ZA200007770B - Novel 2,3,3A,4,9,9A hexahydro-8-hydroxy-1h-benz[f]indoles, a method for the production thereof, and their use as medicaments. - Google Patents
Novel 2,3,3A,4,9,9A hexahydro-8-hydroxy-1h-benz[f]indoles, a method for the production thereof, and their use as medicaments. Download PDFInfo
- Publication number
- ZA200007770B ZA200007770B ZA200007770A ZA200007770A ZA200007770B ZA 200007770 B ZA200007770 B ZA 200007770B ZA 200007770 A ZA200007770 A ZA 200007770A ZA 200007770 A ZA200007770 A ZA 200007770A ZA 200007770 B ZA200007770 B ZA 200007770B
- Authority
- ZA
- South Africa
- Prior art keywords
- general formula
- denote
- methyl
- nitrogen
- denote hydrogen
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 16
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 239000003814 drug Substances 0.000 title claims description 5
- QGPODKIUJLHCDK-UHFFFAOYSA-N 2,3,3a,4,4a,5-hexahydro-1H-benzo[f]indol-8-ol Chemical class OC=1C=CCC2CC3CCNC3=CC21 QGPODKIUJLHCDK-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 24
- 239000001257 hydrogen Substances 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 150000002431 hydrogen Chemical class 0.000 claims description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
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- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 10
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- ZVQOOHYFBIDMTQ-UHFFFAOYSA-N [methyl(oxido){1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-lambda(6)-sulfanylidene]cyanamide Chemical compound N#CN=S(C)(=O)C(C)C1=CC=C(C(F)(F)F)N=C1 ZVQOOHYFBIDMTQ-UHFFFAOYSA-N 0.000 claims 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19834714A DE19834714A1 (de) | 1998-07-31 | 1998-07-31 | Neue 2,3,3a,4,9,9a-Hexahydro-8-hydroxy-1H-ben[f]indole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200007770B true ZA200007770B (en) | 2002-01-17 |
Family
ID=7876092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200007770A ZA200007770B (en) | 1998-07-31 | 2000-12-21 | Novel 2,3,3A,4,9,9A hexahydro-8-hydroxy-1h-benz[f]indoles, a method for the production thereof, and their use as medicaments. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6051583A (fr) |
| EP (1) | EP1100780B1 (fr) |
| JP (1) | JP2002522418A (fr) |
| KR (1) | KR20010072142A (fr) |
| CN (1) | CN1147470C (fr) |
| AT (1) | ATE360611T1 (fr) |
| AU (1) | AU763834B2 (fr) |
| BG (1) | BG105178A (fr) |
| BR (1) | BR9912605A (fr) |
| CA (1) | CA2336783C (fr) |
| CO (1) | CO5080748A1 (fr) |
| DE (2) | DE19834714A1 (fr) |
| EA (1) | EA003370B1 (fr) |
| EE (1) | EE200100062A (fr) |
| ES (1) | ES2285851T3 (fr) |
| HU (1) | HUP0103518A3 (fr) |
| ID (1) | ID28292A (fr) |
| IL (1) | IL140863A0 (fr) |
| MY (1) | MY133085A (fr) |
| NO (1) | NO20010513L (fr) |
| NZ (1) | NZ510246A (fr) |
| PL (1) | PL345808A1 (fr) |
| SK (1) | SK1502001A3 (fr) |
| TR (1) | TR200100316T2 (fr) |
| TW (1) | TW464643B (fr) |
| UA (1) | UA68388C2 (fr) |
| WO (1) | WO2000007986A1 (fr) |
| YU (1) | YU5501A (fr) |
| ZA (1) | ZA200007770B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0002666D0 (en) | 2000-02-04 | 2000-03-29 | Univ London | Blockade of voltage dependent sodium channels |
| WO2003057219A1 (fr) * | 2001-12-27 | 2003-07-17 | Ortho-Mcneil Pharmaceutical Inc. | Arylpyrrole heteroaryle et methanols utilises pour le traitement de troubles du systeme nerveux central |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0151699B1 (ko) * | 1989-07-13 | 1998-10-15 | 로버트 에이. 아미테이지 | (1,2n) 및 (3,2n)-카보사이클릭-2-아미노테트랄린 유도체 |
| AU2153592A (en) * | 1991-05-20 | 1993-01-08 | Upjohn Company, The | Carboxamido-(3,2n)-carbocyclic-2-aminotetralin derivatives |
| GB9612153D0 (en) * | 1996-06-11 | 1996-08-14 | Smithkline Beecham Plc | Compounds |
-
1998
- 1998-07-31 DE DE19834714A patent/DE19834714A1/de not_active Ceased
-
1999
- 1999-07-22 ES ES99936584T patent/ES2285851T3/es not_active Expired - Lifetime
- 1999-07-22 CA CA002336783A patent/CA2336783C/fr not_active Expired - Fee Related
- 1999-07-22 JP JP2000563620A patent/JP2002522418A/ja active Pending
- 1999-07-22 KR KR1020017001334A patent/KR20010072142A/ko not_active Ceased
- 1999-07-22 AU AU51626/99A patent/AU763834B2/en not_active Ceased
- 1999-07-22 UA UA2001021382A patent/UA68388C2/uk unknown
- 1999-07-22 ID IDW20010244A patent/ID28292A/id unknown
- 1999-07-22 CN CNB998089702A patent/CN1147470C/zh not_active Expired - Fee Related
- 1999-07-22 BR BR9912605-2A patent/BR9912605A/pt not_active IP Right Cessation
- 1999-07-22 YU YU5501A patent/YU5501A/sh unknown
- 1999-07-22 TR TR2001/00316T patent/TR200100316T2/xx unknown
- 1999-07-22 EP EP99936584A patent/EP1100780B1/fr not_active Expired - Lifetime
- 1999-07-22 NZ NZ510246A patent/NZ510246A/en unknown
- 1999-07-22 WO PCT/EP1999/005222 patent/WO2000007986A1/fr not_active Ceased
- 1999-07-22 EE EEP200100062A patent/EE200100062A/xx unknown
- 1999-07-22 AT AT99936584T patent/ATE360611T1/de not_active IP Right Cessation
- 1999-07-22 SK SK150-2001A patent/SK1502001A3/sk unknown
- 1999-07-22 IL IL14086399A patent/IL140863A0/xx unknown
- 1999-07-22 EA EA200100107A patent/EA003370B1/ru not_active IP Right Cessation
- 1999-07-22 DE DE59914314T patent/DE59914314D1/de not_active Expired - Fee Related
- 1999-07-22 PL PL99345808A patent/PL345808A1/xx not_active Application Discontinuation
- 1999-07-22 HU HU0103518A patent/HUP0103518A3/hu unknown
- 1999-07-29 MY MYPI99003229A patent/MY133085A/en unknown
- 1999-07-29 TW TW088112896A patent/TW464643B/zh not_active IP Right Cessation
- 1999-07-30 CO CO99048374A patent/CO5080748A1/es unknown
- 1999-07-30 US US09/365,064 patent/US6051583A/en not_active Expired - Lifetime
-
2000
- 2000-12-21 ZA ZA200007770A patent/ZA200007770B/en unknown
-
2001
- 2001-01-24 BG BG105178A patent/BG105178A/xx unknown
- 2001-01-30 NO NO20010513A patent/NO20010513L/no not_active Application Discontinuation
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