ZA200702317B - Methods for preparing indazole compounds - Google Patents
Methods for preparing indazole compoundsInfo
- Publication number
- ZA200702317B ZA200702317B ZA200702317A ZA200702317A ZA200702317B ZA 200702317 B ZA200702317 B ZA 200702317B ZA 200702317 A ZA200702317 A ZA 200702317A ZA 200702317 A ZA200702317 A ZA 200702317A ZA 200702317 B ZA200702317 B ZA 200702317B
- Authority
- ZA
- South Africa
- Prior art keywords
- methods
- indazole compounds
- preparing indazole
- preparing
- compounds
- Prior art date
Links
- 125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62457504P | 2004-11-02 | 2004-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200702317B true ZA200702317B (en) | 2008-09-25 |
Family
ID=35528034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200702317A ZA200702317B (en) | 2004-11-02 | 2007-03-20 | Methods for preparing indazole compounds |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1809625A1 (en) |
| JP (1) | JP2008518901A (en) |
| KR (1) | KR20070058689A (en) |
| CN (1) | CN101044138A (en) |
| AR (1) | AR051753A1 (en) |
| AU (1) | AU2005300311A1 (en) |
| BR (1) | BRPI0517921A (en) |
| CA (1) | CA2586176A1 (en) |
| IL (1) | IL182096A0 (en) |
| MX (1) | MX2007003603A (en) |
| NO (1) | NO20072747L (en) |
| RU (1) | RU2007114112A (en) |
| TW (1) | TW200614990A (en) |
| WO (1) | WO2006048745A1 (en) |
| ZA (1) | ZA200702317B (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2073803B1 (en) | 2006-10-12 | 2018-09-19 | Astex Therapeutics Limited | Pharmaceutical combinations |
| US8883790B2 (en) | 2006-10-12 | 2014-11-11 | Astex Therapeutics Limited | Pharmaceutical combinations |
| PT2134702T (en) | 2007-04-05 | 2017-07-31 | Pfizer Prod Inc | 6- [2- (METHYLARBAMOYL) PHENYLSULPHANYL] -3-E- [2- (PYRIDIN-2-YL) ETENYL] INDAZOLE CRYSTALLINE FORM FOR THE TREATMENT OF FREQUENT CELL GROWTH IN MAMMALS |
| US8354528B2 (en) | 2007-10-25 | 2013-01-15 | Genentech, Inc. | Process for making thienopyrimidine compounds |
| EP2163544A1 (en) * | 2008-09-16 | 2010-03-17 | Pfizer, Inc. | Methods of preparing indazole compounds |
| AU2012313885A1 (en) | 2011-09-30 | 2014-03-13 | Pfizer Inc. | Pharmaceutical compositions of N-methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide |
| BR112014011453A2 (en) | 2011-11-11 | 2017-05-02 | Pfizer | n-methyl-2- [3 - ((e) -2-pyridin-2-yl-vinyl) -1h-indazol-6-ylsulfanyl] -benzamide for the treatment of chronic myelogenous leukemia |
| EP2792360A1 (en) | 2013-04-18 | 2014-10-22 | IP Gesellschaft für Management mbH | (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV |
| CN103387565B (en) * | 2013-07-29 | 2014-10-29 | 苏州明锐医药科技有限公司 | The preparation method of Axitinib |
| CN103570696B (en) * | 2013-11-06 | 2016-02-24 | 湖南欧亚生物有限公司 | A kind of preparation method of Axitinib intermediate and preparing the application in Axitinib |
| WO2015067224A1 (en) | 2013-11-08 | 2015-05-14 | Zentiva, K.S. | Salts of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethanyl] indazole |
| EP3498734B1 (en) | 2014-02-04 | 2021-09-01 | Pfizer Inc. | Combination of a pd-1 antagonist and a vegfr inhibitor for treating cancer |
| RU2667486C2 (en) * | 2014-03-31 | 2018-09-20 | Сэндзю Фармацевтикал Ко., Лтд. | Alkynyl indazole derivative and use thereof |
| CN104072484B (en) * | 2014-07-07 | 2016-07-06 | 渤海大学 | Nitrogen-(4-(aromatic thiohydroxy)-1 hydrogen-indazole-3-base)-1-(heteroaromatic replacement) methylene imine compounds and pharmaceutically acceptable salt and its preparation method and application thereof |
| CA2955676A1 (en) | 2014-08-25 | 2016-03-03 | Pfizer Inc. | Combination of a pd-1 antagonist and an alk inhibitor for treating cancer |
| WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| RU2714233C2 (en) | 2015-02-26 | 2020-02-13 | Мерк Патент Гмбх | Pd-1/pd-l1 inhibitors for treating cancer |
| US9580406B2 (en) | 2015-04-28 | 2017-02-28 | Signa S.A. De C.V. | Processes for the preparation of axitinib |
| AU2016280003B2 (en) | 2015-06-16 | 2021-09-16 | Merck Patent Gmbh | PD-L1 antagonist combination treatments |
| MX2019003755A (en) | 2016-10-06 | 2019-08-12 | Pfizer | Dosing regimen of avelumab for the treatment of cancer. |
| US20220370606A1 (en) | 2018-12-21 | 2022-11-24 | Pfizer Inc. | Combination Treatments Of Cancer Comprising A TLR Agonist |
| EA202192731A1 (en) | 2019-04-18 | 2022-02-04 | Синтон Б.В. | METHOD FOR PRODUCING AXITINIB, METHOD FOR PURIFYING 2-((3-IODO-1H-INDAZOL-6-YL)THIO)-N-METHYLBENZAMIDE INTERMEDIATE, METHOD FOR PURIFYING AXITINIB THROUGH HCl AXITINIB SALT, SOLID FORM OF AXITINIB SALT HCl |
| CN112209861A (en) * | 2019-07-11 | 2021-01-12 | 鲁南制药集团股份有限公司 | Acixtinib intermediate compound and preparation method thereof |
| CN112442010B (en) * | 2019-08-30 | 2023-10-03 | 润佳（苏州）医药科技有限公司 | Prodrug compounds and application thereof in treating cancers |
| CN111440102B (en) * | 2020-04-26 | 2022-02-15 | 大连凯飞化学股份有限公司 | Preparation method of dithiodibenzoamide compound |
| IL315262A (en) | 2022-03-03 | 2024-10-01 | Pfizer | Multispecific antibodies binding to il-4, il-13 and/or tslp and uses thereof |
| CN114591338B (en) * | 2022-03-31 | 2023-05-09 | 苏州欧康维视生物科技有限公司 | Preparation method and application of Syk and VEGFR2 double-target inhibitor |
| WO2025157389A1 (en) | 2024-01-22 | 2025-07-31 | Iomx Therapeutics Ag | Combinations of halogenated heterocyclic kinase inhibitors and vegfr inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20010306A1 (en) * | 1999-07-02 | 2001-03-29 | Agouron Pharma | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM USEFUL FOR THE INHIBITION OF PROTEIN KINASE |
| KR100730267B1 (en) * | 2002-12-19 | 2007-06-20 | 화이자 인코포레이티드 | 2-1h-indazol-6-ylamino-benzamide compounds as protein kinases inhibitors useful for the treatment of ophtalmic diseases |
| CA2517517C (en) * | 2003-03-03 | 2012-12-18 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| WO2005094823A1 (en) * | 2004-03-30 | 2005-10-13 | Kyowa Hakko Kogyo Co., Ltd. | Flt-3 INHIBITOR |
-
2005
- 2005-10-21 RU RU2007114112/04A patent/RU2007114112A/en not_active Application Discontinuation
- 2005-10-21 JP JP2007538538A patent/JP2008518901A/en not_active Withdrawn
- 2005-10-21 WO PCT/IB2005/003300 patent/WO2006048745A1/en not_active Ceased
- 2005-10-21 MX MX2007003603A patent/MX2007003603A/en unknown
- 2005-10-21 BR BRPI0517921-1A patent/BRPI0517921A/en not_active IP Right Cessation
- 2005-10-21 EP EP05796299A patent/EP1809625A1/en not_active Withdrawn
- 2005-10-21 CN CNA2005800361530A patent/CN101044138A/en active Pending
- 2005-10-21 AU AU2005300311A patent/AU2005300311A1/en not_active Abandoned
- 2005-10-21 KR KR1020077009804A patent/KR20070058689A/en not_active Ceased
- 2005-10-21 CA CA002586176A patent/CA2586176A1/en not_active Abandoned
- 2005-11-01 AR ARP050104567A patent/AR051753A1/en not_active Application Discontinuation
- 2005-11-01 TW TW094138224A patent/TW200614990A/en unknown
-
2007
- 2007-03-20 ZA ZA200702317A patent/ZA200702317B/en unknown
- 2007-03-21 IL IL182096A patent/IL182096A0/en unknown
- 2007-05-30 NO NO20072747A patent/NO20072747L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1809625A1 (en) | 2007-07-25 |
| CA2586176A1 (en) | 2006-05-11 |
| AU2005300311A1 (en) | 2006-05-11 |
| TW200614990A (en) | 2006-05-16 |
| NO20072747L (en) | 2007-07-31 |
| IL182096A0 (en) | 2007-07-24 |
| WO2006048745A1 (en) | 2006-05-11 |
| RU2007114112A (en) | 2008-12-10 |
| MX2007003603A (en) | 2007-05-21 |
| KR20070058689A (en) | 2007-06-08 |
| AR051753A1 (en) | 2007-02-07 |
| BRPI0517921A (en) | 2008-10-21 |
| JP2008518901A (en) | 2008-06-05 |
| CN101044138A (en) | 2007-09-26 |
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