ZA200205694B - Treatment of diabetic ulcers. - Google Patents
Treatment of diabetic ulcers.Info
- Publication number
- ZA200205694B ZA200205694B ZA200205694A ZA200205694A ZA200205694B ZA 200205694 B ZA200205694 B ZA 200205694B ZA 200205694 A ZA200205694 A ZA 200205694A ZA 200205694 A ZA200205694 A ZA 200205694A ZA 200205694 B ZA200205694 B ZA 200205694B
- Authority
- ZA
- South Africa
- Prior art keywords
- treatment
- diabetic ulcers
- ulcers
- diabetic
- inhibitors
- Prior art date
Links
- 206010056340 Diabetic ulcer Diseases 0.000 title abstract 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 2
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 abstract 2
- 208000008960 Diabetic foot Diseases 0.000 abstract 1
- 101100189582 Dictyostelium discoideum pdeD gene Proteins 0.000 abstract 1
- 101150098694 PDE5A gene Proteins 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 102100029175 cGMP-specific 3',5'-cyclic phosphodiesterase Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- ZOOGRGPOEVQQDX-UHFFFAOYSA-N cyclic GMP Natural products O1C2COP(O)(=O)OC2C(O)C1N1C=NC2=C1NC(N)=NC2=O ZOOGRGPOEVQQDX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229960003310 sildenafil Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0000561.1A GB0000561D0 (en) | 2000-01-11 | 2000-01-11 | Treatment of diabetic ulcers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200205694B true ZA200205694B (en) | 2003-08-11 |
Family
ID=9883498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200205694A ZA200205694B (en) | 2000-01-11 | 2002-07-10 | Treatment of diabetic ulcers. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20030176442A1 (xx) |
| EP (1) | EP1248623B1 (xx) |
| JP (1) | JP2003519652A (xx) |
| KR (1) | KR20020082841A (xx) |
| AT (1) | ATE285775T1 (xx) |
| AU (1) | AU2540301A (xx) |
| CA (1) | CA2396120A1 (xx) |
| DE (1) | DE60108068T2 (xx) |
| ES (1) | ES2233599T3 (xx) |
| GB (1) | GB0000561D0 (xx) |
| HU (1) | HUP0204097A2 (xx) |
| IL (1) | IL150395A0 (xx) |
| NZ (1) | NZ519722A (xx) |
| WO (1) | WO2001051042A2 (xx) |
| ZA (1) | ZA200205694B (xx) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0020588D0 (en) * | 2000-08-21 | 2000-10-11 | Pfizer Ltd | Treatment of wounds |
| US20020065286A1 (en) * | 2000-08-21 | 2002-05-30 | Davies Michael John | Treatment of wounds |
| GB0129274D0 (en) * | 2001-12-06 | 2002-01-23 | Pfizer Ltd | Novel kit |
| US8133903B2 (en) | 2003-10-21 | 2012-03-13 | Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center | Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases |
| WO2004082667A1 (en) * | 2003-03-17 | 2004-09-30 | Pfizer Products Inc. | Treatment of type 1 diabetes with pde5 inhibitors |
| DE102005001989A1 (de) * | 2005-01-15 | 2006-07-20 | Bayer Healthcare Ag | Intravenöse Formulierungen von PDE-Inhibitoren |
| US20090163504A1 (en) * | 2006-10-27 | 2009-06-25 | Kopacki Matthew H | Method for healing a wound using a phosphodiesterase type five inhibitor |
| US10143694B2 (en) | 2006-10-27 | 2018-12-04 | Matthew H. Kopacki | Advanced formulations and therapies for treating hard-to-heal wounds |
| KR101377178B1 (ko) | 2010-04-05 | 2014-03-26 | 에스케이케미칼주식회사 | Ｐｄｅ5 억제제를 함유하는 피부 주름 개선용 조성물 |
| AT512084A1 (de) | 2011-10-20 | 2013-05-15 | Univ Wien Tech | Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren |
| MX2017016930A (es) * | 2017-12-19 | 2019-06-20 | Malesil Research & Tech Llc | Uso del maleato de sildenafil en el tratamiento de ulceras de pie diabetico. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6166219A (en) * | 1995-12-28 | 2000-12-26 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| US5958926A (en) * | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| US6043252A (en) * | 1997-05-05 | 2000-03-28 | Icos Corporation | Carboline derivatives |
| US6037346A (en) * | 1997-10-28 | 2000-03-14 | Vivus, Inc. | Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| HUP0102543A3 (en) * | 1998-04-20 | 2002-01-28 | Pfizer | Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction and medicaments containing them |
| US6200591B1 (en) * | 1998-06-25 | 2001-03-13 | Anwar A. Hussain | Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction |
| IT1312310B1 (it) * | 1999-05-07 | 2002-04-15 | Recordati Ind Chimica E Farma | Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale |
| US6075028A (en) * | 1999-09-23 | 2000-06-13 | Graham; Richard | Method of treating Tourette's syndrome and related CNS disorders |
| TWI265925B (en) * | 1999-10-11 | 2006-11-11 | Pfizer | Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them |
| US6271228B1 (en) * | 2000-04-28 | 2001-08-07 | Pfizer Inc. | Blood pressure stabilization during hemodialysis |
| US20030105108A1 (en) * | 2002-12-19 | 2003-06-05 | Wood Ralph E. | Method of treating peripheral vascular diseases, peripheral neuropathies, and autonomic neuropathies |
| US20020065286A1 (en) * | 2000-08-21 | 2002-05-30 | Davies Michael John | Treatment of wounds |
-
2000
- 2000-01-11 GB GBGB0000561.1A patent/GB0000561D0/en not_active Ceased
-
2001
- 2001-01-11 DE DE60108068T patent/DE60108068T2/de not_active Expired - Fee Related
- 2001-01-11 AT AT01900568T patent/ATE285775T1/de not_active IP Right Cessation
- 2001-01-11 EP EP01900568A patent/EP1248623B1/en not_active Expired - Lifetime
- 2001-01-11 IL IL15039501A patent/IL150395A0/xx unknown
- 2001-01-11 US US10/169,921 patent/US20030176442A1/en not_active Abandoned
- 2001-01-11 AU AU25403/01A patent/AU2540301A/en not_active Abandoned
- 2001-01-11 HU HU0204097A patent/HUP0204097A2/hu unknown
- 2001-01-11 ES ES01900568T patent/ES2233599T3/es not_active Expired - Lifetime
- 2001-01-11 WO PCT/IB2001/000018 patent/WO2001051042A2/en not_active Ceased
- 2001-01-11 KR KR1020027009000A patent/KR20020082841A/ko not_active Ceased
- 2001-01-11 NZ NZ519722A patent/NZ519722A/xx unknown
- 2001-01-11 CA CA002396120A patent/CA2396120A1/en not_active Abandoned
- 2001-01-11 JP JP2001551466A patent/JP2003519652A/ja active Pending
-
2002
- 2002-07-10 ZA ZA200205694A patent/ZA200205694B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0204097A2 (hu) | 2003-04-28 |
| NZ519722A (en) | 2004-12-24 |
| GB0000561D0 (en) | 2000-03-01 |
| CA2396120A1 (en) | 2001-07-19 |
| AU2540301A (en) | 2001-07-24 |
| JP2003519652A (ja) | 2003-06-24 |
| US20030176442A1 (en) | 2003-09-18 |
| DE60108068D1 (de) | 2005-02-03 |
| IL150395A0 (en) | 2002-12-01 |
| EP1248623A2 (en) | 2002-10-16 |
| KR20020082841A (ko) | 2002-10-31 |
| EP1248623B1 (en) | 2004-12-29 |
| WO2001051042A2 (en) | 2001-07-19 |
| ATE285775T1 (de) | 2005-01-15 |
| DE60108068T2 (de) | 2005-12-08 |
| WO2001051042A3 (en) | 2002-01-10 |
| ES2233599T3 (es) | 2005-06-16 |
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