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WO2025231465A1 - Absorbant de seringue de traitement de greffe de graisse et seringue l'incorporant - Google Patents

Absorbant de seringue de traitement de greffe de graisse et seringue l'incorporant

Info

Publication number
WO2025231465A1
WO2025231465A1 PCT/US2025/027716 US2025027716W WO2025231465A1 WO 2025231465 A1 WO2025231465 A1 WO 2025231465A1 US 2025027716 W US2025027716 W US 2025027716W WO 2025231465 A1 WO2025231465 A1 WO 2025231465A1
Authority
WO
WIPO (PCT)
Prior art keywords
aspirate
syringe
fat cells
withdrawing
barrel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2025/027716
Other languages
English (en)
Inventor
David S. Kirn
William Whitman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orchid Holdings LLC
Original Assignee
Orchid Holdings LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Holdings LLC filed Critical Orchid Holdings LLC
Publication of WO2025231465A1 publication Critical patent/WO2025231465A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details

Definitions

  • the invention generally relates to a syringe for harvesting, processing, and reintroducing a small volume fat graft into patients and, more specifically, to an absorbent for the syringe and methods of using the same.
  • the process of micro fat grafting involves the suction aspiration, e.g. liposuction, of small amounts of fat from a harvest site of a patient, and subsequent re-injection of the fat into a grafting site of the same patient.
  • the aspirate is harvested from an area of the patient in which an excess of fat cells reside, such as the patient’s thighs, abdomen, or hips.
  • the aspirate typically includes fat cells, local anesthetic, oil from ruptured fat cells, and blood.
  • viable fat cells In order to deliver a high- quality fat cell graft, viable fat cells must be gently separated from the other components of the aspirate. Excess or rough processing of the fat cells can damage the viable cells.
  • the goal is to re-introduce or graft as many viable fat cells as possible and minimize the re-introduction of the non-viable cells and other components of the aspirate.
  • the most common micro fat grafting technique involves an initial liposuction of aspirate with a syringe and a harvesting cannula. The surgeon creates a vacuum inside the syringe which draws the aspirate through the cannula and into the barrel of the syringe. Although the aspirate could be directly re-injected into the grafting site, it is preferential to separate the fat cells from the remaining aspirate since only the fat cells are capable of maintaining viability in the grafting site.
  • This syringe 10 is generally shown in Figure 1 and includes a two component barrel 12 having a first portion 14 which is used to harvest an aspirate, including fat cells from a patient, and a second portion 16 which is used to process the aspirate.
  • the first portion 14 is referred to as a proximal portion and the second portion 16 is referred to as a distal portion.
  • a plunger 18 can be withdrawn to generate a vacuum which suctions the aspirate from a harvest site of the patient. Once a desired amount of aspirate has been harvested, the cannula is removed from the patient and detached from the syringe 10 and processing of the fat graft initiated.
  • Processing of the fat graft involves withdrawing the syringe plunger 18 so that the harvested aspirate is drawn into a processing chamber 20, thus exposing the aspirate to an absorbent 22.
  • the absorbent 22 is positioned between a filter 24 and an inner wall of the distal portion 16 of the syringe for absorbing the aspirate passing through the filter.
  • the aspirate includes a fluid portion and a fat cells portion. The fluid portion of the aspirate is drawn through or traverses the filter 24 leaving the fat cells portion for reintroduction.
  • the absorbent 22 in the patented system is generally described as any material capable of retaining fluid, including a cotton, a super absorbent-embedded cotton, a superabsorbent material, or a superabsorbent polymer. Even more, the absorbent 22 is described as a multicomponent absorbent including a first cotton fiber component that wicks and/or absorbs oils from ruptured fat cells. The cotton fibers are combed or straightened fibers that can soak up oil by letting it flow into channel-like spaces that form between the fibers relying on capillary action.
  • a second fiber component includes fibers which wick and/or absorb aqueous fluids such as saline, blood, and local anesthetic, and a third component includes a material, such as a sodium polyacrylate or other superabsorbent material, for trapping or locking in the wicked fluids.
  • the absorbent 22 is positioned within the processing or absorbent chamber 20 defined in part by the distal portion 16 of the barrel 12 as shown in Figure 2.
  • the absorbent components may be situated in layers arranged and varied in either a vertical, a radial, or an angular pattern with respect to a central axis of the syringe 10.
  • a first layer 26 may include the first and second fiber components for wicking oils and aqueous fluids
  • a second layer 28 may include the material for locking in the wicked oil and fluid.
  • the absorbent may also be configured as a cartridge 30 in another embodiment and inserted into the chamber 20 as a unit during manufacture or at the time of use.
  • the cartridge 30 may be stamped or otherwise formed and slid into the chamber around the filter 24.
  • the filter 24 extends within the chamber 20 and adjacent the absorbent 22.
  • the filter 24 is described as a cotton gauze, a mesh filter, a fine mesh filter, a paper, an absorptive paper, a semipermeable membrane, and/or a perforated polymer sheet.
  • Kirn further describes the filter 24 (shown in Figure 5) as being generally cylindrical in shape and forming a portion of a filter assembly 32.
  • the filter 24 is an eighty mesh screen.
  • the filter 24 may be a plastic polymer or metal and may utilize a broader range of mesh so long as the size of the openings are sufficient to limit, if not prevent, fat cells from traversing the filter.
  • the filter 24 forms a portion of the filter assembly 32.
  • a first or proximal support 34 receives a first end of the filter 24, engages the syringe, as shown herein in Figure 1, to preclude (1) longitudinal and lateral movement of its proximal end and (2) aspirate drawn into the channel from entering the absorptive chamber 20 except through the filter 24.
  • a second support 36 receives a second end of the filter 24, engages the syringe limiting lateral movement of the filter, defines a ledge 38 supporting a gasket or firing 40, and engages a cap 42 trapping the sealing gasket 40 in position therebetween for preventing leakage along the plunger 18.
  • a syringe for withdrawing an aspirate including fat cells from a body.
  • the syringe may be broadly described as including a barrel having an inner wall, a filter for separating the fat cells from the aspirate extends within the barrel, an absorbent positioned between the filter and the barrel inner wall for absorbing aspirate that traversed the filter, and a plunger for longitudinal movement within the barrel, the plunger having a gasket attached to a proximal end of the plunger, wherein the absorbent includes fibers and a majority of the fibers are oriented in a substantially radial direction relative a central axis of the barrel.
  • the absorbent includes a plurality of fabric annular discs.
  • the plurality of annular discs are substantially concentrically stacked.
  • each of the plurality of annular discs includes a central aperture defined by an inner ring and the majority of the fibers oriented in a substantially radial direction extending from the inner ring.
  • the filter is a mesh screen.
  • the mesh screen is a made of stainless-steel.
  • the mesh screen includes a plurality of apertures selected to generally be between 60 - 100 mesh.
  • the mesh screen is at least partially coated.
  • the mesh screen is at least partially coated with a hydrophilic material to encourage flow of an aqueous component of the fluid component of the aspirate.
  • the mesh screen is at least partially coated with a lipophilic material to encourage flow of an oil component of the fluid component of the aspirate.
  • the mesh screen is partially coated with a hydrophilic material to encourage flow of an aqueous component of the fluid component of the aspirate and partially coated with a lipophilic material to encourage flow of an oil component of the fluid component of the aspirate.
  • the mesh screen includes a flared end.
  • the syringe further includes a projection extending from the barrel first portion for engaging the flared end.
  • the syringe further includes a guide supported by the barrel first portion for engaging the flared end.
  • the barrel includes first and second portions and an inner diameter of an inner wall of the barrel first portion is substantially the same as an inner diameter of an inner wall of the filter.
  • the barrel first portion has an inner wall with a lesser inner diameter than an inner diameter of an inner wall of the barrel second portion.
  • the inner wall of the barrel second portion and the filter define an absorbing chamber wherein the filter resides.
  • the inner wall of the first portion defines a notch for receiving a proximal end of the filter.
  • the syringe further includes a ring that encases an end of the mesh screen.
  • the notch receives the ring.
  • the ring sealingly engages at least the notch.
  • the absorbent is a sheet of fabric folded back and forth in an accordion style.
  • the folded sheet forms a substantially cylindrical shape.
  • the cylindrically shaped folded sheet includes a first group of folded edges adjacent the filter and a second group of folded edges adjacent the barrel inner wall.
  • at least one slit is formed in at least one of the folded edges of the first group of folded edges.
  • the filter is a mesh screen.
  • the mesh screen is a made of stainless-steel.
  • the mesh screen includes a plurality of apertures selected to generally be between 60 - 100 mesh.
  • the absorbent includes an absorbent layer positioned between fabric sheets.
  • the absorbent layer is a fabric or a weave of fibers.
  • a first of the fabric sheets is adjacent the filter and a second of the fabric sheets is adjacent the barrel inner wall.
  • the plunger gasket includes a chamfer formed on a distal portion of the gasket.
  • a syringe for withdrawing an aspirate including fat cells from a body.
  • the syringe may be broadly described as including a barrel having an inner wall, a mesh screen filter for separating the fat cells from the aspirate extends within the barrel, an absorbent positioned between the filter and the barrel inner wall for absorbing aspirate that traversed the filter, and a plunger for longitudinal movement within the barrel, the plunger having a gasket attached to a proximal end of the plunger, wherein the absorbent includes a plurality of stacked fabric annular discs.
  • each of the fabric annular discs of the plurality of stacked fabric annular discs includes a central aperture defined by an inner ring and a majority of the fibers in the fabric annular discs is oriented in a substantially radial direction extending from the inner ring.
  • a syringe for withdrawing an aspirate including fat cells from a body.
  • the syringe may be broadly described as including a barrel having an inner wall, a mesh screen filter for separating the fat cells from the aspirate extends within the barrel, an absorbent positioned between the filter and the barrel inner wall for absorbing aspirate that traversed the filter, and a plunger for longitudinal movement within the barrel, the plunger having a gasket attached to a proximal end of the plunger, wherein the absorbent includes a sheet of fabric folded back and forth in an accordion style.
  • the cylindrically folded sheet includes a first group of folded edges substantially adjacent to the mesh screen filter.
  • At least one slit is formed in at least one of the first group of folded edges.
  • a syringe for withdrawing an aspirate including fat cells from a body.
  • the syringe may be broadly described as including a barrel having first and second portions, the first portion having an inner wall having an diameter less than an inner diameter of an inner wall of the second portion, a mesh screen having an inner diameter substantially the same as the inner diameter of the inner wall of the first portion of the barrel extends within the barrel, a plunger for longitudinal movement within the barrel, the plunger having a gasket attached to a proximal end forming a seal with an inner wall of the mesh screen and the inner wall of the barrel first portion, and an absorbent including fibers and at least partially contacting the mesh screen for drawing a fluid portion of the aspirate through the mesh screen in a substantially radial direction relative a direction of longitudinal movement of the plunger.
  • a syringe for withdrawing an aspirate including fat cells from a body.
  • the syringe may be broadly described as including a barrel having an inner wall, a mesh screen sized to prevent fat cells from traversing the mesh screen extends within the barrel, an absorbent positioned between the mesh screen and the barrel inner wall for absorbing aspirate that traversed the mesh screen, and a plunger for longitudinal movement within the barrel, wherein the absorbent includes a stack of discs to draw the aspirate that traversed the mesh screen in a substantially radial direction relative a direction of longitudinal movement of the plunger.
  • a method of securing fat cells for fat grafting using a syringe includes the steps of retracting a plunger from a first position to a second position in order to draw an aspirate from a harvest site of a body into a barrel of the syringe, further retracting the plunger from the second position in order to draw a wash solution into the barrel of the syringe, exposing the combined aspirate and wash solution to an absorbent including a plurality of stacked annular discs for absorbing a fluid portion of the aspirate, moving the plunger toward the first position such that a remaining portion of the aspirate is no longer exposed to the absorbent, and repeating the exposing and moving steps.
  • the plurality of stacked annular discs are substantially concentrically stacked.
  • each of the plurality of stacked annular discs includes a central aperture defined by an inner ring and the majority of the fibers oriented in a substantially radial direction extending from the inner ring.
  • the filter is a mesh screen.
  • the absorbent is a sheet of fabric folded back and forth in an accordion style.
  • the folded sheet forms a substantially cylindrical shape.
  • the cylindrically shaped folded sheet includes a first group of folded edges adjacent the filter and a second group of folded edges adjacent the barrel inner wall.
  • At least one slit is formed in at least one of the folded edges of the first group of folded edges.
  • the absorbent includes an absorbent layer positioned between fabric sheets.
  • the absorbent layer is a fabric or a weave of fibers.
  • a first of the fabric sheets is adjacent the filter and a second of the fabric sheets is adjacent the barrel inner wall.
  • the further retracting step includes retracting the plunger to a third position and the exposing step includes further retracting the plunger from the third position where the combined aspirate and wash solution are exposed to the absorbent.
  • the syringe includes a filter and the absorbent is supported between the filter and a first portion of an inner wall of the barrel.
  • the a gasket is supported at an end of the plunger and sealing engages a second portion of the inner wall of the barrel and engages an inner wall of the filter.
  • the plunger gasket includes a chamfer formed on a distal portion of the gasket.
  • the plunger gasket dislodges any unabsorbed aspirate during the step of moving the plunger toward the first position such that a remaining portion of the aspirate is no longer exposed to the absorbent.
  • Figure 1 is a perspective view of a prior art syringe for withdrawing aspirate from a body for micro fat grafting with a partially transparent barrel;
  • Figure 2 is a section cut end view of the prior art syringe and a multi-component absorbent;
  • Figure 3 is a section cut end view of the prior art syringe with the multi-component absorbent formed in layers;
  • Figure 4 is a section cut end view of another embodiment of the prior art syringe wherein the absorbent is formed into a cartridge;
  • Figure 5 is a perspective view of a filter assembly used with the prior art syringe
  • Figure 6 is a section cut partial plan view of an absorbent disc illustrating a direction of fibers therein;
  • Figure 7 is a section cut plan view of a portion of the syringe showing a plunger withdrawn into the distal end adjacent an absorbent for aspirate processing;
  • Figure 8 is perspective view of an absorbent disc used in one embodiment to form the absorbent shown in Figures 6 and 7;
  • Figure 9 is a perspective view of another embodiment of an absorbent
  • Figure 10 is a top view of the other embodiment of the absorbent showing an accordion or folding style used to form the absorbent.
  • Figure 11 is an yet another embodiment of an absorbent including an absorbent layer sandwiched between fabric layers and indicating orientation of fibers within the absorbent layer;
  • Figure 12 is a section cut plan view of a portion of the syringe showing an interface between the mesh screen and the proximal portion of the syringe and a chamfered plunger gasket for assisting with the transition between the proximal and distal portions of the syringe;
  • Figure 13 is a section cut plan view of a portion of the syringe showing an interface between the mesh screen and the proximal portion of the syringe wherein an end portion of the mesh screen is flared outward and engages a projection extending from the proximal portion.
  • a syringe 50 for withdrawing an aspirate including fat cells from a body for micro fat grafting uses a mesh screen filter 52 and absorbent material 54 in combination to separate and contain an unwanted fluid portion of an aspirate from a desired fat cells portion. In doing so, a high quality fat graft can be obtained in a closed system in an expedited manner. In order to achieve such an expedited process, one or more features (e.g., the type, quality, quantity, and positioning) of the absorbent material or absorbent 54 within the syringe 50 should be carefully considered.
  • the absorbent 54 should provide enough fluid capacity to remove most, if not all, of the unwanted or remaining fluid portion of the aspirate drawn into a processing chamber 48 and hinder the absorbed remaining fluid portion from reentering the processing chamber during the micro fat grafting process.
  • a plurality of absorbent discs 56 are stacked atop one another and, collectively, form the absorbent 54.
  • An exemplary absorbent disc 56 is shown in Figure 7 and a horizontal orientation of fibers 58 within an absorbent disk is illustrated in Figure 8.
  • the horizontal fibers 58 generally extend radially from a cut surface 60 which forms an inner ring of the disc 56.
  • the remaining fluid is drawn through the mesh screen 52 and into the absorbent 54.
  • the horizontal alignment of the fibers 58 allows the remaining fluid to traverse radially from a first end adjacent the cut surface 60 and mesh screen 52 toward a second end adjacent an inner wall 62 of the syringe 50.
  • the orientation of fibers which at least partially make up the absorbent 54 must be considered. If a majority of the fibers in an absorbent are oriented in a vertical position when viewing a syringe from top to bottom, then absorption will mainly occur in that same direction at the expense of absorption in a radial direction. In other words, radial penetration into the absorbent will be limited. For this reason, it is desirable to have a majority of the fibers within the absorbent 54 oriented in a substantially radial direction relative a central axis of the barrel and plunger of the syringe.
  • FIG. 6 illustrates a plurality of absorbent discs 60 stacked atop one another to form an absorbent 54.
  • the utilization of stacked discs 60 ensures at least a portion of fibers 58 in each disc is oriented in a radial direction.
  • the number of fibers 58 oriented in a radial direction within an absorbent 54 can be further improved by weaving of the fibers during the production process.
  • an absorbing chamber 64 is partially defined by the mesh screen filter 52 and an inner wall 62 of the syringe 50 as shown in Figure 6.
  • an absorbent 66 includes an absorbent fabric sheet 68 that is folded back and forth in an accordion style (similar to the fabric within an oil filter). This approach, again, orients at least a majority of fibers within the sheet 68 in a radial direction. As shown in Figure 10, the remaining fluid portion drawn through the mesh screen filter 52 is drawn radially from an inner folded edge 70 of the absorbent 66 adjacent the mesh screen filter toward an outer folded edge 72 adjacent the syringe inner wall 62. In other embodiments, one or more slits 74 may be made along the inner folded edges or ends 70 of the absorbent 66 as shown in Figure 9.
  • the one or more slits 74 may be made in one or more of the inner folded edges 70 to allow for the remaining fluid portion of aspirate to improve contact with the absorbent fibers and may extend partially along or along a majority of a length of the inner folded edges 70.
  • an absorbent can be made utilizing known techniques to mechanically weave or blow fibers into a mold that is shaped to conform to an absorbing chamber such as chamber 64. This approach results in an absorbent having fibers oriented in a substantially radial direction without the need for mechanical cutting or manipulation.
  • absorbents made from a non-woven material still benefit from the above-described design processes. While such absorbents may be non-woven and have seemingly random placement of fibers therein, the sheet design of such absorbents dictates that the average orientation of the fibers remains parallel to a face of the fabric. This is due at least in part to the length of each fiber being longer than a thickness of the fabric sheet. In this way, a fiber cannot have its full length perpendicular to the face and must have some portion nonperpendicular, i.e., radially extending. The same cannot be said for the parallel direction as a fiber’s entire length can be oriented in this direction.
  • the absorbent 76 includes a “sandwich” construction in which an absorbent fabric or weave of fibers forms an absorbent layer 78 positioned between fabric sheets 80.
  • the outer fabric sheets 80 have sufficient mechanical strength to support the absorbent layer 78. This allows the absorbent layer 78 to be formed using a less sturdy or mechanically strong absorbent material while allowing the absorbent to be manufactured in an desired configuration.
  • arrowed lines, designated reference numeral 82 and overlaying the absorbent layer 78 indicate an orientation of the fibers within the absorbent layer as being substantially radially extending.
  • a mesh screen filter is used in the described embodiments to separate the fat cells portion from the remaining fluid portion of the absorbent.
  • the mesh screen filter 52 confines the absorbent 54 and also allows for a plunger 84 to effectively and efficiently move the fat cells portion, including the viable fat cells, from the processing chamber 48 of the syringe 50 once sufficient absorption of the remaining fluid component has been achieved.
  • a stainless-steel mesh screen filter 52 is used due to its rigidity and biocompatibility while a plastic or composite mesh screen filter may be used in other embodiments.
  • the hole sizing of the mesh screen filter 52 is selected to generally be between 60 - 100 mesh which range is selected as optimal.
  • mesh sizing indicates a number of openings in a mesh screen per linear inch.
  • the lower limit on the mesh sizing is important because too small a sizing does not allow for enough of the remaining fluid portion (e.g., medical fluids and oils) to pass through the mesh screen in a desired amount of time leading to a graft of decreased quality.
  • the larger limit on the mesh size relates to the potential loss of viable fat cells during the processing stage.
  • the above-described arrangement between the plunger gasket 86 and the mesh screen filter 52 can result in certain challenges. For example, as the plunger gasket 86 moves longitudinally within the processing chamber 48, strands of wire can be exposed at a point where the mesh screen filter 52 is terminated. Such exposed strands of wire can puncture, snag, or otherwise damage the plunger gasket 86 as it moves within and through the processing chamber 48. Doing so can cause the plunger gasket 86 to dislodge from the plunger 84, cause the mesh screen filter 52 to be pulled back and collapse, or create a hole in the plunger gasket rendering it inoperable due to no longer being sealable against filter 52 and/or the proximal portion of the syringe 50.
  • an end of the mesh screen filter 52 may be encased in a ring 88 as partially shown in Figure 12. This can be achieved, for example, either by molding a plastic (or other known moldable materials) ring 88 over the mesh screen filter 52 or gluing such a ring onto the mesh screen filter. In this way, the plunger gasket 86 can move safely past the interface with minimal danger of damage.
  • the mesh screen filter 52 may be integrally molded into the syringe 50 to achieve the same result.
  • a mesh screen filter 90 is configured with an outwardly flared proximal end 92.
  • the flared proximal end 92 engages a guide 94 correspondingly flared for engaging and directing the flared proximal end toward a resting position.
  • the flared proximal end 92 is supported by a projection 96 extending from the proximal portion 98 of the syringe. In this manner, smooth passage of the plunger gasket (not shown) is ensured without the need for a ring or molding.
  • the plunger gasket 86 may be formed with a chamfer 100 on a distal portion 102.
  • Standard plunger gaskets do not include a chamfer and can be more difficult to move backwards against a non-uniform surface.
  • the chamfer 100 may be integrally molded into the plunger gasket 86 and can take the shape of a chamfer, a filet, or a combination thereof, or a similarly angled shape.
  • a harvesting device such as a cannula
  • a cannula is connected to the syringe 50 by means of a Luer lock fitting, or other fitting, extending from the syringe as is known in the art.
  • the cannula is inserted into the body; the user withdraws the plunger 84 of the syringe 50 creating a vacuum pressure in the syringe and moves the cannula in a manner familiar to those skilled in the art.
  • the vacuum pressure draws an aspirate into a harvest chamber 104 of the syringe 50.
  • the user further withdraws the plunger 84 to maintain a consistent, low vacuum.
  • Graduations printed on the syringe 50 reveal an amount of aspirate collected. This process continues until a desired quantity of aspirate has been harvested or the harvesting chamber 104 is substantially full.
  • the cannula is subsequently removed from the patient’s body and detached from the syringe 50, and processing of the fat graft
  • the user may then connect the syringe 50 to an external wash solution source (not shown).
  • the wash solution source is connected to the syringe 50 by means of the above-described Luer lock fitting in order to preserve a sterile environment provided by the closed system.
  • the user may further retracts the plunger 84 drawing a wash solution into the harvesting chamber 104 of the syringe 50.
  • the aspirate and the wash solution are combined in the harvest chamber 104 and then drawn, via further movement of the plunger 84, into the processing chamber 48.
  • the syringe 50 may be agitated by rolling, rotating, and/or shaking for a period of time. In the described embodiment, a period of one minute is deemed sufficient although any period of time may be utilized albeit with varying effectiveness.
  • the aspirate including any of the remaining fluid portion and the fat cells portion remaining in the processing chamber 48, is then returned to the harvest chamber 104 and a second specified quantity (e.g., again about 25% of the initial aspirate) of a wash solution is added using the plunger 84.
  • a second specified quantity e.g., again about 25% of the initial aspirate
  • the step of returning unabsorbed aspirate to the harvest chamber 104 provides an added benefit of wiping the mesh screen filter 52 with the plunger gasket 86 and minimizing any obstruction within the mesh screen filter.
  • physical contact between the plunger gasket 86 and the inner wall of the mesh screen filter 52 during the step of moving the plunger 84 proximally within the syringe 50 dislodges or breaks away any non-liquid components of the unabsorbed aspirate from the mesh screen filter.
  • the user moves the plunger 84 proximally within the syringe thereby pushing the fat cells component into the harvest chamber 104 expelling any remaining air.
  • the same cannula used for harvesting the aspirate, a different one, a hypodermic needle, or other re-insertion device may then be reattached to the fitting.
  • the re-insertion device is inserted into the patient’s body at the graft site.
  • the plunger 84 is then pushed further forward expelling the processed fat graft from the harvest chamber 104, through the cannula, and into the patient’s body.
  • the processed graft may be pushed out into another container, or syringe(s), in an open or a closed transfer process.
  • the described syringes are intended for discard after a single use.
  • the mesh screen filter 52 may be coated with various coatings to decrease surface tension and encourage flow of the remaining fluid portion of the aspirate across the mesh screen.
  • the mesh screen filter 52 may be partially coated with one or more of the abovereferenced materials.
  • one half of the mesh screen filter may be coated with a hydrophilic material to encourage flow of an aqueous component of the remaining fluid portion, and the other half could be coated with a lipophilic material to encourage flow of an oil component of the remaining fluid portion. All such modifications and variations are within the scope of the appended claims when interpreted in accordance with the breadth to which they are fairly, legally and equitably entitled.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

Une seringue pour retirer un aspirat comprenant des cellules de graisse d'un corps comprend un cylindre ayant une paroi interne, un filtre pour séparer les cellules de graisse de l'aspirat s'étend à l'intérieur du cylindre, un absorbant positionné entre le filtre et la paroi interne de cylindre pour absorber l'aspirat qui a traversé le filtre, et un piston pour un mouvement longitudinal à l'intérieur du cylindre. Le piston comprend un joint d'étanchéité fixé à une extrémité proximale et l'absorbant comprend des fibres et une majorité des fibres sont orientées dans une direction sensiblement radiale par rapport à une direction de déplacement longitudinal du piston.
PCT/US2025/027716 2024-05-03 2025-05-05 Absorbant de seringue de traitement de greffe de graisse et seringue l'incorporant Pending WO2025231465A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202463642214P 2024-05-03 2024-05-03
US63/642,214 2024-05-03

Publications (1)

Publication Number Publication Date
WO2025231465A1 true WO2025231465A1 (fr) 2025-11-06

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2025/027716 Pending WO2025231465A1 (fr) 2024-05-03 2025-05-05 Absorbant de seringue de traitement de greffe de graisse et seringue l'incorporant

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US20190328977A1 (en) * 2016-12-12 2019-10-31 Werd, Llc A syringe for processing fat grafts and related methods
WO2023225310A1 (fr) * 2022-05-20 2023-11-23 Orchid Holdings Llc Seringue pour traiter les greffes de graisse et procédés associés

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US20170066171A1 (en) * 2010-07-16 2017-03-09 Sio2 Medical Products, Inc. Injection molding processes for molding barrel and thermoplastic syringes having low axial draft angles
US20180304008A1 (en) * 2015-10-14 2018-10-25 Amogreentech Co., Ltd. Liquid drug-filtering filter medium, method for producing same, and liquid drug-filtering filter module comprising same
US20190328977A1 (en) * 2016-12-12 2019-10-31 Werd, Llc A syringe for processing fat grafts and related methods
CN207237047U (zh) * 2017-02-24 2018-04-17 陈晓琳 一次性便捷无菌注射器
WO2023225310A1 (fr) * 2022-05-20 2023-11-23 Orchid Holdings Llc Seringue pour traiter les greffes de graisse et procédés associés

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