ZA200309977B - Arylamines for the treatment of conditions associated with GSK-3. - Google Patents
Arylamines for the treatment of conditions associated with GSK-3.Info
- Publication number
- ZA200309977B ZA200309977B ZA200309977A ZA200309977A ZA200309977B ZA 200309977 B ZA200309977 B ZA 200309977B ZA 200309977 A ZA200309977 A ZA 200309977A ZA 200309977 A ZA200309977 A ZA 200309977A ZA 200309977 B ZA200309977 B ZA 200309977B
- Authority
- ZA
- South Africa
- Prior art keywords
- arylamines
- gsk
- treatment
- conditions associated
- conditions
- Prior art date
Links
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 title 1
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 title 1
- 150000004982 aromatic amines Chemical class 0.000 title 1
Classifications
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0102439A SE0102439D0 (sv) | 2001-07-05 | 2001-07-05 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200309977B true ZA200309977B (en) | 2005-03-23 |
Family
ID=20284777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200309977A ZA200309977B (en) | 2001-07-05 | 2003-12-23 | Arylamines for the treatment of conditions associated with GSK-3. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20060052396A1 (xx) |
| EP (1) | EP1414801A1 (xx) |
| JP (1) | JP2005505515A (xx) |
| KR (1) | KR20040013102A (xx) |
| CN (1) | CN1551869A (xx) |
| AR (1) | AR036132A1 (xx) |
| BR (1) | BR0210838A (xx) |
| CA (1) | CA2452686A1 (xx) |
| CO (1) | CO5540341A2 (xx) |
| HU (1) | HUP0500339A2 (xx) |
| IL (1) | IL159347A0 (xx) |
| IS (1) | IS7095A (xx) |
| MX (1) | MXPA03011972A (xx) |
| NO (1) | NO20040014L (xx) |
| PL (1) | PL367782A1 (xx) |
| RU (1) | RU2004102389A (xx) |
| SE (1) | SE0102439D0 (xx) |
| WO (1) | WO2003004472A1 (xx) |
| ZA (1) | ZA200309977B (xx) |
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| ATE325115T1 (de) | 2002-08-19 | 2006-06-15 | Glaxo Group Ltd | Pyrimidinderivate als selektive cox-2-inhibitoren |
| GB0221443D0 (en) | 2002-09-16 | 2002-10-23 | Glaxo Group Ltd | Pyridine derivates |
| SE0203754D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| SE0203752D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| MXPA05009245A (es) | 2003-03-11 | 2005-10-19 | Pfizer Prod Inc | Nuevos compuestos de pirazina como inhibidores del factor de crecimiento transformante (tgf). |
| JP4058368B2 (ja) * | 2003-03-27 | 2008-03-05 | ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー | 超音波診断装置 |
| JP2007531757A (ja) * | 2004-03-30 | 2007-11-08 | カイロン コーポレイション | 抗癌剤としての置換チオフェン誘導体 |
| CA2577937C (en) * | 2004-08-26 | 2010-12-21 | Pfizer Inc. | Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors |
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| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| WO2006117212A2 (en) | 2005-05-04 | 2006-11-09 | Develogen Aktiengesellschaft | Use of gsk-3 inhibitors for preventing and treating pancreatic autoimmune disorders |
| EP1749523A1 (en) | 2005-07-29 | 2007-02-07 | Neuropharma, S.A. | GSK-3 inhibitors |
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| TW200730512A (en) * | 2005-12-12 | 2007-08-16 | Astrazeneca Ab | Novel compounds |
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| BR112012012156A2 (pt) | 2009-11-06 | 2015-09-08 | Plexxikon Inc | compostos e métodos para modulação de cinase, e indicações para esta |
| WO2011089416A1 (en) | 2010-01-19 | 2011-07-28 | Astrazeneca Ab | Pyrazine derivatives |
| WO2011143423A2 (en) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2011143422A1 (en) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | 2 -aminopyridine derivatives useful as inhibitors of atr kinase |
| MX2012013081A (es) * | 2010-05-12 | 2013-05-09 | Vertex Pharma | Compuestos utiles como inhibidores de cinasa atr. |
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| US8623869B2 (en) | 2010-06-23 | 2014-01-07 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2621914B1 (en) | 2010-09-27 | 2016-12-28 | Abbott GmbH & Co. KG | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
| US9090592B2 (en) | 2010-12-30 | 2015-07-28 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
| AU2012214762B2 (en) | 2011-02-07 | 2015-08-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| CN102718745A (zh) * | 2011-03-30 | 2012-10-10 | 中国科学院上海药物研究所 | 新型胺基吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途 |
| MX2013011450A (es) | 2011-04-05 | 2014-02-03 | Vertex Pharma | Compuestos de aminopirazina utiles como inhibidores de la cinasa ataxia telangiectasia mutada y rad3 relacionados (atr). |
| PL2714677T3 (pl) * | 2011-05-23 | 2019-02-28 | Merck Patent Gmbh | Pochodne pirydynowe i pirazynowe |
| WO2012178123A1 (en) | 2011-06-22 | 2012-12-27 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US9096602B2 (en) | 2011-06-22 | 2015-08-04 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-B]pyrazines as ATR kinase inhibitors |
| JP2014517079A (ja) | 2011-06-22 | 2014-07-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atrキナーゼ阻害剤として有用な化合物 |
| RS59337B1 (sr) | 2011-09-30 | 2019-10-31 | Vertex Pharma | Postupak za izradu jedinjenja, korisnih kao inhibitori atr kinaze |
| SG11201401095YA (en) | 2011-09-30 | 2014-04-28 | Vertex Pharma | Treating pancreatic cancer and non-small cell lung cancer with atr inhibitors |
| EP2751088B1 (en) | 2011-09-30 | 2016-04-13 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2751099B1 (en) | 2011-09-30 | 2017-06-14 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2013049720A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US8841450B2 (en) | 2011-11-09 | 2014-09-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2776419B1 (en) | 2011-11-09 | 2016-05-11 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
| EP2776429A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2013071090A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US8846917B2 (en) | 2011-11-09 | 2014-09-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| ES2654670T3 (es) | 2012-04-05 | 2018-02-14 | Vertex Pharmaceuticals Incorporated | Compuestos útiles como inhibidores de la cinasa ATR y terapias de combinación de los mismos |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| WO2014055756A1 (en) | 2012-10-04 | 2014-04-10 | Vertex Pharmaceuticals Incorporated | Method for measuring atr inhibition mediated increases in dna damage |
| EP2909202A1 (en) | 2012-10-16 | 2015-08-26 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| PT4190786T (pt) | 2012-12-07 | 2025-05-29 | Vertex Pharma | Compostos úteis como inibidores da quinase atr |
| EP2970286A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase |
| CA2932757C (en) | 2013-12-06 | 2023-10-31 | Vertex Pharmaceuticals Incorporated | 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof |
| KR102575125B1 (ko) | 2014-06-05 | 2023-09-07 | 버텍스 파마슈티칼스 인코포레이티드 | Atr 키나제의 저해제로서 유용한 2-아미노-6-플루오로-n-[5-플루오로-피리딘-3-일]-피라졸로[1,5-a]피리미딘-3-카복스아미드 화합물의 방사성표지된 유도체, 상기 화합물의 제조 및 이의 다양한 고체 형태 |
| RU2736219C2 (ru) | 2014-06-17 | 2020-11-12 | Вертекс Фармасьютикалз Инкорпорейтед | Способ лечения рака с использованием комбинации ингибиторов снк1 и atr |
| EP3741375A1 (en) | 2014-07-17 | 2020-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating neuromuscular junction-related diseases |
| JO3589B1 (ar) * | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| AU2016331955B2 (en) | 2015-09-30 | 2022-07-21 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors |
| GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
| CN108697811B (zh) | 2016-01-11 | 2023-04-07 | 梅里麦克制药股份有限公司 | 抑制共济失调毛细血管扩张和Rad3相关蛋白(ATR) |
| WO2017216342A1 (en) | 2016-06-16 | 2017-12-21 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method for preparing induced hepatic progenitor cells |
| DK3971177T3 (da) | 2016-07-20 | 2024-07-15 | Novartis Ag | Aminopyridin-derivater og anvendelse deraf som selektive ALK-2-inhibitorer |
| TW201811766A (zh) | 2016-08-29 | 2018-04-01 | 瑞士商諾華公司 | N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途 |
| JP2022520671A (ja) | 2019-02-08 | 2022-03-31 | フリークエンシー・セラピューティクス・インコーポレイテッド | 耳障害を治療するためのバルプロ酸化合物及びwnt作動薬 |
| CN115038443A (zh) | 2019-11-22 | 2022-09-09 | 因西特公司 | 包含alk2抑制剂和jak2抑制剂的组合疗法 |
| WO2021257532A1 (en) | 2020-06-16 | 2021-12-23 | Incyte Corporation | Alk2 inhibitors for the treatment of anemia |
| WO2022031946A1 (en) | 2020-08-06 | 2022-02-10 | Chdi Foundation, Inc. | Heterobiaryl compounds and imaging agents for imaging huntingtin protein |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5547004A (en) * | 1992-01-28 | 1996-08-20 | Klockner Hansel Tevopharm B.V. | Method and device for arranging a stream of products |
| MA26473A1 (fr) * | 1997-03-01 | 2004-12-20 | Glaxo Group Ltd | Composes pharmacologiquement actifs. |
| NZ520484A (en) * | 2000-02-16 | 2005-03-24 | Neurogen Corp | Substituted arylpyrazines that are modulators of CRF (corticotropin releasing factor) receptor and methods of treatment using them |
| AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
-
2001
- 2001-07-05 SE SE0102439A patent/SE0102439D0/xx unknown
-
2002
- 2002-07-03 PL PL02367782A patent/PL367782A1/xx not_active Application Discontinuation
- 2002-07-03 RU RU2004102389/04A patent/RU2004102389A/ru not_active Application Discontinuation
- 2002-07-03 CA CA002452686A patent/CA2452686A1/en not_active Abandoned
- 2002-07-03 CN CNA028135458A patent/CN1551869A/zh active Pending
- 2002-07-03 EP EP02747795A patent/EP1414801A1/en not_active Withdrawn
- 2002-07-03 KR KR10-2004-7000080A patent/KR20040013102A/ko not_active Withdrawn
- 2002-07-03 HU HU0500339A patent/HUP0500339A2/hu unknown
- 2002-07-03 JP JP2003510640A patent/JP2005505515A/ja active Pending
- 2002-07-03 US US10/481,721 patent/US20060052396A1/en not_active Abandoned
- 2002-07-03 WO PCT/SE2002/001339 patent/WO2003004472A1/en not_active Ceased
- 2002-07-03 MX MXPA03011972A patent/MXPA03011972A/es unknown
- 2002-07-03 IL IL15934702A patent/IL159347A0/xx unknown
- 2002-07-03 BR BR0210838-0A patent/BR0210838A/pt not_active Application Discontinuation
- 2002-07-05 AR ARP020102533A patent/AR036132A1/es unknown
-
2003
- 2003-12-23 ZA ZA200309977A patent/ZA200309977B/xx unknown
- 2003-12-30 CO CO03113306A patent/CO5540341A2/es not_active Application Discontinuation
- 2003-12-31 IS IS7095A patent/IS7095A/is unknown
-
2004
- 2004-01-02 NO NO20040014A patent/NO20040014L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040013102A (ko) | 2004-02-11 |
| SE0102439D0 (sv) | 2001-07-05 |
| MXPA03011972A (es) | 2004-03-26 |
| CN1551869A (zh) | 2004-12-01 |
| BR0210838A (pt) | 2004-07-13 |
| EP1414801A1 (en) | 2004-05-06 |
| WO2003004472A8 (en) | 2003-03-13 |
| US20060052396A1 (en) | 2006-03-09 |
| JP2005505515A (ja) | 2005-02-24 |
| PL367782A1 (en) | 2005-03-07 |
| NO20040014L (no) | 2004-03-02 |
| CA2452686A1 (en) | 2003-01-16 |
| AR036132A1 (es) | 2004-08-11 |
| WO2003004472A1 (en) | 2003-01-16 |
| HUP0500339A2 (hu) | 2005-07-28 |
| IS7095A (is) | 2003-12-31 |
| RU2004102389A (ru) | 2005-07-10 |
| CO5540341A2 (es) | 2005-07-29 |
| IL159347A0 (en) | 2004-06-01 |
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