ZA200701582B - Oxazolo-naphtyl acids as plasminogen activator inhibitor type-1 (PAI-1) modulators useful in the treatment of thrombosis and cardiovascular - Google Patents
Oxazolo-naphtyl acids as plasminogen activator inhibitor type-1 (PAI-1) modulators useful in the treatment of thrombosis and cardiovascularInfo
- Publication number
- ZA200701582B ZA200701582B ZA200701582A ZA200701582A ZA200701582B ZA 200701582 B ZA200701582 B ZA 200701582B ZA 200701582 A ZA200701582 A ZA 200701582A ZA 200701582 A ZA200701582 A ZA 200701582A ZA 200701582 B ZA200701582 B ZA 200701582B
- Authority
- ZA
- South Africa
- Prior art keywords
- oxazolo
- naphtyl
- pai
- thrombosis
- cardiovascular
- Prior art date
Links
- 102000010752 Plasminogen Inactivators Human genes 0.000 title 1
- 108010077971 Plasminogen Inactivators Proteins 0.000 title 1
- 208000007536 Thrombosis Diseases 0.000 title 1
- 230000002526 effect on cardiovascular system Effects 0.000 title 1
- 239000002797 plasminogen activator inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60373604P | 2004-08-23 | 2004-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200701582B true ZA200701582B (en) | 2009-09-30 |
Family
ID=35431452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200701582A ZA200701582B (en) | 2004-08-23 | 2007-02-22 | Oxazolo-naphtyl acids as plasminogen activator inhibitor type-1 (PAI-1) modulators useful in the treatment of thrombosis and cardiovascular |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7754747B2 (xx) |
| EP (1) | EP1781645A1 (xx) |
| JP (1) | JP2008510815A (xx) |
| KR (1) | KR20070055563A (xx) |
| CN (1) | CN101039936A (xx) |
| AU (1) | AU2005277138A1 (xx) |
| BR (1) | BRPI0514544A (xx) |
| CA (1) | CA2577857A1 (xx) |
| CR (1) | CR8930A (xx) |
| EC (1) | ECSP077269A (xx) |
| IL (1) | IL181331A0 (xx) |
| MX (1) | MX2007002178A (xx) |
| NO (1) | NO20071379L (xx) |
| RU (1) | RU2007106868A (xx) |
| WO (1) | WO2006023865A1 (xx) |
| ZA (1) | ZA200701582B (xx) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003297787A1 (en) * | 2002-12-10 | 2004-06-30 | Wyeth | Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| BRPI0514549A (pt) * | 2004-08-23 | 2008-06-17 | Wyeth Corp | ácidos de pirrol-naftila como inibidores de pai-1 |
| WO2006023866A2 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1 |
| CA2617372A1 (en) * | 2005-08-17 | 2007-02-22 | Wyeth | Substituted indoles and use thereof |
| MX2008011015A (es) * | 2006-02-27 | 2008-11-14 | Wyeth Corp | Inhibidores de pai-1 para tratamiento de afecciones musculares. |
| WO2007149395A2 (en) * | 2006-06-20 | 2007-12-27 | Amphora Discovery Corporation | 2,5-substituted oxazole derivatives as protein kinase inhibitors for the treatment of cancer |
| KR20180032686A (ko) * | 2010-03-24 | 2018-03-30 | 아미텍 테러퓨틱 솔루션즈 인크 | 인산화효소 억제에 유용한 헤테로환 화합물 |
| CN106890324A (zh) * | 2015-12-18 | 2017-06-27 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗糖尿病肾病的方法 |
| CA3008686C (en) | 2015-12-18 | 2023-03-14 | Talengen International Limited | Method for preventing and treating diabetic nephropathy |
| US11311607B2 (en) | 2016-12-15 | 2022-04-26 | Talengen International Limited | Method for making glucagon and insulin restore normal balance |
| US20230305023A1 (en) | 2020-06-25 | 2023-09-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of treatment and diagnostic of pathological conditions associated with intense stress |
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-
2005
- 2005-08-22 RU RU2007106868/04A patent/RU2007106868A/ru not_active Application Discontinuation
- 2005-08-22 EP EP05788587A patent/EP1781645A1/en not_active Withdrawn
- 2005-08-22 KR KR1020077006737A patent/KR20070055563A/ko not_active Withdrawn
- 2005-08-22 CA CA002577857A patent/CA2577857A1/en not_active Abandoned
- 2005-08-22 MX MX2007002178A patent/MX2007002178A/es not_active Application Discontinuation
- 2005-08-22 US US11/208,777 patent/US7754747B2/en not_active Expired - Fee Related
- 2005-08-22 WO PCT/US2005/029823 patent/WO2006023865A1/en not_active Ceased
- 2005-08-22 JP JP2007530022A patent/JP2008510815A/ja not_active Withdrawn
- 2005-08-22 CN CNA2005800351098A patent/CN101039936A/zh active Pending
- 2005-08-22 BR BRPI0514544-9A patent/BRPI0514544A/pt not_active IP Right Cessation
- 2005-08-22 AU AU2005277138A patent/AU2005277138A1/en not_active Abandoned
-
2007
- 2007-02-14 IL IL181331A patent/IL181331A0/en unknown
- 2007-02-15 CR CR8930A patent/CR8930A/es not_active Application Discontinuation
- 2007-02-22 ZA ZA200701582A patent/ZA200701582B/xx unknown
- 2007-02-23 EC EC2007007269A patent/ECSP077269A/es unknown
- 2007-03-14 NO NO20071379A patent/NO20071379L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101039936A (zh) | 2007-09-19 |
| US7754747B2 (en) | 2010-07-13 |
| RU2007106868A (ru) | 2008-09-27 |
| CA2577857A1 (en) | 2006-03-02 |
| CR8930A (es) | 2007-08-28 |
| ECSP077269A (es) | 2007-03-29 |
| IL181331A0 (en) | 2007-07-04 |
| AU2005277138A1 (en) | 2006-03-02 |
| NO20071379L (no) | 2007-04-16 |
| EP1781645A1 (en) | 2007-05-09 |
| MX2007002178A (es) | 2007-04-02 |
| WO2006023865A1 (en) | 2006-03-02 |
| BRPI0514544A (pt) | 2008-06-17 |
| JP2008510815A (ja) | 2008-04-10 |
| KR20070055563A (ko) | 2007-05-30 |
| US20060052348A1 (en) | 2006-03-09 |
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