ZA200701612B - Cyclopropyl piperidine glycine transporter inhibitors - Google Patents
Cyclopropyl piperidine glycine transporter inhibitorsInfo
- Publication number
- ZA200701612B ZA200701612B ZA200701612A ZA200701612A ZA200701612B ZA 200701612 B ZA200701612 B ZA 200701612B ZA 200701612 A ZA200701612 A ZA 200701612A ZA 200701612 A ZA200701612 A ZA 200701612A ZA 200701612 B ZA200701612 B ZA 200701612B
- Authority
- ZA
- South Africa
- Prior art keywords
- glycine transporter
- cyclopropyl piperidine
- transporter inhibitors
- piperidine glycine
- cyclopropyl
- Prior art date
Links
- 102000010726 Glycine Plasma Membrane Transport Proteins Human genes 0.000 title abstract 3
- 108010063380 Glycine Plasma Membrane Transport Proteins Proteins 0.000 title abstract 3
- JUBXTBVKELTJEX-UHFFFAOYSA-N 1-cyclopropylpiperidine Chemical compound C1CC1N1CCCCC1 JUBXTBVKELTJEX-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 102100023145 Sodium- and chloride-dependent glycine transporter 1 Human genes 0.000 abstract 2
- 101710083171 Sodium- and chloride-dependent glycine transporter 1 Proteins 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 230000024587 synaptic transmission, glutamatergic Effects 0.000 abstract 1
- 230000027682 synaptic transmission, glycinergic Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61494204P | 2004-09-30 | 2004-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200701612B true ZA200701612B (en) | 2009-05-27 |
Family
ID=36142986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200701612A ZA200701612B (en) | 2004-09-30 | 2007-02-23 | Cyclopropyl piperidine glycine transporter inhibitors |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7776886B2 (xx) |
| EP (1) | EP1797035B1 (xx) |
| JP (1) | JP4646984B2 (xx) |
| KR (1) | KR20070058565A (xx) |
| CN (1) | CN101031547A (xx) |
| AT (1) | ATE488501T1 (xx) |
| AU (1) | AU2005292323B2 (xx) |
| BR (1) | BRPI0515954A (xx) |
| CA (1) | CA2581582C (xx) |
| DE (1) | DE602005024838D1 (xx) |
| IL (1) | IL182253A0 (xx) |
| MX (1) | MX2007003816A (xx) |
| NO (1) | NO20072208L (xx) |
| RU (1) | RU2387644C2 (xx) |
| WO (1) | WO2006039221A2 (xx) |
| ZA (1) | ZA200701612B (xx) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007512251A (ja) * | 2003-11-12 | 2007-05-17 | メルク エンド カムパニー インコーポレーテッド | ４−フェニルピペリジンスルホニルグリシン輸送体インヒビター |
| JP4756031B2 (ja) * | 2004-03-24 | 2011-08-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ヘテロアリールピペリジングリシン輸送体インヒビター |
| AU2005243192A1 (en) * | 2004-04-29 | 2005-11-24 | Merck & Co., Inc. | Azetidine glycine transporter inhibitors |
| US7576083B2 (en) * | 2004-05-05 | 2009-08-18 | Merck & Co., Inc. | Morpholinyl piperidine glycine transporter inhibitors |
| DE602005022764D1 (de) * | 2004-12-21 | 2010-09-16 | Merck Sharp & Dohme | Piperidin- und azetidinderivate als glyt1-inhibitoren |
| AU2006256583B2 (en) * | 2005-06-06 | 2012-01-12 | Merck Sharp & Dohme Limited | Cyclohexanesulfonyl derivatives as GlyT1 inhibitors to treat schizophrenia |
| JP5340729B2 (ja) | 2005-06-13 | 2013-11-13 | メルク シャープ エンド ドーム リミテッド | 治療剤 |
| AU2006309050B2 (en) * | 2005-10-28 | 2012-08-16 | Merck Sharp & Dohme Corp. | Piperidine glycine transporter inhibitors |
| US8431700B2 (en) | 2009-03-03 | 2013-04-30 | Vanderbilt University | Alkylsulfonyl-2,3-dihydrospiro[indene-1,4′-piperidine] analogs as GlyT1 inhibitors, methods for making same, and use of same in treating psychiatric disorders |
| WO2015164520A1 (en) | 2014-04-24 | 2015-10-29 | Dart Neuroscience, Llc | Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c] pyrazole and 4,5,6,7-tetrahydro-2h-pyrazolo [4,3-c] pyridine compounds as glyt1 inhibitors |
| US10040759B2 (en) | 2014-11-05 | 2018-08-07 | Dart Neuroscience (Cayman) Ltd. | Substituted azetidinyl compounds as GlyT1 inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5532237A (en) | 1995-02-15 | 1996-07-02 | Merck Frosst Canada, Inc. | Indole derivatives with affinity for the cannabinoid receptor |
| US6303637B1 (en) * | 1998-10-30 | 2001-10-16 | Merck & Co., Inc. | Heterocyclic potassium channel inhibitors |
| JP4664564B2 (ja) * | 2000-03-06 | 2011-04-06 | アカディア ファーマシューティカルズ，インコーポレーテッド | セロトニン関連疾患の治療に使用する含窒素環式化合物 |
| EP1268449A4 (en) * | 2000-03-23 | 2004-09-15 | Merck & Co Inc | SUBSTITUTED PIPERIDINE AS MELANOCORTIN RECEPTOR AGONISTS |
| US7507767B2 (en) | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
| EP1444203A1 (en) | 2001-11-14 | 2004-08-11 | Schering Corporation | Cannabinoid receptor ligands |
| GB0130696D0 (en) | 2001-12-21 | 2002-02-06 | Smithkline Beecham Plc | Chemical Compounds |
| TW200403058A (en) | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| JP2007512251A (ja) | 2003-11-12 | 2007-05-17 | メルク エンド カムパニー インコーポレーテッド | ４−フェニルピペリジンスルホニルグリシン輸送体インヒビター |
| JP4756031B2 (ja) * | 2004-03-24 | 2011-08-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ヘテロアリールピペリジングリシン輸送体インヒビター |
| AU2005243192A1 (en) * | 2004-04-29 | 2005-11-24 | Merck & Co., Inc. | Azetidine glycine transporter inhibitors |
| US7576083B2 (en) | 2004-05-05 | 2009-08-18 | Merck & Co., Inc. | Morpholinyl piperidine glycine transporter inhibitors |
| DE602005022764D1 (de) | 2004-12-21 | 2010-09-16 | Merck Sharp & Dohme | Piperidin- und azetidinderivate als glyt1-inhibitoren |
| AU2006256583B2 (en) | 2005-06-06 | 2012-01-12 | Merck Sharp & Dohme Limited | Cyclohexanesulfonyl derivatives as GlyT1 inhibitors to treat schizophrenia |
| EP1942733B1 (en) | 2005-09-29 | 2012-03-21 | Merck Sharp & Dohme Corp. | Radiolabeled glycine transporter inhibitors |
| AU2006309050B2 (en) | 2005-10-28 | 2012-08-16 | Merck Sharp & Dohme Corp. | Piperidine glycine transporter inhibitors |
-
2005
- 2005-09-26 RU RU2007116165/04A patent/RU2387644C2/ru not_active IP Right Cessation
- 2005-09-26 AT AT05801197T patent/ATE488501T1/de not_active IP Right Cessation
- 2005-09-26 WO PCT/US2005/034301 patent/WO2006039221A2/en not_active Ceased
- 2005-09-26 KR KR1020077007362A patent/KR20070058565A/ko not_active Withdrawn
- 2005-09-26 CA CA2581582A patent/CA2581582C/en not_active Expired - Lifetime
- 2005-09-26 US US11/664,190 patent/US7776886B2/en active Active
- 2005-09-26 BR BRPI0515954-7A patent/BRPI0515954A/pt not_active IP Right Cessation
- 2005-09-26 CN CNA2005800331179A patent/CN101031547A/zh active Pending
- 2005-09-26 DE DE602005024838T patent/DE602005024838D1/de not_active Expired - Lifetime
- 2005-09-26 JP JP2007534679A patent/JP4646984B2/ja not_active Expired - Fee Related
- 2005-09-26 AU AU2005292323A patent/AU2005292323B2/en not_active Ceased
- 2005-09-26 EP EP05801197A patent/EP1797035B1/en not_active Expired - Lifetime
- 2005-09-26 MX MX2007003816A patent/MX2007003816A/es active IP Right Grant
-
2007
- 2007-02-23 ZA ZA200701612A patent/ZA200701612B/xx unknown
- 2007-03-27 IL IL182253A patent/IL182253A0/en unknown
- 2007-04-27 NO NO20072208A patent/NO20072208L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007003816A (es) | 2007-04-24 |
| BRPI0515954A (pt) | 2008-08-12 |
| EP1797035B1 (en) | 2010-11-17 |
| EP1797035A2 (en) | 2007-06-20 |
| CN101031547A (zh) | 2007-09-05 |
| WO2006039221A2 (en) | 2006-04-13 |
| WO2006039221A3 (en) | 2006-09-08 |
| JP4646984B2 (ja) | 2011-03-09 |
| IL182253A0 (en) | 2007-09-20 |
| AU2005292323A1 (en) | 2006-04-13 |
| EP1797035A4 (en) | 2009-08-05 |
| CA2581582A1 (en) | 2006-04-13 |
| US20080108663A1 (en) | 2008-05-08 |
| RU2387644C2 (ru) | 2010-04-27 |
| US7776886B2 (en) | 2010-08-17 |
| CA2581582C (en) | 2010-07-20 |
| NO20072208L (no) | 2007-04-27 |
| KR20070058565A (ko) | 2007-06-08 |
| JP2008514705A (ja) | 2008-05-08 |
| DE602005024838D1 (en) | 2010-12-30 |
| RU2007116165A (ru) | 2008-11-10 |
| AU2005292323B2 (en) | 2011-06-09 |
| ATE488501T1 (de) | 2010-12-15 |
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