YU201190A - NEW TRIAZOLYLHYDRAZIDE DERIVATIVES AND PROCEDURE FOR THEIR MAKING - Google Patents
NEW TRIAZOLYLHYDRAZIDE DERIVATIVES AND PROCEDURE FOR THEIR MAKINGInfo
- Publication number
- YU201190A YU201190A YU201190A YU201190A YU201190A YU 201190 A YU201190 A YU 201190A YU 201190 A YU201190 A YU 201190A YU 201190 A YU201190 A YU 201190A YU 201190 A YU201190 A YU 201190A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- formula
- alkyl
- triazolylhydrazide
- derivatives
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
- G11B33/00—Constructional parts, details or accessories not provided for in the other groups of this subclass
- G11B33/02—Cabinets; Cases; Stands; Disposition of apparatus therein or thereon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
- G11B20/00—Signal processing not specific to the method of recording or reproducing; Circuits therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Signal Processing (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Reinforced Plastic Materials (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
NOVI TRIAZOLILHIDRAZIDNI DERIVATI I POSTUPAK ZA NJIHOVO PRAVLJENJE, ovaj pronalazak odnosi se na nove triazolilhidrazidne derivate i na postupak za njihovo pravljenje. Novi triazolilhidrazidni derivati opšte formule (I) pri čemu u formuli: Q predstavlja vodonik ili heterocikličnu grupu koja je opciono supstituisana sa C1-4 alkil grupom; ili grupu formule SR1, gde R1 predstavlja C1-4 alkil ili fenil-(C1-4alkil) koji je opciono supstituisan sa halogenom, C1-4 alkil ili nitro supstituentima; ili grupa opšte formule NR2R3 u kojoj R2 i R3 svaki predstavlja vodonik, C1-6 alkil ili C2-6 alkenil pravog ili račvastog niza ili C2-6 alkenil; Z predstavlja vodonik ili grupu formule (C=X)-(N-R4)-NR5R6, gde X predstavlja kiseonik ili sumpor, R4, R5 i R6 svaki predstavlja vodonik ili C1-4 alkil; R7 predstavlja vodonik C1-4alkil ili fenil-(C1-4alkil) koji je opciono supstituisan sa jednim ili više halogenskih atoma ili sa amino grupom koja je opciono supstituisana sa jednim ili dva C1-4 alkil supstituenta, R8 predstavlja vodonik ili grupu formule -(C=X)-(N-R4)NR5R6, gde su X, R4, R5 i R6 kao što je naznačeno gore, pod uslovom da ako Z predstavlja grupu formule -(C=X)-(N-R4)-NR5R6, R8 predstavlja vodonik, a ako Z predstavlja vodonik, R8 predstavlja grupu formule (C=X)-(N-R4)-NR5R6, i njihove farmaceutski prihvatljive adicione soli sa kiselinama, ispoljavaju dragocene osobine za inhibiranje stomačnog ulcera i korisni su u terapiji.NEW TRIAZOLYLHYDRAZIDE DERIVATIVES AND PROCESS FOR THEIR MAKING, the present invention relates to new triazolylhydrazide derivatives and to a process for their production. Novel triazolylhydrazide derivatives of general formula (I) wherein in formula: Q represents hydrogen or a heterocyclic group optionally substituted by a C 1-4 alkyl group; or a group of formula SR1, wherein R1 represents C1-4 alkyl or phenyl- (C1-4alkyl) which is optionally substituted by halogen, C1-4 alkyl or nitro substituents; or a group of general formula NR2R3 wherein R2 and R3 each represent hydrogen, C1-6 alkyl or C2-6 alkenyl straight or branched chain or C2-6 alkenyl; Z represents hydrogen or a group of formula (C = X) - (N-R4) -NR5R6, wherein X represents oxygen or sulfur, R4, R5 and R6 each represent hydrogen or C1-4 alkyl; R7 represents hydrogen C1-4alkyl or phenyl- (C1-4alkyl) optionally substituted by one or more halogen atoms or by an amino group optionally substituted by one or two C1-4 alkyl substituents, R8 represents hydrogen or a group of formula - ( C = X) - (N-R4) NR5R6, wherein X, R4, R5 and R6 are as defined above, provided that if Z represents a group of the formula - (C = X) - (N-R4) -NR5R6, R8 represents hydrogen, and if Z represents hydrogen, R8 represents a group of the formula (C = X) - (N-R4) -NR5R6, and their pharmaceutically acceptable acid addition salts, exhibit valuable properties for inhibiting gastric ulcer and are useful in therapy.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU895428A HU206095B (en) | 1989-10-25 | 1989-10-25 | Process for producing triazolylcarboxylc acid hydrazie and semicarbazide derivatives and pharmaceutical compositions comprising same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU201190A true YU201190A (en) | 1993-10-20 |
| YU47564B YU47564B (en) | 1995-10-03 |
Family
ID=10970291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU201190A YU47564B (en) | 1989-10-25 | 1990-10-25 | TRIAZOLYLHYDRAZIDE DERIVATIVES AND THE PROCEDURE FOR THEIR MANAGEMENT |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5225410A (en) |
| EP (1) | EP0425283B1 (en) |
| JP (1) | JPH03246282A (en) |
| KR (1) | KR910007895A (en) |
| CN (1) | CN1051173A (en) |
| AT (1) | ATE122343T1 (en) |
| BG (1) | BG51044A3 (en) |
| DE (2) | DE69019294T4 (en) |
| DK (1) | DK0425283T3 (en) |
| ES (1) | ES2076334T3 (en) |
| FI (1) | FI905254A7 (en) |
| HU (1) | HU206095B (en) |
| IL (1) | IL96126A (en) |
| IN (1) | IN171608B (en) |
| PL (1) | PL164879B1 (en) |
| RU (1) | RU2039051C1 (en) |
| YU (1) | YU47564B (en) |
| ZA (1) | ZA908557B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100357278C (en) * | 2000-12-22 | 2007-12-26 | 奥索-麦克尼尔药品公司 | Substituted triazole diamine derivatives as kinase inhibitors |
| DE10126072C1 (en) | 2001-05-28 | 2002-11-28 | Martin Hofer Gmbh | Shock absorber for a vehicle comprises a piston in a cylinder, a spring device consisting of a main spring and a secondary spring, and a height-adjustable intermediate spring plate |
| JP4788181B2 (en) * | 2005-04-13 | 2011-10-05 | パナソニック株式会社 | Display panel assembly equipment |
| JP4710410B2 (en) * | 2005-05-10 | 2011-06-29 | パナソニック株式会社 | Panel connector joining apparatus and joining method |
| US8557178B2 (en) | 2010-12-21 | 2013-10-15 | Ecolab Usa Inc. | Corrosion inhibition of hypochlorite solutions in saturated wipes |
| US8603392B2 (en) | 2010-12-21 | 2013-12-10 | Ecolab Usa Inc. | Electrolyzed water system |
| US8114344B1 (en) | 2010-12-21 | 2012-02-14 | Ecolab Usa Inc. | Corrosion inhibition of hypochlorite solutions using sugar acids and Ca |
| CN103923033B (en) * | 2013-01-14 | 2015-11-18 | 天津药物研究院 | There is the piperazine derivative of anti-ulcer effect |
| CN110408048B (en) * | 2019-09-04 | 2021-06-22 | 中国工程物理研究院化工材料研究所 | Insensitive energetic metal organic framework and preparation method thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2352944A (en) * | 1942-07-04 | 1944-07-04 | Gen Electric | Triazole derivatives |
| FR1193374A (en) * | 1958-03-17 | 1959-11-02 | Le Ministre De La Defense Nati | New products that can be used as plant growth regulators |
| BE576586A (en) * | 1958-03-17 | 1959-07-01 | France Etat | New chemicals which can be used in particular as regulators of plant growth or as fungicides, their manufacturing processes and their applications. |
| GB949170A (en) * | 1960-03-15 | 1964-02-12 | France Etat | Carbamyl and thiocarbamyl substances, methods for producing same and applications thereof |
| DE3809053A1 (en) * | 1988-03-18 | 1989-09-28 | Bayer Ag | SUBSTITUTED 5-AMINO-4H-1,2,4-TRIAZOL-3-YL-CARBONIC ACID AMIDES, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS HERBICIDES |
-
1989
- 1989-10-25 HU HU895428A patent/HU206095B/en not_active IP Right Cessation
-
1990
- 1990-10-25 KR KR1019900017151A patent/KR910007895A/en not_active Ceased
- 1990-10-25 IL IL9612690A patent/IL96126A/en not_active IP Right Cessation
- 1990-10-25 AT AT90311690T patent/ATE122343T1/en not_active IP Right Cessation
- 1990-10-25 RU SU904831604A patent/RU2039051C1/en active
- 1990-10-25 IN IN851/MAS/90A patent/IN171608B/en unknown
- 1990-10-25 CN CN90108619A patent/CN1051173A/en active Pending
- 1990-10-25 PL PL90287506A patent/PL164879B1/en unknown
- 1990-10-25 YU YU201190A patent/YU47564B/en unknown
- 1990-10-25 BG BG093093A patent/BG51044A3/en unknown
- 1990-10-25 FI FI905254A patent/FI905254A7/en not_active IP Right Cessation
- 1990-10-25 ES ES90311690T patent/ES2076334T3/en not_active Expired - Lifetime
- 1990-10-25 JP JP2288248A patent/JPH03246282A/en active Pending
- 1990-10-25 ZA ZA908557A patent/ZA908557B/en unknown
- 1990-10-25 EP EP90311690A patent/EP0425283B1/en not_active Expired - Lifetime
- 1990-10-25 DE DE69019294T patent/DE69019294T4/en not_active Expired - Lifetime
- 1990-10-25 DE DE69019294A patent/DE69019294D1/en not_active Expired - Fee Related
- 1990-10-25 US US07/604,488 patent/US5225410A/en not_active Expired - Fee Related
- 1990-10-25 DK DK90311690.3T patent/DK0425283T3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2076334T3 (en) | 1995-11-01 |
| IL96126A (en) | 1994-11-11 |
| JPH03246282A (en) | 1991-11-01 |
| US5225410A (en) | 1993-07-06 |
| HU895428D0 (en) | 1990-01-28 |
| YU47564B (en) | 1995-10-03 |
| DE69019294D1 (en) | 1995-06-14 |
| IN171608B (en) | 1992-11-21 |
| PL287506A1 (en) | 1991-08-12 |
| EP0425283A2 (en) | 1991-05-02 |
| KR910007895A (en) | 1991-05-30 |
| FI905254A7 (en) | 1991-04-26 |
| IL96126A0 (en) | 1991-07-18 |
| CN1051173A (en) | 1991-05-08 |
| BG51044A3 (en) | 1993-01-15 |
| ATE122343T1 (en) | 1995-05-15 |
| ZA908557B (en) | 1991-12-24 |
| DE69019294T2 (en) | 1995-09-07 |
| EP0425283A3 (en) | 1991-10-23 |
| FI905254A0 (en) | 1990-10-25 |
| HU206095B (en) | 1992-08-28 |
| EP0425283B1 (en) | 1995-05-10 |
| DE69019294T4 (en) | 1996-01-18 |
| HUT59382A (en) | 1992-05-28 |
| DK0425283T3 (en) | 1995-07-10 |
| PL164879B1 (en) | 1994-10-31 |
| RU2039051C1 (en) | 1995-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP9802323A2 (en) | Pyrimidine derivatives , process for producing them and pharmaceutical compositions containing them | |
| CY1108313T1 (en) | PRODUCTS OF KINOLIN AND USE FOR 5-HT6 PROJECTS | |
| ATE12042T1 (en) | AMINO ACID DERIVATIVES AND THEIR THERAPEUTIC USE. | |
| ES2167676T3 (en) | EPOXI IGNIFUGAS RESINS AND IGNIFUGENT AGENTS FOR EPOXI RESINS. | |
| HUP9701157A2 (en) | Heterocyclic condensed pyridine derivatives, process for producing them, pharmaceutical compositions containing the same | |
| MY102082A (en) | Dihydropyridine derivatives, their production and use | |
| HUT52059A (en) | Process for producing pharmaceutical compositions and new quinoline derivatives as a group of active components | |
| DE3069408D1 (en) | 5-oxo- and 5-thioxoproline derivatives, process for their production and pharmaceutical compositions containing them | |
| AU589427B2 (en) | Pyridonecarboxylic acid derivatives and process for their preparation | |
| HUT41760A (en) | Process for producing xantone derivatives and pharmaceutical compositions containing them | |
| CY1109769T1 (en) | METHOD OF PREPARING NITROXIDE PRODUCERS OF TINAPROXEN | |
| YU201190A (en) | NEW TRIAZOLYLHYDRAZIDE DERIVATIVES AND PROCEDURE FOR THEIR MAKING | |
| SE9000871D0 (en) | DERIVATIVES OF THIENO-TRIAZOLO-DIAZEPINE, A PREPARATION PROCESS OF THE SAME AND THERAPEUTIC COMPOSITIONS CONTAINING THEM | |
| YU47605B (en) | PROCEDURE FOR OBTAINING STYRENE SUBSTITUTED DERIVATIVES | |
| PT79146A (en) | Process for preparing flavene or thioflavene derivatives and pharmaceutical compositions containing them | |
| DE2965701D1 (en) | 1-imidazol-2-ylidene-3-thienyl-urea derivatives, processes therefor, and pharmaceutical compositions | |
| EP0391254A3 (en) | Novel thiouracil derivatives pharmaceutical compositions containing them and process for preparing same | |
| ES8705382A1 (en) | New carbacyclin derivatives, processes for their preparation and compositions containing them. | |
| YU3099A (en) | Novel erythromycine derivatives, procedure for production and application thereof | |
| GB2341861A (en) | Substituted imidazole derivatives and their use as histamine H 3 receptor ligands | |
| EA200400469A1 (en) | SUBSTITUTED DERIVATIVES ALKYLAMINOPIRIDAZINONE, METHOD OF THEIR RECEIVING AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS | |
| ES8702399A1 (en) | 1,5-Benzoxathiepin derivatives, their production and use. | |
| HUP9900642A2 (en) | 2-substituted benzimidazole derivatives as inhibitors of smooth muscle cell proliferation, process for producing them and their use for producing pharmaceutical compositions | |
| CA2093510A1 (en) | Oxysulfonyl carbamates | |
| ES8705392A1 (en) | Dihydroisoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them. |