ZA200406015B - Dihydro-thia-phenanthrene-carbonyl-quanidines, me thod for the production thereof, use thereof as a medicament or diagnostic reagent. - Google Patents

Description

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DIHYDROTHIAPHENANTHRENECARBONYLGUANIDINES, PROCESS FOR THEIR “ PREPARATION, THEIR USE AS MEDICAMENT OR DIAGNOSTIC AID

Description

Dihydrothiaphenanthrenecarbonylguanidines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them

The invention relates to dihydrothiaphenanthrenecarbonylguanidines of the formula

R4 Rs

HN R3 A R6 »=N

H,N R7 0

R1 R2 R9 R8 in which the meanings are:

R(1) and R(3) : independently of one another hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, F, Cl, Br, I, CN, NR(10)R(11), -Op~(CH2)n-(CF2)x-CF3 or -(SOm)p-(CH2)n-(CF2)x-CF3;

R(10) and R(11) independently of one another hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or -(CH2)n-(CF2)x-CF3; m zero, 1 or 2; n zero, 1,2, 3,4,50r6; x and p independently of one another zero or 1;

R(2) hydrogen, F, Cl, Br, I, CN, alkyl having 1, 2, 3 or 4 carbon atoms, methoxy, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms,

R(4) and R(5) independently of one another hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms;

R(6), R(7), R(8) and R(9) independently of one another hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms; alkoxy having 1, 2, 3 or 4 carbon atoms, F, Cl, Br, |, CN, NR(12)R(13), -Oq-(CH2)~(CF2)g-CF3 or -(SOWt-(CH2)-(CF2)-CF3;

R(12) and R(13)

“ a . Co independently of one another hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms; w zero, 1 or 2; rand u zero, 1, 2, 3,4, 5 or 6; qg,s,tandv independently of one another zero or 1; or

R(6) and R(7) or R(7) and R(8) or R(8) and R(9) together with the phenyl ring carrying them a naphthalene system;

A -S-, -SO- or -SO9- and the pharmaceutically suitable salts thereof.

Preference is given to compounds of the formula | in which the meanings are:

R(1) and R(3) independently of one another hydrogen, methyl, ethyl, methoxy, ethoxy, F, Cl,

CN, NR(10)R(11), -Op~(CH2)n~CF 3 or -(SOm)p-(CH2)n-CF 3;

R(10) and R(11) independently of one another hydrogen, methyl, ethyl or -CH2-CF3; m zero, 1 or 2; n zero, 1,2 or 3; p independently of one another zero or 1;

R(2) hydrogen, F, Cl, CN, alkyl having 1, 2, 3 or 4 carbon atoms, methoxy, cycloalkyl having 3, 4, 5 or 6 carbon atoms,

R(4) and R(5) independently of one another hydrogen, methyl or ethyl;

R(6), R(7), R(8) and R(9) independently of one another hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms; methoxy, ethoxy, F, Cl, CN, NR(12)R(13), -Oq~(CH2)CF3 or -(SOwi-(CH2),-CF 3;

R(12) and R(13) independently of one another hydrogen, methyl or ethyl;

N }

Ww zero, 1 or 2; rand u zero, 1,2 or 3; gandt independently of one another zero or 1; or

R(6) and R(7) or R(7) and R(8) or R(8) and R(9) together with the phenyl ring carrying them a naphthalene system;

A -S-, -SO- or -SO2- and the pharmaceutically suitable salts thereof.

Particular preference is given to compounds of the formula 1, in which the meanings are:

R(1) hydrogen, methyl, ethyl, methoxy, ethoxy, F, Cl, NR(10)R(11), -Op~(CH2)n-CF3 or (SOm)p-(CH2)n-CF3;

R(10) and R(11) independently of one another hydrogen, methyl, ethyl or ~-CH2-CF3; m zero, 1 or 2; n, p independently of one another zero or 1;

R(2) hydrogen, F, Cl, methyl, cycloalkyl having 3, 4, 5 or 6 carbon atoms,

R(3), R(4) and R(5) hydrogen;

R(6), R(7), R(8) and R(9) independently of one another hydrogen, methyl; methoxy, ethoxy, F, Cl,

NR(12)R(13), -Og-(CH2)-CF3 or -(SOWi-(CH9),-CF3;

R(12) and R(13) independently of one another hydrogen, methyl or ethyl; w zero, 1 or 2; q,r.tand u independently of one another zero or 1; or

N

R(6) and R(7) or R(7) and R(8) or R(8) and R(9) together with the phenyl ring carrying them a naphthalene system;

A -S-, -SO- or -SO2- and the pharmaceutically suitable salts thereof.

Very particular preference is given to compounds of the formula | in which the meanings are:

R(1) hydrogen, methyl, methoxy, ethoxy, Cl, NR(10)R(11), -O-CH2-CF3 or -(8Om)p-(CH2)n-CF 3;

R(10) and R(11) independently of one another hydrogen, methyl, ethyl or -CH2-CF3; m zero, 1 or 2; p zero or 1;

R(2) hydrogen, F, Cl or methyl; : R(3), R(4) and R(5) hydrogen;

R(6), R(7), R(8) and R(9) independently of one another hydrogen, methyl; methoxy, ethoxy, F, CI, -O-

CH2-CF3 or -(SOw}k-(CH2),-CF3; w zero, 1 or 2; tandu independently of one another zero or 1; or

R(6) and R(7) or R(7) and R(8) or R(8) and R(9) together with the phenyl ring carrying them a naphthalene system;

A -SO9- and the pharmaceutically suitable salts thereof.

The compounds of the formula | may with appropriate substitution exist in stereoisomeric forms. If the compounds of the formula | contain one or more centers of

N asymmetry, these may have, independently of one another, the S configuration or the

R configuration. All possible stereoisomers, e.g. enantiomers or diastereomers, and mixtures of two or more stereoisomeric forms, e.g. enantiomers and/or diastereomers, in any ratios, belong to the invention. Thus, enantiomers for example belong to the 5 invention in enantiopure form, both as levorotatory and as dextrorotatory antipodes, and in the form of mixtures of the two enantiomers in various ratios or in the form of racemates. Individual stereoisomers can be prepared if desired by fractionation of a mixture by conventional methods or, for example, by stereoselective synthesis. If mobile hydrogen atoms are present, the present invention also encompasses all tautomeric forms of the compounds of the formula |.

The designated alkyl radicals may be straight-chain or branched. The invention further relates to a process for preparing the compound |, which comprises reacting a compound of the formula Il

R4 Rs

R3 A R6

L

O

Rt R2R9 R38 in which R(1) to R(9) and A have the stated meaning, and L is a leaving group amenable to easy nucleophilic substitution, with guanidine.

The activated acid derivatives of the formula Il in which L is an alkoxy, preferably a methoxy, group, a phenoxy group, phenyithio, methylthio, 2-pyridylthio group, a nitrogen heterocycle, preferably 1-imidazolyl, are advantageously obtained in a manner known per se from the underlying carbonyl chlorides (formula Ii, L = Ci), which in turn can be prepared in a manner known per se from the underlying carboxylic acids (formula 11, L = OH), for example with thionyl chloride.

Besides the carbonyl chlorides of the formula Il (L = Cl), it is also possible to prepare other activated acid derivatives of the formula Il in a manner known per se directly from

< - " = ) the underlying benzoic acid derivatives (formula li, L = OH), such as the methyl esters of the formula II with L = OCH3 by treatment with gaseous HCI in methanol, the imidazolides of the formula Il by treatment with carbonyldiimidazole [L = 1-imidazolyl,

Staab, Angew. Chem. Int. Ed. Engl. 1, 351 -367 (1962)], the mixed anhydrides I with

CI-COOC2Hj5 or tosyl chloride in the presence of triethylamine in an inert solvent, as well as activations of benzoic acids with dicyclohexylcarbodiimide (DCC) or with

O-[(cyano(ethoxycarbonyl)methylene)amino}-1,1,3,3-tetramethyluronium tetrafluoroborate (“TOTU”) [Proceedings of the 21st European Peptide Symposium, : Peptides 1990, Editors E. Giralt and D. Andreu, Escom, Leiden, 1991]. A number of suitable methods for preparing activated carboxylic acid derivatives of the formula are indicated in J. March, Advanced Organic Chemistry, 3rd Edition (John Wiley &

Sons, 1985), page 350, indicating the source literature.

Reaction of an activated carboxylic acid derivative of the formula Il with guanidine takes place in a manner known per se in a protic or aprotic polar but inert organic solvent. Those which have proved suitable in the reaction of the methyl benzoates (Il, L = OMe) with guanidinomethanol, isopropanol or THF from 20°C to the boiling point of these solvents. Most of the reactions of compounds Il with salt-free guanidine have advantageously been carried out in aprotic inert solvents such as THF, dimethoxyethane, dioxane. However, water can also be used as solvent in the reaction of Il with guanidine if a base such as, for example, NaOH is employed.

When L is Cl, it is advantageous to add an acid scavenger, e.g. in the form of excess guanidine to bind the hydrohalic acid.

Assembly of the dihydrothiaphenanthrenecarboxylic acid framework advantageously starts from appropriately substituted benzylsulfanyls, phenylmethanesulfinyls or phenylmethanesulfonyls. These are subjected to an intramolecular aryl-aryl coupling as known in principle (see Chem. Rev. 95 (7), 2457 (1995) or “Metal-catalyzed Cross- coupling Reactions®, Diederich, Francois; Stang, Peter J.; Editors Germany (1998)

Publisher: (Wiley-VCH, Weinheim, Germany), 517) or Tetrahedron (1998), 54(3/4), 263). Coupling of a boronic acid with a suitable aryl halide such as an aryl chloride, aryl bromide, ary! iodide or with a suitable aryl ester such as an aryl mesylate or aryl trifluoromethanesulfonate is preferred. In these cases, the boronic acid function may

N have been introduced both on the benzyl and on the benzoic acid reactant. It is also particularly preferred to use bis(pinakolato)diboron as described in Tetrahedron Lett. (1997), 38(22), 3841-3844. Formula Ill describes such a starting material in which R(1) to R(9) and A and L have the stated meaning, and X and Y are each a halogen or an -0-SO9CHg or an -O-SO2CF3. The preferred catalytic metal is palladium, particularly preferably in its complex Pd(dppf)o. The reaction is carried out in a dipolar aprotic solvent, preferably DMF or DMA, at a temperature between 0°C and the boiling point of the solvent, preferably at temperatures between 40°C and 120°C.

R7

R6 R8

R5

R4 RY R4 R5

R3 A Y R3 A R6

L L asec 0 0)

R1 R2 R1 R2 R9 R8 1] }

The derivatives of the general formula lll are preferably prepared from 3-mercapto- benzoic acid derivatives or from 3-sulfinobenzoic acid derivatives of the formula IV with activated benzyl derivatives of the formula V:

R7

R3 A—H R6 R8

L x + Rg — ; R4 R9

R1 RO y4 Y

AY) \")

In this case, Z is a leaving group amenable to easy nucleophilic substitution, such as, for example, chlorine, bromine, iodine, mesylate, tosylate or trifluoromethanesulfonate.

The derivatives IV and V are reacted in a suitable solvent such as DMF, THF or acetonitrile, using a base such as triethylamine or DIPEA, at a temperature between -20°C and the boiling point of the solvent, preferably at a temperature of between 0°C and 40°C.

Aroylguanidines | are generally weak bases and are able to bind acid to form salts.

Suitable acid addition salts are salts of all pharmacologically acceptable acids, for example halides, especially hydrochlorides, lactates, sulfates, citrates, tartrates, acetates, phosphates, methylsulfonates, p-toluenesulifonates.

The compounds | are substituted acylguanidines.

Compared with known compounds, the compounds of the invention are distinguished by exceptionally high activity in inhibition of Na*/H* exchange.

Just like the known compounds, they have no undesired and disadvantageous salurific properties but have very good antiarrhythmic properties as are important, for example 156 for the treatment of disorders occurring in association with manifestations of oxygen deficiency. As a consequence of their pharmacological properties, the compounds are outstandingly suitable as antiarrhythmic medicaments with a cardioprotective component for prophylaxis of infarction and treatment of infarction, and for the treatment of angina pectoris, and they also inhibit or greatly reduce in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, especially in the initiation of ischemia-induced cardiac arrhythmias. Because of their protective effects against pathological hypoxic and ischemic situations, the compounds of the invention, of the formula |, can be used, as a consequence of inhibition of the cellular Na*/H* exchange mechanism, as medicaments for the treatment of all acute or chronic damage induced by ischemia or disorders induced primarily or secondarily thereby. This relates to their use as medicaments for surgical operations, e.g. in organ transplants, where the compounds can be used both to protect the organs in the donor before and during removal, to protect removed organs for example during treatment with or storage thereof in physiological bath fluids, and on transferring to the recipient organism. The compounds are likewise valuable medicaments with a protective effect when angioplastic surgical operations are performed for example on the heart and on peripheral vessels. In

N accordance with their protective effect against ischemia-induced damage, the compounds are also suitable as medicaments for the treatment of ischemias of the nervous system, especially of the CNS, being suitable, for example, for the treatment of stroke or cerebral edema. In addition, the compounds of the invention, of the formula |, are likewise suitable for the treatment of types of shock such as, for example, of allergic, cardiogenic, hypovolemic and bacterial shock.

In addition, the compounds of the invention, of the formula I, are distinguished by a strong inhibitory effect on the proliferation of cells, for example fibroblast cell proliferation and the proliferation of smooth vascular muscle cells. The compounds of the formula | are therefore suitable as valuable therapeutic agents for disorders in which cell proliferation represents a primary or secondary cause, and can therefore be used as antiatherosclerotics, agents to prevent late complications of diabetes, cancers, fibrotic disorders such as pulmonary fibrosis, hepatic fibrosis or renal fibrosis, organ hypertrophies and hyperplasias, especially for prostate hyperplasia and prostate hypertrophy.

The compounds of the invention are effective inhibitors of the cellular sodium-proton antiporter (Na*/H* exchanger) which in numerous disorders (essential hypertension, atherosclerosis, diabetes etc.) is also increased in cells which are readily amenable to measurements, such as, for example, in erythrocytes, platelets or leukocytes. The compounds of the invention are therefore suitable as excellent and simple scientific tools, for example in their use as diagnostic aids for the determination and differentiation of particular forms of hypertension, but also of atherosclerosis, of diabetes, proliferative disorders etc. In addition, the compounds of the formula | are suitable for preventive therapy to prevent the development of high blood pressure, for example of essential hypertension.

It has additionally been found that compounds of the formula | show a beneficial effect on serum lipoproteins. It is generally acknowledged that blood lipid levels which are too high, so called hyperlipoproteinemias, represent a considerable risk factor for the development of arteriosclerotic vascular lesions, especially coronary heart disease.

The lowering of elevated serum lipoproteins therefore has exceptional importance for the prophylaxis and regression of atherosclerotic lesions. Besides a reduction in total serum cholesterol, it is particularly important to reduce the proportion of specific atherogenic lipid fractions of this total cholesterol, especially the low density lipoproteins (LDL) and the very low density lipoproteins (VLDL), because these lipid fractions represent an atherogenic risk factor. By contrast, a protective function against coronary heart disease is ascribed to the high density lipoproteins. Accordingly, hypolipidemics should be able to reduce not only total cholesterol but, in particular, the

VLDL and LDL serum cholesterol fractions. It has now been found that compounds of the formula | show valuable therapeutically utilizable properties in relation to the effect on the serum lipid levels. Thus, they significantly reduce the elevated serum LDL and

VLDL concentration which are to be observed for example due to increased dietary intake of a cholesterol- and lipid-rich diet or in association with pathological metabolic changes, for example, genetically related hyperlipidemias. They can therefore be used for the prophylaxis and regression of atherosclerotic lesions through the elimination of a causal risk factor. These include not only primary hyperlipidemias but also certain secondary hyperlipidemias as occur, for example, in association with diabetes. In addition, the compounds of the formula | lead to a marked reduction in the infarctions induced by metabolic abnormalities and, in particular, a significant reduction in the induced infarct size and its severity. Compounds of the formula | further lead to effective protection against endothelial damage induced by metabolic abnormalities.

This protection of vessels against the syndrome of endothelial dysfunction makes compounds of the formula | valuable medicaments for the prevention and treatment of coronary vasospasmes, of atherogenesis and of atherosclerosis, of left-ventricular hypertrophy and of dilated cardiomyopathy, and thrombotic disorders.

Said compounds are therefore advantageously used for producing a medicament for the treatment of hypercholesterolemia; for producing a medicament for the prevention of atherogenesis; for producing a medicament for the prevention and treatment of atherosclerosis, for producing a medicament for the prevention and treatment of disorders induced by elevated cholesterol levels, for producing a medicament for the prevention and treatment of disorders induced by endothelial dysfunction, for producing a medicament for the prevention and treatment of atherosclerosis-induced hypertension, for producing a medicament for the prevention and treatment of atherosclerosis-induced thromboses, for producing a medicament for the prevention

KY and treatment of hypercholesterolemia - induced and endothelial dysfunction - induced ischemic damage and postischemic reperfusion damage, for producing a medicament for the prevention and treatment of hypercholesterolemia - induced and endothelial dysfunction - induced cardiac hypertrophies. cardiomyopaties and congestive heart failure (CHF), for producing a medicament for the prevention and treatment of hypercholesterolemia - induced and endothelial dysfunction - induced coronary vasospasms and myocardial infarctions, for producing a medicament for the treatment of said disorders in combinations with hypotensive substances, preferably with angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor antagonists, a combination of an NHE inhibitor of the formula | with a hypolipidemic active ingredient, preferably with an HMG-CoA reductase inhibitor (e.g. lovastatin or pravastatin), the latter having a hypolipidemic effect and thus increasing the hypolipidemic properties of the NHE inhibitor of the formula | proves to be a favorable combination with enhanced effect and reduced active ingredient usage.

The administration of sodium/proton exchange inhibitors of the formula | as novel medicaments for reducing elevated blood lipid levels, and the combination of sodium/proton exchange inhibitors with hypotensive medicaments and/or medicaments having hypolipidemic activity are claimed.

Also claimed are the administration of sodium/proton exchange inhibitors of the formula I, and the combination of sodium/proton exchange inhibitors with hypotensive medicaments, especially with ACE inhibitors (for example ramipril) and with angiotensin receptor antagonists (for example losartan) as novel medicaments for the treatment of CHF.

Medicaments comprising a compound | can moreover be administered orally, parenterally, intravenously, rectally or by inhalation, with the preferred administration being dependent on the particular appearance of the disorder. The compounds | can moreover be used alone or together with pharmaceutical excipients, both in veterinary medicine and in human medicine.

Excipients suitable for the desired pharmaceutical formulation are familiar to the skilled worker on the basis of his expert knowledge. Besides solvents, gel formers, suppository bases, tablet excipients and other active ingredient carriers, it is possible to use, for example, antioxidants, dispersants, emulsifiers, antifoams, masking flavors, preservatives, solubilizers or colors.

For a form for oral use, the active compounds are mixed with the additives suitable for this purpose, such as carriers, stabilizers or inert diluents, and converted by convenional methods into suitable dosage forms such as tablets, coated tablets, two- piece capsules, aqueous, alcoholic or oily solutions. Examples of inert carriers which can be used are gum arabic, magnesia, magnesium carbonate, potassium phosphate, lactose, glucose or starch, especially corn starch. Preparation can moreover take place both as dry and as wet granules. Examples of suitable oily carriers or solvents are vegetable or animal oils such as sunflower oil or fish liver oil.

For subcutaneous or intravenous administration, the active compounds are converted into a solution, suspension or emulsion, if desired with the substances customary for this purpose, such as solubilizers, emulsifiers or other excipients. Examples of suitable solvents are: water, physiological saline or alcohol, e.g. ethanol, propanol, glycerol, either as sugar solutions such as glucos or mannitol solutions, or else a mixture of the various solvents mentioned.

Suitable as pharmaceutical formulation for administration in the form of aerosols or sprays are, for example, solutions, suspensions or emulsions of the active ingredient of the formula | in a pharmaceutically acceptable solvent such as, in particular, ethanol or water, or a mixture of such solvents. The formulation may if required also comprise other pharmaceutical excipients such as surfactants, emulsifiers and stabilizers, and a propellant gas. Such a preparation normally contains the active ingredient in a concentration of about 0.1 to 10, in particular of about 0.3 to 3 % by weight.

The dosage of the active ingredient of the formula | to be administered and the frequency of administration depend on the potency and duration of action of the compounds used; also on the nature and severity of the disorder to be treated, and on the sex, age, weight and individual response of the mammal to be treated.

On average, the daily dose of a compound of the formula | for a patient weighing about 75 kg is at least 0.001 mg/kg, preferably 0.01 mg/kg, up to a maximum of 10 mg/kg, preferably up to a maximum of 1 mg/kg, of bodyweight. For acute episodes of the disorder, for example immediately after suffering a myocardial infarction, it may be necessary for the dosages also to be higher and, in particular, more frequent, e.g. up to 4 single doses per day. Especially on i.v. use, for example for an infarct patient in an intensive care unit, up to 200 mg per day and kg of bodyweight may be necessary.

List of abbreviations:

DIPEA diisopropylethylamine

DMA N,N-dimethylacetamide

DME 1,2-dimethoxyethane

DMF N,N-dimethylformamide 16 EA ethyl acetate (EtOAc) eq. equivalent

MeOH methanol

Pd(dppf)2 [1,1’-bis(diphenyiphosphino)ferrocene]palladium(ll) chloride/- methylene chloride complex (1:1)

RT room temperature m.p. melting point

THF tetrahydrofuran

Experimental part

General method for the synthesis of dihydrothiaphenanthrenecarbonylguanidines

Stage 1) Methyl 4-bromo-5-chlorosulfonyl-2-methylbenzoate 12 g of 4-bromo-5-chlorosulfonyl-2-methylbenzoic acid (J.Med.Chem. 1997, 40, 2017) and 20 ml of thionyl chloride were boiled under reflux with exclusion of moisture for 8 hours. The excess thionyl chloride was removed in vacuo in a rotary evaporator, and the residue was taken up in about 50 mi of dry toluene and again evaporated. The crude acid chloride was dissolved in 25 ml of anhydrous toluene and, after addition of 1.7 ml of MeOH, stirred at 50°C for 2 h. A further 1.7 mi of MeOH were then added, followed by stirring at 50°C for 4 h. The reaction mixture was diluted with 200 ml of EA and washed with 100 ml of a saturated aqueous NaHCO3 solution. After drying over

NasSOy4, the solvents were removed in vacuo. 11.0 g of a pale yellow oil were obtained and were used without further purification.

Stage 2) 2-Bromo-5-methoxycarbonyl-4-methylbenzenesulfinic acid 550 mg of NapSO3 were dissolved in 2 ml of water and, at 70°C, a solution of 337 mg of methyl 4-bromo-5-chlorosulfonyl-2-methylbenzoate in 2 ml of DME was added dropwise. During the dropwise addition, the solution became weakly acidic (pH = 5).

The mixture was then stirred at 70°C for 2.5 h, allowed to cool and adjusted to pH = 1-2 with aqueous HCI solution. It was diluted with 50 ml of EA and washed with 50 ml of a saturated aqueous NaCl solution. After drying over NapSO4, the solvents were removed in vacuo. 228 mg of a pale yellow oil were obtained and were used without further purification.

Stage 3) Methyl 4-bromo-5-(2-bromophenylmethanesulfonyl)-2-methylbenzoate 150 mg (0.51 mmol) of 2-bromo-5-methoxycarbonyl-4-methylbenzenesulfinic acid (stage 2) were dissolved in 1.5 ml of DMF. To this were added 128 mg (0.51 mmol) of 2-bromobenzyl bromide dissolved in 0.5 ml of DMF, and 0.1 ml (0.56 mMol) of DIPEA, and the mixture was stirred at room temperature with exclusion of moisture for 16 hours. The reaction solution was filtered, diluted with 20 ml of EA and washed with 20 ml of 1N hydrochloric acid and then 20 ml of 5% strength brine. The organic phase was forced through a drying cartridge (anhydrous sodium sulfate), and the cartridge was washed with 5 ml of EA. The filtrate was evaporated. The crude product was purified by preparative HPLC.

Claims (17)

Patent claims

1. A dihydrothiaphenanthrenecarbonylguanidine of the formula R4 Rs HN R3 A R6 =N HN wae 0 R1 R2 R9 R8 in which the meanings are: R(1) and R(3) independently of one another hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, F, CI, Br, I, CN, NR(10)R(11), -Op-(CH2)n~(CF2)x-CF3 or ~(SOm)p-(CH2)n-(CF2)x-CF3; R(10) and R(11) independently of one another hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or -(CH2)-(CF2)y-CFa; m zero, 1 or 2; n zero, 1,2,3,4,50r6; x and p independently of one another zero or 1; R(2) hydrogen, F, Cl, Br, I, CN, alkyl having 1, 2, 3 or 4 carbon atoms, methoxy, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms, R(4)and R(5) independently of one another hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms; R(6), R(7), R(8) and R(9) independently of one another hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms; alkoxy having 1, 2, 3 or 4 carbon atoms, F, CI, Br, I, CN, NR(12)R(13), -Oq-(CH2)~(CF2)g-CF3 or -(SOW}-(CH2),-(CF2)-CF3; R(12) and R(13) independently of one another hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms;

w zero, 1 or 2; randu zero, 1, 2, 3,4, 5 or 6; q,s,tandv independently of one another zero or 1; or R(6) and R(7) or R(7) and R(8) or R(8) and R(9) together with the phenyl ring carrying them a naphthalene system; A -S-, -SO- or -SO2- and the pharmaceutically suitable salts thereof.

2. A compound of the formula | as claimed in claim 1, in which the meanings are: R(1) and R(3) independently of one another hydrogen, methyl, ethyl, methoxy, ethoxy, F, Cl, CN, NR(10)R(11), -Op-(CH2)n-CF3 or (SOm)p-(CH2)n-CF 3; R(10) and R(11) independently of one another hydrogen, methyl, ethyl or -CH2-CF3; m zero, 1 or 2; n zero, 1,2 or 3; p independently of one another zero or 1; R(2) hydrogen, F, Cl, CN, alkyl having 1, 2, 3 or 4 carbon atoms, methoxy, cycloalkyl having 3, 4, 5 or 6 carbon atoms, R(4) and R(5) independently of one another hydrogen, methyl or ethyl; R(6), R(7), R(8) and R(9) independently of one another hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms; methoxy, ethoxy, F, Cl, CN, NR(12)R(13), -Og(CH2)-CF3 or -(SOwt-(CH2)y-CF3; R(12) and R(13) independently of one another hydrogen, methyl or ethyl; w zero, 1 or 2; rand u zero, 1,2 or 3; gandt independently of one another zero or 1; or R(6) and R(7) or R(7) and R(8) or R(8) and R(9) together with the phenyl ring carrying them a naphthalene system; A -S-, -SO- or -SO2- and the pharmaceutically suitable salts thereof.

3. A compound of the formula | as claimed in claims 1 or 2, in which the meanings are: R(1) hydrogen, methyl, ethyl, methoxy, ethoxy, F, Cl, NR(10)R(11), -Op-(CH2)n-CF3 or (SOm)p-(CH2)n-CF3; R(10) and R(11) independently of one another hydrogen, methyl, ethyl or -CH2-CF3; m zero, 1 or 2; n,p independently of one another zero or 1; R(2) hydrogen, F, Cl, methyl, cycloalkyl having 3, 4, 5 or 6 carbon atoms, R(3), R(4) and R(5) hydrogen; R(6), R(7), R(8) and R(9) independently of one another hydrogen, methyl; methoxy, ethoxy, F, Cl, NR(12)R(13), -Og-(CH2)-CF3 or -(SOw)t-(CH2),-CF 3; R(12) and R(13) independently of one another hydrogen, methyl or ethyl; w zero, 1 or 2; q,r,tandu independently of one another zero or 1; or R(6)and R(7) or R(7) and R(8) or R(8) and R(9) together with the phenyl ring carrying them a naphthalene system; A -S-, -S0O- or -S09-

and the pharmaceutically suitable salts thereof.

4. A compound of the formula | as claimed in claims 1 to 3, in which the meanings are: R(1) hydrogen, methyl, methoxy, ethoxy, Cl, NR(10)R(11), -O-CH2-CF3 or ~(SOm)p-(CH2)n-CF3; R(10) and R(11) independently of one another hydrogen, methyl, ethyl or -CH2-CF3; m zero, 1 or 2; p zero or 1; R(2) hydrogen, F, Cl or methyl; : R(3), R(4) and R(5) hydrogen; R(6), R(7), R(8) and R(9) independently of one another hydrogen, methyl; methoxy, ethoxy, F, Cl, -O- CH2-CF3 or -(SOw)t-(CH2),-CF 3; w zero, 1 or 2; tand u independently of one another zero or 1; or R(6) and R(7) or R(7) and R(8) or R(8) and R(9) together with the phenyl ring carrying them a naphthalene system; A -SO2- and the pharmaceutically suitable salts thereof.

5. The use of a compound | as claimed in claim 1 for producing a medicament for the treatment or prophylaxis of disorders caused by ischemic states.

6. A method for the treatment and prophylaxis of disorders caused by ischemic states, which comprises an effective amount of a compound | as claimed in claim 1 being mixed with conventional additives and administered in a suitable dosage form.

7. The use of a compound | as claimed in claim 1 for producing a medicament for the treatment or prophylaxis of myocardial infarction and of arrhythmias.

8. The use of a compound | as claimed in claim 1 for producing a medicament for the treatment or prophylaxis of angina pectoris.

9. The use of a compound | as claimed in claim 1 for producing a medicament for the treatment or prophylaxis of ischemic states of the heart.

10. The use of a compound | as claimed in claim 1 for producing a medicament for the treatment or prophylaxis of ischemic states of the peripheral and central nervous system and of stroke.

11. The use of a compound | as claimed in claim 1 for producing a medicament for the treatment or prophylaxis of ischemic states of peripheral organs and limbs.

12. The use of a compound | as claimed in claim 1 for producing a medicament for the treatment of states of shock.

13. The use of a compound | as claimed in claim 1 for producing a medicament for use during surgical operations and organ transplantations.

14, The use of a compound | as claimed in claim 1 for producing a medicament for the preservation and storage of transplants for surgical procedures.

15. The use of a compound | as claimed in claim 1 for producing a medicament for the treatment of disorders in which cell proliferation represents a primary or secondary cause.

16. The use of a compound | as claimed in claim 1 for producing a medicament for the treatment or prophylaxis of disorders of lipid metabolism.

17. A medicament comprising an effective amount of a compound | as claimed in one or more of claims 1 to 4.