YU22401A - Kombinacija acetildinalina sa gemcitabinom, capecitabinom i cisplatinom - Google Patents
Kombinacija acetildinalina sa gemcitabinom, capecitabinom i cisplatinomInfo
- Publication number
- YU22401A YU22401A YU22401A YU22401A YU22401A YU 22401 A YU22401 A YU 22401A YU 22401 A YU22401 A YU 22401A YU 22401 A YU22401 A YU 22401A YU 22401 A YU22401 A YU 22401A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- combination
- capecytabine
- acetyldynaline
- cisplatinium
- gemcytabine
- Prior art date
Links
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 title abstract 2
- 229960004117 capecitabine Drugs 0.000 title abstract 2
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003560 cancer drug Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
- 229960004316 cisplatin Drugs 0.000 abstract 1
- 229960005277 gemcitabine Drugs 0.000 abstract 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011885 synergistic combination Substances 0.000 abstract 1
- VAZAPHZUAVEOMC-UHFFFAOYSA-N tacedinaline Chemical compound C1=CC(NC(=O)C)=CC=C1C(=O)NC1=CC=CC=C1N VAZAPHZUAVEOMC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Acetildinalin, u kombinaciji sa gemcitabinom, njegovom farmaceutski prihvatljivom solju, capecitabinom ili cisplatinom, je sinergična kombinacija agenasa koja se koristi za dobijanje leka za kancer
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10180998P | 1998-09-25 | 1998-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU22401A true YU22401A (sh) | 2004-03-12 |
Family
ID=22286531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU22401A YU22401A (sh) | 1998-09-25 | 1999-07-08 | Kombinacija acetildinalina sa gemcitabinom, capecitabinom i cisplatinom |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US6469058B1 (sh) |
| EP (1) | EP1115391B1 (sh) |
| JP (1) | JP2002525320A (sh) |
| KR (1) | KR20010075348A (sh) |
| CN (1) | CN1319009A (sh) |
| AP (1) | AP2001002109A0 (sh) |
| AT (1) | ATE225655T1 (sh) |
| AU (1) | AU762079B2 (sh) |
| BG (1) | BG105470A (sh) |
| BR (1) | BR9913952A (sh) |
| CA (1) | CA2342981A1 (sh) |
| CZ (1) | CZ2001905A3 (sh) |
| DE (1) | DE69903458T2 (sh) |
| DK (1) | DK1115391T3 (sh) |
| EA (1) | EA200100369A1 (sh) |
| EE (1) | EE200100187A (sh) |
| ES (1) | ES2185378T3 (sh) |
| GE (1) | GEP20043199B (sh) |
| HK (1) | HK1040190A1 (sh) |
| HR (1) | HRP20010225B1 (sh) |
| HU (1) | HUP0103640A3 (sh) |
| ID (1) | ID30046A (sh) |
| IL (1) | IL141951A0 (sh) |
| IS (1) | IS5888A (sh) |
| NO (1) | NO20011493L (sh) |
| NZ (1) | NZ510504A (sh) |
| OA (1) | OA11659A (sh) |
| PL (1) | PL348673A1 (sh) |
| PT (1) | PT1115391E (sh) |
| SK (1) | SK3602001A3 (sh) |
| TR (1) | TR200100859T2 (sh) |
| WO (1) | WO2000018393A1 (sh) |
| YU (1) | YU22401A (sh) |
| ZA (1) | ZA200102233B (sh) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU22401A (sh) * | 1998-09-25 | 2004-03-12 | Warner-Lambert Company | Kombinacija acetildinalina sa gemcitabinom, capecitabinom i cisplatinom |
| CZ20022216A3 (cs) * | 2001-07-02 | 2003-05-14 | Warner-Lambert Company | Kombinační chemoterapie |
| US20080075762A1 (en) * | 2001-10-03 | 2008-03-27 | Paul Tardi | Compositions for delivery of drug combinations |
| CA2383259A1 (en) | 2002-04-23 | 2003-10-23 | Celator Technologies Inc. | Synergistic compositions |
| US7850990B2 (en) * | 2001-10-03 | 2010-12-14 | Celator Pharmaceuticals, Inc. | Compositions for delivery of drug combinations |
| US20040132825A1 (en) * | 2002-03-04 | 2004-07-08 | Bacopoulos Nicholas G. | Methods of treating cancer with HDAC inhibitors |
| CA2632078C (en) * | 2002-03-04 | 2012-08-14 | Sloan-Kettering Institute For Cancer Research | Methods of inducing terminal differentiation |
| US7456219B2 (en) * | 2002-03-04 | 2008-11-25 | Merck Hdac Research, Llc | Polymorphs of suberoylanilide hydroxamic acid |
| MXPA04010199A (es) * | 2002-04-15 | 2005-07-05 | Sloan Kettering Inst Cancer | Terapia en combinacion para el tratamiento de cancer. |
| US20070032422A1 (en) | 2002-10-24 | 2007-02-08 | Spectrum Pharmaceuticals, Inc. | Methods, compositions and articles of manufacture for contributing to the treatment of cancers |
| US8026216B2 (en) | 2002-10-24 | 2011-09-27 | Spectrum Pharmaceuticals, Inc. | Methods and compositions for contributing to the treatment of cancers |
| GB0226434D0 (en) * | 2002-11-13 | 2002-12-18 | Astrazeneca Ab | Combination product |
| CA2506085A1 (en) * | 2002-11-15 | 2004-06-03 | Ronald Lynn Merriman | Combination chemotherapy comprising a mek inhibitor and capecitabine for treating cancer |
| RU2240117C1 (ru) * | 2003-04-01 | 2004-11-20 | Алтайский государственный медицинский университет | Способ лечения больных с местнораспространенными формами плоскоклеточного рака с локализацией в области слизистой оболочки полости рта и ротового отдела глотки |
| EP1643971A2 (en) * | 2003-05-22 | 2006-04-12 | Neopharm, Inc. | Liposomal formulations comprising a combination of two or more active agents |
| PE20050206A1 (es) * | 2003-05-26 | 2005-03-26 | Schering Ag | Composicion farmaceutica que contiene un inhibidor de histona deacetilasa |
| CN100431606C (zh) * | 2004-11-22 | 2008-11-12 | 山东蓝金生物工程有限公司 | 一种抗癌药物组合物 |
| US7957507B2 (en) | 2005-02-28 | 2011-06-07 | Cadman Patrick F | Method and apparatus for modulating a radiation beam |
| CN100443081C (zh) * | 2005-04-05 | 2008-12-17 | 吴一心 | 木犀草素与一种铂类化疗药物联合用于制备抗肿瘤的药物 |
| US8232535B2 (en) | 2005-05-10 | 2012-07-31 | Tomotherapy Incorporated | System and method of treating a patient with radiation therapy |
| CA2616306A1 (en) | 2005-07-22 | 2007-02-01 | Tomotherapy Incorporated | Method and system for processing data relating to a radiation therapy treatment plan |
| AU2006272742A1 (en) | 2005-07-22 | 2007-02-01 | Tomotherapy Incorporated | System and method of delivering radiation therapy to a moving region of interest |
| US8442287B2 (en) | 2005-07-22 | 2013-05-14 | Tomotherapy Incorporated | Method and system for evaluating quality assurance criteria in delivery of a treatment plan |
| JP2009502252A (ja) | 2005-07-22 | 2009-01-29 | トモセラピー・インコーポレーテッド | 生物学的モデルに基づいて放射線療法治療プランを適合させるための方法およびシステム |
| KR20080039919A (ko) | 2005-07-22 | 2008-05-07 | 토모테라피 인코포레이티드 | 방사선 치료를 받는 환자의 호흡 상태를 검출하는 시스템및 방법 |
| JP2009514559A (ja) | 2005-07-22 | 2009-04-09 | トモセラピー・インコーポレーテッド | 線量体積ヒストグラムを用いて輪郭構造を生成するシステムおよび方法 |
| CA2616299A1 (en) | 2005-07-22 | 2007-02-01 | Tomotherapy Incorporated | Method of placing constraints on a deformation map and system for implementing same |
| EP1907968A4 (en) * | 2005-07-22 | 2009-10-21 | Tomotherapy Inc | METHOD AND SYSTEM FOR EVALUATING QUALITY ASSURANCE CRITERIA FOR A TREATMENT ADMINISTRATION PROGRAM |
| CA2616309A1 (en) | 2005-07-22 | 2007-02-01 | Tomotherapy Incorporated | Method of and system for predicting dose delivery |
| JP2009502251A (ja) | 2005-07-22 | 2009-01-29 | トモセラピー・インコーポレーテッド | 放射線治療システムによって送達された線量を評価するシステム及び方法 |
| AU2006272746A1 (en) | 2005-07-22 | 2007-02-01 | Tomotherapy Incorporated | Method and system for evaluating delivered dose |
| CN101267767A (zh) | 2005-07-23 | 2008-09-17 | 断层放疗公司 | 使用机架和治疗床的协同运动的放射疗法成像和实施 |
| RU2009111605A (ru) * | 2006-08-31 | 2010-10-10 | Спектрум Фармасьютикалз, Инк. (Us) | Сенсибилизация опухолевых клеток к лучевой терапии посредством введения агонистов эндотелина |
| CN104689336A (zh) * | 2008-01-28 | 2015-06-10 | 那野伽利阿株式会社 | 医药组合物或组合剂 |
| FR2937867B1 (fr) * | 2008-11-03 | 2011-03-04 | Biorebus | Association pharmaceutique contenant l acide lipoique et l acide hydroxycitrique a titre de principes actifs. |
| ES2593088T3 (es) | 2009-04-06 | 2016-12-05 | Otsuka Pharmaceutical Co., Ltd. | Derivados de (2'-Desoxi-Ribofuranosil)-1,3,4,7-Tetrahidro-(1,3)Diazepin-2-ona para Tratamiento de Cáncer |
| WO2012003413A1 (en) * | 2010-06-30 | 2012-01-05 | The Broad Institute, Inc. | Novel solid forms of tacedinaline |
| US8729130B2 (en) | 2011-07-01 | 2014-05-20 | The Broad Institute, Inc. | Methods of using novel solid forms of tacedinaline |
| US9308235B2 (en) | 2012-05-09 | 2016-04-12 | Spectrum Pharmaceuticals, Inc. | Treatment of primary and metastatic carcinoma |
| EP2711008A1 (en) | 2012-09-19 | 2014-03-26 | Institut Univ. de Ciència i Tecnologia, S.A. | N6,N6-dimethyladenosine for use in treating or preventing primary and metastatic breast cancer |
| EP2711007A1 (en) | 2012-09-19 | 2014-03-26 | Institut Univ. de Ciència i Tecnologia, S.A. | 4-Aminopyrazolo[3,4-d]pyrimidine for use in treating or preventing primary and metastatic breast and prostate cancer |
| EP2711009A1 (en) | 2012-09-19 | 2014-03-26 | Institut Univ. de Ciència i Tecnologia, S.A. | Compounds for use in treating or preventing primary and metastatic breast and prostate cancer |
| CN105027227B (zh) | 2013-02-26 | 2017-09-08 | 安科锐公司 | 电磁致动的多叶准直器 |
| US10189797B2 (en) * | 2015-12-30 | 2019-01-29 | Duke University | Chemical modulators of immune checkpoints and therapeutic use |
| WO2020028392A1 (en) | 2018-07-30 | 2020-02-06 | Duke University | Niclosamide analogues and therapeutic use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5562925A (en) * | 1970-04-20 | 1996-10-08 | Research Corporation Tech. Inc. | Anti-tumor method |
| NZ219974A (en) * | 1986-04-22 | 1989-08-29 | Goedecke Ag | N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases |
| AU671491B2 (en) * | 1992-12-18 | 1996-08-29 | F. Hoffmann-La Roche Ag | N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines |
| WO1998047500A1 (en) * | 1997-04-24 | 1998-10-29 | Warner-Lambert Company | Use of acetyldinaline for the manufacture of a medicament for the treatment of renal cell carcinoma |
| US5972986A (en) * | 1997-10-14 | 1999-10-26 | G.D. Searle & Co. | Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia |
| YU22401A (sh) * | 1998-09-25 | 2004-03-12 | Warner-Lambert Company | Kombinacija acetildinalina sa gemcitabinom, capecitabinom i cisplatinom |
-
1999
- 1999-07-08 YU YU22401A patent/YU22401A/sh unknown
- 1999-07-08 TR TR2001/00859T patent/TR200100859T2/xx unknown
- 1999-07-08 HR HR20010225A patent/HRP20010225B1/xx not_active Application Discontinuation
- 1999-07-08 CA CA002342981A patent/CA2342981A1/en not_active Abandoned
- 1999-07-08 IL IL14195199A patent/IL141951A0/xx unknown
- 1999-07-08 OA OA1200100078A patent/OA11659A/en unknown
- 1999-07-08 GE GEAP19995872A patent/GEP20043199B/en unknown
- 1999-07-08 NZ NZ510504A patent/NZ510504A/en unknown
- 1999-07-08 CN CN99811320A patent/CN1319009A/zh active Pending
- 1999-07-08 AT AT99935442T patent/ATE225655T1/de not_active IP Right Cessation
- 1999-07-08 JP JP2000571912A patent/JP2002525320A/ja active Pending
- 1999-07-08 EP EP99935442A patent/EP1115391B1/en not_active Expired - Lifetime
- 1999-07-08 ES ES99935442T patent/ES2185378T3/es not_active Expired - Lifetime
- 1999-07-08 HU HU0103640A patent/HUP0103640A3/hu unknown
- 1999-07-08 EE EEP200100187A patent/EE200100187A/xx unknown
- 1999-07-08 CZ CZ2001905A patent/CZ2001905A3/cs unknown
- 1999-07-08 DK DK99935442T patent/DK1115391T3/da active
- 1999-07-08 AU AU50921/99A patent/AU762079B2/en not_active Ceased
- 1999-07-08 EA EA200100369A patent/EA200100369A1/ru unknown
- 1999-07-08 BR BR9913952-9A patent/BR9913952A/pt not_active IP Right Cessation
- 1999-07-08 HK HK02101589.3A patent/HK1040190A1/zh unknown
- 1999-07-08 PL PL99348673A patent/PL348673A1/xx not_active Application Discontinuation
- 1999-07-08 WO PCT/US1999/015386 patent/WO2000018393A1/en not_active Ceased
- 1999-07-08 PT PT99935442T patent/PT1115391E/pt unknown
- 1999-07-08 US US09/744,130 patent/US6469058B1/en not_active Expired - Fee Related
- 1999-07-08 KR KR1020017003794A patent/KR20010075348A/ko not_active Withdrawn
- 1999-07-08 SK SK360-2001A patent/SK3602001A3/sk unknown
- 1999-07-08 AP APAP/P/2001/002109A patent/AP2001002109A0/en unknown
- 1999-07-08 ID IDW20010901A patent/ID30046A/id unknown
- 1999-07-08 DE DE69903458T patent/DE69903458T2/de not_active Expired - Fee Related
-
2001
- 2001-03-14 IS IS5888A patent/IS5888A/is unknown
- 2001-03-16 ZA ZA200102233A patent/ZA200102233B/en unknown
- 2001-03-23 NO NO20011493A patent/NO20011493L/no not_active Application Discontinuation
- 2001-04-25 BG BG105470A patent/BG105470A/xx unknown
-
2002
- 2002-10-08 US US10/184,309 patent/US20030170300A1/en not_active Abandoned
- 2002-10-09 US US10/185,221 patent/US20030086965A1/en not_active Abandoned
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