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YU37594A - Postupak za dobivanje oksazolidinkarboksilne kiseline koja se koristi za dobijanje terapetuski aktivnih taksoida - Google Patents

Postupak za dobivanje oksazolidinkarboksilne kiseline koja se koristi za dobijanje terapetuski aktivnih taksoida

Info

Publication number
YU37594A
YU37594A YU37594A YU37594A YU37594A YU 37594 A YU37594 A YU 37594A YU 37594 A YU37594 A YU 37594A YU 37594 A YU37594 A YU 37594A YU 37594 A YU37594 A YU 37594A
Authority
YU
Yugoslavia
Prior art keywords
denotes
radical
optionally substituted
general formula
phenyl
Prior art date
Application number
YU37594A
Other languages
English (en)
Inventor
J.D. Bourzat
Alain Commercon
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of YU37594A publication Critical patent/YU37594A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Postupak za dobivanje, polazeći od oksazolidinkarboksilne kiseline opšte formule (II), oksazolidinkarboksilne kiseline opšte formule (I) koja se može koristiti za dobivanje terapeutski aktivnih taksoida opšte formule (III). U formulama (I), (II) i (III), R označava atom vodonika ili radikal acetil, R1 oznacava radikal benzoil ili radikal opšte formule R2-O-CO-u kojoj R2 označava radikal alkil koji je u datom slučaju supstituisan, alkenil, alkinil, cikloalkil, cikloalkenil, bicik-loalkil, fenil ili hetrociklil, R3 i R4, idendčni ili različiti, označavaju vodonik, alkil, alkoksi, aril koji je u datom slučaju supstituisan, aralkil koji je u datom slučaju supstituisan ili zajedno formiraju ciklus sa 4 do 7 članova, R5 označava alkenil, alkinil, fenil, formil, alkanoil, aroil, hidroksimetil, karboksi ili alkiloksikarbonil, i R' označava atom vodonika ili atom alkalnog ili zemnoalkalnog metala ili radikal alkil koji sadrži 1 do 4 atoma ugljenika i koji je u datom slučaju supstituisan radikalom fenil.
YU37594A 1993-06-16 1994-06-16 Postupak za dobivanje oksazolidinkarboksilne kiseline koja se koristi za dobijanje terapetuski aktivnih taksoida YU37594A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9307240A FR2706457B1 (fr) 1993-06-16 1993-06-16 Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.

Publications (1)

Publication Number Publication Date
YU37594A true YU37594A (sh) 1997-03-07

Family

ID=9448182

Family Applications (1)

Application Number Title Priority Date Filing Date
YU37594A YU37594A (sh) 1993-06-16 1994-06-16 Postupak za dobivanje oksazolidinkarboksilne kiseline koja se koristi za dobijanje terapetuski aktivnih taksoida

Country Status (23)

Country Link
US (2) US6444825B1 (sh)
EP (1) EP0703907B1 (sh)
JP (1) JPH09500370A (sh)
KR (1) KR960703118A (sh)
AT (1) ATE156819T1 (sh)
AU (1) AU678585B2 (sh)
CA (1) CA2165328A1 (sh)
CZ (1) CZ284051B6 (sh)
DE (1) DE69404991T2 (sh)
DK (1) DK0703907T3 (sh)
ES (1) ES2107237T3 (sh)
FI (1) FI956025A7 (sh)
FR (1) FR2706457B1 (sh)
GR (1) GR3024534T3 (sh)
HU (1) HUT73972A (sh)
NO (1) NO955112D0 (sh)
NZ (1) NZ268037A (sh)
PL (1) PL312212A1 (sh)
RU (1) RU2128652C1 (sh)
SK (1) SK156995A3 (sh)
WO (1) WO1994029284A1 (sh)
YU (1) YU37594A (sh)
ZA (1) ZA943994B (sh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
CZ293480B6 (cs) 1996-05-08 2004-05-12 Pharmaciaá@Áupjohnácompany Oxazolidinové estery silylovaného baccatinu III
KR100225535B1 (ko) * 1996-08-27 1999-10-15 정지석 파클리탁셀의 제조방법
CA2422964A1 (en) 2000-09-22 2002-03-28 Bristol Myers Squibb Company Method for reducing toxicity of combined chemotherapies
WO2006055837A2 (en) * 2004-11-19 2006-05-26 Dr. Reddy's Laboratories Ltd. Process for preparing oxazolidine derivatives
WO2006102758A1 (en) * 2005-03-31 2006-10-05 Bioxel Pharma Inc. Preparation of taxanes from 9-dihydro-13-acetylbaccatin iii

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4240987A (en) * 1979-10-29 1980-12-23 Xerox Corporation Chemical process
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2696459B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696458B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2702212B1 (fr) * 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
AU7076294A (en) 1995-01-03
FR2706457A1 (fr) 1994-12-23
FR2706457B1 (fr) 1995-07-28
AU678585B2 (en) 1997-06-05
CZ329295A3 (en) 1996-03-13
US6043375A (en) 2000-03-28
CA2165328A1 (fr) 1994-12-22
WO1994029284A1 (fr) 1994-12-22
ES2107237T3 (es) 1997-11-16
RU2128652C1 (ru) 1999-04-10
FI956025A0 (fi) 1995-12-14
NZ268037A (en) 1997-11-24
SK156995A3 (en) 1996-06-05
KR960703118A (ko) 1996-06-19
NO955112L (no) 1995-12-15
DE69404991T2 (de) 1998-01-22
US6444825B1 (en) 2002-09-03
DE69404991D1 (de) 1997-09-18
DK0703907T3 (da) 1998-03-23
CZ284051B6 (cs) 1998-07-15
ZA943994B (en) 1995-02-03
EP0703907B1 (fr) 1997-08-13
EP0703907A1 (fr) 1996-04-03
HU9503611D0 (en) 1996-02-28
ATE156819T1 (de) 1997-08-15
PL312212A1 (en) 1996-04-01
GR3024534T3 (en) 1997-12-31
HUT73972A (en) 1996-10-28
JPH09500370A (ja) 1997-01-14
NO955112D0 (no) 1995-12-15
FI956025A7 (fi) 1995-12-14

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