778626A1 (en) | 2004-08-16 | 2007-05-02 | Theravance, Inc. | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| TW200811105A (en) | 2006-04-25 | 2008-03-01 | Theravance Inc | Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| TW200811104A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Crystalline forms of a dimethylphenyl compound |
-
2007
- 2007-04-23 TW TW096114175A patent/TW200811105A/zh unknown
- 2007-04-24 AR ARP070101777A patent/AR060647A1/es unknown
- 2007-04-24 CN CNA2007800140984A patent/CN101426764A/zh active Pending
- 2007-04-24 AU AU2007243481A patent/AU2007243481A1/en not_active Abandoned
- 2007-04-24 ES ES07776093T patent/ES2391584T3/es active Active
- 2007-04-24 BR BRPI0710767-6A patent/BRPI0710767A2/pt not_active IP Right Cessation
- 2007-04-24 WO PCT/US2007/009925 patent/WO2007127196A2/en not_active Ceased
- 2007-04-24 EP EP07776093A patent/EP2010489B1/en active Active
- 2007-04-24 PE PE2007000509A patent/PE20080094A1/es not_active Application Discontinuation
- 2007-04-24 JP JP2009507757A patent/JP2009541209A/ja active Pending
- 2007-04-24 KR KR1020087028589A patent/KR20090005389A/ko not_active Withdrawn
- 2007-04-24 RU RU2008146383/04A patent/RU2008146383A/ru not_active Application Discontinuation
- 2007-04-24 CA CA002650530A patent/CA2650530A1/en not_active Abandoned
- 2007-04-24 MX MX2008013555A patent/MX2008013555A/es active IP Right Grant
- 2007-04-24 US US11/789,300 patent/US7524965B2/en active Active
-
2008
- 2008-09-25 IL IL194334A patent/IL194334A0/en unknown
- 2008-10-15 ZA ZA200808817A patent/ZA200808817B/xx unknown
- 2008-10-29 CO CO08115666A patent/CO6140054A2/es unknown
- 2008-10-30 NO NO20084603A patent/NO20084603L/no not_active Application Discontinuation
- 2008-11-14 MA MA31382A patent/MA30556B1/fr unknown
-
2009
- 2009-03-18 US US12/406,283 patent/US7687521B2/en active Active
-
2010
- 2010-02-05 US US12/701,108 patent/US8134006B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7524965B2 (en) | 2009-04-28 |
| JP2009541209A (ja) | 2009-11-26 |
| EP2010489A2 (en) | 2009-01-07 |
| IL194334A0 (en) | 2009-08-03 |
| TW200811105A (en) | 2008-03-01 |
| PE20080094A1 (es) | 2008-02-17 |
| AU2007243481A1 (en) | 2007-11-08 |
| US7687521B2 (en) | 2010-03-30 |
| WO2007127196A3 (en) | 2007-12-21 |
| MX2008013555A (es) | 2008-11-04 |
| CO6140054A2 (es) | 2010-03-19 |
| US20090176833A1 (en) | 2009-07-09 |
| RU2008146383A (ru) | 2010-05-27 |
| US20070249675A1 (en) | 2007-10-25 |
| CN101426764A (zh) | 2009-05-06 |
| MA30556B1 (fr) | 2009-07-01 |
| EP2010489B1 (en) | 2012-08-22 |
| NO20084603L (no) | 2008-11-19 |
| AR060647A1 (es) | 2008-07-02 |
| US20100137603A1 (en) | 2010-06-03 |
| WO2007127196A2 (en) | 2007-11-08 |
| CA2650530A1 (en) | 2007-11-08 |
| ES2391584T3 (es) | 2012-11-28 |
| US8134006B2 (en) | 2012-03-13 |
| KR20090005389A (ko) | 2009-01-13 |
| BRPI0710767A2 (pt) | 2011-06-07 |
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