ZA200610416B - Indole derivatives as histamine receptor antagonists - Google Patents

Indole derivatives as histamine receptor antagonists

Info

Publication number: ZA200610416B
Authority: ZA; South Africa
Prior art keywords: receptor antagonists; indole derivatives; histamine receptor; histamine; indole
Prior art date: 2004-06-21

Application number

ZA200610416A

Other languages

English (en)

Inventor

Mcarthur Silvia Gatti

Nettekoven Matthias Heinrich

Roche Oliver

Schuler Franz

Hertel Cornelia

Raab Susanne

Rosa Maria Rodriguez-Sarmiento

Plancher Jean-Marc

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-21

Filing date

2006-12-12

Publication date

2008-09-25

2006-12-12 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-09-25 Publication of ZA200610416B publication Critical patent/ZA200610416B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Obesity (AREA)
Diabetes (AREA)
Hematology (AREA)
Psychology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Addiction (AREA)
Cardiology (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

ZA200610416A 2004-06-21 2006-12-12 Indole derivatives as histamine receptor antagonists ZA200610416B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP04102839		2004-06-21

Publications (1)

Publication Number	Publication Date
ZA200610416B true ZA200610416B (en)	2008-09-25

Family

ID=34982342

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200610416A ZA200610416B (en)	2004-06-21	2006-12-12	Indole derivatives as histamine receptor antagonists

Country Status (23)

Country	Link
US (1)	US7361682B2 (xx)
EP (1)	EP1761519B1 (xx)
JP (1)	JP4652404B2 (xx)
CN (1)	CN1972926B (xx)
AR (1)	AR049696A1 (xx)
AT (1)	ATE394391T1 (xx)
AU (1)	AU2005254658B2 (xx)
BR (1)	BRPI0512335A (xx)
CA (1)	CA2569611C (xx)
DE (1)	DE602005006567D1 (xx)
DK (1)	DK1761519T3 (xx)
ES (1)	ES2306170T3 (xx)
IL (1)	IL179737A (xx)
MX (1)	MXPA06014810A (xx)
MY (1)	MY139941A (xx)
NO (1)	NO20070336L (xx)
NZ (1)	NZ551663A (xx)
PL (1)	PL1761519T3 (xx)
PT (1)	PT1761519E (xx)
RU (1)	RU2382778C2 (xx)
TW (1)	TW200612936A (xx)
WO (1)	WO2005123716A1 (xx)
ZA (1)	ZA200610416B (xx)

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CN101107227B (zh)	2005-01-19	2010-09-22	霍夫曼-拉罗奇有限公司	5-氨基吲哚衍生物
BRPI0619268A2 (pt) *	2005-11-30	2011-09-20	Hoffmann La Roche	compostos, processo para a sua manufatura, composições farmacêuticas, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, uso dos compostos e método para o tratamento ou prevenção de obesidade e de diabetes do tipo ii em um ser humano ou animal
EP1968967B1 (en)	2005-11-30	2011-04-27	F. Hoffmann-La Roche AG	1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators
EP1960383B1 (en) *	2005-11-30	2010-04-28	F. Hoffmann-la Roche AG	5-substituted indole-2-carboxamide derivatives
CA2647440A1 (en)	2006-04-12	2007-10-18	Matthias Nettekoven	5-amido-2-carboxamide indoles
US7432255B2 (en) *	2006-05-16	2008-10-07	Hoffmann-La Roche Inc.	1H-indol-5-yl-piperazin-1-yl-methanone derivatives
US7514433B2 (en) *	2006-08-03	2009-04-07	Hoffmann-La Roche Inc.	1H-indole-6-yl-piperazin-1-yl-methanone derivatives
EP2684871B1 (en)	2006-12-19	2016-05-04	F. Hoffmann-La Roche AG	Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives
EP2079694B1 (en)	2006-12-28	2017-03-01	Rigel Pharmaceuticals, Inc.	N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
US7507736B2 (en)	2007-02-07	2009-03-24	Hoffmann-La Roche Inc.	Indol-2-yl-piperazin-1-yl-methanone derivatives
US7648979B2 (en)	2007-02-07	2010-01-19	Hoffmann-La Roche Inc.	5-amido-(1H-indol-2-yl)-piperazin-1-yl-methanone derivatives
US7557108B2 (en) *	2007-02-07	2009-07-07	Hoffmann-La Roche Inc.	(Indol-4-yl) or (indol-5-yl)-piperazinylmethanones
CA2679670A1 (en) *	2007-03-01	2008-09-12	Janssen Pharmaceutica N.V.	Indole and benzothiophene compounds as modulators of the histamine h3 receptor
CA2693207A1 (en) *	2007-07-25	2009-01-29	F. Hoffmann-La Roche Ag	Benzofuran- and benzo[b]thiophene-2-carboxylic acid amide derivatives and use thereof as histamine 3 receptor modulators
WO2009028618A1 (ja) *	2007-08-31	2009-03-05	Astellas Pharma Inc.	ピペリジン誘導体
MX2010005298A (es)	2007-11-16	2010-06-30	Rigel Pharmaceuticals Inc	Compuestos de carboxamida, sulfonamida y amina para trastornos metabolicos.
EP2231666B1 (en)	2007-12-12	2015-07-29	Rigel Pharmaceuticals, Inc.	Carboxamide, sulfonamide and amine compounds for metabolic disorders
AU2009240643B2 (en)	2008-04-23	2014-03-06	Rigel Pharmaceuticals, Inc.	Carboxamide compounds for the treatment of metabolic disorders
US20100035862A1 (en) *	2008-06-25	2010-02-11	Abbott Laboratories	Novel aza-cyclic indole-2-carboxamides and methods of use thereof
FR2950053B1 (fr) *	2009-09-11	2014-08-01	Fournier Lab Sa	Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson
HRP20161167T1 (hr) *	2012-08-23	2016-11-04	Suven Life Sciences Limited	Spoj akrilamida kao ligandi histaminskog h3 receptora
EP2722329A1 (en) *	2012-10-18	2014-04-23	F. Hoffmann-La Roche AG	Indol-amide compounds as beta-amyloid inhbitors
KR101551313B1 (ko) *	2014-07-28	2015-09-09	충남대학교산학협력단	신규한 인덴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 망막 질환의 예방 또는 치료용 약학적 조성물
CN106065008B (zh) *	2016-06-16	2018-06-05	黑龙江中医药大学	一种具有改善睡眠作用的吲哚-2-酰胺类化合物及其应用
EP3582783B1 (en)	2017-02-17	2023-06-07	Trevena, Inc.	7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
US11702408B2 (en)	2017-02-17	2023-07-18	Trevena, Inc.	5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same

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FR2705095B1 (fr) *	1993-05-12	1995-06-23	Adir	Nouveaux indoles substitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
ES2241194T3 (es) *	1997-12-24	2005-10-16	Aventis Pharma Deutschland Gmbh	Derivados de indol en calidad de inhibidores de factor xa.
EP0978512A1 (en) *	1998-07-29	2000-02-09	Societe Civile Bioprojet	Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications
ATE430730T1 (de) *	2000-03-31	2009-05-15	Ortho Mcneil Pharm Inc	Phenyl-substituierte indole als h3 histaminrezeptorantagonisten
HU227197B1 (en) *	2000-10-24	2010-10-28	Richter Gedeon Nyrt	Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
JP4544820B2 (ja) *	2001-03-09	2010-09-15	オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド	複素環化合物
US6673829B2 (en) *	2001-09-14	2004-01-06	Novo Nordisk A/S	Aminoazetidine,-pyrrolidine and -piperidine derivatives
MXPA05000193A (es) *	2002-06-24	2005-04-08	Schering Corp	Derivados de indol utiles como antagonistas de la histamina h2.

2005
- 2005-06-13 DK DK05756581T patent/DK1761519T3/da active
- 2005-06-13 MX MXPA06014810A patent/MXPA06014810A/es active IP Right Grant
- 2005-06-13 JP JP2007517135A patent/JP4652404B2/ja not_active Expired - Fee Related
- 2005-06-13 EP EP05756581A patent/EP1761519B1/en not_active Expired - Lifetime
- 2005-06-13 RU RU2007102224/04A patent/RU2382778C2/ru not_active IP Right Cessation
- 2005-06-13 WO PCT/EP2005/006303 patent/WO2005123716A1/en not_active Ceased
- 2005-06-13 NZ NZ551663A patent/NZ551663A/en unknown
- 2005-06-13 DE DE602005006567T patent/DE602005006567D1/de not_active Expired - Lifetime
- 2005-06-13 PL PL05756581T patent/PL1761519T3/pl unknown
- 2005-06-13 CN CN2005800204455A patent/CN1972926B/zh not_active Expired - Fee Related
- 2005-06-13 ES ES05756581T patent/ES2306170T3/es not_active Expired - Lifetime
- 2005-06-13 AT AT05756581T patent/ATE394391T1/de active
- 2005-06-13 AU AU2005254658A patent/AU2005254658B2/en not_active Ceased
- 2005-06-13 CA CA2569611A patent/CA2569611C/en not_active Expired - Fee Related
- 2005-06-13 PT PT05756581T patent/PT1761519E/pt unknown
- 2005-06-13 BR BRPI0512335-6A patent/BRPI0512335A/pt not_active IP Right Cessation
- 2005-06-17 AR ARP050102510A patent/AR049696A1/es not_active Application Discontinuation
- 2005-06-20 TW TW094120464A patent/TW200612936A/zh unknown
- 2005-06-20 MY MYPI20052800A patent/MY139941A/en unknown
- 2005-06-20 US US11/157,093 patent/US7361682B2/en not_active Expired - Fee Related
2006
- 2006-11-30 IL IL179737A patent/IL179737A/en not_active IP Right Cessation
- 2006-12-12 ZA ZA200610416A patent/ZA200610416B/xx unknown
2007
- 2007-01-18 NO NO20070336A patent/NO20070336L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1972926B (zh)	2011-02-16
BRPI0512335A (pt)	2008-03-04
WO2005123716A1 (en)	2005-12-29
AU2005254658B2 (en)	2011-06-16
TW200612936A (en)	2006-05-01
MY139941A (en)	2009-11-30
PT1761519E (pt)	2008-07-02
DK1761519T3 (da)	2008-07-21
US7361682B2 (en)	2008-04-22
IL179737A0 (en)	2007-05-15
EP1761519B1 (en)	2008-05-07
NZ551663A (en)	2009-09-25
IL179737A (en)	2011-12-29
MXPA06014810A (es)	2007-02-12
JP4652404B2 (ja)	2011-03-16
JP2008503511A (ja)	2008-02-07
AR049696A1 (es)	2006-08-30
RU2382778C2 (ru)	2010-02-27
RU2007102224A (ru)	2008-07-27
ATE394391T1 (de)	2008-05-15
EP1761519A1 (en)	2007-03-14
PL1761519T3 (pl)	2008-09-30
DE602005006567D1 (de)	2008-06-19
US20050282864A1 (en)	2005-12-22
NO20070336L (no)	2007-02-13
CN1972926A (zh)	2007-05-30
CA2569611C (en)	2012-12-11
CA2569611A1 (en)	2005-12-29
AU2005254658A1 (en)	2005-12-29
ES2306170T3 (es)	2008-11-01

Publication	Publication Date	Title
IL179737A0 (en)	2007-05-15	Indole derivatives as histamine receptor antagonists
ZA200800320B (en)	2009-02-25	Indol-3-carbonyl-spiro-piperidine derivatives as Via receptor antagonists
ZA200700683B (en)	2008-08-27	Piperidine derivatives as histamine H3 receptor ligands
IL165863A0 (en)	2006-01-15	Indole derivatives useful as histamine H3 antagonists
ZA200705085B (en)	2008-08-27	2,3,4,9-Tetrahydro-1H-carbazole derivatives as CRTH2 receptor antagonists
IL189453A0 (en)	2008-08-07	Carboxamide derivatives as muscarinic receptor antagonists
SI1636206T1 (sl)	2008-02-29	Imidazolni derivati kot antagonisti receptorja glutamata
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