YU34400A - Conjugates useful in the treatment of prostate cancer - Google Patents
Conjugates useful in the treatment of prostate cancerInfo
- Publication number
- YU34400A YU34400A YU34400A YU34400A YU34400A YU 34400 A YU34400 A YU 34400A YU 34400 A YU34400 A YU 34400A YU 34400 A YU34400 A YU 34400A YU 34400 A YU34400 A YU 34400A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- conjugates
- treatment
- prostate cancer
- conjugates useful
- useful
- Prior art date
Links
- 206010060862 Prostate cancer Diseases 0.000 title abstract 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 title abstract 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 2
- 102000015636 Oligopeptides Human genes 0.000 abstract 2
- 108010038807 Oligopeptides Proteins 0.000 abstract 2
- 102000007066 Prostate-Specific Antigen Human genes 0.000 abstract 2
- 108010072866 Prostate-Specific Antigen Proteins 0.000 abstract 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 2
- 241000863480 Vinca Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be desacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6711097P | 1997-12-02 | 1997-12-02 | |
| GBGB9804399.5A GB9804399D0 (en) | 1998-03-02 | 1998-03-02 | Conjugates useful in the treatment of prostate cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU34400A true YU34400A (en) | 2002-08-12 |
Family
ID=10827842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU34400A YU34400A (en) | 1997-12-02 | 1998-11-25 | Conjugates useful in the treatment of prostate cancer |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB9804399D0 (en) |
| YU (1) | YU34400A (en) |
-
1998
- 1998-03-02 GB GBGB9804399.5A patent/GB9804399D0/en not_active Ceased
- 1998-11-25 YU YU34400A patent/YU34400A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9804399D0 (en) | 1998-04-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO1998018493A3 (en) | Conjugates useful in the treatment of prostate cancer | |
| BG104563A (en) | Conjugates useful in the treatment of prostate cancer | |
| EP1009420A4 (en) | CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER | |
| WO2000066175A3 (en) | Conjugates as therapies for cancer and prostate diseases | |
| HU9603564D0 (en) | Novel peptides | |
| AU6045398A (en) | Androgen synthesis inhibitors | |
| GEP20074122B (en) | Treating benign prostate hyperplasia with selective androgen receptor modulators | |
| WO2003018611A3 (en) | Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer | |
| NO20020348L (en) | Peptide acceptor ligation methods | |
| AU2630701A (en) | Activators of caspases | |
| IS2012B (en) | Quinoline and quinazoline compounds useful in the treatment, especially for the treatment of benign prostatic hyperplasia | |
| HUP0100586A2 (en) | Pharmaceutical compositions treating lower urinary tract symptoms | |
| AU8812498A (en) | Chimeric polypeptide comprising the fragment b of shiga toxin and peptides of therapeutic interest | |
| EP1496116A4 (en) | Anticancer agents using vero toxin variants | |
| ATE548380T1 (en) | MUTANT OF THE HGF PRECURSOR PROTEIN AND ACTIVATED FORM THEREOF | |
| DE60023683D1 (en) | METHOD FOR THE DISTINCTION OF PROSTATE CANCER AND GOOD PROSTATE HYPERPLASIA | |
| YU34400A (en) | Conjugates useful in the treatment of prostate cancer | |
| TR200000903T2 (en) | Methods and compositions for the treatment of rheumatic arteritis. | |
| ZA991315B (en) | Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia. | |
| WO1999044628A8 (en) | Conjugates useful in the treatment of prostate cancer | |
| GB2411404A (en) | Biologically active peptide conjugates | |
| FR2812200B1 (en) | COMPOSITION CONTAINING AN IRON COMPLEXING PROTEIN AND A NITROGEN MONOXIDE METABOLISM PRECURSOR AND / OR A NITROGEN MONOXIDE CHEMICAL DONOR; AND USES | |
| ECSP982763A (en) | USEFUL CONJUGATES IN THE TREATMENT OF CANCER OF PROSTATE | |
| ECSP972297A (en) | HELPFUL CONJUGATES IN THE TREATMENT OF CANCER OF PROSTATE | |
| ZA991319B (en) | Novel phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia. |