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WO2025226792A1 - Dispositif d'entraînement de dispositif de transfert alimenté au gaz - Google Patents

Dispositif d'entraînement de dispositif de transfert alimenté au gaz

Info

Publication number
WO2025226792A1
WO2025226792A1 PCT/US2025/025931 US2025025931W WO2025226792A1 WO 2025226792 A1 WO2025226792 A1 WO 2025226792A1 US 2025025931 W US2025025931 W US 2025025931W WO 2025226792 A1 WO2025226792 A1 WO 2025226792A1
Authority
WO
WIPO (PCT)
Prior art keywords
vial
clicker
cam ring
rod
spool valve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2025/025931
Other languages
English (en)
Inventor
Rowan Joseph Converse
Kory Gunnerson
Joshua TRANSUE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enable Injections Inc
Original Assignee
Enable Injections Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enable Injections Inc filed Critical Enable Injections Inc
Publication of WO2025226792A1 publication Critical patent/WO2025226792A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1782—Devices aiding filling of syringes in situ
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/02—Equipment for testing the apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/04—Tools for specific apparatus
    • A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs

Definitions

  • the present subject matter relates generally to devices for transferring medication from a vial to a medical device and, in particular, to a gas- powered transfer device including training features.
  • Injection devices that are worn by a patient temporarily or for extended periods are well known in the medical field.
  • the subject matter of this application relates to training versions of transfer devices for use particularly, but not exclusively, with the injection device described in commonly assigned U.S. Patent No. 9,925,333 to Hooven et al., issued March 27, 2018, and which is hereby incorporated herein by reference in its entirety.
  • That injection device includes an internal resilient bladder that may be filled with any suitable injectable medicament, whether drug, antibiotic, biologic or other injectable, for subcutaneous injection, typically a bolus injection, into a patient while the device is being worn by the patient.
  • This injection device must be filled (wholly or partially) with the desired injectable before injection into the patient.
  • transfer devices for transferring an injectable into the injection device from a source such as a vial. These transfer devices drive the injectable from a vial into the injection device using pressurized gas canisters. In each transfer device, a pressurized gas canister positioned within a pressure chamber is punctured with the resulting pressurized air directed to the inverted vial to displace the injectable. As a result, the transfer devices are single-use devices.
  • a reusable training transfer device includes a vial elevator configured to receive a vial and a vial elevator shaft within which the vial elevator moves between a raised position and a lowered position.
  • a cam ring is rotatably positioned around the vial elevator shaft and includes a camming surface that is traversed by the vial elevator as the vial elevator moves from the raised position to the lowered position whereby the cam ring rotates.
  • a gas expansion housing includes a gas expansion chamber.
  • a flexible pusher features a first end connected to the cam ring and a second end.
  • a spring seat is connected to the second end of the flexible pusher.
  • a spool valve includes a spool valve housing having a spool valve cylinder and first and second fluid ports in fluid communication with the spool valve cylinder and a vent port in fluid communication with the spool valve cylinder. The vent port also is in communication with atmosphere and the first vent port is in fluid communication with the gas expansion chamber.
  • a spool is slidably positioned within the spool valve cylinder. A pair of seals are spaced apart along and mounted on the spool so that a seal zone is formed between the pair of seals within the spool valve cylinder.
  • a pusher compression spring is positioned between the spring seat and the spool.
  • a spring return device includes a spring return device housing including a spring return device cylinder in fluid communication with the gas expansion chamber.
  • a spring return device piston is slidably positioned within the spring return device cylinder.
  • a stop pin abuts the spool valve housing, is connected to the spring return device piston, passes through the spring return device housing and is movable between an extended position and a retracted position.
  • a spool line has a first line end connected to the cam ring and a second line end connected to the spool.
  • a cam ring spring is operatively connected to the cam ring so as to urge it into a first position, where the vial elevator is in the raised position, from a second position, where the vial elevator is in the lowered position.
  • the flexible pusher, pusher compression spring, spring return device and spool line are configured so that when the cam ring is in the second position and a pressure level in the gas expansion chamber is above a predetermined level, the seal zone of the spool valve is in fluid communication solely with the first and second ports of the spool valve, and when the cam ring is in the second position and a pressure level in the gas expansion chamber is below a predetermined level, the seal zone is in fluid communication with the first and second ports of the spool valve and the vent port of the spool valve. When the cam ring is in the first position, the seal zone is in fluid communication solely with the first port of the spool valve.
  • a reusable training transfer device includes a vial elevator that receives a vial and a vial elevator shaft within which the vial elevator moves between a raised position and a lowered position.
  • a cam ring is rotatably positioned around the vial elevator shaft and includes a camming surface that is traversed by the vial elevator as the vial elevator moves from the raised position to the lowered position whereby the cam ring rotates.
  • a pushing surface is positioned on the cam ring.
  • a clicker rod housing includes a clicker rod housing cylinder and a stop surface positioned within the clicker rod housing cylinder.
  • a clicker rod includes a flexible shaft portion having a contact end and an enlarged plunger positioned within the clicker rod housing cylinder.
  • a clicker rod compression spring is positioned within the clicker rod housing cylinder and is configured to urge the plunger of the clicker rod into engagement with the stop surface of the clicker rod housing.
  • the clicker rod, clicker rod compression spring and clicker rod housing are configured so that as the vial elevator is moved from the raised to the lowered position, the cam ring rotates so that the pushing surface engages the contact end of the clicker rod and pushes that clicker rod so that the plunger compresses the clicker rod compression spring and moves away from the stop surface, and the pushing surface then moves off of the contact end of the clicker rod so that the clicker rod compression spring expands and pushes the plunger back into contact with the stop surface.
  • a reusable training vial in another aspect, includes a sidewall, an end and a neck region defining a hollow space.
  • the sidewall and neck region include an annular fluid passage.
  • a cap is connected to the neck region and defines a cap fluid chamber that is sized so as to be capable of containing a maximum amount of liquid that may be placed within the annular fluid passage.
  • the cap further includes a flow opening that is in fluid communication with the flow passage and the cap fluid chamber and configured so that when the training vial is inverted, all of the fluid within the annular fluid passage flows into the cap fluid chamber.
  • a reusable training transfer device in another aspect, includes a vial elevator that receives a vial and a vial elevator shaft within which the vial elevator moves between a raised position and a lowered position.
  • a syringe cylinder is positioned within a bottom portion of the vial elevator shaft.
  • a passage is in fluid communication with the syringe cylinder and configured to direct liquid from the syringe cylinder to an injection device connected to the transfer device when liquid is forced out of the syringe cylinder.
  • a syringe piston is positioned within the syringe cylinder and configured to be engaged and moved as the vial elevator is moved to the lowered position.
  • a reusable training transfer device in another aspect, includes a vial elevator configured to receive a vial and a vial elevator shaft within which the vial elevator moves between a raised position and a lowered position.
  • a cam ring is rotatably positioned around the vial elevator shaft and includes a camming surface configured to be traversed by the vial elevator as the vial elevator moves from the raised position to the lowered position whereby the cam ring rotates.
  • a gas expansion housing includes a gas expansion chamber.
  • a flexible pusher features a first end connected to the cam ring and a second end.
  • a spring seat is connected to the second end of the flexible pusher.
  • a spool valve includes a spool valve housing having a spool valve cylinder and first and second fluid ports in fluid communication with the spool valve cylinder and a vent port in fluid communication with the spool valve cylinder. The vent port is also in communication with the atmosphere and the first vent port in fluid communication with the gas expansion chamber.
  • a spool is slidably positioned within the spool valve cylinder. A pair of seals are spaced apart along and mounted on the spool so that a seal zone is formed between the pair of seals within the spool valve cylinder.
  • a pusher compression spring is positioned between the spring seat and the spool.
  • a spring return device includes a spring return device housing including a spring return device cylinder in fluid communication with the gas expansion chamber.
  • a spring return device piston is slidably positioned within the spring return device cylinder.
  • a stop pin abuts the spool valve housing and is connected to the spring return device piston, passes through the spring return device housing and is movable between an extended position and a retracted position.
  • a spool line has a first line end connected to the cam ring and a second line end connected to the spool.
  • a cam ring spring is operatively connected to the cam ring so as to urge it into a first position, where the vial elevator is in the raised position, from a second position, where the vial elevator is in the lowered position.
  • the flexible pusher, pusher compression spring, spring return device and spool line are configured so that when the cam ring is in the second position and a pressure level in the gas expansion chamber is above a predetermined level, the seal zone of the spool valve is in fluid communication solely with the first and second ports of the spool valve.
  • the seal zone is in fluid communication with the first and second ports of the spool valve and the vent port of the spool valve.
  • the seal zone is in fluid communication solely with the first port of the spool valve.
  • a pushing surface is positioned on the cam ring.
  • a clicker rod housing includes a clicker rod housing cylinder and a stop surface positioned within the clicker rod housing cylinder.
  • a clicker rod includes a flexible shaft portion having a contact end and an enlarged plunger positioned within the clicker rod housing cylinder.
  • a clicker rod compression spring is positioned within the clicker rod housing cylinder and is configured to urge the plunger of the clicker rod into engagement with the stop surface of the clicker rod housing.
  • the clicker rod, clicker rod compression spring and clicker rod housing are configured so that as the vial elevator is moved from the raised to the lowered position the cam ring rotates so that the pushing surface engages the contact end of the clicker rod and pushes that clicker rod so that the plunger compresses the clicker rod compression spring and moves away from the stop surface. The pushing surface then moves off of the contact end of the clicker rod so that the clicker rod compression spring expands and pushes the plunger back into contact with the stop surface.
  • Figure 1 is a schematic view of a single vial pressurized gas powered transfer system and an injection device.
  • Figure 2 is a schematic view of a dual vial pressurized gas powered transfer system and an injection device.
  • Figure 3 is perspective view of an embodiment of the pressurized gas powered transfer device of the disclosure with an injection device attached.
  • Figure 4 is a perspective view of the pressurized gas powered transfer device of Figure 3 with the injection device removed.
  • Figure 5A is an enlarged perspective view of the vial holder of the transfer device of Figures 3 and 4 with the housing cover removed.
  • Figure 5B shows the vial holder of Figure 5A with the cam ring and elevator shaft removed.
  • Figure 6A is an enlarged top plan view of the vial elevator of Figures 5A and 5B.
  • Figure 6B is a perspective view of the vial elevator of Figure 6A.
  • FIG. 7 is an enlarged perspective view of the elevator shaft of Figure
  • Figure 8 is an enlarged perspective view of the cam ring of Figure 5A.
  • Figure 9 is a perspective view of an embodiment of the transfer device of the disclosure and a vial containing a liquid medication.
  • Figure 10A is a bottom perspective view of the transfer device of Figure 3.
  • Figure 10B shows the transfer device of Figure 10A with the baseplate removed.
  • Figure 11 is an enlarged partially transparent perspective view of the vial spike of the transfer device of Figures 3 and 4.
  • Figure 12 is an alternative view of Figure 11 .
  • Figure 13 is a partially transparent sectional view of the transfer device of Figure 4.
  • Figure 14A is a perspective view of the transfer device of Figures 3 and 4 with the housing cover removed.
  • Figure 14B shows the transfer device of Figure 14A with the expansion chamber housing removed.
  • Figure 15 is an alternative perspective view of the transfer device of Figure 3.
  • Figure 16 is an enlarged perspective view of the retainer strap of Figure 15.
  • Figure 17 is an enlarged perspective view of the pressure relief piston assembly, the pivot plate and a portion of the retainer strap of the transfer device of Figures 3, 4 and 15.
  • Figure 18 is an enlarged perspective view of the transfer device of Figure 3 with the housing cover removed.
  • Figure 19 is an enlarged to perspective view of the vent housing and venting bore of the transfer device of Figure 18 with the pivot plate and the pressure relief piston assembly removed.
  • Figure 20 is a bottom perspective review of the vent housing and venting bore of Figure 19.
  • Figure 21 is an enlarged perspective view of the core of the pressure relief piston assembly of the transfer device of Figures 3, 4 and 15.
  • Figure 22 is an enlarged perspective view of the sealing ring of the pressure relief piston assembly of the transfer device of Figures 3, 4 and 15.
  • Figure 23 is a perspective view of the pressure relief piston assembly of the transfer device of Figures 3, 4 and 15.
  • Figure 24 is an enlarged top perspective view of the pivot plate of the transfer device of Figures 3, 4 and 15.
  • Figure 25 is an top perspective view of the pressure relief piston assembly and the pivot plate of Figures 23 and 24.
  • Figure 26 is a perspective of components of a first training transfer device of the disclosure in an initial state.
  • Figure 27A is a top plan view of the training transfer device of Figure 26 in an initial, unpressurized state.
  • Figure 27B is a top plan view of the training transfer device of Figure 27A in a pressurized state.
  • Figure 27C is a top plan view of the training transfer device of Figure 27B after an inverted vial has been inserted and lowered.
  • Figure 27D is a top plan view of the training transfer device of Figure 27C after the pressure within the gas expansion chamber has dropped below a predetermined level.
  • Figure 27E is a top plan view of the training transfer device of Figure
  • Figure 28A is a side elevational view of a training vial of the disclosure in an upright position.
  • Figure 28B illustrates the training vial of Figure 28A being inverted.
  • Figure 28C is a cross sectional view taken along the longitudinal axis of the inverted training vial of Figure 28B.
  • Figure 29A is a perspective partial sectional view of a second training device of the disclosure with an inverted vial inserted but not lowered.
  • Figure 29B is a perspective partial sectional view of the second training device of Figure 29A after the inverted vial is lowered.
  • Figure 30 is a perspective view of components of a third training transfer device of the disclosure in an initial state.
  • Figure 31 A is a top plan view of the training transfer device of Figure 30 in a starting position.
  • Figure 31 B is a top plan view of the training transfer device of Figure
  • Figure 31 C is a top plan view of the training transfer device of Figure 31 B after the cam ring has rotated past and released the clicker rod.
  • Figure 32 is an enlarged perspective view of the training transfer device of Figure 30 illustrating a slot allowing the clicker rod to rotate out of the way to allow the cam ring to reset.
  • Fig. 1 is a diagrammatic view of a single vial transfer system, including a pressure vessel in the form of a prefilled pressurized gas cylinder or cartridge 100, a flow restrictor and/or pressure regulator 101 , a liquid medicament vial 102 and an injection device 103.
  • the gas cylinder may be any suitable cylinder commercially available or may be a custom cylinder.
  • a variety of potential cylinders are available with high pressure gas filled disposable cylinders in capacities from 1 to 1000cc.
  • the cylinders may be charged to suitable pressures up to 2000-3000 psig or more.
  • the cylinder may have a volume of 10 ml or less, and more preferably, less than 5 ml, such as 1-2 ml, pressurized to 500 psig or more, such as from 900 psig up to 2000-3000 psig or more.
  • the gas may be any suitable gas, such as, but not exclusively, an inert gas. As it will come in contact with medicament, the gas is preferably pathogen free - i.e. , free of active pathogens. Nitrogen or argon may be suitable gases. When released from the cylinder, such as by puncture by a piercing pin, the gas is directed through a suitable flow path from the cylinder through the flow restrictor and/or pressure regulator 101 to the vial 102. Alternatively, the gas that exits the cylinder could be directed through a filter with pore size of 0.2pm or less to filter the gas.
  • the flow restrictor and/or pressure regulator 101 may be of any suitable configuration.
  • the flow restrictor and pressure regulator may take the form of a chamber formed in a device within which the cartridge is positioned and to which the vial 102 and injection device 103 are attached. From the restrictor/regulator, flow path 104 conducts the gas to the vial 102.
  • the restrictor/regulator could take the form of a filter described above.
  • the vial 102 may be a standard drug vial with a rigid container portion 105 usually glass, open at one end and sealed by a piercable diaphragm or septum 106 of latex, silicone or other material.
  • the present process is preferably carried out with the vial in an inverted vertical position so that the gas flows to the closed end of the vial, forcing essentially all the medicament from the vial under the force of the pressurized gas.
  • flow path 107 directs the medicament under the pressure of the gas to a suitable vessel such as an injection device 103, an example of which is described in commonly assigned prior U.S. Patent No. 9,925,333, noted previously.
  • the injection device may have a liquid reservoir, such as an expandable reservoir for receiving the medicament, for example a reservoir that expands under pressure from the medicament.
  • the reservoir may be biased to expel the medicament upon user actuation of the injection device once removed from the flow path 107.
  • the injector capacity can be 1-50mL.
  • the undersurface of the injection device 103 may include a filling port 108 and a dispense port 112.
  • the filling port 108 is the interface that allows the transfer apparatus filling path 107 to transfer liquid to the injection device 103.
  • the filling port 108 preferably includes a check valve to prevent pressurized injectable from leaking out of the injection device 103 when the injection device is removed from the transfer apparatus and the filling port 108 is removed from the filling path 107.
  • the medicament is expelled from the injection device 103 via an injection cannula that passes through the dispense port 112.
  • Figure 2 is a diagrammatic view of a pressurized gas powered dual vial re-suspension and transfer system, including a pressure vessel in the form of a prefilled pressurized gas cylinder or cartridge 120, a flow restrictor and/or pressure regulator 121 , a liquid diluent vial 122D, a medicament vial 122M and the injection device 103 of Fig. 1. (Each vial 122D and 122M could also contain liquid medicament).
  • the gas cylinder 120 may be any suitable cylinder commercially available or may be a custom cylinder.
  • the gas may be any suitable gas, such as, but not exclusively, an inert gas preferably pathogen free - i.e. , free of active pathogens.
  • an inert gas preferably pathogen free - i.e. , free of active pathogens.
  • the gas is directed through a suitable flowpath from the cylinder through the flow restrictor and/or pressure regulator 121 into the diluent vial 122D.
  • the gas that exits the cylinder could be directed through a filter with pore size of 0.2pm or less to filter the gas.
  • the flow restrictor and/or pressure regulator 121 may be of any suitable configuration, including a chamber formed in a device within which the cartridge is positioned and to which the vials 122D and 122M and injection device 103 are attached. From the restrictor/regulator, flow path 124 conducts the gas to the vial 122D.
  • the restrictor/regulator could take the form of a filter described above.
  • the diluent (or first liquid medicament) vial 122D and medicament (or second liquid medicament) vial 122M may each be of standard drug vial configuration with a rigid container portion usually glass, open at one end and sealed by a piercable diaphragm or septum 126D and 126M of latex, silicone or other material.
  • the present process is preferably carried out with the vials in inverted vertical position so that the gas flows to the closed end of the vials, forcing essentially all the diluent and/or medicament from the vials under the force of the pressurized gas, before any gas exits the medicament vial.
  • flow path 127D directs the diluent (or liquid medicament) under the pressure of the gas into the medicament vial 122M, where it may re-suspend the medicament if in a dry of lyophilized form or dilute the medicament if in liquid concentrated form (or simply combine or mix with the medicament if in liquid non-concentrated form).
  • diluent or first liquid medicament
  • flow path 127M directs the diluent (or liquid medicament) under the pressure of the gas into the medicament vial 122M, where it may re-suspend the medicament if in a dry of lyophilized form or dilute the medicament if in liquid concentrated form (or simply combine or mix with the medicament if in liquid non-concentrated form).
  • any suitable vessel such as an injection device 103 as disclosed in the previously identified PCT application.
  • FIG. 140 An embodiment of the pressurized gas powered transfer device of the disclosure is indicated in general at 140 in Figs. 3 and 4.
  • the transfer device includes a housing cover 136 and a baseplate 138 (Figs. 5A, 5B and 10A).
  • the transfer device includes two main portions: (1) a vial holder portion, indicated in general at 142, and (2) a gas expansion portion, indicated in general at 144.
  • an injection device 103 may be docked to the gas expansion portion 144 to receive a liquid medicament.
  • FIG. 3 While the embodiments disclosed below use a single vial, alternative embodiments include transfer stations that may accommodate two or more vials in the manner illustrated in Figure 2.
  • embodiments of the transfer device discussed below are single use, disposable devices, alternative embodiments include reusable transfer devices.
  • the vial holder 142 includes a vial elevator shaft, indicated at 146 in Figs. 3 and 4 within which is received a vial elevator, indicated in general at 148.
  • a vial elevator indicated in general at 148.
  • the vial elevator 148 vertically slides within the vial elevator shaft 146 in a telescoping fashion between a raised or extended position, wherein the vial elevator 148 is in the position illustrated in Figs. 3-5B and 9, and a lowered or retracted position, wherein the vial elevator 148 is positioned down within the vial elevator shaft 146.
  • the vial elevator shaft 146 is secured to a passage plate 190 of the transfer device in a fixed fashion. More specifically, the bottom portion of the vial elevator shaft 146 includes hooks (one of which is illustrated at 139 in Fig. 7) that engage rectangular loop structures 147a-147c (Fig. 5B) of the passage plate 190 in a snap fit connection.
  • the vial elevator 148 includes a circular rim 152 from which lock arms 154a-154d downwardly extend.
  • the distal end of each lock arm 154a-154d is bifurcated so that each features a claw 155a- 155d defining a notch 157a-157d.
  • the upper portion of each lock arm 154a-154d includes a vial locking shoulder 178a-178d.
  • splines 156a-156d extend down from the rim 152 with each including an outward facing camming hook 158a-158d.
  • Stop tabs 162a-162d radially extend from a central bottom portion of the elevator, and each features a stop pin 164a-164d. The distal ends of the stop tabs 162a-162d engage the distal tips of claws 155a-155d so that inward movement of the claws is blocked.
  • An opening 166 (Figs. 6A and 6B) is formed in the center of the bottom of the vial elevator 148 and receives an upwardly pointing vial spike mounted to the passage plate 190 (Figs. 5A and 5B), as will be explained in greater detail below.
  • the vial elevator shaft has a sidewall 168 that includes inwardly facing channels 174a-174d that receive the splines 156a and 156b of the vial elevator 148 in a sliding fashion to provide radial alignment of the vial elevator in the vial elevator shaft and to provide a smooth transition as the vial elevator moves.
  • the inner surface of sidewall 168 includes inwardly extending cam ramps 170a-170d.
  • a cam ring indicated in general at 182 in Figs. 5A and 8, includes a sidewall 184 having notches and a central opening 188. Each notch includes an edge so that camming surfaces 186a-186d are defined.
  • the central opening of the cam ring 182 is sized to receive the vial elevator shaft 146 so that the cam ring is rotatably positioned upon the passage plate 190.
  • the hook 158a of spline 156a is positioned at the top of the camming surface 186a of the cam ring 182.
  • the hooks 158b-158d of splines 156b-156d are in the same position with respect to camming surfaces 186b-186d.
  • the vial elevator 148 moves downwards (in the direction of arrow 169 of Fig. 5A) into the stationary vial elevator shaft 146 towards the retracted position.
  • each vial can have a capacity of 1-50mL with neck finishes of 13-20mm.
  • a user attempts to push the vial elevator 148 down into the vial elevator shaft 146 without a vial in the vial elevator, as mentioned previously, inward travel of the claws 155a-155d on the distal ends of the lock arms 154a- 154d is prevented due to engagement with the distal ends of the stop tabs 162a- 162d so as to prevent the vial elevator 148 from being moved into the retracted position.
  • the spacing of the bottom of the passage plate (190 of Figs.
  • the baseplate 138 covers the bottom of the housing 136 of the transfer device 140.
  • removal of the baseplate reveals a passage plate, indicated in general at 190, and a gas expansion chamber 194, where the latter serves as a source of pressurized gas for pressurizing the vial as will be described below.
  • the gas expansion chamber 194 is provided with brackets 202 configured to retain and support a gas cartridge 204 (shown in transparency in Fig. 10B) containing a compressed gas, such as compressed nitrogen.
  • a compressed gas such as compressed nitrogen.
  • cartridges containing other types of compressed or pressurized gases may be used.
  • the gas cartridge is punctured to provide pressurized air to drive liquid from a vial (153 in Fig. 9) to an injection device (103 in Fig. 3) that is connected to the transfer device 140.
  • the passage plate 190 is provided with a filter recess 206 for holding a filter 208 through which, as explained in greater detail below, fluid travels from the vial spike hub to an injection device mounted to the transfer device.
  • the passage plate may be formed from plastic with the passages cut, molded or otherwise formed therein.
  • the inlet of the gas passage 212 is in fluid communication with the gas expansion chamber 194, while the outlet of the liquid passage 214 is in fluid communication with the filter recess 206.
  • Integrating the gas and liquid passages 212 and 214 into the passage plate provides at least the advantages of manufacturing efficiency and shorter passage lengths. The latter reduces pressure drop of fluids traversing the passages and therefore permits lower pressure gas canisters to be used. This construction also facilitates scalability of the transfer device.
  • the baseplate, housing cover, passage plate and other components of the transfer device may be constructed out of plastic and secured together with laser bonding, ultrasonic welding or adhesive.
  • the inlet of the liquid passage 214 is in fluid communication with the lower end of a vial spike, indicated in general at 216, via duct 218.
  • Duct 218 is located within a boss, illustrated at 219 in Figs. 5B and 11 , that is formed on the top surface of the passage plate 190 and positioned below the central portion of the vial elevator (148 of Figs 5A and 5B).
  • the vial spike 216 is secured within a bore of the boss 219 via adhesive to prevent fluid “short circuits” with regard to the gas passage 212.
  • the vial spike 216 may take the form of a cannula, which is preferably constructed from stainless steel, having a pointed tip that forms a liquid opening 220.
  • a gas tube 222 features a gas outlet opening 224 and extends through the vial spike 216.
  • the lower end of the gas tube 222 is secured within the passage plate 190 and is in fluid communication with the outlet of the gas passage 212.
  • the gas tube may be constructed from polyamide.
  • two separate spikes with independent lumens may be used as the vial spike and the gas tube.
  • the pointed tip of the vial spike 216 passes through the vial diaphragm or septum when the vial elevator 148 of Figs. 5A-6B is moved into the lowered and retracted position (whereby the vial spike passes through the central opening 166 of the vial elevator).
  • the vial spike 216 and the gas tube 222 provide two fluid paths - one to permit entry of compressed gas to force the liquid out of the vial, and one for the exiting liquid to the injection device.
  • Liquid medication in the vial is forced by pressurized gas to exit through the vial spike opening 220, duct 218 and out through liquid passage 214 to the lower portion or inlet side of the vent recess 206.
  • the housing 136 of the transfer device 140 includes an injection device support surface 227.
  • An injection device port such as transfer cannula 229, passes through the injection device support surface 227.
  • a top end portion of the transfer cannula 229 enters a fill port of an injection device positioned on the injection device support surface (as illustrated by injection device 103 of Fig. 3).
  • the bottom end portion of the transfer cannula 229 is in fluid communication with the upper or outlet side of the filter recess 206.
  • the transfer cannula may be a 19 gauge tube having a filleted edge that reduces the risk of damaging a fill septum of the injection device.
  • the vent filter 208 is used to vent the front end and back end air from the system during the transfer of drug, keeping air from entering the injection device. More specifically, as explained above, a pressurized canister is punctured and is used as the driving force to push liquid and air from a vial. The empty liquid passage 214 between the vial spike 216 and the filter recess (and thus filter 208) is filled with front end air that should be vented from the system before liquid can be pushed into the injection device.
  • the filter recess is provided with an air outlet port 231 , which is formed in a filter recess cover 233.
  • the filter 208 (Fig. 13) includes a hydrophilic membrane and a hydrophobic membrane, with a fluid chamber positioned there between.
  • the filter recess 206 receives fluid from the liquid passage 214.
  • the front end air trapped in the fluid path passes through the hydrophobic membrane of the filter 208 and out of the air outlet port 231 and into the atmosphere.
  • the filtered liquid passes through the hydrophilic membrane of the filter 208, out through the transfer cannula 229 and into the injection device.
  • the front end air is vented due to the inherent flow restriction of the hydrophilic membrane, coupled with the pressure required to fill the injection device. These factors force the front end air to find the path of least resistance when being sent through the filter 208, and that is through the hydrophobic membrane and through air outlet port 231 (Fig. 10A) rather than through the restrictive hydrophilic membrane and into the injection device.
  • the hydrophilic membrane of the vent filter allows liquid to pass through it and enter the injection device. Once the hydrophilic membrane is wetted by the liquid, it will not allow air to pass through it, only liquid, thus keeping the air from entering the injection device.
  • the hydrophilic filter also has the capability of not only filtering air but also aggregate or particulate from the drug product from being transferred into the injection device.
  • the gas expansion chamber 194 is pressurized when the gas cartridge 204 (Fig. 10B) positioned therein is punctured.
  • the cartridge puncture mechanism for doing so will now be described.
  • a gas expansion chamber housing 234 includes a flexible wall portion 236.
  • the flexible wall portion 236 may be constructed of plastic with a thickness of approximately .030” for flexibility.
  • a trigger spring indicated in general at 238, includes a hammer portion
  • the hammer portion 242 is urged into engagement with the flexible wall portion 236 of the gas expansion chamber housing 234 by the resilient forces of the trigger spring, as illustrated in Fig. 14A.
  • the trigger spring 238 may be made of metal or steel.
  • a link 252 includes a first notch 254 and a second notch 256.
  • the first notch 254 is engaged by the latch portion
  • the second notch 256 is engaged by a link hook 258 formed on or secured to the cam ring 182.
  • the link may be made of steel, metal or plastic.
  • a gas cartridge cap 262 features an inner surface that holds a puncture tip, indicated in phantom at 264, having a sharp point.
  • the cap 262 holds the puncture tip 264 in a position where the puncture tip opposes a seal of the pressurized gas cartridge 204.
  • the cap 262 is positioned adjacent to, and in engagement with, an inner surface of the flexible wall portion 236 at a location that corresponds to the location where the hammer portion 242 of the trigger spring engages the flexible wall portion.
  • the flexible wall portion 236 is sandwiched between the pressurized gas cannister cap 262 and the hammer portion 242 of the trigger spring 238.
  • the camming hook 158a of spline 156a is positioned at the top of the camming surface 186a of the cam ring 182 and the camming hook 158d of spline 156d is positioned at the top of the camming surface 186d.
  • the camming hooks 158b and 158c (Figs. 6A and 6B) of splines 156b and 156c are in the same position with respect to camming surfaces 186b and 186c (Fig. 8).
  • the hammer portion 242 of the trigger spring is pulled away from the flexible wall portion 236 of the gas expansion chamber housing against the urging of the trigger spring. This occurs until the latch portion 243 of the trigger spring slides out of the first notch 254 of the link 252 so that the deflected hammer portion 242, which is now spaced from the flexible wall portion 236, is released.
  • the released hammer portion 242 due to the resilient forces acting on the deflected trigger spring, impacts the flexible wall portion as the hammer portion springs back to its original position. This forces the central area of the flexible wall portion 236, and thus the puncture tip 264 of Fig. 14B, to move inwards and puncture the seal of the pressurized gas cartridge 204. In doing so, the flexible wall portion elastically deforms in a concave fashion (when viewed from outside of the gas expansion chamber housing 234). As a result, pressurized gas from the gas cartridge fills the gas expansion chamber and flows to the gas tube 222 (Fig. 11 ) via gas passage 212, as described above.
  • the flexible wall may be used to propel the gas cartridge towards a stationary puncture tip to puncture the seal of the pressurized gas cartridge.
  • the shape and volume of the gas expansion chamber 194 (Fig. 10B) are such that the pressure of the gas provided to the gas tube 222 (Fig. 11 ) via gas passage 212, and thus to a vial positioned in the lowered or retracted vial elevator, is less than the pressure of the gas in the gas cartridge 204 (Fig. 14B).
  • the internal cavity 194 acts as a pressure regulator.
  • a tuning post 276 is optionally provided on the passage plate 190 and is engaged by the side of the link 252 as it is pulled by the hook 258 of the cam ring 182 in the manner described above.
  • the tuning post deflects the link 252, which is preferably elastic, as the link moves and thus impacts the release of the latch portion 243 of the trigger spring by notch 254.
  • the positioning of the tuning post 276 may therefore be adjusted to fine tune the release point of the trigger spring hammer portion 242 in relation to the retraction of the vial elevator 148 (and thus a vial positioned therein) into the vial elevator shaft 146.
  • a retainer strap holds the injection device 103 on the transfer device 140 during transportation.
  • the retainer strap 300 remains latched during the transfer of drug from the vial to the injection device 103. Once all of the drug is transferred to the injection device, the retainer strap 300 is released automatically, showing the user that the injection device is ready to be placed on the body.
  • a final venting from the transfer device 140 is performed that releases residual pressure inside the gas expansion chamber 194 (Fig. 10B) that remains after the drug has been completely transferred to the injection device 103.
  • This feature prevents the user from removing the injection device from the transfer base too early. Without the strap, the user may be tempted to remove the injection device before all of the drug has been transferred out of the vial. The mechanism that performs these functions will now be described.
  • the retainer strap 300 includes a first end 301 having a pair of hinge pins 303 and a second end 302 featuring a latching hook 305.
  • the hinge pins 303 are received within a hinge pin receptacle 308 so that the hinge pins 303 are free to rotate therein.
  • the hinge pins may be secured within the hinge pin receptacle in a snap-fit manner.
  • the latching hook of the second end 302 is secured in the latched position illustrated in Figs. 3 and 15 by a pivot plate 308.
  • the pivot plate 308 is pivoted from the position illustrated in Fig. 17 in the direction of arrow 312 (i.e. counterclockwise) during venting of air pressure from the transfer device to release the latching hook 305 (Fig. 16) of the retainer strap 300 so that the injection device may be removed from the transfer device for use.
  • the expansion chamber 194 is provided with a vent housing 320.
  • the vent housing includes a pressure relief or venting bore indicated at 322 in Figs. 10B, 19 and 20.
  • a pressure relief piston assembly is positioned within the vent housing 320 pressure relief bore.
  • the pressure relief piston assembly includes a core, indicated in general at 330 in Fig. 21 , having a head 332 (also shown in Figs. 14A, 18, 23 and 25) and a flange 334.
  • the head 332 includes a pair of ear tabs 336a and 336b, as well as shoulders 338a and 338b and a stop 342.
  • a sealing ring 344 is attached to a bottom portion of the core below flange 334.
  • a compression coil spring 346 is also positioned around the core above the flange 334.
  • the pressure relief piston assembly 324 is attached to the vent housing 320 by inserting the piston assembly head-first through the bottom opening of the bore 322 (visible in Fig. 20) and passing the ear tabs 336a and 336b (Fig. 21 ) up through the corresponding portions of the cross-shaped top opening 348 of the vent housing illustrated in Fig. 19.
  • the compression coil spring 346, the flange 334 and the sealing ring are all positioned within the bore of the vent housing.
  • the pivot plate 308 mentioned previously is pivotally attached to a mounting post 352 positioned next to the vent housing 320.
  • a torsion spring 354 is also positioned upon the mounting post 352 and urges the pivot plate 308 to rotate in the counterclockwise direction (arrow 374 in Fig. 25).
  • the pivot plate includes an arcuate main slot 356 having a stop wall 358, an opposing pair of recesses 362a and 362b and an opposing pair of slots 364a and 364b.
  • the arcuate main slot 356 overlays the top of the vent housing 320 with, as also shown in Fig. 25, the head 332 of the piston assembly positioned within the elongated slot 356 and the arms 336a and 336b of the piston assembly initially positioned within the recesses 362a and 362b of the pivot plate 308 due to the urging of compression coil spring 346 of Fig. 23.
  • the sealing ring 344 is positioned within and closes the venting bore 322 when the pressure relief assembly is in this configuration, which corresponds to the transfer device before the pressurized gas cartridge in the expansion chamber is punctured.
  • the user next inserts and pushes a vial containing liquid mediation into the vial elevator of the transfer device and moves it towards the retracted position so as to activate the transfer device and initiate the transfer of drug from the vial into the injection device.
  • the act of pushing the vial into the system causes the pressurized gas cartridge (204 of Figs. 10B and 14B) to be punctured, thus filling the pressurized gas expansion chamber 194 (Fig. 10B) with pressurized gas.
  • This pressure in the gas expansion chamber pushes on the bottom of the sealing ring 344 (Figs. 10B and 23) which forces the piston assembly to raise in the direction of arrow 372 of Fig. 23 against the urging of the piston assembly compression spring 346.
  • the arms 336a and 336b of the piston assembly rise up out of the recesses 362a and 362b (Fig. 24) of the pivot plate 308.
  • the pivot plate 308 then rotates due to the urging of the torsion spring 354 (Figs. 14A and 18) in the direction of arrow 374 of Fig. 25 until the stop 342 of the piston assembly contacts the stop wall 358 of the pivot plate 308.
  • the sealing ring 344 is still positioned within the venting bore 322 and the venting bore remains closed as the transfer liquid medication from the vial to the injection device occurs.
  • the latching hook of the retainer strap 300 remains in engagement with the pivot plate 308 so that the retainer strap prevents removal of the injection device from the transfer device during the transfer of the liquid medication.
  • the vent filter 208 starts to vent the compressed air from liquid path 214 (Fig. 12) of the transfer device to the atmosphere. This allows the pressure in the expansion chamber 194 (Figs. 10B and 13) to decrease. As the pressure in the expansion chamber decreases, the compression spring 346 (Figs. 14B and 23) begins to expand or extend and, with reference to Fig. 10B, the sealing ring 344 of the pressure relief piston assembly moves downwards within the venting bore 322 of the vent housing 320. A venting notch, indicated at 382 in Figs. 10B and 20, is formed in the vent housing 320.
  • a vial elevator 402, vial elevator shaft 403, cam ring 404 and gas expansion chamber housing 406 of a training transfer device are illustrated.
  • the transfer device of Fig. 26 has been modified to demonstrate proper insertion of a vial into, and resulting fluid flow within and from, the transfer device.
  • a spool valve indicated in general at 416 in Fig. 26, includes a valve housing 422 and a spool 424 that slides within a cylinder 426 formed within the valve housing.
  • a pair of O-ring seals 432a and 432b are provided on the spool 424 so that an annular seal zone or space 425 is formed therebetween.
  • the valve housing 422 has a first bore or port 410 that is in fluid communication with expansion chamber tubing 414 that leads to the interior of the gas expansion chamber housing 406.
  • the valve housing 422 also has a second bore or port 408 which is in fluid communication with vile spike tubing 412 that leads to a boss 413 that has an outlet and is configured to hold a vial spike, such as vial spike 216 of Fig. 11 .
  • a vent opening or port 433 is also formed through the vent housing so that the cylinder 426 is in fluid communication with atmosphere. Any other line or member that provides a fluid passage may be substituted for tubing 412 and 414.
  • a spring return device indicated in general at 428 in Fig. 26, features a housing 432 with a stop pin 434 passing therethrough.
  • a flexible pusher indicated at 436 in Fig. 26, features a first end connected to the cam ring 404 and a second end connected to a spring seat 438.
  • a pusher compression spring 442 is positioned between the spring seat 438 and the spool 424 of the spool valve.
  • the flexible pusher may be constructed from a strip of flexible metal or plastic, or any other semi-rigid material.
  • the compression spring 442 is illustrated as a coil spring, it may alternatively be any elastically compressible member made out of a material such as, but not limited to, rubber.
  • a spool line 444 such as a mono filament line, similarly features a first end connected to the cam ring 404 and a second end connected to the spool.
  • the cam ring rotates clockwise (as indicated by arrow 446 of Fig. 26)
  • the spool line 444 is pulled taut so that the spool 424, and thus the compression spring 442 and the spring seat 438, are pulled away from the spring return device 428.
  • any kind of string, line or filament may be used as the spool line 444 in place of mono filament line 444.
  • a cam ring spring urges the cam ring 404 into the position illustrated in Figs. 26, 27A and 27B, so as to oppose the rotation of the cam ring 404 in the counterclockwise direction of arrow 433.
  • the cam ring spring 448 is illustrated as a coil tension spring, the spring may alternatively take a different form, such as, but not limited to, a rubber band or a compression spring.
  • FIG. 27 A the gas expansion chamber 450 of the gas expansion chamber housing (406 of Fig. 26) is not pressurized, and a vial has not yet been inserted into the vial elevator 402.
  • the elevator remains in the upwards starting position illustrated in Fig. 26.
  • the spool 424 is positioned so that the annular seal zone 425 is in fluid communication with the gas expansion chamber 450 via line 414.
  • the interior of the spring return device 428 is visible in Fig. 27A and features a spring return device cylinder 452 that is in fluid communication with the gas expansion chamber 450 via a port 454.
  • a spring return device piston 456 is slidably received within the cylinder 452 and is connected to the stop pin 434.
  • the stop pin 434 is in the retracted position in Fig. 27A.
  • the gas expansion chamber 450 has been pressurized.
  • the pressure level may be 60 psi. This may be accomplished by providing a wall of the gas expansion chamber housing with a port that is in fluid communication with the outlet of a valve 458.
  • the inlet of the valve 458 may be placed in fluid communication with a source of pressurized air.
  • Alternative arrangements known in the art may instead be used to pressurize the gas expansion chamber 450.
  • the valve 458 may be a check valve or manually operated 2-way valve.
  • the vial elevator engages the camming surfaces of the cam ring 404 and the cam ring rotates counterclockwise about the vial elevator shaft 403, as illustrated by arrow 433, against the urging of tension spring 448. This causes the flexible pusher 436 to move in the direction of arrow 436 while the mono filament line 444 goes slack.
  • the user holds the inverted vial down so that the vial elevator 402 is in the lowered position against the urging of the cam ring 404 and expanded expansion spring 448.
  • the user With reference to Fig. 27E, upon completion of the simulated transfer described above with reference to Figs. 27A-27D, the user removes the inverted vial from the vial elevator 402 so that the vial elevator is free to be returned to the initial raised position (illustrated in Fig. 26) as the spring 448 contracts and pulls the cam ring 404 in the clockwise direction illustrated by arrow 466. As this occurs, the end of the mono filament line 444 attached to the cam ring is pulled in the direction of arrow 466 so that the spool 424 is pulled to the initial position illustrated in Fig. 27E (and Figs. 26, 27A and 27B).
  • a training vial suitable for use with the training transfer device of Figs. 26-27E is indicated in general at 502 of Figs. 28A-28B.
  • the training vial 502 is configured so that, when inverted, it simulates liquid medicine or injectable leaving the vial, and thus the liquid level within the vial decreasing, such as during transfer of the liquid medicine or injectable into an injection device.
  • the training vial 502 includes an annular fluid passage 506 formed within the sidewall 508, end 510 and neck region 512 of the training vial. As a result, when the fluid passage 506 is filled with liquid, the vial appears to be full. The fluid passage 506 may optionally be omitted from the end 510 of the training vial.
  • the training vial further includes a cap 514 that houses a fluid chamber 516. Cap fluid chamber 516 features one or more flow openings in fluid communication with the fluid passage 506.
  • the training vial 502 also includes a hollow space 524 that is not in fluid communication with the fluid passage 506 or the cap fluid chamber 516 and contains only air.
  • the training vial 502 when the training vial 502 is inverted, and all of the liquid has flowed from the fluid passage 506 of the training vial to the cap fluid chamber 516, the training vial appears to be empty, such as at the completion of injectable transfer to an injection device.
  • the training vial 502 may be reset for reuse simply by returning it to the upright position illustrated in Fig. 28A so that liquid within the cap fluid chamber 516 flows back into the fluid passage 506.
  • FIGs. 29A and 29B demonstration of the flow of injectable from a vial 602 through a passage 603 of a transfer device 604 to an injection device 606 may be accomplished by providing a syringe cylinder 608 within the bottom of the elevator shaft 612 of a vial holder 614.
  • the syringe cylinder 608 is provided with a syringe piston 616.
  • Liquid 618 simulating injectable is initially within the syringe cylinder 608 below the syringe piston 616.
  • a vial elevator (not shown) is slidably received within the elevator shaft 612 and receives inverted vial 602.
  • the inverted vial 602 is then moved from an initial raised position, illustrated in Fig. 29A to the lowered position illustrated in Fig. 29B by pushing down on the vial as illustrated by arrow 622 of Fig. 29A.
  • transfer of liquid from the vial to the injection device is accomplished without use of a pressurized gas source and without breaching a vial.
  • Fig. 30 Components of a training transfer device for simulating activation of a trigger spring to puncture a pressurized gas canister, described with reference to Figs. 14A and 14B above, are presented in Fig. 30.
  • the components of Fig. 30 may be combined with the components of Fig. 26 in a single training transfer device.
  • the training transfer device includes a vial elevator 702, vial elevator shaft 703, cam ring 704 and a gas expansion chamber housing 706.
  • the training transfer device also includes a clicker rod assembly, indicated in general at 708 in Fig. 30.
  • a pushing member 712 is secured to the cam ring 704 and includes a pushing surface 714 and a receiving notch 716.
  • a clicker rod housing 720 includes a cylinder 722 within which a compression spring 724 is positioned. While the compression spring is illustrated as a coil spring, the compression spring 724 is illustrated as a coil spring, it may alternatively be any elastically compressible member made out of a material such as, but not limited to, rubber.
  • an opening 734 is formed within the housing 720 and is surrounded by a stop surface 736 which defines one end of the cylinder.
  • the opening 734 is sized so that the plunger 732 of the clicker rod cannot exit the cylinder 722 and instead engages the stop surface 736.
  • the compression spring 724 urges the plunger 732 of the clicker rod into the position illustrated in Fig. 30 and 31 A.
  • a spring such as such as spring 448 of Fig. 27A, urges the cam ring 704 into the position shown in Figs. 30 and 31 A.
  • an inverted vial is inserted into the vial elevator 702 and pressed downwards.
  • the vial elevator engages the camming surfaces of the cam ring 704 and the cam ring rotates counterclockwise about the vial shaft elevator 703, as illustrated by arrow 742 of Fig. 31 B.
  • the pushing surface 714 pushes the contact end 731 of the clicker rod 726 so that it moves in the direction of arrow 744.
  • the movement of the clicker rod 726 in the direction of arrow 744 moves the plunger portion in the same direction so that spring 724 is compressed.
  • a slot 752 is formed in the housing 720 so that the flexible shaft portion 730 of the clicker rod is free to flex out of the way to permit passage of the pushing member 712 as it moves back to its starting position.
  • the components of Fig. 30 may be combined with the components of Fig. 26 in a single training transfer device.
  • the clicker rod housing 720 of Fig. 30 could be positioned on top of the spool valve housing 422 of Fig. 26 with the flexible pusher 436 and the mono filament line 444 connected to the pushing member 712, as illustrated in Fig. 26.
  • the present subject matter is described herein with reference to specific structures, methods and examples, this is for purposes of illustration only, and it is understood that the present subject matter is applicable to a large range of devices and systems that may differ in particular configuration and appearance while still employing this subject matter.

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Abstract

Des versions d'entraînement de dispositifs pour transférer un médicament d'un flacon à un dispositif médical comprennent des fonctionnalités qui permettent un fonctionnement simulé des dispositifs de transfert tout en permettant leur réinitialisation pour une utilisation ultérieure après une session de formation ou de démonstration.
PCT/US2025/025931 2024-04-24 2025-04-23 Dispositif d'entraînement de dispositif de transfert alimenté au gaz Pending WO2025226792A1 (fr)

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US63/637,968 2024-04-24

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130110049A1 (en) * 2010-05-20 2013-05-02 Becton, Dickinson And Company Drug delivery device
WO2015110327A1 (fr) * 2014-01-21 2015-07-30 Carebay Europe Ltd Dispositif de formation pour realiser une injection
US9925333B2 (en) * 2013-06-18 2018-03-27 Enable Injections, Inc. Vial transfer and injection apparatus and method
US10795973B2 (en) * 2014-10-03 2020-10-06 Noble International, Inc. Medicament training device and system
WO2021260007A1 (fr) * 2020-06-25 2021-12-30 Sanofi Dispositif, système et procédé d'entraînement
WO2022031784A1 (fr) * 2020-08-04 2022-02-10 Enable Injections, Inc. Dispositif et système de transfert de liquide alimenté par gaz sous pression

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130110049A1 (en) * 2010-05-20 2013-05-02 Becton, Dickinson And Company Drug delivery device
US9925333B2 (en) * 2013-06-18 2018-03-27 Enable Injections, Inc. Vial transfer and injection apparatus and method
WO2015110327A1 (fr) * 2014-01-21 2015-07-30 Carebay Europe Ltd Dispositif de formation pour realiser une injection
US10795973B2 (en) * 2014-10-03 2020-10-06 Noble International, Inc. Medicament training device and system
WO2021260007A1 (fr) * 2020-06-25 2021-12-30 Sanofi Dispositif, système et procédé d'entraînement
WO2022031784A1 (fr) * 2020-08-04 2022-02-10 Enable Injections, Inc. Dispositif et système de transfert de liquide alimenté par gaz sous pression

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