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WO2025226810A1 - Dispositifs d'entraînement de dispositif d'injection et de transfert - Google Patents

Dispositifs d'entraînement de dispositif d'injection et de transfert

Info

Publication number
WO2025226810A1
WO2025226810A1 PCT/US2025/025957 US2025025957W WO2025226810A1 WO 2025226810 A1 WO2025226810 A1 WO 2025226810A1 US 2025025957 W US2025025957 W US 2025025957W WO 2025226810 A1 WO2025226810 A1 WO 2025226810A1
Authority
WO
WIPO (PCT)
Prior art keywords
rotor
injection device
winding
transfer device
gear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2025/025957
Other languages
English (en)
Inventor
Rowan Joseph CONVERSE
Kory Gunnerson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enable Injections Inc
Original Assignee
Enable Injections Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enable Injections Inc filed Critical Enable Injections Inc
Publication of WO2025226810A1 publication Critical patent/WO2025226810A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps

Definitions

  • the present subject matter relates generally to on-body injection devices and transfer devices for transferring medication from vials to on-body injection devices and, in particular to reusable training devices or reusable trainers for instructing users on the proper use of such injection and transfer devices.
  • Injection devices that are worn by a patient temporarily or for extended periods (on-body injection devices) are well known in the medical field. Transfer devices are often used to transfer liquid medication from vials to such on-body injection devices prior to placement on a patient.
  • a transfer device trainer mechanism includes a vial elevator including a camming hook and a vial elevator shaft within which the vial elevator moves between an extended position and a retracted position.
  • a cam ring is rotatably positioned around the vial elevator and includes a camming surface configured to be traversed by the camming hook as the vial elevator moves from the extended position to the retracted position whereby the cam ring rotates in a cam ring actuation direction.
  • the cam ring also includes a belt gripping surface.
  • a winding assembly includes a center timing shaft featuring a winding sheave, a clock spring having an inner end connected to the center timing shaft and an outer end, a winding hub connected to the outer end of the clock spring, where the winding hub includes a transfer device winding fitting, and a damper gear secured to the winding hub.
  • a transfer device damper operatively engages the damper gear.
  • a drive belt engages the belt gripping surface of the cam ring and the winding sheave of the center timing shaft so that when the cam ring rotates, the center timing shaft rotates.
  • a winding assembly in another aspect, includes a center timing shaft featuring a winding sheave, a clock spring having an inner end connected to the center timing shaft and an outer end, a winding hub connected to the outer end of the clock spring, where the winding hub includes a transfer device winding fitting, and a damper gear secured to the winding hub.
  • a reusable transfer device trainer in another aspect, includes a transfer device housing including an injection device mounting surface.
  • a vial elevator is positioned within the transfer device housing and receives a vial.
  • the vial elevator includes a camming hook.
  • the vial elevator moves between an extended position and a retracted position within a vial elevator shaft.
  • a cam ring is rotatably positioned around the vial elevator and includes a camming surface configured to be traversed by the camming hook as the vial elevator moves from the extended position to the retracted position whereby the cam ring rotates in a cam ring actuation direction.
  • the cam ring also includes a belt gripping surface.
  • a winding assembly also includes a center timing shaft featuring a timing shaft recess having a timing shaft post positioned therein and a winding sheave.
  • a clock spring assembly includes a clock spring positioned within a clock spring collar. The clock spring has an outer end attached to the clock spring collar and an inner end.
  • a winding hub includes a transfer device winding fitting and a skirt portion defining a winding hub recess.
  • the injection device mounting surface includes a mounting surface opening corresponding to the transfer device winding fitting.
  • the clock spring collar is positioned within the winding hub recess and is secured to the winding hub skirt portion with the winding hub skirt portion positioned within the timing shaft recess with the inner end of the clock spring connected to the timing shaft post.
  • a damper gear is secured to the winding hub.
  • a transfer device damper is operatively connected to the damper gear.
  • a drive belt engages the belt gripping surface of the cam ring and the winding sheave of the center timing shaft so that when the cam
  • a mechanism for simulating an injection includes a push button spring urging the push button towards the raised position.
  • a button claw includes a first flex arm and a second flex arm that move with the push button between the raised and lowered positions.
  • the first flex arm includes a first locking tab and the second flex arm includes a second locking tab.
  • a rotor is rotatably mounted within the injection device housing and is movable between a first rotor position and a second rotor position.
  • the rotor includes a first undercut, a second undercut and a rotor gear having rotor gear teeth.
  • a rotor spring urges the rotor towards the second rotor position.
  • a ratchet gear has a central opening and at least one ratchet tab extending into the central opening.
  • the rotor gear is positioned within the central opening of the ratchet gear with the rotor gear teeth engaging the at least one ratchet tab so that the rotor gear may rotate only in a direction against the urging of the rotor spring with respect to the ratchet gear.
  • a latch is configured to releasably engage the ratchet gear so as to prevent rotation of the ratchet gear.
  • the first and second undercuts of the rotor are engaged by the first and second locking tabs of the flex arms against the urging of the push button spring when the push button is moved from the raised position to the lowered position and the rotor is in the first rotor position.
  • the first and second undercuts release the first and second locking tabs of the flex arms when the rotor is rotated into the second rotor position so that the push button is moved into the raised position by the push button spring.
  • An injection device damper operatively engages the rotor gear teeth.
  • a winding shaft is connected to the rotor so that the rotor turns with the winding shaft.
  • An injection device winding fitting is connected to the winding shaft.
  • the injection device housing includes an injection device winding fitting opening corresponding to the injection device winding fitting.
  • a reusable injection device trainer in another aspect, includes an injection device housing.
  • a push button is mounted within the injection device housing and movable between a raised position and a lowered position.
  • a push button spring urges the push button towards the raised position.
  • a button claw includes a first flex arm and a second flex arm configured to move with the push button between the raised and lowered positions.
  • the first flex arm includes a first locking tab and said second flex arm includes a second locking tab.
  • a rotor is rotatably mounted within the injection device housing and movable between a first rotor position and a second rotor position.
  • the rotor includes a first undercut, a second undercut and a rotor gear having rotor gear teeth.
  • a rotor spring urges the rotor towards the second rotor position.
  • a ratchet gear has a central opening and at least one ratchet tab extending into the central opening.
  • the rotor gear is positioned within the central opening of the ratchet gear with the rotor gear teeth engaging the at least one ratchet tab so that the rotor gear may rotate only in a direction against the urging of the rotor spring with respect to the ratchet gear.
  • a latch is positioned within the housing and releasably engages the ratchet gear so as to prevent rotation of the ratchet gear.
  • the first and second undercuts of the rotor are engaged by the first and second locking tabs of the flex arms against the urging of the push button spring when the push button is moved from the raised position to the lowered position and the rotor is in the first rotor position.
  • the first and second undercuts release the first and second locking tabs of the flex arms when the rotor is moved into the second rotor position so that the push button is moved into the raised position by the push button spring.
  • An injection device damper operatively engaging the rotor gear teeth.
  • a winding shaft is connected to the rotor so that the rotor turns with the winding shaft.
  • An injection device winding fitting is connected to the winding shaft and the injection device housing includes an injection device winding fitting opening corresponding to the injection device winding fitting.
  • a transfer device and injection device training system features a transfer device trainer including a transfer device housing including an injection device mounting surface.
  • a vial elevator is positioned within the transfer device housing and receives a vial.
  • the vial elevator includes a camming hook.
  • the vial elevator moves between an extended position and a retracted position within a vial elevator shaft.
  • a cam ring is rotatably positioned around the vial elevator and includes a camming surface configured to be traversed by the camming hook as the vial elevator moves from the extended position to the retracted position whereby the cam ring rotates in a cam ring actuation direction.
  • the cam ring also includes a belt gripping surface.
  • a winding assembly also includes a center timing shaft featuring a timing shaft recess having a timing shaft post positioned therein and a winding sheave.
  • a clock spring assembly includes a clock spring positioned within a clock spring collar. The clock spring has an outer end attached to the clock spring collar and an inner end.
  • a winding hub includes a transfer device winding fitting and a skirt portion defining a winding hub recess.
  • the injection device mounting surface includes a mounting surface opening corresponding to the transfer device winding fitting.
  • the clock spring collar is positioned within the winding hub recess and is secured to the winding hub skirt portion with the winding hub skirt portion positioned within the timing shaft recess with the inner end of the clock spring connected to the timing shaft post.
  • a damper gear is secured to the winding hub.
  • a transfer device damper is operatively connected to the damper gear.
  • a drive belt engages the belt gripping surface of the cam ring and the winding sheave of the center timing shaft so that when the cam ring rotates, the center timing shaft rotates.
  • An injection device trainer is positioned on the injection device mounting surface of the transfer device trainer.
  • the injection device trainer includes an injection device housing.
  • a push button is mounted within the injection device housing and movable between a raised position and a lowered position.
  • a push button spring urges the push button towards the raised position.
  • a button claw includes a first flex arm and a second flex arm configured to move with the push button between the raised and lowered positions.
  • the first flex arm includes a first locking tab and said second flex arm includes a second locking tab.
  • a rotor is rotatably mounted within the injection device housing and movable between a first rotor position and a second rotor position.
  • the rotor includes a first undercut, a second undercut and a rotor gear having rotor gear teeth.
  • a rotor spring urges the rotor towards the second rotor position.
  • a ratchet gear has a central opening and at least one ratchet tab extending into the central opening. The rotor gear is positioned within the central opening of the ratchet gear with the rotor gear teeth engaging the at least one ratchet tab so that the rotor gear may rotate only in a direction against the urging of the rotor spring with respect to the ratchet gear.
  • a latch is positioned within the housing and releasably engages the ratchet gear so as to prevent rotation of the ratchet gear.
  • the first and second undercuts of the rotor are engaged by the first and second locking tabs of the flex arms against the urging of the push button spring when the push button is moved from the raised position to the lowered position and the rotor is in the first rotor position.
  • the first and second undercuts release the first and second locking tabs of the flex arms when the rotor is moved into the second rotor position so that the push button is moved into the raised position by the push button spring.
  • An injection device damper operatively engaging the rotor gear teeth.
  • a winding shaft is connected to the rotor so that the rotor turns with the winding shaft.
  • An injection device winding fitting is connected to the winding shaft and the injection device housing includes an injection device winding fitting opening corresponding to the injection device winding fitting. The injection device winding fitting engages the transfer device winding fitting.
  • Fig. 1 is a perspective view of an embodiment of the injection device trainer of the disclosure.
  • Fig. 2 is a second perspective view of the injection device trainer of Fig. 1.
  • FIG. 3 is an exploded perspective view of the injection device trainer of Figs. 1 and 2.
  • Fig. 4 is an enlarged exploded view of the vial elevator, vial elevator shaft and cam ring of the injection trainer device of Fig. 3.
  • FIG. 5 is an enlarged second perspective view of the vial elevator shaft of Fig. 4.
  • Fig. 6 is an enlarged second perspective view of the vial elevator of Fig. 4.
  • Fig. 7 is an enlarged perspective view of the elevator locking mechanism of Fig. 3.
  • Fig. 8 is an enlarged perspective view of a first locking shuttle of the elevator locking mechanism of Fig. 7.
  • Fig. 9 is an enlarged perspective view of a second locking shuttle of the elevator locking mechanism of Fig. 7.
  • Fig. 10 is an enlarged perspective view of the shuttle guides and elevator shaft base of Fig. 3.
  • Fig. 11 A is a perspective view of a reset tool for unlocking the elevator locking mechanism of Fig. 7.
  • Fig. 11 B is a perspective view of a base for packaging that includes a reset tool for unlocking the elevator locking mechanism of Fig. 7.
  • Fig. 12 is a bottom perspective view of the transfer device of Figs. 1 and 2 with the housing base removed showing use of the reset tool of Fig. 11 A being used to unlock the elevator locking mechanism of Fig. 7.
  • Fig. 13 is a bottom perspective view of the transfer device of Figs. 1 and 2 with the housing base removed.
  • Fig. 14 is a top perspective view of the transfer device of Figs. 1 and 2 with the top portion of the housing removed.
  • Fig. 15 is an enlarged exploded top perspective view of the winding assembly of the transfer device of Fig. 14.
  • Fig. 16 is an enlarged exploded bottom perspective view of the center timing shaft, the clock spring assembly and the winding hub of the winding assembly of the transfer device of Figs. 14 and 15.
  • Fig. 17 is a bottom perspective view of the transfer device of Figs. 1 and 2 with the housing shown as transparent with an injection device trainer positioned thereon.
  • Fig. 18 is an enlarged perspective view of the latch release cam of Fig.
  • Fig. 19 is a perspective view of the injection device retainer strap of
  • Fig. 20 is a top perspective view of an additional embodiment of the transfer device trainer of the disclosure with the top portion of the housing removed.
  • Fig. 21 is a top perspective view of the transfer device trainer of Fig. 20 with the single component winding hub and damper gear removed.
  • Fig. 22A is an enlarged perspective view of the spring pin assembly of the transfer device trainer of Figs. 20 and 21 .
  • Fig. 22B is a perspective view of the spring pin of Fig. 22A.
  • Fig. 23 is a bottom perspective view of the single component winding hub and damper gear of the transfer device trainer of Fig. 20.
  • Fig. 24 is a top perspective view of the transfer device of Figs. 1 and 2 with an injection device trainer positioned thereon.
  • Fig. 25 is a bottom perspective view of an embodiment of the injection device trainer of the disclosure.
  • Fig. 26 is an exploded perspective view of the injection device trainer of Figs. 25 and 26.
  • Fig. 27 is a bottom perspective view of the upper portion of the housing of the injection device trainer of Figs. 25 and 26.
  • Fig. 28 is a perspective view of the rotor, ratchet gear, push button claw, push button compression spring and winding shaft of the injection device trainer of Figs. 25 and 26.
  • Fig. 29 is a top perspective view of the injection device trainer of Figs. 25 and 26 with the top portion of the housing removed.
  • Fig. 30 is a second top perspective view of the injection device trainer of Fig. 29.
  • Fig. 31 is a bottom view of the rotor of Figs. 29 and 30.
  • Fig. 32 is a top perspective view of the ratchet gear, damper and bottom portion of the housing of the injection device trainer of Figs. 29 and 30.
  • Fig. 33 is a top perspective view of the rotor and push button claw of Figs. 28-30.
  • Fig. 34 is a top perspective view of an alternative embodiment of the injection device trainer of the disclosure.
  • Fig. 35 is an exploded view of the housing bottom portion, rotor, tissue tent bridge and tissue tent injection needle cover of the injection device trainer of Fig. 34.
  • Fig. 36 is a bottom perspective view of the components of Fig. 35 after assembly.
  • Fig. 37 is a bottom perspective view of the rotor of Figs. 35 and 36.
  • Fig. 38 is a top perspective view of the rotor of Fig. 37.
  • Fig. 39 is a top perspective view of the bottom portion of the housing with the assembled rotor and tissue tent bridge of Figs. 35 and 36 and a fill indicator ring installed.
  • Fig. 40 is a top perspective view of the assembled components of Fig. 39 with a ratchet gear also installed.
  • Fig. 41 is a top perspective view of a transfer device trainer that is compatible with the injection device trainer of Figs. 34-40.
  • Fig. 42 is an enlarged top perspective view of the winding hub and damper gear of the transfer device trainer of Fig. 41 including a transfer device winding fitting.
  • the embodiments of the disclosure include training versions of on-body injection devices such as the single-use injection device described in commonly assigned U.S. Patent No. 9,925,333 to Hooven et al., issued March 27, 2018, and which is hereby incorporated herein by reference in its entirety.
  • That injection device includes a internal resilient bladder that may be filled with any suitable injectable medicament, whether drug, antibiotic, biologic or other injectable, for subcutaneous injection, typically a bolus injection, into a patient while the device is being worn by the patient.
  • This injection device must be filled (wholly or partially) with the desired injectable before injection into the patient.
  • the medicament is expelled from the injection device via an injection cannula that passes through a dispense port formed in the bottom of the injection device housing.
  • a pressurized gas canister positioned within a pressure chamber is punctured when the vial is pressed down into the device via a vial elevator, with the resulting pressurized air from the pressure chamber directed to the inverted vial to displace the injectable.
  • the transfer devices are also single-use devices.
  • the vial may be a standard drug vial with a rigid container portion usually glass, open at one end and sealed by a pierceable diaphragm or septum of latex, silicone or other material.
  • the transfer devices described above receive the vial in an inverted vertical position so that the gas flows to the closed end of the vial, forcing essentially all the medicament from the vial under the force of the pressurized gas.
  • a transfer device trainer of the disclosure is indicated in general at 100 in Figs. 1 and 2.
  • An exploded view of a transfer device trainer is provided in Fig.
  • the transfer device trainer includes a housing, indicated in general at 102, and a base, indicated in general at 104 in Fig. 3, to which the housing is mounted.
  • the housing 102 includes a vial holding portion 106 and a simulated gas expansion portion 108.
  • the vial holder portion 106 houses a vial elevator shaft, indicated at 112, within which is received a vial elevator 114.
  • the vial elevator 114 vertically slides within the vial elevator shaft 112 in a telescoping fashion between a raised or extended position (illustrated in Figs. 1 and 2) and a lowered or retracted position.
  • the vial elevator shaft 112 is mounted within the vial holder 106 of the housing in a fixed manner so that it doesn’t rotate therein.
  • a cam ring 116 rotatably surrounds the vial elevator shaft 112 and features camming surfaces 117 that are engaged by camming hooks 119 positioned on splines 121 of the vial elevator 114 when it is moved downwards within the vial elevator shaft 112.
  • an inverted vial 122 passes through a vial opening 115 of the vial holding portion 106 of the housing cover 102 and the vial neck portion is inserted into, and in engagement with, the vial elevator 114.
  • the vial is then pushed downwards so that the vial elevator 114 moves downwards in the elevator shaft 112 (Figs. 3 and 4) thereby rotating the cam ring 116 due to engagement of the camming surfaces 117 with the vial elevator camming hooks 119.
  • the cam ring 116 is only capable of rotating in one direction.
  • each camming surface 117 is formed on an edge of a corresponding triangular camming member 101 .
  • Each camming member 101 is provided with a recess 103 on the inward-facing or back side that defines an internal reset camming surface 105.
  • the vial elevator camming hooks 119 are horizontally spaced from one another so that as a camming hook 119 of the vial elevator 114 travels down a camming surface 117 of the cam ring 116, and the cam ring 116 rotates, at least one neighboring camming hook enters the recess 103 on the back side of the neighboring camming member 101 .
  • the neighboring camming hook is positioned to engage an internal reset camming surface 105, and thus turn the cam ring, when the elevator 114 is pulled upwards to reset the device as described below.
  • the elevator 114 therefore acts on the cam ring cam surfaces 117 by camming it forward on the down stroke and flexing the cam ring 116 via the reset camming surfaces 105 on the up stroke.
  • the Elevator cam hooks 119 alternate between acting on a cam surface, thus advancing the cam ring forward 30 degrees (as an example only), and passing behind a cam surface, thus allowing them to flex past the cam surface on the up-stroke and therefore ending up in a position which allows them to act on the cam surface in the subsequent use.
  • the housing 102 further includes an injection device support surface 124 that, as explained in greater detail below, removably receives and supports the injection device trainer for simulated refilling of the injection device trainer with liquid medication from a vial 122 inserted into the vial elevator 114.
  • the injection device support surface is provided with a transfer device winding fitting 125, the operation of which will be explained below.
  • a pair of locator pins 126a and 126b extend upwards from the injection device support surface 124 and engage corresponding openings 127a and 127b (Fig. 21 ) formed in the bottom of the injector to prevent the injector from spinning with respect to the transfer device when mounted to the injection device support surface 124.
  • the elevator shaft base 118 is provided with an elevator locking mechanism to secure the vial elevator 114 in the fully retracted position after a vial has been inserted therein and pushed fully into the transfer device.
  • the elevator locking mechanism includes a pair of locking shuttles 132a and 132b that are slidably positioned on the elevator shaft base 118 and forced radially outwards by a compression spring 134.
  • locking shuttle 132a is provided with outward facing hook or undercut 136a
  • locking shuttle 132b is provided with outward facing hook or undercut 136b
  • Locking shuttles 132a and 132b are further provided with horizontal posts 138a and 138b, respectively, which are received within the ends of the compression spring 134 as illustrated in Fig. 7.
  • the elevator shaft base 118 is provided with a pair of shuttle guides 142a and 142b that slidably receive the flanges 144a and 144b of locking shuttles 132a and 132b, respectively.
  • the elevator is provided with inward extending locking hooks 148a and 148b.
  • locking hooks 148a and 148b engage the undercuts 136a and 136b (Figs. 7 and 9) of locking shuttles 132a and 132b (Figs. 7-9), locking the elevator and vial in place within the transfer device housing.
  • an unlocking reset tool such as the one indicated in general at 152 in Fig. 11 A, is required to unlock the two components for reset. As illustrated in Fig.
  • the reset tool includes a wedge-shaped tip 154.
  • the tip 154 is sized to pass through an unlock opening 156 (illustrated in Figs. 7, 10 and 13) formed in the elevator shaft base 118. Insertion of the tip 154 (of Fig. 11 ) through the unlock opening (as illustrated in Fig. 12) results in the tip 154 engaging and traveling up inclined surfaces 158a and 158b of the locking shuttles 132a and 132b of Figs. 8 and 9 so that the locking shuttles slide radially inwards against the urging of compression spring 134 (of Fig. 7). This causes the undercuts 136a and 136b (Figs. 7 and 9) of locking shuttles 132a and 132b to disengage the locking hooks 148a and 148b (Fig. 6) of the elevator so that the elevator is unlocked.
  • the configuration of reset tool 152 of Figs. 11A and 12 is provided as an example only.
  • the tip 154 could be positioned on the bottom of the product packaging, such as a tray or a storage box bottom 155, so that the tip extends upwards to unlock the transfer device 100 automatically by placing it within or on the packaging, storage box or storage tray.
  • the elevator 114 and vial 122 may be returned to the starting positions illustrated in Figs. 1 and 2. This may be accomplished by pulling upwards on the vial. As the vial rises from the fully inserted position, the vial elevator 114 is pulled upwards within the elevator shaft 112 of Figs. 3 and 4. As described previously, this causes the cam ring 116 to rotate back to a reset position that is properly aligned with regard to a camming hook 119 of the vial elevator 114. [0077] As shown in Figs. 3, 4, 13 and 14, the cam ring 116 is provided with downward-extending arcuate belt gripping surfaces 162. As illustrated in Figs.
  • the belt gripping surfaces of the cam ring 116 are engaged by a drive belt 164.
  • Drive belt 164 further engages a winding sheave 166 of a winding assembly, indicated in general at 170 in Figs. 13 and 14.
  • An exploded view of winding assembly 170 is presented in Fig. 15.
  • the winding assembly 170 includes a center timing shaft 172, the bottom of which is provided with the previously mentioned winding sheave 166. As illustrated in Fig. 15, the center timing shaft 172 defines a center timing shaft recess 174 within which is positioned a timing shaft post 176.
  • a clock spring assembly 177 includes a clock spring 178 and a clock spring collar 182.
  • the clock spring 178 is positioned within the clock spring collar 182 with the outer end of the clock spring secured to the collar 182.
  • the clock spring collar 182 is positioned within the center timing shaft recess 174 and an inner end of the clock spring 178 is connected to the timing shaft post 176 via a connector 184.
  • a winding hub indicated in general at 186 in Figs. 15 and 16, includes the previously mentioned transfer device winding fitting 125 (Fig. 15) and a downward extending skirt portion 188.
  • the skirt portion 188 defines a winding hub recess, indicated at 192 in Fig. 16 and is provided with screw openings 194.
  • Screws are received by and pass through the screw openings 194 so as to engage and secure the collar 182 of the clock spring assembly within the winding hub recess 192 (Fig. 16).
  • the downward extending skirt portion 188 of the winding hub has a diameter that permits it to be received within the center timing shaft recess 174.
  • the heads of the screws that pass through the openings 194 of the winding hub may be accessed (such as by a screwdriver) through slots 196 formed through the sidewall of the center timing shaft 172.
  • a damper gear indicated in general at 198 in Fig. 15, features a central opening 202 that is provided with notches 204 that face radially inwards. These notches are engaged by protrusions 206 formed on the winding hub so 186 the damper gear 198 turns with the winding hub 186.
  • a drive belt 164 engages the winding sheave 166 of the center timing shaft 172 of the winding assembly 170.
  • the center timing shaft 172 of the winding assembly 170 is also turned clockwise when viewed from the top of the device (arrow 209 in Figs. 13 and 14).
  • the rotation of the center timing shaft 172 may be approximately thirty degrees. With reference to Figs. 15 and 16, this causes the timing shaft post 176 of the center timing shaft 172 to turn relative to the collar 182 of the clock spring assembly 177 and the clock spring 178 to be partially and temporarily wound.
  • a latch release cam is rotationally mounted adjacent to the damper gear 198 and features a gear portion 218 that is engaged by the teeth 214 of the damper gear as it turns.
  • the latch release cam 216 also includes a ramp surface, indicated in general at 222, extending along a portion of the periphery of the latch release cam and having a first end portion 224 and a second end portion 226.
  • the transfer device is provided with an injection device retaining strap 227.
  • the injection device retaining strap 227 includes a pair of hinge pins 228a and 228b by which a corresponding end of the strap is pivotally secured to the transfer device.
  • the opposite end of the strap 227 is provided with an inwardly extending latching member 230.
  • the latching member 230 of Fig. 19 engages the first end portion 224 (Fig. 18) of the latch release cam 216 so that the strap 227 is secured in the positions illustrated in Figs. 1 , 17 and 20 whereby an injection device is secured to the transfer device as illustrated in Fig. 20.
  • the latch release cam 216 Upon completion of rotation of the damper gear 198, which corresponds to completion of a training session or demonstration for the transfer device, the latch release cam 216 is positioned so that the latching member 230 (Fig. 19) engages the first end 224 of the latch release cam when the injection device is repositioned on the transfer device and the strap 227 is pushed down into the position illustrated in Figs. 1 , 17 and 24.
  • the center timing shaft 172a is provided with a center post 176a that includes a slot 177 within which the inner end of the clock spring 178 is secured.
  • the winding hub 186 and damper gear 198 of Fig. 15 (corresponding to 186a and 198a in Figs. 20 and 23) have been combined into a single component winding hub and damper gear 199 having slots 201 a and 201 b.
  • the outer end of clock spring is secured via slot 197 to the inner surface of the winding hub 186a portion of the single component 199.
  • slots 201a and 201 b received fasteners 203a and 203b by which the winding hub and damper gear 199 is mounted to the center timing shaft 172a.
  • Fasteners 203a and 203b may be sized so as to slide within slots 201 a and 201 b to allow the center timing shaft 172a to turn a bit prior to engagement with, and turning of, the winding hub and damper gear 199. This simulates a delay in liquid medication flow from the transfer device to the injection device. Such a delay may occur, for example, due to pressurization and gas flow times required in the actual transfer device.
  • a spring-loaded belt tensioner indicated in general at 232, has also been added.
  • the belt tensioner includes a pulley wheel 233 that is mounted to the distal end of arm 234.
  • Arm 234 is pivotally mounted to the base 103 of the transfer device housing via fastener 235.
  • a torsion spring 236 urges the arm 234 towards, and thus pulley wheel 233 into engagement with, the outer surface of belt 264 with sufficient force that slack in the belt is eliminated.
  • Such a belt tensioner may also be provided to the embodiment of Figs. 3-17.
  • a spring pin assembly 237 has been mounted to base 103.
  • the spring pin assembly 237 includes a pin 238 which is surrounded by and in engagement with a coil spring 239.
  • the pin 238 and coil spring 239 are mounted within a mounting member 241 which is secured to the base 103.
  • the coil spring 239 engages the mounting member 241 so as to be urged towards the cam ring 116a.
  • cam ring 116a has been provided with a series of spaced beads 245 positioned around the perimeter of its bottom end. Beads 245 of the cam ring are engaged and traversed by the inward facing tip of the pin 238 (Figs. 22A and 22B) of the spring pin assembly 237 as a vial that is positioned within the vial elevator 114 is pushed down and the cam ring 116a turns in response. This provides a slight resistance as the vial and vial elevator 114 are pushed down into the fully lowered position, which simulates piercing of the vial stopper by vial spikes that are present in the non-training version of the transfer device.
  • Such spring pin arrangement and cam ring may also be provided to the embodiment of Figs. 3-17
  • An injection device trainer of the disclosure is indicated in general at 240 in Figs. 24 and 25.
  • the injection device trainer 240 includes a housing having a top portion 242 and a bottom portion 244.
  • the injection device trainer is provided with a push button 246 that is pushed to initiate a simulated injection.
  • the push button is shown in the raised position in Fig. 1 .
  • FIG. 26 The internal components of the injection device trainer 240 are illustrated in Fig. 26, where an exploded view is presented.
  • the push button 246 is mounted within a socket 256 formed within the top portion 242 of the housing so that the button may move between the raised position illustrated in Fig. 24 and a depressed or lowered position, where such movement simulates activation of the injection device.
  • socket 256 is provided with a pair of opposing button tracks 258a and 258b.
  • the button 246 is provided with a guide tab 262 which is received by, and slides within, button track 258a.
  • the button 246 also features a second guide tab, positioned on the side of the button opposite guide tab 262 and thus not visible in Fig. 26, which is similarly received by, and slides within, button track 258b of Fig. 27.
  • An alternative number of guide tabs and corresponding button tracks may be used.
  • the injection device trainer 100 includes a button claw, indicated in general at 248.
  • the button claw features a pair of flex arms 252a and 252b joined by a bridge portion 254.
  • An alternative number of flex arms may be used.
  • the button 246 features an elongated slot 264 that receives flex arm 252a so that the flex arm is free to flex therein.
  • a second elongated slot is provided on the hidden opposite side of button 246, and thus is not visible, and receives flex arm 252b in a similar fashion.
  • the button claw may optionally be integrally molded or otherwise formed with the button as a single piece.
  • a compression spring indicated at 266 in Figs. 26 and 28, features a top end which engages the bridge portion 254 of the button claw 248.
  • the bottom of the compression spring 266 engages a rotor, indicated in general at 268, so that the button 246 is urged into the raised position illustrated in Fig. 24.
  • the rotor 268 is rotatably mounted to the bottom portion 244 of the housing.
  • the rotor includes a rotor gear 272, a rotor cylinder 274 and a fill indicator 276.
  • the rotor cylinder 274 includes a central recess 278 that receives the bottom end of the compression spring 266, as illustrated in Fig. 28.
  • a ratchet gear, indicated in general at 282 in Fig. 26, includes a central opening 284 into which extend ratchet tabs 286a-286d.
  • the ratchet tabs are sized and angled so that when the rotor gear 272 (Fig. 26) is positioned within the ratchet gear central opening 284 (Fig. 26), in the manner illustrated in Fig. 28, the ratchet tabs engage the teeth of the rotor gear so that the rotor 268 may only turn in the direction of arrow 288 of Fig. 40 when the ratchet gear 272 is free to turn in the direction of arrow 288.
  • a latch indicated in general at 292 features a slanted engagement surface 294 and latch teeth 296.
  • the latch 292 is pivotally mounted to the bottom portion 244 of the housing by a pin 298 that engages opening 302 (Fig. 26) formed in the housing bottom portion.
  • a torsion spring 304 has a central loop portion that receives the pin 298 and features a pair of arms, one of which engages the latch 292 on a side opposite of the engagement surface 294 with the remaining arm engaging an interior surface of housing bottom portion 244.
  • the latch 292 is urged into a position where the latch teeth 296 engage the exterior teeth 306 of the ratchet gear 282.
  • a rotor spring which is preferably a tension spring and is indicated at 308 in Figs. 26, has a first end attached to the housing bottom portion via post 312 and a second end attached to the rotor via post 314 (shown disconnected in Figs. 29 and 30). Due to the ratchet tabs 286a-286d, the rotor gear may rotate only in a direction against the urging of the rotor spring with respect to the ratchet gear during winding of the injection device trainer.
  • a winding shaft, indicated at 316 in Figs. 26 and 28 includes a D- shaped lower portion 318 (Fig. 26) that is received within a keyed opening 322 (Fig. 31 ) that passes through the bottom of the rotor 268. As illustrated in Fig. 26, the lower portion 318 also passes through an opening 324 formed within the housing bottom portion 244, with the D-shaped lower portion 318 of the winding shaft extending out of the housing bottom portion being received within and secured to an injection device winding fitting 325, as illustrated in Fig. 25.
  • a damper 326 is rotatably mounted to the bottom portion 244 of the injection device housing and is engaged by the teeth 306 of the ratchet gear 282 so as to limit the speed at which the ratchet gear may turn.
  • the injection device trainer 240 is secured to the transfer device 100 via retaining strap 227 with the injection device winding fitting 325 (Fig. 25) in engagement with the transfer device winding fitting
  • the injection device trainer is configured to use the turning transfer device winding fitting to simulate filling of the injection device with liquid medication and to prepare the injection device trainer to perform a simulated injection.
  • winding fitting 325 of the injection device is turned in the direction of arrow 328 (Figs. 25 and 26) by the winding fitting of the transfer device. This causes the winding shaft 316 of Figs. 26 and 28 to also turn in the direction of arrow 328 (i.e. clockwise when viewed from the top of the injection device).
  • the winding and unwinding directions of the transfer device winding fitting and the injection device winding fitting may be reversed in alternative embodiments of the devices and are in no way limiting.
  • the rotor 268 As the winding shaft 316 turns, the rotor 268 also turns in the same direction (i.e. the direction of arrow 328 of Fig. 26) against the urging of tension spring 308.
  • the fill indicator 276, As the rotor rotates, the fill indicator 276, which is visible through a window formed in the upper portion 242 of the housing, rotates from a position indicating that the injection device is empty (simulated) to a position that the injection device is full or partially filled (simulated) with liquid medication.
  • the dampers 212a and 212b (Fig. 14) of the transfer device regulate the speed at which the transfer device winding fitting 125 turns, and thus the speed at which the rotor 268 of the injection device turns thus simulating the timing that an actual fill of the injection device with liquid medication takes.
  • the ratchet gear 282 is held in a fixed position by latch 292 as the rotor 268 turns within the central opening 284 of the ratchet gear while the ratchets 286a-286d of the ratchet gear pass over the teeth of the rotor gear 272 of the rotor.
  • flex arms 252a and 252b have inwardly extending locking tabs 332a and 332b that rest on radially tapered ledges 334a and 334b formed in rotor cylinder 274 prior to the button of the injection device being depressed or pushed down to dispense.
  • the button claw 248 is also moves down (in the direction of arrow 336 of Figs. 24 and 29). As this occurs, the locking tabs 332a and 332b slide down and off the tapered ledges 334a and 334b as the flex arms 252a and 252b resi liently flex apart. As they continue to travel downwards in the direction of arrows 336, the flat top surfaces of locking tabs 332a and 332b engage undercuts 338a and 338b as the flex arms 252a and 252b snap back to their original position where they are closer together. As a result, the injection device push button (246 in Fig. 24) remains in the depressed position simulating the configuration of the injection device during an injection.
  • the push button 246 is provided with a radially extending finger 342.
  • Finger 342 is positioned so as to engage and traverse down the engagement surface 294 of the latch 292 as the locking tabs 332a and 332b (Figs. 28 and 33) move downward from ledges 334a and 334b of the rotor 268 and into engagement with rotor undercuts 338a and 338b.
  • damper 326 (Fig. 29) slows the rotor rotation due to the engagement of teeth 306 of the ratchet gear with the teeth of the damper 326. This slows the rotation of the rotor 268 and permits the movement of the fill indicator 276 from the “full” position to the “empty” position to approximate the movement that would occur if the injection device was dispensing liquid medication.
  • flex arms 252a and 252b are provided with lockout members 348a and 348b which feature tapered outer surfaces 352a and 352b, respectively, and bottom stops 354a and 354b, respectively.
  • the rotor 268 is provided with lockout blocks 356a and 356b, which oppose rotor channels 346a and 346b.
  • the tapered outer surfaces 352a and 352b of lockout members 348a and 348b pass between the inner surfaces of lockout blocks 356a and 356b so that the flex arms 252a and 252b are compressed slightly towards one another.
  • the flex arms 252a and 252b spring back to their original, undeflected positions (illustrated in Figs. 28 and 33) with the rotor lockout blocks 356a and 356b positioned below the bottom stops 354a and 354b of the flex arm lockout members.
  • the injection device push button 246 Figs.
  • FIG. 34 An alternative embodiment of the injection device trainer of the disclosure is indicated in general at 400 in Fig. 34.
  • the injection device trainer 400 provides an alternative injection device winding fitting (in place of the winding fitting 325 of Fig. 25) and a fill indicator with improved operational simulation (as compared to the fill indicator 276 of Figs. 26 and 28).
  • the injection device trainer 400 of Fig. 34 features the same components and functionality as described above for the injection device trainer 240 (Figs. 24-26) with reference to Figs. 24-33.
  • the injection device trainer 400 includes a housing having a top portion 401 and a bottom portion 402. As illustrated in Fig. 35, the bottom portion 402 of the housing includes a central opening 404 that, as described in greater detail below and illustrated in Fig. 36, receives a simulated tissue tent injection needle cover 406 and a winding disk 408 of a rotor, indicated in general at 412 in Figs. 35, 37 and 38.
  • tissue tent injection needle cover 406 is secured to the bottom portion 402 of the housing in a fixed fashion while the rotor 412 is secured to the bottom portion of the housing in a limited rotation fashion. As will be explained in greater detail below, both of the above are accomplished via a tissue tent bridge indicated in general at 414 in Fig. 35.
  • the rotor 412 includes a rotor gear 416 and a rotor cylinder 418.
  • the rotor cylinder 418 includes a central recess 422 (Fig. 38) with a bottom boundary formed by the winding disk 408 of the rotor (Fig. 37).
  • the top edge of the central recess 422 is provided with a lip portion 424 that defines an undercut 426 (with an opposing undercut hidden from view in Fig. 38).
  • opposing tissue tent bridge channels 428a and 428b are also formed within the walls defining the central recess 422.
  • the tissue tent bridge 414 includes a pair of arms 432a and 432b, where each is provided with bottom mounting posts 434a and 434b.
  • the rotor 412 is positioned within the bottom portion 402 of the housing with, as illustrated in Fig. 36, the winding disk 408 positioned through the central opening of the bottom portion of the housing.
  • the arms 432a and 432b of the tissue tent bridge 414 are inserted through the corresponding tissue tent channels 428a and 428b of the rotor so that the tissue tent bridge 414 is positioned within the central recess of the rotor and, with reference to Fig. 36, the bottom mounting posts 434a and 434b (also shown in Fig. 35) of the arms of the tissue tent bridge in engagement with corresponding openings 436a and 436b formed in the bottom portion 402 of the housing.
  • the posts may be secured in this position with adhesive, interference or snap fit arrangements, connectors or other fastening arrangements known in the art.
  • the tissue tent bridge 414 also includes shoulders 438a and 438b.
  • the rotor 412 is turned slightly in the direction of arrow 456 into the position illustrated in Fig. 39 so that the shoulders 438a and 438b of the tissue tent bridge engage the undercuts 426 (Fig. 38) of the rotor.
  • the tissue tent bridge 414 includes a central cup portion 442 that receives the bottom end of the push button compression spring (such as compression spring 266 of Fig. 26).
  • the simulated tissue tent injection needle cover 406 is next positioned as shown in Fig. 36 and, with reference to Fig. 35, a screw 446 or other fastener is directed through a central opening 448 formed in the bottom of the tissue tent bridge so as to engage a corresponding threaded bore formed in the top of the simulated tissue tent injection needle cover 406.
  • a screw 446 or other fastener is directed through a central opening 448 formed in the bottom of the tissue tent bridge so as to engage a corresponding threaded bore formed in the top of the simulated tissue tent injection needle cover 406.
  • the tissue tent bridge 414 and the tissue tent injection needle cover 406 of Fig. 35 are formed as a single piece.
  • the central opening formed in winding disk 408 of the rotor 412 is sized to permit the tissue tent injection needle cover 406 to pass down therethrough and into the position illustrated in Fig. 36 during assembly of the injection device trainer.
  • a ratchet gear indicated in general at 452 in Fig. 40, includes a central opening into which extend ratchet tabs 454.
  • the ratchet tabs are sized and angled so that when the rotor gear 416 (also shown in Figs. 38 and 39) is positioned within the ratchet gear central opening, in the same manner as the previous embodiment illustrated in Fig. 28, the ratchet tabs 454 engage the teeth of the rotor gear 416 so that the rotor 412 may only turn in the direction of arrow 456 of Fig. 40 when the ratchet gear 452 is free to turn in the direction of arrow 456.
  • the ratchet gear As in the embodiment of Figs.
  • the ratchet gear is only free to turn in the direction of arrow 456 when a latch (such as 292 in Figs. 26, 29 and 30) is actuated by pushing a button (458 of Fig. 34) of the injection device 400.
  • a latch such as 292 in Figs. 26, 29 and 30
  • a rotor spring which is preferably a tension spring and is indicated at 462 in Fig. 39, has a first end attached to the housing bottom portion via a post (not shown) and a second end attached to the rotor via tab 464 (with the spring shown disconnected in Fig. 39), so that the rotor 412 is urged to rotate in the direction of arrow 456. Due to the ratchet tabs 454, the rotor gear may rotate only in a direction against the urging of the rotor spring with respect to the ratchet gear during winding of the injection device trainer.
  • a fill indicator ring indicated in general at 472 in Figs. 39 and 40 is rotatably positioned within the bottom portion 42 of the housing.
  • the fill indicator ring is provided with a fill indicator 474 which, as in the embodiment of Figs. 24- 33, is visible through a window formed in the upper portion 401 (Fig. 34) of the housing and rotates between a position indicating that the injection device is empty (simulated) to and from a position indicating that the injection device is full or partially filled (simulated) with liquid medication.
  • the fill indicator ring is also provided with a fill indicator hook 476.
  • a rotor hook 466 extends radially from the rotor 412.
  • An elastic member such as an elastic band 482 or other elastic connector joins the rotor hook 466 and the fill indicator hook 476.
  • the fill indicated 474 is shown in the empty position (i.e. corresponding to the injection device being simulated as empty) in Figs. 39 and 40.
  • a fill indicator stop wall 484, featuring a stop surface 486, is positioned under the fill indicator and extends radially inwards towards the rotor.
  • the fill indicator hook 476 trails the rotor hook 466 until the stop surface 486 engages a stop tab 488 or other stop structure formed on, or otherwise connected to, the bottom portion 402 of the injection device housing.
  • movement of the fill indicator hook 476, and thus the fill indicator 474 stops, while movement of the rotor 412 and thus rotor hook 466, continues in the direction of arrow 484.
  • Elastic connector 482 stretches as the rotor hook moves away from the fill indicator hook until the injection device is fully wound (representing the filled condition). For example, movement of the rotor hook could stop short of the post 492 of Fig. 39 that supports the ratchet gear latch described previously.
  • the injection device of Figs. 34-40 is wound by turning the winding disk 408 of Fig. 36 in the direction of arrow 494.
  • an embodiment of the injection device indicated in general at 496 in Fig. 41 , is provided with a transfer device winding fitting 498 that includes upward extending winding posts 502 (also shown in Fig. 42).
  • the transfer device winding fitting 496 is positioned on top of a winding hub and damper gear 504, which is turned in the same manner as winding hub and damper gear 199 of Figs. 20-23.
  • the transfer device winding fitting 498 rotates with respect to the injection device support surface 506 of Fig. 41 .
  • the bottom side of winding disk 408 forms an injection device winding fitting including sockets 508 that correspond to and receive the winding posts 502 of Figs. 41 and 42 when the injection device 400 (Fig. 33) is mounted on the injection device support surface 506 of the transfer device 496 of Fig. 41.
  • the winding disk 408 of the injection device is turned by the rotating transfer device winding fitting 496 so that the injection device is wound during a simulated filling by the transfer device.
  • the transfer device winding fitting 498 features a central recess 512 that receives the simulated tissue tent injection needle cover 406 (Figs. 35 and 36), which remains stationary while the injection device is being wound, when the injection device is mounted on the transfer device.

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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Pulmonology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Des versions d'entraînement réutilisables de dispositifs d'injection et de transfert ont des caractéristiques qui permettent de simuler le fonctionnement des dispositifs d'injection et de transfert, tout en leur permettant d'être réinitialisés en vue d'une utilisation future après une session d'entraînement ou de démonstration.
PCT/US2025/025957 2024-04-23 2025-04-23 Dispositifs d'entraînement de dispositif d'injection et de transfert Pending WO2025226810A1 (fr)

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US202463637666P 2024-04-23 2024-04-23
US63/637,666 2024-04-23

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WO2025226810A1 true WO2025226810A1 (fr) 2025-10-30

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160144105A1 (en) * 2013-06-18 2016-05-26 Enable Injections, Llc Vial transfer and injection apparatus and method
US20180207363A1 (en) * 2015-06-05 2018-07-26 Aptar France Sas Auto-injector
US20230009541A1 (en) * 2019-12-13 2023-01-12 Eli Lilly And Company Multi-use drug-delivery device
US20230190582A1 (en) * 2017-10-16 2023-06-22 Enable Injections, Inc. Pressurized Gas Powered Liquid Transfer Device and System
JP2024516958A (ja) * 2021-04-13 2024-04-18 イージーアイブイ リミテッド デバイス

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160144105A1 (en) * 2013-06-18 2016-05-26 Enable Injections, Llc Vial transfer and injection apparatus and method
US20180207363A1 (en) * 2015-06-05 2018-07-26 Aptar France Sas Auto-injector
US20230190582A1 (en) * 2017-10-16 2023-06-22 Enable Injections, Inc. Pressurized Gas Powered Liquid Transfer Device and System
US20230009541A1 (en) * 2019-12-13 2023-01-12 Eli Lilly And Company Multi-use drug-delivery device
JP2024516958A (ja) * 2021-04-13 2024-04-18 イージーアイブイ リミテッド デバイス

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