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YU46319B - PROCESS FOR PREPARATION OF 1- / 3-MERCAPTO- / 2S / -METHYLPROPIONYL / -PYROLIDINE- / 2S / -CARBOXYLIC ACID - Google Patents

PROCESS FOR PREPARATION OF 1- / 3-MERCAPTO- / 2S / -METHYLPROPIONYL / -PYROLIDINE- / 2S / -CARBOXYLIC ACID

Info

Publication number
YU46319B
YU46319B YU118187A YU118187A YU46319B YU 46319 B YU46319 B YU 46319B YU 118187 A YU118187 A YU 118187A YU 118187 A YU118187 A YU 118187A YU 46319 B YU46319 B YU 46319B
Authority
YU
Yugoslavia
Prior art keywords
pyrolidine
methylpropionyl
mercapto
preparation
carboxylic acid
Prior art date
Application number
YU118187A
Other languages
Serbo-Croatian (sh)
Other versions
YU118187A (en
Inventor
J. Fischer
T. Fodor
L. Dobay
B. Stefko
Original Assignee
Egis Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar filed Critical Egis Gyogyszergyar
Publication of YU118187A publication Critical patent/YU118187A/en
Publication of YU46319B publication Critical patent/YU46319B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

naznačen time, što reaguje omega-halo-acilprolin formule gde X predstavlja halo, ili njegova so sa tioureom u organskom dipolarnom aprotičnom rastvaračom tako da daje izotiouronijum ili njegov hidrohalid, po izboru posle izolovanja, se hidrolizira i, ako se želi, proizvod formule I se prevodi u so ili se oslobadja iz soli. -Prijava sadrži još 7 zahteva.characterized in that it reacts with an omega-halo-acylproline of formula wherein X represents halo, or a thiourea salt thereof in an organic dipolar aprotic solvent to give isothiouronium or a hydrohalide thereof, optionally after isolation, is hydrolyzed and, if desired, the product of formula I is translated into salt or released from salt. -The application contains 7 more requests.

YU118187A 1986-06-27 1987-06-24 PROCESS FOR PREPARATION OF 1- / 3-MERCAPTO- / 2S / -METHYLPROPIONYL / -PYROLIDINE- / 2S / -CARBOXYLIC ACID YU46319B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862689A HU196959B (en) 1986-06-27 1986-06-27 Process for producing merkapto-acyl-proline derivatives

Publications (2)

Publication Number Publication Date
YU118187A YU118187A (en) 1988-04-30
YU46319B true YU46319B (en) 1993-05-28

Family

ID=10960651

Family Applications (1)

Application Number Title Priority Date Filing Date
YU118187A YU46319B (en) 1986-06-27 1987-06-24 PROCESS FOR PREPARATION OF 1- / 3-MERCAPTO- / 2S / -METHYLPROPIONYL / -PYROLIDINE- / 2S / -CARBOXYLIC ACID

Country Status (21)

Country Link
JP (1) JPS6327475A (en)
KR (1) KR900007217B1 (en)
CN (1) CN87104388A (en)
AR (1) AR243159A1 (en)
AT (2) AT395012B (en)
CH (1) CH673279A5 (en)
CS (1) CS276394B6 (en)
DD (1) DD263757A5 (en)
DE (1) DE3721430A1 (en)
DK (1) DK329787A (en)
ES (1) ES2004451A6 (en)
FI (1) FI87770C (en)
GR (1) GR871012B (en)
HU (1) HU196959B (en)
IT (1) IT1206792B (en)
NO (1) NO168941C (en)
PL (1) PL153449B1 (en)
PT (1) PT85190B (en)
SE (1) SE462751B (en)
SU (1) SU1650007A3 (en)
YU (1) YU46319B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE421551B (en) * 1980-03-26 1982-01-04 Sandvik Ab DRILLING TOOL FOR ROTATION AND / OR DRILLING
HU208954B (en) * 1990-09-21 1994-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn
JPS62125081A (en) * 1985-11-21 1987-06-06 キングプリンテイング株式会社 Printing method
IL129020A (en) * 1996-09-26 2004-06-20 Meditor Pharmaceutical Ltd Pharmaceutical compositions comprising s-alkylisothiouronium derivatives
CN103086939A (en) * 2011-10-28 2013-05-08 华中药业股份有限公司 Recrystallization method of 1-(3-bromo-2-D-methyl propionyl)pyrrolidine-2-carboxylic acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
GB2065643B (en) * 1979-12-13 1983-08-24 Kanegafuchi Chemical Ind Optically active n-mercaptoalkanoylamino acids
IE54551B1 (en) * 1982-01-22 1989-11-22 Ici Plc Amide derivatives
KR860001391B1 (en) * 1984-07-23 1986-09-22 보령제약 주식회사 Method for preparing pyrrolidine derivative

Also Published As

Publication number Publication date
JPS6327475A (en) 1988-02-05
SE8702654D0 (en) 1987-06-26
KR880000392A (en) 1988-03-25
FI872859A7 (en) 1987-12-28
SE8702654L (en) 1987-12-28
NO872690D0 (en) 1987-06-26
PT85190B (en) 1990-03-30
FI87770C (en) 1993-02-25
AR243159A1 (en) 1993-07-30
DK329787D0 (en) 1987-06-26
HU196959B (en) 1989-02-28
YU118187A (en) 1988-04-30
ES2004451A6 (en) 1989-01-01
NO168941B (en) 1992-01-13
CS479487A3 (en) 1992-01-15
AT387381B (en) 1989-01-10
FI872859A0 (en) 1987-06-26
DD263757A5 (en) 1989-01-11
IT1206792B (en) 1989-05-03
CN87104388A (en) 1988-03-02
AT395012B (en) 1992-08-25
FI87770B (en) 1992-11-13
SU1650007A3 (en) 1991-05-15
KR900007217B1 (en) 1990-10-05
DE3721430A1 (en) 1988-01-28
IT8721085A0 (en) 1987-06-26
HUT44490A (en) 1988-03-28
PL153449B1 (en) 1991-04-30
GR871012B (en) 1987-11-02
ATA162087A (en) 1988-06-15
SE462751B (en) 1990-08-27
CH673279A5 (en) 1990-02-28
DK329787A (en) 1987-12-28
PL266478A1 (en) 1988-06-09
ATA91186A (en) 1992-01-15
NO168941C (en) 1992-04-29
NO872690L (en) 1987-12-28
CS276394B6 (en) 1992-05-13
PT85190A (en) 1987-07-01

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