[go: up one dir, main page]

ZA200703110B - Compounds, compositions and methods of inhibiting α-synuclein toxicity - Google Patents

Compounds, compositions and methods of inhibiting α-synuclein toxicity

Info

Publication number
ZA200703110B
ZA200703110B ZA200703110A ZA200703110A ZA200703110B ZA 200703110 B ZA200703110 B ZA 200703110B ZA 200703110 A ZA200703110 A ZA 200703110A ZA 200703110 A ZA200703110 A ZA 200703110A ZA 200703110 B ZA200703110 B ZA 200703110B
Authority
ZA
South Africa
Prior art keywords
compositions
compounds
methods
inhibiting
synuclein
Prior art date
Application number
ZA200703110A
Other languages
English (en)
Inventor
Susan L Lindquist
Outeiro Tiago
Labaudiniere Richard
Original Assignee
Whitehead Biomedical Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Biomedical Inst filed Critical Whitehead Biomedical Inst
Publication of ZA200703110B publication Critical patent/ZA200703110B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA200703110A 2004-09-17 2007-04-16 Compounds, compositions and methods of inhibiting α-synuclein toxicity ZA200703110B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61079604P 2004-09-17 2004-09-17

Publications (1)

Publication Number Publication Date
ZA200703110B true ZA200703110B (en) 2008-08-27

Family

ID=36090510

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200703110A ZA200703110B (en) 2004-09-17 2007-04-16 Compounds, compositions and methods of inhibiting α-synuclein toxicity

Country Status (13)

Country Link
US (1) US8440705B2 (xx)
EP (2) EP2433634A3 (xx)
JP (1) JP5001843B2 (xx)
CN (2) CN102379872A (xx)
AT (1) ATE531367T1 (xx)
AU (1) AU2005287137B2 (xx)
BR (1) BRPI0515549A (xx)
CA (1) CA2580767A1 (xx)
ES (1) ES2376108T3 (xx)
NO (1) NO20071860L (xx)
NZ (4) NZ584773A (xx)
WO (1) WO2006034003A2 (xx)
ZA (1) ZA200703110B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ570103A (en) * 2006-01-26 2011-11-25 Foldrx Pharmaceuticals Inc Compounds and methods for modulating protein trafficking
MX2008014898A (es) * 2006-05-24 2009-04-22 Univ Nagasaki Composicion para el diagnostico de enfermedades relacionadas con amiloides.
WO2008025152A1 (en) * 2006-08-28 2008-03-06 Mcmaster University Antibacterial agents
EP2513090A1 (en) * 2009-12-16 2012-10-24 Neuropore Therapies, Inc. Compound suitable for the treatment of synucleopathies
DK2592934T3 (en) 2010-07-16 2015-10-26 Nivalis Therapeutics Inc NOVEL dihydropyridin-2 (1H) -one compounds as S-NITROSOGLUTATHIONREDUKTASEINHIBITORER and neurokinin-3 receptor antagonists
US20130158035A1 (en) * 2010-08-24 2013-06-20 Brigham Young University Antimetastatic compounds
US20130196990A1 (en) 2010-10-06 2013-08-01 Junya Qu Benzimidazole Derivatives As PI3 Kinase Inhibitors
US9815845B2 (en) 2010-10-13 2017-11-14 Trustees Of Boston University Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics
CN103347520A (zh) * 2010-10-13 2013-10-09 波士顿大学管理委员会 用作癌症化学治疗的晚期sv40因子（lsf）的抑制剂
US9802948B2 (en) 2010-10-13 2017-10-31 Trustees Of Boston Univeristy Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics
EP2635907A4 (en) 2010-11-05 2014-04-16 Univ Brandeis ICE-COLDED ALPHA SYNNUCLEINE A BIOMARKERS
US9175001B2 (en) * 2011-10-02 2015-11-03 Trustees Of Boston University [1,3] dioxolo [4,5-g] [1,2,4] triazolo [1,5-a] quinoline derivatives as inhibitors of the late SV40 factor (LSF) for use in treating cancer
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
BR112015023533A2 (pt) 2013-03-15 2017-10-24 Whitehead Inst Biomedical Res plataforma de descoberta celular para doenças neurodegenerativas
EP3174872A1 (en) * 2014-07-29 2017-06-07 Université de Lille 2 Droit et Santé 2-oxo-3,4-dihydropyridine-5-carboxylates and their use
WO2016040794A1 (en) 2014-09-12 2016-03-17 Whitehead Institute For Biomedical Research Cells expressing apolipoprotein e and uses thereof
GB201509663D0 (en) * 2015-06-03 2015-07-15 Johnson Matthey Plc Benzo(h)quinoline ligands and complexes thereof
AU2017246476B2 (en) * 2016-04-08 2021-08-05 Baylor College Of Medicine Small molecule regulators of steroid receptor coactivators and methods of use thereof
US11110080B2 (en) 2017-03-27 2021-09-07 The Regents Of The University Of Colorado, A Body Corporate Small molecule inhibitors of bacterial efflux pumps and methods of using same
WO2019074898A1 (en) * 2017-10-09 2019-04-18 Alsatech, Inc. DISAGGREGATION OF ALPHA-SYNUCLEIN WITH SMALL MOLECULES
US11420977B2 (en) 2018-08-02 2022-08-23 Trustees Of Boston University Late SV40 (LSF) inhibitors
EP3947370A4 (en) * 2019-03-28 2022-12-28 1st Biotherapeutics, Inc. Pharmaceutical salts of benzothiazol compounds, polymorphs and methods for preparation thereof
US11242353B2 (en) 2020-01-24 2022-02-08 Trustees Of Boston University Heterocyclic LSF inhibitors and their uses
CN112062770A (zh) * 2020-08-21 2020-12-11 台州学院 一种稠环二氢吡啶酮的制备方法
WO2022051388A2 (en) 2020-09-01 2022-03-10 Trustees Of Boston University Quinolin-2(1h)-one inhibitors of late sv40 factor
EP4638427A1 (en) * 2022-12-22 2025-10-29 Université Côte d'Azur Amidinourea derivatives and their use in the treatment of cancer

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US610796A (en) 1898-09-13 Bicycle air-brake
GB158076A (xx) *
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
BE757938A (fr) * 1969-10-23 1971-04-23 Bayer Ag Nouveaux benzothiazylamides d'acides cyclopropane- carboxylique, leur procede de preparation et leur application comme herbicides
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
JPS5516149B2 (xx) * 1972-01-14 1980-04-30
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
USRE28819E (en) 1972-12-08 1976-05-18 Syntex (U.S.A.) Inc. Dialkylated glycol compositions and medicament preparations containing same
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
DE2418913A1 (de) 1974-04-19 1975-10-30 Sueddeutsche Kalkstickstoff Verfahren zur herstellung von 2-benzthiazolylguanidin
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4410545A (en) 1981-02-13 1983-10-18 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4328245A (en) 1981-02-13 1982-05-04 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4358603A (en) 1981-04-16 1982-11-09 Syntex (U.S.A.) Inc. Acetal stabilized prostaglandin compositions
US4409239A (en) 1982-01-21 1983-10-11 Syntex (U.S.A.) Inc. Propylene glycol diester solutions of PGE-type compounds
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4710384A (en) 1986-07-28 1987-12-01 Avner Rotman Sustained release tablets made from microcapsules
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
US5308857A (en) * 1988-08-15 1994-05-03 Fujisawa Pharmaceutical Co., Ltd. Furylthiazole derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
IT1228293B (it) * 1989-02-06 1991-06-07 Angeli Inst Spa Benzoderivati di composti eterociclici contenenti azoto.
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
IL95548A0 (en) * 1989-09-15 1991-06-30 Fujisawa Pharmaceutical Co Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
IT1246382B (it) 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5543390A (en) 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US6010715A (en) 1992-04-01 2000-01-04 Bertek, Inc. Transdermal patch incorporating a polymer film incorporated with an active agent
US6024975A (en) 1992-04-08 2000-02-15 Americare International Diagnostics, Inc. Method of transdermally administering high molecular weight drugs with a polymer skin enhancer
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US6274552B1 (en) 1993-03-18 2001-08-14 Cytimmune Sciences, Inc. Composition and method for delivery of biologically-active factors
US5985307A (en) 1993-04-14 1999-11-16 Emory University Device and method for non-occlusive localized drug delivery
US5523092A (en) 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
US6004534A (en) 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US5759542A (en) 1994-08-05 1998-06-02 New England Deaconess Hospital Corporation Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
US5660854A (en) 1994-11-28 1997-08-26 Haynes; Duncan H Drug releasing surgical implant or dressing material
US5983134A (en) 1995-04-23 1999-11-09 Electromagnetic Bracing Systems Inc. Electrophoretic cuff apparatus drug delivery system
US6316652B1 (en) 1995-06-06 2001-11-13 Kosta Steliou Drug mitochondrial targeting agents
US6167301A (en) 1995-08-29 2000-12-26 Flower; Ronald J. Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit
US6039975A (en) 1995-10-17 2000-03-21 Hoffman-La Roche Inc. Colon targeted delivery system
TW349948B (en) * 1995-10-31 1999-01-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 2-quinolone derivatives
TW345603B (en) 1996-05-29 1998-11-21 Gmundner Fertigteile Gmbh A noise control device for tracks
US5985317A (en) 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
JP2000508339A (ja) 1996-10-01 2000-07-04 シーマ・ラブス・インコーポレイテッド 味隠蔽マイクロカプセル組成物及び製造方法
US6131570A (en) 1998-06-30 2000-10-17 Aradigm Corporation Temperature controlling device for aerosol drug delivery
SI0951466T1 (sl) 1996-12-23 2009-10-31 Elan Pharm Inc Cikloalkili, laktami, laktoni in sorodne spojine, farmacevtske zmesi, ki jih vsebujejo, in metode inhibicije sproščanja beta-amiloidnega peptida in/ali njegove sinteze z uporabo takih spojin
US5860957A (en) 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
HRP980093A2 (en) 1997-02-28 1998-12-31 Lilly Co Eli Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting "beta"-amyloid peptide release and/or its synthesis by use of such compounds
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6060082A (en) 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
US5948433A (en) 1997-08-21 1999-09-07 Bertek, Inc. Transdermal patch
AU730850B2 (en) 1997-10-28 2001-03-15 Bando Chemical Industries, Ltd. A transdermal patch and a method for manufacture of a substrate sheet therefor
US6506782B1 (en) 1998-02-27 2003-01-14 Athena Neurosciences, Inc. Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6048736A (en) 1998-04-29 2000-04-11 Kosak; Kenneth M. Cyclodextrin polymers for carrying and releasing drugs
US6569851B1 (en) * 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
GB9823873D0 (en) * 1998-10-30 1998-12-30 Pharmacia & Upjohn Spa 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents
US6271359B1 (en) 1999-04-14 2001-08-07 Musc Foundation For Research Development Tissue-specific and pathogen-specific toxic agents and ribozymes
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6261595B1 (en) 2000-02-29 2001-07-17 Zars, Inc. Transdermal drug patch with attached pocket for controlled heating device
ES2254836T3 (es) 2000-06-05 2006-06-16 Austria Wirtschaftsservice Gesellschaft Mit Beschrankter Haftung Hidrazonas heterociclicas como principios activos anticancerosos.
CA2415815A1 (en) * 2000-07-06 2002-01-17 Nigel H. Greig Tetrahydrobenzothiazole analogues as neuroprotective agents
ATE382704T1 (de) 2001-02-15 2008-01-15 Univ Chicago Verfahren zum nachweis in hefe für mittels die proteinfaltung beeinflussen
CA2473441A1 (en) 2002-01-18 2003-07-24 The Genetics Company Inc. Beta-secretase inhibitors
AU2003211385A1 (en) * 2002-02-28 2003-09-09 Takeda Chemical Industries, Ltd. Azole compounds
DK1511710T3 (en) * 2002-05-31 2014-02-24 Proteotech Inc RELATIONSHIPS, PREPARATIONS AND METHODS FOR TREATING AMYLOID DISEASES AND SYNUCLEINOPATHES, SUCH AS ALZHEIMER'S DISEASE, TYPE 2-DIABETES AND PARKINSON'S DISEASE
WO2004093790A2 (en) 2003-04-16 2004-11-04 Whitehead Institute For Biomedical Research Yeast ectopically expressing abnormally processed proteins and uses therefor
WO2005030128A2 (en) * 2003-09-23 2005-04-07 Merck & Co., Inc. Pyrazole modulators of metabotropic glutamate receptors
NZ570103A (en) * 2006-01-26 2011-11-25 Foldrx Pharmaceuticals Inc Compounds and methods for modulating protein trafficking
JP4876867B2 (ja) * 2006-11-27 2012-02-15 株式会社Ｉｈｉ ターボ圧縮機のロータ

Also Published As

Publication number Publication date
NZ584773A (en) 2012-07-27
NZ554545A (en) 2010-10-29
NZ588431A (en) 2012-02-24
US20080261953A1 (en) 2008-10-23
EP2433634A2 (en) 2012-03-28
EP2433634A3 (en) 2012-07-18
BRPI0515549A (pt) 2008-07-29
AU2005287137B2 (en) 2012-03-22
EP1802303A4 (en) 2009-12-16
CA2580767A1 (en) 2006-03-30
NZ588432A (en) 2012-03-30
HK1105893A1 (en) 2008-02-29
JP5001843B2 (ja) 2012-08-15
NO20071860L (no) 2007-06-05
WO2006034003A2 (en) 2006-03-30
WO2006034003A3 (en) 2006-07-13
EP1802303B1 (en) 2011-11-02
CN102379872A (zh) 2012-03-21
AU2005287137A1 (en) 2006-03-30
JP2008513471A (ja) 2008-05-01
CN101060839A (zh) 2007-10-24
ATE531367T1 (de) 2011-11-15
ES2376108T3 (es) 2012-03-09
US8440705B2 (en) 2013-05-14
EP1802303A2 (en) 2007-07-04

Similar Documents

Publication Publication Date Title
ZA200703110B (en) Compounds, compositions and methods of inhibiting α-synuclein toxicity
WO2007126841A3 (en) Inhibition of alpha-synuclein toxicity
EA200702358A1 (ru) Комбинация ингибитора pde4 и производного тетрагидробиоптерина
LTC1830843I2 (lt) Indolidono dariniai, skirti fibrozinių ligų gydymui arba prevencijai
EP1854415A4 (en) SURGICAL TREATMENT DEVICE
NO20081016L (no) Nye 1-aryl-3-azabicyklo(3.1.0)heksaner, fremstilling og bruk for å behandle nevropsykiatriske lidelser
CY2014028I1 (el) Ενωσεις, φαρμακοτεχνικες μορφες και μεθοδοι θεραπειας ή αποτροπhς ροδοχρωμης ακμης
AP2359A (en) Sulfonamide derivatives for the treatment of diseases.
NO20076241L (no) Terapier for vaskulaere sykdommer
DE602005022427D1 (de) Verwendung von flibanserin bei der behandlung von prämenstruellen störungen
DE602006002982D1 (de) Verwendung von 3,11b-cis-dihydrotetrabenazin zur behandlung von symptomen der huntington-krankheit
EA200601837A1 (ru) Бензоксазины для лечения заболеваний дыхательных путей
NO20053947D0 (no) Forbedrede antitumorale behandlinger.
EP1942884A4 (en) METHOD FOR THE TREATMENT OF CANCER WITH SAHA, CARBOPLATIN AND PACLITAXEL AND OTHER COMBINATION THERAPIES
DE602006003094D1 (de) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinolin-derivate zur behandlung von unfruchtbarkeit
ITRM20050179A1 (it) Composizione impiegabile per il trattamento delle patologie paradontali.
IL185653A (en) Antibodies that call for the 1-kim salt region
DE602006002608D1 (de) 4-phenyl-5-oxo-l,4,5,6,7,8-hexahydrochinolin-derivate als arzneimittel zur behandlung von unfruchtbarkeit
DE602004004937D1 (de) Medizinischer Artikel auf Basis von syndiotaktischem 1,2-Polybutadien
WO2006127966A3 (en) Compositions and methods for enhancing axon regeneration
EP1755637A4 (en) METHOD FOR PREVENTING OR TREATING BONE DISORDERS
RU2007134729A (ru) Применение электросудорожной терапии для лечения игровой завимости
EP1743639A8 (en) Use of substituted pyrazoline compounds for the treatment of coagulation related diseases
ES1058402Y (es) Panteon perfeccionado.
ITPD20050092U1 (it) Dispositivo per la facilitazione del gioco cosidetto sudoku