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YU48854B - Derivati n-(4-piperidinil) (dihidrobenzofuran ili dihidro-2h-benzopiran)karboksamida i postupak za njihovo dobijanje - Google Patents

Derivati n-(4-piperidinil) (dihidrobenzofuran ili dihidro-2h-benzopiran)karboksamida i postupak za njihovo dobijanje

Info

Publication number
YU48854B
YU48854B YU39691A YU39691A YU48854B YU 48854 B YU48854 B YU 48854B YU 39691 A YU39691 A YU 39691A YU 39691 A YU39691 A YU 39691A YU 48854 B YU48854 B YU 48854B
Authority
YU
Yugoslavia
Prior art keywords
aryl
6alkyl
hydrogen
alkyl
het
Prior art date
Application number
YU39691A
Other languages
English (en)
Other versions
YU39691A (sh
Inventor
Georges Henri Paul Van Daele
Jean-Paul René Marie Andre Bosmans
Michel Anna Jozef De Cleyn
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Priority to SI9110396A priority Critical patent/SI9110396B/sl
Priority to HR930483A priority patent/HRP930483B1/xx
Publication of YU39691A publication Critical patent/YU39691A/sh
Publication of YU48854B publication Critical patent/YU48854B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Pyrane Compounds (AREA)

Abstract

Jedinjenje formule njegov N-oksidni oblik, njegova so ili njegov stereohemijski izomerni oblik, u kojem: A je radikal formule -CH2- CH2- (a-1), - CH2- CH2- CH2- (a-2), ili - CH2-CH2-CH2-CH2- (a-3), u kojem jedan ili dva atoma vodonika u nevedenim radikalima (a-1) do (a-3) mogu biti zamenjeni sa C1-6alkil radikalom; R1 je vodonik ili halo; R2 je vodonik, amino, mono ili di(C1-6alkil)amino ili C1-6alkilkarbonilamino; R3 je vodonik ili C1-6alkil; L je C3-6cikloalkil, C5-6cikloalkanon, C3-6alkenil, u datom primeru supstituisan sa arilom, ili L je radikal formule -Alk-R4- (b-1), -Alk-X-R5- (b-2), -Alk-Y-C(=O)-R7 (b-3), ili -Alk-Y-C(=O)-NR9R10 (b-4), u kojoj svaki Alk je C1-6alkandiil; i R4 je vodonik, cijano, C1-6alkilsulfonilamino, C3-6cikloalkil, C5-6cikloalkanon, aril, di(aril)metil ili Het; R5 je vodonik, C1-6alkil, hidroksiC1-6alkil, C1-6cikloalkil, aril ili Het; X je O, S, SO2 ili NR6; navedeni R6 je vodonik, C1-6alkil ili aril; R7 je vodonik, C1-6alkil, C3-6cikloalkil, aril, arilC1-6alkil, di(aril)metil, C1-6alkiloksi ili hidroksi;Y je NR8 ili direktna veza; navedeni R8 je vodonik, C1-6alkil ili aril;R9 i R10 su svaki nezavisno vodonik, C1-6alkil, C3-6cikloalkil, aril ili arilC1-6alkil, ili R9 i R10 povezani sa atomom azota koji nosi R9 ili R10, mogu da obrazuju pirolidinil ili piperidinil prsten, pri cemu su oba u datom primeru supstituisana sa C1-6alkilom, aminom ili mono ili di(C1-6alkil)-aminom, ili navedeni R9 i R10 povezani sa azotom, koji nosi R9 i R10, mogu da obrazuju piperazinil ili 4-morfolinil radikal, pri cemu su oba u datom primeru supstituisana sa C1-6alkilom;svaki aril je nesupstituisani fenil ili fenil supstituisan sa 1, 2 ili 3 supstituenta, svaki nezavisno odabran iz grupe koju cine halo, hidroksi, C1-6alkil, C1-6alkoksi, aminosulfonil, C1-6alkilkarbonil, nitro, trifluorometil, amino ili aminokarbonil; a svaki Het je peto- ili sestoclani heterociklicni prsten, koji sadrzi 1, 2, 3 ili 4 hetero atoma odabrana izmedu kiseonika, sumpora ili azota, pod uslovom da nisu prisutna vise od 2 atoma kiseonika i/ili sumpora, pri cemu je navedeni peto- ili sestoclani prsten u datom primeru kondenzovan sa peto- ili sestoclanim, karboksilnim ili heterociklicnim prstenom, koji takode sdarzi 1, 2, 3 ili 4 hetero atoma odabrana izmedu kiseonika, sumpora i azota, pod uslovom, da ovaj poslednji prsten ne sadrzi vise od 2 atoma kiseonika i/ili sumpora i da je ukupan broj hetero atoma u sistemu biciklicnog prstena manji od 6; kada je Het moniociklican prstenasti sistem, u datom primeru moze biti supstituisan sa do 4 supstituenta; kada Het jeste biciklican prstenasti sistem, on moze u datom primeru biti supstituisan sa do 6 supstituenata; navedeni supstituenti su odabrani iz grupe koju cine halo, hidroksi, cijano, trifluorometil, C1-6alkil, aril C1-6alkil, aril, C1-6alkiloksi, C1-6alkiloksi C1-6alkil, hidroksi C1-6alkil, C1-6alkiltio, merkapto, nitro, amino mono i di(C1-6alkil)amino, aril C1-6alkilamino, aminokarbonil, mono i di(C1-6alkil)aminokarbo
YU39691A 1990-03-06 1991-03-06 Derivati n-(4-piperidinil) (dihidrobenzofuran ili dihidro-2h-benzopiran)karboksamida i postupak za njihovo dobijanje YU48854B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9110396A SI9110396B (sl) 1990-03-06 1991-03-06 Derivati N-(4-piperidinil)(dihidrobenzofuran ali dihidro-2H-benzopiran) karboksamida
HR930483A HRP930483B1 (en) 1990-03-06 1993-03-23 N-(4-piperidinyl) (dihydrobenzofuran or dihydro-2h-benzopyran)carboxamide derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909005014A GB9005014D0 (en) 1990-03-06 1990-03-06 N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives

Publications (2)

Publication Number Publication Date
YU39691A YU39691A (sh) 1994-06-10
YU48854B true YU48854B (sh) 2002-06-19

Family

ID=10672103

Family Applications (1)

Application Number Title Priority Date Filing Date
YU39691A YU48854B (sh) 1990-03-06 1991-03-06 Derivati n-(4-piperidinil) (dihidrobenzofuran ili dihidro-2h-benzopiran)karboksamida i postupak za njihovo dobijanje

Country Status (38)

Country Link
US (2) US5185335A (sh)
EP (1) EP0445862B1 (sh)
JP (1) JP2601566B2 (sh)
KR (1) KR0177521B1 (sh)
CN (1) CN1038936C (sh)
AT (1) ATE191912T1 (sh)
AU (1) AU636012B2 (sh)
BG (1) BG60381B1 (sh)
CA (1) CA2037575C (sh)
CY (1) CY2235B1 (sh)
CZ (1) CZ286617B6 (sh)
DE (1) DE69132119T2 (sh)
DK (1) DK0445862T3 (sh)
ES (1) ES2147175T3 (sh)
FI (1) FI101622B1 (sh)
GB (1) GB9005014D0 (sh)
GR (1) GR3033461T3 (sh)
HR (1) HRP930483B1 (sh)
HU (2) HU221627B1 (sh)
IE (1) IE910710A1 (sh)
IL (1) IL97018A (sh)
LT (1) LT3708B (sh)
LV (1) LV10085B (sh)
MA (1) MA22076A1 (sh)
MY (1) MY108831A (sh)
NO (1) NO177424C (sh)
NZ (1) NZ237189A (sh)
PL (6) PL168384B1 (sh)
PT (1) PT96937B (sh)
RU (1) RU2070884C1 (sh)
SG (1) SG47482A1 (sh)
SI (1) SI9110396B (sh)
SK (2) SK282407B6 (sh)
TN (1) TNSN91010A1 (sh)
UA (1) UA25969A1 (sh)
YU (1) YU48854B (sh)
ZA (1) ZA911611B (sh)
ZW (1) ZW2391A1 (sh)

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Also Published As

Publication number Publication date
FI911096A0 (fi) 1991-03-05
PL168693B1 (pl) 1996-03-29
TNSN91010A1 (fr) 1992-10-25
FI101622B (fi) 1998-07-31
EP0445862A2 (en) 1991-09-11
HU910706D0 (en) 1991-09-30
HRP930483A2 (en) 1995-12-31
KR910016744A (ko) 1991-11-05
HK1010727A1 (en) 1999-06-25
SG47482A1 (en) 1998-04-17
IL97018A0 (en) 1992-03-29
LTIP846A (en) 1995-02-27
LV10085A (lv) 1994-05-10
FI911096A7 (fi) 1991-09-07
AU7207991A (en) 1991-09-12
CN1038936C (zh) 1998-07-01
DE69132119D1 (de) 2000-05-25
GR3033461T3 (en) 2000-09-29
CN1054598A (zh) 1991-09-18
HUT60733A (en) 1992-10-28
MY108831A (en) 1996-11-30
CA2037575A1 (en) 1991-09-07
PL168811B1 (pl) 1996-04-30
PT96937B (pt) 1998-07-31
PT96937A (pt) 1991-10-31
NO910863D0 (no) 1991-03-05
PL289323A1 (en) 1992-03-09
NO177424C (no) 1995-09-13
IL97018A (en) 1995-11-27
SI9110396A (en) 1997-12-31
CS46091A3 (en) 1991-10-15
CY2235B1 (en) 2003-07-04
KR0177521B1 (ko) 1999-03-20
LV10085B (en) 1995-02-20
YU39691A (sh) 1994-06-10
MA22076A1 (fr) 1991-10-01
US5262418A (en) 1993-11-16
PL168384B1 (en) 1996-02-29
SI9110396B (sl) 2000-06-30
JP2601566B2 (ja) 1997-04-16
RU2070884C1 (ru) 1996-12-27
PL169238B1 (pl) 1996-06-28
GB9005014D0 (en) 1990-05-02
NO910863L (no) 1991-09-09
CZ286617B6 (cs) 2000-05-17
EP0445862A3 (en) 1992-05-20
BG93979A (bg) 1993-12-24
EP0445862B1 (en) 2000-04-19
HU221627B1 (hu) 2002-12-28
HRP930483B1 (en) 2001-04-30
LT3708B (en) 1996-02-26
JPH04211685A (ja) 1992-08-03
DK0445862T3 (da) 2000-09-04
ZW2391A1 (en) 1992-09-07
US5185335A (en) 1993-02-09
NZ237189A (en) 1992-11-25
ZA911611B (en) 1992-11-25
IE910710A1 (en) 1991-09-11
SK282406B6 (sk) 2002-01-07
ATE191912T1 (de) 2000-05-15
SK282407B6 (sk) 2002-01-07
FI101622B1 (fi) 1998-07-31
PL168356B1 (pl) 1996-02-29
NO177424B (no) 1995-06-06
PL168686B1 (pl) 1996-03-29
UA25969A1 (uk) 1999-02-26
CA2037575C (en) 2003-09-16
HU211350A9 (en) 1995-11-28
BG60381B1 (bg) 1995-01-31
ES2147175T3 (es) 2000-09-01
DE69132119T2 (de) 2000-12-21
AU636012B2 (en) 1993-04-08

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