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YU36693A - Derivati eritromicina - Google Patents

Derivati eritromicina

Info

Publication number
YU36693A
YU36693A YU36693A YU36693A YU36693A YU 36693 A YU36693 A YU 36693A YU 36693 A YU36693 A YU 36693A YU 36693 A YU36693 A YU 36693A YU 36693 A YU36693 A YU 36693A
Authority
YU
Yugoslavia
Prior art keywords
hydrogen atom
group
lower alkyl
erythromycin derivatives
atom
Prior art date
Application number
YU36693A
Other languages
English (en)
Other versions
YU48771B (sh
Inventor
H. Koga
T. Sato
H. Takanashi
Original Assignee
Chugai Seiyuaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyuaku Kabushiki Kaisha filed Critical Chugai Seiyuaku Kabushiki Kaisha
Publication of YU36693A publication Critical patent/YU36693A/sh
Publication of YU48771B publication Critical patent/YU48771B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

DERIVATI ERITROMICINA, jedinjenje predstavljeno opštom formulom gde R1 je atom vodonika ili acil grupa, R2 i R3 mogu biti isti ili različiti i svaki je atom vodonika, acil, aciloksi ili amino grupa ili zajedno grade =O ili =NDR10 gde R10 je atom vodonika ili niža alkil grupa, R4 je atom vodonika ili niža alkil grupa i Y predstavlja -NR5R6 ili -N+R7R8R9X-, gde R5, R6, R7, R8 i R9 mogu biti isti ili različiti i svaki je atom vodonika ili niža alkil, alkenil ili alkinil grupa koja može biti supstituisana ili 3-7člana cikloalkil grupa koja može da sadrži atom kiseonika, azota ili sumpora kao heteroatom i X predstavlja anjom, gde R5 i R6 i R7 i R8 mogu da grade azacikloalkil grupu zajedno sa susednim atomom azota, i njihove soli. Ova jedinjenja i njihove soli u znatno manjem stepenu podležu razlaganju pod dejstvom stomačne kiseline od dosada poznatih derivata eritromicina i poseduju izvanredno enterolikinezi stimulišući dejstvo.
YU36693A 1992-05-26 1993-05-25 Derivati eritromicina YU48771B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13382892 1992-05-26

Publications (2)

Publication Number Publication Date
YU36693A true YU36693A (sh) 1996-07-24
YU48771B YU48771B (sh) 1999-12-27

Family

ID=15113997

Family Applications (1)

Application Number Title Priority Date Filing Date
YU36693A YU48771B (sh) 1992-05-26 1993-05-25 Derivati eritromicina

Country Status (20)

Country Link
US (1) US5658888A (sh)
EP (1) EP0643068B1 (sh)
JP (1) JP3068367B2 (sh)
KR (1) KR100226311B1 (sh)
CN (1) CN1036199C (sh)
AT (1) ATE169927T1 (sh)
AU (1) AU659740B2 (sh)
CA (1) CA2117883C (sh)
DE (1) DE69320476T2 (sh)
DK (1) DK0643068T3 (sh)
ES (1) ES2120499T3 (sh)
HR (1) HRP930926B1 (sh)
IL (1) IL105810A (sh)
MY (1) MY113693A (sh)
SG (1) SG52785A1 (sh)
SI (1) SI9300281B (sh)
TW (1) TW240230B (sh)
WO (1) WO1993024509A1 (sh)
YU (1) YU48771B (sh)
ZA (1) ZA933679B (sh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA966601B (en) * 1995-08-03 1997-02-19 Chugai Pharmaceutical Co Ltd Process for producing erythromycin derivatives.
JP2007204490A (ja) * 1995-08-03 2007-08-16 Chugai Pharmaceut Co Ltd エリスロマイシン誘導体の製造方法
US6077943A (en) * 1996-03-01 2000-06-20 Takeda Chemical Industries, Ltd. Method of producing erythromycin derivative
WO1998003531A1 (fr) * 1996-07-24 1998-01-29 Chugai Seiyaku Kabushiki Kaisha Derives d'erythromycine
AU4968997A (en) * 1996-11-26 1998-06-22 Chugai Seiyaku Kabushiki Kaisha 13-membered ring macrolide compounds, medicine containing the same, and process for producing the same
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
AU2001238476A1 (en) 2000-02-18 2001-08-27 Kosan Biosciences, Inc. Motocide compounds
JP3944077B2 (ja) * 2000-09-01 2007-07-11 中外製薬株式会社 エリスロマイシン誘導体の製造方法
TWI286139B (en) 2000-10-12 2007-09-01 Chugai Pharmaceutical Co Ltd Erythromycin derivative having novel crystal structures and processes for their production
US6906039B2 (en) 2001-06-13 2005-06-14 Ube Industries, Ltd. Process for preparation of erythromycin compounds
TW200302830A (en) * 2002-01-11 2003-08-16 Chugai Pharmaceutical Co Ltd Anhydrate/hydrate of an erythromycin derivative and processes for preparing said anhydrate/hydrate
EP2316469A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
US20040010035A1 (en) * 2002-07-15 2004-01-15 Ciociola Arthur A. Gastrointestinal compositions
AU2003281172A1 (en) * 2002-07-10 2004-02-02 Warner-Lambert Company Llc Gastrointestinal Compositions
US6986901B2 (en) * 2002-07-15 2006-01-17 Warner-Lambert Company Llc Gastrointestinal compositions
SI1532131T1 (sl) * 2002-08-29 2009-04-30 Pfizer Motilidne spojine
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
CN1780846A (zh) * 2003-03-05 2006-05-31 Rib－X医药品有限公司 双官能杂环化合物及其制备和使用方法
CA2528375C (en) 2003-06-18 2013-11-19 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
JP2007509980A (ja) * 2003-10-30 2007-04-19 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環式化合物およびそれらの化合物を調製および使用する方法
JP2007512256A (ja) * 2003-11-18 2007-05-17 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
US7211568B2 (en) * 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
JP5383037B2 (ja) 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 大環状化合物およびそれらを製造し使用する方法
TW200633714A (en) * 2004-12-28 2006-10-01 Chugai Pharmaceutical Co Ltd Drugs for the treatment and/or prophylaxis of gastroparesis symptom
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
EP1934237A2 (en) 2005-08-24 2008-06-25 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
EP1928893A2 (en) 2005-08-24 2008-06-11 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
JP2009518396A (ja) * 2005-12-08 2009-05-07 ファイザー・インク エリスロマイシン化合物の３’−ジメチルアミノ基を脱メチルする方法
JP5684474B2 (ja) 2006-09-11 2015-03-11 オセラ セラピューティクス， インコーポレイテッド 胃腸の運動障害疾患の治療のためのモチリン受容体の大環状アンタゴニスト
RU2422453C2 (ru) * 2006-12-05 2011-06-27 Пфайзер Инк. Полиморфы мотилида
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60218321A (ja) * 1984-04-13 1985-11-01 Satoshi Omura 消化管収縮運動促進剤
JPS6187625A (ja) * 1984-10-05 1986-05-06 Satoshi Omura 消化管収縮運動促進剤
JPH0759513B2 (ja) * 1985-08-31 1995-06-28 北里研究所（社団法人） 消化管収縮運動促進剤
EP0215355B1 (en) * 1985-08-31 1994-04-06 Kitasato Kenkyusho Erythromycin derivative and process for preparing the same
US5008249A (en) * 1985-08-31 1991-04-16 Kitasato Kenkyusho Therapeutic method of stimulating digestive tract contractile motion in mammals
ATE164848T1 (de) * 1992-01-21 1998-04-15 Abbott Lab 4''-deoxyerythromycinderivate

Also Published As

Publication number Publication date
CA2117883C (en) 2003-10-21
US5658888A (en) 1997-08-19
CN1081184A (zh) 1994-01-26
IL105810A0 (en) 1993-09-22
SI9300281A (sl) 1993-12-31
HRP930926B1 (en) 2000-10-31
TW240230B (sh) 1995-02-11
IL105810A (en) 1998-12-27
ES2120499T3 (es) 1998-11-01
DE69320476T2 (de) 1999-03-25
MY113693A (en) 2002-05-31
DK0643068T3 (da) 1999-02-08
ATE169927T1 (de) 1998-09-15
DE69320476D1 (en) 1998-09-24
SG52785A1 (en) 1998-09-28
EP0643068A4 (en) 1995-08-02
HK1009969A1 (en) 1999-09-10
HRP930926A2 (en) 1995-02-28
CA2117883A1 (en) 1993-12-09
JP3068367B2 (ja) 2000-07-24
AU4089793A (en) 1993-12-30
SI9300281B (en) 2001-02-28
JPH0656873A (ja) 1994-03-01
WO1993024509A1 (fr) 1993-12-09
EP0643068A1 (en) 1995-03-15
ZA933679B (en) 1993-12-21
EP0643068B1 (en) 1998-08-19
CN1036199C (zh) 1997-10-22
KR950701640A (ko) 1995-04-28
AU659740B2 (en) 1995-05-25
KR100226311B1 (ko) 1999-10-15
YU48771B (sh) 1999-12-27

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