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ZA200500086B - Novel carboxamide compounds having an MCH-antagonistic effect, medicaments containing said compounds, and method for the production thereof - Google Patents

Novel carboxamide compounds having an MCH-antagonistic effect, medicaments containing said compounds, and method for the production thereof

Info

Publication number
ZA200500086B
ZA200500086B ZA200500086A ZA200500086A ZA200500086B ZA 200500086 B ZA200500086 B ZA 200500086B ZA 200500086 A ZA200500086 A ZA 200500086A ZA 200500086 A ZA200500086 A ZA 200500086A ZA 200500086 B ZA200500086 B ZA 200500086B
Authority
ZA
South Africa
Prior art keywords
compounds
mch
production
antagonistic effect
medicaments containing
Prior art date
Application number
ZA200500086A
Other languages
English (en)
Inventor
Thorsten Lehmann-Lintz
Martin Lenter
Klaus Rudolf
Ralf H Lotz
Philipp Lustenberger
Dirk Stenkam
Heike-Andre Wieland
Stephan Mueller
Kirsten Arndt
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of ZA200500086B publication Critical patent/ZA200500086B/xx

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • A61P13/00—Drugs for disorders of the urinary system
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    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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ZA200500086A 2002-08-24 2005-01-05 Novel carboxamide compounds having an MCH-antagonistic effect, medicaments containing said compounds, and method for the production thereof ZA200500086B (en)

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Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351719B2 (en) 2002-10-31 2008-04-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
WO2004072018A1 (ja) 2003-02-12 2004-08-26 Takeda Pharmaceutical Company Limited アミン誘導体
CA2540826A1 (en) 2003-10-01 2005-04-14 The Procter & Gamble Company Melanin concentrating hormone antagonists
JP4667384B2 (ja) * 2003-10-07 2011-04-13 レノビス， インコーポレイテッド イオンチャネルリガンドとしてのアミド誘導体および薬学的組成物、ならびにこれらを使用する方法
US7592373B2 (en) 2003-12-23 2009-09-22 Boehringer Ingelheim International Gmbh Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
US7605176B2 (en) 2004-03-06 2009-10-20 Boehringer Ingelheim International Gmbh β-ketoamide compounds with MCH antagonistic activity
US7524862B2 (en) 2004-04-14 2009-04-28 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
DE102004017934A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
AU2005247164B2 (en) * 2004-05-25 2008-11-27 Pfizer Products Inc. Specific PPAR agonists for treating negative energy balance
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
DE102004039789A1 (de) * 2004-08-16 2006-03-02 Sanofi-Aventis Deutschland Gmbh Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7968574B2 (en) 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
AU2005321966B2 (en) 2004-12-28 2011-11-17 Atnx Spv, Llc Compositions and methods of treating cell proliferation disorders
WO2007021309A1 (en) * 2005-08-12 2007-02-22 Astrazeneca Ab Substituted isoindolones and their use as metabotropic glutamate receptor potentiators
US7807706B2 (en) 2005-08-12 2010-10-05 Astrazeneca Ab Metabotropic glutamate-receptor-potentiating isoindolones
CN101341135B (zh) 2005-12-21 2013-08-14 詹森药业有限公司 治疗mch-1介导的疾病的取代的吡嗪酮衍生物
TW200804347A (en) 2006-01-10 2008-01-16 Janssen Pharmaceutica Nv Urotensin II receptor antagonists
WO2007093363A1 (en) * 2006-02-15 2007-08-23 Sanofi-Aventis Novel azacycly-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments
BRPI0707870A2 (pt) * 2006-02-15 2011-05-10 Sanofi Aventis ariltienopirimidinonas substituÍdas com amino Álcool, processo para sua preparaÇço e seu uso como medicamentos
KR20080094699A (ko) 2006-02-15 2008-10-23 사노피-아벤티스 신규 아미노알콜-치환된 아릴디하이드로이소퀴놀리논, 이의제조 방법 및 이의 약물로서의 용도
KR20080095877A (ko) * 2006-02-15 2008-10-29 사노피-아벤티스 아자사이클릴-치환된 아릴디하이드로이소퀴놀리논, 이의 제조 방법 및 약제로서 이의 용도
JP5564251B2 (ja) * 2006-06-29 2014-07-30 キネックス ファーマシューティカルズ， エルエルシー キナーゼカスケードを調節するためのビアリール組成物および方法
TWI398440B (zh) * 2006-06-29 2013-06-11 Kinex Pharmaceuticals Llc 雙芳基組成物與調節激酶級聯之方法
JP5379000B2 (ja) 2006-07-31 2013-12-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ウロテンシンｉｉ受容体アンタゴニスト
RU2453543C2 (ru) 2006-08-25 2012-06-20 Бёрингер Ингельхайм Интернациональ Гмбх Новые производные пиридона, обладающие антагонистической активностью в отношении mch, и лекарственные средства, включающие такие соединения
MX2009005908A (es) 2006-12-05 2009-06-16 Janssen Pharmaceutica Nv Derivados novedosos de diaza-espiro-piridinona sustituidos para usarse en las enfermedades mediadas por la hormona concentradora de melanina 1.
WO2008071646A1 (en) 2006-12-11 2008-06-19 Boehringer Ingelheim International Gmbh New pyridazine derivatives with mch antagonistic activity and medicaments comprising these compounds
US7935697B2 (en) 2006-12-28 2011-05-03 Kinex Pharmaceuticals, Llc Compositions for modulating a kinase cascade and methods of use thereof
EP2114158B1 (en) * 2007-01-03 2012-08-08 Cortex Pharmaceuticals, Inc. 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses
DK2124562T3 (en) 2007-03-09 2016-08-01 Second Genome Inc BICYCLOHETEROARYLFORBINDELSER AS P2X7 modulators and uses thereof
TWI417100B (zh) 2007-06-07 2013-12-01 Astrazeneca Ab 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CN101412682B (zh) * 2007-10-19 2012-06-27 上海药明康德新药开发有限公司 芳基氨茴酸及其衍生物的合成方法
AU2009240643B2 (en) * 2008-04-23 2014-03-06 Rigel Pharmaceuticals, Inc. Carboxamide compounds for the treatment of metabolic disorders
SA109300358B1 (ar) 2008-06-06 2012-11-03 استرازينيكا ايه بي مقويات مستقبل جلوتامات ذي انتحاء أيضي من أيزو إندولون
US9079896B2 (en) 2008-08-02 2015-07-14 Janssen Pharmaceutica Nv Urotensin II receptor antagonists
AR075402A1 (es) 2009-02-13 2011-03-30 Sanofi Aventis Derivados heterociclicos oxigenados y/o nitrogenados de tetrahidronaftaleno, medicamentos que los contienen y uso de los mismos en el tratamiento de trastornos metabolicos, tales como obesidad,entre otros.
TW201040154A (en) 2009-02-13 2010-11-16 Sanofi Aventis Novel substituted indanes, process for preparation thereof and use thereof as a medicament
EP2558085B1 (en) 2010-04-16 2017-08-30 Athenex, Inc. Compositions and methods for the prevention and treatment of cancer
GB201009853D0 (en) 2010-06-11 2010-07-21 Chroma Therapeutics Ltd HSP90 inhibitors
BR112013028886A2 (pt) * 2011-05-10 2016-08-09 Gilead Sciences Inc compostos heterocíclicos fundidos como moduladores dde canal de sódio
NO3175985T3 (xx) 2011-07-01 2018-04-28
TW201837023A (zh) 2011-07-01 2018-10-16 美商基利科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
UY34194A (es) * 2011-07-15 2013-02-28 Astrazeneca Ab ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad?
US8933079B2 (en) * 2012-03-07 2015-01-13 Boehringer Ingelheim International Gmbh Pyridone and pyridazinone derivatives as anti-obesity agents
CN105263907B (zh) 2012-08-30 2018-11-20 阿西纳斯公司 作为蛋白质酪氨酸激酶调节剂的n-(3-氟苄基)-2-(5-(4-吗啉代苯基)吡啶-2-基)乙酰胺
FR3000491B1 (fr) * 2012-09-27 2015-08-28 Univ Lille Ii Droit & Sante Composes utilisables dans le traitement des infections mycobacteriennes
CN110407824B (zh) * 2019-08-08 2021-07-02 安徽医科大学 芳基甲酰胺类化合物及其制备方法、药物组合物及用途
CN114901652A (zh) * 2019-09-17 2022-08-12 比亚尔R&D投资股份公司 用于治疗医学病症的经取代的饱和和不饱和n-杂环甲酰胺及相关化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021577A2 (en) * 1999-09-20 2001-03-29 Takeda Chemical Industries, Ltd. Melanin concentrating hormone antagonist
AU2001256733A1 (en) * 2000-05-16 2001-11-26 Takeda Chemical Industries Ltd. Melanin-concentrating hormone antagonist
WO2002006245A1 (en) * 2000-07-05 2002-01-24 Synaptic Pharmarceutical Corporation Selective melanin concentrating hormone-1 (mch1) receptor antagonists and uses thereof
US20030022891A1 (en) * 2000-12-01 2003-01-30 Anandan Palani MCH antagonists and their use in the treatment of obesity
HK1054390B (en) * 2000-12-22 2006-01-06 Schering Corporation Piperidine mch antagonists and their use in the treatment of obesity
GB0124627D0 (en) * 2001-10-15 2001-12-05 Smithkline Beecham Plc Novel compounds
GB0124931D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds

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AR043046A1 (es) 2005-07-13
EA200500301A1 (ru) 2006-02-24
TW200413332A (en) 2004-08-01
EA012834B1 (ru) 2009-12-30
NO20050068L (no) 2005-03-04
CN1678591A (zh) 2005-10-05
WO2004024702A1 (de) 2004-03-25
EP1534689A1 (de) 2005-06-01
CA2496563A1 (en) 2004-03-25
RS20050173A (sr) 2007-09-21
MXPA05002158A (es) 2005-05-23
UA82853C2 (en) 2008-05-26
AU2003258620A1 (en) 2004-04-30

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