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YU69691A - Postupak za pripremu stranih proteina u streptomicetama - Google Patents

Postupak za pripremu stranih proteina u streptomicetama

Info

Publication number
YU69691A
YU69691A YU69691A YU69691A YU69691A YU 69691 A YU69691 A YU 69691A YU 69691 A YU69691 A YU 69691A YU 69691 A YU69691 A YU 69691A YU 69691 A YU69691 A YU 69691A
Authority
YU
Yugoslavia
Prior art keywords
preparation
foreign proteins
streptomicetes
procedure
streptomycetes
Prior art date
Application number
YU69691A
Other languages
English (en)
Other versions
YU48435B (sh
Inventor
K.P. Koller
G. Riess
Original Assignee
Hoechst Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag. filed Critical Hoechst Ag.
Priority to HRP-696/91A priority Critical patent/HRP940770A2/hr
Publication of YU69691A publication Critical patent/YU69691A/sh
Publication of YU48435B publication Critical patent/YU48435B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

predloženi pronalazak se odnosi na postupak za pripremu stranih proteina u streptomicetama. Genske strukture koje se kodiraju prema signalnoj sekvenci kao i približno prvih deset amino kiselina tendamistata a takodje i od željenog proteina, dolazi do izražaja u ćelijama - domaćinima, strep-tomicetama sa velikim iskorišćenjem, pri čemu izlučuju fuzijske proteine u postojeću sredinu.
YU69691A 1990-04-21 1991-04-18 Postupak za dobijanje stranih proteina u streptomicetama YU48435B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HRP-696/91A HRP940770A2 (en) 1990-04-21 1994-10-25 Process for the production of stranger protein in streptomycetes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4012818A DE4012818A1 (de) 1990-04-21 1990-04-21 Verfahren zur herstellung von fremdproteinen in streptomyceten

Publications (2)

Publication Number Publication Date
YU69691A true YU69691A (sh) 1995-12-04
YU48435B YU48435B (sh) 1998-07-10

Family

ID=6404857

Family Applications (1)

Application Number Title Priority Date Filing Date
YU69691A YU48435B (sh) 1990-04-21 1991-04-18 Postupak za dobijanje stranih proteina u streptomicetama

Country Status (29)

Country Link
EP (1) EP0453969B1 (sh)
JP (1) JP3319605B2 (sh)
KR (1) KR0168669B1 (sh)
CN (1) CN1049248C (sh)
AT (1) ATE142263T1 (sh)
AU (1) AU630287B2 (sh)
BR (1) BR9101587A (sh)
CA (1) CA2040810C (sh)
CZ (1) CZ285440B6 (sh)
DE (2) DE4012818A1 (sh)
DK (1) DK0453969T3 (sh)
ES (1) ES2093043T3 (sh)
FI (1) FI911882L (sh)
GR (1) GR3021040T3 (sh)
HR (1) HRP940770A2 (sh)
HU (1) HU210358B (sh)
IE (1) IE911322A1 (sh)
IL (1) IL97903A0 (sh)
LT (1) LT3686B (sh)
LV (1) LV10494B (sh)
NO (1) NO911557L (sh)
NZ (1) NZ237882A (sh)
PL (2) PL169596B1 (sh)
PT (1) PT97427B (sh)
RU (1) RU2055892C1 (sh)
SK (1) SK110191A3 (sh)
TW (1) TW213487B (sh)
YU (1) YU48435B (sh)
ZA (1) ZA912937B (sh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI103805B1 (fi) * 1990-09-05 1999-09-30 Hoechst Ag Menetelmä preproinsuliinien hydroloimiseksi
DK0600372T3 (da) 1992-12-02 1997-08-11 Hoechst Ag Fremgangsmåde til fremstilling af proinsulin med korrekt forbundne cystinbroer.
ATE203998T1 (de) * 1993-04-27 2001-08-15 Hoechst Ag Amorphe monosphärische formen von insulinderivaten
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
CN1061375C (zh) * 1996-07-19 2001-01-31 中国科学院上海生物工程研究中心 利用异源启动子在链霉菌中表达透明颤菌血红蛋白
DK0821006T3 (da) 1996-07-26 2004-08-16 Aventis Pharma Gmbh Insulinderivater med öget zinkbinding
RU2122581C1 (ru) * 1997-11-27 1998-11-27 Закрытое акционерное общество "Фосфосорб" Штамм escherichia coli xli-blue/pinsr - продуцент препроинсулина
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
RU2162102C1 (ru) * 1999-09-08 2001-01-20 Головков Алексей Леонардович Рекомбинантная плазмида, кодирующая гибридный белок с проинсулином человека (варианты)
US7795384B2 (en) 2003-06-03 2010-09-14 Shanghai Centre Of Research & Development Of New Drugs Fusion protein suitable for high efficiency expression and the production method thereof
RU2395296C1 (ru) * 2009-02-19 2010-07-27 Общество С Ограниченной Ответственностью "Концерн О3" Способ получения препарата проинсулина для перорального применения
CN104818291A (zh) * 2015-05-08 2015-08-05 江南大学 一种链霉菌重组表达载体的构建及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366246A (en) 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
DE3418274A1 (de) 1984-05-17 1985-11-21 Hoechst Ag, 6230 Frankfurt Signalpeptid fuer die exkretion von peptiden in streptomyceten
DE3707150A1 (de) * 1987-03-06 1988-09-15 Hoechst Ag Tendamistat-derivate
DE3714866A1 (de) * 1987-05-05 1988-11-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3715033A1 (de) 1987-05-06 1988-11-17 Hoechst Ag Verfahren zur isolierung von fusionsproteinen
DE3716722A1 (de) 1987-05-19 1988-12-01 Hoechst Ag Gentechnologisches verfahren zur herstellung von angiogeninen
DE3843713A1 (de) * 1988-04-25 1989-11-02 Henkel Kgaa Verwendung von calcinierten hydrotalciten als katalysatoren fuer die ethoxylierung bzw. propoxylierung
DE58909556D1 (de) * 1988-11-03 1996-02-15 Hoechst Ag Verfahren zur Herstellung eines Insulin-Vorprodukts in Streptomyceten

Also Published As

Publication number Publication date
HRP940770A2 (en) 1997-06-30
JPH04228086A (ja) 1992-08-18
HU210358B (en) 1995-04-28
PT97427A (pt) 1992-01-31
PL289953A1 (en) 1991-11-04
CZ110191A3 (en) 1993-08-11
EP0453969A1 (de) 1991-10-30
AU630287B2 (en) 1992-10-22
PT97427B (pt) 1998-08-31
CA2040810C (en) 2001-07-24
FI911882A7 (fi) 1991-10-22
HU911302D0 (en) 1991-10-28
JP3319605B2 (ja) 2002-09-03
KR910018551A (ko) 1991-11-30
ES2093043T3 (es) 1996-12-16
LV10494B (en) 1996-02-20
RU2055892C1 (ru) 1996-03-10
EP0453969B1 (de) 1996-09-04
NO911557L (no) 1991-10-22
AU7515491A (en) 1991-10-24
KR0168669B1 (ko) 1999-01-15
YU48435B (sh) 1998-07-10
FI911882A0 (fi) 1991-04-18
HUT57268A (en) 1991-11-28
DK0453969T3 (sh) 1997-02-10
LV10494A (lv) 1995-02-20
GR3021040T3 (en) 1996-12-31
CN1049248C (zh) 2000-02-09
PL169596B1 (pl) 1996-08-30
ZA912937B (en) 1991-12-24
CA2040810A1 (en) 1991-10-22
FI911882L (fi) 1991-10-22
LTIP1523A (en) 1995-06-26
ATE142263T1 (de) 1996-09-15
IL97903A0 (en) 1992-06-21
DE59108128D1 (de) 1996-10-10
CZ285440B6 (cs) 1999-08-11
TW213487B (sh) 1993-09-21
IE911322A1 (en) 1991-10-23
BR9101587A (pt) 1991-12-10
CN1055952A (zh) 1991-11-06
PL169178B1 (pl) 1996-06-28
SK110191A3 (en) 1995-07-11
LT3686B (en) 1996-01-25
NZ237882A (en) 1993-12-23
NO911557D0 (no) 1991-04-19
DE4012818A1 (de) 1991-10-24

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