ZA200109859B - 6-Alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations. - Google Patents

6-Alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations.

Info

Publication number: ZA200109859B
Authority: ZA; South Africa
Prior art keywords: alkinyl; alkenyl; epoxy; production; pharmaceutical preparations
Prior art date: 1999-04-30

Application number

ZA200109859A

Other languages

English (en)

Inventor

Ulrich Klar

Werner Skuballa

Jens Hoffmann

Wolfgang Schwede

Bernd Buchmann

Rosemarie Lichtner

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-30

Filing date

2001-11-29

Publication date

2003-02-28

1999-04-30 Priority claimed from DE19921086A external-priority patent/DE19921086A1/de

1999-11-04 Priority claimed from DE19954228A external-priority patent/DE19954228A1/de

2000-03-27 Priority claimed from DE10015836A external-priority patent/DE10015836A1/de

2001-11-29 Application filed by Schering Ag filed Critical Schering Ag

2003-02-28 Publication of ZA200109859B publication Critical patent/ZA200109859B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Hematology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA200109859A 1999-04-30 2001-11-29 6-Alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations. ZA200109859B (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE19921086A DE19921086A1 (de)	1999-04-30	1999-04-30	6-Alkenyl- und 6-Alkinyl-Epothilon Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
DE19954228A DE19954228A1 (de)	1999-11-04	1999-11-04	6-Alkenyl-und 6-Alkinyl-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
DE10015836A DE10015836A1 (de)	2000-03-27	2000-03-27	6-Alkenyl- und 6-Alkinyl-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
PCT/IB2000/000657 WO2000066589A1 (fr)	1999-04-30	2000-05-01	Derives 6-alcenyl-, 6-alkinyl-, et 6-epoxy-epothilone, procede de preparation et leur utilisation dans des preparations pharmaceutiques

Publications (1)

Publication Number	Publication Date
ZA200109859B true ZA200109859B (en)	2003-02-28

Family

ID=27213767

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200109859A ZA200109859B (en)	1999-04-30	2001-11-29	6-Alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations.

Country Status (33)

Country	Link
EP (1)	EP1173441B1 (fr)
JP (2)	JP4024003B2 (fr)
KR (1)	KR100721488B1 (fr)
CN (1)	CN100368415C (fr)
AR (1)	AR023792A1 (fr)
AT (1)	ATE440847T1 (fr)
BG (1)	BG65601B1 (fr)
BR (1)	BR0010190A (fr)
CA (2)	CA2371226C (fr)
CY (1)	CY1109768T1 (fr)
CZ (1)	CZ299653B6 (fr)
DE (1)	DE60042821D1 (fr)
DK (1)	DK1173441T3 (fr)
EA (1)	EA011502B1 (fr)
EE (1)	EE05292B1 (fr)
ES (1)	ES2331506T3 (fr)
HK (1)	HK1046681B (fr)
HR (1)	HRP20010892A2 (fr)
HU (1)	HUP0201010A3 (fr)
IL (1)	IL145938A0 (fr)
ME (1)	MEP13908A (fr)
MX (1)	MXPA01011039A (fr)
NO (1)	NO328149B1 (fr)
NZ (1)	NZ514989A (fr)
PE (1)	PE20010116A1 (fr)
PL (1)	PL210762B1 (fr)
PT (1)	PT1173441E (fr)
RS (1)	RS51023B (fr)
SI (1)	SI1173441T1 (fr)
SK (1)	SK286858B6 (fr)
TW (2)	TWI280962B (fr)
WO (1)	WO2000066589A1 (fr)
ZA (1)	ZA200109859B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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EP1186606B2 (fr)	1995-11-17	2011-09-07	Gesellschaft für Biotechnologische Forschung mbH (GBF)	Derivés d'épothilone, leur procédé de production et utilisation
ES2312695T3 (es)	1996-11-18	2009-03-01	Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf)	Epotilones e y f.
US6204388B1 (en)	1996-12-03	2001-03-20	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
JP4579351B2 (ja)	1996-12-03	2010-11-10	スローン−ケッタリングインスティトュートフォアキャンサーリサーチ	エポチロンの合成とその中間体及びその類似物並びにその使用
US6605599B1 (en)	1997-07-08	2003-08-12	Bristol-Myers Squibb Company	Epothilone derivatives
US6365749B1 (en)	1997-12-04	2002-04-02	Bristol-Myers Squibb Company	Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6380395B1 (en)	1998-04-21	2002-04-30	Bristol-Myers Squibb Company	12, 13-cyclopropane epothilone derivatives
US6498257B1 (en)	1998-04-21	2002-12-24	Bristol-Myers Squibb Company	2,3-olefinic epothilone derivatives
US6518421B1 (en)	2000-03-20	2003-02-11	Bristol-Myers Squibb Company	Process for the preparation of epothilone analogs
US6593115B2 (en)	2000-03-24	2003-07-15	Bristol-Myers Squibb Co.	Preparation of epothilone intermediates
DE10020899A1 (de) *	2000-04-20	2001-10-25	Schering Ag	9-Oxa-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
UA75365C2 (en) *	2000-08-16	2006-04-17	Bristol Myers Squibb Co	Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon
MXPA03006485A (es)	2001-01-25	2003-09-22	Bristol Myers Squibb Co	Formulacion parenteral que contiene analogos de epotilona.
EP1938821B1 (fr)	2001-01-25	2016-03-30	Bristol-Myers Squibb Company	Formulation d'un analogue de l'epothilone destinée au traitement du cancer
WO2002058699A1 (fr) *	2001-01-25	2002-08-01	Bristol-Myers Squibb Company	Formes pharmaceutiques d'epothilones pour administration orale
EE200300397A (et)	2001-02-20	2003-12-15	Bristol-Myers Squibb Company	Epotilooni derivaadid refraktaarsete kasvajate raviks
WO2002066038A1 (fr)	2001-02-20	2002-08-29	Bristol-Myers Squibb Company	Traitement de tumeurs refractaires a l'aide de derives d'epothilone
ES2384789T3 (es)	2001-03-14	2012-07-12	Bristol-Myers Squibb Company	Combinación de un análogo de epotilona y agentes quimioterapéuticos para el tratamiento de enfermedades proliferativas
CA2449077A1 (fr)	2001-06-01	2002-12-12	Gregory D. Vite	Derives d'epothilone
EP1340498A1 (fr) *	2002-03-01	2003-09-03	Schering Aktiengesellschaft	Utilisation d'épothilones dans le traitement de maladies du cerveau associées aux processus de prolifération
AU2003218110A1 (en)	2002-03-12	2003-09-29	Bristol-Myers Squibb Company	C3-cyano epothilone derivatives
US7211593B2 (en)	2002-03-12	2007-05-01	Bristol-Myers Squibb Co.	C12-cyano epothilone derivatives
TW200403994A (en)	2002-04-04	2004-03-16	Bristol Myers Squibb Co	Oral administration of EPOTHILONES
TW200400191A (en)	2002-05-15	2004-01-01	Bristol Myers Squibb Co	Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives
WO2003105828A1 (fr)	2002-06-14	2003-12-24	Bristol-Myers Squibb Company	Combinaison d'analogues d'epothilone et agents chimiotherapeutiques utiles dans le traitement des maladies proliferatives
CA2499600C (fr)	2002-09-23	2012-08-21	Daniel Benigni	Procedes de preparation, d'isolation et de purification d'epothilone b, et structures cristallines x d'epothilone b
DE10361794B3 (de) *	2003-12-31	2005-10-06	Schering Ag	Optisch aktive heteroaromatische ß-Hydroxy-Ester und Verfahren zu deren Herstellung sowie deren Verwendung als Zwischenprodukte bei der Epothilon-Totalsynthese
EP1559447A1 (fr)	2004-01-30	2005-08-03	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Utilisation d'epothilone pour le traitement de defauts de connectivité neuronale comme par exemple la schizophrenie et l'autisme
EP1640004A1 (fr) *	2004-09-24	2006-03-29	Schering Aktiengesellschaft	Utilisation des epothilones pour le traitement des metastases osseuses ou du cancer des os
US20060121511A1 (en)	2004-11-30	2006-06-08	Hyerim Lee	Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
EP1674098A1 (fr) *	2004-12-23	2006-06-28	Schering Aktiengesellschaft	Formulations parenterales stables et tolérables des substances de haut réactivité ayant une solubilité basse ou inexistante dans l'eau
CN100384419C (zh) *	2005-12-02	2008-04-30	菏泽睿鹰制药集团有限公司	一种埃坡霉素缓释植入组合物及应用
DE102007016046A1 (de)	2007-03-30	2008-10-23	Bayer Schering Pharma Aktiengesellschaft	Verfahren zur Herstellung von Epothilonderivaten durch selektive katalytische Epoxidierung
EP2065054A1 (fr)	2007-11-29	2009-06-03	Bayer Schering Pharma Aktiengesellschaft	Combinaisons comprenant une prostaglandine et leurs utilisations
DE102007059752A1 (de)	2007-12-10	2009-06-18	Bayer Schering Pharma Aktiengesellschaft	Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone
EP2070521A1 (fr)	2007-12-10	2009-06-17	Bayer Schering Pharma Aktiengesellschaft	Nanoparticules à surface modifiée
EP2210584A1 (fr)	2009-01-27	2010-07-28	Bayer Schering Pharma Aktiengesellschaft	Composition polymère stable comprenant un copolymère séquencé d'épothilone et amphiphile
US20110300150A1 (en)	2010-05-18	2011-12-08	Scott Eliasof	Compositions and methods for treatment of autoimmune and other disease
US9764038B2 (en)	2011-12-23	2017-09-19	Innate Pharma	Enzymatic conjugation of antibodies
EP2872894B1 (fr)	2012-07-13	2019-04-17	Innate Pharma	Criblage d'anticorps conjugués
EP3564259A3 (fr)	2012-11-09	2020-02-12	Innate Pharma	Étiquettes de reconnaissance pour la conjugaison à médiation par la tgase
US10611824B2 (en)	2013-03-15	2020-04-07	Innate Pharma	Solid phase TGase-mediated conjugation of antibodies
WO2014202773A1 (fr)	2013-06-20	2014-12-24	Innate Pharma	Conjugaison enzymatique de polypeptides
WO2014202775A1 (fr)	2013-06-21	2014-12-24	Innate Pharma	Conjugaison enzymatique de polypeptides
WO2019092148A1 (fr)	2017-11-10	2019-05-16	Innate Pharma	Anticorps avec des résidus de glutamine fonctionnalisés

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JPS54115320A (en) *	1978-02-28	1979-09-07	Soda Aromatic	Novel unsaturated keto acid and its manufacture
JP2653663B2 (ja) *	1988-02-15	1997-09-17	財団法人微生物化学研究会	１．３―ジヒドロキシ―８―デセン―５―オンを含む免疫賦活剤及び制癌剤
EP0469480A3 (en) *	1990-08-01	1993-03-10	Hoechst Aktiengesellschaft	Process for stereoselective preparation of 5-substituted delta-lactones and their use
CA2281105A1 (fr) *	1997-02-25	1998-09-03	Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf)	Epothilones a chaine laterale modifiee
DK1005465T3 (da) *	1997-08-09	2007-11-05	Bayer Schering Pharma Ag	Nye epothilon-derivater, fremgangsmåde til fremstilling heraf og deres farmaceutiske anvendelse

2000
- 2000-04-28 AR ARP000102024A patent/AR023792A1/es active IP Right Grant
- 2000-04-28 PE PE2000000403A patent/PE20010116A1/es not_active Application Discontinuation
- 2000-05-01 CA CA2371226A patent/CA2371226C/fr not_active Expired - Fee Related
- 2000-05-01 DE DE60042821T patent/DE60042821D1/de not_active Expired - Lifetime
- 2000-05-01 EE EEP200100568A patent/EE05292B1/xx not_active IP Right Cessation
- 2000-05-01 CZ CZ20013885A patent/CZ299653B6/cs not_active IP Right Cessation
- 2000-05-01 NZ NZ514989A patent/NZ514989A/xx not_active IP Right Cessation
- 2000-05-01 SI SI200031044T patent/SI1173441T1/sl unknown
- 2000-05-01 EP EP00922826A patent/EP1173441B1/fr not_active Expired - Lifetime
- 2000-05-01 ME MEP-139/08A patent/MEP13908A/xx unknown
- 2000-05-01 ES ES00922826T patent/ES2331506T3/es not_active Expired - Lifetime
- 2000-05-01 IL IL14593800A patent/IL145938A0/xx unknown
- 2000-05-01 CN CNB008069786A patent/CN100368415C/zh not_active Expired - Fee Related
- 2000-05-01 KR KR1020017013840A patent/KR100721488B1/ko not_active Expired - Fee Related
- 2000-05-01 WO PCT/IB2000/000657 patent/WO2000066589A1/fr active IP Right Grant
- 2000-05-01 AT AT00922826T patent/ATE440847T1/de active
- 2000-05-01 CA CA2651653A patent/CA2651653C/fr not_active Expired - Fee Related
- 2000-05-01 HU HU0201010A patent/HUP0201010A3/hu unknown
- 2000-05-01 PT PT00922826T patent/PT1173441E/pt unknown
- 2000-05-01 DK DK00922826T patent/DK1173441T3/da active
- 2000-05-01 PL PL351491A patent/PL210762B1/pl not_active IP Right Cessation
- 2000-05-01 RS YUP-776/01A patent/RS51023B/sr unknown
- 2000-05-01 MX MXPA01011039A patent/MXPA01011039A/es active IP Right Grant
- 2000-05-01 HR HR20010892A patent/HRP20010892A2/xx not_active Application Discontinuation
- 2000-05-01 SK SK1551-2001A patent/SK286858B6/sk not_active IP Right Cessation
- 2000-05-01 EA EA200101025A patent/EA011502B1/ru not_active IP Right Cessation
- 2000-05-01 HK HK02108204.3A patent/HK1046681B/zh not_active IP Right Cessation
- 2000-05-01 BR BR0010190-7A patent/BR0010190A/pt not_active IP Right Cessation
- 2000-05-01 JP JP2000615619A patent/JP4024003B2/ja not_active Expired - Fee Related
- 2000-05-18 TW TW89108133A patent/TWI280962B/zh not_active IP Right Cessation
- 2000-05-18 TW TW095145399A patent/TWI294292B/zh not_active IP Right Cessation
2001
- 2001-10-26 BG BG106053A patent/BG65601B1/bg unknown
- 2001-10-29 NO NO20015278A patent/NO328149B1/no not_active IP Right Cessation
- 2001-11-29 ZA ZA200109859A patent/ZA200109859B/xx unknown
2007
- 2007-04-11 JP JP2007104224A patent/JP4886578B2/ja not_active Expired - Fee Related
2009
- 2009-11-25 CY CY20091101237T patent/CY1109768T1/el unknown

Also Published As

Publication number	Publication date
CA2651653C (fr)	2012-02-14
EA200101025A1 (ru)	2002-06-27
EE200100568A (et)	2003-02-17
EE05292B1 (et)	2010-04-15
RS51023B (sr)	2010-10-31
JP2007224038A (ja)	2007-09-06
JP4024003B2 (ja)	2007-12-19
CY1109768T1 (el)	2014-09-10
HUP0201010A2 (en)	2002-08-28
WO2000066589A1 (fr)	2000-11-09
YU77601A (sh)	2005-07-19
CA2371226C (fr)	2011-11-29
EP1173441B1 (fr)	2009-08-26
HUP0201010A3 (en)	2005-02-28
TWI294292B (en)	2008-03-11
PT1173441E (pt)	2009-11-06
CN1349534A (zh)	2002-05-15
NO20015278D0 (no)	2001-10-29
JP2002543203A (ja)	2002-12-17
AR023792A1 (es)	2002-09-04
MXPA01011039A (es)	2003-06-30
PL351491A1 (en)	2003-04-22
BG106053A (en)	2002-05-31
TWI280962B (en)	2007-05-11
IL145938A0 (en)	2002-07-25
CZ20013885A3 (cs)	2002-04-17
KR100721488B1 (ko)	2007-05-23
HK1046681B (zh)	2008-08-29
EA011502B1 (ru)	2009-04-28
CA2651653A1 (fr)	2000-11-09
MEP13908A (en)	2010-06-10
CZ299653B6 (cs)	2008-10-08
HRP20010892A2 (hr)	2008-06-30
NO328149B1 (no)	2009-12-21
DE60042821D1 (de)	2009-10-08
DK1173441T3 (da)	2009-12-07
HK1046681A1 (zh)	2003-01-24
SK15512001A3 (sk)	2002-05-09
EP1173441A1 (fr)	2002-01-23
NO20015278L (no)	2001-12-21
BG65601B1 (bg)	2009-02-27
ATE440847T1 (de)	2009-09-15
CN100368415C (zh)	2008-02-13
NZ514989A (en)	2004-02-27
PE20010116A1 (es)	2001-02-15
CA2371226A1 (fr)	2000-11-09
BR0010190A (pt)	2002-01-08
KR20020005737A (ko)	2002-01-17
TW200711679A (en)	2007-04-01
SK286858B6 (sk)	2009-06-05
PL210762B1 (pl)	2012-02-29
JP4886578B2 (ja)	2012-02-29
SI1173441T1 (sl)	2010-01-29
ES2331506T3 (es)	2010-01-07

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