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WO2025224076A1 - Substituted arylpyrazines and salts thereof, and use thereof as herbicides - Google Patents

Substituted arylpyrazines and salts thereof, and use thereof as herbicides

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Publication number
WO2025224076A1
WO2025224076A1 PCT/EP2025/060881 EP2025060881W WO2025224076A1 WO 2025224076 A1 WO2025224076 A1 WO 2025224076A1 EP 2025060881 W EP2025060881 W EP 2025060881W WO 2025224076 A1 WO2025224076 A1 WO 2025224076A1
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Prior art keywords
alkyl
phenyl
aryl
chloro
cycloalkyl
Prior art date
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Pending
Application number
PCT/EP2025/060881
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German (de)
French (fr)
Inventor
Hartmut Ahrens
Arnim Köhn
Jens Frackenpohl
Maud BOLLENBACH
Ralf Braun
Thomas Müller
David Michael BARBER
Birgit BOLLENBACH-WAHL
Dirk Schmutzler
Anna Maria REINGRUBER
Marc LINKA
Manuel SOMMER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
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Publication of WO2025224076A1 publication Critical patent/WO2025224076A1/en
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P13/00—Herbicides; Algicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Definitions

  • the invention relates to the technical field of plant protection products, in particular herbicides for the selective control of weeds and grasses in crops. 10 Specifically, this invention relates to substituted arylpyrazines and their salts, processes for their production, and their use as herbicides, in particular for controlling weeds and/or grasses in crops and/or as plant growth regulators to influence the growth of crops. 15.
  • Previously known plant protection products for the selective control of weeds in crops or active ingredients for controlling unwanted plant growth have some disadvantages in their application, be it that they (a) have no or insufficient herbicidal activity against certain weeds, (b) have too narrow a spectrum of weeds that can be controlled with one active ingredient, (c) have insufficient selectivity in crops 20, and/or (d) have an unfavorable toxicological profile.
  • active ingredients that can be used as plant growth regulators in some crops lead to undesirably reduced yields in other crops or are not compatible with the crop or only within a narrow application rate range.
  • Some of the known active ingredients cannot be produced economically on an industrial scale 25 due to difficult-to-access precursors and reagents or have insufficient chemical stability.
  • heteroaryltriazoles and heteroaryltetrazoles as well as their insecticidal activity when applied to crops, have also been described (see WO 2019/201835, WO 2019/197468, WO 2019/202077, WO 2019/206799, WO 2023/037249). It is known from various publications that certain substituted heteroaryltriazoles and heteroaryltetrazoles can be used as active ingredients against ectoparasites in animals or against insects to prevent feeding damage in crops. BCS241005-Abroad STR 2 It is also known that certain azolamides can be used as insecticidal active ingredients (WO2020/002563, WO2020/053364, WO2020/053365, WO2020/079198).
  • substituted heteroaryloxazoles and heteroarylthiazoles also exhibit insecticidal effects (see WO2023/110473).
  • substituted heteroarylpyrazines can be used as insecticidal active ingredients (see WO2020/201079; WO2020/208036, WO2020/201398, WO2021/069575, WO2021/068179, WO2022/258481).
  • Substituted N-(arylpyrazinylalkyl)carboxamides with herbicidal activity have not yet been described.
  • substituted arylquinoxalines and their use as PI3 kinase inhibitors have also been described
  • substituted N-(arylpyrazinylalkyl)carboxamides with substituted pyrazinylbenzoic acid groups have not yet been described.
  • certain substituted arylpyrazines or their salts 15 are well suited as herbicides and can be used particularly advantageously as active ingredients for controlling monocotyledonous and dicotyledonous weeds in crops.
  • An object of the present invention is thus substituted arylpyrazines of general formula (I) or their salts, 20 where M is for one of the groups M -1 M-2 M-3 25, where the dashed line marks the link to the rest of formula (I), BCS241005-Abroad STR 3
  • R 1 R stands for aryl or heteroaryl, wherein the aryl or heteroaryl group is optionally further substituted by 1, 2 or 3 independently chosen substituents bonded to ring carbon atoms 4 , and where, if necessary, two adjacent substituents R 4 with the ring carbon atoms to which they are bonded, can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, 10 or R 1 stands for a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group
  • the compounds of general formula (I) can be modified by addition of a suitable inorganic or organic acid, such as mineral acids, for example HCl, HBr, H 2 SO 4 , H 3 PO 4 or ENT 3
  • Organic acids e.g., carboxylic acids such as formic acid, acetic acid, propionic acid, oxalic acid, lactic acid, or salicylic acid, or sulfonic acids such as p-toluenesulfonic acid, react with a basic group, such as an amino, alkylamino, dialkylamino, piperidino, morpholino, or pyridino, to form salts.
  • a basic group such as an amino, alkylamino, dialkylamino, piperidino, morpholino, or pyridino
  • Suitable substituents that exist in deprotonated form can form internal salts with their own protonatable groups, such as amino groups. Salt formation can also occur through the action of a base on compounds of the general formula (I).
  • Suitable bases include, for example, organic amines such as trialkylamines, morpholine, piperidine, and pyridine, as well as ammonium, alkali, or alkaline earth metal hydroxides, carbonates, and bicarbonates, in particular sodium and potassium hydroxide, sodium and potassium carbonate, and sodium and potassium bicarbonate.
  • salts are compounds in which the acidic hydrogen is replaced by a cation suitable for agriculture, for example, metal salts, in particular alkali metal salts or alkaline earth metal salts, in particular sodium and potassium salts, or also ammonium salts, salts with organic amines, or quaternary ammonium salts, for example, with cations of the formula [NR a R b R c R d ] + , in which R a to R d Each independently represents an organic residue, in particular alkyl, aryl, aralkyl, or alkylaryl.
  • Alkylsulfonium and alkylsulfoxonium salts such as (C 1 -C 4 )-Trialkylsulfonium- and (C 1 -C 4 )-Trialkylsulfoxonium salts.
  • the compounds of general formula (I) can exist as stereoisomers depending on the type and combination of the substituents.
  • the possible stereoisomers defined by their specific spatial shape, BCS241005-Abroad STR 8, such as enantiomers, diastereomers, Z- and E-isomers, are all encompassed by formula (I). For example, if one or more alkenyl groups are present, diastereomers (Z- and E-isomers) can occur.
  • Stereoisomers can be obtained from the mixtures obtained during step 5 of the preparation using standard separation methods. Chromatographic separation can be performed both on an analytical scale to determine the enantiomeric or diastereomeric excess, and on a preparative scale to prepare test samples for biological testing. Stereoisomers can also be selectively prepared by using stereoselective reactions with optically active starting materials and/or excipients. The invention thus also relates to all stereoisomers encompassed by the general formula (I) but not specified with their specific stereoform, as well as their mixtures.
  • Separated enantiomers encompassed by the general formula (I) are either (a) designated according to their optical activity with (+)- and (-), i.e., isomers that rotate plane-polarized light clockwise ((+)-direction) are designated with "(+)” 15; (b) classified into R- and S-enantiomers according to the Cahn-Ingold-Prelog rules; or (c) designated according to their retention time upon separation by chiral chromatography with "Ent-1" and "Ent-2".
  • Methods for separating enantiomers are well known in the prior art, e.g., separation by chiral chromatography. 20 If the compounds are obtained as solids, purification can also be carried out by recrystallization or digestion.
  • Individual compounds (I) can also be prepared by derivatizing other compounds (I). Methods generally known to those skilled in the art from analogous cases are suitable for isolating, purifying, and separating the stereoisomers of compounds of formula 25 (I). These methods include physical processes such as crystallization, chromatographic processes, especially column chromatography and HPLC (high-performance liquid chromatography), distillation, optionally under reduced pressure, extraction, and other processes. Any remaining mixtures can generally be separated by chromatographic separation, e.g., on chiral solid phases.
  • Preferred subject matter of the invention is compounds of the general formula (I), wherein M represents one of the groups M -1 M-2 M-3 5, where the dashed line marks the link to the rest of formula (I), R 1 for aryl or heteroaryl, 10 wherein the aryl or heteroaryl group is optionally further substituted by 1, 2 or 3 substituents bonded to ring carbon atoms and chosen independently of one another R 4 , and where, if necessary, two adjacent substituents R 4 with the ring carbon atoms to which they are bonded, they can form a saturated, partially saturated or 15 unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, or R 1 represents a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, 20 wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen and sulfur, and where
  • Particularly preferred subject matter of the invention is compounds of the general formula (I), wherein M represents the groups M -1 M-2 M-3 25, where the dashed line marks the link to the rest of formula (I), R 1 for aryl or heteroaryl, 30 wherein the aryl or heteroaryl group is optionally further substituted by 1, 2 or 3 substituents bonded to ring carbon atoms and chosen independently of one another R 4 , BCS241005-Abroad STR 14 and where, if applicable, two adjacent substituents R 4 with the ring carbon atoms to which they are bonded, can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, 5 or R 1 stands for a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen and sulfur, and wherein
  • R 8 for hydrogen, (C 1 -C 6 )-Alkyl, (C 1 -C 6 )-Haloalkyl, Aryl, Aryl-(C 1 -C 6 )-alkyl, heteroaryl, (C 2 -C 6 )-Alkynyl, (C 2 -C 6 )-Alkenyl, C(O)R 13 , C(O)OR 13 , (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkyl stands, 15 R 9 for hydrogen or (C 1 -C 6 )-Alkyl stands, R 10 for hydrogen, halogen, cyano, NO 2 , (C 1 -C 6 )-Alkyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )-Cycloalkyl-(C 1
  • Particularly preferred subject matter of the invention is compounds of the general formula (I), wherein M represents the groups BCS241005-Abroad STR 18 ⁇ M -1 M-2 M-3 stands, where the dashed line marks the point of connection to the rest of formula (I), 5 R 1 R stands for aryl or heteroaryl, wherein the aryl or heteroaryl group may be further substituted by 1, 2 or 3 independently chosen substituents bonded to ring carbon atoms 4 , 10 and where, if applicable, two adjacent substituents R 4 with the ring carbon atoms to which they are bonded, can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, 15 or R 1 stands for a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen and sulfur, and
  • Q -1 Q-2 stands 25 R 8 for hydrogen, (C 1 -C 6 )-Alkyl, (C 1 -C 6 )-Haloalkyl, Aryl, Aryl-(C 1 -C 6 )-alkyl, heteroaryl, (C 2 -C 6 )-Alkynyl, (C 2 -C 6 )-Alkenyl, C(O)R 13 , C(O)OR 13 , (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkyl stands, R 9 for hydrogen or (C 1 -C 6 )-Alkyl stands, 30 R 10 for hydrogen, halogen, cyano, NO 2 , (C 1 -C 6 )-Alkyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )-Cycloalkyl-(C
  • BCS241005-Abroad STR 20 Cyano-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkylcarbonyloxy-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkyl- carbonyloxy-(C 1 -C 6 )-alkyl, arylcarbonyloxy-(C 1 -C 6 )-alkyl, heteroarylcarbonyloxy-(C 1 -C 6 )-alkyl, heterocyclylcarbonyloxy-(C 1 -C 6 )-alkyl, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO 2 R 14 , R 14 S-(C 1 - C 6 )-alkyl, R 14 (O)S-(C 1 -C 6 )-alkyl, R 14 O 2 S-(C 1 -C 6 )-alkyl,
  • the preferred subject matter of the invention is compounds of the general formula (I), wherein M stands for the groups M -1 M-2 M-3 10, where the dashed line marks the link to the rest of formula (I), R 1 for phenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2-trifluoromethylphenyl, 3-15 trifluoromethylphenyl, 4-trifluoromethylphenyl, 2-trifluoromethoxyphenyl, 3-trifluoromethoxyphenyl, 4-trifluoromethoxyphenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 3-fluorophenyl, 4-fluorophenyl, 2-fluorophenyl, 2-bromophenyl, 2-iodophenyl, 3-bromophenyl, 3-iodophenyl, 4-bromophenyl, 4-iodophenyl, 2-difluoromethylphenyl, 2-cyanoph
  • alkyl In a compound chemical group such as heterocyclyl-25 (C 1 -C 8 )-alkyl or R 13 O(O)C-(C 1 -C 8 )-Alkyl, the term “alkyl” therefore also stands for an alkylene group.
  • the connection to the framework or the rest of the molecule occurs via the first-mentioned structural element of the relevant chemical group.
  • alkylsulfonyl either alone or as part of a chemical group – represents straight-chain or branched alkylsulfonyl, preferably with 1 to 8, or with 1 to 6 carbon atoms, e.g.
  • (but not limited to) (C 1 -C 6 )-alkylsulfonyl such as methylsulfonyl, ethylsulfonyl, propylsulfonyl, 1-methylethylsulfonyl, butylsulfonyl, 1-methylpropylsulfonyl, 2-methylpropylsulfonyl, 1,1-dimethylethylsulfonyl, pentylsulfonyl, 1-methylbutylsulfonyl, 2-Methylbutyl-35sulfonyl, 3-Methylbutylsulfonyl, 1,1-Dimethylpropylsulfonyl, 1,2-Dimethylpropylsulfonyl, 2,2-Di-methylpropylsulfonyl, 1-Ethylpropylsulfonyl, Hexylsulfonyl, 1-Methy
  • heteroarylsulfonyl means optionally substituted pyridylsulfonyl, pyrimidinylsulfonyl, pyrazinylsulfonyl, or optionally substituted polycyclic heteroarylsulfonyl, in particular optionally substituted quinolinylsulfonyl, for example substituted by fluorine, chlorine, bromine, iodine, cyano, nitro, alkyl, haloalkyl, haloalkoxy, amino, alkylamino, alkylcarbonylamino, dialkylamino, or alkoxy groups.
  • alkylthio means—alone or as part of a chemical group—straight-chain or branched S-alkyl, preferably with 1 to 8, or with 1 to 6 carbon atoms, such as (C 1 -C 10 )-, (C 1 -C 6 )- or (C 1 -C 4 )-Alkylthio, e.g.
  • alkenylthio means an alkenyl group bonded via a sulfur atom
  • alkynylthio means an alkynyl group bonded via a sulfur atom
  • cycloalkylthio means a cycloalkyl group bonded via a sulfur atom
  • cycloalkenylthio means a cycloalkenyl group bonded via a sulfur atom
  • (but not limited to) (C 1 -C 6 )-Alkylsulfinyl such as methylsulfinyl, ethylsulfinyl, propylsulfinyl, 1-methylethylsulfinyl, butylsulfinyl, 1-methylpropylsulfinyl, 2-methylpropylsulfinyl, 1,1-dimethylethylsulfinyl, pentylsulfinyl, 1-methylbutylsulfinyl, 2-Methylbutylsulfinyl, 3-Methylbutylsulfinyl, 1,1-Dimethylpropylsulfinyl, 1,2-Dimethylpropylsulfinyl, 2,2-Di-methylpropylsulfinyl, 1-Ethylpropylsulfinyl, Hexylsulfinyl, 1-Methyl
  • Alkoxy means an alkyl group bonded via an oxygen atom, e.g.
  • Alkenyloxy means an alkenyl group bonded via an oxygen atom
  • alkynyloxy means an alkynyl group bonded via an oxygen atom, such as (C 2 -C 10 )-, (C 2 -C 6 )- or (C 2 -C 4 )-Alkenoxy or (C 3 -C 10 )-, (C 3 -C 6 )- or (C 3 -C 4 )-Alkyneoxy.
  • Cycloalkyloxy means a cycloalkyl group bonded via an oxygen atom
  • cycloalkenyloxy means a cycloalkenyl group bonded via an oxygen atom.
  • the number of C atoms refers to the alkyl group in the alkyl carbonyl group.
  • the number of carbon atoms refers to the alkenyl or alkynyl residue in the 35-alkenyl or alkynyl carbonyl group, respectively.
  • Alkynyl carbonyl is the 35-carbon group.
  • the number of C atoms refers to the alkyl group in the alkoxycarbonyl group.
  • the number of carbon atoms refers to the alkyl group in the alkylcarbonyloxy group.
  • the number of carbon atoms refers to the alkenyl or alkynyl residue in the alkenyl or alkynylcarbonyloxy group.
  • 20 In short forms such as C(O)R 13 , C(O)OR 13 , OC(O)NR 11 R 12 , or C(O)NR 11 R 12
  • the abbreviation O shown in parentheses represents an oxygen atom bonded to the adjacent carbon atom via a double bond.
  • 25 In abbreviations such as OC(S)OR 13 , OC(S)SR 14 , OC(S)NR 11 R 12
  • the abbreviation S in parentheses represents a sulfur atom bonded to the adjacent carbon atom via a double bond.
  • aryl means an optionally substituted mono-, bi-, or polycyclic aromatic system with preferably 6 to 14, in particular 6 to 10 ring carbon atoms, for example phenyl, naphthyl, anthryl, phenanthrenyl, and the like, preferably phenyl or naphthyl, and in particular preferably phenyl.
  • optionally substituted aryl also includes multicyclic systems such as tetrahydronaphtyl, indenyl, indanyl, fluorenyl, and biphenylyl, where the bonding site is on the aromatic system.
  • aryl is generally also encompassed by the term “optionally substituted phenyl.”
  • Preferred aryl substituents are, for example, BCS241005-Ausland STR 50 hydrogen, halogen, alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, halocycloalkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkoxyalkyl, alkylthio, haloalkylthio, haloalkyl, Alkoxy, haloalkoxy, cycloalkoxy, cycloalkylalkoxy, aryloxy, heteroraryloxy, alkoxyalkoxy, alkynylalkoxy, alkenyloxy, bis-alkylaminoalkoxy, tris
  • multicyclic systems are also included, such as 8-aza-bicyclo[3.2.1]octanyl, 8-aza-bicyclo[2.2.2]octanyl, or 1-aza-bicyclo[2.2.1]heptyl.
  • spirocyclic systems are also included, such as 1-oxa-5-aza-spiro[2.3]hexyl.
  • the heterocyclic ring preferably contains 3 to 9 ring atoms, in particular 3 to 6 ring atoms, and one or more, 25 preferably 1 to 4, in particular 1, 2 or 3 heteroatoms in the heterocyclic ring, preferably from the group N, O, and S, wherein, however, no two oxygen atoms should be directly adjacent, such as with a heteroatom from the group N, O and S 1- or 2- or 3-pyrrolidinyl, 3,4-dihydro-2H-pyrrole-2- or 3-yl, 2,3-dihydro-1H-pyrrole-1- or 2- or 3- or 4- or 5-yl; 2,5-dihydro-1H-pyrrole-1- or 2- or 3- or 3-yl, 1- or 2- or 3- or 4-piperidinyl; 2,3,4,5-30 Tetrahydropyridin-2-, 3-, 4-, or 5-yl or 6-yl; 1,2,3,6-Tetrahydropyridin-1-, 2-, 3-, 4-, 5-, or 6-yl
  • Preferred 3-ring and 4-ring heterocycles are, for example, 1- or 2-aziridinyl, oxiranyl, thiiranyl, 1- or 2- or 3-acetidinyl, 2- or 3-oxetanyl, 2- or 3-thietanyl, and 1,3-dioxetan-2-yl.
  • heterocyclyl are a partially or fully hydrogenated heterocyclic residue with two heteroatoms from the group N, O, and S, such as 1- or 2- or 3- or 4-pyrazolidinyl; 4,5-dihydro-3H-pyrazole-3- or 4- or 5-yl; and 4,5-dihydro-1H-pyrazole-1- or 3- or 4- or 5-yl.
  • heterocyclyl are a partially or fully hydrogenated heterocyclic residue with 3 heteroatoms from the group N, O, and S, such as 1,4,2-dioxazolidin-2-, 3-, or 5-yl; 1,4,2-dioxazol-3- or 5-yl; 1,4,2-dioxazinan-2-, 3-, 5-, or 6-yl; 5,6-dihydro-1,4,2-dioxazin-3-, 5-, or 6-yl; 1,4,2-dioxazin-3-, 5-, or 6-yl; 1,4,2-dioxazepane-2-, 3-, 5-, 6-, or 7-yl; 6,7-Dihydro-5H-1,4,2-dioxazepine-3-, 5-, 6-, or 7-yl; 2,3-Dihydro-7H-1,4,2-25-dioxazepine-2-, 3-, 5-, 6-, or 7-yl; 2,3-Dihydro-5H-1,4,2-25-diox
  • BCS241005-Abroad STR 54 BCS241005-Abroad STR 55 ⁇
  • the heterocycles listed above are preferably, for example, hydrogen, halogen, alkyl, haloalkyl, hydroxy, alkoxy, cycloalkoxy, aryloxy, alkoxyalkyl, alkoxyalkoxy, cycloalkyl, halocycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclyl, alkenyl, alkylcarbonyl, cycloalkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, Alkoxycarbonyl, hydroxycarbonyl, cycloalkoxycarbonyl, cycloalkylalkoxycarbonyl, alkoxycarbonylalkyl, arylalkoxycarbonyl, arylalkoxycarbonylalkyl, alkynyl, alkynyl, alkynyl
  • the substituents listed below are suitable for a substituted heterocyclic residue, as are oxo and thioxo.
  • the "oxo group” as a substituent on a ring carbon atom then means, for example, a carbonyl group in the heterocyclic ring. This preferably also includes lactones and lactams.
  • the oxo group can also occur on the 20 heteroring atoms, which can exist in different oxidation states, e.g., on N and S, and then form, for example, the divalent groups N(O) , S(O) (also abbreviated SO) and S(O) . 2 (also abbreviated SO) 2 ) in the heterocyclic ring.
  • N(O) , S(O) also abbreviated SO
  • S(O) . 2 also abbreviated SO 2
  • heteroaryl stands for heteroaromatic compounds, i.e., completely unsaturated aromatic heterocyclic compounds, preferably for 5- to 7-membered rings with 1 to 4, preferably 1 or 2 identical or different heteroatoms, preferably O, S, or N.
  • Heteroaryls according to the invention are, for example, 1H-pyrrol-1-yl; 1H-pyrrol-2-yl; 1H-pyrrol-3-yl; furan-2-yl; furan-3-yl; thien-2-yl; thien-3-yl; 1H-imidazol-1-yl; 1H-imidazol-2-yl; 1H-imidazol-304-yl; 1H-imidazol-5-yl; 1H-pyrazol-1-yl; 1H-pyrazol-3-yl; 1H-pyrazol-4-yl; 1H-pyrazol-5-yl, 1H-1,2,3-triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1
  • heteroaryl groups according to the invention can further be substituted with one or more identical or different substituents. If two adjacent carbon atoms are part of another aromatic ring, the resulting systems are fused heteroaromatics, such as benzo-condensed or multiply fused heteroaromatics.
  • quinolines e.g., quinoline-2-yl, quinoline-3-yl, quinoline-4-yl, quinoline-5-yl, quinoline-6-yl, quinoline-7-yl, quinoline-8-yl
  • isoquinolines e.g., isoquinoline-1-yl, isoquinoline-3-yl, isoquinoline-4-yl, isoquinoline-5-yl, isoquinoline-6-yl, isoquinoline-7-yl, isoquinoline-8-yl
  • quinoxaline quinazoline
  • cinnoline 1,5-naphthyridine; 1,6-naphthyridine; 1,7-naphthyridine; 1,8-naphthyridine; 2,6-naphthyridine; 2,7-naphthyridine; phthalazine; pyridopyrazines; pyridopyrimidines;
  • heteroaryls also include 5- or 6-membered benzo-condensed rings from the group 1H-indol-1-yl, 1H-indol-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol-5-yl, 1H-15-indol-6-yl, 1H-indol-7-yl, 1-benzofuran-2-yl, 1-benzofuran-3-yl, 1-benzofuran-4-yl, 1-benzofuran-5-yl, 1-benzofuran-6-yl, 1-benzofuran-7-yl, 1-benzothiophen-2-yl, 1-benzothiophen-3-yl, 1-benzothiophen-4-yl, 1-benzothiophen-5-yl, 1-benzothiophen-6-yl, 1-Benzothiophen-7-yl, 1H-Indazol-1-yl, 1H-Indazol-3
  • halogen means, for example, fluorine, chlorine, bromine, or iodine. If the designation is used for a residue, then "halogen” means, for example, a fluorine, chlorine, bromine, or iodine atom.
  • alkyl means a straight-chain or branched open-chain saturated hydrocarbon residue, which is optionally one- or multiple-substituted and, in the latter case, is referred to as "substituted alkyl".
  • Preferred substituents are halogen atoms, alkoxy, haloalkoxy, cyano, alkylthio, haloalkylthio, amino, or nitro groups; methoxy, methyl, fluoroalkyl, cyano, nitro, fluorine, chlorine, bromine, or iodine are particularly preferred.
  • the prefix "bis" indicates... BCS241005-Abroad STR 58 also includes the combination of different alkyl groups, e.g., methyl(ethyl) or ethyl(methyl). Alkyl groups can have different names for the same group depending on the notation used, but these are generally accepted in the field.
  • alkenyl alkynyl
  • monohaloalkyl monohaloalkyl
  • Perhaloalkyl such as CCl 3, CClF 2, CFCl 2 ,CF 2 CClF 2, CF 2 CClFCF 3 ; Polyhaloalkyl such as CH 2 CHFCl, CF 2 CClFH, 10 CF 2 CBrFH, CH 2 CF 3
  • perhaloalkyl also includes the term perfluoroalkyl.
  • Haloalkoxy is, for example, OCF.
  • (C 1 -C 4 )-Alkyl is a shorthand notation for straight-chain or branched alkyl with one to four carbon atoms, depending on the specified range for carbon atoms, i.e., it includes the groups methyl, ethyl, 1-propyl, 2-propyl, 1-butyl, 2-butyl, 2-methylpropyl, or tert-butyl.
  • alkyl groups with a larger specified range of carbon atoms e.g., "(C 1 -C 6
  • alkyl also includes straight-chain or branched alkyl groups with a larger number of carbon atoms, i.e., as in the example, also alkyl groups with 5 and 6 carbon atoms.
  • hydrocarbon groups such as alkyl, alkenyl, and alkynyl groups, including those in compound groups, the lower carbon skeletons are preferred, e.g., with 1 to 6 carbon atoms or, in the case of unsaturated groups, with 2 to 6 carbon atoms.
  • Alkyl groups including those in compound groups such as alkoxy, haloalkyl, etc., include, for example, methyl, ethyl, n- or i-propyl, n-, i-, t-, or 2-butyl, pentyls, hexyls such as n-hexyl, i-hexyl, and 1,3-dimethylbutyl, and heptyls such as... n-Heptyl, 1-methylhexyl, and 1,4-dimethylpentyl; alkenyl and alkynyl groups have the meaning of the possible unsaturated groups corresponding to the alkyl groups, containing at least one double bond 30 or triple bond, respectively.
  • alkenyl also includes, in particular, straight-chain or branched open-chain hydrocarbon groups with more than one double bond, such as 1,3-butadienyl and 1,4-pentadienyl, 35 but also allenyl or cumulenyl groups with one or more cumulated double bonds, such as allenyl (1,2-propadienyl), 1,2-butadienyl, and 1,2,3-pentatrienyl.
  • Alkenyl means, for example, vinyl, which may optionally be substituted by further alkyl groups, e.g.
  • alkynyl also includes, in particular, straight-chain or branched open-chain hydrocarbon residues with more than one triple bond or with one or more triple bonds and one or more double bonds, such as 1,3-butatrienyl or 3-penten-1-yne-1-yl.
  • (C 2 -C 6 )-Alkynyl means, for example, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-Methyl-3-25pentynyl, 1-Methyl-4-pentynyl, 2-Met
  • cycloalkyl means a carbocyclic saturated ring system with preferably 3-8 ring carbon atoms, e.g., cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, which is optionally further substituted, preferably by hydrogen, alkyl, alkoxy, oxo, cyano, nitro, alkylthio, haloalkylthio, halogen, alkenyl, alkynyl, haloalkyl, amino, alkylamino, bisalkylamino, alkoxycarbonyl, hydroxycarbonyl, arylalkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, 35 cycloalkylaminocarbonyl.
  • cyclic systems with substituents are included, wherein substituents with a double bond on the cycloalkyl group, e.g., an alkylidene group such as methylidene, are also included.
  • substituted cycloalkyl also includes multicyclic aliphatic systems, such as bicyclo[1.1.0]butan-1-yl, bicyclo[1.1.0]butan-2-yl, bicyclo[2.1.0]pentan-1-yl, bicyclo[1.1.1]pentan-1-yl, bicyclo[2.1.0]pentan-2-yl, bicyclo[2.1.0]pentan-5-yl, bicyclo[2.1.1]hexyl, bicyclo[2.2.1]hept-2-yl, bicyclo[2.2.2]octan-2-yl, bicyclo[3.2.1]octan-2-yl, bicyclo[3.2.2]nonan-2-yl, adamantan-1-yl and 5 adamantan-2-yl, but also systems such as...
  • spirocyclic aliphatic systems are also included, such as, for example, Spiro[2.2]pent-1-yl, Spiro[2.3]hex-1-yl, Spiro[2.3]hex-4-yl, 3-Spiro[2.3]hex-5-yl, Spiro[3.3]hept-1-yl, Spiro[3.3]hept-2-yl.
  • Cycloalkenyl means a carbocyclic, non-aromatic, partially unsaturated ring system with preferably four to eight carbon atoms, e.g., 1-cyclobutenyl, 2-cyclobutenyl, 1-cyclopentenyl, 2-cyclopentenyl, 15 3-Cyclopentenyl, or 1-cyclohexenyl, 2-cyclohexenyl, 3-cyclohexenyl, 1,3-cyclohexadienyl, or 1,4-cyclohexadienyl, including substituents with a double bond on the cycloalkenyl residue, e.g., an alkylidene group such as methylidene.
  • alkylidene e.g., also in the form (C 1 -C 10 )-Alkylidene refers to the residue of a straight-chain or branched open-chain hydrocarbon group that is bonded via a double bond.
  • Cycloalkylidene means a 25 carbocyclic group bonded via a double bond.
  • Cycloalkylalkyloxy means a cycloalkylalkyl group bonded via an oxygen atom
  • arylalkyloxy means an arylalkyl group bonded via an oxygen atom.
  • Alkoxyalkyl stands for an alkoxy group bonded via an alkyl group
  • alkoxyalkoxy means an alkoxyalkyl group bonded via an oxygen atom, e.g., (but not limited to) methoxymethoxy, methoxyethoxy, ethoxyethoxy, methoxy-n-propyloxy.
  • Alkylthioalkyl stands for an alkyl thio group bonded via an alkyl group
  • alkylthioalkylthio means an alkyl thioalkyl group bonded via an oxygen atom.
  • BCS241005-Abroad STR 61 "Arylalkoxyalkyl” stands for an aryloxy residue bound via an alkyl group, and “Heteroaryloxyalkyl” means a heteroaryloxy residue bound via an alkyl group.
  • “Haloalkoxyalkyl” stands for a bound haloalkoxy residue
  • Haloalkylthioalkyl means a haloalkylthioresidue bound via an alkyl group.
  • Arylalkyl stands for an aryl residue bound via an alkyl group
  • Heteroarylalkyl means a heteroaryl residue bound via an alkyl group
  • Heterocyclylalkyl means a heterocyclyl residue bound via an alkyl group.
  • Cycloalkylalkyl stands for a cycloalkyl residue bound via an alkyl group, e.g. B.
  • Arylalkenyl refers to an aryl group bound via an alkenyl group
  • heteroarylalkenyl refers to a heteroaryl group bound via an alkenyl group
  • heterocyclylalkenyl refers to a heterocyclyl group bound via an alkenyl group.
  • Arylalkynyl refers to an aryl group bound via an alkynyl group
  • heteroarylalkynyl 20 refers to a heteroaryl group bound via an alkynyl group
  • heterocyclylalkynyl refers to a heterocyclyl group bound via an alkynyl group.
  • haloalkylthio on its own or as part of a chemical group - stands for straight-chain or branched S-haloalkyl, preferably with 1 to 8, or with 1 to 625 carbon atoms, such as (C 1 -C 8 )-, (C 1 -C 6 )- or (C 1 -C 4 )-Haloalkylthio, e.g.
  • Halocycloalkyl and “halocycloalkenyl” mean that the haloalkyl group consists of the same or different halogen atoms, such as F, Cl, and Br, or of haloalkyl, such as... B.
  • Trifluoromethyl or difluoromethyl partially or fully substituted cycloalkyl or cycloalkenyl e.g., 1-fluorocycloprop-1-yl, 2-fluorocycloprop-1-yl, 2,2-difluorocycloprop-1-yl, 1-fluorocyclobut-1-yl, 1-trifluoromethylcycloprop-1-yl, 2-trifluoromethylcycloprop-1-yl, 1-chlorocycloprop-1-yl, 2-chlorocycloprop-1-yl, 2,2-dichlorocycloprop-1-yl, 3,3-difluorocyclobutyl, 35
  • "trialkylsilyl" or "tris(alkyl)silyl” - on its own or as part of a chemical group - represents straight-chain or branched Si-alkyl, preferably with 1 to 8, or BCS241005-Foreign STR 62 with 1 to 6 carbon atoms, such
  • Trialkylsilylalkynyl stands for a trialkylsilyl residue bound via an alkynyl group.
  • a compound is obtained with intermediate (III) that is in ortho position to X 1
  • the intermediate (III) contains a metal fragment M' consisting of a metal such as lithium, magnesium, or zinc, as well as suitable ligands (e.g., 2,2,6,6-tetramethylpiperidide).
  • the intermediate (III) is reacted with an aldehyde (IV).
  • the hydroxyl group is substituted by a protected amine, yielding the intermediate of formula 20 (VII).
  • the substituents PG 1 and PG 2 These are amine protecting groups, which can either exist separately or together with the nitrogen atom of the amine, forming a ring.
  • one of the PG residues may be 1 or PG 2
  • the hydrogen group is represented by the diagram in Diagram 2.
  • Diagram 2 Diagram 2: 10 Cross-coupling reactions are useful for incorporating the residues M-1, M-2, and M-3, in which the intermediates (VII) are reacted with such reaction partners of formulas (X-1), (X-2), and (X-3) that, according to the definitions of residues M-1, M-2, and M-3, bear a substituted aryl ring (Scheme 3).
  • substituent X 2 These are substituents typical for cross-coupling reactions, such as a trialkylstannyl group, a boronic acid, or a boronic ester, or a metal fragment consisting of a metal such as zinc, nickel, or magnesium and suitable ligands.
  • Cross-coupling reactions are typically catalyzed by transition metal catalysts such as palladium or copper with suitable ligands such as phosphines or N-heterocyclic carbenes.
  • the cross-coupling reaction can also be carried out such that the roles of X 1 and X 2 are swapped. In this case 20, the cross-coupling reaction would involve substituent X.
  • substituent X would be 2
  • the leaving group may consist of chlorine, bromine, iodine, or a suitable sulfonate.
  • Cross-coupling reactions of pyrazines are described, for example, in WO 2021069575. Cross-coupling reactions of pyrazines with aryl derivatives are also known in the literature, for example, by W. Verboom et al. in Org. Biomol.
  • HOBt 1-hydroxybenzotriazole
  • EDC 1-ethyl-3-(3-5-dimethylaminopropyl)carbodiimide
  • HATU O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate
  • T3P 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide
  • suitable bases e.g. diisopropylethylamine, triethylamine
  • suitable Solvents e.g., dichloromethane, chloroform, acetonitrile
  • esterification can be carried out by transforming group Q-481 in the respective compound of general formula (I) into the acid chloride (XIII-1), (XIII-2), or (XIII-3), for example, using thionyl chloride and subsequent reaction with the corresponding alcohol, using a suitable solvent [e.g., dichloromethane (DCM), chloroform, N,N-dimethylacetamide (DMA), or N,N-dimethylformamide (DMF)].
  • a suitable solvent e.g., dichloromethane (DCM), chloroform, N,N-dimethylacetamide (DMA), or N,N-dimethylformamide (DMF)].
  • Synthesis step 4 (rac)-Methyl-4-(3- ⁇ 1-[(tert-butoxycarbonyl)amino]ethyl ⁇ pyrazin-2-yl)benzoate 5
  • Triethylamine (55.0 g, 544 mmol, 75.7 ml, 2.00 eq.) was added to a solution of methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate (70.0 g, 272 mmol, 1.00 eq.) in THF (350 ml), followed by Boc. 2 O (71.2 g, 326 mmol, 75.0 ml, 1.20 eq.) was added dropwise.
  • reaction mixture was stirred under reflux conditions for 1 h, and after complete conversion (reaction monitored by LC-MS), the mixture was carefully concentrated under reduced pressure and stored without further purification in a mixture of tetrahydrofuran and H2. 2 O (1:1) solved. 20 Then Na 2 CO 3 (3.00 eq) and Boc 2 O2 (5.00 eq) was added and the resulting reaction mixture was stirred for 12 h at room temperature. After complete conversion (reaction control by LC-MS), the reaction mixture was thoroughly extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), and rinsed over Na2. 2 SO 4 Dried, filtered, and concentrated under reduced pressure.
  • reaction progress was monitored by LCMS, and after complete conversion of the starting materials, the reaction mixture was tested for BCS241005-Abroad STR 73 Cooled to room temperature, extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), rinsed over Na 2 SO 4 Dried, filtered, and concentrated under reduced pressure. Purification of the remaining residue (SiO2) by column chromatography. 2 From a gradient of n-heptane/ethyl acetate, methyl 4-(3- ⁇ 1-[(tert-butoxycarbonyl)amino]ethyl ⁇ pyrazin-2-yl)benzoate was obtained as a pale yellow solid.
  • Methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate can also exist in the form of its HCl salt and be used as such in subsequent steps and released by the base used, e.g., triethylamine.
  • Methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate (2000 mg, 7.77 mmol, 1.00 eq) was dissolved under argon in a heated round-bottom flask in absolutes.
  • Methyl 4-(3- ⁇ 1-[3,5-bis(trifluoromethyl)benzamido]ethyl ⁇ pyrazin-2-yl)benzoate (I.1-1) was obtained as a colorless solid (1240 mg, 32% of theory) by column chromatographic purification of the crude product (gradient heptane/ethyl acetate) 20.
  • reaction mixture was then stirred for 15 minutes at room temperature. Subsequently, 25 doses of 2-propanol (30.3 mg, 0.504 mmol, 1.40 eq) and triethylamine (72.9 mg, 0.721 mmol, 2.00 eq) were added successively. The reaction mixture was then stirred for 16 h at room temperature. To complete the reaction, 2-propanol (30.3 mg, 0.504 mmol, 1.40 eq) and triethylamine (72.9 mg, 0.721 mmol, 2.00 eq) were added again, and the mixture was stirred once more for 16 h at room temperature.
  • the resulting reaction mixture was stirred for 30 minutes at -30 °C, cooled again to -78 °C, and treated dropwise with a solution of 2-bromopyrazine (40.0 g, 252 mmol, 1.00 eq) in absolute tetrahydrofuran (120 mL).
  • the resulting reaction mixture was then stirred for 30 minutes at a temperature of -78 °C, followed by the dropwise addition of a solution of cyclopropanecarbaldehyde (35.3 g, 503 mmol, 37.6 mL, 2.20 eq) in abs. tetrahydrofuran (40.0 20 mL), and the reaction mixture was stirred for 60 minutes at a temperature of -78 °C.
  • Synthesis step 2 3-bromopyrazin-2-yl)(cyclopropyl)methanone 30 (3-Bromopyrazin-2-yl)(cyclopropyl)methanol (45.0 g, 196 mmol, 1.00 eq) was dissolved in absolute dichloromethane (315 mL), treated with pyridinium chlorochromate (PCC, 84.7 g, 393 mmol, 2.00 eq) and incubated for 12 h.BCS241005-Ausland STR 79 was stirred at room temperature. After complete conversion (reaction control via thin-layer chromatography), the reaction mixture was filtered and concentrated under reduced pressure. The remaining residue (SiO2) was purified by column chromatography.
  • PCC pyridinium chlorochromate
  • Synthesis step 3 tert-Butyl-[(3-bromopyrazin-2-yl)(cyclopropyl)methyl]carbamate 10
  • ammonium acetate 91.7 g, 1.19 mol, 15.0 eq
  • 3-bromopyrazin-2-yl)(cyclopropyl)methanone (18.0 g, 79.3 mmol, 1.00 eq) in abs. MeOH (126 mL) at room temperature.
  • the resulting reaction mixture was stirred for 2 h at a temperature of 60 °C, then treated with NaBH4.
  • BCS241005-Ausland STR 81 (202 mg, 0.78 mmol, 1.0 eq) and 50% propanephosphonic anhydride were added to THF (0.84 mL, 1.40 mmol, 1.8 eq). The resulting reaction mixture was stirred at room temperature for 14 h, then dichloromethane was added and washed with dilute HCl (1 M). The organic phase was dried over sodium sulfate, filtered, and concentrated under reduced pressure.
  • Methyl 4-(3- ⁇ [3,5-bis(trifluoromethyl)benzamido](cyclopropyl)-methyl ⁇ pyrazin-2-yl)benzoate (I.1-284) was obtained as a colorless solid (350 mg, 83% of theory) by five column chromatographic purifications of the crude product (gradient heptane/ethyl acetate).
  • the resulting reaction mixture was stirred for 30 minutes at -30 °C, cooled again to -78 °C, and treated dropwise with a solution of 2-bromopyrazine (60.0 g, 377 mmol, 1.00 eq) in absolute tetrahydrofuran (180 mL).
  • the resulting reaction mixture was then stirred for 30 minutes at a temperature of -78 °C, followed by the dropwise addition of a solution of propanal (48.2 g, 830 mmol, 60.4 mL, 2.20 eq) in abs. tetrahydrofuran (60.0 mL), and the reaction mixture was stirred for another 60 minutes.
  • reaction mixture was concentrated under reduced pressure, and the resulting 1-(3-bromopyrazin-2-yl)propan-1-amine (18.0 g, 83.3 mmol, 1.00 eq) obtained as a yellow solid was used without further purification in the next reaction step in a mixture of tetrahydrofuran (36.0 mL) and H 2 O (54.0 mL) dissolved. Then Na 2 CO 3 (26.5 g, 250 mmol, 3.00 eq) and Boc 2 O2 (27.3 g, 125 mmol, 28.7 mL, 1.50 eq) was added and the resulting reaction mixture was stirred for 12 h at room temperature (25°C).
  • reaction mixture was thoroughly extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), and rinsed over Na2O. 2 SO 4 Dried, filtered, and concentrated under reduced pressure. Purification of the remaining residue (SiO2) by column chromatography. 2 From a mixture of petroleum ether and ethyl acetate (5:1 to 20:1), tert-butyl-[1-(3-bromopyrazin-2-yl)propyl]carbamate (13.0 g, 49.3% of theory) was obtained as a colorless solid (30 g).
  • TheThe resulting reaction mixture (BCS241005-Ausland STR 85) was stirred for 30 minutes at a temperature of -30 °C, cooled again to -78 °C, and a solution of 2-bromopyrazine (40.0 g, 252 mmol, 1.00 eq) in abs. tetrahydrofuran (120 mL) was added dropwise. The resulting reaction mixture was then stirred for 30 minutes at a temperature of -78 °C, followed by the dropwise addition of a solution of cyclopropanecarbaldehyde (35.3 g, 503 mmol, 37.6 mL, 2.20 eq) in abs.
  • the corresponding stereochemical configuration at the stereocenter C-1 is indicated by the designations “Rac” for a racemic mixture of both enantiomers, “Ent-1” for the enantiomer with the lower retention time in chiral HPLC analysis or chiral preparative SFC, and “Ent-2” for the enantiomer with the higher retention time in chiral HPLC analysis or chiral preparative SFC.
  • the designations 1-methyleth-1-yl, 1-methylethyl, and propyl-2-yl represent an isopropyl group, and the different designations for the same group are common in the field.
  • Table I.1 Preferred compounds of formula (I.1) are compounds I.1-1 to I.1-559, where Q has the meanings given in the respective row of Table I.1. Compounds I.1-1 to I.1-559 of Table I.1 are thus distinguished by the meaning of the respective entries for the substituents R. 1 , R 7 , R 17 , R 18 and R 19 defined in Table I.1, where R 2 , R 5 and R 6 for hydrogen.
  • Table I.1 20 BCS241005-Abroad STR 89 BCS241005-Abroad STR 90 BCS241005-Abroad STR 91 BCS241005-Abroad STR 92 BCS241005-Abroad STR 93 BCS241005-Abroad STR 94 BCS241005-Abroad STR 95 BCS241005-Abroad STR 96 BCS241005-Abroad STR 97 BCS241005-Abroad STR 98 BCS241005-Abroad STR 99 BCS241005-Abroad STR 100 BCS241005-Abroad STR 101 BCS241005-Abroad STR 102 BCS241005-Abroad STR 103 ⁇ Table I.2: Preferred compounds of formula (I.2) are compounds I.2-1 to I.2-225, where Q has the meanings given in the respective row of Table I.2.
  • the peak list of an example therefore has the form: ⁇ 1 (Intensity 1 ) ; ⁇ 2 (Intensity 2 );........; ⁇ i (Intensity i ) ; whil; ⁇ n (Intensity n ) 10
  • the intensity of sharp signals correlates with the height of the signals in a printed example of an NMR spectrum in cm and shows the true ratios of the signal intensities. For broad signals, multiple peaks or the center of the signal and its relative intensity compared to the most intense signal in the spectrum can be shown.
  • To calibrate the chemical shift of 1H-NMR spectra we use tetramethylsilane and/or the chemical shift of the solvent, especially in the case of spectra measured in DMSO.
  • the tetramethylsilane peak may appear in NMR peak lists, but it does not have to.
  • the lists of 1 H-NMR peaks are similar to the classical ones. 1 H-NMR printouts and thus usually contain all the peaks listed in a classical NMR interpretation. Furthermore, they can be interpreted like classical NMR. 1 H-20 NMR printouts show solvent signals, signals of stereoisomers of the target compounds, which are also part of the invention, and/or peaks of impurities.
  • our lists of 1 H-NMR peaks are the usual solvent peaks, for example peaks of DMSO in DMSO-D 6 and the peak of water, shown, which usually exhibits a high average intensity.
  • the peaks of stereoisomers of the target compounds and/or peaks of impurities usually have a lower average intensity than the peaks of the target compounds (for example, with a purity of >90%). Such stereoisomers and/or impurities may be typical for the respective manufacturing process. Their peaks can thus help to recognize the reproducibility of our manufacturing process by means of “by-product fingerprints.”
  • An expert who calculates the peaks of the target compounds using known methods can isolate the peaks of the target compounds as needed, using additional intensity filters if necessary. This isolation would be similar to the peak picking involved in classical 1H-NMR interpretation.
  • the present invention further relates to a method for controlling pests and/or regulating plant growth, characterized in that an effective amount of - one or more compounds of the general formula (I) and/or their salts, as defined above, preferably in one of the embodiments characterized as preferred or particularly preferred, in particular one or more compounds of formulas (I.1-1) to (I.3-18) and/or their salts, each as defined above, or - an agent of the invention, as defined below, is applied to the (pest) plants, (pest) plant seeds, the soil in which or on which the (pest) plants 25 grow, or the cultivation area.
  • an effective amount of - one or more compounds of the general formula (I) and/or their salts as defined above, preferably in one of the embodiments characterized as preferred or particularly preferred, in particular one or more compounds of formulas (I.1-1) to (I.3-18) and/or their salts, each as defined above, or - an agent of the invention, as defined below, is applied to the (pest
  • the present invention also relates to a method for controlling unwanted plants, preferably in crops, characterized in that an effective amount 30 - of one or more compounds of the general formula (I) and/or their salts, as defined above, preferably in one of the embodiments characterized as preferred or particularly preferred, in particular one or more compounds of formulas (I.1-1) to (I.3-18) and/or their salts, each as defined above, or 35 - of an agent according to the invention, as defined below, BCS241005-Abroad STR 245 is applied to unwanted plants (e.g., pest plants such as mono- or dicotyledonous weeds or unwanted cultivated plants), the seed of the unwanted plants (i.e., plant seeds, e.g., grains, seeds, or vegetative propagation organs such as tubers or shoot parts with buds), the soil in which or on which the unwanted plants grow (e.g., the soil of cultivated land or non-cultivated land), or the cultivation area (i.e., the area on which the unwanted plants will grow
  • the present invention further relates to a method for combating and regulating the growth of plants, preferably crop plants, characterized in that an effective amount 10 - of one or more compounds of the general formula (I) and/or their salts, as defined above, preferably in one of the embodiments characterized as preferred or particularly preferred, in particular one or more compounds of formulas (I.1-1) to (I.3-18) and/or their salts, each as defined above, or 15 - of an agent according to the invention, as defined below, is applied to the plant, the seed of the plant (i.e. plant seeds, e.g. grains, seeds or vegetative propagating organs such as tubers or shoot parts with buds), the soil in which or on which the 20 plants grow (e.g.
  • an effective amount 10 - of one or more compounds of the general formula (I) and/or their salts, as defined above preferably in one of the embodiments characterized as preferred or particularly preferred, in particular one or more compounds of formulas (I.1-1) to (I.3-18) and
  • the compounds of general formula (I) or the agents according to the invention can be applied, for example, by pre-sowing (possibly also by incorporation into the soil), pre-emergence, and/or post-emergence application.
  • pre-sowing possibly also by incorporation into the soil
  • pre-emergence and/or post-emergence application.
  • some representatives of the monocotyledonous and dicotyledonous weed flora that can be controlled by the compounds according to the invention are mentioned, without this mention implying a restriction to specific species.
  • one or more compounds of general formula (I) and/or their salts are used to control weeds or to regulate growth in crops of useful or ornamental plants, wherein the useful or ornamental plants are, in a preferred embodiment, transgenic plants.
  • the compounds of general formula (I) and/or their salts according to the invention are suitable for controlling the following genera of monocotyledonous and dicotyledonous weeds: BCS241005-Abroad STR 246 Monocotyledonous harmful plants of the genera: Aegilops, Agropyron, Agrostis, Alopecurus, Apera, Avena, Brachiaria, Bromus, Cenchrus, Commelina, Cynodon, Cyperus, Dactyloctenium, Digitaria, Echinochloa, Eleocharis, Eleusine, Eragrostis, Eriochloa, Festuca, Fimbristylis, Heteranthera, Imperata, Ischaemum, Leptochloa, Lolium, Monochoria, Panicum, Paspalum, Phalaris, Phleum, Poa, Rottboellia, Sagittaria, 5 Scirpus, Setaria, Sorghum.
  • the compounds of general formula (I) according to the invention are applied to the soil surface before the germination of the 15 weeds (grasses and/or weeds) (pre-emergence method), either the emergence of the weed seedlings is completely prevented, or they grow to the cotyledon stage, but then cease growth and finally die completely after three to four weeks. 20
  • the compounds of general formula (I) according to the invention are applied to the green parts of the plants in the post-emergence method, growth stops after treatment, and the weeds remain at the growth stage they were at the time of application or die completely after a certain period, so that in this way weed competition harmful to the cultivated plants is eliminated very early and sustainably.
  • the compounds of the general formula (I) according to the invention exhibit excellent herbicidal activity against mono- and dicotyledonous weeds, cultivated plants of economically important crops, e.g. dicotyledonous crops of the genera Arachis, Beta, Brassica, Cucumis, Cucurbita, Helianthus, Daucus, Glycine, Gossypium, Ipomoea, Lactuca, Linum, Lycopersicon, Miscanthus, Nicotiana, Phaseolus, Pisum, Solanum, Vicia, or monocotyledonous crops 30 of the genera Allium, Ananas, Asparagus, Avena, Hordeum, Oryza, Panicum, Saccharum, Secale, Sorghum, Triticale, Triticum, Zea, are only minimally damaged or not damaged at all, depending on the structure of the respective compound according to the invention and the amount applied.
  • dicotyledonous crops of the genera Arachis, Beta, Brassica, Cucumis,
  • the present compounds are very well suited for the selective control of unwanted plant growth in crops such as agricultural crops or ornamental plantings.
  • the compounds of the general formula (I) according to the invention exhibit (depending on their respective structure and the application rate) excellent BCS241005-Abroad STR 247 exhibits growth-regulating properties in cultivated plants. It intervenes in the plant's own metabolism and can thus be used to selectively influence plant constituents and to facilitate harvesting, for example, by triggering desiccation and growth stunting.
  • it is also suitable for the general control and inhibition of undesirable vegetative growth without killing the plants. Inhibition of vegetative growth plays a major role in many monocot and dicot crops, as it can, for example, reduce or completely prevent lodging.
  • the compounds of general formula (I) according to the invention can also be used to control weeds in crops of genetically modified or conventionally mutagenic plants.
  • the transgenic plants are generally characterized by particularly advantageous properties, for example, resistance to certain pesticides, especially certain herbicides, resistance to plant diseases or pathogens of plant diseases such as certain insects or microorganisms such as fungi, bacteria, or viruses.
  • Other special properties relate, for example, to the harvested crop with regard to quantity, quality, storability, composition, and specific constituents.
  • transgenic plants with increased starch content or altered starch quality, or those with a different fatty acid composition of the harvested crop are known.
  • transgenic crops e.g., cereals such as wheat, barley, rye, oats, millet, rice, and maize, or also crops of sugar beet, cotton, soybean, rapeseed, potato, tomato, pea, and other vegetables.
  • the compounds of general formula (I) according to the invention can also be used as herbicides in crops that are resistant to the phytotoxic effects of the herbicides or have been genetically engineered to be resistant.
  • the compounds of general formula (I) according to the invention can also be used to control weeds in crops of known or yet-to-be-developed genetically modified plants.
  • the transgenic plants are generally characterized by particularly advantageous properties 35, for example, by resistance to certain pesticides, especially certain herbicides, resistance to plant diseases or pathogens of plant diseases such as certain insects or microorganisms such as fungi, bacteria, or viruses.
  • Other special BCS241005-Abroad STR 248 Properties relate, for example, to the harvested crop with regard to quantity, quality, storability, composition, and specific constituents.
  • transgenic plants with increased starch content or altered starch quality, or those with a different fatty acid composition of the harvested crop are known.
  • Further special properties may include tolerance or resistance to abiotic stressors such as heat, cold, drought, salt, and ultraviolet radiation.
  • the application of the compounds of general formula (I) or their salts according to the invention is preferred in economically important transgenic crops of useful and ornamental plants, e.g., cereals such as wheat, barley, rye, oats, triticale, millet, rice, cassava, and maize, or also crops of sugar beet, cotton, soybean, rapeseed, potato, tomato, pea, and other vegetables.
  • the compounds of general formula (I) can be used as herbicides in crops that are resistant to the phytotoxic effects of the herbicides or have been genetically engineered to be resistant.
  • Conventional methods for producing new plants that exhibit modified properties compared to existing plants include, for example, classical breeding methods and the generation of mutants.
  • new plants with altered properties can be produced using genetic engineering techniques.
  • Numerous molecular biological techniques for producing new transgenic plants with altered properties are known to those skilled in the art.
  • nucleic acid molecules can be introduced into plasmids, which allow mutagenesis or sequence modification by recombination of DNA sequences. Using 25 standard methods, for example, base exchanges can be carried out, partial sequences removed, or natural or synthetic sequences added.
  • Adaptors or linkers can be attached to the DNA fragments to join them together.
  • the production of plant cells with reduced activity of a gene product can be achieved, for example, by expressing at least one corresponding antisense RNA, a sense RNA to achieve a cosuppression effect, or the expression of at least one appropriately engineered ribozyme that specifically cleaves transcripts of the aforementioned gene product.
  • DNA molecules can be used that comprise the entire coding sequence of a gene product, including any flanking sequences, as well as DNA molecules that comprise only parts of the coding sequence, provided these parts are long enough, BCS241005-Abroad STR 249 to induce an antisense effect in the cells.
  • DNA sequences that exhibit a high degree of homology to the coding sequences of a gene product can be used, but are not completely identical. 5
  • the synthesized protein can be localized in any compartment of the plant cell.
  • the coding region can, for example, be linked to DNA sequences that ensure localization in a particular compartment.
  • Such sequences are known to those skilled in the art (see, for example, Braun et al., EMBO J. 11 (1992), 3219-3227).
  • the expression of the nucleic acid molecules can also take place in the organelles of the plant cells.
  • the transgenic plant cells can be regenerated into whole plants using known techniques.
  • transgenic plants can be from any of the 15 plant species, i.e., both monocotyledonous and dicotyledonous plants.
  • the compounds of general formula (I) according to the invention can be used in transgenic cultures which are resistant to growth regulators, such as dicamba, or to herbicides that inhibit essential plant enzymes, e.g.
  • acetolactate synthases ALS
  • EPSP synthases glutamine synthases
  • HPPD hydroxyphenylpyruvate dioxygenases
  • the compounds of general formula (I) according to the invention are applied in transgenic crops, in addition to the effects observed in other crops against weeds, 30 effects often occur that are specific to the application in the respective transgenic crop, for example, an altered or specifically expanded weed spectrum that can be controlled, altered application rates that can be used, preferably good compatibility with the herbicides to which the transgenic crop is resistant, as well as influencing the growth and yield of the transgenic crop plants. 35 ... BCS241005-Abroad STR 250
  • the invention therefore also relates to the use of the compounds of general formula (I) and/or their salts as herbicides for controlling weeds in crops of useful or ornamental plants, optionally in transgenic crops.
  • the invention also relates to the use of one or more compounds of the general formula (I) or their salts or of an agent according to the invention (as defined below) (in a method) for controlling pests or for regulating plant growth, characterized in that an effective amount of one or more compounds of the general formula (I) or their salts is applied to the plants (pests, optionally together with the 20 crop plants), plant seeds, the soil in which or on which the plants grow, or the cultivation area.
  • the invention also relates to a herbicidal and/or plant growth regulator, characterized in that the agent 25 (a) contains one or more compounds of general formula (I) and/or their salts as defined above, preferably in one of the embodiments characterized as preferred or particularly preferred, in particular one or more compounds of formulas (I.1-1) to (I.3-18) and/or their salts, each as defined above, 30 and (b) one or more further substances selected from groups (i) and/or (ii): (i) one or more further agrochemically active substances, preferably selected from the group 35 consisting of insecticides, acaricides, nematicides, further herbicides (i.e., those not corresponding to general formula (I) defined above), fungicides, safeners, fertilizers and/or further growth regulators, BCS241005-Abroad STR 251 (ii) one or more formulation aids commonly used in plant protection.
  • the agent 25 contains one or more compounds of general formula (I) and/or
  • the further agrochemical active substances of component (i) of a composition 5 according to the invention are preferably selected from the group of substances listed in "The Pesticide Manual", 16th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2012.
  • a herbicidal or plant growth regulator according to the invention preferably comprises one, two, three or more formulation aids (ii) commonly used in plant protection, selected from the group consisting of surfactants, emulsifiers, dispersants, film formers, thickeners, inorganic salts, dusting agents, carriers solid at 25 °C and 1013 mbar, preferably adsorbable, granulated inert materials, wetting agents, antioxidants, stabilizers, buffer substances, antifoaming agents, water, organic solvents, preferably organic solvents miscible with water in any desired ratio at 25 °C and 1013 mbar.
  • the compounds according to the invention of general formula (I) can be used in the form of sprayable powders, emulsifiable concentrates, sprayable solutions, dusting agents or granules in conventional preparations.
  • the invention therefore also relates to herbicidal and plant growth regulators containing compounds of general formula (I) and/or their 20 salts.
  • the compounds of general formula (I) and/or their salts according to the invention can be formulated in various ways, depending on which biological and/or physicochemical parameters are specified.
  • Possible formulations include, for example: 25 spray powders (WP), water-soluble powders (SP), water-soluble concentrates, emulsifiable concentrates (EC), emulsions (EW) such as oil-in-water and water-in-oil emulsions, sprayable solutions, suspension concentrates (SC), oil- or water-based dispersions, oil-miscible solutions, capsule suspensions (CS), dusting agents (DP), pickling agents, granules for broadcast and ground application, granules (GR) in the form of micro-, spray-, lift- and adsorption granules, 30 water-dispersible granules (WG), water-soluble granules (SG), ULV formulations, microcapsules and waxes.
  • WP spray powders
  • SP water-soluble powders
  • EC emulsifiable concentrates
  • EW emulsions
  • SC suspension concentrates
  • CS oil- or water-based dispersions
  • Spray powders are preparations that are uniformly dispersible in water and, in addition to the active ingredient, contain surfactants of ionic and/or non-ionic nature (wetting agents, dispersing agents), e.g., polyoxyethylated alkylphenols, polyoxyethylated fatty alcohols, polyoxyethylated fatty amines, fatty alcohol polyglycol ether sulfates, alkanesulfonates, alkylbenzenesulfonates, sodium ligninsulfonic acid, 2,2'-dinaphthylmethane-6,6'-disulfonic acid sodium,
  • the herbicidal active ingredients are found in dibutylnaphthalenesulfonic acid sodium 10 or oleoylmethyltauric acid sodium.
  • the herbicidal active ingredients are finely ground in conventional equipment such as hammer mills, blower mills, and air jet mills and simultaneously or subsequently mixed with the formulation aids.
  • Emulsifiable concentrates are produced by dissolving the active ingredient in an organic solvent, e.g., butanol, cyclohexanone, dimethylformamide, xylene, or higher-boiling aromatics or hydrocarbons, or mixtures of organic solvents, with the addition of one or more ionic and/or non-ionic surfactants (emulsifiers).
  • emulsifiers include: calcium alkylarylsulfonic acid salts such as calcium dodecylbenzenesulfonate 20, or non-ionic emulsifiers such as fatty acid polyglycol esters, alkylaryl polyglycol ethers, fatty alcohol polyglycol ethers, and propylene oxide-ethylene oxide condensation products.
  • Dusts are obtained by grinding the active ingredient with finely divided solids, e.g., talc, natural clays such as kaolin, bentonite, and pyrophyllite, or diatomaceous earth.
  • Suspension concentrates can be water- or oil-based. They can be produced, for example, by wet milling using commercially available bead mills and, if necessary, the addition of surfactants, such as those already listed above under the other formulation types.
  • Emulsions e.g., oil-in-water emulsions (EW)
  • EW oil-in-water emulsions
  • 35 Granules can be produced either by The active ingredient can be atomized onto adsorbable, granulated inert material or applied by means of adhesives. These products are manufactured by atomizing the active ingredient onto adsorbable, granulated inert material or by applying active ingredient concentrates using adhesives.
  • BCS241005-Abroad STR 253 e.g., polyvinyl alcohol, sodium polyacrylate, or mineral oils, are applied to the surface of carrier materials such as sand, kaolinite, or granulated inert material.
  • carrier materials such as sand, kaolinite, or granulated inert material.
  • active ingredients can also be granulated in the manner customary for the production of fertilizer granules—optionally in mixture with fertilizers.
  • Water-dispersible granules are generally produced using standard methods such as spray drying, fluidized bed granulation, disc granulation, mixing with high-speed mixers, and extrusion without solid inert material.
  • the agrochemical preparations preferably herbicidal or plant growth regulators of the present invention, preferably contain a total amount of 0.1 to 99 wt.%, more preferably 0.5 to 95 wt.%, further preferably 1 to 90 wt.%, and particularly preferably 2 to 80 wt.%, of active ingredients of general formula (I) and their salts.
  • the active ingredient concentration is, for example, about 10 to 90 wt.%, the remainder to 100 wt.% consisting of usual formulation components.
  • the active ingredient concentration can be about 1 to 90 wt.%, preferably 5 to 80 wt.%.
  • Powder formulations contain 1 to 30 wt.% active ingredient, preferably mostly 5 to 20 wt.% active ingredient; sprayable solutions contain about 0.05 to 80 wt.%, preferably 2 to 50 wt.% active ingredient.
  • the active ingredient content depends partly on whether the active compound is liquid or solid and which granulation aids, fillers, etc., are used.
  • the active ingredient content is, for example, between 1 and 95 wt.%, preferably between 10 and 80 wt.%.
  • the aforementioned active ingredient formulations may contain the usual adhesives, wetting agents, dispersants, emulsifiers, penetrating agents, preservatives, antifreeze agents and solvents, fillers, carriers and colorants, defoamers, evaporation inhibitors and the pH value and viscosity.
  • BCS241005-Abroad STR 254 influencing agents are described, among others, in “Chemistry and Technology of Agrochemical Formulations", ed. D. A. Knowles, Kluwer Academic Publishers (1998).
  • the compounds of general formula (I) according to the invention or their salts can be used as such or in the form of their preparations (formulations) in combination with other pesticides, such as insecticides, acaricides, nematicides, herbicides, fungicides, safeners, fertilizers and/or growth regulators, e.g. as finished formulations or as tank mixes.
  • pesticides such as insecticides, acaricides, nematicides, herbicides, fungicides, safeners, fertilizers and/or growth regulators, e.g. as finished formulations or as tank mixes.
  • the combination formulations can be prepared on the basis of the above-mentioned 10 formulations, taking into account the physical properties and stabilities of the active ingredients to be combined.
  • known active ingredients based on the inhibition of, for example, acetolactate synthase, acetyl-CoA carboxylase, cellulose synthase, enolpyruvylshikimate-3-phosphate synthase, glutamine synthetase, p-hydroxyphenylpyruvate dioxygenase, phytoendesaturase, photosystem I, photosystem II, and protoporphyrinogen oxidase can be used as combination partners for the compounds of general formula (I) according to the invention in mixture formulations or in tank mixes.
  • active ingredients include, for example, known active ingredients based on the inhibition of, for example, acetolactate synthase, acetyl-CoA carboxylase, cellulose synthase, enolpyruvylshikimate-3-phosphate synthase, glutamine synthase, p-hydroxyphenylpyruvate dioxygenase, phytoendesaturase, photosystem I, photosystem II, and protoporphyrinogen oxidase, as described, for example, in Weed Research 26 (1986) 441-445 or "The Pesticide Manual", 16th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2012, and the literature cited therein.
  • the safeners which are used in an antidotally effective concentration, reduce the phytotoxic side effects of the herbicides/pesticides used, e.g., in economically important crops such as cereals (wheat, barley, rye, maize, rice, millet), sugar beet, sugar cane, rapeseed, cotton, and soybeans, preferably cereals.
  • the weight ratio of herbicide (mixture) to safener generally depends on the application rate of herbicide and the efficacy of the respective safener and can vary within wide limits, for example in the range of 200:1 to 1:200, preferably 100:1 to 1:100, particularly 20:1 to 1:20.
  • the safeners can be formulated analogously to the compounds of general formula (I) BCS241005-Abroad STR 255 or mixtures thereof with other herbicides/pesticides are formulated and provided and applied as a ready-to-use formulation or tank mix with the herbicides.
  • the commercially available herbicide or herbicide-safener formulations are optionally diluted in the usual manner, e.g., in the case of spray powders, emulsifiable concentrates, dispersions, and water-dispersible granules, by means of water. Powdery preparations, soil or granular coatings, and sprayable solutions are not usually diluted with further inert substances before application.
  • the application rate of the compounds of general formula (I) and/or their salts according to the invention can vary within wide limits.
  • the total amount of the compounds of general formula (I) and their salts according to the invention is preferably in the range of 0.001 to 10.0–15 kg/ha, more preferably in the range of 0.005 to 5 kg/ha, further preferably in the range of 0.01 to 1.5 kg/ha, and particularly preferably in the range of 0.05 to 1 kg/ha. This applies to both pre-emergence and post-emergence application.
  • the total application rate is preferably in the range of 0.001 to 2 kg/ha, more preferably in the range of 0.005 to 1 kg/ha, particularly in the range of 10 to 500 g/ha, and most preferably in the range of 20 to 250 g/ha.
  • Application as a stem shortener can take place at various stages of plant growth. For example, application after tillering at the beginning of stem elongation is preferred.
  • seed treatment is also an option, which includes various seed dressing and coating techniques.
  • the application rate depends on the specific technique and can be determined in preliminary trials.
  • known active ingredients based on the inhibition of, for example, are suitable combination partners for the compounds of general formula (I) in mixture formulations or in tank mixes.
  • BCS241005-Abroad STR 256 Acetolactate synthase, acetyl-CoA carboxylase, cellulose synthase, enolpyruvylshikimate-3-phosphate synthase, glutamine synthetase, p-hydroxyphenylpyruvate dioxygenase, phytoendesaturase, photosystem I, photosystem II, protoporphyrinogen oxidase are based on or act as plant growth regulators, as described, for example, in Weed Research 26 (1986) 441-445 or 5 "The Pesticide Manual", 19th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2021 and the literature cited therein.
  • Examples of well-known herbicides or plant growth regulators that can be combined with compounds of the general formula (I) include the following active substances (the compounds are designated either by the "common name” according to the International Organization for Standardization (ISO) or by the chemical name or by the code number) and always include all application forms such as acids, salts, esters and isomers such as stereoisomers and optical isomers.
  • Examples of applications include: Acetochlor, Acifluorfen, Acifluorfen-methyl, Acifluorfen-sodium, Aclonifen, Alachlor, Allidochlor, 15-Alloxydim, Alloxydim-sodium, Ametryn, Amicarbazone, Amidochlor, Amidosulfuron, 4-Amino-3-chloro-6-(4-chloro-2-fluoro-3-methylphenyl)-5-fluoropyridine-2-carboxylic acid, Aminocyclopyrachlor, Aminocyclopyrachlor-potassium, Aminocyclopyrachlor-methyl, Aminopyralid, Aminopyralid-dimethylammonium, Aminopyralid-tripromine, Amitrole, Ammonium sulfamates, Anilofos, Asulam, Asulam-potassium, Asulam-sodium, Atrazine, Azafenidine, Azimsulfuron
  • dicamba biproamine dicamba-N,N-bis(3-aminopropyl)methylamine, Dicamba butotyl, Dicamba choline, Dicamba-10 diglycolamine, Dicamba dimethylammonium, Dicamba diethanolaminemmonium, Dicamba diethylammonium, Dicamba isopropylammonium, Dicamba methyl, Dicamba monoethanolamine, Dicamba olamine, Dicamba potassium, Dicamba sodium, Dicamba triethanolamine), Dichlobenil, 2-(2.4- Dichlorobenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one, 2-(2,5-dichlorobenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one, dichlorprop, dichlorprop-butotyl, dichlorprop-dimethylammonium, dichlorprop-etexyl, 15 dichlorprop-ethylammonium, dichlorprop-isoc
  • O-(2,4-dimethyl-6-nitrophenyl)-O-ethyl-5 isopropylphosphoramidothioate, Halauxifen, Halauxifen-methyl, Halosafen, Halosulfuron, Halosulfuron-Methyl, Haloxyfop, Haloxyfop-P, Haloxyfop-Ethoxyethyl, Haloxyfop-P-Ethoxyethyl, Haloxyfop-Methyl, Haloxyfop-P-Methyl, Haloxifop Sodium, Hexazinone, HNPC-A8169, i.e.
  • COs in some cases referred to as N-acetylchitooligosaccharides 30, are also composed of GlcNAc units, but have side chains that distinguish them from chitin molecules [(C 8 H 13 NO 5 ) n , CAS No.1398-61-4] and chitosan molecules [(C 5 H 11 NO 4 ) n , CAS No.
  • chitin-like compounds chlormequat chloride, cloprop, cyclanilides, 3-(cycloprop-1-enyl)propionic acid, 1-[2-(4-cyano-3,5-dicyclopropylphenyl)acetamido]cyclohexanecarboxylic acid, 1-[2-(4-cyano-3,5-cyclopropylphenyl)acetamido]cyclohexanecarboxylic acid, 1-cyclopropenylmethanol, daminozide, dazomet, dazomet sodium, n-decanol, dikegulac, dikegulac sodium, endothal, endothal dipotassium, disodium, and mono(N,N-dimethylalkylammonium), ethephon, 1-ethylcyclopropene, flumetraline, BCS241005-Abroad STR 262 Flurenol, fluorenol-butyl,
  • LCOs in the number of GlcNAc units in the backbone structure, in the length and saturation of the fatty acid chain, and in the substitution of the reducing and non-reducing sugar units), linoleic acid or its derivatives, linolenic acid or its derivatives, maleic hydrazide, mepiquat chloride, mepiquat pentaborate, 1-methylcyclopropene, 3-methylcyclopropene, methoxyvinylglycine (MVG), 3’-methylabscisic acid, 1-(4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide and related substituted (tetrahydroquinolin-6-yl)methanesulfonamides, (3E,3aR,8bS)-3-( ⁇ [(2R)-4-methyl-5-oxo-2,5- 15
  • n A is a natural number from 0 to 5, preferably 0 to 3; BCS241005-Abroad STR 263 R A 1 is halogen, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Alkoxy, Nitro or (C 1 -C 4 )-Haloalkyl; ⁇ 7) W A is an unsubstituted or substituted divalent heterocyclic residue from the group of division-saturated or aromatic five-membered heterocycles with 1 to 3 heteroring atoms from group 5 N and O, wherein at least one N atom and at most one O atom is contained in the ring, preferably a residue from the group (W A 1 ) to (W A 5 ), m A is 0 or 1; R A
  • R C 1 is (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Haloalkyl, (C 2 -C 4 )-Alkenyl, (C 2 -C 4 )-Haloalkenyl, (C 3 -C 7 )-Cycloalkyl, preferably dichloromethyl;
  • R C 2 , R C 3 are the same or different hydrogen, (C 1 -C 4 )-Alkyl, (C 2 -C 4 )-Alkenyl, (C 2 -C 4 )Alkynyl, (C 1 - C 4 )Haloalkyl, (C 2 -C 4 )Haloalkenyl, (C 1 -C 4 )Alkylcarbamoyl-(C 1 -C 4 )alkyl, (C 2 -C 4 )
  • X D is CH or N;
  • R D 1 is CO-NR D 5 R D 6 or NHCO-R D 7 ;
  • R D 2 is halogen, (C 1 -C 4 )-Haloalkyl, (C 1 -C 4 )-Haloalkoxy, Nitro, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Alkoxy, (C 1 -10°C 4 )-Alkylsulfonyl, (C 1 -C 4 )-Alkoxycarbonyl or (C 1 -C 4 )-Alkylcarbonyl;
  • R D 3 is hydrogen, (C 1 -C 4 )-Alkyl, (C 2 -C 4 )-Alkenyl or (C 2 -C 4 )-Alkyn
  • S5 Active ingredients from the class of hydroxyaromatics and aromatic-aliphatic 20 carboxylic acid derivatives (S5), e.g. 3,4,5-triacetoxybenzoic acid ethyl ester, 3,5-di-methoxy-4-hydroxybenzoic acid, 3,5-dihydroxybenzoic acid, 4-hydroxysalicylic acid, 4-fluorosalicyclic acid, 2-hydroxycinnamic acid, 2,4-dichlorocinnamic acid, as described in WO-A-2004/084631, WO-A-2005/015994, WO-A-2005/016001.
  • S6 active ingredients from the class of 1,2-dihydroquinoxalin-2-ones (S6), e.g.
  • R E 1 , R E 2 are independent of each other halogen, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Alkoxy, (C 1 -C 4 )-Haloalkyl, (C 1 - C 4 )-Alkylamino, Di-(C 1 -C 4 )-Alkylamino, Nitro;
  • a E is COOR E 3 or COSR E 4 R E 3 , R E 4 are independent of each other hydrogen, (C 1 -C 4 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 4 )-Alkynyl, 10 Cyanoalkyl, (C 1 -C 4 )-Haloalkyl, phenyl, nitrophenyl, benzyl,
  • Phenyl possibly substituted phenoxy, R F 2 hydrogen or (C 1 -C 4 )-Alkyl, 5 R F 3 Hydrogen, (C 1 -C 8 )-Alkyl, (C 2 -C 4 )-Alkenyl, (C 2 -C 4 )-Alkynyl, or aryl, wherein each of the aforementioned C-containing residues is unsubstituted or substituted by one or more, preferably up to three identical or different residues from the group consisting of halogen and alkoxy; mean, or their salts, preferably compounds wherein 10 X F CH, n F an integer from 0 to 2, R F 1 Halogen, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Haloalkyl, (C 1 -C 4 )-Alkoxy, (C 1 -C 4 )-Haloalkoxy, R F 2 hydrogen or (C 1 -C 4
  • Active ingredients from the class of 3-(5-tetrazolylcarbonyl)-2-quinolones e.g. 1,2-Dihydro-4-hydroxy-1-ethyl-3-(5-tetrazolylcarbonyl)-2-quinolone (CAS Reg. No. 219479-18-2), 1,2-20-Dihydro-4-hydroxy-1-methyl-3-(5-tetrazolylcarbonyl)-2-quinolone (CAS Reg. No. 95855-00-8), as described in WO-A-1999/000020.
  • S11 Active substances of the oxyimino compound type (S11) known as seed dressings, such as e.g. B. "Oxabetrinil” ((Z)-1,3-dioxolan-2-ylmethoxyimino(phenyl)acetonitrile) (S11-1), known as a seed treatment safener for millet against damage caused by metolachlor, "Fluxofenim” (1-(4-10 Chlorophenyl)-2,2,2-trifluoro-1-ethanone-O-(1,3-dioxolan-2-ylmethyl)-oxime) (S11-2), known as a seed treatment safener for millet against damage caused by metolachlor, and "Cyometrinil” or “CGA-43089” ((Z)-cyanomethoxyimino(phenyl)acetonitrile) (S11-3), known as a seed treatment safener for millet against damage caused by metolachlor.
  • S12 Active substances from the class of isothiochromanones (S12), such as methyl-[(3-oxo-1H-2- 15 benzothiopyran-4(3H)-ylidene)methoxy]acetate (CAS Reg. No. 205121-04-6) (S12-1) and related compounds from WO-A-1998/13361.
  • S12 isothiochromanones
  • S13 One or more compounds from group (S13): "Naphthalic anhydride” (1,8-naphthalenedicarboxylic anhydride) (S13-1), known as a seed treatment safener for maize against damage from thiocarbama herbicides, "Fenclorim” (4,6-dichloro-2-phenylpyrimidine) (S13-2), known as a safener for pretilachlor in sown rice, "Flurazole” (benzyl-2-chloro-4-trifluoromethyl-1,3-thiazol-5-carboxylate) (S13-3), known as a seed treatment safener for millet against damage from alachlor and metolachlor, "CL 304415” (CAS Reg.
  • the following compounds according to the invention also exhibited very good herbicidal activity (> 80%) at an application rate of 15,950 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-40, I.1-47, I.1-49, I.1-50, I.1-52, I.1-53, I.1-68, I.1-70, I.1-79, I.1-80, I.1-93, I.1-145, I.1-149, I.2-1, I.1-152, I.1-153, I.2-5, I.2-7, I.1-155, I.1-157, I.1-158, I.2-8, I.2-6, I.2-11, I.2-10, I.2-13, I.1-169, I.2-15, I.2-17
  • the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-40, I.1-47, I.1-49, I.1-50, I.1-52, I.1-53, I.1-68, I.1-70, I.1-79, I.1-80, I.1-93, I.1-143, I.1-145, I.1-149, I.2-1, I.1-152, I.1-153, I.2-5, I.1-155, I.1-157, I.1-158, I.2-8, I.2-6, I.2-11, I.2-10, I.2-13, I.1-252, I.1-169, I.2-15,
  • the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-40, I.1-47, I.1-49, I.1-50, I.1-52, I.1-53, I.1-68, I.1-70, I.1-80, I.1-93, I.1-145, I.1-149, I.1-1, I.1-152, I.1-153 I.1-155, I.1-157, I.1-158, I.2-8, I.2-11, I.2-10, I.2-13, I.1-252, I.1-169, I.1-178, I.2-36, I.2-25, I.2-32, I.2-27, I.2-29
  • the following compounds according to the invention also exhibited very good herbicidal activity (> 80%) at an application rate of 35,950 g of active substance per hectare: I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-223, I.1-32, I.1-35, I.1-40, I.1-49, I.1-52, I.1-53, I.1-68, I.1-80, I.1-93, I.1-145, I.1-149, I.1-152, I.1-153, I.1-155, I.2-10, I.2-13, I.1-255, I.1-169, I.1-174, I.1-178, I.2-32, I.2-27, I.2-29, I.1-203, I.1-201, BCS241005-Foreign STR 278 I.1-206, I.1-260, I.1-272, I.
  • the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-32, I.1-40, I.1-68, I.1-80, I.1-145, I.1-149, I.1-152, I.1-153, I.1-155, I.1-157, I.2-11, I.2-10, I.2-13, I.1-174, I.2-32, I.2-27, I.1-260, I.1-272, I.1-274 I.1-279, I.1-280, I.2-82, I.2-84, I.1-316, I.1-315, I.2-95, I.1-334, I.1-337, I.1-347, I.1-346, I.1-357, I.1-359, I.1-341, I.1-345, I.1-3
  • the following compounds according to the invention also exhibited very good herbicidal activity (> 80%) at an application rate of 35,950 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-40, I.1-47, I.1-49, I.1-50, I.1-68, I.1-70, I.1-80, I.1-93, I.1-143, I.1-145, I.1-150, I.1-1, I.1-152, I.1-153, I.1-155, I.1-156, I.1-157, I.1-158, I.2-10, I.2-13, I.1-169, I.1-174, I.1-177, BCS241005-Abroad STR 279 I.2-32, I.2-27, I.2-29, I
  • the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-36, I.1-40, I.1-47, I.1-49, I.1-50, I.1-68, I.1-70, 10 I.1-79, I.1-80, I.1-93, I.1-143, I.1-145, I.1-152, I.1-153, I.1-155, I.1-156, I.1-157, I.1-158, I.2-10, I.2-13, I.1-169, I.1-174, I.2-32, I.2-27, I.2-29, I.1-202, I.1-203, I.1-201, I.1-212, I.1-213, I.
  • the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-36, I.1-40, I.1-47, I.1-49, I.1-50, I.1-68, I.1-70, I.1-80, I.1-143, I.1-145, I.1-2-1, I.1-152, I.1-20, I.1-153, I.1-155, I.1-156, I.1-157 I.1-158, I.2-10, I.2-13, I.1-174, I.2-32, I.2-27, I.2-29, I.1-203, I.1-201, I.1-212, I.1-213, I.1-259, I.1-274, I.1-280, I.
  • the compounds according to the invention also exhibited very good herbicidal activity (> 80%) at an application rate of 950 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-18, I.1-19, I.1-32, I.1-35, I.1-40, I.1-50, I.1-52, I.1-66, I.1-68, I.1-70, I.1-80, I.1-93, I.1-145, I.1-149, I.1-150, I.2-1, I.1-152, I.1-153, I.1-157, I.2-10, I.2-13, I.1-174, I.1-177 I.1-178, I.2-32, I.2-27, I.2-29, I.1-202, I.1-201, I.1-207, I.1-5 260, I.1-271, I.1-272, I.2-75, I.2-84, I.1-308
  • the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-18, I.1-26, I.1-32, I.1-35, I.1-40, I.1-49, I.1-50, I.1-52, I.1-68, I.1-70, I.1-80, I.1-93, I.1-145, I.1-152, I.1-153, I.1-155, I.2-10, I.1-174, I.1-177, I.1-178, I.2-27, I.2-29, I.1-201, I.1-207, I.1-280, I.2-82, I.2-84, I.1-316, I.1-15 356, I.1-338, I.1-348, I.1-337, I.1-347, I.1-346, I.1-345, I.2-103, I.1-371, I.1-412, I.2-122, I
  • the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-20, I.1-18, I.1-35, I.1-40, I.1-50, I.1-68, I.1-70, I.1-80, I.1-93, I.1-145, I.2-1, I.1-152, I.1-153, I.2-10, I.1-174, I.1-178, I.2-29, I.2-41, I.2-82, I.2-84, I.1-316, I.1-338, I.1-348, I.1-337, I.1-347, I.1-346, I.1-345, I.1-371, I.2-123, I.2-125, I.1-418, I.1-431, I.1-433, I.1-434, I.1-435, I.1-437, I.2-167, I.1-439, I.1-441, I.2-182
  • the following compounds according to the invention also had very good BCS241005-Ausland STR 281 herbicidal effect (> 80%) at an application rate of 950 g of active substance per hectare: I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-40, I.1-47, I.1-49, I.1-50, I.1-153, I.2-7, I.1-155, I.2-10, I.2-27, I.1-203, I.1-210, I.1-212, I.1-213, I.3-13, I.1-291, I.1-294, I.2-66, I.2-82, I.2-84, I.1-316, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-336, I.1-325, I.1-323, I.1-361, I.1-362, I.1-340, I.1-341, I.1-5 3
  • the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-14, I.1-16, I.1-18, I.1-20, I.1-1021, I.1-22, I.1-40, I.1-50, I.1-145, I.1-155, I.2-27, I.1-203, I.1-212, I.1-294, I.2-82, I.2-84, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-323, I.1-329, I.1-362, I.1-340, I.1-345, I.2-103, I.2-104, I.1-404, I.2-122, I.2-123, I.2-125, I.1-418, I.1-419, I.2-156, I.1-431, I.1-433, I.1-434, I.1-437, I.1-438, I.1-443, I.2-181, I.2-182, I
  • the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-14, I.1-16, I.1-20, I.1-21, I.1-22, I.1-50, I.1-155, I.1-203, I.2-82, I.1-348, I.1-347, I.1-346, I.2-103, I.2-122, I.2-123, I.2-125, I.1-418, I.1-433, I.1-434, I.1-437, I.1-443, I.2-182, I.1-556.
  • I.1-14 I.1-16, I.1-20, I.1-21, I.1-22, I.1-50, I.1-155, I.1-203, I.2-82, I.1-348, I.1-347, I.1-346, I.2-103, I.2-122, I.2-123, I.2-125, I.1-418, I.1-433, I.1-434, I.1-437, I.1-4
  • the following compounds according to the invention also exhibited very good herbicidal activity (> 80%) at an application rate of 950 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-38, I.1-40, I.1-50, I.1-53, I.1-68, I.1-80, I.1-142, I.1-145, I.1-150, I.2-1, I.1-152, I.1-153, I.1-156, I.1-157, I.1-158, I.2-6, I.2-13, I.1-177, 5 I.2-25, I.2-27, I.2-29, I.1-196, I.1-202, I.1-203, I.1-200, I.1-201, I.1-212, I.1-213, I.3-14, I.3-13, I.1-259, I.2-37, I
  • the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-35, I.1-38, I.1-40, I.1-47, I.1-50, I.1-53, I.1-68, I.1-145, I.1-150, I.1-155, I.2-13, I.2-25, I.2-27, I.2-29, I.1-196, I.1-200, I.1-201, I.1-206, I.1-210, I.1-212, I.1-213, I.1-259, I.2-37, I.1-270, I.1-272, I.1-274, I.2-75, I.2-82, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-20 3
  • the following 25 compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-38, I.1-50, I.1-152, I.1-155, I.2-29, I.1-203, I.1-201, I.1-212, I.1-213, I.2-82, I.1-334, I.1-338, I.1-348, I.1-347, I.1-346, I.1-323, I.1-361, I.1-363, I.1-345, I.2-109, I.1-397, I.1-400, I.1-401, I.2-125, I.1-420, I.2-156, I.1-432, I.1-433, I.1-434, I.1-435, I.1-436, I.1-437, I.1-438, I.2-167, I.2-170, I.1-445, I.1-448, I.
  • the following compounds according to the invention also exhibited very good herbicidal activity (> 80%) at an application rate of 950 g of active substance per hectare: I.1-16, I.1-18, I.1-22, I.1-29, I.1-40, I.1-49, I.1-50, I.1-80, I.1-93, I.2-7, I.1-177, I.2-32, I.2-27, I.1-184, I.3-14, I.1-260, I.1-316, I.1-348, I.1-337, I.1-347, I.1-346, I.1-339, I.1-341, I.2-104, I.1-398, I.1-401, I.2-156, I.2-177, I.2-182, I.2-191, I.1-454, I.1-557, I.2-209, I.1-515.
  • the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-21, I.1-93, I.1-177, I.2-32, I.2-27, I.1-316, I.1-348, I.1-347, I.1-346, I.1-401, I.2-156, I.1-437, I.2-182, I.2-191, I.1-513. Furthermore, the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-16, I.1-21, I.1-50, I.1-348, I.1-347, I.2-156, I.2-182, I.1-495.
  • the following compounds according to the invention also exhibited very good herbicidal activity (> 80%) at an application rate of 950 g of active substance per hectare: I.1-6, I.1-9, I.1-12, I.1-14, I.1-16, I.1-17, I.1-21, I.1-47, I.1-68, I.1-80, I.1-93, I.1-145, I.1-153, I.1-155, I.1-157, I.1-158, I.2-10, I.2-13, I.1-255, I.1-169, I.1-177, I.2-20, I.2-25, I.2-27, I.2-29, I.1-203, I.1-212, I.1-213, I.1-259, I.2-47, I.1-272, I.2-79, I.2-84,30 I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-324, I.1-359, I.1-323,
  • the following compounds according to the invention showed a very good herbicidal effect (> 80%) at an application rate of 475 g of active substance per hectare: I.1-6, I.1-12, I.1-21, I.1-93, I.1-145, I.1-153, I.1-155, I.1-157, I.1-158, I.2-13, I.1-177, I.2-25, I.2-27, I.2-29, I.1-203, I.1-212, I.1-213, I.2-82, I.2-84, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-361, BCS241005-Foreign STR 284 I.1-341, I.1-345, I.1-371, I.2-108, I.1-400, I.1-422, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-169, I.1-439, I.2-176
  • the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-12, I.1-521, I.1-93, I.1-155, I.1-157, I.1-177, I.1-203, I.1-212, I.1-348, I.1-337, I.1-347, I.1-346, I.1-341, I.1-345, I.1-400, I.2-123, I.1-422, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-169, I.2-181, I.2-182, I.1-448, I.1-451, I.2-191, I.1-458, I.1-558, I.1-557, I.1-556, I.1-495, I.1-513.
  • compounds according to the invention exhibit good herbicidal efficacy against weeds when treated 10 in early post-emergence.
  • compounds I.1-12, I.1-16, I.1-21, I.2-1, I.2-27, and I.2-29 exhibit very good herbicidal activity (80% to 100% herbicidal activity) against weeds such as Agrostis tenuis, Diplotaxis muralis, Diplotaxis tenuis, Lolium perenne, Matricaria chamomilla, Poa annua, Setaria viridis, Stellaria media, and Veronica persica in the post-emergence application method described above, at application rates of 15, 1900, 950, 475, and 238 g of active substance per hectare, respectively.
  • Pre-emergence herbicide activity – Part I Seeds of monocotyledonous and dicotyledonous weeds are sown in plastic pots in sandy loam soil (double sowings with one species of monocotyledonous or dicotyledonous weed per pot) and covered with soil.
  • the compounds according to the invention formulated as wettable powders (WP) or as emulsion concentrates (EC), are then applied to the surface of the cover soil as an aqueous suspension or emulsion, with the addition of 0.5% additive, at a water volume of approximately 600 liters per hectare. After treatment, the pots are placed in greenhouse 25 and kept under good growing conditions for the test plants.
  • WP wettable powders
  • EC emulsion concentrates
  • Table B1 Pre-emergence efficacy at an application rate of 1280 g/ha against ABUTH in % ⁇
  • Table B2 Pre-emergence efficacy at an application rate of 1280 or 320 g/ha against ALOMY in % ⁇ 5
  • Table B3a Pre-emergence efficacy at an application rate of 1280 g/ha against DIGSA in %
  • Table B3b Pre-emergence efficacy at an application rate of 320 g/ha against DIGSA in % BCS241005-Abroad STR 286
  • Table B3c Pre-emergence efficacy at an application rate of 80 g/ha against DIGSA in % ⁇
  • Table B4a Pre-emergence efficacy at an application rate of 1280 g/ha against ECHCG in % 5
  • Table B4b Pre-emergence efficacy at an application rate of 320 g/ha against ECHCG in %
  • Table B5a Pre-emergence efficacy at an application rate of 1280 g/ha against ECH
  • Table B7b Pre-emergence efficacy at an application rate of 320 g/ha against POAAN in %
  • Table B7c Pre-emergence efficacy at an application rate of 80 g/ha against POAAN in % BCS241005-Abroad STR 289
  • Table B8a Pre-emergence efficacy at an application rate of 1280 g/ha against SETVI in % ⁇
  • Table B8b Pre-emergence efficacy at an application rate of 320 g/ha against SETVI in % 5
  • Table B8c Pre-emergence efficacy at an application rate of 80 g/ha against SETVI in %
  • Table B9a Pre-emergence efficacy at an application rate of 1280 g/ha against STEME in % BCS241005-Abroad STR 290
  • Table B9b Pre-emergence efficacy at an application rate of 320 g/ha against STEME in % ⁇
  • Table B10 Pre-emergence efficacy at an application rate of 1280 g/
  • I.1-6, I.1-21, I.1-29 and other compounds from Tables B1-B12 exhibit good herbicidal efficacy against weeds when applied pre-emergence.
  • compounds Nos. I.1-6, I.1-21, and I.1-29 show very good herbicidal activity (80% to 100% herbicidal efficacy) against weeds such as Abutilon theophrasti, Amaranthus retroflexus, Echinochloa crus-galli, Matricaria inodora, Poa annua, Setaria viridis, and Stellaria media when applied on emergence at an application rate of 1.28 kg/ha.
  • compounds Nos. I.1-6, I.1-21, I.1-22, and I.1-29 show very good herbicidal activity (80% to 100% herbicidal efficacy) against weeds such as Abutilon theophrasti, Amaranthus retroflexus, Matricaria inodora, Poa annua, and Stellaria media when applied post-emergence at an application rate of 10 to 1.28 kg of active substance or less per hectare.
  • Pre-emergence herbicide activity – Part II 15 Seeds of monocot and dicot weeds were placed in plastic or organic plant pots and covered with soil.
  • the compounds according to the invention formulated as wettable powders (WP) or as emulsion concentrates (EC), were then applied to the surface of the cover soil as an aqueous suspension or emulsion with the addition of 0.5% additive and a water volume equivalent to 600 l/ha. After treatment, the 20 pots were placed in the greenhouse and kept under good growing conditions for the test plants. After approximately 3 weeks, the effect of the preparations was visually assessed in comparison to untreated controls as a percentage. For example, 100% effect means plants have died, 0% effect means the same as the control plants.
  • Table D1a Pre-emergence efficacy at an application rate of 1280 g/ha against ABUTH in % ⁇ Table D1b: Pre-emergence efficacy at an application rate of 320 g/ha against ABUTH in % 5
  • Table D2a Pre-emergence efficacy at an application rate of 1280 g/ha against ALOMY in % BCS241005-Abroad STR 298
  • Table D2b Pre-emergence efficacy at an application rate of 320 g/ha against ALOMY in %
  • Table D2c Pre-emergence efficacy against ALOMY at an application rate of 80 g/ha in % BCS241005-Abroad STR 299
  • Table D3a Pre-emergence efficacy at an application rate of 1280 g/ha against AMARE in %
  • Table D3b Pre-emergence efficacy at an application rate of 320 g/ha against AMARE in % BCS241005-Abroad STR 300 ⁇ Table D
  • Tables E1 to E4 below show the effects of selected compounds of the 5 general formula (I) according to Table I.1 on various crops at application rates of 1280 g/ha and below, obtained according to the aforementioned trial procedure.
  • Table E1a Pre-emergence effect at 1280 g/ha on ZEAMX in % BCS241005-Abroad STR 318
  • Table E1b Pre-emergence effect at 320 g/ha on ZEAMX in % BCS241005-Abroad STR 319
  • Table E1c Pre-emergence effect at 80 g/ha on ZEAMX in % BCS241005-Abroad STR 320
  • Table E2a Pre-emergence effect at 1280 g/ha on TRZAS in % BCS241005-Abroad STR 321
  • Table E2b Pre-emergence effect at 320 g/ha on TRZAS in % BCS241005-Abroad STR 322
  • Table E2c Pre-emergence effect at 80 g/ha on TRZAS in
  • Tables F1 to F15 below show the effects of selected compounds of the general formula (I) according to Table I.1 on various weeds at application rates of 1280 g/ha and lower, obtained according to the aforementioned experimental procedure.
  • Tables F1 to F15 below show the effects of selected compounds of the general formula (I) according to Table I.1 on various weeds at application rates of 1280 g/ha and lower, obtained according to the aforementioned experimental procedure.
  • Table F1a Post-emergence efficacy at an application rate of 1280 g/ha against ABUTH in %
  • Table F1b Post-emergence efficacy at an application rate of 320 g/ha against ABUTH in % BCS241005-Abroad STR 332
  • Table F1c Post-emergence efficacy at an application rate of 80 g/ha against ABUTH in % ⁇
  • Table F1d Post-emergence efficacy at an application rate of 20 g/ha against ABUTH in % 5
  • Table F1e Post-emergence efficacy at an application rate of 5 g/ha against ABUTH in %
  • Table F1f Post-emergence efficacy at an application rate of 1.25 g/ha against ABUTH in %
  • Table F2a Post-emergence efficacy at an application rate of 1280 g/ha against ALOMY in % BCS241005-Abroad STR 333 ⁇
  • Table F2b Post-emergence efficacy at an application rate
  • Table G1a Post-emergence effect at 1280 g/ha on ZEAMX in % 30 BCS241005-Abroad STR 353 BCS241005-Abroad STR 354
  • Table G1b Post-emergence effect at 320 g/ha on ZEAMX in % BCS241005-Abroad STR 355
  • Table G1c Post-emergence effect at 80 g/ha on ZEAMX in % BCS241005-Abroad STR 356 ⁇
  • Table G1d Post-emergence effect at 20 g/ha on ZEAMX in % 5
  • Table G1e Post-emergence effect at 5 g/ha on ZEAMX in % BCS241005-Abroad STR 357
  • Table G1f Post-emergence effect at 1.25 g/ha on ZEAMX in % ⁇ 5
  • Table G2a Post-emergence effect at 1280 g/ha on TRZAS in % BCS241005-Abroad STR 358
  • Table G2b Post-emergence effect at
  • the mortality is determined as a percentage. 100% means that all aphids were killed, and 0% means that no aphids were killed. In this test, for example, the following compounds from the preparation examples showed a good efficacy of 100% at an application rate of 100 ppm: I.1-48, I.2-27.
  • Myzus persicae - Oral test Solvent 100 parts by weight acetone. To prepare a suitable active ingredient preparation, 1 part by weight of the active ingredient is mixed with the specified amount of solvent, and the concentrate is diluted with water to the desired concentration.
  • Containers are filled with sand, a solution of the active ingredient, a suspension containing eggs and larvae of the southern root-knot nematode (Meloidogyne incognita), and lettuce seeds.
  • the lettuce seeds germinate, and the seedlings grow. Galls develop on the roots. After 14 days, the nematicidal effect is determined as a percentage based on gall formation. 100% means that no galls were found, and 0% means that the number of galls found on the roots of the 30 treated plants was equal to the number found on the untreated control plants.
  • the following compounds from the manufacturing examples showed a good effect of 90% at an application rate of 20 ppm: I.1-52. ⁇

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Abstract

The present invention relates to substituted arylprazines and salts thereof according to formula (I), to methods for the production thereof, and to the use thereof as herbicides, in particular for controlling weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants.

Description

BCS241005-Ausland STR 1 Bayer AG Substituierte Arylpyrazine sowie deren Salze und ihre Verwendung als herbizide Wirkstoffe 5 Beschreibung Die Erfindung betrifft das technische Gebiet der Pflanzenschutzmittel, insbesondere das der Herbizide zur selektiven Bekämpfung von Unkräutern und Ungräsern in Nutzpflanzenkulturen. 10 Speziell betrifft diese Erfindung substituierte Arylpyrazine sowie deren Salze, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide, insbesondere zur Bekämpfung von Unkräutern und/oder Ungräsern in Nutzpflanzenkulturen und/oder als Pflanzenwachstumsregulatoren zur Beeinflussung des Wachstums von Nutzpflanzenkulturen. 15 Bisher bekannte Pflanzenschutzmittel zur selektiven Bekämpfung von Schadpflanzen in Nutzpflanzenkulturen oder Wirkstoffe zur Bekämpfung von unerwünschtem Pflanzenwuchs weisen bei ihrer Anwendung teilweise Nachteile auf, sei es, dass sie (a) keine oder aber eine unzureichende herbizide Wirkung gegen bestimmte Schadpflanzen, (b) ein zu geringes Spektrum der Schadpflanzen, das mit einem Wirkstoff bekämpft werden kann, (c) eine zu geringe Selektivität in Nutzpflanzenkulturen 20 und/oder (d) ein toxikologisch ungünstiges Profil besitzen. Weiterhin führen manche Wirkstoffe, die als Pflanzenwachstumsregulatoren bei einigen Nutzpflanzen eingesetzt werden können, bei anderen Nutzpflanzen zu unerwünscht verminderten Ernteerträgen oder sind mit der Kulturpflanze nicht oder nur in einem engen Aufwandmengenbereich verträglich. Einige der bekannten Wirkstoffe lassen sich wegen schwer zugänglicher Vorprodukte und Reagenzien im industriellen Maßstab nicht wirtschaftlich 25 herstellen oder besitzen nur unzureichende chemische Stabilitäten. Bei anderen Wirkstoffen hängt die Wirkung zu stark von Umweltbedingungen, wie Wetter- und Bodenverhältnissen ab. Die herbizide Wirkung dieser bekannten Verbindungen, insbesondere bei niedrigen Aufwandmengen, bzw. deren Verträglichkeit gegenüber Kulturpflanzen bleiben verbesserungswürdig. 30 Es ist aus verschiedenen Schriften bekannt, dass bestimmte substituierte Heteroaryltriazole und Heteroaryltetrazole als Wirkstoffe gegen Ectoparasiten in Tieren oder gegen Insekten zur Verhinderung von Fraßschäden in Kulturpflanzen verwendet werden können (vgl. WO2017/192385, WO 2019/170626 and WO 2019/215198). Weitere Heteroaryltriazole und Heteroaryltetrazole sowie ihre insektizide Wirkung bei der Anwendung auf Kulturpflanzen sind ebenfalls beschrieben (vgl. WO 2019/201835, 35 WO 2019/197468, WO 2019/202077, WO 2019/206799, WO 2023/037249). BCS241005-Ausland STR 2 Es ist weiterhin bekannt, dass bestimmte Azolamide auch als insektizide Wirkstoffe eingesetzt werden können (WO2020/002563, WO2020/053364, WO2020/053365, WO2020/079198). Es ist darüber hinaus bekannt, dass substituierte Heteroaryloxazole und Heteroarylthiazole ebenfalls insektizide Wirkungen zeigen (vgl. WO2023/110473). 5 Es ist zwar ebenfalls bekannt, dass substituierte Heteroarylpyrazine als insektizide Wirkstoffe verwendet werden können (vgl. WO2020/201079; WO2020/208036, WO2020/201398, WO2021/069575, WO2021/068179, WO2022/258481). Substituierte N-(Arylpyrazinylalkyl)carboxamide mit herbizider Wirkung sind dagegen noch nicht beschrieben. Zwar sind weiterhin substituierte Arylchinoxaline und10 ihre Verwendung als PI3 Kinaseinhibitoren (vgl. WO2016/054491) beschrieben, substituierte N- (Arylpyrazinylalkyl)carboxamide mit substituierten Pyrazinylbenzoesäuregruppen sind dagegen noch nicht beschrieben. Überraschenderweise wurde nun gefunden, dass bestimmte substituierte Arylpyrazine oder deren Salze 15 als Herbizide gut geeignet sind und besonders vorteilhaft als Wirkstoffe zur Bekämpfung von monokotylen und dikotylen Unkräutern in Nutzpflanzenkulturen eingesetzt werden können. Ein Gegenstand der vorliegenden Erfindung sind damit substituierte Arylpyrazine der allgemeinen Formel (I) oder deren Salze, 20 worin M für eine der Gruppen M-1 M-2 M-3 25 steht, wobei die gestrichelte Linie die Verknüpfungsstelle zum restlichen Teil der Formel (I) kennzeichnet, BCS241005-Ausland STR 3 R1 für Aryl oder Heteroaryl steht, wobei die Aryl- oder Heteroarylgruppe gegebenenfalls weiter substituiert ist durch 1, 2 oder 3 an Ringkohlenstoffatomen gebundene und unabhängig voneinander gewählte 5 Substituenten R4, und wobei gegebenenfalls jeweils zwei benachbarte Substituenten R4 mit den Ringkohlenstoffatomen, an die sie gebunden sind, einen gesättigten, teilgesättigten oder ungesättigten 5- bis 7-gliedrigen, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten Ring bilden können, 10 oder R1 steht für einen fünf- oder sechsgliedrigen Heterocyclyl, der gesättigt oder teilweise gesättigt sein kann, der ein bis vier Heteroatome enthalten kann und der n Oxogruppen trägt, wobei jedes Heteroatom unabhängig voneinander aus einer Gruppe bestehend aus Sauerstoff, Stickstoff und Schwefel gewählt ist, und wobei der Heterocyclylrest optional substituiert ist 15 durch einen, zwei oder drei Substituenten, welche unabhängig voneinander gewählt sind aus einer Gruppe (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C1-C6)-Cycloalkyl, (C1-C6)-Alkoxy, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkoxy, Halogen, Aryl, Heteroaryl, (Heterocyclyl)aryl, 20 R2 für Wasserstoff, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C1-C8)-Cyanoalkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C2-C8)-Alkenyl, (C2-C8)-Haloalkenyl, (C2-C8)-Alkinyl, (C2-C8)-Haloalkinyl, NR11R12, S(O)R14, SO2R14, C(O)OR13, C(O)R13 oder für Aryl-(C1-C8)-alkyl, wobei die Arylgruppe gegebenenfalls weiter 1 bis 5 Substituenten trägt, die unabhängig voneinander für Halogen, Cyano, Nitro, Trimethylsilyl, Pentafluorsulfanyl, -C(=S)NH2, OR13, NR11R12, SR14,25 S(O)R14, SO2R14, C(O)OR13, C(O)R13, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C2-C8)-Alkenyl, (C2-C8)-Haloalkenyl, (C2-C8)-Alkinyl, (C2-C8)-Haloalkinyl, (C3- C8)-Cycanocycloalkyl, (C3-C6)-Halocycloalkyl, (C1-C8)-Haloalkyl, (C1-C8)-Cyanoalkyl steht, oder für Heteroaryl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl steht und wobei Heterocyclyl n Oxogruppen trägt, 30 R3 für (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C2-C8)-Alkenyl, R13O-(C1-C8)-alkyl, (C3-C8)- Cycloalkyl-(C1-C8)-alkyl steht, R4 für Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorsulfanyl, Nitro, Aryldiazo,35 NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1-C8)-alkyl, OSO2-(C1-C8)-haloalkyl, OSO2-(C3-C8)-cycloalkyl, C(O)OR13, C(O)R13, C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C8)-alkyl, R13O-(C1-C8)-alkyl, R14S-(C1- BCS241005-Ausland STR 4 C8)-alkyl, R13(O)C-(C1-C8)-alkyl, (C1-C8)-Alkyl, Cyano-(C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2- C8)-Alkinyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C2-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)- Haloalkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, 5 (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-haloalkyl, (C4-C10)-Cycloalkenyl- (C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C8)- alkyl, Aryl-(C1-C8)-alkinyl, Heteroaryl-(C1-C8)-alkinyl, Heterocyclyl-(C1-C8)-alkinyl, Tris-[(C1- C8)-alkyl]silyl-(C2-C8)-alkinyl, Bis-[(C1-C8)-alkyl](aryl)silyl-(C2-C8)-alkinyl, Bis-aryl[(C1-C8)- alkyl]silyl-(C2-C8)-alkinyl, (C3-C8)-Cycloalkyl-(C2-C8)-alkinyl, Aryl-(C2-C8)-alkenyl, 10 Heteroaryl-(C2-C8)-alkenyl, Heterocyclyl-(C2-C8)-alkenyl, (C3-C8)-Cycloalkyl-(C2-C8)-alkenyl, Cyano-(C3-C8)-cycloalkylaminosulfonylamino, Tris-[(C1-C8)-alkyl]silyl, Bis-[(C1-C8)- alkyl](aryl)silyl, Bis-aryl[(C1-C8)-alkyl]silyl steht, wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und 15 (C1-C8)-Alkylsulfonyl und wobei Aryl- oder Heteroarylgruppen durch ein oder zwei Alkoxycarbonylgruppen substituiert sein können, R5, R6 unabhängig voneinander für Wasserstoff, Halogen, Cyano, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Halocycloalkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, R13O-(C1-C8)- 20 alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, -C=NOR13 stehen, R7 für Wasserstoff, Halogen, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C1-C8)-Alkoxy, (C1-C8)- Haloalkoxy, (C1-C8)-Haloalkyl steht, 25 Q für Hydroxy oder einen Rest der nachfolgenden Formeln Q-1 Q-2 steht, R8 für Wasserstoff, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, 30 (C2-C8)-Alkinyl, (C2-C8)-Alkenyl, C(O)R13, C(O)OR13, (C1-C8)-Alkoxy-(C1-C8)-alkyl steht, R9 für Wasserstoff oder (C1-C8)-Alkyl steht, BCS241005-Ausland STR 5 R10 für Wasserstoff, Halogen, Cyano, NO2, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C3-C8)-Halocycloalkyl, (C3-C8)-Halocycloalkyl-(C1-C8)- alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1- C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, R11R12N-(C1-C8)-alkyl, R13O-(C1-C8)-alkyl, 5 Cyano-(C1-C8)-alkyl, (C1-C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl- carbonyloxy-(C1-C8)-alkyl, Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy-(C1-C8)- alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- C8)-alkyl, R14(O)S-(C1-C8)-alkyl, R14O2S-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis-[(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, Tris- 10 [(C1-C8)-Alkyl]silyl, Bis-hydroxyboryl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkoxy]boryl-(C1-C8)-alkyl, Tetramethyl-1,3,2-Dioxaborolan-2-yl, Tetramethyl-1,3,2-Dioxaborolan-2-yl-(C1-C8)-alkyl, Nitro-(C1-C8)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1C8)-alkyl, R11R12N(O)C- (C1-C8)-alkyl, Bis-(C1-C8)-alkoxy-(C1-C8)-alkyl steht, wobei Heterocyclyl n Oxogruppen trägt, oder 15 R8 und R10 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, 20 R11 und R12 gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4- C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1- C8)-Alkylthio-(C1-C8)-alkyl, (C1-C8)-Haloalkylthio-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-25 haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C8)- Alkoxycarbonyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-amino- carbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)- alkoxycarbonyl, Heteroaryl-(C1-C8)-alkoxycarbonyl, (C2-C8)-Alkenyloxycarbonyl, (C2-C8)- 30 Alkinyloxycarbonyl, Heterocyclyl-(C1-C8)-alkyl stehen, wobei Heterocyclyl n Oxogruppen trägt, oder R11 und R12 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch weitere Heteroatome unterbrochenen und gegebenenfalls 35 weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, BCS241005-Ausland STR 6 R13 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C4-C10)- Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy- (C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, 5 (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy- (C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, Aryl, Aryl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxy- (C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl- aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Bis-[(C1-C8)-10 alkyl]amino-(C2-C6)-alkyl, (C1-C8)-Alkyl-amino-(C2C6)-alkyl, Aryl-(C1-C8)-alkylamino-(C2-C6)- alkyl, R14S-(C1-C8)-alkyl, R14(O)S-(C1-C8)-alkyl, R14O2S-(C1-C8)-alkyl, Hydroxycarbonyl-(C1- C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis-[(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, (C1- C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkylcarbonyloxy-(C1-C8)-alkyl, 15 Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy-(C1-C8)-alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, Aryloxy-(C1-C8)-alkyl, Heteroaryloxy-(C1-C8)-alkyl, (C1-C8)-Alkoxycarbonyl steht, wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1-C8)- 20 Alkylsulfonyl, R14 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)- Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-25 (C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl, (C3-C8)- Cycloalkyl-(C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, Amino, Bis-[(C1-C8)- alkyl]amino, (C1-C8)-Alkyl-amino, Aryl-(C1-C8)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1- C8)-alkyl]amino, (C3-C8)-Cycloalkyl-amino, (C3-C8)-Cycloalkyl-[(C1-C8)-alkyl]amino, N- Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl steht, 30 wobei die zwölf letztgenannten Reste (d.h. Amino, Bis-[(C1-C8)-alkyl]amino, (C1-C8)- Alkyl-amino, Aryl-(C1-C8)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C8)-alkyl]amino, (C3- C8)-Cycloalkyl-amino, (C3-C8)-Cycloalkyl-[(C1-C8)-alkyl]amino, N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl) nur an Sulfonylgruppen gebunden sind, und wobei Heterocyclyl n Oxogruppen trägt, 35 und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1-C8)-Alkylsulfonyl, BCS241005-Ausland STR 7 R15 und R16 unabhängig voneinander für (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, Aryl, Heteroaryl, Heterocyclyl stehen, wobei Heterocyclyl n Oxogruppen trägt, oder 5 R15 und R16 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten monocyclischen 3- bis 7-gliedrigen Carbocyclus bilden, R17, R18, R19 und R20 unabhängig voneinander für Wasserstoff, Halogen, (C1-C8)-Alkyl, (C1-C8)-Alkoxy, (C1-C8)-Haloalkoxy, (C3-C8)-Cycloalkyl, (C1-C8)-Haloalkyl stehen, 10 und n für 0, 1 oder 2 steht. 15 Die Verbindungen der allgemeinen Formel (I) können durch Anlagerung einer geeigneten anorganischen oder organischen Säure, wie beispielsweise Mineralsäuren, wie beispielsweise HCl, HBr, H2SO4, H3PO4 oder HNO3, oder organische Säuren, z. B. Carbonsäuren, wie Ameisensäure, Essigsäure, Propionsäure, Oxalsäure, Milchsäure oder Salicylsäure oder Sulfonsäuren, wie zum Beispiel p- Toluolsulfonsäure, an eine basische Gruppe, wie z.B. Amino, Alkylamino, Dialkylamino, Piperidino, 20 Morpholino oder Pyridino, Salze bilden. Diese Salze enthalten dann die konjugierte Base der Säure als Anion. Geeignete Substituenten, die in deprotonierter Form, wie z.B. Sulfonsäuren, bestimmte Sulfonsäureamide oder Carbonsäuren, vorliegen, können innere Salze mit ihrerseits protonierbaren Gruppen, wie Aminogruppen bilden. Salzbildung kann auch durch Einwirkung einer Base auf Verbindungen der allgemeinen Formel (I) erfolgen. Geeignete Basen sind beispielsweise organische 25 Amine, wie Trialkylamine, Morpholin, Piperidin und Pyridin sowie Ammonium-, Alkali- oder Erdalkalimetallhydroxide, -carbonate und -hydrogencarbonate, insbesondere Natrium- und Kaliumhydroxid, Natrium- und Kaliumcarbonat und Natrium- und Kaliumhydrogencarbonat. Diese Salze sind Verbindungen, in denen der acide Wasserstoff durch ein für die Landwirtschaft geeignetes Kation ersetzt wird, beispielsweise Metallsalze, insbesondere Alkalimetall-salze oder 30 Erdalkalimetallsalze, insbesondere Natrium- und Kaliumsalze, oder auch Ammoniumsalze, Salze mit organischen Aminen oder quartäre Ammoniumsalze, zum Beispiel mit Kationen der Formel [NRaRbRcRd]+, worin Ra bis Rd jeweils unabhängig voneinander einen organischen Rest, insbesondere Alkyl, Aryl, Aralkyl oder Alkylaryl darstellen. Infrage kommen auch Alkylsulfonium- und Alkylsulfoxoniumsalze, wie (C1-C4)-Trialkylsulfonium- und (C1-C4)-Trialkylsulfoxoniumsalze. 35 Die Verbindungen der allgemeinen Formel (I) können je nach Art und Verknüpfung der Substituenten als Stereoisomere vorliegen. Die durch ihre spezifische Raumform definierten möglichen Stereoisomere, BCS241005-Ausland STR 8 wie Enantiomere, Diastereomere, Z- und E-Isomere sind alle von der Formel (I) umfasst. Sind beispielsweise eine oder mehrere Alkenylgruppen vorhanden, so können Diastereomere (Z- und E- Isomere) auftreten. Sind beispielsweise ein oder mehrere asymmetrisch substituierte Kohlenstoffatome vorhanden, so können Enantiomere und Diastereomere auftreten. Stereoisomere lassen sich aus den bei 5 der Herstellung anfallenden Gemischen nach üblichen Trennmethoden erhalten. Die chromatographische Trennung kann sowohl im analytischen Maßstab zur Feststellung des Enantiomerenüberschusses bzw. des Diastereomerenüberschusses, wie auch im präparativen Maßstab zur Herstellung von Prüfmustern für die biologische Ausprüfung erfolgen. Ebenso können Stereoisomere durch Einsatz stereoselektiver Reaktionen unter Verwendung optisch aktiver Ausgangs- 10 und/oder Hilfsstoffe selektiv hergestellt werden. Die Erfindung betrifft somit auch alle Stereoisomeren, die von der allgemeinen Formel (I) umfasst, jedoch nicht mit ihrer spezifischen Stereoform angegeben sind, sowie deren Gemische. Getrennte Enantiomere, die von der allgemeinen Formel (I) umfasst sind, werden entweder (a) entsprechend ihrer optischen Aktivität mit (+)- und (- )gekennzeichnet, d.h. solche Isomere, die planpolarisiertes Licht im Uhrzeigersinn ((+)-Richtung) drehen, werden mit "(+)" 15 bezeichnet; (b) entsprechend der Cahn-Ingold-Prelog Regeln in R- und S-Enantiomere eingeteilt oder (c) entsprechend ihrer Retentionszeit bei der Trennung mittels chiraler Chromatographie mit „Ent-1“ und „Ent-2“ gekennzeichnet. Verfahren zur Trennung von Enantiomeren sind im Stand der Technik gut bekannt, z.B. die Trennung mittels chiraler Chromatographie. 20 Sofern die Verbindungen als Feststoffe erhalten werden, kann die Reinigung auch durch Umkristallisieren oder Digerieren erfolgen. Einzelne Verbindungen (I) können auch durch Derivatisierung anderer Verbindungen (I) hergestellt werden. Als Isolierungs-, Reinigungs- und Stereoisomerenauftrennungsverfahren von Verbindungen der Formel 25 (I) kommen Methoden in Frage, die dem Fachmann aus analogen Fällen allgemein bekannt sind, z.B. durch physikalische Verfahren wie Kristallisation, Chromatographieverfahren, vor allem Säulenchromatographie und HPLC (Hochdruckflüssigchromatographie), Destillation, gegebenenfalls unter reduziertem Druck, Extraktion und andere Verfahren, können gegebenenfalls verbleibende Gemische in der Regel durch chromatographische Trennung, z.B. an chiralen Festphasen, getrennt 30 werden. Für präparative Mengen oder im industriellen Maßstab kommen Verfahren in Frage wie Kristallisation, z.B. diastereomerer Salze, die aus den Diastereomerengemischen mit optisch aktiven Säuren und gegebenenfalls bei vorhandenen sauren Gruppen mit optisch aktiven Basen erhalten werden können. 35 Im Folgenden werden die erfindungsgemäß verwendeten Verbindungen der Formel (I) und ihre Salze "Verbindungen der allgemeinen Formel (I)" bezeichnet. BCS241005-Ausland STR 9 Bevorzugter Erfindungsgegenstand sind Verbindungen der allgemeinen Formel (I), worin M für eine der Gruppen M-1 M-2 M-3 5 steht, wobei die gestrichelte Linie die Verknüpfungsstelle zum restlichen Teil der Formel (I) kennzeichnet, R1 für Aryl oder Heteroaryl steht, 10 wobei die Aryl- oder Heteroarylgruppe gegebenenfalls weiter substituiert ist durch 1, 2 oder 3 an Ringkohlenstoffatomen gebundene und unabhängig voneinander gewählte Substituenten R4, und wobei gegebenenfalls jeweils zwei benachbarte Substituenten R4 mit den Ringkohlenstoffatomen, an die sie gebunden sind, einen gesättigten, teilgesättigten oder 15 ungesättigten 5- bis 7-gliedrigen, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten Ring bilden können, oder R1 steht für einen fünf- oder sechsgliedrigen Heterocyclyl, der gesättigt oder teilweise gesättigt sein kann, der ein bis vier Heteroatome enthalten kann und der n Oxogruppen trägt, 20 wobei jedes Heteroatom unabhängig voneinander aus einer Gruppe bestehend aus Sauerstoff, Stickstoff und Schwefel gewählt ist, und wobei der Heterocyclylrest optional substituiert ist durch einen, zwei oder drei Substituenten, welche unabhängig voneinander gewählt sind aus einer Gruppe (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C1-C6)-Cycloalkyl, (C1-C6)-Alkoxy, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkoxy, Halogen, Aryl, Heteroaryl, 25 (Heterocyclyl)aryl; R2 für Wasserstoff, (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C1-C7)-Cyanoalkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C2-C7)-Alkenyl, (C2-C7)-Haloalkenyl, (C2-C7)-Alkinyl, (C2-C7)-Haloalkinyl, NR11R12, S(O)R14, SO2R14, C(O)OR13, C(O)R13 oder für Aryl-(C1-C7)-alkyl, wobei die 30 Arylgruppe gegebenenfalls weiter 1 bis 5 Substituenten trägt, die unabhängig voneinander für Halogen, Cyano, Nitro, Trimethylsilyl, Pentafluorsulfanyl, -C(=S)NH2, OR13, NR11R12, SR14, S(O)R14, SO2R14, C(O)OR13, C(O)R13, (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Cycloalkyl- BCS241005-Ausland STR 10 (C1-C7)-alkyl, (C2-C7)-Alkenyl, (C2-C7)-Haloalkenyl, (C2-C7)-Alkinyl, (C2-C7)-Haloalkinyl, (C3- C7)-Cycanocycloalkyl, (C3-C7)-Halocycloalkyl, (C1-C7)-Haloalkyl, (C1-C7)-Cyanoalkyl stehen, oder für Heteroaryl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkyl steht und wobei Heterocyclyl n Oxogruppen trägt, 5 R3 für (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C2-C7)-Alkenyl, R13O-(C1-C7)-alkyl, (C3-C7)- Cycloalkyl-(C1-C7)-alkyl steht, R4 für Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorsulfanyl, Nitro, Aryldiazo,10 NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1-C7)-alkyl, OSO2-(C1-C7)-haloalkyl, OSO2-(C3-C7)-cycloalkyl, C(O)OR13, C(O)R13 C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C7)-alkyl, R13O-(C1-C7)-alkyl, R13S-(C1- C7)-alkyl, R13(O)C-(C1-C7)-alkyl, (C1-C7)-Alkyl, Cyano-(C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2- C7)-Alkinyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C2-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl,15 (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)- Haloalkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-haloalkyl, (C4-C7)-Cycloalkenyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C7)- alkyl, Aryl-(C1-C7)-alkinyl, Heteroaryl-(C1-C7)-alkinyl, Heterocyclyl-(C1-C7)-alkinyl, Tris-[(C1-20 C7)-alkyl]silyl-(C2-C7)-alkinyl, Bis-[(C1-C7)-alkyl](aryl)silyl-(C2-C7)-alkinyl, Bis-aryl[(C1-C7)- alkyl]silyl-(C2-C7)-alkinyl, (C3-C7)-Cycloalkyl-(C2-C7)-alkinyl, Aryl-(C2-C7)-alkenyl, Heteroaryl-(C2-C7)-alkenyl, Heterocyclyl-(C2-C7)-alkenyl, (C3-C7)-Cycloalkyl-(C2-C7)-alkenyl, Cyano-(C3-C7)-Cycloalkylaminosulfonylamino, Tris-[(C1-C7)-alkyl]silyl, Bis-[(C1-C7)- alkyl](aryl)silyl, Bis-aryl[(C1-C7)-alkyl]silyl steht und wobei Heterocyclyl n Oxogruppen trägt 25 und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1-C8)-Alkylsulfonyl und wobei Aryl- oder Heteroarylgruppen durch ein oder zwei Alkoxycarbonylgruppen substituiert sein können, 30 R5, R6 unabhängig voneinander für Wasserstoff, Halogen, Cyano, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, R13O-(C1-C7)- alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, -C=NOR13 stehen, 35 R7 für Wasserstoff, Halogen, (C1-C7)-Alkyl, (C1-C7)-Alkoxy, (C1-C7)-Haloalkoxy, (C3-C7)- Cycloalkyl, (C1-C7)-Haloalkyl steht, BCS241005-Ausland STR 11 Q für Hydroxy oder einen Rest der nachfolgenden Formeln Q-1 Q-2 steht, R8 für Wasserstoff, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, 5 (C2-C7)-Alkinyl, (C2-C7)-Alkenyl, C(O)R13, C(O)OR13, (C1-C7)-Alkoxy-(C1-C7)-alkyl steht, R9 für Wasserstoff oder (C1-C7)-Alkyl steht, R10 für Wasserstoff, Halogen, Cyano, NO2, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl,10 (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C3-C7)-Halocycloalkyl, (C3-C7)-Halocycloalkyl-(C1-C7)- alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1- C7)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-alkyl, R11R12N-(C1-C7)-alkyl, R13O-(C1-C7)-alkyl, Cyano-(C1-C7)-alkyl, (C1-C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- carbonyloxy-(C1-C7)-alkyl, Arylcarbonyloxy-(C1-C7)-alkyl, Heteroarylcarbonyloxy-(C1-C7)-15 alkyl, Heterocyclylcarbonyloxy-(C1-C7)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- C7)-alkyl, R14(O)S-(C1-C7)-alkyl, R14O2S-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, Tris- [(C1-C7)-Alkyl]silyl, Bis-hydroxyboryl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkoxy]boryl-(C1-C7)-alkyl, Tetramethyl-1,3,2-Dioxaborolan-2-yl, Tetramethyl-1,3,2-Dioxaborolan-2-yl-(C1-C7)-alkyl,20 Nitro-(C1-C7)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1-C7)-alkyl, R11R12N(O)C- (C1-C7)-alkyl, Bis-(C1-C7)-alkoxy-(C1-C7)-alkyl steht und wobei Heterocyclyl n Oxogruppen trägt, oder R8 und R10 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder 25 teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R11 und R12 gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl,30 (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4- C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1- C7)-Alkylthio-(C1-C7)-alkyl, (C1-C7)-Haloalkylthio-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)- haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C7)- BCS241005-Ausland STR 12 Alkoxycarbonyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl-amino- carbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)- alkoxycarbonyl, Heteroaryl-(C1-C7)-alkoxycarbonyl, (C2-C7)-Alkenyloxycarbonyl, (C2-C7)- Alkinyloxycarbonyl, Heterocyclyl-(C1-C7)-alkyl stehen und wobei Heterocyclyl n Oxogruppen 5 trägt, oder R11 und R12 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, 10 R13 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)- Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-15 Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)- alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, Aryl, Aryl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxy-(C1-C7)- alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C7)- Cycloalkenyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl- aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, Bis-[(C1-C7)-20 alkyl]amino-(C2-C6)-alkyl, (C1-C7)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C7)-alkyl-amino-(C2- C6)-alkyl, R14S-(C1-C7)-alkyl, R14(O)S-(C1-C7)-alkyl, R14O2S-(C1-C7)-alkyl, Hydroxycarbonyl- (C1-C7)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, (C1- C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkylcarbonyloxy-(C1-C7)-alkyl, 25 Arylcarbonyloxy-(C1-C7)-alkyl, Heteroarylcarbonyloxy-(C1-C7)-alkyl, Heterocyclylcarbonyloxy-(C1-C7)-alkyl, Aryloxy-(C1-C7)-alkyl, Heteroaryloxy-(C1-C7)-alkyl, (C1-C7)-Alkoxycarbonyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1- 30 C8)-Alkylsulfonyl, R14 für (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)- Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-35 (C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkyl, (C3-C7)- Cycloalkyl-(C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, Amino, Bis-[(C1-C7)- alkyl]amino, (C1-C7)-Alkyl-amino, Aryl-(C1-C7)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1- BCS241005-Ausland STR 13 C7)-alkyl]amino; (C3-C7)-Cycloalkyl-amino, (C3-C7)-Cycloalkyl-[(C1-C7)-alkyl]amino, N- Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl steht, wobei die zwölf letztgenannten Reste nur an Sulfonylgruppen gebunden sind und wobei Heterocyclyl n Oxogruppen trägt, und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus 5 einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1-C8)-Alkylsulfonyl, R15 und R16 unabhängig voneinander für (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, Aryl, Heteroaryl, Heterocyclyl stehen und wobei Heterocyclyl n Oxogruppen trägt, oder 10 R15 und R16 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten monocyclischen 3- bis 7-gliedrigen Carbocyclus bilden, R17, R18, R19 und R20 unabhängig voneinander für Wasserstoff, Halogen, (C1-C7)-Alkyl, (C1-C7)-Alkoxy, 15 (C1-C7)-Haloalkoxy, (C3-C7)-Cycloalkyl, (C1-C7)-Haloalkyl stehen und n für 0, 1 oder 2 steht. 20 Besonders bevorzugter Erfindungsgegenstand sind Verbindungen der allgemeinen Formel (I), worin M für die Gruppen M-1 M-2 M-3 25 steht, wobei die gestrichelte Linie die Verknüpfungsstelle zum restlichen Teil der Formel (I) kennzeichnet, R1 für Aryl oder Heteroaryl steht, 30 wobei die Aryl- oder Heteroarylgruppe gegebenenfalls weiter substituiert ist durch 1, 2 oder 3 an Ringkohlenstoffatomen gebundene und unabhängig voneinander gewählte Substituenten R4, BCS241005-Ausland STR 14 und wobei gegebenenfalls jeweils zwei benachbarte Substituenten R4 mit den Ringkohlenstoffatomen, an die sie gebunden sind, einen gesättigten, teilgesättigten oder ungesättigten 5- bis 7-gliedrigen, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten Ring bilden können, 5 oder R1 steht für einen fünf- oder sechsgliedrigen Heterocyclyl, der gesättigt oder teilweise gesättigt sein kann, der ein bis vier Heteroatome enthalten kann und der n Oxogruppen trägt, wobei jedes Heteroatom unabhängig voneinander aus einer Gruppe bestehend aus Sauerstoff, Stickstoff und Schwefel gewählt ist, und wobei der Heterocyclylrest optional substituiert ist 10 durch einen, zwei oder drei Substituenten, welche unabhängig voneinander gewählt sind aus einer Gruppe (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C1-C6)-Cycloalkyl, (C1-C6)-Alkoxy, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkoxy, Halogen, Aryl, Heteroaryl, (Heterocyclyl)aryl; 15 R2 für Wasserstoff steht, R3 für (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, R13O-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl steht, 20 R4 für Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorsulfanyl, Nitro, Aryldiazo, NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1-C6)-alkyl, OSO2-(C1-C6)-haloalkyl, OSO2-(C3-C6)-cycloalkyl, C(O)OR13, C(O)R13 C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, R13S-(C1- C6)-alkyl, R13(O)C-(C1-C6)-alkyl, (C1-C6)-Alkyl, Cyano-(C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2- 25 C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)- Haloalkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-haloalkyl, (C4-C6)-Cycloalkenyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-30 alkyl, Aryl-(C1-C6)-alkinyl, Heteroaryl-(C1-C6)-alkinyl, Heterocyclyl-(C1-C6)-alkinyl, Tris-[(C1- C6)-alkyl]silyl-(C2-C6)-alkinyl, Bis-[(C1-C6)-alkyl](aryl)silyl-(C2-C6)-alkinyl, Bis-aryl[(C1-C6)- alkyl]silyl-(C2-C6)-alkinyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkinyl, Aryl-(C2-C6)-alkenyl, Heteroaryl-(C2-C6)-alkenyl, Heterocyclyl-(C2-C6)-alkenyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkenyl, Cyano-(C3-C6)-Cycloalkylaminosulfonylamino, Tris-[(C1-C6)-alkyl]silyl, Bis-[(C1-C6)- 35 alkyl](aryl)silyl, Bis-aryl[(C1-C6)-alkyl]silyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl BCS241005-Ausland STR 15 und (C1-C8)-Alkylsulfonyl und wobei Aryl- oder Heteroarylgruppen durch ein oder zwei Alkoxycarbonylgruppen substituiert sein können, R5, R6 unabhängig voneinander für Wasserstoff, Halogen, (C1-C6)-Alkyl stehen, 5 R7 für Wasserstoff, Halogen, (C1-C6)-Alkyl, (C1-C7)-Alkoxy, (C1-C7)-Haloalkoxy, (C3-C6)- Cycloalkyl, (C1-C6)-Haloalkyl steht, Q für Hydroxy oder einen Rest der nachfolgenden Formeln 10 Q-1 Q-2 steht, R8 für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, (C2-C6)-Alkinyl, (C2-C6)-Alkenyl, C(O)R13, C(O)OR13, (C1-C6)-Alkoxy-(C1-C6)-alkyl steht, 15 R9 für Wasserstoff oder (C1-C6)-Alkyl steht, R10 für Wasserstoff, Halogen, Cyano, NO2, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Halocycloalkyl-(C1-C6)- alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1- 20 C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, R11R12N-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, Cyano-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- carbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)- alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- C6)-alkyl, R14(O)S-(C1-C6)-alkyl, R14O2S-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl,25 Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, Tris- [(C1-C6)-Alkyl]silyl, Bis-hydroxyboryl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkoxy]boryl-(C1-C6)-alkyl, Tetramethyl-1,3,2-Dioxaborolan-2-yl, Tetramethyl-1,3,2-Dioxaborolan-2-yl-(C1-C6)-alkyl, Nitro-(C1-C6)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1-C6)-alkyl, R11R12N(O)C- (C1-C6)-alkyl, Bis-(C1-C6)-alkoxy-(C1-C6)-alkyl steht und wobei Heterocyclyl n Oxogruppen 30 trägt, oder R8 und R10 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, BCS241005-Ausland STR 16 R11 und R12 gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4- 5 C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1- C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C6)- Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-amino-10 carbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)- alkoxycarbonyl, Heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)- Alkinyloxycarbonyl, Heterocyclyl-(C1-C6)-alkyl stehen und wobei Heterocyclyl n Oxogruppen trägt, oder 15 R11 und R12 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R13 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- 20 Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)-25 alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl- aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)- alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C6)-alkyl-amino-(C2- C6)-alkyl, R14S-(C1-C6)-alkyl, R14(O)S-(C1-C6)-alkyl, R14O2S-(C1-C6)-alkyl, Hydroxycarbonyl- 30 (C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1- C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)-alkyl, 35 (C1-C6)-Alkoxycarbonyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer BCS241005-Ausland STR 17 Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1- C8)-Alkylsulfonyl, R14 für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, 5 (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)- Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1- C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1- C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Amino, Bis- [(C1-C6)-alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino,10 Aryl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1-C6)- alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl steht, wobei die zwölf letztgenannten Reste nur an Sulfonylgruppen gebunden sind und wobei Heterocyclyl n Oxogruppen trägt, und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, 15 Halogen, Cyano, Carbamoyl und (C1-C8)-Alkylsulfonyl, R15 und R16 unabhängig voneinander für (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, Aryl, Heteroaryl, Heterocyclyl stehen und wobei Heterocyclyl n Oxogruppen trägt, oder 20 R15 und R16 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten monocyclischen 3- bis 7-gliedrigen Carbocyclus bilden, R17, R18, R19 und R20 unabhängig voneinander für Wasserstoff, Halogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy, (C1-C6)-Haloalkoxy, (C3-C6)-Cycloalkyl, (C1-C6)-Haloalkyl stehen 25 und n für 0, 1 oder 2 steht. 30 Ganz besonders bevorzugter Erfindungsgegenstand sind Verbindungen der allgemeinen Formel (I), worin M für die Gruppen BCS241005-Ausland STR 18 M-1 M-2 M-3 steht, wobei die gestrichelte Linie die Verknüpfungsstelle zum restlichen Teil der Formel (I) kennzeichnet, 5 R1 für Aryl oder Heteroaryl steht, wobei die Aryl- oder Heteroarylgruppe gegebenenfalls weiter substituiert ist durch 1, 2 oder 3 an Ringkohlenstoffatomen gebundene und unabhängig voneinander gewählte Substituenten R4, 10 und wobei gegebenenfalls jeweils zwei benachbarte Substituenten R4 mit den Ringkohlenstoffatomen, an die sie gebunden sind, einen gesättigten, teilgesättigten oder ungesättigten 5- bis 7-gliedrigen, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten Ring bilden können, 15 oder R1 steht für einen fünf- oder sechsgliedrigen Heterocyclyl, der gesättigt oder teilweise gesättigt sein kann, der ein bis vier Heteroatome enthalten kann und der n Oxogruppen trägt, wobei jedes Heteroatom unabhängig voneinander aus einer Gruppe bestehend aus Sauerstoff, Stickstoff und Schwefel gewählt ist, und wobei der Heterocyclylrest optional substituiert ist durch einen, zwei oder drei Substituenten, welche unabhängig voneinander gewählt sind aus20 einer Gruppe (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Cycloalkyl, (C1-C4)-Alkoxy, (C1-C4)- Alkoxy-(C1-C4)-alkyl, (C2-C4)-Alkenyl, (C1-C4)-Haloalkoxy, Halogen, Aryl, Heteroaryl, (Heterocyclyl)aryl; R2 für Wasserstoff steht, 25 R3 für (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, R13O-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl steht, R4 für Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorsulfanyl, Nitro, Aryldiazo,30 NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1C5)-alkyl, OSO2-(C1C5)-haloalkyl, OSO2-(C3C6)-cycloalkyl, C(O)OR13, C(O)R13, C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, R13S-(C1- BCS241005-Ausland STR 19 C6)-alkyl, R13(O)C-(C1-C6)-alkyl, (C1-C6)-Alkyl, Cyano-(C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2- C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)- Haloalkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, 5 (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-haloalkyl, (C4-C6)-Cycloalkenyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C6)- alkyl, Aryl-(C1-C6)-alkinyl, Heteroaryl-(C1-C6)-alkinyl, Heterocyclyl-(C1-C6)-alkinyl, Tris-[(C1- C6)-alkyl]silyl-(C2-C6)-alkinyl, Bis-[(C1-C6)-alkyl](aryl)silyl-(C2-C6)-alkinyl, Bis-aryl[(C1-C6)- alkyl]silyl-(C2-C6)-alkinyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkinyl, Aryl-(C2-C6)-alkenyl, 10 Heteroaryl-(C2-C6)-alkenyl, Heterocyclyl-(C2-C6)-alkenyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkenyl, Cyano-(C3-C6)-Cycloalkylaminosulfonylamino, Tris-[(C1-C6)-alkyl]silyl, Bis-[(C1-C6)- alkyl](aryl)silyl, Bis-aryl[(C1-C6)-alkyl]silyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl 15 und (C1-C8)-Alkylsulfonyl und wobei Aryl- oder Heteroarylgruppen durch ein oder zwei Alkoxycarbonylgruppen substituiert sein können, R5, R6 für Wasserstoff stehen, 20 R7 für Wasserstoff, Halogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy, (C1-C6)-Haloalkoxy, (C3-C6)- Cycloalkyl, (C1-C6)-Haloalkyl steht, Q für Hydroxy oder einen Rest der nachfolgenden Formeln Q-1 Q-2 steht, 25 R8 für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, (C2-C6)-Alkinyl, (C2-C6)-Alkenyl, C(O)R13, C(O)OR13, (C1-C6)-Alkoxy-(C1-C6)-alkyl steht, R9 für Wasserstoff oder (C1-C6)-Alkyl steht, 30 R10 für Wasserstoff, Halogen, Cyano, NO2, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Halocycloalkyl-(C1-C6)- alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1- C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, R11R12N-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, BCS241005-Ausland STR 20 Cyano-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- carbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)- alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- C6)-alkyl, R14(O)S-(C1-C6)-alkyl, R14O2S-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, 5 Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, Tris- [(C1-C6)-Alkyl]silyl, Bis-hydroxyboryl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkoxy]boryl-(C1-C6)-alkyl, Tetramethyl-1,3,2-Dioxaborolan-2-yl, Tetramethyl-1,3,2-Dioxaborolan-2-yl-(C1-C6)-alkyl, Nitro-(C1-C6)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1-C6)-alkyl, R11R12N(O)C- (C1-C6)-alkyl, Bis-(C1-C6)-alkoxy-(C1-C6)-alkyl steht und wobei Heterocyclyl n Oxogruppen 10 trägt, oder R8 und R10 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, 15 R11 und R12 gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4- C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-20 C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C6)- Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-amino- carbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-25 alkoxycarbonyl, Heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)- Alkinyloxycarbonyl, Heterocyclyl-(C1-C6)-alkyl stehen und wobei Heterocyclyl n Oxogruppen trägt, oder R11 und R12 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder 30 teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R13 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, 35 (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)- BCS241005-Ausland STR 21 alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl- aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)- 5 alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C6)-alkyl-amino-(C2- C6)-alkyl, R14S-(C1C6)-alkyl, R14(O)S-(C1C6)-alkyl, R14O2S-(C1-C6)-alkyl, Hydroxycarbonyl- (C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1- C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, 10 Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1- 15 C8)-Alkylsulfonyl, R14 für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)- Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-20 (C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Amino, Bis-[(C1-C6)- alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1- C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1-C6)-alkyl]amino; N- Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl steht, wobei die zwölf letztgenannten 25 Reste nur an Sulfonylgruppen gebunden sind und wobei Heterocyclyl n Oxogruppen trägt, und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1-C8)-Alkylsulfonyl, 30 R15 und R16 unabhängig voneinander für (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, Aryl, Heteroaryl, Heterocyclyl stehen und wobei Heterocyclyl n Oxogruppen trägt, oder R15 und R16 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten monocyclischen 3- bis 7-gliedrigen Carbocyclus bilden, 35 R17, R18, R19 und R20 unabhängig voneinander für Wasserstoff, Halogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy, (C1-C8)-Haloalkoxy, (C3-C6)-Cycloalkyl, (C1-C6)-Haloalkyl stehen BCS241005-Ausland STR 22 und n für 0, 1 oder 2 steht. 5 Im Speziellen bevorzugter Erfindungsgegenstand sind Verbindungen der allgemeinen Formel (I), worin M für die Gruppen M-1 M-2 M-3 10 steht, wobei die gestrichelte Linie die Verknüpfungsstelle zum restlichen Teil der Formel (I) kennzeichnet, R1 für Phenyl, 2-Methylphenyl, 3-Methylphenyl, 4-Methylphenyl, 2-Trifluormethylphenyl, 3-15 Trifluormethylphenyl, 4-Trifluormethylphenyl, 2-Trifluormethoxyphenyl, 3- Trifluormethoxyphenyl, 4-Trifluormethoxyphenyl, 2-Chlorphenyl, 3-Chlorphenyl, 4- Chlorphenyl, 3-Fluorphenyl, 4-Fluorphenyl, 2-Fluorphenyl, 2-Bromphenyl, 2-Iodphenyl, 3- Bromphenyl, 3-Iodphenyl, 4-Bromphenyl, 4-Iodphenyl, 2-Difluormethylphenyl, 2- Cyanophenyl, 3-Difluormethylphenyl, 3-Cyanophenyl, 4-Difluormethylphenyl, 4-Cyanophenyl, 20 2-Methoxyphenyl, 3-Methoxyphenyl, 4-Methoxyphenyl, 3,4-Difluorphenyl, 2,4-Difluorphenyl, 2,3-Difluorphenyl, 3,5-Difluorphenyl, 2,5-Difluorphenyl, 2,6-Difluorphenyl, 3,4-Dichlorphenyl, 2,4-Dichlorphenyl, 2,3-Dichlorphenyl, 3,5-Dichlorphenyl, 2,5-Dichlorphenyl, 2,6- Dichlorphenyl, 3,4-Dibromphenyl, 2,4-Dibromphenyl, 2,3-Dibromphenyl, 3,5-Dibromphenyl, 2,5-Dibromphenyl, 3,5-Diiodphenyl, 2,4-Diiodphenyl, 2,5-Diiodphenyl, 3,4-Diiodphenyl, 3-25 Fluor-4-chlorphenyl, 2-Fluor-4-chlorphenyl, 2-Fluor-3-chlorphenyl, 2-Fluor-5-chlorphenyl, 3- Fluor-5-chlorphenyl, 2-Fluor-6-chlorphenyl, 3-Fluor-5-bromphenyl, 3-Fluor-5-iodphenyl, 3- Fluor-4-bromphenyl, 3-Fluor-4-iodphenyl, 2-Fluor-4-trifluormethylphenyl, 2-Fluor-4- methylphenyl, 2-Fluor-4-trifluormethoxyphenyl, 2-Fluor-4-trifluormethylsulfanylphenyl, 2- Fluor-4-cyanophenyl, 2-Fluor-4-methoxyphenyl, 2-Fluor-4-methoxycarbonylphenyl, 2-Fluor-4-30 hydroxycarbonylphenyl, 2-Fluor-6-trifluormethylphenyl, 2-Fluor-6-methylphenyl, 2-Fluor-6- trifluormethoxyphenyl, 2-Fluor-6-trifluormethylsulfanylphenyl, 2-Fluor-6-cyanophenyl, 2- Fluor-6-methoxyphenyl, 2-Fluor-6-methoxycarbonylphenyl, 2-Fluor-6-hydroxycarbonylphenyl, BCS241005-Ausland STR 23 3-Fluor-5-methoxycarbonylphenyl, 3-Fluor-5-hydroxycarbonylphenyl, 3-Fluor-5-cyanophenyl, 3-Fluor-5-methoxyphenyl, 3-Chlor-5-methoxyphenyl, 3-Brom-5-methoxyphenyl, 3-Iod-5- methoxyphenyl, 3-Chlor-4-fluorphenyl, 3-Brom-4-fluorphenyl, 3-Iod-4-fluorphenyl, 3-Brom-4- chlorphenyl, 3-Iod-4-chlorphenyl, 3-Iod-4-bromphenyl, 3-Iod-5-bromphenyl, 3-Brom-4- 5 iodphenyl, 4-Brom-3-chlorphenyl, 3-Chlor-4-iodphenyl, 3-Brom-5-chlorphenyl, 3-Chlor-5- iodphenyl, 3-Chlor-5-cyanophenyl, 3-Brom-5-cyanophenyl, 3-Iod-5-cyanophenyl, 2-Chlor-4- fluorphenyl, 2-Chlor-3-fluorphenyl, 2-Chlor-5-fluorphenyl, 3-Chlor-5-cyclopropylphenyl, 3-(1- Chlorcycloprop-1-yl)-5-chlorphenyl, 3-(1-Fluorcycloprop-1-yl)-5-chlorphenyl, 3-(1- Cyanocycloprop-1-yl)-5-chlorphenyl, 3-Cyclopropyl-5-fluorphenyl, 3-(1-Chlorcycloprop-1-yl)-10 5-fluorphenyl, 3-(1-Fluorcycloprop-1-yl)-5-fluorphenyl, 3-(1-Cyanocycloprop-1-yl)-5- fluorphenyl, 3-Cyclopropyl-5-bromphenyl, 3-Cyclopropyl-5-iodphenyl, 3-(1-Chlorcycloprop-1- yl)-5-bromphenyl, 3-(1-Fluorcycloprop-1-yl)-5-bromphenyl, 3-(1-Cyanocycloprop-1-yl)-5- bromphenyl, 3-(1-Cyanocycloprop-1-yl)phenyl, 4-(1-Cyanocycloprop-1-yl)phenyl, 3-(1- Fluorcycloprop-1-yl)-5-iodphenyl, 3-(1-Fluorcycloprop-1-yl)-5-trifluormethylphenyl, 3-(1-15 Fluorcycloprop-1-yl)-5-trifluormethoxyphenyl, 3,4-Dimethylphenyl, 2,4-Dimethylphenyl, 2,3- Dimethylphenyl, 2,5-Dimethylphenyl, 2,6-Dimethylphenyl, 3-Fluor-4-methylphenyl, 3-Fluor-5- methoxyphenyl, 3-Fluor-4-methoxyphenyl, 3-Fluor-5-methylphenyl, 3,5-Dimethylphenyl, 3,5- bis(Trifluormethyl)phenyl, 2,5-bis(Trifluormethyl)phenyl, 2,4-bis(Trifluormethyl)phenyl, 2,6- bis(Trifluormethyl)phenyl, 2,3-bis(Trifluormethyl)phenyl, 3,5-bis(Difluormethyl)phenyl, 3,4-20 bis(Trifluormethyl)phenyl, 3,4-bis(Difluormethyl)phenyl, 2-Trifluormethyl-4-fluorphenyl, 3- Fluor-5-trifluormethylphenyl, 3-Chlor-5-trifluormethylphenyl, 3-Brom-5-trifluormethylphenyl, 3-Iod-5-trifluormethylphenyl, 3-Trifluormethyl-4-iodphenyl, 3-Trifluormethyl-4-bromphenyl, 3- Trifluormethyl-4-trifluormethoxyphenyl, 3-Trifluormethyl-4-difluormethoxyphenyl, 3- Trifluormethyl-4-Cyanophenyl, 3-Trifluormethyl-4-methylphenyl, 3-Trifluormethyl-4-25 fluorphenyl, 3-Brom-4-trifluormethylphenyl, 3-Iod-4-Trifluormethylphenyl, 3-Methoxy-5- trifluormethylphenyl, 3-Methyl-5-trifluormethylphenyl, 3-Chlor-5-methylphenyl, 3-Brom-5- methylphenyl, 3-Iod-5-methylphenyl, 3-Difluormethoxy-5-trifluormethylphenyl, 3- Difluormethoxy-4-trifluormethylphenyl, 3-Difluormethoxy-5-trifluormethoxyphenyl, 3- Difluormethoxy-4-trifluormethoxyphenyl, 3-Difluormethoxyphenyl, 3-Chlor-5-30 difluormethoxyphenyl, 3-Chlor-4-difluormethoxyphenyl, 3-Difluormethoxy-4-chlorphenyl, 3- Brom-5-difluormethoxyphenyl, 3-Brom-4-difluormethoxyphenyl, 3-Difluormethoxy-4- bromphenyl, 3-Fluor-5-difluormethoxyphenyl, 3-Fluor-4-difluormethoxyphenyl, 3- Difluormethoxy-4-fluorphenyl, 3,5-bis(Difluormethoxy)phenyl, 3-Trifluormethoxy-5- trifluormethylphenyl, 4-Chlor-3-trifluormethoxyphenyl, 3-Cyano-5-trifluormethylphenyl, 3-35 Chlor-5-prop-2-ylphenyl, 3-Chlor-5-ethylphenyl, 3-Prop-2-yl-5-trifluormethylphenyl, 3-Ethyl-5- trifluormethylphenyl, 3-Cyclopropyl-5-trifluormethylphenyl, 3-(1-Chlorycloprop-1-yl)-5- trifluormethylphenyl, 3-(1-Fluorycloprop-1-yl)-5-trifluormethylphenyl, 3-(1-Cyanoycloprop-1- BCS241005-Ausland STR 24 yl)-5-trifluormethylphenyl, 2-Chlor-5-trifluormethylphenyl, 2-Chlor-4-trifluormethylphenyl, 3- Chlor-4-trifluormethylphenyl, 2-Chlor-6-trifluormethylphenyl, 2-Trifluormethyl-4-chlorphenyl, 3-Trifluormethyl-4-chlorphenyl, 2,3,4-Trifluorphenyl, 2,3,5-Trifluorphenyl, 3,4,5- Trifluorphenyl, 2,4,5-Trifluorphenyl, 2,3,6-Trifluorphenyl, 2,4,6-Trifluorphenyl, 3,4,5- 5 Trichlorphenyl, 3-Brom-4,5-dichlorphenyl, 3-Fluor-4,5-dichlorphenyl, 4-Brom-3,5- dichlorphenyl, 3,4-Dichlor-5-trifluormethylphenyl, 3,4-Dichlor-5-trifluormethoxyphenyl, 2- Fluor-3-methoxy-4-fluorphenyl, 2,4,6-Trimethylphenyl, 3,4,5-Trimethylphenyl, 2-Fluor-3- methylphenyl, 2-Fluor-6-methylphenyl, 2-Chlor-4,5-difluorphenyl, 2-Chlor-4-fluor-5- nitrophenyl, 2-Fluor-4-nitrophenyl, 2,4-Difluor-3-chlorphenyl, 2-Chlor-3,6-difluorphenyl, 2,3-10 Dichlor-6-fluorphenyl, 2-Chlor-4-cyanophenyl, 2-Ethyl-4,6-dimethylphenyl, 2-Fluor-6- ethoxycarbonylphenyl, 2-Fluor-6-isopropyloxyphenyl, 2,6-Difluor-3-methylphenyl, 2,6-Dichlor- 3-methylphenyl, Pyridin-2-yl, Pyridin-3-yl, 2-Fluorpyridin-3-yl, 2-Chlorpyridin-3-yl, 2,4- Difluorpyridin-3-yl, 2,4-Dichlorpyridin-3-yl, 2,6-Difluorpyridin-3-yl, 2,6-Dichlorpyridin-3-yl, 3,4-Difluorpyridin-2-yl, 3,4-Dichlorpyridin-2-yl, 3,5-Difluorpyridin-2-yl, 3,5-Dichlorpyridin-2-15 yl, 5-Chlorpyridin-2-yl, 6-Chlorpyridin-2-yl, 5-Fluorpyridin-2-yl, 6-Fluorpyridin-2-yl, 5,6- Difluorpyridin-2-yl, 5,6-Dichlorpyridin-2-yl, 4,6-Difluorpyridin-2-yl, 4,6-Dichlorpyridin-2-yl, 2,5-Difluorpyridin-3-yl, 2,5-Dichlorpyridin-3-yl, 4-Fluorpyridin-3-yl, 4-Chlorpyridin-3-yl, 5- Chlorpyridin-3-yl, 5-Brompyridin-3-yl, 4-Trifluormethylpyridin-3-yl, 4-Fluorpyridin-2-yl, 4- Chlorpyridin-2-yl, 4-Methylpyridin-2-yl, 4-Trifluormethylpyridin-2-yl, 4-Methoxypyridin-2-yl,20 4-Trifluormethoxypyridin-2-yl, 5-Trifluormethylpyridin-3-yl, 5-Trifluormethoxypyridin-3-yl, 5- Methoxypyridin-3-yl, 6-Chlorpyridin-3-yl, 6-Brompyridin-3-yl, 6-Trifluormethylpyridin-3-yl, 2- Trifluormethylpyridin-3-yl, 3-Fluor-5-trifluormethoxyphenyl, 3-Chlor-5-trifluormethoxyphenyl, 3-Brom-5-trifluormethoxyphenyl, 3-Iod-5-trifluormethoxyphenyl, 3-Methyl-5- trifluormethoxyphenyl, 3-Cyano-5-trifluormethoxyphenyl, 3-(Prop-2-yl)-5-25 trifluormethoxyphenyl, 3-(Prop-1-yl)-5-trifluormethoxyphenyl, 3-(But-1-yl)-5- trifluormethoxyphenyl, 3-(1,1-Dimethyleth-1-yl)-5-trifluormethoxyphenyl, 3-Vinyl-5- trifluormethoxyphenyl, 3-(Prop-1-en-2-yl)-5-trifluormethoxyphenyl, 3-(Prop-1-en-1-yl)-5- trifluormethoxyphenyl, 3-(1-Methylprop-1-en-1-yl)-5-trifluormethoxyphenyl, 3-Ethyl-5- trifluormethoxyphenyl, 3-Cyclopropyl-5-trifluormethoxyphenyl, 3-Cyclobutyl-5-30 trifluormethoxyphenyl, 3-Cyclopentyl-5-trifluormethoxyphenyl, 3-Cyclopent-1-en-1-yl-5- trifluormethoxyphenyl, 3-trimethylsilyl-5-trifluormethoxyphenyl, 3-(1-Methylprop-1-yl)-5- trifluormethoxyphenyl, 3-(1-Methylprop-2-yl)-5-trifluormethoxyphenyl, 3-(1-Chlorycloprop-1- yl)-5-trifluormethoxyphenyl, 3-(1-Fluorycloprop-1-yl)-5-trifluormethoxyphenyl, 3-(1- Cyanocycloprop-1-yl)-5-trifluormethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-4-35 trifluormethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-5-trifluormethylphenyl, 3-(1- Cyanocycloprop-1-yl)-4-trifluormethylphenyl, 3,5-bis(Trifluormethoxy)phenyl, 3,4- bis(Trifluormethoxy)phenyl, 3-Methoxymethyl-5-trifluormethoxyphenyl, 3,5-Dichlorpyridin-4- BCS241005-Ausland STR 25 yl, 3,5-Difluorpyridin-4-yl, 3,5-Dibrompyridin-4-yl, 3,5-Dimethylpyridin-4-yl, 3,5- bis(trifluormethyl)pyridin-4-yl, 2,6-Dichlorpyridin-4-yl, 2,6-Difluorpyridin-4-yl, 2,6- Dibrompyridin-4-yl, 2,6-Dimethylpyridin-4-yl, 2,6-bis(trifluormethyl)pyridin-4-yl, 2- Chlorpyridin-4-yl, 2-Trifluormethylpyridin-4-yl, 3-Chlorpyridin-4-yl, 3-Trifluormethylpyridin- 5 4-yl, 3-Chlor-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3-Fluor-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3- Brom-5-(pentafluor-λ⁶-sulfanyl)phenyl, 1,3-Benzothiazol-5-yl, 1,3-Benzothiazol-6-yl, 2- Methoxy-1,3-benzothiazol-5-yl, 2-Methyl-1,3-benzothiazol-5-yl, 2-Chlor-1,3-benzothiazol-5-yl, Naphth-2-yl, Naphth-1-yl, 8-Bromnaphth-2-yl, 7-Bromnaphth-2-yl, 6-Bromnaphth-2-yl, 5- Bromnaphth-2-yl, 3-Chlor-5-methylsulfonylphenyl, 3-Chlor-4-(methylsulfonyl)phenyl, 3-Brom-10 5-methylsulfonylphenyl, 3-Brom-4-methylsulfonylphenyl, 3-Methylsulfonyl-4- trifluormethylphenyl, 3-(Methylsulfonyl)-4-chlorphenyl, 4-Brom-3-methylsulfonylphenyl, 3- Chlor-5-(ethylsulfonyl)phenyl, 3-Chlor-5-(prop-2-ylsulfonyl)phenyl, 3-Chlor-5- (cyclopropylsulfonyl)phenyl, 3-Methylsulfonyl-5-trifluormethylphenyl, 3-Methylsulfonyl-5- trifluormethoxyphenyl, 3-Methylsulfonyl-5-(1H-pyrazol-1-yl)phenyl, 3-Methylsulfonyl-5-(1H-15 1,2,4-triazol-1-yl)phenyl, 3-Ethylsulfonyl-5-trifluormethoxyphenyl, 3-Ethylsulfinyl-5- trifluormethoxyphenyl, 3-Ethylsulfanyl-5-trifluormethoxyphenyl, 3-Chlor-5- (methylsulfinyl)phenyl, 3-Chlor-5-(ethylsulfinyl)phenyl, 3-Chlor-5-(prop-2-ylsulfinyl)phenyl, 3- Chlor-5-(cyclopropylsulfinyl)phenyl, 3-(Methylsulfinyl)-5-trifluormethylphenyl, 3- (Methylsulfinyl)-5-trifluormethoxyphenyl, 3-(Methylsulfinyl)-5-(1H-pyrazol-1-yl)phenyl, 3-20 (Methylsulfinyl)-5-(1H-1,2,4-triazol-1-yl)phenyl, 3-Chlor-5-(methylsulfanyl)phenyl, 3-Chlor-5- (ethylsulfanyl)phenyl, 3-Chlor-5-(prop-2-ylsulfanyl)phenyl, 3-Chlor-5- (cyclopropylsulfanyl)phenyl, 3-(Methylsulfanyl)-5-trifluormethylphenyl, 3-(Methylsulfanyl)-5- trifluormethoxyphenyl, 3-(Methylsulfanyl)-5-(1H-pyrazol-1-yl)phenyl, 3-Methylsulfanyl-5-(1H- 1,2,4-triazol-1-yl)phenyl, 2,3-Dihydro-1,4-benzodioxin-6-yl, 1,1,4,4-Tetraoxido-2,3-dihydro-25 1,4-benzodithiin-6-yl, 1,1,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,4,4-Trioxido-2,3- dihydro-1,4-benzodithiin-6-yl, 1,4-Dioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 2,3-dihydro-1,4- benzodithiin-6-yl, 1,1,3,3-Tetraoxido-1,3-benzodithiol-5-yl, 1,1,3-trioxido-1,3-benzodithiol-5- yl, 1,3-dioxido-1,3-benzodithiol-5-yl, 1,3-benzodithiol-5-yl, 2,3-dihydro-1,4-benzoxathiin-6-yl, 2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-dioxido-2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-dioxido-30 2,3-dihydro-1,4-benzoxathiin-6-yl, 3,3-dioxido-1,3-benzoxathiol-5-yl, 3-Oxido-1,3- benzoxathiol-5-yl, 1,3-Benzoxathiol-5-yl, 3,3-dioxido-1,3-benzoxathiol-6-yl, 3-Oxido-1,3- benzoxathiol-6-yl, 1,3-Benzoxathiol-6-yl, 3,5-bis(Methylsulfonyl)phenyl, 3,4- bis(Methylsulfonyl)phenyl, 3,5-bis(Methylsulfanyl)phenyl, 3,4-bis(Methylsulfanyl)phenyl, 3-(4- Chlor-1H-pyrazol-1-yl)phenyl, 3-(4-Brom-1H-pyrazol-1-yl)phenyl, 3-(4-Iod-1H-pyrazol-1-35 yl)phenyl, 3-(4-Methyl-1H-pyrazol-1-yl)phenyl, 3-(4-Trifluormethyl-1H-pyrazol-1-yl)phenyl, 3- (1H-pyrazol-1-yl)phenyl, 3-(1H-pyrazol-1-yl)-5-chlorphenyl, 3-(1H-pyrazol-1-yl)-5- trifluormethylphenyl, 3-(1H-pyrazol-1-yl)-5-trifluormethoxyphenyl, 1,3-Benzodioxol-5-yl, 7- BCS241005-Ausland STR 26 chlor-1,3-benzodioxol-5-yl, 6-chlor-1,3-benzodioxol-5-yl, 5-Methylpyrazin-2-yl, 5- Trifluormethylpyrazin-2-yl, 5-Fluorpyrazin-2-yl, 5-Chlorpyrazin-2-yl, 5-Brompyrazin-2-yl, Pyrazin-2-yl, Pyridazin-4-yl, Pyridazin-3-yl, 2-Methylpyrimidin-5-yl, Pyrimidin-5-yl, 3-Nitro-5- methoxyphenyl, 3-Nitro-4-methoxyphenyl, 3-Chlor-5-nitrophenyl, 3-Chlor-4-nitrophenyl, 3- 5 Nitro-4-chlorophenyl, 2-Nitro-5-trifluormethoxyphenyl, 3-Nitro-5-trifluormethylphenyl, 3- Nitro-4-trifluormethoxyphenyl, 3-Trifluormethyl-4-nitrophenyl, 3-Nitro-5- trifluormethoxyphenyl, 3-Nitrophenyl, 3-Phenyl-5-trifluormethylphenyl, 3- Methoxycarbonylphenyl-5-trifluormethylphenyl, 3,5-bis-(Trifluormethansulfonyl)phenyl, 3- Fluor-5-[(trifluormethyl)sulfonyl]phenyl, 3-Chlor-5-[(trifluormethyl)sulfonyl]phenyl, 3-Brom-5-10 [(trifluormethyl)sulfonyl]phenyl, 3-[(1-Cyanocycloprop-1-yl)-1-sulfonyl]-5- trifluormethoxyphenyl, 3-(1-Carbamoylcyclopropyl)-5-Trifluormethylsulfonylphenyl, 3-(2- Cyanopropyl-2-sulfonyl)-5-trifluormethoxyphenyl, 3-(1-Cyano-1-methyleth-1-yl)-5- trifluormethylsulfonylphenyl, 3-(1-Cyanocycloprop-1-yl)-5-(trifluormethylsulfonyl)phenyl, 3- (1-Cyano-1-methyleth-1-yl)-5-trifluormethylphenyl, 3-(1-Cyano-1-methyl-ethyl)-5-15 trifluormethoxyphenyl, 3-[(Difluormethyl)sulfonyl]-5-trifluormethoxyphenyl, 3,5-bis- (difluormethylsulfonyl)phenyl, 3-(1-Methylsulfonylcyclopropyl)-5-trifluormethoxyphenyl, 3- Cyclopropylsulfamoyl-5-trifluormethoxyphenyl, 3-Methylsulfamoyl-5-trifluormethoxyphenyl, 3-Sulfamoyl-5-trifluormethoxyphenyl, 3-(1-methyl-1-methylsulfonylethyl)-5- trifluormethoxyphenyl, 3-Brom-5-[Brom(difluor)methyl]phenyl, 3-Chlor-5-20 [chlor(difluor)methyl]phenyl, 3-Chlor-5-(2-chlor-1,1,2,2-tetrafluorethoxyphenyl, 3-(1- Methylsulfonylcyclopropyl)-5-trifluormethylphenyl, 3-Chlor-5-[1- (trifluormethyl)cyclopropyl]phenyl, 3-Brom-5-[1-(trifluormethyl)cyclopropyl]phenyl, 3-Bromo- 5-(2,2-dichlorcyclopropyl)phenyl, 3-Chlor-5-(2,2-dichlorcyclopropyl)phenyl, 3-Fluor-5-(2,2- dichlorcyclopropyl)phenyl, 3-Cyclopropylsulfonyl-5-trifluormethoxyphenyl, 3- 25 Cyclobutylsulfonyl-5-trifluormethoxyphenyl, 3-[(Prop-1-yl)sulfonyl]-5-trifluormethoxyphenyl, 3-[Prop-2-ylsulfonyl]-5-trifluormethoxyphenyl, 3-[1-Methyl-1-(methylsulfonyl)ethyl]-5- trifluormethylphenyl, 3-Methylsulfonyl-5-(1,1,2,2-tetrafluorethoxy)phenyl, 3-Brom-5-(1,1,2,2- tetrafluorethoxy)phenyl, 3,5-bis-(1,1,2,2-tetrafluorethoxy)phenyl, 3-(trifluormethoxy)-5- vinylphenyl, 3-formyl-5-trifluormethoxyphenyl, 3-[(Z)-(methoxyimino)methyl]-5-30 trifluormethoxyphenyl, 3-[(E)-(methoxyimino)methyl]-5-trifluormethoxyphenyl, 3-[(Z)- (ethoxyimino)methyl]-5-trifluormethoxyphenyl, 3-[(E)-(ethoxyimino)methyl]-5- trifluormethoxyphenyl, 3-[(Z)-(hydroxyimino)methyl]-5-trifluormethoxyphenyl, 3-[(E)- (hydroxyimino)methyl]-5-trifluormethoxyphenyl, 2-(2,2-Difluorcyclopropyl)phenyl, 2-(2,2- Dibromcyclopropyl)phenyl, 2-(2-Brom-2-Methylcyclopropyl)phenyl, 2-(2-35 Methylencyclopropyl)phenyl, 2-[1,1'-Bi(cyclopropyl)-1-yl]phenyl, 2-(Spiro[2.2]pentan-1- yl)phenyl, 3-(2,2-Difluorcyclopropyl)phenyl, 3-(2-Brom-2-Methylcyclopropyl)phenyl, 3-(2- Methylencyclopropyl)phenyl, 3-[1,1'-Bi(cyclopropyl)-1-yl]phenyl, 3-(Spiro[2.2]pentan-1- BCS241005-Ausland STR 27 yl)phenyl, 3-Chlor-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Brom-5-methyl-4,5-dihydro-1,2- oxazol-5-yl, 3,5-Dimethyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Trifluormethyl-5-methyl-4,5-dihydro- 1,2-oxazol-5-yl, 3-(5-Amino-2-chlor-4-fluorphenyl)-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3- (5-Nitro-2-chlor-4-fluorphenyl)-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-[2-Chlor-5-(3,5- 5 dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorphenyl]-5-methyl-4,5-dihydro- 1,2-oxazol-5-yl, 3-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6- dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{2-Brom-4-fluor- 5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5- dihydro-1,2-oxazol-5-yl, 3-{2-Iod-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-10 dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-chlor-4-fluorphenyl}-5-methyl-4,5- dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin- 1(2H)-yl]-2-brom-4-fluorphenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-iod-4-fluorphenyl}-5-methyl-4,5-15 dihydro-1,2-oxazol-5-yl, 2-{5-[3-Amino-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin- 1(2H)-yl]-2-chlor-4-fluorphenyl}-1,3-thiazol-5-yl, 2-{5-[3-Amino-2,6-dioxo-4-(trifluormethyl)- 3,6-dihydropyrimidin-1(2H)-yl]-2-brom-4-fluorphenyl}-1,3-thiazol-5-yl, 2-{5-[3-Amino-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-iod-4-fluorphenyl}-1,3-thiazol-5-yl, 2-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-20 yl]phenyl}-1,3-thiazol-5-yl, 2-{2-Brom-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6- dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 2-{2-Iod-4-fluor-5-[3-methyl-2,6-dioxo-4- (trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 2-[2-Chlor-5-(3,5- dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorphenyl]-1,3-thiazol-5-yl, 1,3- Thiazol-5-yl, 1,3-Thiazol-4-yl, 2-Chlor-1,3-thiazol-5-yl, 2-Chlor-1,3-thiazol-4-yl, 2-Methyl-1,3- 25 thiazol-5-yl, 2-Methyl-1,3-thiazol-4-yl, 4-Methyl-1,3-thiazol-2-yl, 5-Methyl-1,3-thiazol-2-yl, Thien-2-yl, Thien-3-yl, 5-Chlorthien-2-yl, 5-Bromthien-2-yl, 4-Chlorthien-2-yl, 4-Bromthien-2- yl, 3-Chlorthien-2-yl, 3-Bromthien-2-yl, 4,5-Dichlorthien-2-yl, 4,5-Dibromthien-2-yl, 3,4- Dichlorthien-2-yl, 3,4-Dibromthien-2-yl, 4-Brom-3-methoxythien-2-yl, 4-Brom-3-methylthien- 2-yl, 5-(1-Cyanocycloprop-1-yl)thien-2-yl, 3-Trifluormethylthien-2-yl, 4-Trifluormethylthien-2-30 yl, 5-Trifluormethylthien-2-yl, 3-Trifluormethoxythien-2-yl, 4-Trifluormethoxythien-2-yl, 3- Difluormethoxythien-2-yl, 4-Difluormethoxythien-2-yl, 3-Difluormethoxy-5-methylthien-2-yl, 4-Chlorthien-3-yl, 5-Chlorthien-3-yl, 2-Chlorthien-3-yl, 4-Bromthien-3-yl, 4-Methylthien-3-yl, 2,4-Dichlorthien-3-yl, 2,5-Dichlorthien-3-yl, 1-Methyl-1H-pyrazol-5-yl, 1-Ethyl-1H-pyrazol-5- yl, 4-Chlor-1,3-Dimethyl-1H-pyrazol-5-yl, 1,3-Dimethyl-1H-pyrazol-5-yl, 4-Chlor-1H-pyrazol-35 5-yl, 1-Methyl-1H-pyrazol-4-yl, 4-Methyl-1,2,3-thiadiazol-5-yl, 3-Methyl-1,2-oxazol-5-yl, 4- Methyl-1,2-oxazol-5-yl, 5-Methyl-1,2-oxazol-3-yl, 4-Methyl-1,3-oxazol-5-yl, 4,5-Dichlor-1,2- thiazol-3-yl, 1,2-Thiazol-3-yl, 1,2-Thiazol-5-yl, 4-Chlor-1,2-thiazol-5-yl, 3-Chlor-1,2-thiazol-5- BCS241005-Ausland STR 28 yl, 3,4-Dichlor-1,2-thiazol-5-yl, 3-Chlor-4-Cyano-1,2-thiazol-5-yl, 1,2-Benzoxazol-3-yl, 1,2- Benzothiazol-3-y1, 7-Chlor-1,2-benzothiazol-3-yl, 3-Trimethylsilyl-5-trifluormethylphenyl, 3,5- bis(Trimethylsilyl)phenyl, 3-(1,1-Dimethyleth-1-yl)-5-trifluormethyl, 3-Methylsulfonyl-5- (1,1,2,2-tetrafluoroethyl)phenyl, 3-Brom-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-Chlor-5-(1,1,2,2- 5 tetrafluoroethyl)phenyl 3-Fluor-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-Brom-5- cyclopropylsulfonylphenyl, 3-Cyclopropylsulfonyl-5-trimethylsilylphenyl, 3- Cyclopropylsulfonyl-5-trifluormethylphenyl, 3-[cyclopropyl(difluoro)methyl]-5- trifluoromethoxyphenyl, 3-[Cyclopropyl(difluor)methyl]-5-trifluoromethylphenyl, 3-Brom-5- [cyclopropyl(difluor)methyl]phenyl, 3-Chlor-5-[cyclopropyl(difluor)methyl]phenyl, 3-Fluor-5-10 [cyclopropyl(difluor)methyl]phenyl, 3-[Cyclopropyl(difluor)methyl]-5-methylsulfonylphenyl, 3- [Chlor(difluor)methyl]-5-methylsulfonylphenyl, 3,5-bis[Chlor(difluor)methyl]phenyl, 3-(1,1- Difluoreth-1-yl)-5-trifluormethylphenyl, 3-(1,1-Difluoreth-1-yl)-5-trifluormethoxyphenyl, 3- (1,1-Difluoreth-1-yl)-5-chlorphenyl, 3-(1,1-Difluoreth-1-yl)-5-bromphenyl, 3- trifluormethylsulfanylphenyl, 3-trifluormethylsulfanyl-5-chlorphenyl, 3-trifluormethylsulfanyl- 15 5-fluorphenyl, 3-trifluormethylsulfanyl-5-bromphenyl, 3-trifluormethylsulfanyl-4-chlorphenyl, 3-trifluormethylsulfanyl-4-fluorphenyl, 3-trifluormethylsulfanyl-4-bromphenyl, 3-(4- Methoxycarbonylphenyl)-5-trifluormethylphenyl, 3-(Oxetan-3-yl)phenyl, 3-(3-Fluoroxetan-3- yl)phenyl, 3-(Oxetan-3-yl)-5-trifluormethoxyphenyl, 3-(3-Fluoroxetan-3-yl)-5- trifluormethylphenyl, 4-Trifluormethylsulfanylpyridin-3-yl, 5-Trifluormethylsulfanylpyridin-3-20 yl, 6-Trifluormethylsulfanylpyridin-3-yl, 3-(Methylsulfonyloxy)phenyl, 3-(Methylsulfonyloxy)- 5-chlorphenyl, 3-(Methylsulfonyloxy)-5-trifluormethylphenyl, 3-(Methylsulfonyloxy)-5- trifluormethoxyphenyl, 3-(Trifluormethylsulfonyloxy)phenyl, 3-(Trifluormethylsulfonyloxy)-5- chlorphenyl, 3-(Trifluormethylsulfonyloxy)-5-trifluormethylphenyl, 3- (Trifluormethylsulfonyloxy)-5-trifluormethoxyphenyl, 4-(Methylsulfonyloxy)phenyl, 3-25 (Methylsulfonyloxy)-4-chlorphenyl, 3-(Methylsulfonyloxy)-4-trifluormethylphenyl, 3- (Methylsulfonyloxy)-4-trifluormethoxyphenyl, 3-chlor-4-(Methylsulfonyloxy)phenyl, 3- Trifluormethyl-4-(methylsulfonyloxy)phenyl, 3-Trifluormethoxy-4-(methylsulfonyloxy)phenyl, 3-(3-Methyl-1,2,4-oxadiazol-5-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(3-methyl-1,2,4- oxadiazol-5-yl)phenyl, 4-Chlor-3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl, 3-(5-Methyl-1,3,4-30 oxadiazol-2-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl, 4- Chlor-3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl, 3-(5-Methyl-1,2,4-oxadiazol-3-yl)-5- (trifluormethoxy)phenyl, 3-Chlor-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl, 4-Chlor-3-(5- methyl-1,2,4-oxadiazol-3-yl)phenyl, 3-(2,5-Dioxoimidazolidin-4-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2,5-dioxoimidazolidin-4-yl)phenyl, 4-Chlor-3-(2,5-dioxoimidazolidin-4-yl)phenyl,35 3-(5-Oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(5-oxo-4,5- dihydro-1H-1,2,4-triazol-3-yl)phenyl, 4-Chlor-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3- yl)phenyl, 3-(5-Oxo-4,5-dihydro-1H-pyrazol-3-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(5- BCS241005-Ausland STR 29 oxo-4,5-dihydro-1H-pyrazol-3-yl)phenyl, 4-Chlor-3-(5-oxo-4,5-dihydro-1H-pyrazol-3- yl)phenyl, 3-(1,3-Thiazol-2-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(1,3-thiazol-2-yl)phenyl, 4-Chlor-3-(1,3-thiazol-2-yl)phenyl, 3-(2-Methyl-1,3-thiazol-5-yl)-5-(trifluormethoxy)phenyl, 3- Chlor-5-(2-methyl-1,3-thiazol-5-yl)phenyl, 4-Chlor-3-(2-methyl-1,3-thiazol-5-yl)phenyl, 3-(1,3- 5 Oxazol-2-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(1,3-oxazol-2-yl)phenyl, 4-Chlor-3-(1,3- oxazol-2-yl)phenyl, 3-(2-Methyl-1,3-oxazol-5-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2- methyl-1,3-oxazol-5-yl)phenyl, 4-Chlor-3-(2-methyl-1,3-oxazol-5-yl)phenyl, 3-(2-Oxoazetidin- 1-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2-oxoazetidin-1-yl)phenyl, 4-Chlor-3-(2- oxoazetidin-1-yl)phenyl, 3-(2-Oxopyrrolidin-1-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2-10 oxopyrrolidin-1-yl)phenyl, 4-Chlor-3-(2-oxopyrrolidin-1-yl)phenyl, 3-(2,4-Dioxoimidazolidin- 1-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2,4-dioxoimidazolidin-1-yl)phenyl, 4-Chlor-3-(2,4- dioxoimidazolidin-1-yl)phenyl, 3-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5- (trifluormethoxy)phenyl, 3-Chlor-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl, 4-Chlor- 3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl, 3-(6-Methyl-2,4-dioxo-3,4-15 dihydropyrimidin-1(2H)-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(6-methyl-2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)phenyl, 4-Chlor-3-(6-methyl-2,4-dioxo-3,4-dihydropyrimidin- 1(2H)-yl)phenyl, 4,5-Dichlor-2-hydroxyphenyl, 3,4-Dichlor-5-hydroxyphenyl, 3,4-Dichlor-2- hydroxyphenyl, 1,3-Benzoxathiol-6-yl, 3-Methylcarbonyl-5-nitrophenyl, 4,5-Dichlor-2- fluorphenyl, 3,4-Dichlor-2-fluorphenyl, 3,4-Dichlor-5-fluorphenyl, 2,2-Difluor-1,3-20 benzodioxol-5-yl, 3-(1-Methylcycloprop-1-yl)-5-fluorphenyl, 3-(1-Methylcycloprop-1-yl)-5- chlorphenyl, 3-(1-Methylcycloprop-1-yl)-5-bromphenyl, 3-(1-Methylcycloprop-1-yl)-5- trifluormethylphenyl, 3-(1-Methylcycloprop-1-yl)-5-trifluormethoxyphenyl, 3- (Methylaminocarbonyl)-5-trifluormethoxyphenyl, 3-(Ethylaminocarbonyl)-5- trifluormethoxyphenyl, 3-(Prop-2-ylaminocarbonyl)-5-trifluormethoxyphenyl, 3-25 (Cyclopropylaminocarbonyl)-5-trifluormethoxyphenyl, 3-Aminocarbonyl-5- trifluormethoxyphenyl, 3-(Methylaminocarbonyl)-5-trifluormethylphenyl, 3- (Ethylaminocarbonyl)-5-trifluormethylphenyl, 3-(Prop-2-ylaminocarbonyl)-5- trifluormethylphenyl, 3-(Cyclopropylaminocarbonyl)-5-trifluormethylphenyl, 3-Aminocarbonyl- 5-trifluormethylphenyl, 3-(Methylaminocarbonyl)-5-chlorphenyl, 3-(Ethylaminocarbonyl)-5-30 chlorphenyl, 3-(Prop-2-ylaminocarbonyl)-5-chlorphenyl, 3-(Cyclopropylaminocarbonyl)-5- chlorphenyl, 3-Aminocarbonyl-5-chlorphenyl, 3-Methyl-5-phenyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Methyl-4,5-dihydro-1,2-oxazol-5-yl steht, R2 für Wasserstoff steht, 35 R3 für Methyl, Ethyl, Prop-1-yl, 1-Methylethyl, But-1-yl, 1-Methylprop-1-yl, 2-Methylprop-1-yl, 1,1-Dimethylethyl, Pent-1-yl, 1-Methylbut-1-yl, 2-Methylbut-1-yl, 3-Methylbut-1-yl, 1,1- BCS241005-Ausland STR 30 Dimethylprop-1-yl, 1,2-Dimethylprop-1-yl, 2,2-Dimethylprop-1-yl, 1-Ethylprop-1-yl, Hex-1-yl, 1-Methylpent-1-yl, 2-Methylpent-1-yl, 3-Methylpent-1-yl, 4-Methylpent-1-yl, 1-Ethylbut-1-yl, 2-Ethylbut-1-yl, 1,2-Dimethylbut-1-yl, 1,3-Dimethylbut-1-yl, 2,2-Dimethylbut-1-yl, 3,3- Dimethylbut-1-yl, Cyclopropyl, Cyclobutyl, Cyclopentyl, Cyclohexyl, Methoxymethyl, 5 Ethoxymethyl, Methoxyethyl, Ethoxyethyl, Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, Vinyl, Prop-1-en-1-yl, Prop-2-en-1-yl, But-1-en-1-yl, But-2-en-1-yl, But-3-en-1-yl, Pent-1-en-1-yl, Pent-2-en-1-yl, Pent-3-en-1-yl, Pent-4-en-1-yl, 1- Methylprop-2-en-1-yl, 2-Methylprop-2-en-1-yl, 1-Methylbut-2-en-1-yl, 2-Methylbut-2-en-1-yl, 3-Methylbut-2-en-1-yl, 1-Methylbut-3-en-1-yl, 2-Methylbut-3-en-1-yl, 3-Methylbut-3-en-1-yl, 10 1,1-Dimethylprop-2-en-1-yl, oder 1,2-Dimethylprop-2-en-1-yl steht, R5, R6 für Wasserstoff stehen, R7 für Wasserstoff, Fluor, Chlor, Brom, Iod, Methyl, Ethyl, Prop-1-yl, Prop-2-yl, Cyclopropyl, 15 Cyclobutyl, Methoxy, Ethoxy, Trifluormethoxy, Difluormethoxy, Difluormethyl, Trifluormethyl steht, R17, R18 , R19 und R20 unabhängig voneinander für Wasserstoff, Fluor, Chlor, Brom, Iod, Methyl, Ethyl, Prop-1-yl, Prop-2-yl, Cyclopropyl, Cyclobutyl, Cyclopentyl, Cyclohexyl, Methoxy, Ethoxy, 20 Prop-1-yloxy, Prop-2-yloxy, Trifluormethoxy, Difluormethoxy, Difluormethyl, Trifluormethyl stehen und Q für einen Rest der nachfolgenden Formeln Q-1 bis Q-500 steht 25 BCS241005-Ausland STR 31 BCS241005-Ausland STR 32 5 BCS241005-Ausland STR 33 5 BCS241005-Ausland STR 34 5 BCS241005-Ausland STR 35 5 BCS241005-Ausland STR 36 5 BCS241005-Ausland STR 37 5 BCS241005-Ausland STR 38 5 BCS241005-Ausland STR 39 5 BCS241005-Ausland STR 40 5 BCS241005-Ausland STR 41 5 BCS241005-Ausland STR 42 5 BCS241005-Ausland STR 43 5 Im ganz Speziellen bevorzugter Erfindungsgegenstand sind Verbindungen der allgemeinen Formel (I), worin 10 M für eine der Gruppen BCS241005-Ausland STR 44 M-1 M-2 M-3 steht, wobei die gestrichelte Linie die Verknüpfungsstelle zum restlichen Teil der Formel (I) kennzeichnet, 5 R1 für 3,4-Dichlorphenyl, 3,5-Dichlorphenyl, 3,4-bis(Trifluormethyl)phenyl, 3,5- bis(Trifluormethyl)phenyl, 3-Trifluormethylphenyl, 4-Trifluormethylphenyl, 3-Chlor-5- trifluormethoxyphenyl, 2-(2,2-Dibromcyclopropyl)phenyl, 3-(1-Cyanocycloprop-1-yl)phenyl, 3- Chlor-5-trifluormethylphenyl, 4-Chlor-3-trifluormethoxyphenyl, 3-Chlor-5-iodphenyl, 3-Fluor-10 5-iodphenyl, 3-Iod-4-chlorphenyl, 3-Brom-4-chlorphenyl, 3-Fluor-5-trifluormethoxyphenyl, 3- Brom-5-trifluormethoxyphenyl, 3-(Prop-2-yl)-5-trifluormethoxyphenyl, 3-[(E)- (Methoxyimino)methyl]-5-trifluormethoxyphenyl, 3-Methyl-5-trifluormethoxyphenyl, 3-Cyano- 5-trifluormethoxyphenyl, 3-Nitrophenyl, 3-Nitro-5-trifluormethylphenyl, 3-(4- Methoxycarbonylphenyl)-5-trifluormethylphenyl, 3-Fluor-5-trifluormethylphenyl, 3-Brom-5-15 trifluormethylphenyl, 3-Trifluormethyl-4-chlorphenyl, 3-Chlor-4-trifluormethylphenyl, 3,4- Diiodphenyl, 3,5-Diiodphenyl, 3-(Methylsulfanyl)-5-(1H-pyrazol-1-yl)phenyl, 4-Chlor-3- nitrophenyl, 3-Chlor-4-nitrophenyl, 5-Trifluormethylpyridin-3-yl, 2-Trifluormethylpyridin-4-yl, 5-Fluorpyrazin-2-yl, 6-Brompyridin-3-yl, 2,6-Difluorpyridin-4-yl, 3-Iod-5-trifluormethylphenyl, 3-Methylsulfonyl-5-trifluormethylphenyl, 3,5-bis(Trifluormethoxy)phenyl, 3-Difluormethoxy-5-20 trifluormethylphenyl, 3-Chlor-5-methylsulfonylphenyl, 3-Trifluormethoxyphenyl, 5- Trifluormethoxypyridin-3-yl, 3-Chlor-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3-Fluor-5-(pentafluor- λ⁶-sulfanyl)phenyl, 3-Brom-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3,5-bis(Methylsulfonyl)phenyl, 1,3-benzodithiol-5-yl, 2,3-dihydro-1,4-benzodithiin-6-yl, 2,6-bis(Trifluormethyl)phenyl, 3,4- Dibromphenyl, 3,5-bis(Methylsulfanyl)phenyl, 3,4-bis(Methylsulfanyl)phenyl, 2,3-Dihydro-1,4-25 benzoxathiin-7-yl, 2,3-Dihydro-1,4-benzoxathiin-6-yl, 1,3-Benzoxathiol-5-yl, 1,3-Benzoxathiol- 6-yl, 3-Chlor-5-cyclopropylphenyl, 3-Chlor-5-methoxyphenyl, 3-Brom-5-methoxyphenyl, 3- (1H-pyrazol-1-yl)phenyl, 3-Brom-5-methylsulfonylphenyl, 1,3-Benzodioxol-5-yl, 3-Chlor-5- nitrophenyl, 4-Brom-3-methylsulfonylphenyl, 3-Nitro-4-methoxyphenyl, 2-Methylpyrimidin-5- yl, 3-Fluor-4-methylphenyl, 4-Methoxypyridin-2-yl, 5-Methylpyrazin-2-yl, 3,4- 30 bis(Methylsulfonyl)phenyl, 3,3-Dioxido-1,3-benzoxathiol-6-yl, 3-Oxido-1,3-benzoxathiol-6-yl, 4,4-Dioxido-2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-Dioxido-2,3-dihydro-1,4-benzoxathiin-6-yl, 3,3-Dioxido-1,3-benzoxathiol-5-yl, 1,1,3,3-Tetraoxido-1,3-benzodithiol-5-yl, 3-(4-Chlor-1H- BCS241005-Ausland STR 45 pyrazol-1-yl)phenyl, 3-(4-Brom-1H-pyrazol-1-yl)phenyl, 3-(4-Iod-1H-pyrazol-1-yl)phenyl, 6- Chlor-1,3-benzodioxol-5-yl, 3-Brom-4-methylsulfonylphenyl, 6-Chlorpyridin-3-yl, 1,1,4,4- Tetraoxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,1,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,4,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 3-Ethylsulfonyl-5-trifluormethoxyphenyl, 6- 5 Fluorpyridin-2-yl, 3,5-Dibromphenyl, 4-(1-Cyanocycloprop-1-yl)phenyl, 5-Brompyridin-3-yl, 3- Brom-4,5-dichlorphenyl, 3,4,5-Trichlorphenyl, 3-(1-Cyanocycloprop-1-yl)-5-fluorphenyl, 3-(1- Cyanocycloprop-1-yl)-5-trifluormethoxyphenyl, 1,3-Benzothiazol-6-yl, 3-Chlor-5-cyanophenyl, 3-Methylsulfanyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2-Methyl-1,3-benzothiazol-5-yl, 2-Chlor-1,3- benzothiazol-5-yl, Naphth-2-yl, 3-Methylsulfonyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2-Methoxy-10 1,3-benzothiazol-5-yl, 4-Brom-3-chlorphenyl, 6-Bromnaphth-2-yl, 5-Bromnaphth-2-yl, 1,3- Benzothiazol-5-yl, 3-Methylsulfonyl-5-(1H-pyrazol-1-yl)phenyl, 2,3-Dichlorphenyl, 2,4- Dichlorphenyl, 2,5-Dichlorphenyl, 2,4-Dibromphenyl, 3,4-Difluorphenyl, 3,5-Difluorphenyl, 3,4-Dichlor-5-trifluormethoxyphenyl, 3-Iodphenyl, 4-Iodphenyl, 3-Chlor-1,2-thiazol-5-yl, 7- Chlor-1,2-benzothiazol-3-yl, 1,2-Benzoxazol-3-yl, 3,4-Dichlor-1,2-thiazol-5-yl, 4,5-Dichlor-1,2- 15 thiazol-3-yl, 3-Chlor-4-cyano-1,2-thiazol-5-yl, 1-Methyl-1H-pyrazol-5-yl, 5-Chlorthien-3-yl, 2,5-Dichlorthien-3-yl, 4-Methyl-1,2-oxazol-5-yl, 5-Methyl-1,2-oxazol-3-yl, 4-Methyl-1,3- oxazol-5-yl, 4-Methyl-1,2,3-thiadiazol-5-yl, 4-Methyl-1,3-thiazol-2-yl, 4-Chlor-1,3-Dimethyl- 1H-pyrazol-5-yl, 1,3-Thiazol-4-yl, 2-Chlor-1,3-thiazol-4-yl, 2-Chlor-1,3-thiazol-5-yl, 1,3- Thiazol-5-yl, 3-difluormethoxy-5-methylthien-2-yl, 3-Difluormethoxythien-2-yl, 4-Bromthien-20 3-yl, 3,4-Dibromthien-2-yl, 4-Brom-3-methoxythien-2-yl, 4-Brom-3-methylthien-2-yl, 5- Bromthien-2-yl, 4,5-Dichlorthien-2-yl, 5-Chlorthien-2-yl, 5-(1-cyanocycloprop-1-yl)thien-2-yl, 4,5-Dibromthien-2-yl, 3,5-Dimethyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Trifluormethyl-5-methyl- 4,5-dihydro-1,2-oxazol-5-yl, 2,3-Dibromphenyl, 2,5-Dibromphenyl, 4-Brom-3,5-Dichlorphenyl, 2,3-Difluorphenyl, 3-Fluor-4-chlorphenyl, 3-Methylcarbonyl-5-nitrophenyl, 4,5-Dichlor-2-25 fluorphenyl, 3,4-Dichlor-2-fluorphenyl, 3,4-Dichlor-5-fluorphenyl, 2,2-Difluor-1,3- benzodioxol-5-yl, 3-(1-Methylcycloprop-1-yl)-5-trifluormethoxyphenyl, 3- (Methylaminocarbonyl)-5-trifluormethoxyphenyl, 2-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4- (trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 3-[2-Chlor-5-(3,5- dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorphenyl]-5-methyl-4,5-dihydro-30 1,2-oxazol-5-yl, 2-[2-Chlor-5-(3,5-dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4- fluorphenyl]-1,3-thiazol-5-yl, 3-Methyl-5-phenyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Methyl-4,5- dihydro-1,2-oxazol-5-yl steht, R2 für Wasserstoff steht, 35 R3 für Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Cyclopropyl, Cyclobutyl, Vinyl steht, BCS241005-Ausland STR 46 R5, R6 für Wasserstoff stehen, R7 für Wasserstoff, Fluor, Chlor, Methyl, Methoxy steht, 5 R17, R18 , R19 und R20 unabhängig voneinander für Wasserstoff, Fluor, Chlor, Brom, Methyl, Methoxy, stehen und Q für einen Rest Q-1, Q-2, Q-23, Q-24, Q-26, Q-71, Q-72, Q-89, Q-91, Q-93, Q-115, Q-152, Q- 176, Q-179, Q-286, Q-287, Q-301, Q-302, Q-371, Q-441, Q-442, Q-444, Q-471, Q-472, Q-481, 10 Q-489, Q-490, Q-491, Q-499, Q-500 steht. Die oben aufgeführten allgemeinen oder in Vorzugsbereichen aufgeführten Restedefinitionen gelten sowohl für die Endprodukte der Formel (I) als auch entsprechend für die jeweils zur Herstellung benötigten Ausgangs- oder Zwischenprodukte. Diese Restedefinitionen können untereinander, also auch zwischen den angegebenen bevorzugten Bereichen, beliebig kombiniert werden. 15 Im Hinblick auf die erfindungsgemäßen Verbindungen werden die vorstehend und weiter unten verwendeten Bezeichnungen erläutert. Diese sind dem Fachmann geläufig und haben insbesondere die im Folgenden erläuterten Bedeutungen: 20 Sofern nicht anders definiert, gilt generell für die Bezeichnung von chemischen Gruppen, dass die Anbindung an das Gerüst bzw. den Rest des Moleküls über das zuletzt genannte Strukturelement der betreffenden chemischen Gruppe erfolgt, d.h. beispielsweise im Falle von (C2-C8)-Alkenyloxy über das Sauerstoffatom, und im Falle von Heterocyclyl-(C1-C8)-alkyl oder R13O(O)C-(C1-C8)-Alkyl jeweils über das C-Atom der Alkylgruppe. In einer zusammengesetzten chemischen Gruppe wie z. B. Heterocyclyl- 25 (C1-C8)-alkyl oder R13O(O)C-(C1-C8)-Alkyl steht die Bezeichnung “Alkyl” daher auch für eine Alkylengruppe. Bei den funktionellen Gruppen C(=O)R13, C(=O)OR13, C(=O)NR11R12, NR11R12, OR13, S(O)mR14 erfolgt die Anbindung an das Gerüst bzw. den Rest des Moleküls über das zuerst genannte Strukturelement der betreffenden chemischen Gruppe. 30 Erfindungsgemäß steht "Alkylsulfonyl" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes Alkylsulfonyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen, z.B. (aber nicht beschränkt auf) (C1-C6)-Alkylsulfonyl wie Methylsulfonyl, Ethyl- sulfonyl, Propylsulfonyl, 1-Methylethylsulfonyl, Butylsulfonyl, 1-Methylpropylsulfonyl, 2-Methyl- propylsulfonyl, 1,1-Dimethylethylsulfonyl, Pentylsulfonyl, 1-Methylbutylsulfonyl, 2-Methylbutyl-35 sulfonyl, 3-Methylbutylsulfonyl, 1,1-Dimethylpropylsulfonyl, 1,2-Dimethylpropylsulfonyl, 2,2-Di- methylpropylsulfonyl, 1-Ethylpropylsulfonyl, Hexylsulfonyl, 1-Methylpentylsulfonyl, 2-Methyl- pentylsulfonyl, 3-Methylpentylsulfonyl, 4-Methylpentylsulfonyl, 1,1-Dimethylbutylsulfonyl, 1,2-Di- BCS241005-Ausland STR 47 methylbutylsulfonyl, 1,3-Dimethylbutylsulfonyl, 2,2-Dimethylbutylsulfonyl, 2,3-Dimethylbutylsulfonyl, 3,3-Dimethylbutylsulfonyl, 1-Ethylbutylsulfonyl, 2-Ethylbutylsulfonyl, 1,1,2-Trimethylpropylsulfonyl, 1,2,2-Trimethylpropylsulfonyl, 1-Ethyl-1-methylpropylsulfonyl und 1-Ethyl-2-methylpropylsulfonyl. 5 Erfindungsgemäß steht "Heteroarylsulfonyl" für gegebenenfalls substituiertes Pyridylsulfonyl, Pyrimidinylsulfonyl, Pyrazinylsulfonyl oder gegebenenfalls substituiertes polycyclisches Heteroarylsulfonyl, hier insbesondere gegebenenfalls substituiertes Chinolinylsulfonyl, beispielsweise substituiert durch Fluor, Chlor, Brom, Iod, Cyano, Nitro, Alkyl-, Haloalkyl-, Haloalkoxy-, Amino-, Alkylamino-, Alkylcarbonylamino-, Dialkylamino- oder Alkoxygruppen. 10 Erfindungsgemäß steht "Alkylthio" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes S-Alkyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen, wie (C1-C10)-, (C1-C6)- oder (C1-C4)-Alkylthio, z.B. (aber nicht beschränkt auf) (C1- C6)-Alkylthio wie Methylthio, Ethylthio, Propylthio, 1-Methylethylthio, Butylthio, 1-Methylpropylthio,15 2-Methylpropylthio, 1,1-Dimethylethylthio, Pentylthio, 1-Methylbutylthio, 2-Methylbutylthio, 3- Methylbutylthio, 1,1-Dimethylpropylthio, 1,2-Dimethylpropylthio, 2,2-Dimethylpropylthio, 1- Ethylpropylthio, Hexylthio, 1-Methylpentylthio, 2-Methylpentylthio, 3-Methylpentylthio, 4-Methyl- pentylthio, 1,1-Dimethylbutylthio, 1,2-Dimethylbutylthio, 1,3-Dimethylbutylthio, 2,2-Dimethylbutyl- thio, 2,3-Dimethylbutylthio, 3,3-Dimethylbutylthio, 1-Ethylbutylthio, 2-Ethylbutylthio, 1,1,2-Tri-20 methylpropylthio, 1,2,2-Trimethylpropylthio, 1-Ethyl-1-methylpropylthio und 1-Ethyl-2-methyl- propylthio. „Alkenylthio“ bedeutet erfindungsgemäßt ein über ein Schwefelatom gebundenen Alkenylrest, Alkinylthio bedeutet ein über ein Schwefelatom gebundenen Alkinylrest, Cycloalkylthio bedeutet ein 25 über ein Schwefelatom gebundenen Cycloalkylrest und Cycloalkenylthio bedeutet ein über ein Schwefelatom gebundenen Cycloalkenylrest. „Alkylsulfinyl (Alkyl-S(=O)-)“, soweit nicht an anderer Stelle anders definiert steht erfindungsgemäß für Alkylreste, die über -S(=O)- an das Gerüst gebunden sind, wie (C1-C10)-, (C1-C6)- oder (C1-C4)- 30 Alkylsulfinyl, z. B. (aber nicht beschränkt auf) (C1-C6)-Alkylsulfinyl wie Methylsulfinyl, Ethylsulfinyl, Propylsulfinyl, 1-Methylethylsulfinyl, Butylsulfinyl, 1-Methylpropylsulfinyl, 2-Methylpropylsulfinyl, 1,1-Dimethylethylsulfinyl, Pentylsulfinyl, 1-Methylbutylsulfinyl, 2-Methylbutylsulfinyl, 3- Methylbutylsulfinyl, 1,1-Dimethylpropylsulfinyl, 1,2-Dimethylpropylsulfinyl, 2,2-Di- methylpropylsulfinyl, 1-Ethylpropylsulfinyl, Hexylsulfinyl, 1-Methylpentylsulfinyl, 2-Methylpentyl-35 sulfinyl, 3-Methylpentylsulfinyl, 4-Methylpentylsulfinyl, 1,1-Dimethylbutylsulfinyl, 1,2-Dimethyl- butylsulfinyl, 1,3-Dimethylbutylsulfinyl, 2,2-Dimethylbutylsulfinyl, 2,3-Dimethylbutylsulfinyl, 3,3- BCS241005-Ausland STR 48 Dimethylbutylsulfinyl, 1-Ethylbutylsulfinyl, 2-Ethylbutylsulfinyl, 1,1,2-Trimethylpropylsulfinyl, 1,2,2- Trimethylpropylsulfinyl, 1-Ethyl-1-methylpropylsulfinyl und 1-Ethyl-2-methylpropylsulfinyl. Analog sind „Alkenylsulfinyl“ und „Alkinylsulfinyl“, erfindungsgemäß definiert als Alkenyl- bzw. 5 Alkinylreste, die über -S(=O)- an das Gerüst gebunden sind, wie (C2-C10)-, (C2-C6)- oder (C2-C4)- Alkenylsulfinyl bzw. (C3-C10)-, (C3-C6)- oder (C3-C4)-Alkinylsulfinyl. Analog sind „Alkenylsulfonyl“ und „Alkinylsulfonyl“ erfindungsgemäß definiert als Alkenyl- bzw. Alkinylreste, die über -S(=O)2- an das Gerüst gebunden sind, wie (C2-C10)-, (C2-C6)- oder (C2-C4)- 10 Alkenylsulfonyl bzw. (C3-C10)-, (C3-C6)- oder (C3-C4)-Alkinylsulfonyl. „Alkoxy“ bedeutet ein über ein Sauerstoffatom gebundenen Alkylrest, z. B. (aber nicht beschränkt auf) (C1-C6)-Alkoxy wie Methoxy, Ethoxy, Propoxy, 1-Methylethoxy, Butoxy, 1-Methylpropoxy, 2- Methylpropoxy, 1,1-Dimethylethoxy, Pentoxy, 1-Methylbutoxy, 2-Methylbutoxy, 3-Methylbutoxy, 1,1-15 Dimethylpropoxy, 1,2-Dimethylpropoxy, 2,2-Dimethylpropoxy, 1-Ethylpropoxy, Hexoxy, 1- Methylpentoxy, 2-Methylpentoxy, 3-Methylpentoxy, 4-Methylpentoxy, 1,1-Dimethylbutoxy, 1,2-Di- methylbutoxy, 1,3-Dimethylbutoxy, 2,2-Dimethylbutoxy, 2,3-Dimethylbutoxy, 3,3-Dimethylbutoxy, 1- Ethylbutoxy, 2-Ethylbutoxy, 1,1,2-Trimethylpropoxy, 1,2,2-Trimethylpropoxy, 1-Ethyl-1-methyl- propoxy und 1-Ethyl-2-methylpropoxy. Alkenyloxy bedeutet ein über ein Sauerstoffatom gebundenen 20 Alkenylrest, Alkinyloxy bedeutet ein über ein Sauerstoffatom gebundenen Alkinylrest wie (C2-C10)-, (C2-C6)- oder (C2-C4)-Alkenoxy bzw. (C3-C10)-, (C3-C6)- oder (C3-C4)-Alkinoxy. „Cycloalkyloxy“ bedeutet ein über ein Sauerstoffatom gebundenen Cycloalkylrest und Cycloalkenyloxy bedeutet ein über ein Sauerstoffatom gebundenen Cycloalkenylrest. 25 „Alkylcarbonyl“ (Alkyl-C(=O)-), soweit nicht an anderer Stelle anders definiert, steht erfindungsgemäß für Alkylreste, die über -C(=O)- an das Gerüst gebunden sind, wie (C1-C10)-, (C1-C6)- oder (C1-C4)- Alkylcarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkylrest in der Alkylcarbonylgruppe. 30 Analog stehen „Alkenylcarbonyl“ und „Alkinylcarbonyl“, soweit nicht an anderer Stelle anders definiert, erfindungsgemäß für Alkenyl- bzw. Alkinylreste, die über -C(=O)- an das Gerüst gebunden sind, wie (C2-C10)-, (C2-C6)- oder (C2-C4)-Alkenylcarbonyl bzw. (C2-C10)-, (C2-C6)- oder (C2-C4)- Alkinylcarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkenyl- bzw. Alkinylrest in der 35 Alkenyl- bzw. Alkinylcarbonylgruppe. BCS241005-Ausland STR 49 „Alkoxycarbonyl (Alkyl-O-C(=O)-)“, soweit nicht an anderer Stelle anders definiert: Alkylreste, die über -O-C(=O)- an das Gerüst gebunden sind, wie (C1-C10)-, (C1-C6)- oder (C1-C4)-Alkoxycarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkylrest in der Alkoxycarbonylgruppe. Analog stehen „Alkenyloxycarbonyl“ und „Alkinyloxycarbonyl“, soweit nicht an anderer Stelle anders definiert, 5 erfindungsgemäß für Alkenyl- bzw. Alkinylreste, die über -O-C(=O)- an das Gerüst gebunden sind, wie (C2-C10)-, (C2-C6)- oder (C2-C4)-Alkenyloxycarbonyl bzw. (C3-C10)-, (C3-C6)- oder (C3-C4)- Alkinyloxycarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkenyl- bzw. Alkinylrest in der Alken- bzw. Alkinyloxycarbonylgruppe. 10 Der Begriff „Alkylcarbonyloxy“ (Alkyl-C(=O)-O-) steht erfindungsgemäß, soweit nicht an anderer Stelle anders definiert, für Alkylreste, die über eine Carbonyloxygruppe (-C(=O)-O-) mit dem Sauerstoff an das Gerüst gebunden sind, wie (C1-C10)-, (C1-C6)- oder (C1-C4)-Alkylcarbonyloxy. Die Anzahl der C- Atome bezieht sich dabei auf den Alkylrest in der Alkylcarbonyloxygruppe. 15 Analog sind „Alkenylcarbonyloxy“ und „Alkinylcarbonyloxy“ erfindungsgemäß definiert als Alkenyl- bzw. Alkinylreste, die über (-C(=O)-O-) mit dem Sauerstoff an das Gerüst gebunden sind, wie (C2-C10)-, (C2-C6)- oder (C2-C4)-Alkenylcarbonyloxy bzw. (C2-C10)-, (C2-C6)- oder (C2-C4)-Alkinylcarbonyloxy. Die Anzahl der C-Atome bezieht sich dabei auf den Alkenyl- bzw. Alkinylrest in der Alkenyl- bzw. Alkinylcarbonyloxygruppe. 20 In Kurzformen wie z.B. C(O)R13, C(O)OR13, OC(O)NR11R12, oder C(O)NR11R12 steht die in Klammern aufgeführte Kurzform O für ein über eine Doppelbindung an das benachbarte Kohlenstoffatom gebundenes Sauerstoffatom. 25 In Kurzformen wie z.B. OC(S)OR13, OC(S)SR14, OC(S)NR11R12, steht die in Klammern aufgeführte Kurzform S für ein über eine Doppelbindung an das benachbarte Kohlenstoffatom gebundenes Schwefelatom. Der Begriff „Aryl“ bedeutet ein gegebenenfalls substituiertes mono-, bi- oder polycyclisches 30 aromatisches System mit vorzugsweise 6 bis 14, insbesondere 6 bis 10 Ring-C-Atomen, beispielsweise Phenyl, Naphthyl, Anthryl, Phenanthrenyl, und ähnliches, vorzugsweise Phenyl oder Naphtyl, insbesondere vorzugsweise Phenyl. Vom Begriff „gegebenenfalls substituiertes Aryl“ sind auch mehrcyclische Systeme, wie 35 Tetrahydronaphtyl, Indenyl, Indanyl, Fluorenyl, Biphenylyl, umfasst, wobei die Bindungsstelle am aromatischen System ist. Von der Systematik her ist „Aryl“ in der Regel auch von dem Begriff „gegebenenfalls substituiertes Phenyl“ umfasst. Bevorzugte Aryl-Substituenten sind hier zum Beispiel BCS241005-Ausland STR 50 Wasserstoff, Halogen, Alkyl, Cycloalkyl, Cycloalkylalkyl, Cycloalkenyl, Halocycloalkyl, Alkenyl, Alkinyl, Aryl, Arylalkyl, Arylalkenyl, Heteroaryl, Heteroarylalkyl, Heterocyclyl, Heterocyclylalkyl, Alkoxyalkyl, Alkylthio, Haloalkylthio, Haloalkyl, Alkoxy, Haloalkoxy, Cycloalkoxy, Cycloalkylalkoxy, Aryloxy, Heteroraryloxy, Alkoxyalkoxy, Alkinylalkoxy, Alkenyloxy, Bis-alkylaminoalkoxy, Tris- 5 [alkyl]silyl, Bis-[alkyl]arylsilyl, Bis-[alkyl]alkylsilyl, Tris-[alkyl]silylalkinyl, Arylalkinyl, Heteroarylalkinyl, Alkylalkinyl, Cycloalkylalkinyl, Haloalkylalkinyl, Heterocyclyl-N-alkoxy, Nitro, Cyano, Amino, Alkylamino, Bis-alkylamino, Alkylcarbonylamino, Cycloalkylcarbonylamino, Arylcarbonylamino, Alkoxycarbonylamino, Alkoxycarbonylalkylamino, Arylalkoxycarbonylalkylamino, Hydroxycarbonyl, Alkoxycarbonyl, Aminocarbonyl, 10 Alkylaminocarbonyl, Cycloalkylaminocarbonyl, Bis-Alkylaminocarbonyl, Heteroarylalkoxy, Arylalkoxy Wenn nicht anders in einem bestimmten Kontext hier definiert, enthält ein „heterocyclischer Rest“ („Heterocyclyl“) mindestens einen heterocyclischen Ring (=carbocyclischer Ring, in dem mindestens 15 ein C-Atom durch ein Heteroatom ersetzt ist, vorzugsweise durch ein Heteroatom aus der Gruppe N, O, S, P) der gesättigt, ungesättigt, teilgesättigt oder heteroaromatisch ist und dabei unsubstituiert oder substituiert sein kann, wobei die Bindungsstelle an einem Ringatom lokalisiert ist. Ist der Heterocyclylrest oder der heterocyclische Ring gegebenenfalls substituiert, kann er mit anderen carbocyclischen oder heterocyclischen Ringen annelliert sein. Im Falle von gegebenenfalls 20 substituiertem Heterocyclyl werden auch mehrcyclische Systeme umfasst, wie beispielsweise 8-Aza- bicyclo[3.2.1]octanyl, 8-Aza-bicyclo[2.2.2]octanyl oder 1-Aza-bicyclo[2.2.1]heptyl. Im Falle von gegebenenfalls substituiertem Heterocyclyl werden auch spirocyclische Systeme umfasst, wie beispielsweise 1-Oxa-5-aza-spiro[2.3]hexyl. Wenn nicht anders definiert, enthält der heterocyclische Ring vorzugsweise 3 bis 9 Ringatome, insbesondere 3 bis 6 Ringatome, und ein oder mehrere, 25 vorzugsweise 1 bis 4, insbesondere 1, 2 oder 3 Heteroatome im heterocyclischen Ring, vorzugsweise aus der Gruppe N, O, und S, wobei jedoch nicht zwei Sauerstoffatome direkt benachbart sein sollen, wie beispielsweise mit einem Heteroatom aus der Gruppe N, O und S 1- oder 2- oder 3-Pyrrolidinyl, 3,4- Dihydro-2H-pyrrol-2- oder 3-yl, 2,3-Dihydro-1H-pyrrol-1- oder 2- oder 3- oder 4- oder 5-yl; 2,5- Dihydro-1H-pyrrol-1- oder 2- oder 3-yl, 1- oder 2- oder 3- oder 4-Piperidinyl; 2,3,4,5- 30 Tetrahydropyridin-2- oder 3- oder 4- oder 5-yl oder 6-yl; 1,2,3,6-Tetrahydropyridin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,2,3,4-Tetrahydropyridin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,4- Dihydropyridin-1- oder 2- oder 3- oder 4-yl; 2,3-Dihydropyridin-2- oder 3- oder 4- oder 5- oder 6-yl; 2,5-Dihydropyridin-2- oder 3- oder 4- oder 5- oder 6-yl, 1- oder 2- oder 3- oder 4-Azepanyl; 2,3,4,5- Tetrahydro-1H-azepin-1- oder 2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydro-1H- 35 azepin-1- oder 2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydro-1H-azepin-1- oder 2- oder 3- oder 4-yl; 3,4,5,6-Tetrahydro-2H-azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5- Dihydro-1H-azepin-1- oder 2- oder 3- oder 4-yl; 2,5-Dihydro-1H-azepin-1- oder -2- oder 3- oder 4- oder BCS241005-Ausland STR 51 5- oder 6- oder 7-yl; 2,7-Dihydro-1H-azepin-1- oder -2- oder 3- oder 4-yl; 2,3-Dihydro-1H-azepin-1- oder -2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 3,4-Dihydro-2H-azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 3,6-Dihydro-2H-azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 5,6-Dihydro-2H- azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-3H-azepin-2- oder 3- oder 4- oder 5- 5 oder 6- oder 7-yl; 1H-Azepin-1- oder -2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2H-Azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 3H-Azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4H-Azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl, 2- oder 3-Oxolanyl (= 2- oder 3-Tetrahydrofuranyl); 2,3- Dihydrofuran-2- oder 3- oder 4- oder 5-yl; 2,5-Dihydrofuran-2- oder 3-yl, 2- oder 3- oder 4-Oxanyl (= 2- oder 3- oder 4-Tetrahydropyranyl); 3,4-Dihydro-2H-pyran-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6- 10 Dihydro-2H-pyran-2- oder 3-oder 4- oder 5- oder 6-yl; 2H-Pyran-2- oder 3- oder 4- oder 5- oder 6-yl; 4H-Pyran-2- oder 3- oder 4-yl, 2- oder 3- oder 4-Oxepanyl; 2,3,4,5-Tetrahydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7- Tetrahydrooxepin-2- oder 3- oder 4-yl; 2,3-Dihydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydrooxepin-2- oder 3- oder 4-yl; 2,5-Dihydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl;15 Oxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2- oder 3-Tetrahydrothiophenyl; 2,3- Dihydrothiophen-2- oder 3- oder 4- oder 5-yl; 2,5-Dihydrothiophen-2- oder 3-yl; Tetrahydro-2H- thiopyran-2- oder 3- oder 4-yl; 3,4-Dihydro-2H-thiopyran-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6- Dihydro-2H-thiopyran-2- oder 3- oder 4- oder 5- oder 6-yl; 2H-Thiopyran-2- oder 3- oder 4- oder 5- oder 6-yl; 4H-Thiopyran-2- oder 3- oder 4-yl. Bevorzugte 3-Ring und 4-Ring-Heterocyclen sind20 beispielsweise 1- oder 2-Aziridinyl, Oxiranyl, Thiiranyl, 1- oder 2- oder 3-Azetidinyl, 2- oder 3- Oxetanyl, 2- oder 3-Thietanyl, 1,3-Dioxetan-2-yl. Weitere Beispiele für “Heterocyclyl“ sind ein partiell oder vollständig hydrierter heterocyclischer Rest mit zwei Heteroatomen aus der Gruppe N, O und S, wie beispielsweise 1- oder 2- oder 3- oder 4-Pyrazolidinyl; 4,5-Dihydro-3H-pyrazol- 3- oder 4- oder 5- yl; 4,5-Dihydro-1H-pyrazol-1- oder 3- oder 4- oder 5-yl; 2,3-Dihydro-1H-pyrazol-1- oder 2- oder 3- 25 oder 4- oder 5-yl; 1- oder 2- oder 3- oder 4- Imidazolidinyl; 2,3-Dihydro-1H-imidazol-1- oder 2- oder 3- oder 4-yl; 2,5-Dihydro-1H-imidazol-1- oder 2- oder 4- oder 5-yl; 4,5-Dihydro-1H-imidazol-1- oder 2- oder 4- oder 5-yl; Hexahydropyridazin-1- oder 2- oder 3- oder 4-yl; 1,2,3,4-Tetrahydropyridazin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,2,3,6-Tetrahydropyridazin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,4,5,6-Tetrahydropyridazin-1- oder 3- oder 4- oder 5- oder 6-yl; 3,4,5,6-Tetrahydropyridazin-3- 30 oder 4- oder 5-yl; 4,5-Dihydropyridazin-3- oder 4-yl; 3,4-Dihydropyridazin-3- oder 4- oder 5- oder 6-yl; 3,6-Dihydropyridazin-3- oder 4-yl; 1,6-Dihydropyriazin-1- oder 3- oder 4- oder 5- oder 6-yl; Hexahydropyrimidin-1- oder 2- oder 3- oder 4-yl; 1,4,5,6-Tetrahydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 1,2,5,6-Tetrahydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 1,2,3,4- Tetrahydropyrimidin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,6-Dihydropyrimidin-1- oder 2- oder35 4- oder 5- oder 6-yl; 1,2-Dihydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 2,5-Dihydropyrimidin- 2- oder 4- oder 5-yl; 4,5-Dihydropyrimidin- 4- oder 5- oder 6-yl; 1,4-Dihydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 1- oder 2- oder 3-Piperazinyl; 1,2,3,6-Tetrahydropyrazin-1- oder 2- oder 3- oder 5- BCS241005-Ausland STR 52 oder 6-yl; 1,2,3,4-Tetrahydropyrazin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,2-Dihydropyrazin-1- oder 2- oder 3- oder 5- oder 6-yl; 1,4-Dihydropyrazin-1- oder 2- oder 3-yl; 2,3-Dihydropyrazin-2- oder 3- oder 5- oder 6-yl; 2,5-Dihydropyrazin-2- oder 3-yl; 1,3-Dioxolan-2- oder 4- oder 5-yl; 1,3-Dioxol-2- oder 4-yl; 1,3-Dioxan-2- oder 4- oder 5-yl; 4H-1,3-Dioxin-2- oder 4- oder 5- oder 6-yl; 1,4-Dioxan-2- 5 oder 3- oder 5- oder 6-yl; 2,3-Dihydro-1,4-dioxin-2- oder 3- oder 5- oder 6-yl; 1,4-Dioxin-2- oder 3-yl; 1,2-Dithiolan-3- oder 4-yl; 3H-1,2-Dithiol-3- oder 4- oder 5-yl; 1,3-Dithiolan-2- oder 4-yl; 1,3-Dithiol- 2- oder 4-yl; 1,2-Dithian-3- oder 4-yl; 3,4-Dihydro-1,2-dithiin-3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro- 1,2-dithiin-3- oder 4-yl; 1,2-Dithiin-3- oder 4-yl; 1,3-Dithian-2- oder 4- oder 5-yl; 4H-1,3-Dithiin-2- oder 4- oder 5- oder 6-yl; Isoxazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydroisoxazol-2- oder 3- oder 10 4- oder 5-yl; 2,5-Dihydroisoxazol-2- oder 3- oder 4- oder 5-yl; 4,5-Dihydroisoxazol-3- oder 4- oder 5-yl; 1,3-Oxazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydro-1,3-oxazol-2- oder 3- oder 4- oder 5-yl; 2,5- Dihydro-1,3-oxazol-2- oder 4- oder 5-yl; 4,5-Dihydro-1,3-oxazol-2- oder 4- oder 5-yl; 1,2-Oxazinan-2- oder 3- oder 4- oder 5- oder 6-yl; 3,4-Dihydro-2H-1,2-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6- Dihydro-2H-1,2-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-2H-1,2-oxazin-2- oder 3- oder 15 4- oder 5- oder 6-yl; 5,6-Dihydro-4H-1,2-oxazin-3- oder 4- oder 5- oder 6-yl; 2H-1,2-Oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 6H-1,2-Oxazin-3- oder 4- oder 5- oder 6-yl; 4H-1,2-Oxazin-3- oder 4- oder 5- oder 6-yl; 1,3-Oxazinan-2- oder 3- oder 4- oder 5- oder 6-yl; 3,4-Dihydro-2H-1,3-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-1,3-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-2H- 1,3-oxazin-2- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-4H-1,3-oxazin-2- oder 4- oder 5- oder 6-yl; 2H- 20 1,3-Oxazin-2- oder 4- oder 5- oder 6-yl; 6H-1,3-Oxazin-2- oder 4- oder 5- oder 6-yl; 4H-1,3-Oxazin-2- oder 4- oder 5- oder 6-yl; Morpholin-2- oder 3- oder 4-yl; 3,4-Dihydro-2H-1,4-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-1,4-oxazin-2- oder 3- oder 5- oder 6-yl; 2H-1,4-oxazin-2- oder 3- oder 5- oder 6-yl; 4H-1,4-oxazin-2- oder 3-yl; 1,2-Oxazepan-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 2,3,4,5-Tetrahydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydro-1,2- 25 oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,5,6,7-Tetrahydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 4,5,6,7-Tetrahydro-1,2-oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,5-Dihydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-1,2- 30 oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 4,7-Dihydro-1,2-oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 6,7-Dihydro-1,2-oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 1,2-Oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 1,3-Oxazepan-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,5-Tetrahydro-1,3- oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydro-1,3-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydro-1,3-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-35 yl; 2,5,6,7-Tetrahydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 4,5,6,7-Tetrahydro-1,3- oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-1,3-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,5-Dihydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-1,3-oxazepin- BCS241005-Ausland STR 53 2- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 4,7- Dihydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 6,7-Dihydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 1,3-Oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 1,4-Oxazepan-2- oder 3- oder 5- oder 6- oder 7-yl; 2,3,4,5-Tetrahydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7- 5 Tetrahydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydro-1,4-oxazepin- 2- oder 3- oder 5- oder 6- oder 7-yl; 2,5,6,7-Tetrahydro-1,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7- yl; 4,5,6,7-Tetrahydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-1,4- oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 2,5-Dihydro-1,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-1,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-1,4-oxazepin-2- oder10 3- oder 4- oder 5- oder 6- oder 7-yl; 4,7-Dihydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 6,7-Dihydro-1,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 1,4-Oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; Isothiazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydroisothiazol-2- oder 3- oder 4- oder 5- yl; 2,5-Dihydroisothiazol-2- oder 3- oder 4- oder 5-yl; 4,5-Dihydroisothiazol-3- oder 4- oder 5-yl; 1,3- Thiazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydro-1,3-thiazol-2- oder 3- oder 4- oder 5-yl; 2,5- 15 Dihydro-1,3-thiazol-2- oder 4- oder 5-yl; 4,5-Dihydro-1,3-thiazol-2- oder 4- oder 5-yl; 1,3-Thiazinan-2- oder 3- oder 4- oder 5- oder 6-yl; 3,4-Dihydro-2H-1,3-thiazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6- Dihydro-2H-1,3-thiazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-2H-1,3-thiazin-2- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-4H-1,3-thiazin-2- oder 4- oder 5- oder 6-yl; 2H-1,3-Thiazin-2- oder 4- oder 5- oder 6-yl; 6H-1,3-Thiazin-2- oder 4- oder 5- oder 6-yl; 4H-1,3-Thiazin-2- oder 4- oder 5- oder 6-yl. 20 Weitere Beispiele für “Heterocyclyl“ sind ein partiell oder vollständig hydrierter heterocyclischer Rest mit 3 Heteroatomen aus der Gruppe N, O und S, wie beispielsweise 1,4,2-Dioxazolidin-2- oder 3- oder 5-yl; 1,4,2-Dioxazol-3- oder 5-yl; 1,4,2-Dioxazinan-2- oder -3- oder 5- oder 6-yl; 5,6-Dihydro-1,4,2- dioxazin-3- oder 5- oder 6-yl; 1,4,2-Dioxazin-3- oder 5- oder 6-yl; 1,4,2-Dioxazepan-2- oder 3- oder 5- oder 6- oder 7-yl; 6,7-Dihydro-5H-1,4,2-Dioxazepin-3- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-7H-1,4,2- 25 Dioxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-5H-1,4,2-Dioxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 5H-1,4,2-Dioxazepin-3- oder 5- oder 6- oder 7-yl; 7H-1,4,2-Dioxazepin-3- oder 5- oder 6- oder 7-yl. Strukturbeispiele für gegebenenfalls weiter substituierte Heterocyclen sind auch im Folgenden aufgeführt: BCS241005-Ausland STR 54 BCS241005-Ausland STR 55 Die oben aufgeführten Heterocyclen sind bevorzugt beispielsweise durch Wasserstoff, Halogen, Alkyl, Haloalkyl, Hydroxy, Alkoxy, Cycloalkoxy, Aryloxy, Alkoxyalkyl, Alkoxyalkoxy, Cycloalkyl, Halocycloalkyl, Aryl, Arylalkyl, Heteroaryl, Heterocyclyl, Alkenyl, Alkylcarbonyl, Cycloalkylcarbonyl, 5 Arylcarbonyl, Heteroarylcarbonyl, Alkoxycarbonyl, Hydroxycarbonyl, Cycloalkoxycarbonyl, Cycloalkylalkoxycarbonyl, Alkoxycarbonylalkyl, Arylalkoxycarbonyl, Arylalkoxycarbonylalkyl, Alkinyl, Alkinylalkyl, Alkylalkinyl, Tris-alkylsilylalkinyl, Nitro, Amino, Cyano, Haloalkoxy, BCS241005-Ausland STR 56 Haloalkylthio, Alkylthio, Hydrothio, Hydroxyalkyl, Oxo, Heteroarylalkoxy, Arylalkoxy, Heterocyclylalkoxy, Heterocyclylalkylthio, Heterocyclyloxy, Heterocyclylthio, Heteroaryloxy, Bis- alkylamino, Alkylamino, Cycloalkylamino, Hydroxycarbonylalkylamino, Alkoxycarbonylalkylamino, Arylalkoxycarbonylalkylamino, Alkoxycarbonylalkyl(alkyl)amino, Aminocarbonyl, 5 Alkylaminocarbonyl, Bis-alkylaminocarbonyl, Cycloalkylaminocarbonyl, Hydroxycarbonylalkylaminocarbonyl, Alkoxycarbonylalkylaminocarbonyl, Arylalkoxycarbonylalkylaminocarbonyl substituiert. Wenn ein Grundkörper "durch einen oder mehrere Reste" aus einer Aufzählung von Resten (= Gruppe) 10 oder einer generisch definierten Gruppe von Resten substituiert ist, so schließt dies jeweils die gleichzeitige Substitution durch mehrere gleiche und/oder strukturell unterschiedliche Reste ein. Handelt es sich es sich um einen teilweise oder vollständig gesättigten Stickstoff-Heterocyclus, so kann dieser sowohl über Kohlenstoff als auch über den Stickstoff mit dem Rest des Moleküls verknüpft sein. 15 Als Substituenten für einen substituierten heterocyclischen Rest kommen die weiter unten genannten Substituenten in Frage, zusätzlich auch Oxo und Thioxo. Die „Oxogruppe“ als Substituent an einem Ring-C-Atom bedeutet dann beispielsweise eine Carbonylgruppe im heterocyclischen Ring. Dadurch sind vorzugsweise auch Lactone und Lactame umfasst. Die Oxogruppe kann auch an den 20 Heteroringatomen, die in verschiedenen Oxidationsstufen existieren können, z.B. bei N und S, auftreten und bilden dann beispielsweise die divalenten Gruppen N(O) , S(O) (auch kurz SO) und S(O)2 (auch kurz SO2) im heterocyclischen Ring. Im Fall von –N(O)- und –S(O)-Gruppen sind jeweils beide Enantiomere umfasst. 25 Erfindungsgemäß steht der Ausdruck „Heteroaryl“ für heteroaromatische Verbindungen, d. h. vollständig ungesättigte aromatische heterocyclische Verbindungen, vorzugsweise für 5- bis 7-gliedrige Ringe mit 1 bis 4, vorzugsweise 1 oder 2 gleichen oder verschiedenen Heteroatomen, vorzugsweise O, S oder N. Erfindungsgemäße Heteroaryle sind beispielsweise 1H-Pyrrol-1-yl; 1H-Pyrrol-2-yl; 1H-Pyrrol- 3-yl; Furan-2-yl; Furan-3-yl; Thien-2-yl; Thien-3-yl, 1H-Imidazol-1-yl; 1H-Imidazol-2-yl; 1H-Imidazol-30 4-yl; 1H-Imidazol-5-yl; 1H-Pyrazol-1-yl; 1H-Pyrazol-3-yl; 1H-Pyrazol-4-yl; 1H-Pyrazol-5-yl, 1H-1,2,3- Triazol-1-yl, 1H-1,2,3-Triazol-4-yl, 1H-1,2,3-Triazol-5-yl, 2H-1,2,3-Triazol-2-yl, 2H-1,2,3-Triazol-4-yl, 1H-1,2,4-Triazol-1-yl, 1H-1,2,4-Triazol-3-yl, 4H-1,2,4-Triazol-4-yl, 1,2,4-Oxadiazol-3-yl, 1,2,4- Oxadiazol-5-yl, 1,3,4-Oxadiazol-2-yl, 1,2,3-Oxadiazol-4-yl, 1,2,3-Oxadiazol-5-yl, 1,2,5-Oxadiazol-3-yl, Azepinyl, Pyridin-2-yl, Pyridin-3-yl, Pyridin-4-yl, Pyrazin-2-yl, Pyrazin-3-yl, Pyrimidin-2-yl, 35 Pyrimidin-4-yl, Pyrimidin-5-yl, Pyridazin-3-yl, Pyridazin-4-yl, 1,3,5-Triazin-2-yl, 1,2,4-Triazin-3-yl, 1,2,4-Triazin-5-yl, 1,2,4-Triazin-6-yl, 1,2,3-Triazin-4-yl, 1,2,3-Triazin-5-yl, 1,2,4-, 1,3,2-, 1,3,6- und 1,2,6-Oxazinyl, Isoxazol-3-yl, Isoxazol-4-yl, Isoxazol-5-yl, 1,3-Oxazol-2-yl, 1,3-Oxazol-4-yl, 1,3- BCS241005-Ausland STR 57 Oxazol-5-yl, Isothiazol-3-yl, Isothiazol-4-yl, Isothiazol-5-yl, 1,3-Thiazol-2-yl, 1,3-Thiazol-4-yl, 1,3- Thiazol-5-yl, Oxepinyl, Thiepinyl, 1,2,4-Triazolonyl und 1,2,4-Diazepinyl, 2H-1,2,3,4-Tetrazol-5-yl, 1H-1,2,3,4-Tetrazol-5-yl, 1,2,3,4-Oxatriazol-5-yl, 1,2,3,4-Thiatriazol-5-yl, 1,2,3,5-Oxatriazol-4-yl, 1,2,3,5-Thiatriazol-4-yl. Die erfindungsgemäßen Heteroarylgruppen können ferner mit einem oder 5 mehreren, gleichen oder verschiedenen Resten substituiert sein. Sind zwei benachbarte Kohlenstoffatome Bestandteil eines weiteren aromatischen Rings, so handelt es sich um annellierte heteroaromatische Systeme, wie benzokondensierte oder mehrfach annellierte Heteroaromaten. Bevorzugt sind beispielsweise Chinoline (z. B. Chinolin-2-yl, Chinolin-3-yl, Chinolin-4-yl, Chinolin-5- yl, Chinolin-6-yl, Chinolin-7-yl, Chinolin-8-yl); Isochinoline (z. B. Isochinolin-1-yl, Isochinolin-3-yl, 10 Isochinolin-4-yl, Isochinolin-5-yl, Isochinolin-6-yl, Isochinolin-7-yl, Isochinolin-8-yl); Chinoxalin; Chinazolin; Cinnolin; 1,5-Naphthyridin; 1,6-Naphthyridin; 1,7-Naphthyridin; 1,8-Naphthyridin; 2,6- Naphthyridin; 2,7-Naphthyridin; Phthalazin; Pyridopyrazine; Pyridopyrimidine; Pyridopyridazine; Pteridine; Pyrimidopyrimidine. Beispiele für Heteroaryl sind auch 5- oder 6-gliedrige benzokondensierte Ringe aus der Gruppe 1H-Indol-1-yl, 1H-Indol-2-yl, 1H-Indol-3-yl, 1H-Indol-4-yl, 1H-Indol-5-yl, 1H-15 Indol-6-yl, 1H-Indol-7-yl, 1-Benzofuran-2-yl, 1-Benzofuran-3-yl, 1-Benzofuran-4-yl, 1-Benzofuran-5- yl, 1-Benzofuran-6-yl, 1-Benzofuran-7-yl, 1-Benzothiophen-2-yl, 1-Benzothiophen-3-yl, 1- Benzothiophen-4-yl, 1-Benzothiophen-5-yl, 1-Benzothiophen-6-yl, 1-Benzothiophen-7-yl, 1H-Indazol- 1-yl, 1H-Indazol-3-yl, 1H-Indazol-4-yl, 1H-Indazol-5-yl, 1H-Indazol-6-yl, 1H-Indazol-7-yl, 2H-Indazol- 2-yl, 2H-Indazol-3-yl, 2H-Indazol-4-yl, 2H-Indazol-5-yl, 2H-Indazol-6-yl, 2H-Indazol-7-yl, 2H- 20 Isoindol-2-yl, 2H-Isoindol-1-yl, 2H-Isoindol-3-yl, 2H-Isoindol-4-yl, 2H-Isoindol-5-yl, 2H-Isoindol-6-yl; 2H-Isoindol-7-yl, 1H-Benzimidazol-1-yl, 1H-Benzimidazol-2-yl, 1H-Benzimidazol-4-yl, 1H- Benzimidazol-5-yl, 1H-Benzimidazol-6-yl, 1H-Benzimidazol-7-yl, 1,3-Benzoxazol-2-yl, 1,3- Benzoxazol-4-yl, 1,3-Benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-Benzoxazol-7-yl, 1,3-Benzthiazol-2-yl, 1,3-Benzthiazol-4-yl, 1,3-Benzthiazol-5-yl, 1,3-Benzthiazol-6-yl, 1,3-Benzthiazol-7-yl, 1,2-25 Benzisoxazol-3-yl, 1,2-Benzisoxazol-4-yl, 1,2-Benzisoxazol-5-yl, 1,2-Benzisoxazol-6-yl, 1,2- Benzisoxazol-7-yl, 1,2-Benzisothiazol-3-yl, 1,2-Benzisothiazol-4-yl, 1,2-Benzisothiazol-5-yl, 1,2- Benzisothiazol-6-yl, 1,2-Benzisothiazol-7-yl. Die Bezeichnung "Halogen" bedeutet beispielsweise Fluor, Chlor, Brom oder Iod. Wird die 30 Bezeichnung für einen Rest verwendet, dann bedeutet "Halogen" beispielsweise ein Fluor-, Chlor-, Brom- oder Iodatom. Erfindungsgemäß bedeutet „Alkyl“ einen geradkettigen oder verzweigten offenkettigen, gesättigten Kohlenwasserstoffrest, der gegebenenfalls ein- oder mehrfach substituiert ist und im letzteren Falle als 35 „substituiertes Alkyl“ bezeichnet wird. Bevorzugte Substituenten sind Halogenatome, Alkoxy-, Haloalkoxy-, Cyano-, Alkylthio, Haloalkylthio-, Amino- oder Nitrogruppen, besonders bevorzugt sind Methoxy, Methyl, Fluoralkyl, Cyano, Nitro, Fluor, Chlor, Brom oder Iod. Die Vorsilbe „Bis“ schließt BCS241005-Ausland STR 58 auch die Kombination unterschiedlicher Alkylreste ein, z. B. Methyl(Ethyl) oder Ethyl(Methyl). Alkylreste können in Abhängigkeit von der verwendeten Schreibweise unterschiedliche Bezeichnungen für die gleiche Gruppe haben, die allerdings fachlich geläufig sind. Beispielsweise sind die Bezeichnungen 1-Methyleth-1-yl, 1-Methylethyl, Prop-2-yl und iso-Propyl- synonym zu verstehen. 5 „Haloalkyl“, „-alkenyl“ und „-alkinyl“ bedeuten durch gleiche oder verschiedene Halogenatome, teilweise oder vollständig substituiertes Alkyl, Alkenyl bzw. Alkinyl, z.B. Monohaloalkyl (= Monohalogenalkyl) wie z. B. CH2CH2Cl, CH2CH2Br, CHClCH3, CH2Cl, CH2F; Perhaloalkyl wie z. B. CCl3, CClF2, CFCl2,CF2CClF2, CF2CClFCF3; Polyhaloalkyl wie z. B. CH2CHFCl, CF2CClFH, 10 CF2CBrFH, CH2CF3; Der Begriff Perhaloalkyl umfasst dabei auch den Begriff Perfluoralkyl. „Haloalkoxy“ ist z.B. OCF3, OCHF2, OCH2F, OCF2CF3, OCH2CF3 und OCH2CH2Cl; Entsprechendes gilt für Haloalkenyl und andere durch Halogen substituierten Reste. 15 Der hier beispielhaft genannte Ausdruck "(C1-C4)-Alkyl" bedeutet eine Kurzschreibweise für geradkettiges oder verzweigtes Alkyl mit einem bis 4 Kohlenstoffatomen entsprechend der Bereichsangabe für C-Atome, d. h. umfasst die Reste Methyl, Ethyl, 1-Propyl, 2-Propyl, 1-Butyl, 2-Butyl, 2-Methylpropyl oder tert-Butyl. Allgemeine Alkylreste mit einem größeren angegebenen Bereich von C-Atomen, z. B. "(C1-C6)-Alkyl", umfassen entsprechend auch geradkettige oder 20 verzweigte Alkylreste mit einer größeren Zahl von C-Atomen, d. h. gemäß Beispiel auch die Alkylreste mit 5 und 6 C-Atomen. Wenn nicht speziell angegeben, sind bei den Kohlenwasserstoffresten wie Alkyl-, Alkenyl- und Alkinylresten, auch in zusammengesetzten Resten, die niederen Kohlenstoffgerüste, z.B. mit 1 bis 6 25 C-Atomen bzw. bei ungesättigten Gruppen mit 2 bis 6 C-Atomen, bevorzugt. Alkylreste, auch in den zusammengesetzten Resten wie Alkoxy, Haloalkyl usw., bedeuten z.B. Methyl, Ethyl, n- oder i-Propyl, n-, i-, t- oder 2-Butyl, Pentyle, Hexyle, wie n-Hexyl, i-Hexyl und 1,3-Dimethylbutyl, Heptyle, wie n-Heptyl, 1-Methylhexyl und 1,4-Dimethylpentyl; Alkenyl- und Alkinylreste haben die Bedeutung der den Alkylresten entsprechenden möglichen ungesättigten Reste, wobei mindestens eine Doppelbindung 30 bzw. Dreifachbindung enthalten ist. Bevorzugt sind Reste mit einer Doppelbindung bzw. Dreifachbindung. Der Begriff „Alkenyl“ schließt insbesondere auch geradkettige oder verzweigte offenkettige Kohlenwasserstoffreste mit mehr als einer Doppelbindung ein, wie 1,3-Butadienyl und 1,4-Pentadienyl, 35 aber auch Allenyl- oder Kumulenyl-reste mit einer bzw. mehreren kumulierten Doppelbindungen, wie beispielsweise Allenyl (1,2-Propadienyl), 1,2-Butadienyl und 1,2,3-Pentatrienyl. Alkenyl bedeutet z.B. Vinyl, welches ggf. durch weitere Alkylreste substituiert sein kann, z B. (aber nicht beschränkt auf) BCS241005-Ausland STR 59 (C2-C6)-Alkenyl wie Ethenyl, 1-Propenyl, 2-Propenyl, 1-Methylethenyl, 1-Butenyl, 2-Butenyl, 3- Butenyl, 1-Methyl-1-propenyl, 2-Methyl-1-propenyl, 1-Methyl-2-propenyl, 2-Methyl-2-propenyl, 1- Pentenyl, 2-Pentenyl, 3-Pentenyl, 4-Pentenyl, 1-Methyl-1-butenyl, 2-Methyl-1-butenyl, 3-Methyl-1- butenyl, 1-Methyl-2-butenyl, 2-Methyl-2-butenyl, 3-Methyl-2-butenyl, 1-Methyl-3-butenyl, 2-Methyl-3- 5 butenyl, 3-Methyl-3-butenyl, 1,1-Dimethyl-2-propenyl, 1,2-Dimethyl-1-propenyl, 1,2-Dimethyl-2- propenyl, 1-Ethyl-1-propenyl, 1-Ethyl-2-propenyl, 1-Hexenyl, 2-Hexenyl, 3-Hexenyl, 4-Hexenyl, 5- Hexenyl, 1-Methyl-1-pentenyl, 2-Methyl-1-pentenyl, 3-Methyl-1-pentenyl, 4-Methyl-1-pentenyl, 1- Methyl-2-pentenyl, 2-Methyl-2-pentenyl, 3-Methyl-2-pentenyl, 4-Methyl-2-pentenyl, 1-Methyl-3- pentenyl, 2-Methyl-3-pentenyl, 3-Methyl-3-pentenyl, 4-Methyl-3-pentenyl, 1-Methyl-4-pentenyl, 2-10 Methyl-4-pentenyl, 3-Methyl-4-pentenyl, 4-Methyl-4-pentenyl, 1,1-Dimethyl-2-butenyl, 1,1-Dimethyl- 3-butenyl, 1,2-Dimethyl-1-butenyl, 1,2-Dimethyl-2-butenyl, 1,2-Dimethyl-3-butenyl, 1,3-Dimethyl-1- butenyl, 1,3-Dimethyl-2-butenyl, 1,3-Dimethyl-3-butenyl, 2,2-Dimethyl-3-butenyl, 2,3-Dimethyl-1- butenyl, 2,3-Dimethyl-2-butenyl, 2,3-Dimethyl-3-butenyl, 3,3-Dimethyl-1-butenyl, 3,3-Dimethyl-2- butenyl, 1-Ethyl-1-butenyl, 1-Ethyl-2-butenyl, 1-Ethyl-3-butenyl, 2-Ethyl-1-butenyl, 2-Ethyl-2-butenyl,15 2-Ethyl-3-butenyl, 1,1,2-Trimethyl-2-propenyl, 1-Ethyl-1-methyl-2-propenyl, 1-Ethyl-2-methyl-1- propenyl und 1-Ethyl-2-methyl-2-propenyl. Der Begriff „Alkinyl“ schließt insbesondere auch geradkettige oder verzweigte offenkettige Kohlenwasserstoffreste mit mehr als einer Dreifachbindung oder auch mit einer oder mehreren 20 Dreifachbindungen und einer oder mehreren Doppelbindungen ein, wie beispielsweise 1,3-Butatrienyl bzw.3-Penten-1-in-1-yl. (C2-C6)-Alkinyl bedeutet z.B. Ethinyl, 1-Propinyl, 2-Propinyl, 1-Butinyl, 2- Butinyl, 3-Butinyl, 1-Methyl-2-propinyl, 1-Pentinyl, 2-Pentinyl, 3-Pentinyl, 4-Pentinyl, 1-Methyl-2- butinyl, 1-Methyl-3-butinyl, 2-Methyl-3-butinyl, 3-Methyl-1-butinyl, 1,1-Dimethyl-2-propinyl, 1-Ethyl- 2-propinyl, 1-Hexinyl, 2-Hexinyl, 3-Hexinyl, 4-Hexinyl, 5-Hexinyl, 1-Methyl-2-pentinyl, 1-Methyl-3-25 pentinyl, 1-Methyl-4-pentinyl, 2-Methyl-3-pentinyl, 2-Methyl-4-pentinyl, 3-Methyl-1-pentinyl, 3- Methyl-4-pentinyl, 4-Methyl-1-pentinyl, 4-Methyl-2-pentinyl, 1,1-Di-methyl-2-butinyl, 1,1-Dimethyl-3- butinyl, 1,2-Dimethyl-3-butinyl, 2,2-Dimethyl-3-butinyl, 3,3-Dimethyl-1-butinyl, 1-Ethyl-2-butinyl, 1- Ethyl-3-butinyl, 2-Ethyl-3-butinyl und 1-Ethyl-1-methyl-2-propinyl. 30 Der Begriff „Cycloalkyl“ bedeutet ein carbocyclisches, gesättigtes Ringsystem mit vorzugsweise 3-8 Ring-C-Atomen, z.B. Cyclopropyl, Cyclobutyl, Cyclopentyl oder Cyclohexyl, das gegebenenfalls weiter substituiert ist, bevorzugt durch Wasserstoff, Alkyl, Alkoxy, Oxo, Cyano, Nitro, Alkylthio, Haloalkylthio, Halogen, Alkenyl, Alkinyl, Haloalkyl, Amino, Alkylamino, Bisalkylamino, Alkocycarbonyl, Hydroxycarbonyl, Arylalkoxycarbonyl, Aminocarbonyl, Alkylaminocarbonyl, 35 Cycloalkylaminocarbonyl. Im Falle von gegebenenfalls substituiertem Cycloalkyl werden cyclische Systeme mit Substituenten umfasst, wobei auch Substituenten mit einer Doppelbindung am Cycloalkylrest, z. B. eine Alkylidengruppe wie Methyliden, umfasst sind. Im Falle von gegebenenfalls BCS241005-Ausland STR 60 substituiertem Cycloalkyl werden auch mehrcyclische aliphatische Systeme umfasst, wie beispielsweise Bicyclo[1.1.0]butan-1-yl, Bicyclo[1.1.0]butan-2-yl, Bicyclo[2.1.0]pentan-1-yl, Bicyclo[1.1.1]pentan-1- yl, Bicyclo[2.1.0]pentan-2-yl, Bicyclo[2.1.0]pentan-5-yl, Bicyclo[2.1.1]hexyl, Bicyclo[2.2.1]hept-2-yl, Bicyclo[2.2.2]octan-2-yl, Bicyclo[3.2.1]octan-2-yl, Bicyclo[3.2.2]nonan-2-yl, Adamantan-1-yl und 5 Adamantan-2-yl, aber auch Systeme wie z. B.1,1'-Bi(cyclopropyl)-1-yl, 1,1'-Bi(cyclopropyl)-2-yl. Der Ausdruck "(C3-C7)-Cycloalkyl" bedeutet eine Kurzschreibweise für Cycloalkyl mit drei bis 7 Kohlenstoffatomen entsprechend der Bereichsangabe für C-Atome. Im Falle von substituiertem Cycloalkyl werden auch spirocyclische aliphatische Systeme umfasst, wie 10 beispielsweise Spiro[2.2]pent-1-yl, Spiro[2.3]hex-1-yl, Spiro[2.3]hex-4-yl, 3-Spiro[2.3]hex-5-yl, Spiro[3.3]hept-1-yl, Spiro[3.3]hept-2-yl. „Cycloalkenyl“ bedeutet ein carbocyclisches, nicht aromatisches, partiell ungesättigtes Ringsystem mit vorzugsweise 4-8 C-Atomen, z.B.1-Cyclobutenyl, 2-Cyclobutenyl, 1-Cyclopentenyl, 2-Cyclopentenyl, 15 3-Cyclopentenyl, oder 1-Cyclohexenyl, 2-Cyclohexenyl, 3-Cyclohexenyl, 1,3-Cyclohexadienyl oder 1,4-Cyclohexadienyl, wobei auch Substituenten mit einer Doppelbindung am Cycloalkenylrest, z. B. eine Alkylidengruppe wie Methyliden, umfasst sind. Im Falle von gegebenenfalls substituiertem Cycloalkenyl gelten die Erläuterungen für substituiertes Cycloalkyl entsprechend. 20 Der Begriff „Alkyliden“, z. B. auch in der Form (C1-C10)-Alkyliden, bedeutet den Rest eines geradkettigen oder verzweigten offenkettigen Kohlenwasserstoffrests, der über eine Zweifachbindung gebunden ist. Als Bindungsstelle für Alkyliden kommen naturgemäß nur Positionen am Grundkörper in Frage, an denen zwei H-Atome durch die Doppelbindung ersetzt werden können; Reste sind z. B. =CH2, =CH-CH3, =C(CH3)-CH3, =C(CH3)-C2H5 oder =C(C2H5)-C2H5. Cycloalkyliden bedeutet ein 25 carbocyclischer Rest, der über eine Zweifachbindung gebunden ist. „Cycloalkylalkyloxy“ bedeutet ein über ein Sauerstoffatom gebundenen Cycloalkylalkylrest und „Arylalkyloxy“ bedeutet ein über ein Sauerstoffatom gebundenen Arylalkylrest. 30 „Alkoxyalkyl“ steht für einen über eine Alkylgruppe gebundenen Alkoxyrest und „Alkoxyalkoxy“ bedeutet einen über ein Sauerstoffatom gebundenen Alkoxyalkylrest, z.B. (aber nicht beschränkt auf) Methoxymethoxy, Methoxyethoxy, Ethoxyethoxy, Methoxy-n-propyloxy. „Alkylthioalkyl“ steht für einen über eine Alkylgruppe gebundenen Alkylthiorest und 35 „Alkylthioalkylthio“ bedeutet einen über ein Sauerstoffatom gebundenen Alkylthioalkylrest. BCS241005-Ausland STR 61 „Arylalkoxyalkyl“ steht für einen über eine Alkylgruppe gebundenen Aryloxyrest und „Heteroaryloxyalkyl“ bedeutet einen über eine Alkylgruppe gebundenen Heteroaryloxyrest. „Haloalkoxyalkyl“ steht für einen gebundenen Haloalkoxyrest und „Haloalkylthioalkyl“ bedeutet einen 5 über eine Alkylgruppe gebundenen Haloalkylthiorest. „Arylalkyl“ steht für einen über eine Alkylgruppe gebundenen Arylrest, „Heteroarylalkyl“ bedeutet einen über eine Alkylgruppe gebundenen Heteroarylrest, und „Heterocyclylalkyl“ bedeutet einen über eine Alkylgruppe gebundenen Heterocyclylrest. 10 „Cycloalkylalkyl“ steht für einen über eine Alkylgruppe gebundenen Cycloalkylrest, z. B. (aber nicht beschränkt auf) Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, 1- Cyclopropyleth-1-yl, 2-Cyclopropyleth-1-yl, 1-Cyclopropylprop-1-yl, 3-Cyclopropylprop-1-yl. 15 „Arylalkenyl“ steht für einen über eine Alkenylgruppe gebundenen Arylrest, „Heteroarylalkenyl“ bedeutet einen über eine Alkenylgruppe gebundenen Heteroarylrest, und „Heterocyclylalkenyl“ bedeutet einen über eine Alkenylgruppe gebundenen Heterocyclylrest. „Arylalkinyl“ steht für einen über eine Alkinylgruppe gebundenen Arylrest, „Heteroarylalkinyl“ 20 bedeutet einen über eine Alkinylgruppe gebundenen Heteroarylrest, und „Heterocyclylalkinyl“ bedeutet einen über eine Alkinylgruppe gebundenen Heterocyclylrest. Erfindungsgemäß steht "Haloalkylthio" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes S-Halogenalkyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 25 Kohlenstoffatomen, wie (C1-C8)-, (C1-C6)- oder (C1-C4)-Haloalkylthio, z.B. (aber nicht beschränkt auf) Trifluormethylthio oder Trifluormethylsulfanyl, Pentafluorethylthio oder Pentafluorethylsulfanyl, Difluormethyl, 2,2-Difluoreth-1-ylthio, 2,2,2-Difluoreth-1-ylthio, 3,3,3-prop-1-ylthio. „Halocycloalkyl“ und „Halocycloalkenyl“ bedeuten durch gleiche oder verschiedene Halogenatome, wie 30 z. B. F, Cl und Br, oder durch Haloalkyl, wie z. B. Trifluormethyl oder Difluormethyl teilweise oder vollständig substituiertes Cycloalkyl oder Cycloalkenyl , z.B.1-Fluorcycloprop-1-yl, 2-Fluorcycloprop- 1-yl, 2,2-Difluorcycloprop-1-yl, 1-Fluorcyclobut-1-yl, 1-Trifluormethylcycloprop-1-yl, 2- Trifluormethylcycloprop-1-yl, 1-Chlor-cycloprop-1-yl, 2-Chlorcycloprop-1-yl, 2,2-Dichlorcycloprop-1- yl, 3,3-Difluorcyclobutyl, 35 Erfindungsgemäß steht "Trialkylsilyl" oder „Tris(alkyl)silyl“ - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes Si-Alkyl, vorzugsweise mit 1 bis 8, oder BCS241005-Ausland STR 62 mit 1 bis 6 Kohlenstoffatomen, wie Tri-[(C1-C8)-, (C1-C6)- oder (C1-C4)-alkyl]silyl, z.B. (aber nicht beschränkt auf) Trimethylsilyl, Triethylsilyl, Tri-(n-propyl)silyl, Tri-(iso-propyl)silyl, Tri-(n-butyl)silyl, Tri-(1-methylprop-1-yl)silyl, Tri-(2-methylprop-1-yl)silyl, Tri(1,1-Dimethyleth-1-yl)silyl, Tri(2,2- Dimethyleth-1-yl)silyl. 5 „Trialkylsilylalkinyl“ steht für einen über eine Alkinylgruppe gebundenen Trialkylsilylrest. Synthese von substituierten Arylpyrazinen der allgemeinen Formel (I): 10 Die Synthese der erfindungsgemäßen Verbindungen ist im Folgenden beschrieben. Ein zentrales Intermediat stellen Verbindungen der Formel (VII) dar, ihre Synthese ist in WO 2021/069575 ausführlich beschrieben und in Schema 1 dargestellt. Dabei steht der Substituent X1 in Verbindungen der Formel (II) für Chlor, Brom oder Iod. Verbindungen der Formel (II) sind kommerziell erhältlich oder können nach Methoden synthetisiert werden, die in der Literatur gut bekannt sind. Bei der Metallierung15 von (II) in der ortho-Position zu X1 wird mit Intermediat (III) eine Verbindung erhalten, die in ortho- Position zu X1 ein Metallfragment M´ enthält, das aus einem Metall wie beispielsweise Lithium, Magnesium oder Zink sowie geeigneten Liganden besteht (z. B.2,2,6,6-Tetramethylpiperidid). Im Anschluss wird das Intermediat (III) mit einem Aldehyd (IV) versetzt. Im resultierenden Alkohol (V) wird die Hydroxylgruppe durch ein geschütztes Amin substituiert, wodurch man zu dem Intermediat der 20 Formel (VII) gelangt. Bei den Substituenten PG1 und PG2 handelt es sich um Amin-Schutzgruppen, die entweder getrennt voneinander vorliegen können oder aber gemeinsam und zusammen mit dem Stickstoffatom des Amins einen Ring bilden. Je nach Umsetzungsmethode wird die eine oder andere Variante von Schutzgruppe gewählt. Es ist zudem auch möglich, dass einer der Reste PG1 oder PG2 für Wasserstoff steht. Details zu der hier dargelegten Synthese von Verbindungen der Formel (VII) sind in 25 WO 2021/069575 aufgeführt. Schema 1: 30 Ein alternativer Zugang zu den Intermediaten (VII) besteht beispielsweise in der Oxidation des Alkohols (V) zum Keton (VIII), gefolgt von einer reduktiven Aminierung zum Intermediat (IX). Dieses kann am BCS241005-Ausland STR 63 Amin mit geeigneten Schutzgruppen versehen werden und auch hier können die Amin-Schutzgruppen PG1 und PG2 getrennt voneinander vorliegen oder aber gemeinsam und zusammen mit dem Stickstoffatom des Amins einen Ring bilden. Weiterhin kann einer der Reste PG1 oder PG2 für Wasserstoff stehen (Schema 2). Je nach Umsetzungsmethode wird die eine oder andere Variante von 5 Schutzgruppe gewählt. Schema 2: 10 Zum Einbau der Reste M-1, M-2 und M-3 sind Kreuzkupplungen zweckmäßig, in denen die Intermediate (VII) mit solchen Reaktionspartnern der Formeln (X-1), (X-2) und (X-3) zur Umsetzung gebracht werden, die entsprechend der Definitionen der Reste M-1, M-2 und M-3 einen substituierten Arylring tragen (Schema 3). Bei dem Substituenten X2 handelt es sich um für Kreuzkupplungen typische Substituenten wie beispielsweise ein Trialkylstannylrest, einer Boronsäure oder einem Boronsäureester 15 oder aber um ein Metallfragment, das aus einem Metall wie beispielsweise Zink, Nickel oder Magnesium sowie geeigneten Liganden besteht. Kreuzkupplungen werden typischerweise durch Übergangsmetallkatalysatoren wie beispielsweise Palladium oder Kupfer mit geeigneten Liganden wie beispielsweise Phosphinen oder N-heterocyclischen Carbenen katalysiert. Alternativ kann die Kreuzkupplung auch so ausgeführt werden, dass die Rollen von X1 und X2 vertauscht sind. In diesem 20 Fall würde es sich in der Kreuzkupplung bei dem Substituenten X1 beispielsweise um einen Trialkylstannylrest, eine Boronsäure oder einen Boronsäureester oder aber um ein Metallfragment, das aus einem Metall wie beispielsweise Zink, Nickel oder Magnesium sowie geeigneten Liganden besteht, handeln – wobei diese Funktionalität gegebenfalls vorher hergestellt werden muss, beispielsweise aus dem entsprechenden Halogenid. Entsprechend würde es sich bei dem Substituenten X2 um Chlor, Brom, 25 Iod oder ein geeignetes Sulfonat als Abgangsgruppe handeln. Kreuzkupplungen von Pyrazinen sind beispielsweise in WO 2021069575 beschrieben. Kreuzkupplungen von Pyrazinen mit Arylderivaten sind ebenfalls in der Literatur bekannt, beispielsweise bei W. Verboom et al in Org. Biomol. Chem., 2013, 11, 3583. Im Folgeschritt wird das Amin entschützt und anschließend acyliert. Gegebenenfalls wird danach das30 Stickstoffatom der Amidgruppe weiter derivatisiert. Auch die Schritte der Amin-Entschützung, Amin- Acylierung sowie Amid-Derivatisierung sind beispielsweise in WO 2021069575 beschrieben. Schema 3: BCS241005-Ausland STR 64 BCS241005-Ausland STR 65 Die Veresterung zur Einführung der oben definierten Gruppen Q-1 bis Q-480 und Q-482 bis Q-500 kann, wie beispielhaft aber nicht einschränkend in Schema 4 dargestellt, ausgehend von der Säurefunktion Q-481 in der jeweiligen Verbindung der allgemeinen Formel (I) unter Vermittlung geeigneter Kupplungsreagenzien (z. B. HOBt = 1-Hydroxybenzotriazol, EDC = 1-Ethyl-3-(3- 5 dimethylaminopropyl)carbodiimid, HATU = O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′- tetramethyluronium-hexafluorphosphat, T3P = 2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6- trioxid) und geeigneter Basen (z. B. Diisopropylethylamin, Triethylamin) in einem geeigneten Lösemittel (z. B. Dichlormethan, Chloroform, Acetonitril) durchgeführt werden. Alternativ kann die Veresterung über eine Transformation der Gruppe Q-481 in der jeweiligen Verbindung der allgemeinen 10 Formel (I) ins Säurechlorid (XIII-1), (XIII-2) oder (XIII-3) beispielsweise mittels Thionylchlorid und nachfolgender Umsetzung mit dem entsprechenden Alkohol erfolgen, wobei ein geeignetes Lösemittel [z. B. Dichlormethan (DCM), Chloroform, N,N-Dimethylacetamid (DMA) oder N,N- Dimethylformamid (DMF)] Verwendung findet. 15 Schema 4: (XIII-1) BCS241005-Ausland STR 66 (XIII-3) In dem einen oder anderen Reaktionsschritt der in Schema 3 und 4 dargelegten Synthesen muss der Rest 5 Q eventuell angepasst werden, da es sonst am Rest Q möglicherweise zu unerwünschten Reaktionen kommt oder aber weil der Rest Q in bestimmten Formen eine gewünschte Umsetzung an einer anderen Stelle des Moleküls stört. Gegebenenfalls ist es zweckmäßig, eine für die Umsetzungen geeignete Form Q am Ende der Synthesesequenz direkt oder indirekt in die gewünschte Form Q zu überführen. BCS241005-Ausland STR 67 Ausgewählte detaillierte Synthesebeispiele für erfindungsgemäße Verbindungen der allgemeinen Formel (I) sind im Folgenden aufgeführt. Die angegebenen Beispielnummern entsprechen den in den nachstehenden Tabellen I.1 bis I.3 genannten Nummerierungen. Die 1H-NMR-, 13C-NMR- und 19F- NMR-spektroskopischen Daten, die für die in den nachfolgenden Abschnitten beschriebenen 5 chemischen Beispiele angegeben sind, (400 oder 600 MHz bei 1H-NMR und 150 MHz bei 13C-NMR und 375 MHz bei 19F-NMR, Lösungsmittel CDCl3, CD3OD oder d6-DMSO, interner Standard: Tetramethylsilan δ = 0.00 ppm), wurden mit einem Gerät der Firma Bruker erhalten, und die bezeichneten Signale haben die nachfolgend aufgeführten Bedeutungen: br = breit(es); s = Singulett, d = Dublett, t = Triplett, dd = Doppeldublett, ddd = Dublett eines Doppeldubletts, m = Multiplett, q = 10 Quartett, quint = Quintett, sext = Sextett, sept = Septett, dq = Doppelquartett, dt = Doppeltriplett. Bei Diastereomerengemischen werden entweder die jeweils signifikanten Signale beider Diastereomere oder das charakteristische Signal des Hauptdiastereomers angegeben. Die verwendeten Abkürzungen für chemische Gruppen haben beispielsweise die nachfolgenden Bedeutungen: Me = CH3, Et oder Ethyl = CH2CH3, t-Hex = C(CH3)2CH(CH3)2, t-Bu = C(CH3)3, n-Bu = unverzweigtes Butyl, n-Pr oder Prop-1-yl 15 = unverzweigtes Propyl, i-Pr oder Prop-2-yl = verzweigtes Propyl, c-Pr = Cyclopropyl, c-Bu = Cyclobutyl, c-Hex = Cyclohexyl. Synthesebeispiele: 20 Nr. I.1-35: (rac)-Methyl-4-(3-{1-[3-chlor-5-(trifluormethoxy)benzamido]ethyl}pyrazin-2-yl)benzoat Synthesestufe 1: 1-(3-Brompyrazin-2-yl)ethanon Diisopropylamin (73,2 g, 723 mmol, 102 ml, 2,30 Äquivalente) wurde in THF (350 ml) bei -78 °C unter 25 Argonatmosphäre gelöst, n-BuLi (2,50 M, 277 ml, 2,20 Äquivalente) wurde langsam tropfenweise in die Lösung bei -78 °C getropft. Anschließend erwärmte man das Reaktionsgemisch auf -30 °C und rührte 30 Minuten bei dieser Temperatur. Dann wurde die Mischung wieder auf –78 °C abgekühlt.2- Brompyrazin (50,0 g, 315 mmol, 1,00 Äquivalente), gelöst in THF (300 ml), wurde innerhalb von 30 Minuten bei -78 °C in die Mischung zugetropft. N-Methoxy-N-methylacetamid (48,7 g, 472 mmol, 30 50,2). mL, 1,50 Äq.) wurde danach bei -78 °C langsam in das Reaktionsgemisch getropft. Die Reaktionsmischung wurde 1 Stunde lang bei –70 °C gerührt. Die Dünnschichtchromatographie zeigte an, dass 2-Brompyrazin vollständig verbraucht war und sich ein neuer Fleck gebildet hat. Die Reaktionsmischung wurde in eine Mischung aus Eis und einer gesättigten NH4Cl-Lösung (1000 ml) gegossen, die wässrige Phase wurde mit dreimal mit Ethylacetat (á 300,0 ml) extrahiert. Die vereinigten BCS241005-Ausland STR 68 organischen Phasen wurden mit einer gesättigten Kochsalzlösung (300 ml) gewaschen, mit wasserfreiem Na2SO4 getrocknet, filtriert und im Vakuum konzentriert. Der Rückstand wurde durch Säulenchromatographie (SiO2, Petrolether/Ethylacetat = 10/1 bis 3/1) gereinigt.1-(3-Brompyrazin-2- yl)ethanon (35,0 g, 174 mmol, 55,4 % Ausbeute) wurde als gelber Feststoff erhalten.1H NMR (400 5 MHz, CDCl3) δ in ppm: 8.69 - 8.53 (m, 1H), 8.47 (d, J = 2.2 Hz, 1H), 2.84 - 2.56 (m, 3H). Synthesestufe 2: Methyl-4-(3-acetylpyrazin-2-yl)benzoat Eine Lösung von 1-(3-Brompyrazin-2-yl)ethanon (66,2 g, 329 mmol, 1,00 Äquivalente) in Dioxan (330 10 ml) und Wasser (66 ml) wurde unter Stickstoffatmosphäre mit K3PO4 (139 g, 658 mmol, 2,00 Äquivalente) und [4-(Methoxycarbonyl)phenyl]boronsäure (65,2 g, 362 mmol, 1,10 Äq.) und Pd(dppf)Cl2 (24,1 g, 32,9 mmol, 0,100 Äq.) versetzt. Die Reaktionsmischung wurde 16 Stunden lang bei 100 °C gerührt. TLC (Petroleumether:Ethylacetat = 5:1, Rf = 0,25) zeigte, dass 1-(3-Brompyrazin-2- yl)ethanon vollständig verbraucht war und sich ein neuer Fleck gebildet hat. Die Reaktionsmischung 15 wurde mit 200 ml Wasser verdünnt und dreimal mit Ethylacetat (á 200 ml) extrahiert. Die vereinigten organischen Phasen wurden mit einer gesättigten Natriumchlorid-Lösung (200 ml) gewaschen, über Na2SO4 getrocknet, filtriert und unter reduziertem Druck eingeengt. Der Rückstand wurde durch Säulenchromatographie (SiO2, Petrolether/Ethylacetat = 10/1 bis 4/1) gereinigt. Methyl-4-(3- acetylpyrazin-2-yl)benzoat (75,0 g, 292 mmol, 88,8 % Ausbeute) wurde als gelber Feststoff erhalten. 20 1H NMR (400 MHz, CDCl3) δ in ppm: 8.76 (br s, 1H), 8.61 (br s, 1H), 8.23 - 8.02 (m, 2H), 7.75 - 7.54 (m, 2H), 3.95 (s, 3H), 2.70 (d, J = 1.5 Hz, 3H). Synthesestufe 3: (rac)-Methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoat 25 Zu einer Lösung von (rac)-Methyl-4-(3-acetylpyrazin-2-yl)benzoat (70,0 g, 273 mmol, 1,00 Äq.) und NH4OAc (126 g, 1,64 mol, 6,00 Äq.) in MeOH (350 ml) bei 20 °C, 1 Stunde bei 20 °C gerührt, NaBH3CN ( 68,6 g, 1,09 mol, 4,00 Äquivalente) in NH3^H2O (117 ml) wurden zugegeben. Die Mischung wurde 16 Stunden lang bei 55 °C gerührt. Die Reaktionslösung wurde unter vermindertem BCS241005-Ausland STR 69 Druck konzentriert. (rac)-Methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoat (75,0 g, roh) wurde als gelbes Öl (75,0 g, roh) erhalten und ohne weitere Aufreinigung in der nächsten Synthesestufe eingesetzt. Synthesestufe 4: (rac)-Methyl-4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoat 5 Zu einer Lösung von Methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoat (70,0 g, 272 mmol, 1,00 Äq.) in THF (350 ml) wurde Triethylamin (55,0 g, 544 mmol, 75,7 ml, 2,00 Äq.) und danach Boc2O (71,2 g, 326 mmol, 75,0 ml), 1,20 Äq.) zugetropft. Die Mischung wurde 16 Stunden lang bei 20 °C gerührt. Die Reaktionsmischung wurde dann mit 200 ml Wasser verdünnt und dreimal mit Ethylacetat (á 200 ml) 10 extrahiert. Die vereinigten organischen Phasen wurden mit gesättigtem Natriumchlorid (200 ml) gewaschen, über Na2SO4 getrocknet, filtriert und unter reduziertem Druck eingeengt. Der Rückstand wurde durch Säulenchromatographie (SiO2, Petrolether/Ethylacetat = 5/1 bis 0/1) gereinigt. (rac)- Methyl-4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoat (45,0 g, 125 mmol, 46,2 % Ausbeute) wurde als gelber Feststoff erhalten.1H NMR (400 MHz, CDCl3) δ in ppm: 8.83 - 8.47 (m, 15 2H), 8.19 (d, J = 8.1 Hz, 2H), 7.71 (br d, J = 7.8 Hz, 2H), 5.77 - 5.46 (m, 1H), 5.32 - 5.00 (m, 1H), 3.97 (s, 3H), 1.57 - 1.35 (m, 9H), 1.29 (br d, J = 6.1 Hz, 3H). Synthesestufe 5: (rac)-Methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoathydrochlorid 20 Zu einer Lösung von (rac)-Methyl-4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoat (42,1 g, 118 mmol, 1,00 Äq.) in DCM (200 ml) wurde HCl/Dioxan (4 M, 421 ml, 1,00 Äq.) gegeben. Das Rohprodukt wurde 0,5 Stunden lang bei 25 °C mit Ethylacetat verrieben. (rac)-Methyl-4-[3-(1- aminoethyl)pyrazin-2-yl]benzoathydrochlorid (33,3 g, 96,3 % Ausbeute) wurde als cremefarbener Feststoff erhalten. BCS241005-Ausland STR 70 1H NMR (400 MHz, DMSO-d6) δ in ppm: 8.87-8.77 (m, 2H), 8.69-8.42 (m, 3H), 8.14 (d, J = 8.1 Hz, 2H), 7.78 (d, J = 8.1 Hz, 2H), 4.58-4.48 (m, 1H), 3.91 (s, 3H), 1.42 (d, J = 6.6 Hz, 3H). Synthesestufe 6: Nr. I.1-35, (rac)-Methyl-4-(3-{1-[3-chlor-5- 5 (trifluormethoxy)benzamido]ethyl}pyrazin-2-yl)benzoat Zu einer gerührten Suspension von (rac)-Methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoathydrochlorid (0,78 g, 2,66 mmol) in Dichlormethan (20 ml) wurde 3-Chlor-5- (Trifluormethoxy)benzoesäure (703 mg, 2,92 mmol), gefolgt von 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimidhydrochlorid (611 mg, 10 3,19 mmol) und 1-Hydroxybenzotriazolhydrat (430 mg, 14 Gew.-% H2O, 2,74 mmol). Triethylamin (1,11 ml, 7,97 mmol) wurde zugegeben, woraufhin die Reaktionsmischung homogen wurde. Die Reaktionsmischung wurde über Nacht bei Raumtemperatur gerührt. Danach wurde eine gesättigte wässrige Natriumbicarbonatlösung zum Reaktionsgemisch gegeben, die resultierenden Phasen getrennt und die wässrige Phase einmal mit Dichlormethan extrahiert. Die vereinigten organischen Phasen 15 wurden unter Vakuum konzentriert und das resultierende Rohprodukt durch Chromatographie über Kieselgel unter Verwendung eines Gradienten aus Heptan und 0–75 % Ethylacetat gereinigt, um (rac)- Methyl-4-(3-{1-[3-chlor-5-(trifluormethoxy)benzamido]ethyl}pyrazin-2-yl)benzoat (1,11 g, >99 % Reinheit, 87 % Ausbeute) zu ergeben in Form eines weißen Feststoffs.1H NMR (400 MHz, DMSO-d6) δ in ppm: 9.15 (d, J = 6.5 Hz, 1H), 8.70–8.66 (m, 2H), 8.08–8.05 (m, 2H), 7.92–7.92 (m, 1H), 7.80–7.79 20 (m, 2H), 7.75–7.74 (m, 1H), 7.69–7.68 (m, 1H), 5.34–5.28 (m, 1H), 3.89 (s, 3H), 1.47 (d, J = 6.8 Hz, 3H). Nr. I.1-36: (rac)-4-(3-{1-[3-Chlor-5-(trifluormethoxy)benzamido]ethyl}pyrazin-2-yl)benzoesäure BCS241005-Ausland STR 71 Zu einer gerührten Lösung von (rac)-Methyl-4-(3-{1-[3-chlor-5-(trifluormethoxy)benzamido]- ethyl}pyrazin-2-yl)benzoat (0,43 g, 0,90 mmol) in THF ( 8 ml) und Wasser (4 ml) wurden mit LiOH (64 mg, 2,67 mmol) versetzt und die Reaktionsmischung über Nacht bei Raumtemperatur gerührt. Danach 5 wurde die Reaktion mit einer wässrigen 2 M Salzsäurelösung auf einen pH-Wert von 1 bis 2 angesäuert und mit Ethylacetat extrahiert. Der organische Extrakt wurde mit Kochsalzlösung gewaschen, über wasserfreiem Natriumsulfat getrocknet, filtriert und unter Vakuum konzentriert, um die (rac)-4-(3-{1- [3-Chlor-5-(trifluormethoxy)benzamido]ethyl}pyrazin-2-yl)benzoesäure (0,41 g, >99 % Reinheit, 98 % Ausbeute) als weißen Feststoff zu ergeben.1H NMR (400 MHz, DMSO-d6) δ in ppm: 13.10 (brs, 1H), 10 9.18 (d, J = 6.7 Hz, 1H), 8.69–8.66 (m, 2H), 8.07–8.04 (m, 2H), 7.95–7.94 (m, 1H), 7.79–7.74 (m, 3H), 7.72–7.71 (m, 1H), 5.35–5.28 (m, 1H), 1.47 (d, J = 7.0 Hz, 3H). Nr. I.1-42: (rac)-Pyridin-2-ylmethyl-4-(3-{1-[3,5-bis(trifluormethyl)benzamido]ethyl}pyrazin-2- yl)benzoat 15 Eine Lösung von 2,2,6,6-Tetramethylpiperidin (1.50 eq) in abs. Tetrahydrofuran (1 mL/mmol) wurde unter Argonatmosphäre auf eine Temperatur von -78 °C eingekühlt und tropfenweise mit einer Lösung von n-Butyllithium in abs. N-Hexan (2.5 M, 1.30 eq) versetzt. Das resultierende Reaktionsgemisch wurde 30 Minuten lang bei einer Temperatur von -30 °C gerührt, wieder auf -78 °C gekühlt und 20 tropfenweise mit einer Lösung von 2-Brompyrazin (1.00 eq) in abs. Tetrahydrofuran (0.5 mL/mmol) versetzt. Das resultierende Reaktionsgemisch wurde anschließend 30 Minuten bei einer Temperatur von -78 °C gerührt, und danach erfolgte die tropfenweise Zugabe von einer Lösung von Acetaldehyd (2.00 eq) in abs. Tetrahydrofuran (0.5 mL/mmol), und das erhaltene Reaktionsgemisch wurde 60 Minuten BCS241005-Ausland STR 72 lang bei einer Temperatur von -78 °C nachgerührt. Nach vollständigem Umsatz (Dünnschichtchromatographie und LC-MS-Kontrolle) wurde das Reaktionsgemisch mit wäßriger NH4Cl-Lösung versetzt und mehrfach gründlich mit EtOAc extrahiert. Die vereinigten organischen Phasen wurden mit gesättigter NaCl-Lösung gewaschen, über Na2SO4 getrocknet, abfiltriert und unter 5 vermindertem Druck eingeengt. Der verbliebene Rückstand wurde säulenchromatographisch gereinigt (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) und 1-(3-Brompyrazin-2-yl)ethanol wurde in Form eines dunkel gelblichen Öls erhalten.1-(3-Brompyrazin-2-yl)ethanol (1.00 eq) wurde in abs. Tetrahydrofuran (1.5 mL/mmol) gelöst, mit Isoindolin-1,3-dion (1.00 eq) und Triphenylphosphin (1.50 eq) versetzt, 10 Minuten lang bei Raumtemperatur gerührt und auf 0 °C eingekühlt. Danach erfolgte die Zugabe von 10 Azodicarbonsäurediisopropylester (1.50 eq). Nach vollständigem Umsatz nach Erwärmen auf Raumtemperatur (Reaktionskontrolle über Dünnschichtchromatographie) wurde das Reaktionsgemisch abfiltriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbliebenen Rückstandes (SiO2, Gradient Hexan/Ethylacetat) wurde 2-[3-(1-Hydroxyethyl)pyrazin-2- yl]-1H-isoindol-1,3(2H)-dion in Form eines farblosen Feststoffs erhalten. Im nächsten Schritt wurde 2- 15 [3-(1-Hydroxyethyl)pyrazin-2-yl]-1H-isoindol-1,3(2H)-dion (1.00 eq) in abs. MeOH gelöst und bei Raumtemperatur tropfenweise mit Hydrazinhydrat (5.00 eq) versetzt. Das resultierende Reaktionsgemisch wurde 1 h lang unter Rückflußbedingungen gerührt, und nach vollständigem Umsatz (Reaktionskontrolle über LCMS) wurde das Reaktionsgemisch vorsichtig unter vermindertem Druck eingeengt und ohne weitere Reinigung in einem Gemisch aus Tetrahydrofuran und H2O (1:1) gelöst. 20 Danach wurden Na2CO3 (3.00 eq) und Boc2O (5.00 eq) zugegeben und das resultierende Reaktionsgemisch 12 h lang bei Raumtemperatur gerührt. Nach vollständigem Umsatz (Reaktionskontrolle mit LCMS) wurde das Reaktionsgemisch gründlich mit EtOAc extrahiert (100 mL x 3), mit wäßriger NaCl-Lösung (100 mL) gewaschen, über Na2SO4 getrocknet, abflitriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbliebenen 25 Rückstandes (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) wurde tert-Butyl-[1-(3-brompyrazin-2- yl)ethyl]carbamat in Form eines farblosen Feststoffs erhalten. Eine Lösung von Methyl-4-brombenzoat (1.00 eq) wurde in einem ausgeheizten Rundkolben unter Argon in abs. Dioxan gelöst und mit Hexamethyldistannan (1.00 eq) sowie Pd(PPh3)4 (1 equiv) versetzt. Das resultierende Reaktionsgemisch wurde 12 h lang bei einer Temperatur von 90 °C gerührt und nach dem Abkühlen auf Raumtemperatur 30 über Celite abfiltriert, mit Ethylacetat nachgewaschen und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbliebenen Rückstandes (SiO2, Gradient Heptan/Ethylacetat) wurde Methyl-4-(trimethylstannyl)benzoat in Form eines leicht gelblichen viskosen Öls erhalten. tert-Butyl-[1-(3-brompyrazin-2-yl)ethyl]carbamat (1.00 eq) wurde in einem ausgeheizten Rundkolben unter Argon in abs. Toluol gelöst und mit Methyl-4-(trimethylstannyl)benzoat (1.00 eq) 35 sowie Pd(PPh3)4 (0.40 eq) versetzt. Das resultierende Reaktionsgemisch wurde unter Rückflußbedingungen 14 h lang unter Argon gerührt. Der Reaktionsfortschritt wurde mit LCMS überprüft, und nach vollständigem Umsatz der Startmaterialien wurde das Reaktionsgemisch auf BCS241005-Ausland STR 73 Raumtemperatur abgekühlt, mit EtOAc extrahiert (100 mL x 3), mit wäßriger NaCl-Lösung (100 mL) gewaschen, über Na2SO4 getrocknet, abflitriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbliebenen Rückstandes (SiO2, Gradient n- Heptan/Ethylacetat) wurde Methyl-4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoat in 5 Form eines schwach gelblichen Feststoffes erhalten. Methyl-4-(3-{1-[(tert- butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoat (1.00 eq) wurde danach in HCl/Dioxan und Dichlormethan gelöst und 12 h lang bei Raumtemperatur gerührt. Das Reaktionsgemisch wurde danach unter vermindertem Druck eingeengt und der verbliebene Rückstand aus Ethylacetat (50.0 mL) umkristallisiert. Auf diese Weise wurde Methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoat in Form eines 10 gelblichen Feststoffs erhalten (86 % der Theorie) Methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoat kann dadurch auch in Form des HCl-Salzes vorliegen und als solches in Folgeschritten eingesetzt und durch die verwendete Base, z.B. Triethylamin, freigesetzt werden. Methyl-4-[3-(1-aminoethyl)pyrazin- 2-yl]benzoat (2000 mg, 7.77 mmol, 1.00 eq) wurde unter Argon in einem ausgeheizten Rundkolben in abs. Dichlormethan (50 mL) gelöst und nach 5 Minuten Rühren bei Raumtemperatur mit Triethylamin 15 (2.71 mL, 19.40 mmol, 3.0 eq), 3,5-bis(Trifluormethyl)benzoesäure (2006 mg, 7.77 mmol, 1.00 eq) und Propanphosphonsäureanhydrid 50% in Tetrahydrofuran (5.78 mL, 9.71 mmol, 1.5 eq) versetzt. Das resultierende Reaktionsgemisch wurde 14 h lang bei Raumtemperatur gerührt, danach mit Dichlormethan versetzt und mit verd. HCl (1M) gewaschen. Die organische Phase wurde über Natriumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeengt. Durch 20 säulenchromatographische Reinigung des Rohproduktes (Gradient Heptan/Ethylacetat) wurde Methyl-4- (3-{1-[3,5-bis(trifluormethyl)benzamido]ethyl}pyrazin-2-yl)benzoat (I.1-1) in Form eines farblosen Feststoffs erhalten (1240 mg, 32 % der Theorie). Im nächsten Schritt wurde Methyl-4-(3-{1-[3,5- bis(trifluormethyl)benzamido]ethyl}pyrazin-2-yl)benzoat (1200 mg, 2.41 mmol, 1.00 eq) in einem Gemisch aus Tetrahydrofuran und Wasser (1:1) gelöst und mit Natronlauge (4M, 9.65 mmol, 4.00 eq) 25 versetzt. Das resultierende Reaktionsgemisch wurde danach über Nacht bei Raumtemperatur gerührt, unter vermindertem Druck eingeengt, mit verdünnter HCl (10%ig) sauer gestellt und mit Ethylacetat versetzt. Die wäßrige Phase wurde gründlich mit Ethylacetat extrahiert und die vereinigten organischen Phasen über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des Rohproduktes (Gradient Heptan/Ethylacetat) wurde 4-(3-{1- 30 [3,5-Bis(trifluormethyl)benzamido]ethyl}pyrazin-2-yl)benzoesäure (I.1-2) in Form eines farblosen Feststoffs erhalten (1000 mg, 86 % der Theorie).4-(3-{1-[3,5- Bis(trifluormethyl)benzamido]ethyl}pyrazin-2-yl)benzoesäure (120 mg, 0.24 mmol, 1.0 eq), 1- Hydroxybenzotriazol (42 mg, 0.31 mmol, 1.3 eq) und 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimid hydrochlorid (60 mg, 0.31 mmol, 1.3 eq) wurden in abs. Dichlormethan (5 mL) gelöst und nach 535 Minuten Rühren bei Raumtemperatur mit Triethylamin (0.10 mL, 0.72 mmol, 3.0 equiv) sowie 2- Hydroxymethylpyridin (0.06 mL, 0.31 mmol, 1.3 eq) versetzt. Das resultierende Reaktionsgemisch wurde 6 h lang bei Raumtemperatur gerührt, danach mit Wasser und Dichlormethan versetzt und BCS241005-Ausland STR 74 gründlich extrahiert. Die vereinigten organischen Phasen wurden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des Rohproduktes (Gradient Heptan/Ethylacetat) wurde (rac)-Pyridin-2-ylmethyl-4-(3-{1-[3,5- bis(trifluormethyl)benzamido]ethyl}pyrazin-2-yl)benzoat (I.1-42) in Form eines farblosen Feststoffs 5 erhalten (87 mg, 59 % der Theorie).1H-NMR (400 MHz, CDCl3): Peakpicking δ= 8.6652 (8.1); 8.6469 (4.1); 8.6371 (4.2); 8.6090 (7.5); 8.3224 (7.8); 8.3029 (8.6); 8.2499 (14.7); 8.0154 (6.8); 7.7731 (9.9); 7.7533 (11.3); 7.5039 (4.6); 7.4830 (4.7); 7.4538 (2.7); 7.2874 (2.5); 7.2626 (19.9); 5.7156 (2.1); 5.6973 (3.2); 5.6803 (2.1); 5.5829 (0.8); 5.5430 (13.0); 5.5074 (0.8); 5.2997 (5.1); 4.1463 (0.6); 4.1305 (1.5); 4.1132 (1.5); 4.0947 (0.5); 2.1192 (0.6); 2.0450 (6.4); 1.6096 (16.0); 1.4543 (12.6); 1.4374 (12.8); 10 1.2772 (2.5); 1.2592 (5.6); 1.2415 (2.2); 0.8799 (1.0); -0.0002 (20.2). Nr. I.1-81: (+)-Pyridin-2-ylmethyl-4-(3-{1-[3,5-bis(trifluormethyl)benzamido]ethyl}pyrazin-2- yl)benzoat und Nr. I.1-82: (-)-Pyridin-2-ylmethyl-4-(3-{1-[3,5-bis(trifluormethyl)benzamido]ethyl}- pyrazin-2-yl)benzoat 15 Die oben beschriebene Veresterung von (I.1-2) wurde in vergrößertem Maßstab (1.54 mmol) wiederholt. Daraufhin wurde das auf diese Weise erhaltene racemische Pyridin-2-ylmethyl-4-(3-{1-[3,5- 20 bis(trifluormethyl)benzamido]ethyl}pyrazin-2-yl)benzoat (I.1-42) (400 mg) mit Hilfe eines chiralen präparativen SFC-Systems unter Verwendung einer S10-Chiralpak IF-B1-Säule (Gradient Chir_C4_IF_B1_90CO2_MeOH_CD) in die Enantiomere getrennt. I.1-81 (Ent-1, 135 mg, Retentionszeit 1.41 min, spezifischer Drehwert +123.30°) und I.1-82 (Ent-2, 145 mg, Retentionszeit 1.48 min, spezifischer Drehwert -115.30°) wurden dabei in Form von farblosen Feststoffen isoliert. I.1-81: 1H-NMR 25 (400 MHz, CDCl3): ^ 8.68 (s, 1H). 8.67-8.64 (m, 1H), 8.62 (s, 1H), 8.33-8.30 (d, 2H), 8.25 (s, 2H), 8.02 (s, 1H), 7.79-7.75 (m, 3H), 7.52-7.50 (d, 1H), 7.47-7.45 (d, 1H), 7.30-7.27 (m, 1H), 5.73-5.66 (quint, 1H), 5.59-5.55 (d, 1H), 5.56-5.52 (d, 1H), 1.46-1.44 (d, 3H). I.1-82: 1H-NMR (400 MHz, CDCl3): ^ 8.69 (s, 1H). 8.67-8.64 (m, 1H), 8.63 (s, 1H), 8.32-8.30 (d, 2H), 8.25 (s, 2H), 8.02 (s, 1H), 7.80-7.75 (m, 3H), BCS241005-Ausland STR 75 7.52-7.50 (d, 1H), 7.47-7.45 (d, 1H), 7.30-7.27 (m, 1H), 5.73-5.66 (quint, 1H), 5.59-5.55 (d, 1H), 5.56- 5.52 (d, 1H), 1.46-1.44 (d, 3H). Nr. I.1-68: (rac)-Methyl-4-{3-[1-(3,4-dichlorbenzamido)ethyl]pyrazin-2-yl}benzoat 5 10 Methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoat (200 mg, 0.78 mmol, 1.00 eq) wurde in abs. Dichlormethan (3 mL) bei Raumtemperatur mit Triethylamin (0.33 mL, 2.33 mmol, 3.0 eq) versetzt, 15 anschließend wurde das Reaktionsgemisch auf eine Temperatur von 0 °C – 5 °C abgekühlt. Danach wurde eine Lösung von 3,4-Dichlorbenzoylchlorid (171 mg, 0.82 mmol, 1.05 eq) in wenig Dichlormethan innerhalb von fünf Minuten tropfenweise zugegeben. Das resultierende Reaktionsgemisch wurde 16 h lang bei Raumtemperatur gerührt. Zur Aufarbeitung wurde das Reaktionsgemisch unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung20 des Rohproduktes (Gradient Heptan/Ethylacetat) wurde (rac)-Methyl-4-{3-[1-(3,4- dichlorbenzamido)ethyl]pyrazin-2-yl}benzoat (I.1-68) erhalten (212 mg, 63 % der Theorie).1H- NMR(400.6 MHz, CDCl3): δ= 8.6450 (2.7); 8.6390 (3.2); 8.5909 (3.0); 8.5849 (2.4); 8.2296 (3.6); 8.2086 (3.9); 7.9060 (2.8); 7.9009 (2.8); 7.7410 (3.9); 7.7201 (3.6); 7.6504 (1.3); 7.6453 (1.2); 7.6296 (1.8); 7.6245 (1.7); 7.5309 (3.1); 7.5102 (2.2); 7.3202 (0.8); 7.3014 (0.8); 7.2619 (8.5); 5.6706 (0.9); 25 5.6533 (1.1); 5.6346 (0.8); 3.9722 (16.0); 1.6082 (0.6); 1.4085 (6.2); 1.3918 (6.1); -0.0002 (9.7) Nr. I.1-66: (rac)-4-{3-[1-(3,4-Dichlorbenzamido)ethyl]pyrazin-2-yl}benzoesäure 30 35 BCS241005-Ausland STR 76 Methyl-4-{3-[1-(3,4-dichlorbenzamido)ethyl]pyrazin-2-yl}benzoat (I.1-68) (1.36 g, 3.16 mmol, 1.00 eq) wurde in Methanol (50 mL) mit Natronlauge (5.00 mL, 20-Gew.-%, 31.6 mmol, 10.0 eq) versetzt. Anschließend wurde das Reaktionsgemisch 1 h bei einer Temperatur von 60 °C gerührt. Zur Aufarbeitung wurde das Reaktionsgemisch unter vermindertem Druck eingeengt. Der Rückstand wurde 5 in wenig Wasser aufgenommen, danach wurde das Gemisch mit 6N Salzsäure angesäuert. Der ausgefallene Feststoff wurde abgetrennt und getrocknet. Zur weiteren Aufreinigung wurde der Feststoff mit n-Heptan verrührt und nach der Filtration wurde der Feststoff getrocknet. Dabei wurde (rac)-4-{3- [1-(3,4-Dichlorbenzamido)ethyl]pyrazin-2-yl}benzoesäure (I.1-66) erhalten (1.21 g, 92 % der Theorie). 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0810 (3.5); 9.0645 (3.6); 8.6659 (7.5); 8.6598 (13.6); 8.6466 10 (16.0); 8.6406 (9.2); 8.0710 (9.7); 8.0660 (9.7); 8.0489 (11.0); 8.0444 (3.5); 8.0325 (3.9); 8.0278 (13.0); 8.0238 (1.9); 7.9569 (0.5); 7.9523 (0.6); 7.7942 (4.5); 7.7891 (4.0); 7.7833 (0.5); 7.7733 (7.2); 7.7681 (7.3); 7.7581 (0.7); 7.7453 (10.5); 7.7408 (3.5); 7.7288 (3.5); 7.7244 (9.4); 7.7157 (13.2); 7.6948 (7.8); 5.3296 (2.4); 5.3127 (3.6); 5.2958 (2.3); 3.3327 (2.6); 3.1689 (0.6); 2.6758 (1.0); 2.6711 (1.5); 2.6666 (1.0); 2.6620 (0.5); 2.5417 (3.7); 2.5376 (0.7); 2.5327 (1.1); 2.5249 (4.5); 2.5202 (6.1); 2.5115 (80.2); 15 2.5069 (173.8); 2.5023 (241.9); 2.4978 (165.0); 2.4932 (71.4); 2.3340 (1.0); 2.3294 (1.4); 2.3247 (1.0); 1.4550 (14.1); 1.4378 (14.0); 0.1456 (0.6); 0.0080 (5.5); 0.0062 (1.4); -0.0002 (200.7); -0.0051 (1.7); - 0.0060 (1.4); -0.0069 (1.3); -0.0085 (5.4); -0.1493 (0.6). Nr. I.1-169: (rac)-2-Methoxyethyl-4-{3-[1-(3,4-dichlorbenzamido)ethyl]pyrazin-2-yl}benzoat 20 25 4-{3-[1-(3,4-Dichlorbenzamido)ethyl]pyrazin-2-yl}benzoesäure (I.1-66) (200 mg, 0.48 mmol, 1.00 eq) wurde in Dichlormethan (20 mL) mit 1-Hydroxybenzotriazol (84.4 mg, 0.625 mmol, 1.30 eq), 1-Ethyl- 3-(3-dimethylaminopropyl)carbodiimidhydrochlorid (120 mg, 0.625 mmol, 1.30 eq) und 4-30 Dimethylaminopyridin (0.587 mg, 0.005 mmol, 0.01 eq) versetzt. Anschließend wurde 2- Methoxyethanol (51.2 mg, 0.673 mmol, 1.40 eq) zugegeben. Danach wurde das Reaktionsgemisch 16 h bei Raumtemperatur gerührt. Zur Aufarbeitung wurde die Mischung mit Wasser verrührt und nach der Phasentrennung wurde die organische Phase unter vermindertem Druck eingeengt. Wegen unvollständiger Umsetzung konnte nach säulenchromatographischer Reinigung des Rohproduktes kein 35 sauberes Produkt isoliert werden. Zur Vervollständigung der Umsetzung wurde das nach säulenchromatographischer Reinigung erhaltene Gemisch in Dichlormethan (20 mL) mit 1-Ethyl-3-(3- dimethylaminopropyl)carbodiimidhydrochlorid (120 mg, 0.625 mmol, 1.30 eq) und Triethylamin (97.2 BCS241005-Ausland STR 77 mg, 0.961 mmol, 2.00 eq) versetzt. Anschließend wurde 2-Methoxyethanol (51.2 mg, 0.673 mmol, 1.40 eq) zugegeben. Danach wurde das Reaktionsgemisch 16 h bei Raumtemperatur gerührt. Zur Aufarbeitung wurde das Reaktionsgemisch mit Wasser verrührt und nach der Phasentrennung wurde die organische Phase unter vermindertem Druck vom Lösungsmittel befreit. Durch 5 säulenchromatographische Reinigung des Rohproduktes (Gradient Heptan/Ethylacetat) wurde (rac)-2- Methoxyethyl-4-{3-[1-(3,4-dichlorbenzamido)ethyl]pyrazin-2-yl}benzoat (I.1-169) erhalten (108 mg, 47 % der Theorie).1H-NMR(400.6 MHz, CDCl3): δ= 8.6457 (1.0); 8.6396 (1.3); 8.5899 (1.1); 8.5838 (0.9); 8.2588 (1.2); 8.2376 (1.5); 7.9074 (1.0); 7.9023 (1.1); 7.7420 (1.3); 7.7208 (1.3); 7.6301 (0.7); 7.6249 (0.7); 7.5326 (1.2); 7.5119 (0.9); 7.2606 (24.5); 4.5384 (0.6); 4.5294 (0.7); 4.5244 (0.7); 4.5151 10 (0.6); 3.7754 (0.9); 3.7635 (1.0); 3.7518 (0.9); 3.4588 (7.8); 2.0455 (0.6); 1.5475 (16.0); 1.4014 (2.1); 1.3847 (2.2); 0.0079 (0.9); -0.0002 (29.0); -0.0085 (1.0). Nr. I.1-177: (rac)-Isopropyl-4-{3-[1-(3,4-dichlorbenzamido)ethyl]pyrazin-2-yl}benzoat 15 20 4-{3-[1-(3,4-Dichlorbenzamido)ethyl]pyrazin-2-yl}benzoesäure (I.1-66) (150 mg, 0.36 mmol, 1.00 eq) wurde in Dichlormethan (20 mL) mit 1-Hydroxybenzotriazol (63.3 mg, 0.468 mmol, 1.30 eq) und 1- Ethyl-3-(3-dimethylaminopropyl)carbodiimidhydrochlorid (89.8 mg, 0.468 mmol, 1.30 eq) versetzt. Danach wurde das Reaktionsgemisch 15 Minuten bei Raumtemperatur gerührt. Anschließend wurden 25 nacheinander 2-Propanol (30.3 mg, 0.504 mmol, 1.40 eq) und Triethylamin (72.9 mg, 0.721 mmol, 2.00 eq) zugegeben. Danach wurde das Reaktionsgemisch 16 h bei Raumtemperatur gerührt. Zur Vervollständigung der Reaktion wurden erneut 2-Propanol (30.3 mg, 0.504 mmol, 1.40 eq) und Triethylamin (72.9 mg, 0.721 mmol, 2.00 eq) zugegeben und das Gemisch wurde wieder 16 h bei Raumtemperatur gerührt. Da die analytische Reaktionskontrolle immer noch keine vollständige 30 Umsetzung anzeigte, wurden nochmals 2-Propanol (30.3 mg, 0.504 mmol, 1.40 eq) und Triethylamin (72.9 mg, 0.721 mmol, 2.00 eq) zugegeben. Anschließend wurde der Inhalt 1 h unter Rückfluss und danach fünf Tage bei Raumtemperatur gerührt. Zur Aufarbeitung wurde die Mischung mit Wasser verrührt und nach der Phasentrennung wurde die organische Phase unter vermindertem Druck eingeengt. Nach säulenchromatographischer Reinigung des Rohproduktes (Gradient Heptan/Ethylacetat) wurde der 35 Rückstand in Aceton aufgenommen und die Mischung wurde im Anschluss unter vermindertem Druck wieder bis zur Trockene eingeengt. Es wurde (rac)-Isopropyl-4-{3-[1-(3,4- dichlorbenzamido)ethyl]pyrazin-2-yl}benzoat (I.1-177) erhalten (107 mg, 65 % der Theorie).1H- BCS241005-Ausland STR 78 NMR(400.6 MHz, CDCl3): δ= 8.6478 (2.4); 8.6419 (2.9); 8.5873 (2.7); 8.5815 (2.4); 8.2266 (3.3); 8.2061 (3.8); 7.9079 (2.5); 7.9033 (2.8); 7.7268 (3.6); 7.7062 (3.5); 7.6515 (1.2); 7.6467 (1.2); 7.6308 (1.6); 7.6259 (1.7); 7.5309 (2.7); 7.5102 (2.0); 7.3166 (1.0); 7.2974 (1.0); 7.2610 (12.4); 5.6756 (0.8); 5.6565 (1.2); 5.6390 (0.9); 5.3179 (1.0); 5.3022 (1.3); 5.2866 (1.0); 2.0454 (1.5); 1.5942 (2.4); 1.4152 5 (14.3); 1.3997 (16.0); 1.3881 (6.7); 1.3029 (1.0); 1.2634 (4.7); 1.2420 (1.2); 0.8972 (1.9); 0.8818 (4.7); 0.8641 (2.2); -0.0002 (17.8). Nr. I.1-284: Methyl-4-(3-{[3,5-bis(trifluormethyl)benzamido](cyclopropyl)methyl}pyrazin-2-yl)benzoat 10 Synthesestufe 1: (3-Brompyrazin-2-yl)(cyclopropyl)methanol Eine Lösung von N-Isopropylpropan-2-amin (58.6 g, 579 mmol, 82 mL, 2.30 eq) in abs. Tetrahydrofuran (280 mL) wurde unter Argonatmosphäre auf eine Temperatur von -78 °C eingekühlt und tropfenweise mit einer Lösung von n-Butyllithium in abs. Tetrahydrofuran (2.5 M, 221 mL, 2.20 eq) versetzt. Das 15 resultierende Reaktionsgemisch wurde 30 Minuten lang bei einer Temperatur von -30 °C gerührt, wieder auf -78 °C gekühlt und tropfenweise mit einer Lösung von 2-Brompyrazin (40.0 g, 252 mmol, 1.00 eq) in abs. Tetrahydrofuran (120 mL) versetzt. Das resultierende Reaktionsgemisch wurde anschließend 30 Minuten bei einer Temperatur von -78 °C gerührt, und danach erfolgte die tropfenweise Zugabe von einer Lösung von Cyclopropancarbaldehyd (35.3 g, 503 mmol, 37.6 mL, 2.20 eq) in abs. Tetrahydrofuran (40.0 20 mL), und das Reaktionsgemisch wurde 60 Minuten lang bei einer Temperatur von -78 °C nachgerührt. Nach vollständigem Umsatz (Dünnschichtchromatographie und LC-MS-Kontrolle) wurde das Reaktionsgemisch mit wäßriger NH4Cl-Lösung (500 mL) versetzt und mehrfach mit EtOAc extrahiert (200 mL x 3). Die vereinigten organischen Phasen wurden mit gesättigter NaCl-Lösung gewaschen (200 mL), über Na2SO4 getrocknet, abfiltriert und unter vermindertem Druck eingeengt. Der verbliebene 25 Rückstand wurde säulenchromatographisch gereinigt (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) und (3-Brompyrazin-2-yl)(cyclopropyl)methanol (45.0 g, 78 % der Theorie) wurde in Form eines gelblichen Öls erhalten. Synthesestufe 2: 3-Brompyrazin-2-yl)(cyclopropyl)methanon 30 (3-Brompyrazin-2-yl)(cyclopropyl)methanol (45.0 g, 196 mmol, 1.00 eq) wurde in abs. Dichlormethan (315 mL) gelöst, mit Pyridiniumchlorochromat (PCC, 84.7 g, 393 mmol, 2.00 eq) versetzt und 12 h lang BCS241005-Ausland STR 79 bei Raumtemperatur gerührt. Nach vollständigem Umsatz (Reaktionskontrolle über Dünnschichtchromatographie) wurde das Reaktionsgemisch abfiltriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbliebenen Rückstandes (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) wurde 3-Brompyrazin-2-yl)(cyclopropyl)methanon (24.0 g, 54 % 5 der Theorie) in Form eines gelben Feststoffs erhalten. 1H-NMR (400 MHz, CDCl3): δ (ppm) = 8.51-8.55 (m, 1H) 8.38-8.42 (m, 1H) 2.76-2.85 (m, 1H), 1.29 (m, 2H), 1.06-1.14 (m, 2H). Synthesestufe 3: tert-Butyl-[(3-brompyrazin-2-yl)(cyclopropyl)methyl]carbamat 10 Im nächsten Schritt wurde Ammoniumacetat (91.7 g, 1.19 mol, 15.0 eq) zu einer Lösung von 3- Brompyrazin-2-yl)(cyclopropyl)methanon (18.0 g, 79.3 mmol, 1.00 eq) in abs. MeOH (126 mL) bei Raumtemperatur gegeben. Das resultierende Reaktionsgemisch wurde 2 h lang bei einer Temperatur von 60 °C gerührt, danach mit NaBH3CN (49.8 g, 793 mmol, 10.0 eq) versetzt und 10 h bei einer Temperatur von 60°C weiter gerührt. Nach vollständigem Umsatz (Reaktionskontrolle über LCMS) wurde das 15 Reaktionsgemisch unter vermindertem Druck eingeengt und das in Form eines gelben Feststoffs erhaltene 1-(3-Brompyrazin-2-yl)-1-cyclopropylmethanamin (18.0 g, 78.9 mmol, 1.00 eq) wurde ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt und in einem Gemisch aus Tetrahydrofuran (36.0 mL) und H2O (54.0 mL) gelöst. Danach wurden Na2CO3 (25.1 g, 237 mmol, 3.00 eq) und Boc2O (25.8 g, 118 mmol, 1.50 eq) zugegeben und das resultierende Reaktionsgemisch 12 h lang bei Raumtemperatur gerührt. 20 Nach vollständigem Umsatz (Reaktionskontrolle mit LCMS) wurde das Reaktionsgemisch gründlich mit EtOAc extrahiert (100 mL x 3), mit wäßriger NaCl-Lösung (100 mL) gewaschen, über Na2SO4 getrocknet, abflitriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbliebenen Rückstandes (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) wurde tert-Butyl-[(3- brompyrazin-2-yl)(cyclopropyl)methyl]carbamat (11.0 g, 43 % der Theorie) in Form eines farblosen 25 Feststoffs erhalten. Synthesestufe 4: Methyl-4-(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)methyl}pyrazin-2-yl)benzoat BCS241005-Ausland STR 80 tert-Butyl-[(3-brompyrazin-2-yl)(cyclopropyl)methyl]carbamat (10.0 g, 30.5 mmol, 1.00 eq), Methyl-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoat (11.9 g, 45.7 mmol, 1.50 eq), K2CO3 (8.42 g, 60.9 mmol, 2.00 eq) und Pd(dppf)Cl2 (2.23 g, 3.05 mmol, 0.100 eq) wurden unter Argon in abs. Dioxan (50.0 mL) und H2O (10.0 mL) gelöst, und das resultierende Reaktionsgemisch wurde bei einer Temperatur von 5 100 °C 12 h lang unter Argon gerührt. Der Reaktionsfortschritt wurde mit LCMS überprüft, und nach vollständigem Umsatz der Startmaterialien wurde das Reaktionsgemisch auf Raumtemperatur abgekühlt, mit EtOAc extrahiert (100 mL x 3), mit wäßriger NaCl-Lösung (100 mL) gewaschen, über Na2SO4 getrocknet, abflitriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbliebenen Rückstandes (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) wurde Methyl-4- 10 (3-{[(tert-butoxycarbonyl)amino](cyclopropyl)methyl}pyrazin-2-yl)benzoat (11.0 g, 94 % der Theorie) in Form eines gelblichen Feststoffes erhalten. Synthesestufe 5: Methyl-4-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoat 15 Methyl-4-(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)-methyl}pyrazin-2-yl)benzoat (4.00 g, 10.4 mmol, 1.00 eq) wurde danach in HCl/Dioxan (4.00 mL) und Dichlormethan (20.0 mL) gelöst und 12 h lang bei Raumtemperatur gerührt. Das Reaktionsgemisch wurde danach unter vermindertem Druck eingeengt und der verbliebene Rückstand aus Ethylacetat (50.0 mL) umkristallisiert. Auf diese Weise wurde Methyl-4-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoat (3.06 g, 91 % der Theorie) in Form 20 eines gelblichen Feststoffs erhalten. Synthesestufe 6: (rac)-Methyl-4-(3-{[3,5-bis(trifluormethyl)benzamido](cyclopropyl)methyl}pyrazin-2- yl)benzoat (I.1-284) 25 Methyl-4-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoat (250 mg, 0.78 mmol, 1.0 eq) wurde unter Argon in einem ausgeheizten Rundkolben in abs. Dichlormethan gelöst und nach 5 Minuten Rühren bei Raumtemperatur mit Triethylamin (0.33 mL, 2.34 mmol, 3.0 eq), 3,5-bis(Trifluormethyl)benzoesäure BCS241005-Ausland STR 81 (202 mg, 0.78 mmol, 1.0 eq) und Propanphosphonsäureanhydrid 50% in THF (0.84 mL, 1.40 mmol, 1.8 eq) versetzt. Das resultierende Reaktionsgemisch wurde 14 h lang bei Raumtemperatur gerührt, danach mit Dichlormethan versetzt und mit verd. HCl (1M) gewaschen. Die organische Phase wurde über Natriumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeengt. Durch 5 säulenchromatographische Reinigung des Rohproduktes (Gradient Heptan/Ethylacetat) wurde Methyl-4- (3-{[3,5-bis(trifluormethyl)benzamido](cyclopropyl)-methyl}pyrazin-2-yl)benzoat (I.1-284) in Form eines farblosen Feststoffs erhalten (350 mg, 83 % der Theorie). 1H NMR (400 MHz, CDCl3): δ (ppm) = 8.65 (d, J = 2.2 Hz, 1H), 8.60 (d, J = 2.2 Hz, 1H), 8.29 (s, 2H), 8.23 (d, J = 8.3 Hz, 2H), 8.03 (s, 1H), 7.84-7.81 (m, 2H), 7.43 (br d, J = 7.9 Hz, 1H), 5.13 (t, J = 8.4 Hz, 1H), 3.98 (s, 3H), 1.22 - 1.13 (m, 1H), 10 0.56-0.49 (m, 1H), 0.40-0.31 (m, 2H), -0.03 - -0.11 (m, 1H). Nr. I.2-48: (rac)-Methyl-3-{3-[1-(3-chlor-5-iodbenzamido)propyl]pyrazin-2-yl}benzoat Synthesestufe 1: 1-(2-Brompyrazin-3-yl)propan-1-ol 15 Eine Lösung von N-Isopropylpropan-2-amin (87.8 g, 868 mmol, 123 mL, 2.30 eq) in abs. Tetrahydrofuran (420 mL) wurde unter Stickstoffatmosphäre auf eine Temperatur von -78 °C eingekühlt und tropfenweise mit einer Lösung von n-Butyllithium in abs. Tetrahydrofuran (2.5 M, 332 mL, 2.20 eq) versetzt. Das resultierende Reaktionsgemisch wurde 30 Minuten lang bei einer Temperatur von -30 °C 20 gerührt, wieder auf -78 °C gekühlt und tropfenweise mit einer Lösung von 2-Brompyrazin (60.0 g, 377 mmol, 1.00 eq) in abs. Tetrahydrofuran (180 mL) versetzt. Das resultierende Reaktionsgemisch wurde anschließend 30 Minuten bei einer Temperatur von -78 °C gerührt, und danach erfolgte die tropfenweise Zugabe von einer Lösung von Propanal (48.2 g, 830 mmol, 60.4 mL, 2.20 eq) in abs. Tetrahydrofuran (60.0 mL) und das Reaktionsgemisch wurde 60 Minuten lang nachgerührt. Nach vollständigem Umsatz25 (Dünnschichtchromatographie und LC-MS-Kontrolle) wurde das reaktionsgemisch mit wäßriger NH4Cl- Lösung (500 mL) versetzt und mehrfach mit EtOAc extrahiert (200 mL x 3). Die vereinigten organischen Phasen wurden mit gesättigter NaCl-Lösung gewaschen (200 mL), über Na2SO4 getrocknet, abfiltriert und unter vermindertem Druck eingeengt. Der verbliebene Rückstand wurde säulenchromatographisch gereinigt (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) und 1-(2- 30 Brompyrazin-3-yl)propan-1-ol (30.0 g, 32.9% der Theorie) wurde in Form eines gelblichen Öls erhalten. BCS241005-Ausland STR 82 Synthesestufe 2: 1-(2-Brompyrazin-3-yl)propan-1-on 1-(2-Brompyrazin-3-yl)propan-1-ol (26.0 g, 120 mmol, 1.00 eq) wurde in abs. Dichlormethan (182 mL) 5 gelöst, mit Pyridiniumchlorochromat (PCC, 52.0 g, 240 mmol, 2.00 eq) versetzt und 12 h lang bei Raumtemperatur gerührt. Nach vollständigem Umsatz (Reaktionskontrolle über Dünnschichtchromatographie) wurde das Reaktionsgemisch abfiltriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbliebenen Rückstandes (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) wurde 1-(2-Brompyrazin-3-yl)propan-1-on (21.0 g, 81.5% der 10 Theorie) in Form eines gelben Feststoffs erhalten.1H-NMR (400 MHz, CDCl3): δ (ppm) = 8.56 - 8.60 (m, 1 H) 8.49 (d, J=2.38 Hz, 1 H) 3.13 (q, J=7.17 Hz, 2 H) 1.25 (t, J=7.25 Hz, 3 H). Synthesestufe 3: tert-Butyl-[1-(3-brompyrazin-2-yl)propyl]carbamat 15 Im nächsten Schritt wurde Ammoniumacetat (96.8 g, 1.26 mol, 15.0 eq) zu einer Lösung von 1-(2- Brompyrazin-3-yl)propan-1-on (18.0 g, 83.7 mmol, 1.00 eq) in abs. MeOH (126 mL) bei Raumtemperatur gegeben. Das resultierende Reaktionsgemisch wurde 2 h lang bei einer Temperatur von 60 °C gerührt, danach mit NaBH3CN (52.6 g, 837 mmol, 10.0 eq) versetzt und 10 h bei einer Temperatur von 60°C weiter gerührt. Nach vollständigem Umsatz (Reaktionskontrolle über LCMS) 20 wurde das Reaktionsgemisch unter vermindertem Druck eingeengt und das in Form eines gelben Feststoffs erhaltene 1-(3-Brompyrazin-2-yl)propan-1-amin (18.0 g, 83.3 mmol, 1.00 eq) wurde ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt und in einem Gemisch aus Tetrahydrofuran (36.0 mL) und H2O (54.0 mL) gelöst. Danach wurden Na2CO3 (26.5 g, 250 mmol, 3.00 eq) und Boc2O (27.3 g, 125 mmol, 28.7 mL, 1.50 eq) zugegeben und das resultierende Reaktionsgemisch 12 h lang bei 25 Raumtemperatur gerührt. Nach vollständigem Umsatz (Reaktionskontrolle mit LCMS) wurde das Reaktionsgemisch gründlich mit EtOAc extrahiert (100 mL x 3), mit wäßriger NaCl-Lösung (100 mL) gewaschen, über Na2SO4 getrocknet, abflitriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbliebenen Rückstandes (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) wurde tert-Butyl-[1-(3-brompyrazin-2-yl)propyl]carbamat (13.0 g, 49.3% der Theorie) in Form 30 eines farblosen Feststoffs erhalten. BCS241005-Ausland STR 83 Stynthesestufe 4: Methyl-3-(3-{1-[(tert-butoxycarbonyl)amino]propyl}pyrazin-2-yl)benzoat tert-Butyl-[1-(3-brompyrazin-2-yl)propyl]carbamat (11.5 g, 36.4 mmol, 1.00 eq), Methyl-3-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)benzoat (14.3 g, 54.6 mmol, 1.50 eq), K2CO3 (10.0 g, 72.7 mmol, 5 2.00 eq) und Pd(dppf)Cl2 (2.66 g, 3.64 mmol, 0.100 eq) wurden unter Argon in abs. Dioxan (57.5 mL) und H2O (11.5 mL) gelöst, und das resultierende Reaktionsgemisch wurde bei einer Temperatur von 100 °C 12 h lang unter Argon gerührt. Der Reaktionsfortschritt wurde mit LCMS überprüft, und nach vollständigem Umsatz der Startmaterialien wurde das Reaktionsgemisch auf Raumtemperatur abgekühlt, mit EtOAc extrahiert (100 mL x 3), mit wäßriger NaCl-Lösung (100 mL) gewaschen, über Na2SO4 10 getrocknet, abflitriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbliebenen Rückstandes (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) wurde Methyl-3- (3-{1-[(tert-butoxycarbonyl)amino]propyl}pyrazin-2-yl)benzoat (12.0 g, 89 % der Theorie) in Form eines gelblichen Feststoffes erhalten. 15 Synthesestufe 5: Methyl-3-[3-(1-aminopropyl)pyrazin-2-yl]benzoat Methyl-3-(3-{1-[(tert-butoxycarbonyl)amino]propyl}pyrazin-2-yl)benzoat (4.00 g, 10.7 mmol, 1.00 eq) wurde danach in HCl/Dioxan (4.00 mL) und Dichlormethan (20.0 mL) gelöst und 12 h lang bei Raumtemperatur gerührt. Das Reaktionsgemisch wurde danach unter vermindertem Druck eingeengt 20 und der verbliebene Rückstand aus Ethylacetat (50.0 mL) umkristallisiert. Auf diese Weise wurde Methyl-3-[3-(1-aminopropyl)pyrazin-2-yl]benzoat (3.04 g, 92 % der Theorie) in Form eines gelblichen Feststoffs erhalten.1H-NMR (400 MHz, CDCl3): δ (ppm) = 8.83 (q, J=2.36 Hz, 2 H) 8.74 (br s, 2 H) 8.17 - 8.21 (m, 1 H) 8.13 (dt, J=7.89, 1.25 Hz, 1 H) 7.98 - 8.03 (m, 1 H) 7.71 - 7.78 (m, 1 H) 4.36 (t, J=6.85 Hz, 1 H) 3.87 - 3.93 (m, 3 H) 1.75 - 1.91 (m, 2 H) 0.63 (t, J=7.46 Hz, 3 H). 25 BCS241005-Ausland STR 84 Synthesestufe 6: Nr. I.2-48: (rac)-Methyl-3-{3-[1-(3-chlor-5-iodbenzamido)propyl]pyrazin-2- yl}benzoat Methyl-3-[3-(1-aminopropyl)pyrazin-2-yl]benzoat (300 mg, 0.97 mmol, 1.0 eq) wurde unter Argon in 5 einem ausgeheizten Rundkolben in abs. Acetonitril (10 mL) gelöst und nach 5 Minuten Rühren bei Raumtemperatur mit Triethylamin (0.41 mL, 2.92 mmol, 3.0 eq), 3-Chlor-5-iodbenzoesäure (275 mg, 0.97 mmol, 1.0 eq) und Propanphosphonsäureanhydrid 50% in THF (1.04 mL, 1.75 mmol, 1.8 eq) versetzt. Das resultierende Reaktionsgemisch wurde 6 h lang bei Raumtemperatur gerührt, danach mit Dichlormethan versetzt und mit verd. HCl (1M) gewaschen. Die organische Phase wurde über 10 Natriumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des Rohproduktes (Gradient Heptan/Ethylacetat) wurde Methyl-3- {3-[1-(3-chlor-5-iodbenzamido)propyl]pyrazin-2-yl}benzoat (I.2-48) in Form eines farblosen Feststoffs erhalten (304 mg, 57 % der Theorie).1H-NMR (Peakpicking: 400 MHz, CDCl3): δ= 8.6366 (2.6); 8.6306 (3.3); 8.5933 (3.1); 8.5874 (2.4); 8.3196 (1.6); 8.3157 (2.6); 8.3117 (1.5); 8.1982 (1.4); 8.1787 15 (1.5); 8.0119 (1.9); 8.0084 (3.1); 8.0049 (1.8); 7.9370 (1.2); 7.9177 (1.4); 7.8423 (1.8); 7.8382 (2.8); 7.8341 (1.7); 7.7511 (2.0); 7.7470 (2.8); 7.7429 (1.6); 7.6635 (1.3); 7.6441 (2.4); 7.6249 (1.2); 7.2630 (9.0); 7.1555 (0.9); 7.1341 (0.9); 5.5674 (0.9); 5.5506 (0.9); 5.5315 (0.5); 5.3018 (7.6); 3.9517 (16.0); 2.0476 (0.8); 1.8385 (0.8); 1.8225 (0.8); 1.8045 (0.7); 1.7874 (0.8); 1.7691 (1.1); 1.7510 (0.9); 1.7344 (0.6); 1.5958 (2.0); 1.2607 (1.1); 0.8817 (0.8); 0.7828 (3.0); 0.7643 (6.4); 0.7458 (2.9); -0.0002 (11.2); - 20 0.0083 (0.7) Nr. I.2-98: Methyl-3-(3-{[3-Brom-5-(trifluormethoxy)benzamido](cyclopropyl)methyl}pyrazin-2- yl)benzoat 25 Synthesestufe 1: (3-Brompyrazin-2-yl)(cyclopropyl)methanol Eine Lösung von N-Isopropylpropan-2-amin (58.6 g, 579 mmol, 82 mL, 2.30 eq) in abs. Tetrahydrofuran (280 mL) wurde unter Argonatmosphäre auf eine Temperatur von -78 °C eingekühlt und tropfenweise mit 30 einer Lösung von n-Butyllithium in abs. Tetrahydrofuran (2.5 M, 221 mL, 2.20 eq) versetzt. Das BCS241005-Ausland STR 85 resultierende Reaktionsgemisch wurde 30 Minuten lang bei einer Temperatur von -30 °C gerührt, wieder auf -78 °C gekühlt und tropfenweise mit einer Lösung von 2-Brompyrazin (40.0 g, 252 mmol, 1.00 eq) in abs. Tetrahydrofuran (120 mL) versetzt. Das resultierende Reaktionsgemisch wurde anschließend 30 Minuten bei einer Temperatur von -78 °C gerührt, und danach erfolgte die tropfenweise Zugabe von einer 5 Lösung von Cyclopropancarbaldehyd (35.3 g, 503 mmol, 37.6 mL, 2.20 eq) in abs. Tetrahydrofuran (40.0 mL), und das Reaktionsgemisch wurde 60 Minuten lang bei einer Temperatur von -78 °C nachgerührt. Nach vollständigem Umsatz (Dünnschichtchromatographie und LC-MS-Kontrolle) wurde das Reaktionsgemisch mit wäßriger NH4Cl-Lösung (500 mL) versetzt und mehrfach mit EtOAc extrahiert (200 mL x 3). Die vereinigten organischen Phasen wurden mit gesättigter NaCl-Lösung gewaschen (200 10 mL), über Na2SO4 getrocknet, abfiltriert und unter vermindertem Druck eingeengt. Der verbliebene Rückstand wurde säulenchromatographisch gereinigt (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) und (3-Brompyrazin-2-yl)(cyclopropyl)methanol (45.0 g, 78 % der Theorie) wurde in Form eines gelblichen Öls erhalten. 15 Synthesestufe 2: 3-Brompyrazin-2-yl)(cyclopropyl)methanon (3-Brompyrazin-2-yl)(cyclopropyl)methanol (45.0 g, 196 mmol, 1.00 eq) wurde in abs. Dichlormethan (315 mL) gelöst, mit Pyridiniumchlorochromat (PCC, 84.7 g, 393 mmol, 2.00 eq) versetzt und 12 h lang bei Raumtemperatur gerührt. Nach vollständigem Umsatz (Reaktionskontrolle über 20 Dünnschichtchromatographie) wurde das Reaktionsgemisch abfiltriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbliebenen Rückstandes (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) wurde 3-Brompyrazin-2-yl)(cyclopropyl)methanon (24.0 g, 54 % der Theorie) in Form eines gelben Feststoffs erhalten. 1H-NMR (400 MHz, CDCl3): δ (ppm) = 8.51-8.55 (m, 1H) 8.38-8.42 (m, 1H) 2.76-2.85 (m, 1H), 1.29 (m, 2H), 1.06-1.14 (m, 2H). 25 Synthesestufe 3: tert-Butyl-[(3-brompyrazin-2-yl)(cyclopropyl)methyl]carbamat Im nächsten Schritt wurde Ammoniumacetat (91.7 g, 1.19 mol, 15.0 eq) zu einer Lösung von 3- Brompyrazin-2-yl)(cyclopropyl)methanon (18.0 g, 79.3 mmol, 1.00 eq) in abs. MeOH (126 mL) bei 30 Raumtemperatur gegeben. Das resultierende Reaktionsgemisch wurde 2 h lang bei einer Temperatur von 60 °C gerührt, danach mit NaBH3CN (49.8 g, 793 mmol, 10.0 eq) versetzt und 10 h bei einer Temperatur BCS241005-Ausland STR 86 von 60°C weiter gerührt. Nach vollständigem Umsatz (Reaktionskontrolle über LCMS) wurde das Reaktionsgemisch unter vermindertem Druck eingeengt und das in Form eines gelben Feststoffs erhaltene 1-(3-Brompyrazin-2-yl)-1-cyclopropylmethanamin (18.0 g, 78.9 mmol, 1.00 eq) wurde ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt und in einem Gemisch aus Tetrahydrofuran (36.0 mL) 5 und H2O (54.0 mL) gelöst. Danach wurden Na2CO3 (25.1 g, 237 mmol, 3.00 eq) und Boc2O (25.8 g, 118 mmol, 1.50 eq) zugegeben und das resultierende Reaktionsgemisch 12 h lang bei Raumtemperatur gerührt. Nach vollständigem Umsatz (Reaktionskontrolle mit LCMS) wurde das Reaktionsgemisch gründlich mit EtOAc extrahiert (100 mL x 3), mit wäßriger NaCl-Lösung (100 mL) gewaschen, über Na2SO4 getrocknet, abflitriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des10 verbliebenen Rückstandes (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) wurde tert-Butyl-[(3- brompyrazin-2-yl)(cyclopropyl)methyl]carbamat (11.0 g, 43 % der Theorie) in Form eines farblosen Feststoffs erhalten. Synthesestufe 4: Methyl-3-(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)methyl}pyrazin-2-yl)benzoat 15 tert-Butyl-[(3-brompyrazin-2-yl)(cyclopropyl)methyl]carbamat (10.0 g, 30.5 mmol, 1.00 eq), Methyl-3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoat (11.9 g, 45.7 mmol, 1.50 eq), K2CO3 (8.42 g, 60.9 mmol, 2.00 eq) und Pd(dppf)Cl2 (2.23 g, 3.05 mmol, 0.100 eq) wurden unter Argon in abs. Dioxan (50.0 mL) und H2O (10.0 mL) gelöst, und das resultierende Reaktionsgemisch wurde bei einer Temperatur von 20 100 °C 12 h lang unter Argon gerührt. Der Reaktionsfortschritt wurde mit LCMS überprüft, und nach vollständigem Umsatz der Startmaterialien wurde das Reaktionsgemisch auf Raumtemperatur abgekühlt, mit EtOAc extrahiert (100 mL x 3), mit wäßriger NaCl-Lösung (100 mL) gewaschen, über Na2SO4 getrocknet, abflitriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbliebenen Rückstandes (SiO2, Petrolether/Ethylacetat = 5/1 bis 20/1) wurde Methyl-3- 25 (3-{[(tert-butoxycarbonyl)amino](cyclopropyl)methyl}pyrazin-2-yl)benzoat (10.6 g, 90 % der Theorie) in Form eines gelblichen Feststoffes erhalten. Synthesestufe 5: Methyl-3-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoat BCS241005-Ausland STR 87 Methyl-3-(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)-methyl}pyrazin-2-yl)benzoat (4.00 g, 10.4 mmol, 1.00 eq) wurde danach in HCl/Dioxan (4.00 mL) und Dichlormethan (20.0 mL) gelöst und 12 h lang bei Raumtemperatur gerührt. Das Reaktionsgemisch wurde danach unter vermindertem Druck 5 eingeengt und der verbliebene Rückstand aus Ethylacetat (50.0 mL) umkristallisiert. Auf diese Weise wurde Methyl-4-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoat (2.91 g, 87 % der Theorie) in Form eines farblosen Feststoffs erhalten. Synthesestufe 6: (rac)-Methyl-3-(3-{[3-Brom-5- 10 (trifluormethoxy)benzamido](cyclopropyl)methyl}pyrazin-2-yl)benzoat (I.2-98) Methyl-3-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoat (300 mg, 0.94 mmol, 1.0 eq) wurde unter Argon in einem ausgeheizten Rundkolben in abs. Dichlormethan gelöst und nach 10 Minuten Rühren bei Raumtemperatur mit Triethylamin (0.39 mL, 2.81 mmol, 3.0 eq), 3-Brom-5- 15 (trifluormethoxy)benzoesäure (262 mg, 0.92 mmol, 1.0 eq) und Propanphosphonsäureanhydrid 50% in THF (1.01 mL, 1.69 mmol, 1.8 eq) versetzt. Das resultierende Reaktionsgemisch wurde 12 h lang bei Raumtemperatur gerührt, danach mit Dichlormethan versetzt und mit verd. HCl (1M) gewaschen. Die organische Phase wurde im Anschluß daran über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des Rohproduktes (Gradient20 Heptan/Ethylacetat) wurde Methyl-3-(3-{[3-Brom-5- (trifluormethoxy)benzamido](cyclopropyl)methyl}pyrazin-2-yl)benzoat (I.2-98) in Form eines farblosen Feststoffs erhalten (406 mg, 74 % der Theorie). 1H NMR (400 MHz, CDCl3): δ (ppm) = 8.64-8.63 (d, , 1H), 8.59-6.58 (d, 1H), 8.38 (s, 1H), 8.19-8.17 (d, 1H), 7.98-7.97 (d, 1H), 7.87 (s, 1H), 7.65-7.60 (m, , 2H), 7.53 (s, 1H), 5.13-5.09 (t, 1H), 3.95 (s, 3H), 1.25 - 1.19 (m, 1H), 0.55-0.48 (m, 1H), 0.42-0.30 (m, 25 2H), 0.06 - 0.02 (m, 1H). In Analogie zu den oben angeführten und an entsprechender Stelle rezitierten Herstellungsbeispielen BCS241005-Ausland STR 88 und unter Berücksichtigung der allgemeinen Angaben zur Herstellung von substituierten Arylpyrazinen erhält man die nachfolgend genannten Verbindungen. Wenn in den Tabellen I.1 bis I.3 ein Strukturelement durch eine Strukturformel definiert ist, welches eine gestrichelte Linie enthält, so bedeutet diese gestrichelte Linie, dass an dieser Position die betreffende Gruppe mit dem Rest des 5 Moleküls verbunden ist. Die entsprechende stereochemische Konfiguration am Stereozentrum C-1 (siehe untere Formel I.1) wird durch die Bezeichnungen “Rac” für ein racemisches Gemisch beider Enantiomere, “Ent-1” für das Enantiomer mit der niedrigeren Retentionszeit in der chiralen HPLC- Analytik oder chiralen präparativen SFC und “Ent-2” für das Enantiomer mit der höheren Retentionszeit in der chiralen HPLC-Analytik oder chiralen präparativen SFC gekennzeichnet. In den nachfolgenden10 Tabellen stehen die Bezeichnungen 1-Methyleth-1-yl, 1-Methylethyl, Prop-2-yl für eine iso- Propylgruppe, und die unterschiedlichen Bezeichnungen für die gleiche Gruppe sind fachlich geläufig. Tabelle I.1: Bevorzugte Verbindungen der Formel (I.1) sind die Verbindungen I.1-1 bis I.1-559, worin Q die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle I.1 hat. Die Verbindungen I.1-1 bis 15 I.1-559 der Tabelle I.1 sind somit durch die Bedeutung der jeweiligen Einträge für die Substituenten R1, R7, R17, R18 und R19 der Tabelle I.1 definiert, wobei R2, R5 und R6 für Wasserstoff stehen. Tabelle I.1: 20 BCS241005-Ausland STR 89 BCS241005-Ausland STR 90 BCS241005-Ausland STR 91 BCS241005-Ausland STR 92 BCS241005-Ausland STR 93 BCS241005-Ausland STR 94 BCS241005-Ausland STR 95 BCS241005-Ausland STR 96 BCS241005-Ausland STR 97 BCS241005-Ausland STR 98 BCS241005-Ausland STR 99 BCS241005-Ausland STR 100 BCS241005-Ausland STR 101 BCS241005-Ausland STR 102 BCS241005-Ausland STR 103 Tabelle I.2: Bevorzugte Verbindungen der Formel (I.2) sind die Verbindungen I.2-1 bis I.2-225, worin Q die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle I.2 hat. Die Verbindungen I.2-1 bis I.2-225 der Tabelle I.2 sind somit durch die Bedeutung der jeweiligen Einträge für die Substituenten R1, 5 R7, R18, R19 und R20 der Tabelle I.2 definiert, wobei R2, R5 und R6 für Wasserstoff stehen. Tabelle I.2: BCS241005-Ausland STR 104 BCS241005-Ausland STR 105 BCS241005-Ausland STR 106 BCS241005-Ausland STR 107 BCS241005-Ausland STR 108 BCS241005-Ausland STR 109 Tabelle I.3: Bevorzugte Verbindungen der Formel (I.3) sind die Verbindungen I.3-1 bis I.3-18, worin Q die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle I.3 hat. Die Verbindungen I.3-1 bis I.3-18 der Tabelle I.3 sind somit durch die Bedeutung der jeweiligen Einträge für die Substituenten R1, 5 R7, R17, R18 und R20 der Tabelle 3 definiert, wobei R2, R5 und R6 für Wasserstoff stehen. BCS241005-Ausland STR 110 Tabelle I.3: Spektroskopische Daten von ausgewählten Beispielen aus den oben aufgeführten Tabellen: 5 Die spektroskopischen Daten der im Folgenden aufgeführten Tebellenbeispiele wurden entweder mit Hilfe klassischer 1H-NMR-Interpretation oder über das NMR-Peaklistenverfahren ausgewertet. a) klassische NMR-Interpretation 10 BCS241005-Ausland STR 111 I.1-86: 1H-NMR (400 MHz, d6-DMSO): δ= 8.73 (d,1H); 8.66 (d,1H); 8.64 (d,1H); 8.06 (d,2H); 7.79 (d,2H); 7.32 (dd,1H); 7.29 (d,1H); 7.12 (d,1H); 5.26 (m,1H); 4.35 (t,2H); 3.21 (t,2H); 1.41 (d,3H) I.1-91: 1H-NMR (400 MHz, CDCl3): δ= 8.62 (d,1H); 8.58 (d,1H); 8.21 (d,2H); 7.75 (d,2H); 7.35 5 (dd,1H); 7.30 (d,1H); 7.18 (d,1H); 6.84 (d,1H); 6.02 (s,2H); 5.63 (m,1H); 3.97 (s,3H); 1.39 (d,3H) I.1-92: 1H-NMR (400 MHz, d6-DMSO): δ= 8.68 (d,1H); 8.65 (d,1H); 8.63 (d,1H); 8.06 (d,2H); 7.79 (d,2H); 7.74 (d,1H); 7.52 (dd,1H); 6.89 (d,1H); 5.83 (s,2H); 5.26 (m,1H); 1.42 (d,3H) 10 I.1-93: 1H-NMR (400 MHz, d6-DMSO): δ= 8.67 (d,1H); 8.66 (d,1H); 8.63 (d,1H); 8.07 (dd,2H); 7.80 (dd,2H); 7.42 (dd,1H); 7.37 (d,1H); 6.95 (d,1H); 6.07 (s,2H); 5.27 (m,1H); 1.42 (d,3H) I.1-102: 1H-NMR (600 MHz, d6-DMSO, ppm) 9.17 (bd, 1H), 8.98 (s, 2H), 8.70 (d, 1H), 8.67 (d, 1H), 8.07 (d, 2H), 7.80 (d, 2H), 5.32 (m, 1H), 3.90 (s, 3H), 2.65 (s, 3H), 1.47 (d, 3H). 15 I.1-103: 1H-NMR (600 MHz, d6-DMSO, ppm): δ = 8.65 (m, 1H), 8.67 (d, 1H), 8.64 (d, 1H), 8.07 (d, 2H), 7.81 (d, 2H), 7.56 (d, 2H), 7.33 (m, 1H), 5.28 (m, 1H), 3.90 (s, 3H), 2.26 (s, 3H), 1.44 (d, 3H). I.1-104: 1H-NMR (600 MHz, d6-DMSO, ppm): δ = 8.93 (bd, 1H), 8.75 (d, 1H), 8.71 (d, 1H), 8.46 (d, 20 1H), 8,11 (d, 2H), 7.79 (d, 2H), 7.47 (d, 1H), 7.16 (m, 1H), 5.34 (m, 1H), 3.91 (s, 3H), 1.42 (d, 3H). I.1-105: 1H-NMR (600 MHz, d6-DMSO, ppm): δ = 8.96 (s, 1H), 8.91 (d, 1H), 8.74 (s, 1H), 8.70 (s, 1H), 8.61 (s, 1H), 8.10 (d, 2H), 7.79 (d, 2H), 5.38 (m, 1H), 3.91 (s, 3H), 2.58 (s, 3H), 1.43 (d, 3H). 25 I.1-106: 1H-NMR (400 MHz, CDCl3): δ= 8.68 (d,1H); 8.66 (d,1H); 8.59 (d,1H); 8.44 (d,1H); 8.29 (dd,1H); 8.23 (d,2H); 7.73 (d,2H); 7.53 (d,1H); 5.69 (m,1H); 3.98 (s,3H); 3.48 (s,3H); 3.45 (s,3H); 1.44 (d,3H) I.1-107: 1H-NMR (400 MHz, CDCl3): δ= 8.67 (d,1H); 8.58 (d,1H); 8.24 (d,2H); 7.77 (d,1H); 7.74 30 (d,2H); 7.61 (dd,1H); 7.58 (d,1H); 7.42 (d,1H); 5.67 (m,1H); 5.09 (s,2H); 3.98 (s,3H); 1.41 (d,3H) I.1-108: 1H-NMR (400 MHz, CDCl3): δ= 8.65 (d,1H); 8.59 (d,1H); 8.23 (d,2H); 7.96 (dd,1H); 7.74 (d,2H); 7.66 (dd,1H); 7.59 (ddd,1H); 7.42 (d,1H); 5.67 (m,1H); 5.55 (d,1H); 5.06 (d,1H); 3.98 (s,3H); 1.41 (d,3H) 35 BCS241005-Ausland STR 112 I.1-109: 1H-NMR (400 MHz, d6-DMSO): δ= 9.06 (d,1H); 8.68 (d,1H); 8.66 (d,1H); 8.08 (d,2H); 7.80 (d,2H); 7.79 (d,1H); 7.53 (dd,1H); 7.43 (d,1H); 5.28 (m,1H); 4.79 (m,2H); 3.90 (s,3H); 3.88 (m,2H); 1.45 (d,3H) 5 I.1-110: 1H-NMR (400 MHz, CDCl3): δ= 8.65 (d,1H); 8.60 (d,1H); 8.22 (dd,2H); 8.13 (dd,1H); 8.10 (d,1H); 7.73 (d,2H); 7.39 (d,1H); 7.19 (d,1H); 5.66 (m,1H); 5.12 (s,2H); 3.97 (s,3H); 1.40 (d,3H) I.1-111: 1H-NMR (400 MHz, d6-DMSO): δ= 9.14 (d,1H); 8.67 (d,1H); 8.65 (d,1H); 8.34 (d,1H); 8.08 (d,2H); 7.96 (dd,1H); 7.82 (d,2H); 7.11 (d,1H); 5.29 (m,1H); 4.81 (m,2H); 3.90 (s,3H); 3.89 (m,2H); 10 1.45 (d,3H) I.1-112: 1H-NMR (400 MHz, d6-DMSO): δ= 9.03 (d,1H); 8.68 (d,1H); 8.66 (d,1H); 8.07 (d,2H); 7.79 (d,2H); 7.69 (d,1H); 7.37 (d,1H); 7.35 (s,1H); 5.28 (m,1H); 3.67 (t,2H); 3.58 (t,2H); 1.44 (d,3H) 15 I.1-113: 1H-NMR (400 MHz, d6-DMSO): δ= 8.97 (d,1H); 8.67 (d,1H); 8.64 (d,1H); 8.17 (d,1H); 8.06 (d,2H); 7.97 (dd,1H); 7.80 (d,2H); 7.01 (d,1H); 5.28 (m,1H); 3.67 (t,2H); 3.59 (t,2H); 1.43 (d,3H) I.1-114: 1H-NMR (400 MHz, CDCl3): δ= 8.68 (d,1H); 8.61 (d,1H); 8.37 (d,1H); 8.36 (dd,1H); 8.23 (d,2H); 8.08 (d,1H); 7.72 (d,2H); 7.58 (d,1H); 5.68 (m,1H); 4.76 (s,2H); 3.98 (s,3H); 1.43 (d,3H) 20 I.1-130: 1H-NMR (400 MHz, CDCl3): δ= 8.67 (d,1H); 8.60 (d,1H); 8.36 (d,1H); 8.27 (dd,1H); 8.23 (d,2H); 8.10 (d,1H); 7.72 (d,2H); 7.51 (d,1H); 5.68 (m,1H); 4.11 (s,4H); 3.98 (s,3H); 1.42 (d,3H) I.1-141: 1H-NMR (400 MHz, CDCl3): δ= 8.71 (d,1H); 8.60 (d,1H); 8.48 (d,1H); 8.32 (dd,1H); 8.25 25 (d,2H); 8.08 (d,1H); 8.06 (d,1H); 7.75 (d,2H); 5.66 (m,1H); 4.12 (s,4H); 1.48 (d,3H) I.1-162: 1H-NMR (400 MHz, d6-DMSO ^, ppm) 9.68 (d, 2H), 8.06 (d, 2H), 7.82 (d, 2H), 7.71 (s, 1H), 7.68 (s, 1H), 7.45 (s, 1H), 5.45 (s, 1H), 5.35 (m, 1H), 3.89 (s, 1H), 1.84-1.82 (m, 2H), 1.74-1.71 (m, 2H), 1.43 (d, 3H). 30 I.1-172: 1H-NMR (400 MHz, CDCl3): δ= 8.73 (s,1H); 8.67 (d,1H); 8.62 (d,1H); 8.48 (s,2H); 8.31 (t,1H); 8.25 (d,2H); 8.19 (d,1H); 7.76 (d,2H); 7.51 (d,1H); 5.70 (m,1H); 3.98 (s,3H); 3.17 (s,3H); 1.46 (d,3H) I.1-173: 1H-NMR (400 MHz, d6-DMSO): δ= 9.02 (d,1H); 8.68 (d,1H); 8.66 (d,1H); 8.39 (d,1H); 8.08 35 (d,2H); 8.07 (d,1H); 7.82 (d,2H); 7.81 (dd,1H); 5.36 (m,1H); 2.83 (s,3H); 1.47 (d,3H) BCS241005-Ausland STR 113 I.1-184: 1H-NMR (400 MHz, d6-DMSO): δ= 9.12 (d,1H); 8.68 (d,1H); 8.66 (d,1H); 8.50 (m,1H); 8.18- 7.9 (m,6H); 7.82 (d,2H); 7.51 (m,1H); 5.38 (m,1H); 1.49 (d,3H) I.1-186: 1H-NMR (400 MHz, d6-DMSO): δ= 9.48 (d,1H); 8.72 (d,1H); 8.70 (d,1H); 8.68 (d,1H); 8.54 5 (t,1H); 8.47 (t,1H); 8.26 (t,1H); 8.07 (d,2H); 7.87 (d,1H); 7.82 (d,2H); 6.64 (dd,1H); 5.38 (m,1H); 3.32 (s,3H); 1.51 (d,3H) I.1-229: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.72 (bd, 1H), 8.67 (s, 1H), 8.64 (s, 1H), 8.08 (d, 2H), 8.05 (s, 1H), 7.80 (d, 2H), 7.50 (s, 1H), 5.24 (m, 1H), 3.91 (s, 3H), 1.42 (d, 3H). 10 I.1-230: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.74 (bd, 1H), 8.70 (s, 1H), 8.68 (s, 1H), 8.10 (d, 2H), 7.78 (d, 2H), 7.30 (s, 1H), 5.23 (m, 1H), 3.91 (s, 3H), 1.43 (d, 3H). I.1-232: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.72 (bd, 1H), 8.69 (s, 1H), 8.68 (s, 1H), 8.08 (d, 15 2H), 7.73 (d, 2H), 7.30 (s, 1H), 5.23 (m, 1H), 1.41 (d, 3H), 1.28 (t, 3H). I.1-239: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.84 (bd, 1H), 8.72 (d, 1H), 8.70 (d, 1H), 8.11 (d, 2H), 7.79 (d, 2H), 5.30 (m, 1H), 3.91 (s, 3H), 3.74 (s, 3H), 3.31 (s, 3H), 1.42 (d, 3H). 20 I.1-241: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.77-8.69 (m, 3H), 8.10 (d, 1H), 7.78 (d, 2H), 7.59 (s, 1H), 5.29 (m, 1H), 3.90 (s, 3H), 2.43 (s, 3H), 1.43 (d, 3H). I.1-250: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.77 (d, 1H), 8.74 (d, 1H), 8.38 (d, 1H), 8.12 (d, 2H), 7.95 (d, 2H), 5.33 (m, 1H), 3.95 (s, 3H), 3.91 (s, 3H), 1.39 (d, 3H). 25 I.2-2: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.96 (bd, 1H), 8.15-8.13 (m, 2H), 8.11 (m, 1H), 8.03 (m, 1H), 7.98 (m, 1H), 7.73 (m, 1H), 7.67-7.63 (m, 2H), 7.48 (m, 1H), 7.42 (m, 1H), 5.31 (m, 1H), 1.77- 1.74 (m, 2H), 1.56-1.53 (m, 2H), 1.48 (d, 3H). 30 I.2-156: 1H NMR (400 MHz, CDCl3): δ (ppm) = 8.64-8.63 (d, , 1H), 8.59-6.58 (d, 1H), 8.37 (s, 1H), 8.19- 8.17 (d, 1H), 7.99-7.97 (d, 1H), 7.87 (s, 1H), 7.65-7.60 (m, 2H), 7.53 (s, 1H), 5.13-5.09 (t, 1H), 3.95 (s, 3H), 1.25 - 1.19 (m, 1H), 0.55-0.48 (m, 1H), 0.42-0.30 (m, 2H), 0.06 - 0.02 (m, 1H). I.2-157: 1H NMR (400 MHz, CDCl3): δ (ppm) = 8.64-8.63 (d, , 1H), 8.59-6.58 (d, 1H), 8.38 (s, 1H), 8.20- 35 8.18 (d, 1H), 7.98-7.96 (d, 1H), 7.88 (s, 1H), 7.65-7.60 (m, , 2H), 7.52 (s, 1H), 5.13-5.09 (t, 1H), 3.95 (s, 3H), 1.25 - 1.19 (m, 1H), 0.55-0.48 (m, 1H), 0.42-0.30 (m, 2H), 0.06 - 0.02 (m, 1H). BCS241005-Ausland STR 114 b) NMR-Peak-Listenverfahren Die 1H-NMR-Daten ausgewählter Beispiele können auch in Form von 1H-NMR-Peaklisten notiert werden. Zu jedem Signalpeak wird erst der ^-Wert in ppm und dann die Signalintensität in runden 5 Klammern aufgeführt. Die ^^Wert – Signalintensitäts- Zahlenpaare von verschiedenen Signalpeaks werden durch Semikolons voneinander getrennt aufgelistet. Die Peakliste eines Beispiels hat daher die Form: ^1 (Intensität1 ); ^2 (Intensität2);……..; ^i (Intensitäti );……; ^n (Intensitätn) 10 Die Intensität scharfer Signale korreliert mit der Höhe der Signale in einem gedruckten Beispiel eines NMR-Spektrums in cm und zeigt die wirklichen Verhältnisse der Signalintensitäten. Bei breiten Signalen können mehrere Peaks oder die Mitte des Signals und ihre relative Intensität im Vergleich zum intensivsten Signal im Spektrum gezeigt werden. Zur Kalibrierung der chemischen Verschiebung von 15 1H-NMR-Spektren benutzen wir Tetramethylsilan und/oder die chemische Verschiebung des Lösungsmittels, besonders im Falle von Spektren, die in DMSO gemessen werden. Daher kann in NMR- Peaklisten der Tetramethylsilan-Peak vorkommen, muss es aber nicht. Die Listen der 1H-NMR-Peaks sind ähnlich den klassischen 1H-NMR-Ausdrucken und enthalten somit gewöhnlich alle Peaks, die bei einer klassischen NMR-Interpretation aufgeführt werden. Darüber hinaus können sie wie klassische 1H- 20 NMR-Ausdrucke Lösungsmittelsignale, Signale von Stereoisomeren der Zielverbindun-gen, die ebenfalls Gegenstand der Erfindung sind, und/oder Peaks von Verunreinigungen zeigen. Bei der Angabe von Verbindungssignalen im Delta-Bereich von Lösungsmitteln und/oder Wasser sind in unseren Listen von 1H-NMR-Peaks die gewöhnlichen Lösungsmittelpeaks, zum Beispiel Peaks von DMSO in DMSO- D6 und der Peak von Wasser, gezeigt, die gewöhnlich im Durchschnitt eine hohe Intensität aufweisen. 25 Die Peaks von Stereoisomeren der Zielverbindungen und/oder Peaks von Verunreinigungen haben gewöhnlich im Durchschnitt eine geringere Intensität als die Peaks der Zielverbindungen (zum Beispiel mit einer Reinheit von >90%). Solche Stereoisomere und/oder Verunreinigungen können typisch für das jeweilige Herstellungsverfahren sein. Ihre Peaks können somit dabei helfen, die Reproduktion unseres Herstellungsverfahrens anhand von “Nebenprodukt- 30 Fingerabdrücken” zu erkennen. Einem Experten, der die Peaks der Zielverbindungen mit bekannten Verfahren (MestreC, ACD-Simulation, aber auch mit empirisch ausgewerteten Erwartungswerten) berechnet, kann je nach Bedarf die Peaks der Zielverbindungen isolieren, wobei gegebenenfalls zusätzliche Intensitätsfilter eingesetzt werden. Diese Isolierung wäre ähnlich dem betreffenden Peak- Picking bei der klassischen 1H-NMR-Interpretation. Weitere Details zu 1H-NMR-Peaklisten können der 35 Research Disclosure Database Nummer 564025 entnommen werden. Beispiel Nr.: BCS241005-Ausland STR 115 I.1-1: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6688 (2.5); 8.6627 (3.1); 8.6111 (2.3); 8.6049 (2.0); 8.2496 (2.9); 8.2455 (4.8); 8.2406 (1.1); 8.2289 (1.0); 8.2240 (3.4); 8.0194 (1.1); 7.7490 (3.2); 7.7441 (1.0); 7.7324 (0.9); 7.7276 (3.0); 7.2609 (26.9); 5.7125 (0.5); 5.6956 (0.6); 5.6764 (0.6); 3.9778 (16.0); 1.5657 (0.7); 1.4524 (4.6); 1.4356 (4.7); 1.2553 (1.8); 0.0080 (1.1); 0.0022 (1.5); -0.0002 (37.4); -0.0026 (1.7); - 0.0042 (0.7); -0.0084 (1.1) I.1-2: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4468 (2.8); 9.4303 (3.0); 8.6580 (3.9); 8.6519 (14.0); 8.6480 (16.0); 8.6419 (4.8); 8.4821 (9.8); 8.2856 (4.5); 8.0102 (7.5); 7.9897 (8.8); 7.6739 (7.2); 7.6534 (6.6); 5.4230 (1.9); 5.4061 (3.0); 5.3891 (1.9); 3.3313 (5.2); 2.6805 (0.5); 2.6759 (1.2); 2.6712 (1.7); 2.6667 (1.2); 2.5418 (4.9); 2.5369 (0.9); 2.5323 (1.1); 2.5250 (4.9); 2.5203 (6.4); 2.5116 (95.7); 2.5071 (209.6); 2.5024 (292.9); 2.4979 (200.8); 2.4933 (88.0); 2.3341 (1.3); 2.3295 (1.7); 2.3248 (1.2); 2.3203 (0.5); 1.4922 (11.3); 1.4750 (11.3); 0.1458 (0.7); 0.0295 (0.6); 0.0080 (6.5); -0.0002 (230.9); -0.0085 (6.2); -0.1494 (0.7) I.1-3: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6681 (2.4); 8.6621 (2.9); 8.6115 (2.2); 8.6054 (1.8); 8.2494 (2.9); 8.2480 (2.8); 8.2453 (4.8); 8.2404 (1.2); 8.2287 (1.0); 8.2238 (3.3); 8.2197 (0.5); 8.1223 (0.5); 8.0192 (1.1); 7.7488 (3.1); 7.7439 (1.0); 7.7322 (0.9); 7.7273 (2.9); 7.7060 (0.5); 7.2611 (22.8); 5.7126 (0.5); 5.6956 (0.6); 5.6935 (0.6); 5.6765 (0.6); 3.9778 (16.0); 3.9533 (2.6); 1.5782 (1.7); 1.4520 (4.5); 1.4353 (4.5); 0.0079 (0.8); -0.0002 (30.1); -0.0085 (0.9) I.1-4: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6680 (1.8); 8.6619 (2.2); 8.6116 (1.9); 8.6055 (1.6); 8.2492 (2.9); 8.2449 (3.8); 8.2400 (1.1); 8.2282 (1.0); 8.2234 (3.3); 8.2192 (0.6); 8.0181 (1.2); 7.7498 (3.0); 7.7449 (1.0); 7.7332 (0.9); 7.7283 (2.9); 7.2624 (10.8); 5.7123 (0.5); 5.6953 (0.6); 5.6932 (0.6); 5.6761 (0.5); 3.9776 (16.0); 2.9581 (1.2); 2.9574 (1.2); 2.8851 (1.1); 2.8837 (1.1); 2.8043 (5.2); 1.4526 (4.5); 1.4358 (4.5); 1.4327 (1.2); 1.2915 (0.6); 1.2743 (0.6); -0.0002 (13.1) I.1-5: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6583 (2.5); 8.6523 (3.2); 8.6071 (2.6); 8.6011 (2.2); 8.2421 (0.5); 8.2380 (3.2); 8.2332 (1.2); 8.2214 (1.2); 8.2166 (3.5); 8.2125 (0.8); 7.9645 (1.8); 7.9606 (1.3); 7.9375 (1.8); 7.9359 (1.7); 7.7463 (2.0); 7.7419 (4.3); 7.7371 (1.4); 7.7252 (1.1); 7.7205 (3.2); 7.7164 (0.7); 7.3751 (0.6); 7.3559 (0.6); 7.2613 (14.2); 5.6860 (0.7); 5.6689 (0.8); 5.6498 (0.7); 3.9756 (16.0); 1.5699 (6.2); 1.4295 (5.3); 1.4128 (5.3); -0.0002 (15.4); -0.0084 (0.7) I.1-6: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2710 (3.2); 9.2545 (3.3); 8.6929 (7.7); 8.6868 (12.1); 8.6681 (13.8); 8.6620 (9.4); 8.1429 (5.8); 8.1391 (3.9); 8.0867 (5.5); 8.0851 (5.6); 8.0670 (1.7); 8.0627 (10.9); 8.0580 (3.6); 8.0463 (3.9); 8.0414 (16.0); 8.0369 (6.8); 7.7909 (1.9); 7.7868 (12.0); 7.7820 (3.8); 7.7703 (3.4); 7.7655 (10.5); 7.7613 (1.6); 5.3529 (2.1); 5.3359 (3.3); 5.3190 (2.2); 4.0570 (0.6); 4.0392 BCS241005-Ausland STR 116 (1.9); 4.0214 (1.9); 4.0036 (0.6); 3.8920 (1.0); 3.3837 (1.9); 2.6771 (0.5); 2.6726 (0.7); 2.6680 (0.5); 2.5431 (0.6); 2.5264 (2.0); 2.5217 (2.7); 2.5130 (39.7); 2.5084 (88.9); 2.5038 (125.6); 2.4992 (87.6); 2.4946 (39.3); 2.3355 (0.5); 2.3308 (0.7); 2.3262 (0.5); 1.9901 (8.9); 1.9108 (6.8); 1.4941 (12.6); 1.4769 (12.6); 1.3565 (1.7); 1.1934 (2.6); 1.1756 (5.3); 1.1578 (2.6); 0.0080 (2.6); 0.0064 (0.7); 0.0056 (0.7); 0.0047 (0.9); -0.0002 (86.2); -0.0050 (1.0); -0.0058 (0.8); -0.0067 (0.7); -0.0085 (2.4) I.1-7: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6670 (2.6); 8.6610 (3.2); 8.6114 (2.6); 8.6053 (2.1); 8.2449 (5.7); 8.2402 (1.4); 8.2284 (1.0); 8.2235 (3.5); 8.2193 (0.6); 8.0190 (1.4); 7.7482 (3.2); 7.7433 (1.2); 7.7317 (1.0); 7.7269 (3.1); 7.7226 (0.6); 7.4505 (0.5); 7.4311 (0.5); 7.2612 (14.8); 5.7124 (0.6); 5.6954 (0.7); 5.6933 (0.7); 5.6762 (0.6); 3.9777 (16.0); 2.8034 (1.8); 1.5696 (5.5); 1.4510 (5.0); 1.4343 (5.0); 0.0080 (0.5); -0.0002 (20.6); -0.0085 (0.6) I.1-8: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7156 (7.9); 8.7095 (9.5); 8.6357 (7.3); 8.6295 (6.4); 8.3037 (16.0); 8.2872 (2.8); 8.2823 (9.3); 8.2782 (1.6); 8.0231 (3.6); 7.8194 (1.8); 7.8079 (1.9); 7.8038 (9.8); 7.7990 (4.4); 7.7873 (2.8); 7.7825 (8.4); 7.7783 (1.3); 7.2643 (0.8); 7.2610 (47.9); 7.2570 (0.6); 5.7676 (1.5); 5.7488 (1.9); 5.7314 (1.6); 3.7575 (1.1); 1.8594 (1.3); 1.5268 (11.4); 1.5100 (11.5); 1.4324 (1.9); 1.2547 (0.8); 1.2424 (1.8); 1.2228 (0.9); 0.0080 (1.9); 0.0039 (0.6); 0.0030 (1.3); 0.0023 (2.2); -0.0002 (68.7); -0.0027 (3.1); -0.0034 (2.1); -0.0043 (1.2); -0.0051 (0.9); -0.0059 (0.8); -0.0067 (0.7); -0.0084 (2.0) I.1-9: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6914 (0.6); 8.6854 (0.7); 8.6707 (0.5); 8.6300 (0.7); 8.6238 (0.6); 8.2954 (0.7); 8.2744 (0.8); 7.7962 (0.8); 7.7752 (0.8); 7.6670 (0.6); 7.2606 (14.8); 5.3000 (16.0); 4.1322 (0.7); 4.1143 (0.8); 2.0469 (3.3); 1.4960 (1.2); 1.4792 (1.2); 1.3332 (0.8); 1.2841 (1.2); 1.2779 (1.5); 1.2599 (4.4); 1.2550 (4.8); 1.2423 (1.8); 0.8802 (0.7); -0.0002 (17.5); -0.0084 (0.9) I.1-10: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4284 (4.2); 9.4118 (4.4); 8.7014 (8.9); 8.6953 (14.2); 8.6771 (15.1); 8.6710 (10.1); 8.4528 (0.5); 8.4354 (14.8); 8.2820 (6.6); 8.0560 (12.5); 8.0516 (4.2); 8.0395 (4.6); 8.0349 (15.3); 7.7911 (14.4); 7.7866 (4.6); 7.7745 (4.3); 7.7700 (12.5); 5.4131 (0.5); 5.3963 (2.7); 5.3794 (4.2); 5.3624 (2.7); 5.3453 (0.6); 3.5955 (0.9); 2.6747 (0.7); 2.5452 (1.0); 2.5284 (2.1); 2.5237 (3.0); 2.5150 (43.9); 2.5104 (93.8); 2.5059 (129.5); 2.5013 (90.2); 2.4968 (40.5); 2.3376 (0.6); 2.3330 (0.7); 2.3282 (0.5); 1.5215 (16.0); 1.5043 (15.9); 0.0079 (1.9); -0.0002 (62.4); -0.0085 (1.8) I.1-11: 1H-NMR(400.6 MHz, CDCl3): δ= 8.8751 (5.7); 8.7310 (5.5); 8.7250 (6.6); 8.6359 (6.5); 8.6298 (9.4); 8.4925 (5.8); 8.3132 (6.0); 8.2928 (7.0); 8.0085 (2.5); 7.9891 (2.7); 7.8053 (6.2); 7.7850 (6.1); 7.2615 (42.5); 5.7614 (1.6); 5.7438 (2.4); 5.7259 (1.8); 5.7082 (0.6); 5.2999 (16.0); 2.3926 (0.8); 2.3737 (0.5); 2.1429 (0.8); 2.0618 (0.7); 2.0480 (1.6); 1.6158 (0.6); 1.6016 (0.6); 1.5421 (9.7); 1.5253 (10.2); 1.5033 (1.1); 1.3337 (1.7); 1.3148 (1.0); 1.2846 (3.1); 1.2782 (2.7); 1.2753 (3.0); 1.2582 (14.5); 1.2428 BCS241005-Ausland STR 117 (2.0); 0.9413 (0.9); 0.9245 (0.9); 0.8964 (1.4); 0.8816 (3.6); 0.8637 (1.8); 0.8364 (0.5); 0.0707 (6.3); 0.0080 (1.1); -0.0002 (48.8); -0.0085 (2.3) I.1-12: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6466 (2.5); 8.6406 (3.2); 8.5971 (2.9); 8.5910 (2.3); 8.2370 (3.2); 8.2325 (1.2); 8.2203 (1.4); 8.2160 (3.7); 8.0722 (1.8); 8.0053 (1.0); 7.9858 (1.1); 7.7803 (0.9); 7.7578 (4.4); 7.7532 (1.5); 7.7410 (1.4); 7.7367 (3.4); 7.6071 (0.8); 7.5877 (1.4); 7.5684 (0.6); 7.3835 (0.6); 7.3636 (0.6); 7.2612 (13.0); 5.7126 (0.8); 5.6956 (0.9); 5.6763 (0.8); 3.9740 (16.0); 1.5701 (2.0); 1.4330 (5.8); 1.4163 (5.8); 0.0079 (0.6); -0.0002 (14.0); -0.0084 (0.6) I.1-13: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6548 (2.6); 8.6487 (3.4); 8.6031 (3.0); 8.5970 (2.5); 8.2455 (3.4); 8.2407 (1.6); 8.2336 (2.4); 8.2293 (2.5); 8.2245 (4.1); 8.1723 (3.4); 8.1678 (1.3); 8.1557 (1.2); 8.1511 (4.0); 8.0360 (1.9); 7.9864 (1.9); 7.7687 (3.6); 7.7641 (1.4); 7.7521 (1.2); 7.7476 (3.5); 7.7132 (3.7); 7.7086 (1.3); 7.6965 (1.2); 7.6920 (3.5); 7.4179 (0.8); 7.3989 (0.9); 7.2606 (34.7); 5.7345 (0.7); 5.7154 (0.9); 5.6983 (0.8); 3.9759 (16.0); 3.9642 (15.9); 1.5536 (11.0); 1.4584 (5.4); 1.4416 (5.5); 0.0080 (1.1); -0.0002 (37.5); -0.0084 (1.8) I.1-14: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6591 (2.5); 8.6531 (3.1); 8.6041 (2.5); 8.5981 (2.1); 8.2382 (3.0); 8.2334 (1.0); 8.2217 (1.0); 8.2169 (3.4); 8.2126 (0.5); 7.8470 (1.5); 7.7422 (3.3); 7.7373 (1.1); 7.7308 (0.6); 7.7256 (1.6); 7.7209 (3.4); 7.7166 (0.6); 7.7047 (0.6); 7.4860 (0.6); 7.4659 (0.6); 7.2608 (19.5); 5.6906 (0.6); 5.6737 (0.7); 5.6544 (0.6); 3.9758 (16.0); 1.5641 (1.2); 1.4281 (5.1); 1.4114 (5.1); 0.8820 (0.6); 0.0080 (0.8); -0.0002 (28.6); -0.0085 (0.8) I.1-15: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6636 (2.6); 8.6576 (3.2); 8.6077 (2.5); 8.6016 (2.1); 8.2385 (3.0); 8.2338 (1.0); 8.2220 (1.0); 8.2172 (3.4); 8.2130 (0.6); 8.1187 (1.6); 8.1150 (1.0); 7.9858 (1.6); 7.9842 (1.6); 7.8958 (1.4); 7.8945 (1.4); 7.7458 (3.3); 7.7410 (1.1); 7.7292 (0.9); 7.7244 (3.1); 7.7202 (0.6); 7.3859 (0.5); 7.2616 (9.2); 5.6837 (0.6); 5.6666 (0.7); 5.6645 (0.7); 5.6474 (0.6); 3.9751 (16.0); 1.4354 (5.1); 1.4186 (5.0); 0.8818 (0.6); -0.0002 (13.4) I.1-16: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6521 (2.6); 8.6460 (3.1); 8.5901 (2.5); 8.5841 (2.1); 8.2352 (3.0); 8.2305 (1.0); 8.2188 (1.0); 8.2139 (3.4); 8.2098 (0.6); 8.1397 (1.4); 8.1345 (1.5); 7.9247 (0.8); 7.9197 (0.7); 7.9040 (0.8); 7.8989 (0.8); 7.7448 (3.2); 7.7400 (1.2); 7.7282 (1.0); 7.7235 (3.1); 7.7192 (0.7); 7.6051 (1.4); 7.5844 (1.2); 7.3572 (0.5); 7.2611 (13.6); 5.6909 (0.6); 5.6716 (0.7); 5.6546 (0.6); 3.9739 (16.0); 1.5773 (0.6); 1.4221 (5.2); 1.4053 (5.1); 0.8818 (0.9); 0.0079 (0.5); -0.0002 (19.8); -0.0085 (0.7) I.1-17: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6586 (2.5); 8.6525 (3.1); 8.5945 (2.4); 8.5884 (2.1); 8.2370 (3.0); 8.2322 (1.0); 8.2205 (1.0); 8.2156 (3.4); 8.2114 (0.6); 7.9369 (1.8); 7.7760 (5.4); 7.7735 (5.5); BCS241005-Ausland STR 118 7.7407 (3.3); 7.7358 (1.1); 7.7241 (1.0); 7.7193 (3.0); 7.7150 (0.6); 7.2605 (29.0); 5.6861 (0.6); 5.6691 (0.7); 5.6498 (0.6); 3.9759 (16.0); 1.5525 (0.9); 1.4209 (5.0); 1.4042 (5.0); 0.0080 (1.1); -0.0002 (42.5); - 0.0085 (1.3) I.1-18: 1H-NMR(400.6 MHz, CDCl3): δ= 9.2077 (0.6); 9.2028 (0.6); 9.0112 (0.5); 9.0078 (0.5); 8.6695 (0.9); 8.6634 (1.1); 8.6025 (0.9); 8.5965 (0.8); 8.3826 (0.6); 8.2443 (1.1); 8.2233 (1.2); 7.7423 (1.2); 7.7213 (1.1); 7.2617 (6.4); 3.9787 (5.4); 2.8085 (16.0); 1.4432 (1.9); 1.4265 (1.9); -0.0002 (9.0) I.1-19: 1H-NMR(400.6 MHz, CDCl3): δ= 8.8844 (1.4); 8.8720 (1.4); 8.6731 (2.6); 8.6671 (3.0); 8.6018 (2.6); 8.5958 (2.2); 8.2476 (0.5); 8.2433 (3.2); 8.2386 (1.1); 8.2268 (1.1); 8.2221 (3.6); 8.2179 (0.6); 8.0443 (1.9); 7.8626 (1.0); 7.8592 (1.0); 7.8502 (1.0); 7.8469 (1.0); 7.7370 (0.6); 7.7328 (3.5); 7.7280 (1.2); 7.7163 (1.1); 7.7116 (3.3); 7.7073 (0.5); 7.5647 (0.5); 7.5448 (0.5); 7.2621 (11.9); 5.7050 (0.7); 5.6878 (0.8); 5.6689 (0.7); 3.9792 (16.0); 1.5822 (2.4); 1.4350 (5.5); 1.4183 (5.5); -0.0002 (12.3) I.1-20: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2424 (1.0); 9.2259 (1.0); 8.6905 (2.4); 8.6843 (3.8); 8.6662 (4.3); 8.6602 (2.9); 8.0619 (3.4); 8.0573 (1.1); 8.0455 (1.2); 8.0407 (4.1); 8.0366 (0.7); 8.0226 (1.8); 7.9333 (0.7); 7.9096 (0.7); 7.8833 (0.7); 7.8621 (0.7); 7.7931 (0.6); 7.7891 (3.8); 7.7843 (1.2); 7.7725 (1.1); 7.7678 (3.3); 7.7636 (0.5); 5.3526 (0.7); 5.3357 (1.0); 5.3188 (0.7); 3.3218 (16.0); 2.5251 (1.0); 2.5204 (1.4); 2.5116 (20.1); 2.5071 (44.9); 2.5025 (63.3); 2.4979 (44.3); 2.4933 (19.9); 1.9096 (0.6); 1.4929 (4.1); 1.4756 (4.1); 1.2466 (0.9); 0.8579 (1.8); 0.8403 (0.6); 0.0079 (1.1); -0.0002 (40.3); - 0.0085 (1.2) I.1-21: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2730 (1.3); 9.2565 (1.3); 8.6917 (3.0); 8.6856 (4.7); 8.6671 (5.3); 8.6609 (3.6); 8.2836 (2.3); 8.1405 (2.1); 8.1390 (2.1); 8.1158 (2.2); 8.1143 (2.1); 8.0668 (0.6); 8.0626 (4.1); 8.0580 (1.4); 8.0462 (1.4); 8.0414 (5.0); 8.0373 (0.8); 7.7903 (0.7); 7.7863 (4.6); 7.7815 (1.4); 7.7697 (1.3); 7.7650 (4.1); 7.7608 (0.6); 5.7578 (0.7); 5.3486 (0.8); 5.3318 (1.3); 5.3148 (0.8); 3.3220 (16.0); 2.5253 (1.1); 2.5207 (1.4); 2.5119 (23.4); 2.5073 (52.7); 2.5027 (74.5); 2.4981 (52.4); 2.4936 (23.7); 1.9895 (0.8); 1.9098 (1.0); 1.4907 (4.9); 1.4735 (4.9); 1.2464 (2.0); 0.8747 (1.0); 0.8578 (4.2); 0.8402 (1.4); 0.0080 (1.3); -0.0002 (49.6); -0.0085 (1.5) I.1-22: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2498 (1.2); 9.2333 (1.2); 8.6860 (2.8); 8.6798 (4.5); 8.6631 (5.1); 8.6570 (3.4); 8.2180 (1.8); 8.2128 (2.0); 8.1043 (1.0); 8.0994 (0.9); 8.0836 (1.2); 8.0786 (1.1); 8.0656 (0.6); 8.0613 (3.9); 8.0566 (1.3); 8.0449 (1.3); 8.0400 (4.8); 8.0359 (0.7); 7.8185 (1.9); 7.7974 (1.8); 7.7900 (4.5); 7.7852 (1.4); 7.7735 (1.2); 7.7688 (3.8); 7.7646 (0.6); 5.3490 (0.8); 5.3321 (1.2); 5.3151 (0.8); 4.0388 (0.6); 4.0210 (0.6); 3.3234 (16.0); 2.5257 (0.8); 2.5210 (1.1); 2.5123 (18.6); 2.5077 (42.1); 2.5031 (59.8); 2.4985 (42.0); 2.4939 (19.0); 1.9896 (2.6); 1.9102 (1.2); 1.4838 (4.8); BCS241005-Ausland STR 119 1.4666 (4.8); 1.2585 (0.8); 1.2461 (2.1); 1.1931 (0.8); 1.1753 (1.6); 1.1575 (0.8); 0.8746 (1.1); 0.8577 (4.4); 0.8401 (1.5); 0.0080 (1.1); -0.0002 (41.0); -0.0085 (1.2) I.1-23: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1034 (0.6); 9.2401 (1.2); 9.2236 (1.2); 8.6906 (2.8); 8.6844 (4.6); 8.6672 (5.3); 8.6611 (3.5); 8.0826 (2.4); 8.0716 (4.1); 8.0669 (1.3); 8.0552 (1.4); 8.0503 (5.0); 8.0462 (0.8); 7.9263 (4.1); 7.9199 (2.3); 7.7958 (0.7); 7.7917 (4.6); 7.7869 (1.4); 7.7752 (1.3); 7.7704 (4.0); 7.7663 (0.6); 5.3376 (0.8); 5.3207 (1.2); 5.3037 (0.8); 3.3235 (16.0); 2.5256 (0.9); 2.5209 (1.2); 2.5122 (18.7); 2.5076 (42.1); 2.5030 (59.5); 2.4984 (41.5); 2.4938 (18.5); 1.4832 (4.8); 1.4659 (4.8); 1.2463 (1.3); 0.8746 (0.6); 0.8578 (2.7); 0.8401 (0.9); 0.0080 (1.1); -0.0002 (41.4); -0.0050 (0.6); - 0.0085 (1.2) I.1-24: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3486 (1.6); 9.3321 (1.7); 9.1805 (2.7); 9.1756 (2.8); 9.1015 (2.1); 9.0993 (2.4); 9.0963 (2.4); 9.0945 (2.1); 8.7023 (4.0); 8.6961 (6.2); 8.6769 (7.1); 8.6708 (4.8); 8.5239 (1.6); 8.5203 (2.6); 8.5188 (2.5); 8.5151 (1.5); 8.0696 (0.8); 8.0653 (5.6); 8.0607 (1.8); 8.0489 (1.9); 8.0441 (6.7); 8.0400 (1.0); 7.7993 (1.0); 7.7951 (6.3); 7.7903 (1.9); 7.7786 (1.7); 7.7738 (5.4); 7.7697 (0.8); 5.3818 (1.1); 5.3648 (1.8); 5.3478 (1.1); 3.3272 (16.0); 2.6903 (11.5); 2.5261 (1.1); 2.5214 (1.5); 2.5126 (21.2); 2.5081 (47.4); 2.5035 (66.9); 2.4989 (46.8); 2.4943 (20.9); 1.9898 (0.8); 1.9104 (1.8); 1.5078 (6.8); 1.4906 (6.8); 1.2463 (1.0); 0.8745 (0.5); 0.8577 (2.0); 0.8401 (0.7); 0.0080 (1.2); -0.0002 (43.7); -0.0085 (1.2) I.1-25: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6984 (0.7); 8.6923 (1.2); 8.6761 (1.3); 8.6700 (0.8); 8.1844 (0.6); 8.0615 (1.0); 8.0403 (1.2); 7.7837 (1.1); 7.7625 (1.0); 5.7571 (0.6); 3.3195 (16.0); 2.5241 (0.7); 2.5194 (1.0); 2.5106 (15.8); 2.5061 (35.2); 2.5014 (49.7); 2.4969 (34.9); 2.4923 (15.7); 1.9888 (0.8); 1.5041 (1.2); 1.4869 (1.2); 1.3552 (1.0); 0.0080 (1.0); -0.0002 (34.0); -0.0085 (1.0) I.1-26: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6596 (2.5); 8.6535 (3.1); 8.6074 (2.5); 8.6014 (2.0); 8.2384 (3.1); 8.2336 (1.0); 8.2219 (1.0); 8.2170 (3.3); 8.2128 (0.5); 7.9654 (1.5); 7.9614 (1.0); 7.9402 (1.2); 7.9384 (1.5); 7.9367 (1.4); 7.7467 (1.6); 7.7422 (3.9); 7.7373 (1.0); 7.7256 (1.0); 7.7208 (3.0); 7.2611 (16.7); 5.6859 (0.6); 5.6689 (0.7); 5.6497 (0.6); 3.9757 (16.0); 3.9534 (0.7); 1.5875 (0.7); 1.4304 (5.0); 1.4136 (5.0); 0.0080 (0.7); -0.0002 (23.7); -0.0085 (0.6) I.1-27: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6197 (6.0); 8.2200 (1.6); 8.1986 (1.7); 8.1283 (1.4); 8.1250 (1.5); 8.0086 (1.3); 8.0055 (1.3); 7.7349 (1.5); 7.7135 (1.5); 7.5187 (1.7); 7.2989 (0.6); 7.2710 (0.5); 7.2603 (287.6); 7.2330 (1.0); 7.2267 (0.8); 6.9967 (1.7); 4.0972 (1.5); 3.9757 (1.3); 3.9670 (8.0); 3.9618 (1.6); 3.9507 (0.8); 3.4546 (0.5); 2.3575 (1.4); 2.2936 (0.6); 1.6303 (1.9); 1.4803 (1.0); 1.4417 (2.8); 1.4250 (2.9); 1.3328 (2.0); 1.2842 (3.5); 1.2542 (16.0); 1.2325 (4.1); 0.8801 (2.5); 0.8527 (1.7); 0.8352 BCS241005-Ausland STR 120 (1.3); 0.2383 (0.6); 0.1583 (0.9); 0.1455 (1.4); 0.0686 (0.6); 0.0386 (0.5); 0.0295 (0.6); 0.0080 (9.9); - 0.0002 (428.8); -0.0085 (14.1); -0.0274 (1.7); -0.0339 (1.3); -0.0454 (0.8); -0.1493 (1.3) I.1-28: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7805 (1.4); 8.7789 (1.5); 8.7742 (1.5); 8.7726 (1.5); 8.6557 (2.6); 8.6496 (3.1); 8.5825 (2.4); 8.5764 (2.1); 8.2337 (3.0); 8.2289 (1.0); 8.2172 (1.0); 8.2124 (3.3); 8.2082 (0.5); 7.9904 (1.4); 7.9840 (1.4); 7.9697 (1.5); 7.9634 (1.5); 7.7367 (3.2); 7.7319 (1.0); 7.7202 (0.9); 7.7154 (2.9); 7.5937 (1.8); 7.5920 (1.8); 7.5731 (1.6); 7.5714 (1.6); 7.2611 (22.8); 5.6892 (0.6); 5.6722 (0.7); 5.6530 (0.6); 3.9740 (16.0); 2.0455 (0.9); 1.5798 (1.2); 1.4172 (5.0); 1.4005 (5.0); 1.2597 (0.8); 0.8819 (0.8); 0.0080 (0.9); -0.0002 (32.8); -0.0085 (0.9) I.1-29: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2710 (1.3); 9.2546 (1.4); 8.6927 (3.2); 8.6866 (5.1); 8.6680 (5.7); 8.6619 (3.9); 8.1428 (2.4); 8.1389 (1.6); 8.0865 (2.4); 8.0850 (2.4); 8.0667 (0.7); 8.0625 (4.6); 8.0579 (1.5); 8.0461 (1.7); 8.0413 (6.8); 8.0369 (2.9); 7.7905 (0.8); 7.7864 (5.0); 7.7816 (1.6); 7.7699 (1.4); 7.7652 (4.4); 7.7610 (0.7); 5.7582 (1.1); 5.3527 (0.9); 5.3358 (1.4); 5.3189 (0.9); 4.0391 (0.6); 4.0214 (0.7); 3.3257 (16.0); 2.5263 (1.0); 2.5217 (1.3); 2.5129 (17.8); 2.5084 (39.6); 2.5037 (55.9); 2.4992 (39.0); 2.4946 (17.4); 1.9900 (3.0); 1.9108 (1.1); 1.4941 (5.4); 1.4769 (5.3); 1.3565 (2.5); 1.2330 (0.5); 1.1934 (1.0); 1.1820 (1.8); 1.1756 (2.1); 1.1702 (0.6); 1.1579 (0.9); 0.0080 (0.7); -0.0002 (22.6); - 0.0085 (0.6) I.1-30: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7299 (0.8); 8.7282 (0.9); 8.7236 (0.9); 8.7218 (0.9); 8.6873 (1.0); 8.6811 (1.6); 8.6630 (1.9); 8.6569 (1.2); 8.0895 (0.7); 8.0832 (0.7); 8.0689 (1.8); 8.0651 (0.6); 8.0624 (0.9); 8.0485 (1.8); 7.7927 (1.6); 7.7880 (0.5); 7.7715 (1.4); 7.7466 (0.9); 7.7450 (0.9); 7.7258 (0.8); 7.7242 (0.9); 5.7570 (3.1); 4.0379 (0.9); 4.0202 (0.9); 3.3206 (16.0); 2.5243 (0.8); 2.5196 (1.0); 2.5108 (14.4); 2.5063 (32.2); 2.5016 (45.4); 2.4971 (31.6); 2.4925 (14.1); 1.9888 (4.3); 1.9088 (1.0); 1.4694 (1.7); 1.4522 (1.7); 1.3552 (0.5); 1.1923 (1.2); 1.1809 (0.7); 1.1746 (2.5); 1.1568 (1.2); - 0.0002 (17.6) I.1-31: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6755 (2.4); 8.6694 (2.8); 8.5967 (2.3); 8.5906 (2.0); 8.2385 (3.0); 8.2336 (1.0); 8.2220 (1.0); 8.2171 (3.3); 8.2129 (0.5); 7.7183 (3.2); 7.7134 (1.0); 7.7017 (0.9); 7.6969 (3.0); 7.2624 (7.6); 7.1943 (5.4); 5.6679 (0.6); 5.6509 (0.7); 5.6488 (0.7); 5.6319 (0.6); 3.9786 (16.0); 1.4111 (5.1); 1.3944 (5.1); 1.2550 (0.8); -0.0002 (11.8) I.1-32: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6792 (0.9); 8.6732 (1.1); 8.6608 (2.1); 8.6547 (2.6); 8.6075 (2.4); 8.6014 (2.0); 8.5946 (1.0); 8.5885 (0.9); 8.3039 (1.6); 8.2377 (2.5); 8.2331 (0.9); 8.2220 (1.7); 8.2168 (3.0); 8.2123 (0.5); 8.2018 (1.3); 8.0780 (1.3); 8.0069 (1.3); 7.7452 (2.8); 7.7405 (0.9); 7.7287 (0.9); 7.7241 (2.6); 7.6623 (1.4); 7.6576 (0.5); 7.6413 (1.2); 7.2610 (19.8); 5.6776 (0.6); 5.6605 (0.6); BCS241005-Ausland STR 121 5.6412 (0.6); 3.9744 (16.0); 2.0459 (1.4); 1.4336 (4.3); 1.4169 (4.3); 1.3749 (2.3); 1.3582 (2.3); 1.2598 (0.9); 0.0079 (0.8); -0.0002 (26.0); -0.0085 (0.8) I.1-33: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6513 (2.5); 8.6452 (3.2); 8.6028 (2.6); 8.5967 (2.0); 8.2319 (3.1); 8.2271 (1.0); 8.2154 (1.0); 8.2106 (3.3); 8.2063 (0.5); 7.7394 (0.5); 7.7352 (3.4); 7.7304 (1.0); 7.7186 (1.0); 7.7138 (3.0); 7.6717 (6.1); 7.6670 (6.4); 7.4993 (1.6); 7.4946 (2.9); 7.4898 (1.4); 7.2605 (32.6); 5.6605 (0.6); 5.6436 (0.7); 5.6242 (0.6); 5.3001 (1.1); 3.9737 (16.0); 1.5529 (3.1); 1.4093 (5.1); 1.3926 (5.1); 0.0079 (1.4); -0.0002 (51.1); -0.0085 (1.4) I.1-34: 1H-NMR(400.6 MHz, CDCl3): δ= 8.8155 (1.0); 8.8112 (1.7); 8.8069 (1.0); 8.6794 (2.6); 8.6733 (3.1); 8.6260 (1.5); 8.6222 (1.0); 8.6176 (2.7); 8.6115 (2.1); 8.4428 (1.6); 8.4414 (1.6); 8.2504 (0.5); 8.2461 (3.2); 8.2413 (1.0); 8.2296 (1.1); 8.2247 (3.5); 8.2206 (0.5); 7.7498 (0.6); 7.7456 (3.4); 7.7408 (1.1); 7.7291 (1.0); 7.7243 (3.1); 7.5995 (0.6); 7.5802 (0.6); 7.2649 (5.2); 5.7190 (0.6); 5.7017 (0.8); 5.6830 (0.6); 5.3006 (10.6); 3.9802 (16.0); 1.6642 (0.6); 1.4618 (5.1); 1.4451 (5.0); -0.0002 (5.9) I.1-35: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6892 (0.7); 8.6671 (0.8); 8.6610 (0.6); 8.0712 (0.6); 8.0499 (0.8); 7.7976 (0.7); 7.7762 (0.7); 3.8920 (2.9); 3.3192 (16.0); 2.5194 (0.6); 2.5106 (8.8); 2.5060 (19.6); 2.5014 (27.9); 2.4968 (19.6); 2.4922 (9.0); 1.4818 (0.8); 1.4646 (0.8); 0.0079 (0.8); -0.0002 (29.7); -0.0044 (0.5); -0.0085 (0.9) I.1-36: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1836 (0.7); 9.1672 (0.8); 8.6881 (1.7); 8.6820 (2.8); 8.6639 (3.2); 8.6578 (2.2); 8.0628 (2.5); 8.0581 (0.8); 8.0464 (0.9); 8.0416 (3.0); 7.9491 (1.2); 7.9449 (1.7); 7.9409 (1.3); 7.7816 (2.7); 7.7768 (0.9); 7.7651 (0.8); 7.7604 (2.5); 7.7549 (0.7); 7.7524 (0.7); 7.7490 (1.1); 7.7447 (0.8); 7.7425 (0.7); 7.7151 (1.1); 7.7122 (1.2); 7.7096 (0.9); 5.3129 (0.8); 3.3216 (16.0); 2.5248 (1.0); 2.5201 (1.3); 2.5113 (18.9); 2.5068 (41.9); 2.5022 (58.9); 2.4976 (41.2); 2.4930 (18.8); 1.9891 (0.9); 1.4783 (2.9); 1.4611 (2.9); 1.3556 (1.2); 1.1749 (0.6); 0.0080 (1.4); -0.0002 (47.9); - 0.0085 (1.4) I.1-37: 1H-NMR(400.6 MHz, CDCl3): δ= 8.8179 (0.9); 8.8135 (1.5); 8.8093 (0.9); 8.6789 (2.3); 8.6728 (2.8); 8.6265 (1.3); 8.6227 (0.9); 8.6159 (2.4); 8.6099 (2.0); 8.4442 (1.4); 8.4429 (1.4); 8.2465 (3.0); 8.2416 (1.0); 8.2300 (1.0); 8.2251 (3.3); 8.2209 (0.6); 7.7495 (0.5); 7.7453 (3.2); 7.7405 (1.0); 7.7288 (1.0); 7.7240 (2.9); 7.7198 (0.5); 7.2647 (5.2); 5.7203 (0.6); 5.7031 (0.7); 5.7015 (0.7); 5.6843 (0.6); 5.3007 (5.7); 3.9803 (16.0); 1.6563 (0.6); 1.4619 (4.7); 1.4451 (4.7); -0.0002 (6.8) I.1-38: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6681 (2.5); 8.6620 (3.0); 8.6076 (2.5); 8.6015 (2.1); 8.5083 (1.8); 8.3789 (1.6); 8.3406 (1.5); 8.3392 (1.6); 8.2452 (2.9); 8.2405 (1.0); 8.2287 (1.0); 8.2239 (3.5); 8.2198 (0.5); 7.7493 (0.5); 7.7451 (3.2); 7.7403 (1.0); 7.7285 (0.9); 7.7238 (3.2); 7.4964 (0.6); 7.4773 BCS241005-Ausland STR 122 (0.6); 7.2620 (20.1); 5.7106 (0.6); 5.6919 (0.8); 5.6747 (0.6); 4.1486 (1.1); 4.1308 (3.4); 4.1130 (3.4); 4.0951 (1.1); 3.9786 (15.1); 3.1441 (14.4); 2.0455 (16.0); 1.5789 (11.7); 1.4554 (4.9); 1.4386 (4.8); 1.2774 (4.4); 1.2596 (8.8); 1.2418 (4.2); 0.0079 (0.7); -0.0002 (22.3); -0.0085 (0.6) I.1-39: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6586 (2.5); 8.6525 (3.0); 8.6011 (2.4); 8.5950 (2.0); 8.2368 (3.0); 8.2320 (1.0); 8.2203 (1.0); 8.2154 (3.3); 7.7378 (3.2); 7.7330 (1.0); 7.7213 (0.9); 7.7165 (2.9); 7.6043 (2.4); 7.5990 (2.4); 7.2613 (16.3); 7.2469 (0.9); 7.2447 (1.0); 7.2424 (0.9); 5.6786 (0.6); 5.6616 (0.7); 5.6425 (0.6); 3.9751 (16.0); 1.5710 (7.7); 1.4210 (4.8); 1.4042 (4.8); -0.0002 (18.4); -0.0085 (0.5) I.1-40: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6579 (0.7); 8.6518 (0.8); 8.6044 (0.6); 8.5984 (0.5); 8.2388 (0.8); 8.2173 (0.9); 7.7450 (0.9); 7.7236 (0.8); 7.2604 (24.9); 6.6042 (0.7); 3.9755 (4.4); 1.5443 (16.0); 1.4333 (1.2); 1.4166 (1.2); 0.0080 (0.8); -0.0002 (28.6); -0.0085 (0.8) I.1-41: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6656 (0.9); 8.6595 (1.1); 8.6107 (0.9); 8.6046 (0.7); 8.2481 (1.1); 8.2247 (1.1); 8.2033 (1.2); 7.7448 (1.2); 7.7235 (1.0); 7.2607 (20.3); 4.6543 (1.1); 4.6385 (0.5); 4.2259 (1.4); 4.2080 (1.4); 2.8377 (0.6); 2.8219 (1.4); 2.8060 (0.6); 1.5514 (16.0); 1.4486 (1.6); 1.4319 (1.6); 1.3082 (1.7); 1.2904 (3.6); 1.2725 (1.9); 1.2657 (0.6); 0.8820 (1.1); 0.0080 (0.7); -0.0002 (22.6); - 0.0085 (0.7) I.1-43: 1H-NMR(400.6 MHz, CDCl3): δ= 9.2204 (3.5); 9.2162 (3.7); 9.2081 (3.6); 9.2039 (3.6); 8.6754 (8.2); 8.6693 (10.3); 8.6230 (8.7); 8.6169 (7.0); 8.3082 (10.0); 8.3035 (3.6); 8.2916 (3.7); 8.2868 (11.2); 8.2473 (11.3); 8.0206 (5.0); 7.7853 (10.7); 7.7806 (3.8); 7.7687 (3.5); 7.7640 (10.1); 7.7156 (3.2); 7.7114 (3.3); 7.6944 (4.4); 7.6902 (4.4); 7.5812 (4.7); 7.5688 (4.7); 7.5601 (3.6); 7.5477 (3.5); 7.5204 (0.5); 7.4713 (2.0); 7.4522 (2.1); 7.2620 (82.0); 5.8201 (0.8); 5.7861 (11.7); 5.7813 (11.8); 5.7471 (0.8); 5.7223 (0.6); 5.7057 (2.1); 5.6867 (2.6); 5.6695 (2.1); 5.6528 (0.6); 5.3005 (15.1); 4.1490 (0.5); 4.1311 (1.7); 4.1132 (1.7); 4.0954 (0.6); 2.1802 (0.5); 2.1325 (2.4); 2.1042 (1.8); 2.0458 (8.4); 1.5832 (10.8); 1.4609 (16.0); 1.4442 (16.0); 1.4242 (1.4); 1.3333 (0.7); 1.2845 (1.2); 1.2776 (2.7); 1.2597 (6.0); 1.2419 (2.4); 0.8802 (0.6); 0.0079 (3.0); -0.0002 (87.8); -0.0085 (2.9) I.1-44: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6851 (6.5); 8.6791 (8.9); 8.6256 (7.3); 8.6194 (7.2); 8.2802 (8.9); 8.2591 (9.9); 7.9074 (6.4); 7.7977 (5.4); 7.7828 (10.2); 7.7616 (9.5); 7.5540 (2.6); 7.5342 (8.0); 7.2626 (78.6); 7.2605 (183.6); 6.9969 (1.2); 6.7972 (3.5); 6.6165 (7.1); 6.4358 (3.5); 5.7356 (2.1); 5.7162 (2.9); 5.6994 (2.3); 2.1271 (1.6); 1.4847 (15.6); 1.4680 (16.0); 1.4322 (3.3); 1.2561 (4.0); 0.1458 (1.0); 0.0079 (3.8); 0.0020 (87.7); -0.0002 (209.3); -0.1489 (1.4) BCS241005-Ausland STR 123 I.1-45: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6850 (8.1); 8.6789 (10.1); 8.6223 (8.7); 8.6162 (7.5); 8.2793 (9.8); 8.2582 (11.0); 7.7752 (10.5); 7.7585 (3.4); 7.7541 (9.7); 7.6315 (9.4); 7.6264 (9.7); 7.5190 (2.5); 7.5030 (2.5); 7.2915 (0.5); 7.2604 (210.9); 6.9968 (1.2); 5.7366 (0.6); 5.7197 (2.0); 5.7017 (2.7); 5.6837 (2.2); 5.6665 (0.6); 4.1496 (0.8); 4.1317 (2.1); 4.1140 (2.2); 4.0961 (0.6); 2.1289 (1.9); 2.0464 (9.6); 1.4700 (16.0); 1.4532 (15.9); 1.2843 (1.2); 1.2779 (3.3); 1.2600 (8.3); 1.2422 (3.4); 0.8803 (1.0); 0.1458 (0.8); 0.0307 (0.7); 0.0148 (0.8); 0.0078 (7.1); -0.0002 (234.7); -0.0085 (8.2); -0.0284 (0.8); -0.1494 (0.9) I.1-46: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7002 (2.8); 8.6941 (3.5); 8.6281 (2.9); 8.6219 (2.5); 8.5479 (2.1); 8.4075 (1.8); 8.3464 (1.8); 8.2973 (3.2); 8.2927 (1.1); 8.2808 (1.1); 8.2761 (3.8); 7.7918 (3.4); 7.7873 (1.2); 7.7707 (3.4); 7.7070 (0.8); 7.6873 (0.9); 7.2607 (68.4); 5.7465 (0.7); 5.7277 (0.8); 5.7100 (0.6); 5.3003 (2.6); 3.1472 (16.0); 2.1307 (1.6); 2.0465 (1.4); 1.5112 (5.0); 1.4944 (5.1); 1.2844 (0.6); 1.2779 (0.7); 1.2599 (2.2); 1.2560 (2.2); 1.2422 (0.7); 0.0080 (2.2); -0.0002 (78.6); -0.0085 (2.5) I.1-47: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6714 (0.6); 8.2739 (0.5); 8.2525 (0.7); 8.2454 (0.5); 7.8147 (0.6); 7.7932 (0.5); 7.2606 (21.8); 5.0259 (1.9); 3.8280 (0.5); 3.7585 (1.4); 3.7425 (1.4); 1.5463 (16.0); 1.4656 (0.8); 1.4488 (0.8); 0.0079 (0.7); -0.0002 (23.5); -0.0085 (0.6) I.1-48: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3019 (0.6); 9.2854 (0.6); 8.7048 (1.5); 8.6987 (2.2); 8.6734 (2.6); 8.6673 (1.9); 8.2542 (1.0); 8.2504 (2.0); 8.2465 (1.2); 8.1621 (1.0); 8.1573 (1.5); 8.1534 (1.1); 8.1120 (1.3); 8.1077 (1.6); 8.1030 (1.0); 8.0844 (2.1); 8.0797 (0.6); 8.0680 (0.7); 8.0630 (2.5); 7.8126 (2.4); 7.8077 (0.7); 7.7960 (0.7); 7.7912 (2.1); 5.7573 (2.6); 5.3277 (0.6); 3.8966 (9.2); 3.3198 (16.0); 3.3095 (8.5); 3.2505 (0.5); 2.5243 (0.8); 2.5196 (1.2); 2.5109 (15.6); 2.5063 (33.7); 2.5017 (47.0); 2.4971 (31.9); 2.4926 (13.7); 1.9888 (1.9); 1.4992 (2.4); 1.4819 (2.3); 1.1924 (0.5); 1.1746 (1.0); 0.0081 (1.3); -0.0002 (49.1); -0.0085 (1.3) I.1-49: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4275 (2.5); 9.4109 (2.5); 8.7003 (5.8); 8.6942 (9.2); 8.6760 (10.4); 8.6699 (6.8); 8.4522 (0.7); 8.4343 (8.5); 8.2817 (3.8); 8.0586 (1.2); 8.0545 (8.2); 8.0498 (2.6); 8.0380 (2.9); 8.0332 (9.8); 8.0291 (1.4); 7.7938 (1.5); 7.7897 (9.3); 7.7850 (2.8); 7.7732 (2.7); 7.7685 (8.0); 7.7643 (1.2); 7.6295 (0.8); 7.6265 (0.5); 7.6177 (0.5); 7.6005 (0.6); 7.5680 (0.6); 5.3945 (1.6); 5.3775 (2.5); 5.3605 (1.6); 4.0395 (1.0); 4.0217 (1.0); 2.9979 (1.2); 2.6731 (0.6); 2.5436 (0.8); 2.5269 (1.5); 2.5222 (2.1); 2.5135 (35.2); 2.5089 (77.7); 2.5043 (108.6); 2.4997 (74.5); 2.4952 (32.8); 2.3314 (0.6); 1.9947 (1.3); 1.9902 (4.6); 1.9110 (16.0); 1.5201 (9.8); 1.5029 (9.7); 1.2592 (0.7); 1.2329 (2.9); 1.1938 (1.7); 1.1760 (3.2); 1.1582 (1.5); 0.8855 (0.6); 0.8773 (0.8); 0.8720 (0.6); 0.8587 (0.5); 0.8530 (0.7); 0.0079 (2.7); 0.0062 (0.7); 0.0053 (0.9); 0.0045 (1.2); -0.0002 (102.2); -0.0052 (1.3); - 0.0060 (1.1); -0.0069 (1.0); -0.0085 (3.0) BCS241005-Ausland STR 124 I.1-50: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6961 (6.5); 8.6900 (7.6); 8.6162 (6.6); 8.6101 (5.7); 8.3084 (0.7); 8.2923 (14.5); 8.2757 (3.0); 8.2710 (7.6); 8.0155 (4.0); 7.7810 (7.9); 7.7761 (4.0); 7.7644 (3.0); 7.7598 (7.7); 7.7553 (3.2); 7.7178 (1.4); 7.7135 (8.9); 7.7103 (11.9); 7.7067 (5.1); 7.6982 (3.6); 7.6931 (16.0); 7.6894 (13.6); 7.6834 (9.1); 7.6801 (11.7); 7.6766 (5.1); 7.6681 (3.6); 7.6629 (15.7); 7.6593 (13.3); 7.5800 (1.5); 7.5764 (3.5); 7.5727 (3.5); 7.5691 (1.7); 7.5640 (2.1); 7.5583 (7.4); 7.5540 (7.4); 7.5486 (2.6); 7.5430 (4.2); 7.5394 (9.1); 7.5356 (8.4); 7.5319 (3.1); 7.4955 (8.0); 7.4938 (10.5); 7.4906 (7.0); 7.4882 (8.7); 7.4865 (10.5); 7.4831 (4.8); 7.4783 (8.6); 7.4749 (15.0); 7.4709 (11.5); 7.4675 (14.4); 7.4636 (4.1); 7.4610 (3.0); 7.4572 (6.6); 7.4541 (5.0); 7.4498 (6.2); 7.4470 (3.7); 7.2617 (58.6); 7.2573 (0.8); 7.2566 (0.8); 7.2550 (0.6); 6.2770 (1.0); 6.2629 (1.0); 5.7464 (1.4); 5.7290 (1.8); 5.7105 (1.5); 2.1115 (8.1); 2.0471 (0.5); 1.6441 (0.9); 1.6272 (0.9); 1.5988 (0.7); 1.5960 (0.7); 1.5847 (0.7); 1.5820 (0.7); 1.5011 (10.6); 1.4843 (10.8); 1.4615 (0.7); 1.4208 (4.6); 1.4066 (4.7); 1.3341 (2.9); 1.2846 (4.4); 1.2777 (1.5); 1.2560 (7.2); 1.2373 (1.3); 1.2332 (0.9); 1.1803 (1.2); 1.1644 (1.2); 1.0010 (0.5); 0.9826 (0.6); 0.8968 (0.8); 0.8802 (2.0); 0.8626 (0.9); 0.0080 (1.8); -0.0002 (66.2); -0.0085 (1.9) I.1-51: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3193 (0.7); 9.3029 (0.7); 8.6974 (1.7); 8.6913 (2.5); 8.6700 (3.0); 8.6640 (2.1); 8.2756 (1.2); 8.2717 (2.3); 8.2678 (1.3); 8.1849 (1.2); 8.1801 (1.6); 8.1762 (1.2); 8.1119 (1.4); 8.1077 (1.8); 8.1030 (1.2); 8.0725 (2.3); 8.0678 (0.7); 8.0560 (0.8); 8.0512 (2.8); 7.7956 (2.5); 7.7908 (0.8); 7.7791 (0.7); 7.7743 (2.2); 5.3309 (0.7); 3.3422 (16.0); 3.3113 (9.8); 2.6703 (0.6); 2.5408 (0.8); 2.5240 (1.4); 2.5194 (2.1); 2.5106 (30.0); 2.5061 (65.4); 2.5015 (91.5); 2.4968 (62.5); 2.4923 (27.0); 2.3285 (0.5); 1.4953 (2.6); 1.4781 (2.6); 0.0080 (1.5); -0.0002 (58.0); -0.0028 (1.9); - 0.0044 (0.6); -0.0085 (1.6) I.1-52: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6871 (0.6); 8.6810 (1.0); 8.6606 (1.2); 8.6545 (0.8); 8.0846 (0.9); 8.0632 (1.1); 7.8242 (1.0); 7.8028 (0.9); 7.5688 (0.5); 3.8939 (4.1); 3.3219 (16.0); 2.5113 (6.1); 2.5067 (13.5); 2.5021 (19.0); 2.4975 (13.1); 2.4929 (5.7); 1.4718 (1.1); 1.4546 (1.1); -0.0002 (8.6) I.1-53: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9710 (0.8); 8.9668 (0.7); 8.7051 (0.7); 8.6990 (1.1); 8.6766 (1.3); 8.6705 (0.9); 8.0791 (1.0); 8.0577 (1.3); 7.8137 (1.2); 7.7923 (1.0); 3.8913 (4.7); 3.3220 (16.0); 2.5201 (0.6); 2.5114 (6.9); 2.5068 (14.7); 2.5023 (20.3); 2.4976 (13.9); 2.4931 (6.0); 1.9892 (1.1); 1.4981 (1.3); 1.4809 (1.2); 1.1749 (0.6); -0.0002 (8.9) I.1-54: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6794 (0.9); 8.6733 (1.5); 8.6568 (1.8); 8.6507 (1.1); 8.0708 (1.3); 8.0495 (1.6); 7.8500 (0.5); 7.8025 (1.5); 7.7812 (1.3); 7.5732 (0.8); 7.5541 (0.6); 3.3226 (16.0); 2.5244 (0.7); 2.5197 (1.0); 2.5110 (14.9); 2.5064 (32.9); 2.5018 (46.2); 2.4972 (31.6); 2.4926 (13.7); 1.9888 (2.4); 1.4688 (1.6); 1.4516 (1.6); 1.1924 (0.7); 1.1746 (1.5); 1.1568 (0.7); 0.0080 (1.4); - 0.0002 (50.4); -0.0029 (1.2); -0.0085 (1.3) BCS241005-Ausland STR 125 I.1-55: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2846 (0.7); 9.2680 (0.7); 8.9804 (1.7); 8.9762 (1.7); 8.8089 (0.9); 8.8023 (0.9); 8.6977 (1.6); 8.6916 (2.6); 8.6730 (3.0); 8.6669 (2.0); 8.1721 (0.5); 8.1696 (0.7); 8.1676 (0.8); 8.1653 (1.0); 8.1630 (0.8); 8.1610 (0.6); 8.0645 (2.3); 8.0598 (0.7); 8.0481 (0.8); 8.0432 (2.8); 7.7912 (2.6); 7.7864 (0.8); 7.7747 (0.7); 7.7699 (2.2); 5.3468 (0.7); 3.3221 (16.0); 2.5247 (1.0); 2.5201 (1.4); 2.5113 (18.6); 2.5068 (40.4); 2.5022 (56.4); 2.4976 (38.5); 2.4930 (16.5); 2.1234 (1.0); 1.9891 (2.1); 1.9093 (0.6); 1.4956 (2.7); 1.4784 (2.7); 1.1926 (0.6); 1.1749 (1.2); 1.1571 (0.6); 0.0080 (2.0); 0.0066 (0.6); 0.0057 (0.6); 0.0048 (0.8); -0.0002 (71.2); -0.0085 (1.8) I.1-56: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6866 (8.8); 8.6805 (10.5); 8.6217 (8.6); 8.6157 (7.1); 8.3725 (1.6); 8.2859 (9.7); 8.2812 (3.2); 8.2693 (3.3); 8.2646 (11.1); 8.2256 (1.5); 8.1137 (4.0); 8.1093 (5.7); 8.1052 (4.2); 7.9821 (1.1); 7.9774 (2.2); 7.9352 (5.6); 7.8909 (5.0); 7.8861 (8.1); 7.8813 (3.9); 7.7813 (10.3); 7.7765 (3.2); 7.7600 (9.7); 7.5190 (3.1); 7.5011 (2.0); 7.4806 (2.2); 7.3102 (0.8); 7.2989 (0.8); 7.2900 (1.0); 7.2836 (1.0); 7.2605 (528.8); 7.2572 (11.0); 7.2548 (3.2); 7.2539 (2.9); 7.2532 (2.3); 7.2523 (2.0); 7.2515 (1.8); 7.2492 (1.4); 7.2476 (1.2); 7.2350 (1.2); 7.2292 (1.3); 6.9968 (3.0); 5.7070 (1.9); 5.6882 (2.4); 5.6712 (2.0); 1.6119 (1.8); 1.4717 (16.0); 1.4550 (15.8); 1.3329 (4.2); 1.2842 (5.7); 1.2563 (3.7); 1.1410 (1.5); 1.1254 (1.6); 0.8803 (1.1); 0.1458 (1.8); 0.0382 (0.8); 0.0295 (1.2); 0.0137 (0.9); 0.0121 (1.2); 0.0113 (1.3); 0.0105 (1.8); 0.0096 (2.6); 0.0080 (17.0); 0.0057 (6.6); 0.0049 (8.5); 0.0041 (11.0); -0.0002 (612.8); -0.0057 (6.3); -0.0066 (6.0); -0.0085 (16.8); -0.0129 (2.4); -0.0153 (1.6); -0.0185 (1.2); -0.0217 (1.1); -0.0256 (1.7); -0.0317 (1.5); -0.0502 (0.8); -0.1497 (1.7) I.1-57: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6675 (2.0); 8.6614 (2.5); 8.6101 (2.0); 8.6040 (1.7); 8.2735 (2.4); 8.2687 (0.8); 8.2521 (4.8); 8.0189 (1.0); 7.7500 (2.5); 7.7452 (0.8); 7.7335 (0.8); 7.7287 (2.3); 7.2616 (14.1); 5.6957 (0.6); 5.3002 (3.1); 4.5454 (0.9); 4.5434 (1.0); 4.5357 (1.1); 4.5342 (1.1); 4.5313 (1.0); 4.5292 (1.0); 4.5216 (1.1); 4.5201 (1.0); 3.7791 (1.6); 3.7695 (1.1); 3.7672 (1.7); 3.7555 (1.6); 3.4605 (16.0); 1.5765 (9.2); 1.4446 (3.7); 1.4279 (3.7); -0.0002 (15.2) I.1-58: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6736 (8.7); 8.6675 (10.8); 8.6173 (8.5); 8.6112 (7.0); 8.2721 (1.8); 8.2679 (10.8); 8.2630 (4.1); 8.2530 (10.6); 8.2518 (10.6); 8.2465 (12.4); 8.2423 (1.8); 8.0229 (4.4); 7.7852 (1.8); 7.7810 (11.2); 7.7762 (3.4); 7.7644 (3.3); 7.7596 (10.4); 7.7554 (1.5); 7.4576 (1.7); 7.4375 (1.8); 7.2614 (73.8); 6.9978 (0.5); 5.7313 (2.0); 5.7143 (2.4); 5.6951 (2.0); 5.6784 (0.5); 5.3002 (8.1); 2.7731 (2.1); 2.7607 (2.1); 2.7547 (5.3); 2.7399 (1.7); 2.7351 (2.1); 2.6850 (1.8); 2.6814 (1.9); 2.6667 (5.7); 2.6489 (2.2); 2.2473 (0.7); 2.1949 (1.2); 2.0455 (1.7); 1.9153 (2.0); 1.9089 (2.2); 1.8996 (6.1); 1.8963 (5.7); 1.8902 (7.7); 1.8841 (6.1); 1.8808 (6.0); 1.8714 (2.5); 1.8655 (2.0); 1.5784 (3.8); 1.4622 (15.9); 1.4455 (16.0); 1.3012 (0.6); 1.2825 (0.9); 1.2774 (1.2); 1.2636 (2.3); 1.2597 (2.5); 1.2418 (0.8); 0.8988 (1.2); 0.8819 (4.5); 0.8642 (1.6); 0.0079 (3.4); -0.0002 (117.3); -0.0060 (0.7); -0.0069 (0.6); - 0.0085 (3.2) BCS241005-Ausland STR 126 I.1-59: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6637 (2.5); 8.6577 (3.1); 8.6043 (2.9); 8.5981 (2.4); 8.2385 (3.2); 8.2343 (1.0); 8.2224 (1.1); 8.2179 (3.8); 8.2136 (0.6); 8.1390 (1.2); 8.1347 (2.0); 8.1307 (1.4); 8.0553 (2.0); 8.0269 (1.5); 8.0222 (2.3); 8.0177 (1.1); 7.7385 (3.4); 7.7342 (1.1); 7.7224 (1.0); 7.7179 (3.4); 7.7135 (0.5); 7.3628 (0.6); 7.3429 (0.6); 7.2607 (29.2); 5.6762 (0.7); 5.6586 (0.8); 5.6403 (0.7); 3.9755 (16.0); 1.5645 (1.4); 1.4321 (5.5); 1.4154 (5.5); 1.2640 (0.8); 0.8818 (1.4); 0.8639 (0.6); 0.0078 (1.0); -0.0002 (38.6); -0.0085 (1.1) I.1-60: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7007 (8.0); 8.6946 (9.5); 8.6246 (9.0); 8.6184 (7.9); 8.2873 (9.8); 8.2708 (3.4); 8.2663 (11.7); 8.1641 (3.9); 8.1597 (6.4); 8.1557 (4.7); 8.0913 (6.3); 8.0335 (4.8); 8.0289 (7.7); 8.0243 (4.0); 7.7848 (10.7); 7.7804 (3.4); 7.7639 (10.4); 7.5324 (2.2); 7.5184 (2.2); 7.5128 (2.4); 7.2600 (272.6); 7.2299 (0.9); 6.9965 (1.6); 5.7274 (0.6); 5.7113 (2.2); 5.6934 (2.7); 5.6752 (2.2); 5.3000 (7.3); 4.1495 (0.6); 4.1315 (1.3); 4.1136 (1.2); 2.1267 (2.8); 2.0461 (6.3); 1.4848 (15.9); 1.4680 (16.0); 1.4322 (1.1); 1.3326 (1.9); 1.2840 (3.0); 1.2778 (3.1); 1.2560 (11.5); 1.2421 (3.3); 1.2229 (1.8); 0.8800 (2.2); 0.8625 (1.3); 0.1593 (0.6); 0.1456 (1.5); 0.0690 (0.8); 0.0079 (10.0); -0.0002 (388.5); - 0.0085 (12.3); -0.0305 (1.2); -0.1497 (1.4) I.1-61: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6691 (3.9); 8.6630 (4.7); 8.6106 (3.8); 8.6044 (3.1); 8.2755 (0.8); 8.2714 (4.8); 8.2665 (1.6); 8.2499 (9.8); 8.0195 (2.1); 7.7544 (0.9); 7.7502 (5.1); 7.7454 (1.6); 7.7336 (1.6); 7.7289 (4.7); 7.7246 (0.7); 7.4570 (0.8); 7.4378 (0.8); 7.2610 (43.8); 5.7170 (0.9); 5.6999 (1.1); 5.6808 (0.9); 5.3002 (4.4); 4.5397 (1.8); 4.5376 (1.8); 4.5295 (2.3); 4.5281 (2.2); 4.5252 (2.1); 4.5233 (2.1); 4.5153 (2.0); 4.5136 (1.9); 4.1310 (0.5); 4.1132 (0.5); 3.8180 (3.1); 3.8118 (1.0); 3.8079 (2.4); 3.8058 (3.4); 3.8001 (0.9); 3.7938 (2.9); 3.6407 (2.2); 3.6231 (7.2); 3.6057 (7.3); 3.5882 (2.3); 2.1286 (1.2); 2.0456 (2.6); 1.5720 (2.4); 1.4595 (0.6); 1.4487 (7.4); 1.4320 (7.4); 1.2764 (7.6); 1.2589 (16.0); 1.2414 (7.7); 0.0080 (2.2); 0.0064 (0.9); 0.0056 (1.1); -0.0002 (64.3); -0.0050 (0.6); -0.0085 (1.6) I.1-62: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7655 (2.9); 8.7612 (2.9); 8.6667 (6.8); 8.6607 (8.4); 8.6423 (2.3); 8.6382 (2.3); 8.6302 (2.4); 8.6260 (2.3); 8.6127 (6.5); 8.6066 (5.2); 8.2709 (1.3); 8.2667 (8.1); 8.2619 (2.4); 8.2453 (15.2); 8.2418 (7.5); 8.0154 (3.2); 7.8569 (1.3); 7.8525 (1.9); 7.8514 (1.8); 7.8470 (1.2); 7.8372 (1.4); 7.8330 (2.0); 7.8317 (1.9); 7.8274 (1.3); 7.7678 (1.4); 7.7636 (8.4); 7.7587 (2.4); 7.7470 (2.5); 7.7422 (7.5); 7.7379 (1.1); 7.4646 (1.3); 7.4450 (1.3); 7.3878 (1.8); 7.3857 (1.7); 7.3756 (1.8); 7.3736 (1.7); 7.3682 (1.7); 7.3662 (1.6); 7.3560 (1.7); 7.3540 (1.5); 7.2622 (30.9); 5.6977 (1.5); 5.6806 (1.7); 5.6785 (1.6); 5.6614 (1.4); 5.4432 (12.8); 5.2997 (10.1); 4.1488 (0.7); 4.1310 (2.1); 4.1131 (2.1); 4.0953 (0.7); 2.2616 (0.8); 2.2477 (1.1); 2.1948 (2.0); 2.1035 (1.7); 2.0455 (10.3); 1.4494 (11.6); 1.4326 (11.5); 1.3214 (0.7); 1.3036 (1.6); 1.2907 (1.8); 1.2861 (2.0); 1.2832 (2.0); 1.2773 (5.2); 1.2645 (7.8); 1.2595 (11.0); 1.2447 (1.5); 1.2416 (3.9); 1.2273 (0.5); 0.8988 (4.2); 0.8819 (16.0); 0.8642 (5.8); 0.0080 (1.4); -0.0002 (48.9); -0.0085 (1.2) BCS241005-Ausland STR 127 I.1-63: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6784 (1.4); 8.6723 (1.7); 8.6356 (1.0); 8.6326 (1.9); 8.6290 (4.4); 8.6258 (1.4); 8.6078 (1.4); 8.6016 (1.2); 8.5325 (0.6); 8.2478 (1.7); 8.2313 (2.0); 8.2267 (2.9); 7.7421 (1.8); 7.7373 (0.6); 7.7208 (1.8); 7.5187 (0.6); 7.2603 (92.0); 4.1309 (0.5); 4.1131 (0.6); 3.9803 (8.8); 3.1604 (16.0); 3.1378 (6.6); 2.0454 (2.6); 1.5493 (6.3); 1.4618 (2.6); 1.4450 (2.6); 1.2842 (0.6); 1.2775 (0.9); 1.2596 (1.9); 1.2418 (0.7); 0.0079 (3.6); -0.0002 (139.8); -0.0085 (4.0) I.1-64: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6238 (1.4); 8.6197 (1.6); 8.5784 (1.5); 8.5745 (1.3); 8.2176 (2.0); 8.2038 (2.1); 7.7445 (2.0); 7.7307 (1.9); 7.6441 (1.5); 7.6418 (1.5); 7.4422 (0.7); 7.4395 (0.7); 7.4287 (0.8); 7.4260 (0.8); 7.2601 (36.6); 7.2488 (1.4); 7.2353 (1.2); 7.2114 (0.4); 7.1981 (0.4); 5.6568 (0.4); 5.6447 (0.6); 5.6327 (0.4); 4.5458 (5.7); 3.9680 (8.3); 3.2126 (0.4); 3.2088 (0.4); 1.5577 (2.2); 1.4004 (0.4); 1.3883 (3.3); 1.3771 (3.1); 1.3598 (0.3); 1.2529 (0.8); -0.0001 (50.0); -0.0055 (2.4) I.1-64: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6216 (3.8); 8.5759 (3.6); 8.2197 (4.1); 8.2015 (4.7); 7.7469 (4.6); 7.7284 (4.3); 7.6423 (4.1); 7.4438 (1.8); 7.4236 (2.3); 7.2608 (22.6); 7.2301 (2.4); 7.2018 (1.3); 5.6612 (1.1); 5.6436 (1.6); 5.6263 (1.1); 4.5457 (9.3); 3.9683 (16.0); 1.6027 (0.9); 1.4194 (0.8); 1.3911 (6.5); 1.3745 (6.7); 1.3582 (0.7); 1.2531 (0.6); -0.0002 (31.1) I.1-65: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6203 (2.3); 8.6163 (2.7); 8.5790 (2.6); 8.5751 (2.2); 8.2171 (3.2); 8.2032 (3.4); 7.7490 (3.3); 7.7351 (3.1); 7.5923 (2.4); 7.5894 (2.3); 7.4117 (1.2); 7.4086 (1.1); 7.3980 (1.4); 7.3949 (1.3); 7.2602 (37.4); 7.2008 (0.9); 7.1937 (2.6); 7.1885 (1.0); 7.1801 (2.1); 5.6582 (0.7); 5.6465 (1.0); 5.6341 (0.7); 3.9732 (1.0); 3.9667 (13.3); 3.9532 (0.3); 3.3294 (1.0); 3.3240 (1.8); 3.3208 (1.5); 3.3163 (1.8); 3.3125 (2.2); 3.3107 (2.1); 3.2872 (2.2); 3.2853 (2.1); 3.2815 (1.8); 3.2770 (1.7); 3.2742 (1.7); 3.2685 (1.1); 1.5800 (2.2); 1.3918 (5.2); 1.3806 (5.2); 1.3713 (0.5); 1.3600 (0.3); - 0.0001 (50.0) I.1-67: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.5255 (0.6); 9.5089 (0.7); 8.7108 (1.4); 8.7046 (2.1); 8.6815 (2.3); 8.6754 (1.9); 8.6699 (0.9); 8.6528 (3.7); 8.6486 (4.0); 8.4957 (1.0); 8.4916 (1.9); 8.4874 (1.0); 8.4333 (0.7); 8.2540 (1.6); 8.2498 (1.5); 8.0840 (1.9); 8.0794 (0.6); 8.0675 (0.6); 8.0628 (2.4); 7.8161 (2.1); 7.8114 (0.7); 7.7996 (0.6); 7.7949 (2.0); 5.3705 (0.6); 4.0379 (0.6); 4.0201 (0.6); 3.4101 (2.8); 3.3994 (5.9); 3.3637 (14.8); 2.5410 (16.7); 2.5242 (1.0); 2.5195 (1.3); 2.5107 (19.4); 2.5062 (42.6); 2.5016 (59.2); 2.4970 (41.1); 2.4924 (18.1); 1.9887 (2.8); 1.9088 (16.0); 1.5253 (2.3); 1.5080 (2.3); 1.2586 (0.5); 1.2348 (2.2); 1.1924 (1.2); 1.1746 (1.8); 1.1568 (0.8); 0.0080 (1.8); 0.0057 (0.7); -0.0002 (57.7); -0.0085 (1.4) BCS241005-Ausland STR 128 I.1-69: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6362 (2.8); 8.6302 (3.0); 8.5268 (2.2); 8.5207 (2.0); 8.2397 (3.3); 8.2384 (1.9); 8.2348 (1.0); 8.2232 (1.2); 8.2194 (2.4); 8.2182 (3.4); 7.7145 (0.5); 7.7104 (3.4); 7.7054 (1.0); 7.6937 (1.2); 7.6889 (3.6); 7.6847 (0.6); 7.6692 (0.9); 7.6673 (0.7); 7.2614 (18.0); 5.7782 (0.6); 5.7615 (0.6); 5.7575 (0.6); 5.7409 (0.5); 3.9713 (16.0); 1.5615 (0.5); 1.4029 (4.4); 1.3863 (4.4); 1.2552 (0.5); 0.0080 (0.6); -0.0002 (21.0); -0.0085 (0.6) I.1-70: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6442 (2.6); 8.6381 (3.2); 8.5900 (2.9); 8.5840 (2.3); 8.2289 (3.4); 8.2243 (1.3); 8.2122 (1.4); 8.2077 (3.7); 8.0562 (2.8); 8.0511 (2.7); 7.7410 (3.7); 7.7364 (1.3); 7.7243 (1.4); 7.7199 (3.4); 7.7033 (2.1); 7.6826 (3.1); 7.6006 (1.8); 7.5954 (1.7); 7.5799 (1.2); 7.5747 (1.2); 7.3095 (0.7); 7.2898 (0.7); 7.2620 (8.1); 5.6652 (0.8); 5.6482 (1.0); 5.6291 (0.8); 3.9716 (16.0); 2.0453 (0.6); 1.5886 (1.0); 1.4082 (5.7); 1.3915 (5.7); -0.0002 (10.2) I.1-71: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1227 (0.7); 9.0909 (2.8); 9.0747 (2.9); 8.6810 (4.4); 8.6754 (6.1); 8.6561 (6.2); 8.6505 (4.4); 8.1739 (6.3); 8.1700 (6.2); 8.0728 (6.5); 8.0524 (7.5); 7.9209 (0.8); 7.9003 (1.1); 7.8336 (4.0); 7.8128 (5.6); 7.7940 (7.6); 7.7737 (6.5); 7.7167 (3.3); 7.7126 (3.1); 7.6961 (2.3); 7.6915 (2.3); 5.3095 (1.7); 5.2926 (2.5); 5.2757 (1.7); 3.3260 (16.0); 2.6732 (0.5); 2.5039 (85.6); 1.4599 (9.5); 1.4428 (9.5); 1.2332 (1.1); -0.0002 (35.1) I.1-72: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6211 (2.3); 8.6171 (2.5); 8.5736 (2.4); 8.5698 (2.1); 8.2322 (3.0); 8.2184 (3.3); 7.7323 (3.3); 7.7185 (3.1); 7.6573 (2.3); 7.6551 (2.4); 7.4522 (1.1); 7.4496 (1.2); 7.4387 (1.3); 7.4361 (1.3); 7.3151 (0.9); 7.3015 (1.0); 7.2847 (36.4); 7.2481 (2.1); 7.2347 (1.8); 5.6572 (0.7); 5.6452 (1.0); 5.6334 (0.7); 4.5467 (8.7); 3.2113 (0.4); 3.2076 (0.4); 2.5839 (0.6); 2.0348 (0.3); 1.9511 (0.3); 1.3952 (5.0); 1.3841 (4.7); 1.2535 (0.8); -0.0001 (50.0); -0.0229 (0.3) I.1-73: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6479 (3.2); 8.6440 (3.8); 8.6043 (3.6); 8.6005 (3.1); 8.2313 (4.2); 8.2175 (4.6); 7.7536 (4.5); 7.7399 (4.3); 7.6325 (3.4); 7.6297 (3.6); 7.4518 (1.7); 7.4488 (1.7); 7.4381 (2.0); 7.4350 (2.0); 7.4251 (1.6); 7.4119 (1.6); 7.2602 (36.0); 7.2057 (3.1); 7.1919 (2.8); 5.7400 (1.0); 5.7279 (1.4); 5.7158 (1.1); 3.3341 (1.6); 3.3280 (2.5); 3.3210 (2.4); 3.3171 (2.9); 3.3150 (2.8); 3.2896 (2.7); 3.2875 (3.0); 3.2836 (2.5); 3.2766 (2.5); 3.2704 (1.6); 1.4647 (7.2); 1.4535 (7.2); 1.2531 (1.1); -0.0001 (50.0) BCS241005-Ausland STR 129 I.1-74: 1H-NMR(600.3 MHz, d6-DMSO): δ= 8.8897 (1.3); 8.8786 (1.3); 8.7235 (0.3); 8.7195 (0.4); 8.6987 (0.4); 8.6947 (0.3); 8.6761 (2.2); 8.6722 (2.9); 8.6499 (3.0); 8.6459 (2.3); 8.0906 (3.3); 8.0767 (3.7); 7.8405 (3.6); 7.8267 (3.2); 7.7377 (0.5); 7.7237 (0.6); 7.6419 (1.1); 7.6390 (1.3); 7.6282 (1.1); 7.6254 (1.6); 7.6169 (2.8); 7.2367 (2.0); 7.2229 (1.9); 5.3178 (0.8); 5.3065 (1.2); 5.2951 (0.8); 3.8986 (13.0); 3.8893 (0.4); 3.6012 (0.3); 3.3190 (19.6); 2.8903 (0.6); 2.7310 (0.5); 2.5364 (0.5); 2.5187 (0.8); 2.5009 (50.0); 2.4806 (0.3); 1.7598 (0.4); 1.4558 (4.7); 1.4442 (5.1); 1.4311 (0.8); 1.2350 (0.4); 1.1733 (0.3); -0.0001 (21.6) I.1-75: 1H-NMR(600.3 MHz, d6-DMSO): δ= 8.7435 (2.3); 8.7325 (2.3); 8.7235 (0.3); 8.7195 (0.4); 8.6987 (0.4); 8.6949 (0.3); 8.6677 (4.1); 8.6637 (5.3); 8.6406 (5.6); 8.6366 (4.2); 8.0872 (6.3); 8.0735 (7.0); 7.9528 (0.4); 7.8249 (6.8); 7.8111 (6.1); 7.7376 (0.4); 7.7240 (0.4); 7.5112 (0.6); 7.5090 (0.6); 7.4980 (0.7); 7.4956 (0.7); 7.4102 (1.2); 7.4007 (2.2); 7.3981 (2.6); 7.3874 (3.0); 7.3850 (3.1); 7.3285 (5.1); 7.3152 (3.6); 7.2834 (5.2); 7.2811 (5.0); 5.8408 (4.2); 5.8030 (17.2); 5.2849 (0.4); 5.2738 (1.6); 5.2624 (2.4); 5.2511 (1.6); 5.2396 (0.4); 3.9129 (0.4); 3.8998 (24.6); 3.8893 (0.6); 3.6011 (0.6); 3.3263 (8.1); 2.8902 (2.1); 2.7309 (1.9); 2.5038 (37.5); 2.5011 (50.0); 2.4984 (37.5); 1.7597 (0.7); 1.4845 (0.5); 1.4424 (0.8); 1.4258 (9.0); 1.4143 (9.0); 0.9419 (0.5); 0.0170 (0.4); -0.0001 (38.0) I.1-76: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6152 (0.8); 8.6111 (1.0); 8.5707 (0.9); 8.5667 (0.8); 8.2146 (1.2); 8.2008 (1.2); 7.7484 (1.2); 7.7346 (1.1); 7.2975 (0.4); 7.2839 (0.6); 7.2736 (1.0); 7.2705 (0.8); 7.2600 (38.3); 7.1007 (0.8); 7.0873 (0.7); 4.4344 (0.7); 4.4266 (0.7); 4.4188 (0.7); 3.9707 (0.8); 3.9662 (4.9); 3.1697 (0.7); 3.1619 (0.7); 3.1542 (0.7); 1.5527 (2.6); 1.3842 (1.8); 1.3730 (1.8); 1.2529 (0.9); 0.0691 (1.7); 0.0178 (0.3); 0.0053 (1.9); -0.0001 (50.0); -0.0054 (1.5) I.1-77: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6480 (1.5); 8.6440 (1.7); 8.5809 (1.6); 8.5768 (1.5); 8.2209 (2.2); 8.2099 (0.8); 8.2069 (2.4); 7.7660 (2.2); 7.7631 (0.8); 7.7520 (2.2); 7.5558 (1.6); 7.5522 (1.7); 7.4515 (0.9); 7.4478 (0.8); 7.4373 (0.9); 7.4336 (0.9); 7.2603 (38.2); 7.2180 (0.4); 7.2045 (0.5); 6.8547 (1.7); 6.8405 (1.6); 5.6606 (0.5); 5.6479 (0.6); 5.6362 (0.5); 4.4657 (1.4); 4.4603 (0.9); 4.4579 (1.4); 4.4555 (0.9); 4.4501 (1.5); 3.9734 (0.5); 3.9672 (10.5); 3.1495 (1.5); 3.1443 (0.9); 3.1417 (1.4); 3.1393 (0.9); 3.1340 (1.5); 2.9588 (0.6); 2.8859 (0.6); 2.0345 (0.3); 1.9947 (0.6); 1.5642 (0.6); 1.5473 (1.2); 1.5361 (1.1); 1.4544 (1.2); 1.4434 (1.2); 1.4111 (3.6); 1.3998 (3.6); 1.2529 (0.7); 1.0264 (0.3); 0.0053 (1.6); -0.0001 (50.0); -0.0056 (1.6); -0.0209 (0.3) BCS241005-Ausland STR 130 I.1-78: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6756 (0.5); 8.6715 (0.6); 8.6210 (4.5); 8.6170 (5.5); 8.5919 (0.5); 8.5878 (0.6); 8.5786 (5.0); 8.5746 (4.3); 8.2175 (6.4); 8.2038 (6.6); 8.0191 (0.7); 7.7494 (6.2); 7.7355 (5.8); 7.6579 (0.8); 7.6426 (4.6); 7.6395 (4.6); 7.4860 (2.3); 7.4828 (2.3); 7.4721 (2.5); 7.4689 (2.4); 7.2674 (0.4); 7.2607 (38.2); 7.2527 (0.5); 7.1820 (1.2); 7.1689 (1.3); 6.8400 (4.4); 6.8261 (4.2); 5.7589 (20.4); 5.6715 (0.3); 5.6602 (1.3); 5.6486 (1.6); 5.6359 (1.3); 5.6247 (0.4); 4.1280 (0.3); 4.1161 (0.3); 3.9732 (3.5); 3.9677 (27.6); 3.9599 (0.8); 3.9532 (0.5); 2.9565 (5.9); 2.8845 (5.3); 2.0449 (1.4); 1.5665 (1.9); 1.3886 (9.9); 1.3775 (10.1); 1.3711 (1.7); 1.3599 (1.3); 1.2713 (0.5); 1.2594 (1.0); 1.2536 (0.6); 1.2476 (0.5); 0.0696 (0.3); 0.0053 (1.7); -0.0001 (50.0); -0.0055 (2.3) I.1-83: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6821 (1.0); 8.6760 (1.4); 8.6532 (1.7); 8.6472 (1.2); 8.0829 (1.4); 8.0615 (1.6); 7.8152 (1.6); 7.7938 (1.3); 7.5737 (0.6); 7.5695 (0.8); 7.5649 (0.7); 7.3821 (0.5); 7.3784 (1.0); 7.3746 (0.5); 7.3007 (0.6); 7.2963 (0.9); 3.8982 (6.3); 3.3180 (16.0); 2.5237 (1.1); 2.5190 (1.5); 2.5103 (22.0); 2.5057 (48.2); 2.5011 (67.6); 2.4965 (46.3); 2.4920 (20.1); 1.4586 (1.6); 1.4413 (1.6); 0.9945 (0.6); 0.9889 (0.7); 0.9734 (0.6); 0.9679 (0.6); 0.8582 (0.6); 0.7495 (0.6); 0.7454 (0.5); 0.7372 (0.5); 0.0079 (0.9); -0.0002 (32.3); -0.0027 (1.1); -0.0085 (0.9) I.1-84: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6710 (0.5); 8.6643 (0.6); 8.6476 (0.7); 8.0787 (0.6); 8.0575 (0.6); 7.8214 (0.6); 3.8983 (1.3); 3.3184 (16.0); 2.5236 (1.1); 2.5189 (1.5); 2.5102 (18.8); 2.5056 (42.1); 2.5011 (61.0); 2.4964 (38.9); 2.4919 (16.8); 1.4570 (0.8); 1.4398 (0.8); 0.0079 (1.0); -0.0002 (35.0); -0.0085 (1.0) I.1-85: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7583 (1.4); 8.7417 (1.5); 8.6629 (3.6); 8.6567 (5.0); 8.6388 (5.9); 8.6327 (3.8); 8.0917 (0.5); 8.0742 (4.7); 8.0699 (1.9); 8.0577 (1.7); 8.0529 (5.4); 7.8293 (0.6); 7.8054 (5.1); 7.8006 (1.6); 7.7888 (1.6); 7.7842 (4.4); 7.4160 (1.7); 7.4121 (1.7); 7.3961 (2.5); 7.3920 (2.8); 7.3350 (4.3); 7.3150 (2.7); 7.2985 (3.7); 7.2948 (3.4); 7.2858 (0.6); 5.8412 (1.8); 5.8046 (16.0); 5.2862 (0.9); 5.2695 (1.4); 5.2525 (0.9); 3.8998 (2.1); 3.7847 (0.6); 2.6749 (0.7); 2.6703 (1.0); 2.6658 (0.7); 2.5328 (0.9); 2.5281 (1.5); 2.5240 (3.6); 2.5194 (4.8); 2.5106 (59.3); 2.5061 (126.7); 2.5015 (174.5); 2.4969 (119.8); 2.4924 (52.0); 2.4680 (0.5); 2.3331 (0.8); 2.3286 (1.0); 2.3240 (0.7); 1.4276 (5.8); 1.4104 (5.8); 0.0080 (3.0); -0.0002 (97.7); -0.0059 (0.9); -0.0068 (0.8); -0.0085 (2.7) BCS241005-Ausland STR 131 I.1-87: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7224 (3.6); 8.7059 (3.7); 8.6601 (8.6); 8.6539 (13.3); 8.6352 (16.0); 8.6291 (11.1); 8.0753 (12.2); 8.0706 (3.9); 8.0588 (4.4); 8.0540 (14.7); 8.0499 (2.1); 7.8085 (13.6); 7.8036 (4.1); 7.7919 (3.9); 7.7872 (11.7); 7.7830 (1.7); 7.6227 (9.4); 7.6173 (9.8); 7.4683 (5.6); 7.4629 (4.9); 7.4470 (5.9); 7.4415 (5.7); 6.8291 (10.9); 6.8078 (10.4); 5.2764 (2.3); 5.2595 (3.6); 5.2426 (2.4); 4.4032 (5.5); 4.3951 (4.7); 4.3917 (5.5); 4.3880 (4.6); 4.3801 (5.5); 3.9004 (0.5); 3.4359 (3.6); 3.2096 (5.9); 3.2017 (4.6); 3.1981 (5.7); 3.1945 (4.5); 3.1866 (5.3); 2.6753 (1.0); 2.6706 (1.4); 2.6660 (1.0); 2.5244 (4.5); 2.5197 (6.2); 2.5110 (79.4); 2.5064 (171.2); 2.5018 (237.6); 2.4972 (162.2); 2.4927 (70.1); 2.4711 (1.0); 2.4665 (1.1); 2.3335 (1.0); 2.3289 (1.4); 2.3243 (1.0); 1.4233 (14.2); 1.4060 (14.1); 0.0268 (0.6); 0.0080 (4.4); -0.0002 (155.6); -0.0053 (1.0); -0.0061 (0.9); -0.0070 (0.8); -0.0085 (4.0); -0.0309 (0.5) I.1-88: 1H-NMR(400.6 MHz, CDCl3): δ= 8.0523 (0.8); 8.0311 (0.9); 7.6924 (0.7); 7.6739 (0.5); 7.6715 (1.0); 7.6692 (0.6); 7.5736 (0.6); 7.5712 (0.6); 7.4530 (0.5); 7.4503 (0.5); 7.4321 (0.6); 7.2601 (42.0); 6.2278 (6.9); 2.6383 (0.6); 1.5382 (16.0); 0.0080 (1.4); -0.0002 (45.9); -0.0085 (1.3) I.1-89: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6353 (2.3); 8.6293 (3.1); 8.5917 (2.4); 8.5857 (1.9); 8.2373 (2.9); 8.2325 (1.0); 8.2208 (1.0); 8.2159 (3.4); 8.2117 (0.5); 8.1466 (0.9); 8.1420 (1.6); 8.1373 (1.0); 8.0074 (1.6); 8.0060 (1.8); 8.0011 (1.7); 7.9998 (1.7); 7.9003 (0.6); 7.8978 (0.7); 7.8947 (0.6); 7.8921 (0.7); 7.8801 (0.8); 7.8775 (0.8); 7.8744 (0.8); 7.8719 (0.7); 7.7709 (3.2); 7.7659 (1.0); 7.7564 (1.8); 7.7534 (2.2); 7.7510 (2.5); 7.7495 (3.2); 7.7292 (0.6); 7.7265 (0.8); 7.7225 (0.6); 7.7098 (0.8); 7.7058 (1.0); 7.7032 (0.8); 7.5569 (1.1); 7.5373 (1.8); 7.5184 (1.1); 7.2602 (85.9); 6.5088 (1.5); 6.5043 (1.6); 6.5026 (1.7); 6.4981 (1.5); 5.7223 (0.6); 5.7055 (0.6); 5.6858 (0.6); 3.9726 (16.0); 1.5512 (4.9); 1.4390 (4.7); 1.4222 (4.7); 0.0079 (3.2); -0.0002 (123.3); -0.0085 (3.5) I.1-90: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6622 (2.4); 8.6561 (3.1); 8.6052 (2.6); 8.5991 (2.2); 8.2445 (4.9); 8.2400 (7.5); 8.2228 (1.1); 8.2180 (3.7); 8.2141 (2.4); 8.2099 (2.8); 8.2056 (1.2); 7.7383 (3.2); 7.7335 (1.1); 7.7217 (0.9); 7.7170 (3.1); 7.5186 (0.7); 7.4064 (0.6); 7.3859 (0.6); 7.2602 (133.3); 6.9966 (0.7); 5.6816 (0.6); 5.6625 (0.8); 5.6454 (0.6); 4.1310 (1.1); 4.1132 (1.1); 3.9768 (16.0); 3.1194 (1.6); 3.1080 (14.9); 2.0455 (5.1); 1.5459 (3.4); 1.4356 (4.9); 1.4189 (4.9); 1.2776 (1.5); 1.2598 (3.1); 1.2419 (1.5); 0.8638 (1.1); 0.8589 (1.8); 0.8360 (0.5); 0.8330 (0.6); 0.1457 (0.6); 0.0296 (0.6); 0.0112 (1.0); 0.0105 (0.9); 0.0080 (4.9); 0.0057 (1.6); 0.0048 (2.0); -0.0002 (183.5); -0.0065 (1.7); -0.0085 (5.1); - 0.1494 (0.5) BCS241005-Ausland STR 132 I.1-94: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6920 (2.7); 8.6859 (3.1); 8.6179 (2.6); 8.6118 (2.2); 8.5304 (1.8); 8.5263 (2.2); 8.5257 (2.2); 8.5216 (1.7); 8.4457 (0.7); 8.3909 (0.6); 8.3519 (1.8); 8.3469 (3.0); 8.3419 (1.5); 8.2686 (0.6); 8.2443 (3.2); 8.2395 (1.0); 8.2277 (1.1); 8.2229 (3.5); 8.2187 (0.5); 8.1764 (0.5); 8.1728 (0.6); 8.1690 (1.8); 8.1648 (2.3); 8.1604 (1.6); 7.7543 (0.9); 7.7500 (3.4); 7.7452 (1.1); 7.7334 (1.0); 7.7286 (3.1); 7.6212 (0.6); 7.6017 (0.6); 7.2628 (8.8); 5.6966 (0.7); 5.6794 (0.8); 5.6606 (0.6); 3.9783 (16.0); 3.1506 (0.5); 3.0210 (0.5); 1.4594 (5.0); 1.4426 (5.0); -0.0002 (14.2) I.1-95: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6748 (0.9); 8.6687 (1.4); 8.6498 (1.7); 8.6437 (1.1); 8.0698 (1.3); 8.0485 (1.5); 7.7957 (1.4); 7.7744 (1.2); 7.5954 (0.6); 7.5913 (0.9); 7.5866 (0.6); 7.3991 (0.5); 7.3953 (0.9); 7.3915 (0.5); 7.3030 (0.6); 7.2985 (0.9); 4.0378 (0.5); 4.0201 (0.5); 3.3191 (16.0); 2.5238 (1.0); 2.5192 (1.5); 2.5105 (21.5); 2.5059 (46.9); 2.5013 (65.4); 2.4967 (44.7); 2.4921 (19.4); 1.9887 (2.5); 1.9085 (0.5); 1.4557 (1.5); 1.4385 (1.5); 1.1923 (0.7); 1.1745 (1.5); 1.1567 (0.7); 0.9951 (0.6); 0.9894 (0.7); 0.9740 (0.6); 0.9684 (0.7); 0.7553 (0.6); 0.7522 (0.5); 0.0080 (0.8); -0.0002 (26.2); - 0.0026 (0.9); -0.0085 (0.6) I.1-96: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6455 (2.5); 8.6394 (3.2); 8.5934 (2.4); 8.5873 (2.0); 8.5277 (2.3); 8.5222 (2.3); 8.2316 (3.0); 8.2268 (0.9); 8.2151 (1.0); 8.2102 (3.3); 7.9967 (1.2); 7.9912 (1.1); 7.9761 (1.6); 7.9706 (1.6); 7.8779 (2.7); 7.8573 (1.9); 7.7495 (0.5); 7.7453 (3.3); 7.7404 (1.0); 7.7287 (1.0); 7.7239 (3.0); 7.2647 (9.4); 5.6848 (0.6); 5.6677 (0.7); 5.6658 (0.6); 5.6486 (0.6); 4.1486 (0.8); 4.1307 (2.4); 4.1129 (2.5); 4.0951 (0.8); 3.9730 (15.8); 3.3202 (16.0); 2.1265 (0.6); 2.0456 (12.2); 1.6332 (1.0); 1.4298 (4.7); 1.4182 (0.8); 1.4130 (4.7); 1.2773 (3.5); 1.2595 (7.1); 1.2417 (3.4); 0.8591 (0.6); - 0.0002 (11.8) I.1-97: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.0992 (0.8); 9.3866 (1.5); 9.3702 (1.5); 8.6979 (3.1); 8.6918 (4.6); 8.6712 (5.0); 8.6652 (3.4); 8.5703 (2.2); 8.5654 (3.0); 8.5615 (2.4); 8.4244 (2.2); 8.4195 (4.0); 8.4144 (2.1); 8.2895 (2.4); 8.2853 (3.3); 8.2810 (2.2); 8.0632 (4.3); 8.0589 (1.6); 8.0467 (1.7); 8.0422 (5.2); 7.7847 (4.9); 7.7802 (1.7); 7.7681 (1.6); 7.7637 (4.3); 5.3558 (1.0); 5.3389 (1.5); 5.3219 (1.0); 3.3256 (16.0); 2.5259 (1.0); 2.5211 (1.5); 2.5124 (17.0); 2.5080 (35.7); 2.5034 (48.6); 2.4989 (34.3); 2.4944 (15.7); 1.5037 (5.6); 1.4864 (5.6); 1.2330 (0.9); -0.0002 (8.7) I.1-98: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6460 (2.5); 8.6399 (3.2); 8.5962 (2.3); 8.5901 (1.9); 8.2873 (2.0); 8.2816 (2.2); 8.2313 (3.0); 8.2265 (0.9); 8.2148 (0.9); 8.2099 (3.3); 8.0884 (1.1); 8.0826 (1.1); 8.0665 (1.2); 8.0607 (1.2); 7.7461 (3.0); 7.7413 (0.9); 7.7296 (0.9); 7.7247 (2.8); 7.2609 (33.0); 7.1632 (1.7); 7.1411 (1.6); 5.6851 (0.5); 5.6683 (0.6); 5.6489 (0.5); 4.0231 (12.9); 3.9727 (16.0); 2.1347 (0.6); 1.5573 (2.7); 1.4244 (0.5); 1.4186 (4.5); 1.4018 (4.5); 0.0079 (1.2); -0.0002 (41.9); -0.0027 (1.8); -0.0044 (0.6); -0.0085 (1.2) BCS241005-Ausland STR 133 I.1-99: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1000 (0.7); 9.0507 (0.9); 9.0343 (0.9); 8.6784 (1.9); 8.6723 (2.9); 8.6528 (3.2); 8.6467 (2.2); 8.3970 (2.2); 8.3913 (2.3); 8.1309 (1.0); 8.1253 (1.0); 8.1088 (1.2); 8.1032 (1.1); 8.0701 (2.6); 8.0657 (1.0); 8.0536 (1.0); 8.0490 (3.3); 7.8023 (3.0); 7.7978 (1.0); 7.7857 (0.9); 7.7812 (2.6); 7.4212 (1.8); 7.3987 (1.7); 5.3203 (0.6); 5.3035 (0.9); 5.2866 (0.6); 3.9712 (10.7); 3.3217 (16.0); 2.5245 (0.9); 2.5198 (1.4); 2.5111 (19.6); 2.5066 (41.9); 2.5020 (57.9); 2.4975 (40.7); 2.4930 (18.7); 1.4643 (3.4); 1.4471 (3.4); 0.0080 (1.4); -0.0002 (41.9); -0.0085 (1.4) I.1-100: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6925 (2.8); 8.6864 (3.5); 8.6278 (2.8); 8.6217 (2.4); 8.2879 (3.2); 8.2832 (1.7); 8.2792 (3.7); 8.2781 (3.7); 8.2754 (3.6); 8.2733 (3.9); 8.2666 (3.8); 8.2219 (1.9); 8.2176 (2.8); 8.2134 (1.5); 7.7815 (3.4); 7.7768 (1.1); 7.7649 (1.0); 7.7603 (3.2); 7.6088 (0.8); 7.5893 (0.8); 7.2606 (52.4); 5.7253 (0.6); 5.7066 (0.8); 5.6891 (0.6); 5.3002 (8.3); 3.1312 (1.7); 3.1126 (16.0); 1.4941 (4.6); 1.4773 (4.6); 0.0079 (1.7); -0.0002 (69.8); -0.0085 (2.1) I.1-101: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6581 (8.7); 8.6521 (11.8); 8.6138 (9.3); 8.6077 (7.4); 8.2679 (10.2); 8.2631 (3.5); 8.2514 (3.5); 8.2466 (11.9); 8.2132 (0.6); 8.1942 (3.5); 8.1896 (6.1); 8.1849 (3.8); 8.0330 (6.8); 8.0280 (6.7); 8.0268 (6.8); 7.9172 (2.3); 7.9147 (2.7); 7.9115 (2.4); 7.9091 (2.6); 7.8969 (2.7); 7.8944 (2.9); 7.8913 (2.7); 7.8888 (2.8); 7.8793 (0.5); 7.7899 (11.3); 7.7851 (3.5); 7.7734 (3.4); 7.7686 (11.2); 7.7643 (9.7); 7.7601 (9.1); 7.7451 (3.3); 7.7412 (3.7); 7.7385 (2.9); 7.5707 (5.2); 7.5510 (8.0); 7.5310 (3.1); 7.5187 (1.6); 7.2914 (0.6); 7.2602 (283.2); 7.2330 (0.6); 6.9966 (1.5); 6.5143 (5.7); 6.5097 (6.1); 6.5081 (6.3); 6.5035 (5.6); 5.8074 (0.6); 5.7909 (2.0); 5.7715 (2.3); 5.7542 (2.1); 5.7378 (0.6); 5.2999 (13.2); 3.9734 (2.4); 3.3186 (2.4); 1.5004 (15.9); 1.4837 (16.0); 1.4346 (1.2); 1.4176 (1.0); 1.3327 (0.6); 1.2843 (0.9); 1.2545 (1.4); 1.2464 (0.9); 0.1456 (1.0); 0.0691 (0.6); 0.0309 (0.9); 0.0079 (9.4); -0.0002 (372.8); -0.0085 (10.6); -0.0275 (0.6); -0.1494 (1.2) I.1-115: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1924 (0.5); 9.1757 (0.5); 8.9786 (6.1); 8.6942 (1.2); 8.6881 (1.9); 8.6677 (2.2); 8.6616 (1.5); 8.0664 (1.8); 8.0617 (0.6); 8.0500 (0.6); 8.0451 (2.1); 7.7914 (2.0); 7.7866 (0.6); 7.7749 (0.6); 7.7701 (1.7); 5.3276 (0.5); 4.0378 (0.5); 4.0201 (0.5); 3.3189 (16.0); 2.6701 (0.5); 2.6517 (6.1); 2.5407 (1.2); 2.5239 (1.6); 2.5192 (2.2); 2.5105 (26.9); 2.5059 (58.3); 2.5013 (81.6); 2.4967 (55.7); 2.4921 (24.0); 1.9887 (2.5); 1.9085 (1.0); 1.4819 (2.1); 1.4647 (2.0); 1.3551 (0.7); 1.1923 (0.8); 1.1745 (1.6); 1.1567 (0.8); 0.0080 (1.3); 0.0040 (0.6); -0.0002 (43.9); -0.0085 (1.1) I.1-116: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6693 (0.8); 8.6631 (1.3); 8.6455 (1.5); 8.6394 (1.0); 8.0707 (1.1); 8.0494 (1.4); 7.8027 (1.2); 7.7815 (1.1); 7.5877 (0.8); 7.5644 (0.8); 3.3182 (16.0); 2.5404 (1.2); 2.5342 (0.5); 2.5298 (0.6); 2.5236 (1.6); 2.5190 (2.1); 2.5102 (26.6); 2.5057 (57.6); 2.5010 (80.3); 2.4964 (54.6); 2.4919 (23.5); 2.2608 (1.5); 2.2573 (1.5); 1.9885 (1.8); 1.4476 (1.4); 1.4303 (1.4); 1.1922 (0.5); 1.1744 (1.1); 1.1566 (0.5); 0.0080 (1.1); -0.0002 (42.1); -0.0085 (1.1) BCS241005-Ausland STR 134 I.1-117: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9503 (0.6); 8.9308 (0.7); 8.7531 (1.6); 8.7470 (2.1); 8.7145 (2.7); 8.7084 (2.1); 8.4724 (1.6); 8.4716 (1.5); 8.4582 (1.6); 8.4574 (1.6); 8.1090 (2.2); 8.1043 (0.7); 8.0926 (0.7); 8.0878 (2.5); 7.7788 (2.3); 7.7739 (0.7); 7.7622 (0.7); 7.7575 (2.1); 7.4826 (1.5); 7.4767 (1.5); 7.1740 (1.2); 7.1673 (1.1); 7.1598 (1.1); 7.1531 (1.1); 5.3719 (0.5); 3.8767 (9.6); 3.3187 (16.0); 2.6701 (0.6); 2.5407 (1.4); 2.5240 (2.0); 2.5193 (2.5); 2.5105 (32.4); 2.5059 (70.5); 2.5014 (98.4); 2.4968 (67.4); 2.4922 (29.0); 2.3284 (0.6); 1.9887 (1.5); 1.4323 (2.7); 1.4155 (2.7); 1.3551 (0.8); 1.1746 (1.0); 0.0080 (1.4); -0.0002 (51.5); -0.0085 (1.4) I.1-118: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9637 (2.1); 8.9604 (2.0); 8.9216 (0.8); 8.9027 (0.8); 8.7376 (1.9); 8.7314 (2.7); 8.7068 (3.3); 8.7007 (2.4); 8.6204 (1.7); 8.6193 (1.8); 8.6169 (1.8); 8.6157 (1.6); 8.0933 (2.7); 8.0886 (0.8); 8.0768 (0.9); 8.0720 (3.2); 7.7747 (2.9); 7.7699 (0.9); 7.7582 (0.8); 7.7535 (2.6); 5.4029 (0.6); 5.3851 (0.7); 5.3672 (0.6); 3.3189 (16.0); 2.6703 (0.6); 2.5832 (7.9); 2.5409 (1.3); 2.5241 (1.7); 2.5194 (2.4); 2.5106 (33.8); 2.5061 (74.3); 2.5015 (103.9); 2.4969 (71.3); 2.4923 (31.1); 2.3286 (0.6); 1.9888 (1.9); 1.9087 (0.6); 1.4435 (3.4); 1.4266 (3.4); 1.3551 (1.0); 1.1924 (0.6); 1.1746 (1.2); 1.1568 (0.6); 0.0081 (1.5); -0.0002 (53.6); -0.0085 (1.4) I.1-119: 1H-NMR(400.6 MHz, CDCl3): δ= 8.5370 (0.8); 8.5270 (0.8); 8.2713 (0.8); 8.2499 (0.9); 8.2090 (0.7); 8.1797 (0.6); 8.1698 (0.5); 7.7159 (0.8); 7.6945 (0.8); 7.2601 (45.7); 3.9737 (4.2); 1.7005 (1.4); 1.6829 (1.4); 1.5368 (16.0); 0.0080 (1.7); -0.0002 (59.9); -0.0085 (1.6) I.1-120: 1H-NMR(400.6 MHz, CDCl3): δ= 8.4614 (2.3); 8.4512 (2.5); 8.2811 (0.7); 8.2611 (0.8); 8.2294 (2.8); 8.1989 (3.1); 8.1888 (2.9); 8.0225 (1.3); 7.3022 (0.5); 7.2826 (0.5); 7.2617 (10.7); 5.2998 (1.3); 5.1883 (0.6); 5.1710 (0.7); 5.1692 (0.7); 5.1520 (0.6); 3.9755 (16.0); 2.1276 (1.6); 1.4328 (0.8); 1.4186 (1.2); 1.4140 (4.8); 1.3970 (4.7); 1.3334 (0.8); 1.2846 (1.2); 1.2553 (2.3); -0.0002 (14.2) I.1-121: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3113 (1.0); 9.2951 (1.1); 8.6865 (2.4); 8.6804 (3.7); 8.6623 (4.3); 8.6563 (2.9); 8.4201 (2.4); 8.4152 (2.4); 8.0682 (3.4); 8.0636 (1.1); 8.0518 (1.2); 8.0470 (4.1); 8.0399 (0.9); 8.0348 (0.7); 8.0192 (2.2); 8.0141 (2.3); 8.0012 (3.6); 7.9809 (1.1); 7.7949 (3.8); 7.7902 (1.1); 7.7784 (1.0); 7.7737 (3.2); 5.7568 (3.2); 5.3359 (0.7); 5.3188 (1.0); 5.3022 (0.7); 3.8950 (0.6); 3.3812 (16.0); 3.3489 (5.0); 3.1679 (1.8); 2.6746 (0.9); 2.6700 (1.2); 2.6654 (0.9); 2.5405 (2.9); 2.5345 (0.7); 2.5306 (0.6); 2.5237 (3.3); 2.5191 (4.8); 2.5103 (69.4); 2.5057 (150.7); 2.5011 (209.8); 2.4965 (144.1); 2.4920 (62.6); 2.3328 (0.9); 2.3282 (1.2); 2.3235 (0.8); 1.4744 (4.0); 1.4571 (3.9); 1.0551 (0.8); 0.0080 (3.5); -0.0002 (116.8); -0.0059 (0.7); -0.0085 (3.0) BCS241005-Ausland STR 135 I.1-122: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6666 (8.5); 8.6606 (11.0); 8.6163 (8.6); 8.6102 (6.9); 8.5957 (0.6); 8.2725 (10.0); 8.2678 (3.2); 8.2560 (3.3); 8.2512 (11.3); 8.2185 (0.7); 8.1373 (3.4); 8.1325 (5.5); 8.1278 (3.8); 8.0270 (13.0); 8.0255 (12.8); 7.9930 (0.7); 7.8602 (2.2); 7.8578 (2.6); 7.8545 (2.2); 7.8521 (2.4); 7.8400 (2.7); 7.8375 (2.9); 7.8343 (2.8); 7.8319 (2.7); 7.7903 (10.7); 7.7856 (3.5); 7.7738 (6.0); 7.7691 (11.3); 7.7573 (3.1); 7.7533 (3.6); 7.7506 (3.2); 7.6734 (11.3); 7.6721 (11.1); 7.5763 (3.9); 7.5563 (7.7); 7.5369 (4.4); 7.5187 (2.3); 7.2888 (1.1); 7.2685 (1.4); 7.2602 (409.9); 7.2372 (1.2); 7.2299 (0.7); 6.9966 (2.2); 5.7980 (0.6); 5.7813 (1.8); 5.7622 (2.2); 5.7448 (1.8); 5.7285 (0.6); 5.3001 (16.0); 3.9742 (2.7); 2.7788 (12.6); 1.4955 (15.3); 1.4788 (15.3); 1.4449 (1.4); 1.4281 (1.3); 1.2554 (2.0); 1.2464 (1.4); 0.1458 (1.3); 0.0690 (1.8); 0.0284 (1.3); 0.0111 (1.3); 0.0080 (12.8); -0.0002 (440.4); -0.0059 (5.4); - 0.0085 (12.0); -0.0233 (1.0); -0.0304 (0.8); -0.1494 (1.5) I.1-123: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6408 (2.6); 8.6347 (3.3); 8.5941 (2.9); 8.5881 (2.2); 8.2374 (3.2); 8.2329 (1.1); 8.2209 (1.2); 8.2164 (3.7); 8.0851 (1.3); 8.0806 (1.9); 8.0758 (1.2); 7.9854 (4.0); 7.8353 (0.8); 7.8319 (0.8); 7.8296 (0.8); 7.8149 (1.0); 7.8118 (0.9); 7.7653 (3.6); 7.7607 (1.2); 7.7441 (4.2); 7.7398 (1.3); 7.7232 (1.2); 7.6689 (3.6); 7.5633 (1.3); 7.5435 (2.1); 7.5237 (1.0); 7.4012 (0.7); 7.3811 (0.7); 7.2604 (59.8); 5.7143 (0.7); 5.6963 (0.8); 5.6781 (0.7); 3.9741 (16.0); 2.9217 (1.7); 2.7757 (7.8); 2.0077 (1.6); 1.5524 (6.0); 1.4368 (5.5); 1.4200 (5.5); 0.0691 (0.7); 0.0079 (2.5); -0.0002 (73.8); - 0.0084 (2.2) I.1-124: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6395 (0.8); 8.6334 (1.0); 8.5937 (0.8); 8.5876 (0.6); 8.2375 (1.0); 8.2160 (1.1); 8.0166 (1.1); 8.0151 (1.2); 7.7647 (1.0); 7.7479 (0.5); 7.7433 (1.2); 7.7007 (1.0); 7.6995 (1.0); 7.5453 (0.6); 7.2602 (51.7); 3.9741 (5.0); 2.7763 (3.7); 1.5421 (16.0); 1.4358 (1.5); 1.4191 (1.5); 0.0079 (1.5); -0.0002 (57.6); -0.0061 (0.5); -0.0085 (1.6) I.1-125: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8190 (0.9); 8.8017 (0.9); 8.7165 (2.3); 8.7105 (3.0); 8.6738 (3.7); 8.6677 (2.9); 8.1219 (3.2); 8.1171 (0.9); 8.1053 (1.1); 8.1005 (3.6); 7.8300 (0.6); 7.8258 (3.5); 7.8209 (1.0); 7.8092 (1.0); 7.8044 (3.0); 7.0621 (6.2); 6.7894 (6.2); 6.0953 (8.5); 5.7569 (5.5); 5.2485 (0.6); 5.2314 (1.0); 5.2142 (0.6); 3.9078 (13.4); 3.3192 (16.0); 2.5407 (0.7); 2.5239 (1.0); 2.5192 (1.4); 2.5105 (17.6); 2.5059 (38.2); 2.5013 (53.1); 2.4967 (36.2); 2.4922 (15.6); 1.9887 (1.1); 1.4195 (3.7); 1.4025 (3.7); 1.1745 (0.7); 0.0080 (1.2); -0.0002 (42.6); -0.0085 (1.1) I.1-126: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6638 (2.4); 8.6577 (2.9); 8.5972 (2.3); 8.5911 (1.9); 8.2724 (2.1); 8.2520 (2.4); 8.2382 (2.9); 8.2334 (0.9); 8.2217 (1.0); 8.2168 (3.2); 8.2048 (2.3); 8.2007 (2.3); 7.9028 (1.4); 7.8986 (1.3); 7.8824 (1.2); 7.8782 (1.2); 7.7391 (3.1); 7.7343 (0.9); 7.7226 (0.9); 7.7177 (2.8); 7.4600 (0.5); 7.4405 (0.5); 7.2628 (20.0); 5.6825 (0.6); 5.6655 (0.6); 5.6464 (0.6); 3.9772 (14.8); 3.3012 (16.0); 2.9589 (1.6); 2.8861 (1.4); 2.8847 (1.3); 2.1305 (0.6); 1.4279 (4.4); 1.4219 (0.6); 1.4112 (4.4); -0.0002 (13.4) BCS241005-Ausland STR 136 I.1-127: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6566 (6.0); 8.6505 (8.4); 8.6111 (6.8); 8.6051 (5.0); 8.2720 (7.9); 8.2506 (8.9); 8.1250 (4.0); 8.0705 (9.2); 7.8567 (1.8); 7.8364 (2.2); 7.7925 (8.3); 7.7711 (9.2); 7.7669 (3.6); 7.7448 (11.1); 7.5737 (3.2); 7.5536 (4.5); 7.5339 (2.5); 7.5187 (4.8); 7.4703 (1.4); 7.2603 (837.8); 7.2462 (1.2); 7.2297 (2.5); 6.9966 (4.5); 5.7606 (1.4); 5.7415 (1.8); 5.7248 (1.5); 1.5478 (16.0); 1.4782 (12.2); 1.4614 (11.6); 1.2559 (2.8); 0.1456 (2.9); 0.0328 (1.3); 0.0080 (24.5); -0.0002 (903.2); - 0.0085 (24.5); -0.0309 (2.4); -0.1496 (2.9) I.1-128: 1H-NMR(400.6 MHz, CDCl3): δ= 8.8117 (1.6); 8.8105 (1.7); 8.8056 (1.7); 8.8043 (1.6); 8.6565 (2.6); 8.6504 (3.1); 8.5855 (2.6); 8.5795 (2.3); 8.2381 (0.5); 8.2339 (3.2); 8.2292 (1.1); 8.2174 (1.1); 8.2127 (3.5); 8.2086 (0.6); 8.1072 (1.4); 8.1010 (1.4); 8.0865 (1.5); 8.0802 (1.5); 7.7442 (0.6); 7.7401 (3.5); 7.7354 (1.1); 7.7235 (1.1); 7.7188 (3.2); 7.7148 (0.6); 7.4297 (2.4); 7.4283 (2.4); 7.4090 (2.3); 7.4076 (2.2); 7.2633 (8.4); 5.6937 (0.7); 5.6749 (0.8); 5.6576 (0.7); 3.9739 (16.0); 2.0457 (0.6); 1.4209 (5.4); 1.4041 (5.4); -0.0002 (9.0) I.1-129: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7096 (1.0); 8.7035 (1.3); 8.6705 (1.6); 8.6644 (1.2); 8.0978 (1.3); 8.0766 (1.6); 7.7956 (1.4); 7.7743 (1.3); 7.0636 (2.7); 6.7946 (2.8); 6.0952 (3.4); 3.3197 (16.0); 2.5405 (0.7); 2.5237 (0.8); 2.5191 (1.1); 2.5103 (16.1); 2.5058 (35.0); 2.5012 (48.8); 2.4966 (33.5); 2.4920 (14.6); 1.9886 (1.8); 1.4187 (1.6); 1.4017 (1.6); 1.1922 (0.5); 1.1744 (1.1); 1.1566 (0.5); 0.0080 (0.9); -0.0002 (29.8); -0.0085 (0.8) I.1-133: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6384 (0.7); 8.6324 (0.9); 8.5926 (0.8); 8.5866 (0.7); 8.2373 (1.0); 8.2164 (1.0); 8.0892 (0.6); 8.0423 (1.3); 7.7648 (1.1); 7.7432 (2.0); 7.5443 (0.6); 7.2605 (31.8); 3.9742 (4.5); 1.5468 (16.0); 1.4355 (1.6); 1.4187 (1.6); 0.0079 (1.0); -0.0002 (30.4); -0.0085 (1.0) I.1-134: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8376 (1.0); 8.8362 (1.0); 8.6885 (0.5); 8.6824 (0.8); 8.6601 (0.9); 8.6540 (0.7); 8.0853 (0.7); 8.0641 (0.9); 7.9162 (1.0); 7.9149 (0.9); 7.8279 (0.8); 7.8067 (0.7); 3.3190 (16.0); 2.5406 (0.7); 2.5238 (0.7); 2.5191 (1.0); 2.5104 (17.2); 2.5058 (37.9); 2.5012 (53.2); 2.4966 (36.6); 2.4920 (16.1); 1.4869 (0.8); 1.4697 (0.8); 0.0080 (1.1); -0.0002 (38.0); -0.0085 (1.1) I.1-135: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6641 (2.6); 8.6580 (3.2); 8.6045 (2.4); 8.5984 (2.0); 8.2412 (3.1); 8.2364 (1.0); 8.2247 (1.1); 8.2198 (3.4); 8.1986 (1.2); 8.1949 (2.4); 8.1912 (1.3); 7.9854 (1.2); 7.8880 (1.2); 7.7395 (3.3); 7.7347 (1.0); 7.7229 (1.0); 7.7181 (3.0); 7.5188 (0.8); 7.4482 (0.5); 7.4296 (0.6); 7.2603 (139.1); 6.9967 (0.8); 5.6946 (0.6); 5.6774 (0.7); 5.6587 (0.5); 3.9772 (15.9); 3.2139 (0.9); 3.1952 (2.9); 3.1767 (3.1); 3.1581 (0.9); 2.0455 (0.7); 1.5438 (16.0); 1.4400 (4.7); 1.4233 (4.6); 1.3473 (3.3); 1.3288 (7.3); 1.3101 (3.2); 1.2597 (0.6); 0.1458 (0.6); 0.0120 (1.0); 0.0080 (6.6); 0.0064 (2.5); 0.0048 (4.0); -0.0002 (218.7); -0.0059 (1.3); -0.0067 (1.6); -0.0085 (6.0); -0.0260 (0.5); -0.1492 (0.6) BCS241005-Ausland STR 137 I.1-136: 1H-NMR(600.3 MHz, MeOD): δ= 8.6713 (4.6); 8.6672 (5.3); 8.6074 (5.5); 8.6032 (5.0); 8.3861 (8.3); 8.1921 (6.4); 8.1783 (7.1); 8.1342 (3.6); 7.8141 (6.9); 7.8003 (6.4); 7.3032 (4.8); 7.2928 (5.1); 7.2892 (5.6); 7.2788 (5.2); 7.1670 (6.6); 7.1626 (7.0); 7.1525 (6.7); 7.1480 (7.0); 6.9832 (3.8); 6.9787 (3.7); 6.9691 (7.1); 6.9647 (6.9); 6.9551 (3.5); 6.9507 (3.4); 5.5265 (0.8); 5.5150 (2.5); 5.5034 (2.6); 5.4919 (0.8); 4.8503 (7.2); 3.3666 (0.9); 3.3332 (4.5); 3.3305 (8.9); 3.3278 (12.8); 3.3251 (9.1); 3.3224 (4.7); 2.3608 (0.3); 2.3360 (50.0); 2.3210 (0.4); 2.0058 (0.6); 1.5554 (10.7); 1.5438 (10.8) I.1-137: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7698 (0.5); 8.7588 (1.6); 8.7526 (2.4); 8.7131 (2.4); 8.7070 (1.9); 8.1742 (0.8); 8.1555 (0.9); 8.1114 (2.1); 8.1066 (0.7); 8.0949 (0.7); 8.0900 (2.5); 7.8961 (0.6); 7.8918 (0.6); 7.8733 (0.5); 7.7963 (2.4); 7.7914 (0.7); 7.7798 (0.7); 7.7750 (2.1); 7.4453 (0.5); 7.4411 (0.5); 7.4247 (0.5); 7.4206 (0.5); 5.7576 (1.3); 5.3544 (0.6); 3.9081 (9.3); 3.3201 (16.0); 2.5415 (0.6); 2.5248 (0.6); 2.5201 (0.9); 2.5113 (12.8); 2.5068 (27.7); 2.5022 (38.6); 2.4976 (26.4); 2.4930 (11.5); 1.4415 (2.7); 1.4246 (2.7); 0.0080 (0.5); -0.0002 (19.4); -0.0085 (0.5) I.1-139: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7716 (1.5); 8.7549 (5.5); 8.7489 (6.4); 8.7125 (6.8); 8.7064 (5.4); 8.1974 (1.0); 8.1772 (2.2); 8.1585 (2.5); 8.1382 (1.1); 8.0998 (0.8); 8.0955 (5.9); 8.0909 (1.8); 8.0791 (2.0); 8.0743 (6.8); 8.0702 (0.9); 7.9054 (1.6); 7.9010 (1.6); 7.8884 (1.4); 7.8869 (1.4); 7.8825 (1.5); 7.7751 (1.0); 7.7710 (6.5); 7.7662 (1.9); 7.7545 (1.8); 7.7498 (5.7); 7.7456 (0.8); 7.4475 (1.6); 7.4432 (1.6); 7.4269 (1.5); 7.4228 (1.5); 5.3826 (1.2); 5.3648 (1.6); 5.3470 (1.2); 4.0385 (1.2); 4.0207 (1.2); 3.3222 (16.0); 2.6715 (0.6); 2.5420 (1.6); 2.5349 (0.6); 2.5300 (0.8); 2.5253 (1.9); 2.5206 (2.4); 2.5118 (31.0); 2.5073 (67.2); 2.5027 (93.5); 2.4981 (63.9); 2.4935 (27.7); 2.3298 (0.5); 1.9895 (5.6); 1.9099 (2.3); 1.4413 (7.6); 1.4244 (7.6); 1.3556 (0.8); 1.1929 (1.6); 1.1813 (0.6); 1.1751 (3.3); 1.1573 (1.6); 0.0080 (0.9); -0.0002 (31.2); -0.0086 (0.8) I.1-140: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1108 (3.2); 9.1723 (4.3); 9.1559 (4.5); 8.7658 (7.7); 8.7603 (7.7); 8.6901 (7.7); 8.6840 (11.8); 8.6655 (12.4); 8.6594 (8.3); 8.2067 (4.8); 8.2005 (4.8); 8.1859 (5.3); 8.1796 (5.2); 8.0737 (11.2); 8.0529 (13.5); 7.7978 (13.0); 7.7771 (11.3); 7.6103 (7.7); 7.5894 (7.3); 5.3568 (0.6); 5.3398 (2.7); 5.3229 (4.2); 5.3059 (2.8); 5.2891 (0.6); 3.4094 (0.6); 3.3919 (1.8); 3.3745 (1.9); 3.3570 (0.9); 3.3290 (11.5); 2.6733 (0.5); 2.5440 (1.0); 2.5132 (33.8); 2.5091 (66.7); 2.5047 (88.6); 2.5003 (64.3); 2.3317 (0.5); 1.9904 (0.8); 1.4748 (16.0); 1.4577 (16.0); 1.1088 (1.8); 1.0913 (3.6); 1.0739 (1.8); -0.0002 (15.3); -0.0084 (0.7) BCS241005-Ausland STR 138 I.1-142: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6502 (2.6); 8.6441 (3.2); 8.6030 (2.7); 8.5969 (2.1); 8.2307 (3.2); 8.2259 (1.0); 8.2142 (1.1); 8.2094 (3.4); 8.2051 (0.5); 7.8609 (5.9); 7.8566 (6.7); 7.8003 (1.8); 7.7960 (2.9); 7.7916 (1.4); 7.7398 (0.6); 7.7356 (3.4); 7.7308 (1.0); 7.7191 (1.0); 7.7143 (3.0); 7.2715 (0.6); 7.2619 (10.0); 5.6539 (0.6); 5.6370 (0.7); 5.6346 (0.7); 5.6176 (0.6); 3.9729 (16.0); 1.4103 (5.1); 1.3936 (5.1); -0.0002 (12.4) I.1-143: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1302 (1.1); 9.1139 (1.1); 8.6857 (2.1); 8.6796 (3.1); 8.6602 (3.4); 8.6542 (2.3); 8.0717 (3.0); 8.0507 (3.6); 8.0025 (1.2); 7.9982 (2.5); 7.9939 (2.2); 7.9777 (6.8); 7.9734 (4.7); 7.7849 (3.4); 7.7639 (3.0); 5.3081 (0.7); 5.2913 (1.0); 5.2742 (0.7); 3.3279 (16.0); 2.5263 (0.7); 2.5129 (12.7); 2.5085 (25.9); 2.5040 (34.8); 2.4995 (24.7); 2.4951 (11.5); 1.4650 (3.9); 1.4478 (3.9); 0.0079 (0.6); -0.0002 (15.1); -0.0085 (0.6) I.1-144: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6470 (2.5); 8.6409 (3.1); 8.5911 (2.5); 8.5850 (2.0); 8.2299 (3.0); 8.2251 (1.0); 8.2134 (1.0); 8.2086 (3.4); 7.9070 (2.3); 7.9019 (2.4); 7.7467 (0.5); 7.7425 (3.2); 7.7377 (1.0); 7.7260 (1.0); 7.7212 (3.0); 7.6513 (1.2); 7.6461 (1.1); 7.6305 (1.6); 7.6253 (1.6); 7.5302 (2.8); 7.5094 (2.0); 7.2619 (14.3); 5.6709 (0.6); 5.6539 (0.7); 5.6515 (0.7); 5.6345 (0.6); 3.9721 (16.0); 1.4100 (5.0); 1.3933 (5.0); -0.0002 (13.0) I.1-145: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6490 (2.6); 8.6429 (3.2); 8.5917 (2.6); 8.5856 (2.1); 8.2302 (3.1); 8.2254 (1.0); 8.2137 (1.1); 8.2089 (3.4); 8.2047 (0.5); 7.9083 (2.5); 7.9031 (2.5); 7.7482 (0.6); 7.7439 (3.3); 7.7392 (1.0); 7.7274 (1.0); 7.7227 (3.0); 7.6523 (1.2); 7.6471 (1.2); 7.6315 (1.7); 7.6263 (1.6); 7.5296 (2.9); 7.5088 (2.1); 7.3450 (0.5); 7.3256 (0.5); 7.2619 (13.4); 5.6712 (0.7); 5.6542 (0.8); 5.6520 (0.7); 5.6349 (0.6); 3.9720 (16.0); 1.4119 (5.2); 1.3951 (5.2); -0.0002 (13.0) I.1-146: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6437 (2.5); 8.6376 (3.2); 8.5897 (2.6); 8.5836 (2.1); 8.2289 (3.1); 8.2242 (1.0); 8.2124 (1.0); 8.2076 (3.4); 8.2034 (0.5); 8.0563 (2.4); 8.0512 (2.5); 7.7454 (0.5); 7.7412 (3.3); 7.7364 (1.1); 7.7246 (1.0); 7.7199 (3.1); 7.7031 (2.0); 7.6824 (3.0); 7.6007 (1.7); 7.5954 (1.6); 7.5799 (1.1); 7.5747 (1.1); 7.3105 (0.5); 7.2906 (0.5); 7.2626 (16.1); 5.6650 (0.6); 5.6481 (0.7); 5.6457 (0.7); 5.6288 (0.6); 3.9717 (16.0); 1.5987 (2.0); 1.4079 (5.1); 1.3911 (5.0); -0.0002 (9.3) I.1-147: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6332 (1.7); 8.6271 (2.1); 8.5811 (1.7); 8.5750 (1.3); 8.2276 (2.1); 8.2228 (0.7); 8.2063 (2.2); 7.8119 (2.0); 7.8072 (0.6); 7.7954 (0.7); 7.7905 (2.1); 7.7570 (2.2); 7.7522 (0.7); 7.7357 (2.0); 7.5186 (0.7); 7.3596 (2.2); 7.3381 (2.0); 7.2602 (128.8); 6.9966 (0.7); 5.3001 (0.9); 3.9706 (10.6); 1.8228 (0.6); 1.8097 (1.6); 1.8035 (1.7); 1.7912 (0.6); 1.5405 (16.0); 1.4784 (0.7); 1.4649 (1.7); 1.4587 (1.7); 1.4458 (0.5); 1.4109 (3.3); 1.3942 (3.4); 0.1459 (0.6); 0.0079 (4.9); -0.0002 (158.0); -0.0085 (4.2); -0.1494 (0.6) BCS241005-Ausland STR 139 I.1-148: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6353 (1.5); 8.6292 (1.9); 8.5913 (1.6); 8.5852 (1.2); 8.2324 (1.8); 8.2277 (0.6); 8.2159 (0.6); 8.2111 (2.0); 7.7610 (2.0); 7.7561 (0.6); 7.7444 (0.6); 7.7397 (1.8); 7.6915 (0.5); 7.6803 (0.6); 7.6755 (1.9); 7.6715 (2.0); 7.5394 (0.6); 7.5354 (0.8); 7.4601 (0.8); 7.4398 (0.9); 7.2606 (27.6); 3.9718 (9.4); 1.7833 (0.7); 1.7708 (1.5); 1.7644 (1.6); 1.7522 (0.8); 1.5506 (16.0); 1.4704 (1.5); 1.4635 (1.3); 1.4200 (3.0); 1.4033 (3.0); 0.0079 (1.0); -0.0002 (33.9); -0.0085 (0.9) I.1-149: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6439 (2.6); 8.6378 (3.2); 8.5901 (2.6); 8.5840 (2.1); 8.2333 (0.5); 8.2291 (3.2); 8.2244 (1.0); 8.2126 (1.1); 8.2078 (3.3); 8.2036 (0.5); 8.0564 (2.6); 8.0513 (2.6); 7.7450 (0.6); 7.7408 (3.5); 7.7360 (1.0); 7.7242 (1.1); 7.7195 (3.0); 7.7040 (2.1); 7.6833 (3.0); 7.6008 (1.7); 7.5955 (1.6); 7.5800 (1.2); 7.5748 (1.2); 7.3073 (0.5); 7.2875 (0.5); 7.2620 (12.4); 5.6653 (0.6); 5.6482 (0.8); 5.6460 (0.7); 5.6289 (0.6); 3.9719 (16.0); 1.5827 (5.1); 1.4078 (5.2); 1.3911 (5.1); -0.0002 (13.2) I.1-150: 1H-NMR(400.6 MHz, CDCl3): δ= 8.9334 (2.4); 8.9286 (2.4); 8.7990 (2.1); 8.7934 (2.1); 8.6582 (2.7); 8.6522 (3.2); 8.5961 (2.7); 8.5901 (2.2); 8.2795 (1.8); 8.2744 (2.9); 8.2691 (1.7); 8.2397 (0.5); 8.2354 (3.3); 8.2308 (1.0); 8.2190 (1.1); 8.2143 (3.4); 7.7440 (0.6); 7.7399 (3.9); 7.7350 (1.1); 7.7233 (1.2); 7.7185 (3.4); 7.2692 (3.6); 5.6899 (0.7); 5.6727 (0.8); 5.6538 (0.7); 3.9753 (16.0); 2.0455 (0.6); 1.4239 (5.8); 1.4072 (5.8); -0.0002 (3.2) I.1-151: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1981 (1.6); 9.1827 (1.6); 8.8774 (3.0); 8.8269 (2.7); 8.8229 (2.6); 8.6880 (3.2); 8.6679 (3.2); 8.3843 (2.8); 8.0723 (3.4); 8.0522 (3.8); 7.7909 (3.8); 7.7710 (3.4); 5.3374 (1.0); 5.3208 (1.4); 5.3039 (1.0); 3.3297 (16.0); 2.5039 (49.6); 1.4791 (5.2); 1.4623 (5.2); - 0.0002 (11.1) I.1-152: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6577 (2.5); 8.6516 (3.1); 8.6063 (2.7); 8.6002 (2.2); 8.2356 (3.2); 8.2309 (1.0); 8.2191 (1.1); 8.2144 (3.5); 8.2102 (0.5); 7.8582 (1.4); 7.8543 (2.6); 7.8504 (1.4); 7.7420 (0.6); 7.7377 (3.4); 7.7330 (1.1); 7.7212 (1.0); 7.7165 (3.2); 7.6103 (1.4); 7.5272 (1.3); 7.3365 (0.6); 7.3164 (0.6); 7.2621 (30.2); 5.6673 (0.7); 5.6483 (0.8); 5.6311 (0.7); 3.9752 (16.0); 1.5663 (14.7); 1.4171 (5.2); 1.4004 (5.2); 0.0079 (1.2); -0.0002 (39.8); -0.0084 (1.1) I.1-153: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6573 (2.3); 8.6512 (2.8); 8.6008 (2.4); 8.5947 (2.0); 8.2358 (2.9); 8.2312 (0.9); 8.2193 (1.0); 8.2146 (3.2); 7.7380 (3.1); 7.7333 (1.0); 7.7215 (1.0); 7.7168 (2.9); 7.4764 (1.9); 7.4711 (2.2); 7.4583 (0.7); 7.4527 (0.8); 7.4490 (0.5); 7.3458 (0.5); 7.2621 (30.2); 7.1244 (0.6); 7.1219 (0.6); 7.1028 (0.6); 5.6738 (0.6); 5.6567 (0.7); 5.6375 (0.6); 3.9756 (14.7); 1.5641 (16.0); 1.4136 (4.9); 1.3969 (4.9); 0.0080 (1.2); -0.0002 (40.0); -0.0085 (1.1) BCS241005-Ausland STR 140 I.1-154: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9652 (0.7); 8.9486 (0.7); 8.6760 (1.5); 8.6699 (2.5); 8.6535 (2.9); 8.6474 (1.9); 8.0766 (2.2); 8.0720 (0.7); 8.0602 (0.8); 8.0554 (2.6); 7.8169 (2.5); 7.8122 (0.7); 7.8004 (0.7); 7.7957 (2.1); 7.7582 (0.7); 7.7544 (0.5); 7.7427 (0.5); 7.7390 (0.8); 7.7355 (0.6); 7.6770 (0.8); 7.6729 (1.3); 7.6688 (0.7); 7.4930 (0.7); 7.4898 (0.8); 7.4882 (0.9); 7.4850 (0.6); 7.4588 (1.0); 7.4396 (1.3); 5.7568 (1.2); 5.3214 (0.7); 3.3268 (16.0); 2.5249 (0.6); 2.5202 (0.8); 2.5115 (11.6); 2.5070 (25.4); 2.5024 (35.3); 2.4978 (24.1); 2.4932 (10.5); 1.7842 (0.7); 1.7723 (1.6); 1.7649 (2.0); 1.7535 (0.9); 1.5672 (0.6); 1.5645 (0.5); 1.5541 (1.8); 1.5472 (1.8); 1.4665 (2.6); 1.4493 (2.6); 1.3557 (0.7); 0.0080 (0.6); -0.0002 (24.4); -0.0085 (0.6) I.1-155: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1896 (0.5); 9.1733 (0.6); 8.6877 (1.2); 8.6816 (2.0); 8.6634 (2.2); 8.6574 (1.5); 8.0870 (0.8); 8.0831 (1.4); 8.0792 (0.9); 8.0639 (1.8); 8.0594 (0.6); 8.0475 (0.6); 8.0428 (2.1); 7.8539 (0.8); 7.7825 (2.0); 7.7778 (0.6); 7.7660 (0.6); 7.7613 (1.7); 7.7437 (0.7); 7.7409 (0.8); 7.7382 (0.7); 5.3101 (0.6); 3.3208 (16.0); 2.5245 (0.8); 2.5198 (1.1); 2.5111 (17.8); 2.5065 (38.7); 2.5019 (53.8); 2.4974 (36.8); 2.4928 (16.1); 1.9890 (1.4); 1.4759 (2.1); 1.4587 (2.1); 1.1748 (0.8); 0.0080 (0.7); -0.0002 (24.1); -0.0085 (0.6) I.1-156: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1415 (2.1); 9.1251 (2.1); 8.6866 (4.7); 8.6805 (7.7); 8.6634 (8.6); 8.6574 (5.5); 8.0632 (6.8); 8.0586 (2.1); 8.0468 (2.4); 8.0421 (8.0); 8.0379 (1.1); 7.7846 (7.6); 7.7799 (2.3); 7.7681 (2.2); 7.7635 (6.5); 7.7420 (1.4); 7.7386 (1.6); 7.7363 (1.6); 7.7328 (1.4); 7.7188 (1.4); 7.7154 (1.7); 7.7130 (1.5); 7.7096 (1.4); 7.6409 (2.8); 7.5972 (1.4); 7.5769 (1.4); 5.3326 (1.4); 5.3157 (2.1); 5.2988 (1.4); 3.3228 (14.4); 2.6715 (0.7); 2.5420 (0.5); 2.5348 (0.6); 2.5302 (0.8); 2.5253 (2.2); 2.5206 (2.9); 2.5118 (38.3); 2.5073 (82.0); 2.5027 (113.2); 2.4981 (77.1); 2.4936 (33.3); 2.3298 (0.7); 2.0865 (16.0); 1.9890 (0.6); 1.9098 (0.9); 1.4785 (8.3); 1.4612 (8.3); 1.3559 (1.7); 1.1815 (0.7); 1.1412 (1.0); 0.0080 (1.5); -0.0002 (52.4); -0.0086 (1.4) I.1-157: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6670 (2.5); 8.6610 (3.1); 8.6110 (2.7); 8.6049 (2.2); 8.2491 (3.8); 8.2451 (5.0); 8.2402 (1.2); 8.2283 (1.1); 8.2236 (3.5); 8.2195 (0.6); 8.0189 (1.4); 7.7528 (0.6); 7.7486 (3.4); 7.7439 (1.1); 7.7321 (1.0); 7.7274 (3.1); 7.7232 (0.5); 7.4575 (0.6); 7.4376 (0.6); 7.2614 (15.5); 5.7124 (0.7); 5.6953 (0.8); 5.6763 (0.7); 3.9778 (16.0); 1.5744 (13.2); 1.4517 (5.3); 1.4350 (5.3); 0.0080 (0.6); -0.0002 (18.5); -0.0085 (0.5) I.1-158: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7064 (8.2); 8.7003 (9.8); 8.6340 (8.4); 8.6279 (7.4); 8.2961 (16.0); 8.2922 (14.2); 8.2802 (3.6); 8.2756 (10.6); 8.0246 (4.9); 7.7976 (10.2); 7.7931 (3.3); 7.7810 (3.2); 7.7765 (9.4); 7.7349 (2.4); 7.7156 (2.4); 7.5192 (0.5); 7.2607 (94.5); 5.7605 (2.0); 5.7432 (2.6); 5.7245 (2.0); 5.3001 (2.3); 1.5186 (14.6); 1.5018 (14.5); 0.0080 (3.3); -0.0002 (112.7); -0.0085 (3.3) BCS241005-Ausland STR 141 I.1-159: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6901 (0.7); 8.6840 (1.0); 8.6632 (1.2); 8.6571 (0.8); 8.0843 (1.0); 8.0629 (1.1); 7.8209 (1.1); 7.7995 (0.9); 7.5904 (0.7); 3.8957 (4.2); 3.3201 (16.0); 2.5195 (0.5); 2.5108 (8.5); 2.5062 (18.6); 2.5016 (26.1); 2.4970 (17.8); 2.4924 (7.8); 1.9888 (0.8); 1.8024 (0.7); 1.7948 (0.7); 1.6031 (0.7); 1.5959 (0.7); 1.4756 (1.1); 1.4584 (1.1); -0.0002 (14.9) I.1-160: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6481 (4.0); 8.6421 (5.4); 8.5983 (4.5); 8.5920 (3.9); 8.2529 (5.2); 8.2319 (5.8); 7.8298 (4.9); 7.8084 (5.7); 7.7802 (5.7); 7.7593 (5.1); 7.5187 (4.4); 7.3665 (5.9); 7.3451 (5.1); 7.2601 (783.9); 6.9965 (4.2); 5.7111 (1.7); 3.9675 (1.7); 3.6253 (3.2); 2.1111 (1.6); 1.8272 (1.7); 1.8136 (4.3); 1.8073 (4.1); 1.7952 (1.9); 1.5434 (16.0); 1.4830 (3.8); 1.4689 (5.5); 1.4628 (5.8); 1.4482 (10.3); 1.4314 (9.2); 1.2547 (2.5); 0.1459 (4.0); 0.0080 (29.8); -0.0002 (964.4); -0.0085 (27.7); - 0.1494 (3.7) I.1-161: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6759 (0.5); 8.6591 (0.6); 8.0471 (0.6); 7.7980 (0.5); 3.3202 (16.0); 2.5192 (0.7); 2.5104 (10.2); 2.5059 (22.2); 2.5013 (30.9); 2.4967 (21.1); 2.4921 (9.2); 1.9886 (1.4); 1.4726 (0.6); 1.4554 (0.6); 1.1745 (0.8); -0.0002 (15.0) I.1-163: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6867 (0.6); 8.6806 (1.0); 8.6645 (1.2); 8.6584 (0.8); 8.0612 (0.9); 8.0400 (1.1); 7.7926 (1.0); 7.7714 (0.9); 7.7588 (0.7); 3.3214 (16.0); 2.5410 (0.6); 2.5242 (0.7); 2.5195 (0.9); 2.5108 (12.8); 2.5062 (27.7); 2.5016 (38.4); 2.4970 (26.1); 2.4924 (11.3); 1.8301 (0.5); 1.8218 (0.7); 1.6410 (0.7); 1.6331 (0.5); 1.4859 (1.0); 1.4686 (1.0); -0.0002 (14.9) I.1-164: 1H-NMR(400.6 MHz, CDCl3): δ= 9.1222 (5.4); 8.6486 (2.5); 8.6425 (3.2); 8.6062 (2.7); 8.6001 (2.0); 8.5058 (1.8); 8.5025 (1.8); 8.2462 (0.5); 8.2419 (3.0); 8.2371 (1.0); 8.2254 (1.1); 8.2206 (3.4); 8.2162 (0.6); 8.1997 (1.6); 8.1785 (1.9); 7.9494 (1.5); 7.9450 (1.4); 7.9280 (1.2); 7.9236 (1.2); 7.7750 (3.2); 7.7702 (1.0); 7.7585 (1.0); 7.7537 (2.9); 7.4622 (0.5); 7.4428 (0.5); 7.2604 (71.7); 5.7483 (0.6); 5.7312 (0.7); 5.7117 (0.6); 4.1311 (1.1); 4.1132 (1.1); 3.9765 (16.0); 2.0455 (5.3); 1.5466 (4.6); 1.4482 (5.0); 1.4315 (4.9); 1.2774 (1.5); 1.2596 (3.1); 1.2418 (1.4); 0.0079 (2.6); -0.0002 (89.9); -0.0085 (2.4) I.1-165: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6991 (0.5); 8.6929 (0.8); 8.6702 (0.9); 8.6642 (0.6); 8.1603 (0.7); 8.0983 (0.5); 8.0733 (0.7); 8.0522 (0.9); 7.7937 (0.8); 7.7726 (0.7); 3.8986 (3.1); 3.3203 (16.0); 2.5108 (7.5); 2.5062 (16.2); 2.5017 (22.5); 2.4971 (15.5); 2.4925 (6.8); 1.4876 (0.9); 1.4704 (0.9); -0.0002 (9.6) BCS241005-Ausland STR 142 I.1-166: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.5830 (1.0); 9.5228 (16.0); 9.0118 (2.3); 8.9955 (2.4); 8.6832 (5.4); 8.6771 (8.2); 8.6576 (9.6); 8.6515 (6.5); 8.6150 (4.7); 8.6116 (4.6); 8.1563 (0.5); 8.1130 (4.1); 8.0917 (6.1); 8.0850 (7.5); 8.0804 (2.4); 8.0685 (2.7); 8.0638 (9.1); 7.9767 (4.1); 7.9723 (3.9); 7.9553 (3.1); 7.9509 (3.1); 7.8324 (8.4); 7.8276 (2.4); 7.8159 (2.4); 7.8112 (7.3); 5.3628 (1.5); 5.3460 (2.3); 5.3291 (1.5); 4.1290 (1.9); 3.5421 (2.4); 3.5153 (2.3); 3.5087 (0.7); 3.1676 (0.8); 2.6799 (0.9); 2.6753 (2.1); 2.6707 (2.9); 2.6661 (2.1); 2.5443 (0.9); 2.5412 (3.5); 2.5355 (1.9); 2.5309 (1.8); 2.5245 (7.1); 2.5198 (10.3); 2.5111 (166.8); 2.5065 (365.9); 2.5019 (511.8); 2.4973 (350.3); 2.4928 (153.8); 2.4792 (1.8); 2.4749 (1.3); 2.4705 (0.9); 2.4613 (0.6); 2.4520 (0.8); 2.3381 (0.9); 2.3336 (2.1); 2.3290 (2.9); 2.3243 (2.0); 2.3195 (0.8); 1.4863 (10.1); 1.4690 (9.6); 1.2585 (0.7); 1.2343 (1.5); 0.9565 (1.0); 0.9482 (1.0); 0.9422 (2.6); 0.9389 (2.0); 0.9244 (1.2); 0.1456 (0.8); 0.0375 (0.6); 0.0080 (7.2); -0.0002 (287.2); -0.0085 (8.0); -0.0243 (0.5); -0.0277 (0.6); -0.0315 (0.8); -0.1493 (0.8) I.1-167: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6499 (1.0); 8.6438 (1.2); 8.6210 (1.7); 8.5993 (1.0); 8.5932 (0.8); 8.2399 (1.2); 8.2185 (1.4); 8.1309 (1.8); 7.8117 (0.5); 7.8070 (0.8); 7.8031 (0.6); 7.7587 (1.3); 7.7374 (1.2); 7.7107 (0.5); 7.7061 (1.0); 7.7014 (0.6); 7.6578 (0.6); 7.6539 (0.9); 7.6499 (0.5); 7.2604 (55.7); 4.1310 (0.6); 4.1132 (0.6); 3.9747 (6.2); 2.5940 (6.2); 2.0455 (2.6); 1.5438 (16.0); 1.4378 (1.9); 1.4210 (1.9); 1.2775 (0.8); 1.2597 (1.6); 1.2418 (0.7); 0.0080 (2.2); -0.0002 (69.2); -0.0085 (2.1) I.1-168: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6401 (1.6); 8.6340 (2.0); 8.5948 (1.8); 8.5887 (1.4); 8.3668 (1.3); 8.2354 (2.1); 8.2308 (0.7); 8.2189 (0.8); 8.2143 (2.2); 7.8819 (2.0); 7.8719 (1.5); 7.8680 (1.4); 7.7697 (2.3); 7.7650 (0.7); 7.7531 (0.7); 7.7486 (1.9); 7.2605 (45.7); 5.7228 (0.5); 4.1311 (0.6); 4.1133 (0.6); 3.9739 (10.1); 2.8702 (9.9); 2.0455 (2.9); 1.5462 (16.0); 1.4313 (3.4); 1.4147 (3.4); 1.2775 (0.8); 1.2596 (1.7); 1.2418 (0.8); 0.0079 (1.7); -0.0002 (54.5); -0.0085 (1.6) I.1-170: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6424 (1.6); 8.6363 (2.4); 8.6126 (2.0); 8.6065 (1.4); 8.3385 (1.2); 8.2451 (2.2); 8.2405 (0.7); 8.2286 (0.8); 8.2240 (2.4); 7.9568 (0.6); 7.9387 (0.6); 7.9336 (0.6); 7.9182 (0.5); 7.8966 (1.6); 7.8854 (0.6); 7.8790 (1.4); 7.8747 (1.5); 7.8677 (0.7); 7.7975 (2.4); 7.7929 (0.8); 7.7810 (0.7); 7.7764 (2.2); 7.5773 (0.8); 7.5732 (0.7); 7.5656 (0.8); 7.5597 (1.6); 7.5536 (0.7); 7.5462 (0.6); 7.5422 (0.7); 7.2603 (40.6); 5.7564 (0.6); 3.9754 (10.8); 2.0455 (0.6); 1.5465 (16.0); 1.4671 (3.7); 1.4503 (3.7); 0.0079 (1.6); -0.0002 (48.5); -0.0085 (1.5) BCS241005-Ausland STR 143 I.1-171: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6493 (2.5); 8.6432 (3.3); 8.5987 (2.9); 8.5926 (2.4); 8.3672 (2.2); 8.3635 (2.3); 8.2374 (3.3); 8.2329 (1.2); 8.2209 (1.2); 8.2164 (3.7); 7.9438 (1.1); 7.9396 (1.0); 7.9228 (1.8); 7.9186 (1.8); 7.8667 (2.8); 7.8457 (1.6); 7.7644 (3.7); 7.7600 (1.2); 7.7479 (1.1); 7.7435 (3.3); 7.5233 (0.7); 7.5039 (0.7); 7.2609 (36.9); 5.7345 (0.7); 5.7156 (0.9); 5.6981 (0.7); 4.1311 (0.7); 4.1132 (0.7); 3.9753 (16.0); 2.0456 (3.2); 1.5543 (5.3); 1.4348 (5.7); 1.4182 (5.7); 1.2774 (1.0); 1.2596 (2.0); 1.2418 (0.9); 0.0079 (1.4); -0.0002 (43.0); -0.0084 (1.5) I.1-174: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6487 (2.5); 8.6439 (3.0); 8.5918 (3.0); 8.5862 (2.6); 8.2515 (3.8); 8.2315 (4.2); 7.9090 (2.7); 7.9049 (2.8); 7.7423 (4.1); 7.7222 (3.9); 7.6526 (1.3); 7.6492 (1.2); 7.6319 (1.7); 7.6280 (1.8); 7.5346 (2.9); 7.5134 (2.2); 7.3212 (1.1); 7.3010 (1.2); 7.2625 (21.6); 7.2609 (22.3); 5.6739 (1.0); 5.6562 (1.3); 5.6391 (1.0); 4.5541 (2.2); 4.5425 (3.0); 4.5302 (2.5); 3.8893 (2.4); 3.8766 (3.2); 3.8654 (2.4); 3.7414 (2.2); 3.7321 (3.2); 3.7190 (3.2); 3.6082 (3.1); 3.5953 (3.3); 3.5851 (2.3); 3.4064 (15.8); 3.4049 (16.0); 2.0459 (0.8); 1.5765 (2.5); 1.4082 (6.3); 1.3916 (6.3); 1.2597 (1.1); 1.2434 (0.5); 0.0015 (31.4); -0.0002 (32.4) I.1-175: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6577 (5.6); 8.6348 (5.7); 8.3754 (5.9); 8.2701 (6.2); 8.2496 (7.4); 7.9675 (2.5); 7.9478 (3.0); 7.9092 (6.6); 7.8973 (6.9); 7.8744 (4.2); 7.8106 (6.9); 7.7905 (7.0); 7.5817 (3.4); 7.5661 (5.0); 7.5492 (2.9); 7.2909 (1.6); 7.2600 (205.0); 7.2577 (186.6); 5.8333 (1.7); 5.8152 (2.6); 5.7961 (1.6); 3.4933 (4.3); 1.5225 (16.0); 1.5058 (14.9); 1.2525 (1.9); 0.1457 (1.8); 0.0289 (3.4); -0.0002 (304.3); -0.0025 (269.4); -0.1496 (1.7) I.1-176: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6578 (2.7); 8.6517 (3.2); 8.6158 (3.2); 8.6101 (2.6); 8.2539 (3.8); 8.2336 (4.1); 8.1452 (3.1); 7.8053 (1.3); 7.7806 (4.6); 7.7601 (3.8); 7.7270 (3.0); 7.7063 (2.0); 7.5897 (1.2); 7.5698 (1.4); 7.5197 (0.5); 7.2605 (94.6); 6.9981 (0.6); 5.7980 (0.9); 5.7793 (1.2); 5.7627 (1.0); 4.2388 (16.0); 3.4951 (0.6); 1.5791 (1.8); 1.4821 (6.9); 1.4654 (6.9); 1.2567 (0.7); 0.1465 (0.5); - 0.0002 (120.9); -0.1490 (0.7) I.1-178: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6458 (2.5); 8.6397 (3.1); 8.5920 (2.7); 8.5860 (2.2); 8.2301 (3.1); 8.2256 (1.1); 8.2137 (1.1); 8.2090 (3.6); 8.0676 (2.5); 8.0625 (2.6); 7.7410 (3.4); 7.7364 (1.1); 7.7245 (1.0); 7.7199 (3.2); 7.6959 (1.2); 7.6907 (1.2); 7.6751 (1.6); 7.6699 (1.5); 7.5307 (2.9); 7.5099 (2.2); 7.2984 (0.6); 7.2797 (0.6); 7.2604 (46.8); 5.6684 (0.7); 5.6497 (0.8); 5.6318 (0.7); 3.9724 (16.0); 1.5484 (5.1); 1.4094 (5.4); 1.3927 (5.4); 1.2648 (0.6); 0.8820 (0.8); 0.0080 (1.8); -0.0002 (67.7); -0.0084 (2.0) BCS241005-Ausland STR 144 I.1-179: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6456 (2.6); 8.6395 (3.1); 8.5905 (2.8); 8.5844 (2.2); 8.2298 (3.2); 8.2252 (1.0); 8.2133 (1.2); 8.2087 (3.4); 7.8961 (2.5); 7.8909 (2.6); 7.7396 (3.6); 7.7349 (1.0); 7.7231 (1.2); 7.7186 (3.1); 7.7088 (2.3); 7.6880 (2.9); 7.5580 (1.6); 7.5527 (1.5); 7.5372 (1.3); 7.5320 (1.2); 7.3154 (0.6); 7.2949 (0.6); 7.2603 (56.6); 5.6688 (0.7); 5.6520 (0.8); 5.6325 (0.7); 3.9725 (16.0); 1.5455 (12.6); 1.4074 (5.5); 1.3907 (5.5); 0.0079 (2.8); -0.0002 (82.1); -0.0085 (2.2) I.1-180: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6880 (0.7); 8.6620 (0.8); 8.6559 (0.6); 8.0978 (0.7); 8.0766 (0.8); 7.9246 (0.5); 7.8602 (0.8); 7.8390 (0.6); 5.7571 (1.2); 3.8900 (2.8); 3.3195 (16.0); 2.5240 (0.7); 2.5193 (0.9); 2.5105 (13.1); 2.5060 (28.2); 2.5014 (39.0); 2.4968 (26.7); 2.4923 (11.7); 1.5030 (0.8); 1.4858 (0.8); 0.0080 (0.6); -0.0002 (20.7); -0.0085 (0.6) I.1-181: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6534 (2.5); 8.6473 (3.3); 8.6123 (2.9); 8.6062 (2.2); 8.3395 (2.0); 8.3353 (2.0); 8.3118 (1.5); 8.2898 (1.7); 8.2476 (3.3); 8.2430 (1.1); 8.2310 (1.2); 8.2264 (3.6); 7.9738 (1.4); 7.9693 (1.3); 7.9517 (1.2); 7.9472 (1.2); 7.9262 (1.3); 7.9055 (1.4); 7.8762 (1.5); 7.8737 (1.5); 7.8576 (1.7); 7.8551 (1.5); 7.7911 (3.6); 7.7865 (1.2); 7.7746 (1.1); 7.7700 (3.3); 7.5087 (0.6); 7.4895 (0.7); 7.4145 (1.4); 7.3947 (1.7); 7.3754 (1.2); 7.2603 (32.5); 5.7713 (0.7); 5.7525 (0.8); 5.7350 (0.7); 3.9774 (16.0); 1.5758 (0.8); 1.4711 (5.5); 1.4543 (5.5); 0.0080 (1.5); -0.0002 (46.8); -0.0084 (1.4) I.1-182: 1H-NMR(400.6 MHz, CDCl3): δ= 9.0869 (4.2); 8.6503 (2.4); 8.6443 (3.1); 8.6064 (2.9); 8.6004 (2.3); 8.5699 (2.4); 8.5667 (2.3); 8.2418 (3.4); 8.2372 (1.3); 8.2252 (1.5); 8.2207 (3.7); 8.0499 (1.5); 8.0291 (2.6); 7.9793 (1.7); 7.9754 (1.6); 7.9583 (1.0); 7.9544 (1.0); 7.7803 (3.7); 7.7757 (1.4); 7.7637 (1.4); 7.7592 (3.4); 7.5558 (0.8); 7.5366 (0.8); 7.2624 (18.9); 5.7570 (0.8); 5.7398 (0.9); 5.7206 (0.8); 3.9758 (16.0); 2.9565 (0.6); 2.8849 (0.6); 2.0453 (0.6); 1.4514 (5.8); 1.4347 (5.8); 1.2591 (1.1); 1.2561 (1.1); 1.2439 (0.5); 0.0079 (0.8); -0.0002 (14.0); -0.0084 (0.6) I.1-183: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6606 (2.6); 8.6546 (3.2); 8.6083 (2.9); 8.6023 (2.4); 8.4616 (4.0); 8.4581 (4.2); 8.2462 (3.3); 8.2416 (1.1); 8.2297 (1.1); 8.2251 (3.7); 8.2051 (1.6); 8.2013 (2.8); 8.1975 (1.4); 8.0797 (2.2); 8.0733 (2.2); 7.7954 (2.2); 7.7912 (2.2); 7.7609 (3.6); 7.7563 (1.1); 7.7444 (1.1); 7.7398 (3.3); 7.5023 (0.7); 7.4819 (0.7); 7.2609 (53.7); 6.5656 (1.6); 6.5611 (1.8); 6.5593 (1.8); 6.5548 (1.6); 5.7189 (0.7); 5.7011 (0.8); 5.6826 (0.7); 4.1310 (1.4); 4.1132 (1.4); 3.9773 (16.0); 3.1523 (15.2); 2.1032 (0.7); 2.0455 (6.4); 1.5747 (2.6); 1.4649 (5.2); 1.4482 (5.3); 1.2843 (0.7); 1.2775 (1.9); 1.2596 (4.3); 1.2418 (1.8); 0.0079 (1.9); -0.0002 (67.6); -0.0085 (1.9) BCS241005-Ausland STR 145 I.1-185: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6810 (8.8); 8.6749 (10.7); 8.6166 (9.3); 8.6105 (7.7); 8.2636 (10.1); 8.2591 (3.4); 8.2471 (3.7); 8.2425 (11.5); 8.1095 (8.7); 8.1043 (8.7); 7.7709 (11.0); 7.7664 (3.4); 7.7544 (3.7); 7.7499 (10.2); 7.7382 (4.4); 7.7330 (4.2); 7.7174 (5.2); 7.7122 (5.0); 7.5561 (2.6); 7.5395 (11.2); 7.5188 (8.2); 7.2611 (48.3); 5.7509 (0.6); 5.7339 (2.2); 5.7151 (2.6); 5.6977 (2.2); 5.6815 (0.5); 4.1502 (0.9); 4.1323 (2.6); 4.1145 (2.7); 4.0967 (0.9); 2.1333 (10.0); 2.0472 (12.2); 1.4796 (16.0); 1.4629 (16.0); 1.4322 (1.8); 1.2780 (3.4); 1.2602 (7.2); 1.2423 (4.4); 1.2225 (0.8); 0.0079 (2.1); -0.0002 (69.0); - 0.0085 (2.0) I.1-187: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6705 (6.5); 8.6644 (9.0); 8.6326 (8.0); 8.6265 (6.2); 8.3468 (5.1); 8.2703 (9.0); 8.2494 (9.8); 8.0544 (5.0); 7.9304 (2.4); 7.9089 (3.8); 7.9049 (3.7); 7.8367 (11.4); 7.8152 (10.0); 7.8017 (9.7); 7.7808 (8.6); 7.6413 (3.8); 7.6370 (4.3); 7.6290 (2.4); 7.6199 (3.5); 7.6153 (3.7); 7.5188 (1.4); 7.2900 (1.3); 7.2604 (262.6); 6.9968 (1.5); 5.8245 (1.8); 5.8068 (2.4); 5.7884 (1.9); 3.4937 (2.8); 1.5182 (16.0); 1.5015 (15.6); 1.2563 (1.6); 0.1587 (1.2); 0.1458 (1.4); 0.0295 (1.3); 0.0080 (10.0); -0.0002 (334.4); -0.0084 (10.0); -0.1494 (1.4) I.1-188: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4724 (0.8); 8.6541 (0.6); 8.0614 (0.5); 3.3942 (0.5); 3.3812 (0.5); 3.3179 (16.0); 2.6744 (0.5); 2.6697 (0.7); 2.6652 (0.5); 2.5235 (1.9); 2.5188 (2.6); 2.5100 (40.1); 2.5055 (87.2); 2.5009 (121.8); 2.4963 (83.7); 2.4918 (36.7); 2.3280 (0.7); 1.4866 (0.6); 1.4694 (0.6); 1.2351 (0.6); 0.0080 (2.5); -0.0002 (91.0); -0.0085 (2.5) I.1-189: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6450 (2.4); 8.6395 (2.9); 8.5889 (3.0); 8.5830 (2.4); 8.2576 (3.7); 8.2374 (4.0); 8.0577 (2.8); 8.0531 (2.8); 7.7418 (4.0); 7.7215 (3.7); 7.7051 (2.1); 7.6844 (3.1); 7.6014 (1.7); 7.5971 (1.6); 7.5808 (1.2); 7.5763 (1.1); 7.3003 (0.9); 7.2800 (1.0); 7.2607 (16.2); 5.6656 (0.9); 5.6479 (1.2); 5.6301 (0.9); 4.5388 (2.0); 4.5293 (2.3); 4.5250 (2.2); 4.5155 (2.1); 3.7752 (2.4); 3.7637 (3.2); 3.7518 (2.2); 3.4587 (16.0); 1.5708 (8.4); 1.4323 (0.5); 1.4018 (6.0); 1.3852 (6.0); 1.2560 (2.0); 0.8822 (0.6); -0.0002 (19.2); -0.0070 (0.8) I.1-190: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6451 (2.2); 8.6390 (2.6); 8.5900 (2.4); 8.5840 (1.9); 8.2500 (2.7); 8.2455 (0.9); 8.2335 (0.9); 8.2290 (2.9); 8.0575 (2.2); 8.0524 (2.2); 7.7404 (3.0); 7.7359 (0.9); 7.7238 (0.9); 7.7194 (2.6); 7.7064 (1.8); 7.6857 (2.6); 7.6014 (1.4); 7.5962 (1.3); 7.5807 (1.0); 7.5755 (1.0); 7.2997 (0.6); 7.2795 (0.6); 7.2608 (26.9); 5.6672 (0.6); 5.6501 (0.7); 5.6310 (0.6); 4.5526 (1.4); 4.5406 (1.6); 4.5283 (1.6); 3.8879 (1.7); 3.8757 (1.8); 3.8637 (1.6); 3.7404 (1.7); 3.7321 (1.5); 3.7293 (2.1); 3.7245 (1.4); 3.7173 (2.5); 3.6068 (2.5); 3.5996 (1.4); 3.5947 (2.0); 3.5919 (1.4); 3.5837 (1.6); 3.4045 (16.0); 1.5536 (4.1); 1.4049 (4.4); 1.3881 (4.4); 0.0079 (1.0); -0.0002 (33.4); -0.0085 (0.9) BCS241005-Ausland STR 146 I.1-191: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6448 (2.5); 8.6387 (3.1); 8.5868 (2.8); 8.5808 (2.3); 8.2262 (3.2); 8.2218 (1.0); 8.2098 (1.1); 8.2052 (3.5); 8.0581 (2.6); 8.0529 (2.6); 7.7258 (3.5); 7.7212 (1.1); 7.7047 (5.2); 7.6839 (3.1); 7.6008 (1.6); 7.5956 (1.6); 7.5801 (1.1); 7.5749 (1.1); 7.2974 (0.6); 7.2780 (0.7); 7.2607 (28.4); 5.6697 (0.7); 5.6524 (0.8); 5.6334 (0.7); 5.3174 (1.0); 5.3018 (1.4); 5.2862 (1.0); 1.5622 (3.7); 1.4149 (15.0); 1.3993 (16.0); 1.3858 (5.4); 0.0079 (1.1); -0.0002 (35.5); -0.0084 (1.0) I.1-192: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6364 (2.6); 8.6304 (3.1); 8.5637 (2.7); 8.5577 (2.3); 8.2347 (3.2); 8.2301 (1.1); 8.2182 (1.1); 8.2135 (3.7); 8.2094 (0.6); 7.7549 (3.5); 7.7502 (1.1); 7.7384 (1.1); 7.7338 (3.3); 7.7296 (0.5); 7.5415 (1.3); 7.5375 (1.5); 7.5215 (1.6); 7.5176 (1.7); 7.4596 (1.4); 7.4557 (1.4); 7.4405 (1.8); 7.4365 (1.5); 7.2757 (1.8); 7.2607 (27.2); 7.2562 (3.0); 7.2365 (1.3); 7.1788 (0.5); 5.6964 (0.7); 5.6796 (0.8); 5.6768 (0.8); 5.6597 (0.7); 3.9736 (16.0); 2.0453 (1.1); 1.5475 (11.2); 1.4429 (5.8); 1.4262 (5.8); 1.2596 (0.7); 0.0079 (1.0); -0.0002 (33.4); -0.0085 (1.0) I.1-193: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6325 (2.6); 8.6264 (3.1); 8.5704 (2.7); 8.5644 (2.2); 8.2332 (0.6); 8.2290 (3.3); 8.2244 (1.2); 8.2125 (1.2); 8.2078 (3.7); 7.7482 (3.6); 7.7437 (1.3); 7.7317 (1.1); 7.7270 (3.3); 7.6324 (2.5); 7.6116 (2.8); 7.4355 (2.6); 7.4306 (2.8); 7.4133 (0.6); 7.3934 (0.6); 7.3196 (1.8); 7.3146 (1.6); 7.2987 (1.6); 7.2938 (1.5); 7.2609 (18.6); 5.6894 (0.8); 5.6700 (0.9); 5.6531 (0.7); 3.9714 (16.0); 2.0452 (0.8); 1.5531 (5.0); 1.4385 (5.8); 1.4218 (5.7); 1.2595 (0.6); 0.0079 (0.8); -0.0002 (22.9); -0.0085 (0.7) I.1-194: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6583 (7.6); 8.6522 (8.7); 8.5860 (7.9); 8.5800 (6.7); 8.2675 (9.3); 8.2465 (10.2); 7.7821 (10.0); 7.7611 (9.3); 7.5513 (4.0); 7.5473 (4.4); 7.5314 (4.5); 7.5274 (5.0); 7.5191 (0.9); 7.4964 (4.1); 7.4925 (3.8); 7.4772 (5.1); 7.4733 (4.4); 7.3325 (2.3); 7.3135 (2.5); 7.2860 (5.2); 7.2662 (11.3); 7.2608 (113.8); 7.2468 (4.1); 6.9972 (0.6); 5.7559 (0.6); 5.7399 (2.1); 5.7230 (2.5); 5.7035 (2.1); 5.6858 (0.5); 1.4888 (16.0); 1.4722 (15.9); 0.1455 (0.6); 0.0330 (0.8); 0.0079 (4.8); -0.0002 (133.5); -0.0085 (5.3); -0.1494 (0.7) I.1-195: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6756 (6.5); 8.6696 (7.6); 8.6013 (7.8); 8.5953 (6.8); 8.2581 (10.1); 8.2373 (11.3); 7.7767 (10.6); 7.7558 (10.0); 7.6904 (7.7); 7.6696 (8.7); 7.6211 (2.4); 7.6013 (2.5); 7.4466 (8.8); 7.4416 (9.4); 7.3332 (5.4); 7.3282 (4.9); 7.3123 (4.8); 7.3073 (4.5); 7.2607 (70.2); 5.7662 (0.6); 5.7495 (2.3); 5.7304 (2.9); 5.7133 (2.3); 5.6970 (0.6); 1.5062 (16.0); 1.4896 (15.9); 0.0281 (0.5); 0.0079 (3.7); -0.0002 (101.8); -0.0084 (3.4) BCS241005-Ausland STR 147 I.1-196: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0822 (0.6); 9.0649 (0.6); 8.7318 (1.6); 8.7257 (2.0); 8.6890 (2.4); 8.6829 (1.9); 8.1291 (2.1); 8.1243 (0.7); 8.1125 (0.8); 8.1077 (2.5); 7.8287 (2.3); 7.8238 (0.7); 7.8121 (0.7); 7.8073 (2.1); 7.4841 (2.8); 7.4830 (3.1); 7.4799 (4.6); 7.2215 (1.3); 7.2183 (1.4); 7.2173 (1.6); 7.2142 (1.2); 5.2809 (0.7); 3.9089 (9.1); 3.3198 (16.0); 2.5409 (0.6); 2.5296 (0.7); 2.5241 (1.1); 2.5193 (1.4); 2.5106 (11.8); 2.5060 (24.6); 2.5014 (33.8); 2.4969 (23.5); 2.4923 (10.5); 1.4512 (2.7); 1.4342 (2.7); -0.0002 (14.6) I.1-197: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7242 (1.1); 8.7181 (1.4); 8.6830 (1.8); 8.6769 (1.4); 8.1307 (1.5); 8.1141 (0.6); 8.1093 (1.8); 7.8762 (1.4); 7.8716 (1.4); 7.8265 (1.7); 7.8217 (0.5); 7.8099 (0.5); 7.8052 (1.5); 7.6208 (0.8); 7.6160 (0.7); 7.6004 (0.8); 7.5956 (0.8); 7.1893 (1.4); 7.1689 (1.2); 5.2441 (0.5); 3.9092 (6.4); 3.3193 (16.0); 2.5327 (0.6); 2.5238 (1.2); 2.5192 (1.5); 2.5104 (11.8); 2.5058 (24.2); 2.5013 (33.0); 2.4967 (22.7); 2.4921 (10.0); 1.4391 (1.9); 1.4220 (1.8); -0.0002 (14.0) I.1-198: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1470 (2.0); 9.1017 (0.9); 9.0842 (1.0); 8.7285 (2.4); 8.7224 (3.1); 8.6883 (3.6); 8.6823 (2.9); 8.1075 (3.1); 8.1029 (1.0); 8.0911 (1.1); 8.0863 (3.7); 8.0821 (0.5); 7.8023 (3.4); 7.7975 (1.0); 7.7858 (1.0); 7.7811 (3.0); 7.4879 (4.8); 7.4845 (7.0); 7.2432 (1.9); 7.2392 (2.6); 7.2358 (1.7); 5.3010 (0.6); 5.2839 (1.0); 5.2667 (0.7); 3.3349 (16.0); 2.5252 (1.0); 2.5205 (1.4); 2.5117 (18.2); 2.5072 (39.4); 2.5026 (54.3); 2.4981 (37.1); 2.4935 (16.0); 1.4496 (3.8); 1.4326 (3.8); 0.0080 (1.2); -0.0002 (42.9); -0.0085 (1.2) I.1-199: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7200 (1.1); 8.7139 (1.5); 8.6820 (1.8); 8.6759 (1.4); 8.1072 (1.4); 8.0908 (0.5); 8.0861 (1.7); 7.8816 (1.5); 7.8769 (1.5); 7.7972 (1.6); 7.7760 (1.4); 7.6223 (0.8); 7.6176 (0.7); 7.6019 (0.8); 7.5972 (0.8); 7.1931 (1.4); 7.1728 (1.3); 3.3317 (16.0); 2.6708 (0.6); 2.5245 (1.6); 2.5199 (2.3); 2.5111 (31.3); 2.5065 (67.4); 2.5020 (92.7); 2.4974 (63.2); 2.4929 (27.3); 2.3290 (0.5); 1.4384 (1.8); 1.4214 (1.8); 0.0080 (2.6); -0.0002 (85.3); -0.0060 (0.6); -0.0085 (2.2) I.1-200: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6441 (2.5); 8.6381 (3.1); 8.5862 (2.8); 8.5801 (2.3); 8.2336 (0.5); 8.2293 (3.2); 8.2248 (1.0); 8.2129 (1.1); 8.2083 (3.5); 7.7458 (0.6); 7.7416 (3.5); 7.7371 (1.1); 7.7252 (1.0); 7.7207 (3.2); 7.6995 (0.5); 7.6940 (0.6); 7.6807 (0.6); 7.6749 (0.7); 7.6673 (0.6); 7.6540 (0.5); 7.6485 (0.6); 7.5572 (0.6); 7.3179 (0.5); 7.2984 (0.5); 7.2625 (7.1); 7.2416 (0.8); 7.2369 (0.7); 7.2205 (0.6); 7.2174 (0.8); 7.1963 (0.5); 5.6722 (0.7); 5.6552 (0.8); 5.6360 (0.7); 3.9723 (16.0); 1.6101 (1.4); 1.4041 (5.7); 1.3874 (5.7); -0.0002 (8.8) BCS241005-Ausland STR 148 I.1-201: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6503 (2.6); 8.6442 (3.1); 8.5942 (2.8); 8.5881 (2.2); 8.2358 (0.6); 8.2315 (3.2); 8.2270 (1.0); 8.2151 (1.1); 8.2105 (3.5); 8.2062 (0.5); 7.7412 (0.6); 7.7370 (3.5); 7.7323 (1.1); 7.7205 (1.1); 7.7160 (3.2); 7.3551 (0.5); 7.3490 (0.7); 7.3435 (1.7); 7.3378 (1.9); 7.3346 (1.3); 7.3275 (1.5); 7.3242 (2.0); 7.3186 (1.5); 7.2616 (10.6); 6.9782 (0.6); 6.9626 (0.7); 6.9568 (1.2); 6.9510 (0.6); 6.9355 (0.6); 5.6690 (0.7); 5.6519 (0.8); 5.6327 (0.7); 3.9737 (16.0); 1.5869 (3.1); 1.4056 (5.7); 1.3889 (5.7); -0.0002 (13.7) I.1-202: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6600 (2.6); 8.6539 (3.1); 8.5998 (2.8); 8.5938 (2.3); 8.2350 (3.3); 8.2304 (1.0); 8.2184 (1.1); 8.2139 (3.5); 7.8384 (2.7); 7.8336 (2.9); 7.7325 (3.6); 7.7278 (1.1); 7.7113 (4.4); 7.3439 (0.6); 7.3247 (0.6); 7.2605 (30.3); 5.6627 (0.7); 5.6450 (0.8); 5.6266 (0.7); 3.9747 (16.0); 2.0455 (0.6); 1.5524 (8.7); 1.4156 (5.5); 1.3989 (5.4); 0.0079 (1.3); -0.0002 (42.7); -0.0085 (1.2) I.1-203: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7001 (8.8); 8.6940 (10.4); 8.6236 (9.2); 8.6174 (8.0); 8.2866 (10.0); 8.2823 (3.3); 8.2701 (3.6); 8.2656 (11.2); 8.1678 (0.6); 8.1632 (0.6); 7.8927 (9.6); 7.8878 (10.1); 7.7816 (11.0); 7.7772 (3.5); 7.7650 (3.4); 7.7606 (10.3); 7.7556 (2.5); 7.7515 (4.5); 7.7480 (5.6); 7.7437 (4.1); 7.6273 (2.6); 7.6078 (2.7); 7.2615 (53.2); 5.7305 (0.5); 5.7139 (2.1); 5.6959 (2.8); 5.6778 (2.2); 5.6609 (0.6); 2.8241 (0.8); 1.4839 (15.2); 1.4672 (16.0); 1.4322 (1.0); 1.3034 (0.7); 1.2844 (1.3); 1.2815 (1.3); 1.2635 (3.6); 1.2226 (0.6); 0.8986 (1.6); 0.8819 (5.7); 0.8641 (2.5); -0.0002 (67.5); -0.0084 (3.5); - 0.0340 (0.5) I.1-204: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1056 (2.7); 8.9760 (2.8); 8.9599 (2.8); 8.6775 (4.5); 8.6720 (6.0); 8.6537 (6.0); 8.6483 (4.4); 8.0702 (6.4); 8.0499 (7.2); 7.8909 (1.4); 7.8701 (1.9); 7.8421 (1.4); 7.7965 (7.3); 7.7762 (6.3); 7.7065 (2.0); 7.5365 (1.1); 7.5155 (2.1); 7.4902 (2.0); 7.4687 (0.9); 5.3127 (1.8); 5.2954 (2.6); 5.2792 (1.7); 3.3258 (16.0); 2.6726 (0.6); 2.5035 (85.0); 2.3307 (0.6); 1.4606 (9.6); 1.4436 (9.4); -0.0002 (24.8) I.1-205: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1090 (2.5); 9.0405 (3.9); 9.0241 (3.9); 8.6839 (6.5); 8.6780 (9.2); 8.6596 (9.3); 8.6537 (6.5); 8.0712 (9.4); 8.0507 (10.9); 7.7908 (10.7); 7.7703 (9.4); 7.5232 (6.4); 7.5074 (6.1); 7.4583 (1.4); 7.4526 (1.9); 7.4356 (2.6); 7.4299 (3.5); 7.4128 (1.4); 7.4074 (1.8); 5.3342 (0.7); 5.3180 (2.5); 5.3012 (3.7); 5.2843 (2.4); 5.2672 (0.6); 3.3922 (0.6); 3.3744 (0.8); 3.3282 (16.0); 2.6730 (0.6); 2.5080 (72.5); 2.5042 (90.1); 2.5003 (70.4); 2.3313 (0.6); 1.4690 (13.9); 1.4518 (13.6); 1.0914 (0.9); -0.0002 (31.4) I.1-206: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6553 (2.2); 8.6492 (2.8); 8.6018 (2.5); 8.5958 (2.0); 8.2319 (2.9); 8.2109 (3.3); 7.8222 (0.5); 7.8095 (10.0); 7.7300 (3.2); 7.7090 (3.0); 7.3089 (0.7); 7.2891 (0.8); 7.2604 (32.0); 5.6526 (0.7); 5.6336 (0.8); 5.6165 (0.7); 3.9742 (14.0); 1.5470 (16.0); 1.4084 (5.1); 1.3917 (5.1); 0.0078 (1.8); -0.0002 (45.7); -0.0085 (1.5) BCS241005-Ausland STR 149 I.1-207: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6549 (2.6); 8.6489 (3.2); 8.6023 (2.8); 8.5962 (2.3); 8.2317 (3.3); 8.2273 (1.2); 8.2152 (1.2); 8.2106 (3.7); 7.9671 (2.8); 7.9621 (3.0); 7.8507 (3.0); 7.8457 (2.8); 7.7308 (3.6); 7.7263 (1.3); 7.7143 (1.2); 7.7097 (3.3); 7.2956 (0.8); 7.2765 (0.8); 7.2607 (20.6); 5.6498 (0.8); 5.6310 (0.9); 5.6137 (0.7); 3.9739 (16.0); 1.5611 (4.2); 1.4097 (5.6); 1.3930 (5.6); 1.2641 (0.8); 0.8819 (1.3); 0.8642 (0.5); 0.0079 (1.1); -0.0002 (29.2); -0.0085 (1.0) I.1-208: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6372 (1.6); 8.6312 (2.0); 8.5928 (1.8); 8.5867 (1.4); 8.2297 (2.1); 8.2251 (0.7); 8.2131 (0.8); 8.2086 (2.3); 8.1424 (0.9); 8.1383 (1.6); 8.1341 (0.8); 7.8494 (0.6); 7.8468 (0.7); 7.8428 (0.5); 7.8297 (0.6); 7.8271 (0.7); 7.8231 (0.5); 7.7747 (0.6); 7.7719 (0.7); 7.7682 (0.6); 7.7551 (1.1); 7.7510 (3.0); 7.7342 (0.8); 7.7297 (2.0); 7.2612 (13.2); 7.2021 (0.8); 7.1826 (1.5); 7.1631 (0.7); 5.6592 (0.6); 3.9715 (10.2); 1.5616 (16.0); 1.4117 (3.6); 1.3950 (3.6); 0.0078 (0.6); -0.0002 (13.3) I.1-209: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6324 (2.1); 8.6263 (2.5); 8.5769 (2.2); 8.5708 (1.8); 8.2256 (2.5); 8.2210 (0.9); 8.2091 (1.0); 8.2044 (2.9); 7.8052 (2.7); 7.8006 (0.9); 7.7886 (1.0); 7.7839 (3.2); 7.7493 (2.8); 7.7447 (1.0); 7.7327 (0.9); 7.7281 (2.6); 7.5477 (3.1); 7.5430 (1.0); 7.5310 (0.9); 7.5264 (2.7); 7.3187 (0.5); 7.2989 (0.6); 7.2613 (12.7); 5.6814 (0.6); 5.6641 (0.7); 5.6451 (0.6); 3.9698 (12.7); 1.5677 (16.0); 1.4027 (4.4); 1.3860 (4.4); 0.0080 (0.5); -0.0002 (13.4) I.1-210: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6487 (2.6); 8.6427 (3.4); 8.6056 (3.1); 8.5995 (2.4); 8.2302 (3.5); 8.2260 (1.3); 8.2136 (1.4); 8.2093 (4.0); 8.1806 (1.6); 8.1769 (3.0); 8.1732 (1.8); 8.0648 (6.5); 8.0611 (6.2); 7.7371 (3.8); 7.7328 (1.4); 7.7204 (1.3); 7.7161 (3.6); 7.2631 (8.1); 7.2369 (0.8); 7.2174 (0.8); 5.6412 (0.8); 5.6236 (1.0); 5.6050 (0.8); 3.9728 (16.0); 1.5999 (1.1); 1.4088 (5.9); 1.3920 (5.8); - 0.0002 (11.7) I.1-211: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0227 (0.6); 9.0062 (0.6); 8.6809 (1.3); 8.6748 (1.9); 8.6527 (2.2); 8.6467 (1.5); 8.2751 (1.5); 8.2700 (1.4); 8.0808 (1.8); 8.0761 (0.6); 8.0643 (0.7); 8.0595 (2.2); 7.9742 (1.5); 7.9537 (1.7); 7.8066 (2.1); 7.8018 (0.6); 7.7900 (0.6); 7.7853 (1.8); 7.5044 (0.8); 7.4992 (0.8); 7.4839 (0.8); 7.4786 (0.8); 5.2694 (0.6); 3.9012 (7.9); 3.3207 (16.0); 2.5248 (1.2); 2.5201 (1.5); 2.5113 (11.1); 2.5068 (22.8); 2.5022 (31.1); 2.4976 (21.4); 2.4931 (9.4); 1.9893 (0.5); 1.4496 (2.2); 1.4323 (2.1); 0.8576 (0.8); 0.0081 (0.6); -0.0002 (19.4); -0.0085 (0.6) I.1-212: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1465 (0.9); 9.1835 (3.2); 9.1682 (3.2); 8.6856 (6.3); 8.6655 (6.3); 8.0659 (7.1); 8.0460 (8.5); 8.0227 (16.0); 7.7791 (7.7); 7.7592 (6.7); 5.3117 (2.0); 5.2951 (2.8); 5.2788 (2.0); 3.3423 (10.3); 2.6722 (0.7); 2.5058 (83.1); 2.3339 (0.6); 1.4786 (10.3); 1.4618 (10.0); -0.0002 (25.0) BCS241005-Ausland STR 150 I.1-213: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1290 (3.1); 9.1847 (3.6); 9.1696 (3.5); 8.6859 (6.8); 8.6651 (6.8); 8.1539 (6.7); 8.0677 (8.1); 8.0462 (12.1); 7.7813 (8.2); 7.7616 (7.2); 5.3081 (2.3); 5.2929 (3.1); 5.2765 (2.1); 3.3406 (16.0); 2.6728 (0.9); 2.5061 (89.5); 2.3325 (0.6); 1.4757 (11.3); 1.4593 (10.6); -0.0002 (23.7) I.1-214: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1250 (6.2); 9.0143 (4.7); 8.9981 (4.7); 8.6791 (7.8); 8.6732 (10.9); 8.6541 (11.3); 8.6482 (7.7); 8.1770 (9.4); 8.0809 (11.3); 8.0603 (13.0); 7.8753 (4.9); 7.8559 (5.1); 7.8092 (14.6); 7.7885 (13.7); 7.2470 (4.2); 7.2275 (7.7); 7.2080 (3.7); 5.3253 (0.8); 5.3090 (2.8); 5.2922 (4.3); 5.2753 (2.8); 5.2587 (0.7); 3.6178 (1.2); 3.6014 (2.8); 3.5851 (1.2); 3.3910 (1.4); 3.3735 (1.5); 3.3382 (13.4); 2.6732 (0.8); 2.5082 (106.3); 2.5043 (129.5); 2.3315 (0.8); 1.7754 (1.2); 1.7593 (3.1); 1.7512 (1.5); 1.7430 (1.2); 1.4523 (16.0); 1.4352 (15.7); 1.1085 (1.4); 1.0910 (2.6); 1.0735 (1.3); -0.0002 (62.9) I.1-215: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6510 (2.6); 8.6449 (3.1); 8.5889 (2.7); 8.5828 (2.2); 8.2418 (0.5); 8.2376 (3.2); 8.2329 (1.0); 8.2211 (1.1); 8.2163 (3.5); 8.2122 (0.6); 7.9394 (1.8); 7.9192 (2.3); 7.7606 (0.6); 7.7564 (3.5); 7.7517 (1.1); 7.7399 (1.1); 7.7352 (3.3); 7.7308 (0.7); 7.7235 (2.4); 7.7030 (2.0); 7.4291 (0.6); 7.4094 (0.6); 7.2626 (12.6); 5.7114 (0.7); 5.6944 (0.8); 5.6751 (0.7); 3.9756 (16.0); 1.6060 (0.7); 1.4257 (5.4); 1.4090 (5.4); 0.0079 (0.6); -0.0002 (18.6); -0.0085 (0.5) I.1-216: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6499 (2.6); 8.6438 (3.1); 8.5886 (2.6); 8.5825 (2.2); 8.2374 (3.1); 8.2327 (1.0); 8.2209 (1.1); 8.2161 (3.6); 8.2119 (0.6); 7.9390 (1.8); 7.9188 (2.2); 7.7603 (0.6); 7.7561 (3.4); 7.7513 (1.1); 7.7395 (1.1); 7.7348 (3.2); 7.7303 (0.7); 7.7233 (2.4); 7.7029 (1.9); 7.4275 (0.5); 7.4078 (0.6); 7.2626 (12.1); 5.7112 (0.7); 5.6941 (0.8); 5.6919 (0.8); 5.6749 (0.7); 3.9755 (16.0); 1.5913 (2.0); 1.4249 (5.3); 1.4081 (5.3); 0.8818 (0.6); -0.0002 (17.5); -0.0085 (0.5) I.1-217: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1260 (7.3); 8.9539 (4.1); 8.9374 (4.3); 8.6714 (7.7); 8.6653 (12.7); 8.6492 (13.6); 8.6431 (8.6); 8.0768 (11.3); 8.0726 (4.2); 8.0603 (4.4); 8.0559 (14.1); 7.8184 (12.2); 7.8136 (6.1); 7.8086 (13.8); 7.8024 (6.5); 7.7972 (16.0); 7.7920 (6.1); 7.7877 (12.0); 7.6060 (14.1); 7.6015 (4.5); 7.5893 (4.1); 7.5848 (12.1); 5.3246 (0.5); 5.3076 (2.5); 5.2907 (3.9); 5.2738 (2.6); 5.2566 (0.6); 3.3393 (5.7); 2.6733 (0.6); 2.5269 (1.7); 2.5222 (2.6); 2.5133 (32.7); 2.5089 (68.8); 2.5044 (93.6); 2.4999 (66.2); 2.4955 (30.1); 2.3315 (0.6); 1.4434 (14.7); 1.4262 (14.6); 1.0909 (0.6); 0.0080 (2.5); -0.0002 (73.8); -0.0085 (2.4) BCS241005-Ausland STR 151 I.1-218: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6676 (2.5); 8.6616 (3.0); 8.5885 (2.3); 8.5824 (2.0); 8.2292 (3.1); 8.2243 (1.0); 8.2127 (1.0); 8.2078 (3.4); 8.2036 (0.5); 7.7071 (3.1); 7.7022 (1.0); 7.6905 (0.9); 7.6857 (2.9); 7.3678 (6.2); 7.2626 (6.9); 5.6326 (0.6); 5.6157 (0.6); 5.6131 (0.6); 5.5962 (0.6); 3.9738 (16.0); 2.0460 (0.8); 1.6226 (0.6); 1.4059 (4.8); 1.3892 (4.8); 1.2643 (0.5); 1.2599 (0.8); 0.8818 (1.1); - 0.0002 (10.5) I.1-219: 1H-NMR(400.6 MHz, CDCl3): δ= 8.8457 (1.5); 8.8430 (1.7); 8.8256 (1.6); 8.8230 (1.6); 8.6486 (1.3); 8.6425 (3.6); 8.6363 (4.4); 8.6303 (1.6); 8.2365 (3.1); 8.2317 (1.0); 8.2200 (1.0); 8.2151 (3.5); 8.2109 (0.5); 7.7663 (3.4); 7.7615 (1.1); 7.7498 (1.0); 7.7449 (3.1); 7.5407 (0.9); 7.5380 (1.2); 7.5219 (2.3); 7.5192 (2.2); 7.4953 (2.1); 7.4753 (2.1); 7.4565 (1.1); 7.2606 (22.0); 5.7167 (0.6); 5.6999 (0.7); 5.6962 (0.7); 5.6794 (0.6); 5.2999 (2.2); 3.9761 (16.0); 1.4943 (5.0); 1.4776 (5.0); 1.2544 (1.0); 0.0079 (0.9); -0.0002 (32.9); -0.0085 (0.9) I.1-220: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4210 (2.0); 9.4042 (2.1); 8.7135 (4.9); 8.7074 (7.8); 8.6887 (8.9); 8.6826 (5.9); 8.0722 (0.9); 8.0680 (6.9); 8.0634 (2.3); 8.0516 (2.3); 8.0468 (8.4); 8.0427 (1.3); 7.9924 (16.0); 7.7557 (1.2); 7.7516 (7.7); 7.7469 (2.5); 7.7351 (2.2); 7.7304 (7.0); 7.7263 (1.1); 5.2889 (1.4); 5.2718 (2.3); 5.2548 (1.5); 3.3296 (0.8); 3.1716 (2.5); 2.5274 (0.7); 2.5228 (0.9); 2.5140 (14.5); 2.5094 (32.7); 2.5048 (46.2); 2.5003 (32.5); 2.4957 (14.6); 2.1843 (0.7); 1.9118 (1.2); 1.4917 (8.7); 1.4745 (8.7); 1.3568 (6.1); 1.1824 (0.9); 0.0080 (0.7); -0.0002 (25.3); -0.0085 (0.7) I.1-221: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0953 (0.6); 9.0773 (0.7); 8.7364 (1.4); 8.7303 (2.1); 8.7047 (2.4); 8.6986 (1.8); 8.5565 (1.1); 8.5545 (1.2); 8.5359 (1.2); 8.5340 (1.2); 8.0787 (2.0); 8.0741 (0.7); 8.0623 (0.7); 8.0575 (2.4); 7.8267 (1.0); 7.8246 (1.2); 7.8077 (1.4); 7.8058 (1.3); 7.7887 (2.2); 7.7839 (0.7); 7.7722 (0.6); 7.7674 (2.0); 7.6344 (1.1); 7.6154 (1.2); 7.6139 (1.3); 7.5950 (1.0); 5.7577 (1.0); 5.4249 (0.6); 3.3214 (16.0); 2.5249 (0.9); 2.5203 (1.2); 2.5115 (16.4); 2.5069 (36.5); 2.5023 (51.3); 2.4977 (36.0); 2.4932 (16.2); 1.4888 (2.5); 1.4719 (2.5); 0.0080 (0.6); -0.0002 (21.1); -0.0085 (0.6) I.1-222: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6427 (1.7); 8.6367 (4.2); 8.6294 (3.3); 8.6233 (1.3); 8.2479 (0.9); 8.2456 (1.6); 8.2420 (3.5); 8.2371 (1.0); 8.2279 (1.0); 8.2255 (2.2); 8.2205 (3.5); 8.2163 (0.5); 7.7580 (3.3); 7.7531 (1.0); 7.7415 (0.9); 7.7366 (3.0); 7.6267 (1.3); 7.6244 (1.6); 7.6234 (1.5); 7.6211 (1.3); 7.6178 (1.3); 7.6149 (1.2); 7.6016 (1.2); 7.5986 (1.1); 7.4276 (0.8); 7.4241 (0.8); 7.4114 (0.7); 7.4077 (1.4); 7.4041 (0.8); 7.3913 (0.7); 7.3878 (0.7); 7.2614 (10.3); 5.7500 (0.6); 5.7332 (0.6); 5.7297 (0.6); 5.7129 (0.6); 5.2997 (2.2); 3.9780 (16.0); 1.4878 (5.0); 1.4711 (5.0); 1.2551 (0.5); -0.0002 (15.3) BCS241005-Ausland STR 152 I.1-223: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6268 (2.1); 8.6207 (3.6); 8.6044 (2.9); 8.5983 (1.7); 8.5872 (1.0); 8.5812 (1.6); 8.5637 (0.8); 8.2234 (0.6); 8.2192 (3.2); 8.2144 (1.0); 8.2027 (1.1); 8.1978 (3.5); 8.1954 (1.9); 8.1905 (0.6); 8.1788 (0.6); 8.1739 (1.7); 7.7443 (0.5); 7.7400 (3.4); 7.7352 (1.0); 7.7235 (1.0); 7.7186 (3.2); 7.7143 (0.9); 7.6925 (0.5); 7.2632 (16.0); 5.6562 (0.6); 5.6393 (0.7); 5.6358 (0.7); 5.6190 (0.6); 5.3003 (2.8); 3.9710 (16.0); 3.9609 (5.1); 3.9533 (0.9); 3.0125 (3.6); 2.3256 (1.1); 1.4261 (6.4); 1.4197 (2.9); 1.4094 (6.1); 1.2922 (0.7); 1.2745 (0.7); 1.2103 (1.4); 1.1512 (0.6); 1.1331 (1.0); 0.0079 (0.6); -0.0002 (23.9); -0.0085 (0.7) I.1-224: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6780 (2.4); 8.6719 (3.1); 8.6322 (2.6); 8.6261 (2.0); 8.2326 (3.2); 8.2278 (1.0); 8.2161 (1.0); 8.2113 (3.4); 8.2071 (0.5); 7.6962 (3.3); 7.6914 (1.0); 7.6797 (1.0); 7.6749 (3.0); 7.2605 (30.5); 5.6443 (0.7); 5.6266 (0.9); 5.6092 (0.7); 3.9771 (16.0); 1.5446 (5.4); 1.4571 (5.2); 1.4405 (5.2); 0.0079 (1.2); -0.0002 (45.3); -0.0085 (1.3) I.1-225: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6481 (2.4); 8.6420 (2.9); 8.5860 (2.4); 8.5799 (2.0); 8.2302 (2.8); 8.2254 (1.0); 8.2137 (1.0); 8.2089 (3.2); 8.2047 (0.5); 7.7302 (3.0); 7.7254 (1.0); 7.7137 (0.9); 7.7089 (2.8); 7.4563 (2.4); 7.4511 (2.5); 7.2607 (27.5); 6.6034 (2.5); 6.5981 (2.5); 5.6451 (0.6); 5.6282 (0.6); 5.6250 (0.6); 5.6082 (0.6); 4.1499 (16.0); 3.9736 (15.4); 1.6086 (0.7); 1.3957 (5.0); 1.3790 (5.0); 0.0079 (1.1); -0.0002 (39.6); -0.0085 (1.1) I.1-226: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8204 (0.9); 8.8032 (0.9); 8.6903 (2.0); 8.6842 (3.2); 8.6646 (3.7); 8.6585 (2.5); 8.0746 (2.8); 8.0699 (1.0); 8.0581 (1.0); 8.0533 (3.4); 8.0492 (0.6); 7.7779 (3.1); 7.7731 (1.0); 7.7613 (0.9); 7.7566 (2.8); 7.4127 (3.2); 7.4075 (3.4); 6.9330 (3.2); 6.9278 (3.2); 5.3203 (0.6); 5.3032 (1.0); 5.2859 (0.6); 3.9079 (16.0); 3.3238 (12.1); 2.5249 (0.6); 2.5202 (0.8); 2.5114 (13.0); 2.5069 (29.3); 2.5023 (41.6); 2.4977 (29.4); 2.4931 (13.4); 1.4368 (3.7); 1.4196 (3.7); 1.3557 (1.6); 0.0080 (1.0); -0.0002 (35.0); -0.0058 (0.5); -0.0085 (1.0) I.1-227: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3567 (2.4); 9.3396 (2.4); 8.7292 (5.9); 8.7231 (8.4); 8.6981 (10.2); 8.6920 (7.4); 8.0917 (1.1); 8.0875 (8.0); 8.0828 (2.8); 8.0710 (2.7); 8.0662 (9.8); 7.9604 (2.1); 7.9576 (3.3); 7.9553 (2.5); 7.9403 (2.6); 7.9382 (3.9); 7.9354 (2.7); 7.8601 (2.1); 7.8583 (4.2); 7.8563 (2.4); 7.8390 (3.0); 7.8370 (5.7); 7.8350 (3.0); 7.8016 (1.4); 7.7974 (8.9); 7.7926 (2.9); 7.7809 (2.4); 7.7762 (8.0); 7.7720 (1.2); 7.7360 (2.5); 7.7329 (2.6); 7.7184 (2.9); 7.7151 (3.7); 7.7117 (2.0); 7.6971 (2.2); 7.6940 (2.2); 7.4734 (2.4); 7.4715 (2.6); 7.4557 (2.6); 7.4536 (4.3); 7.4515 (2.9); 7.4358 (2.1); 7.4338 (2.2); 6.8717 (1.1); 6.6415 (0.7); 5.7581 (7.7); 5.4423 (1.7); 5.4252 (2.8); 5.4080 (1.8); 3.8854 (1.6); 3.3251 (9.5); 2.6719 (0.7); 2.5425 (1.7); 2.5257 (1.4); 2.5211 (2.1); 2.5123 (36.1); 2.5077 (81.6); 2.5031 (115.4); 2.4985 (81.0); 2.4939 (36.4); 2.3302 (0.7); 2.1839 (1.8); 1.9104 (2.0); 1.4918 (10.2); 1.4747 (10.2); 1.3562 (16.0); 1.2334 (0.8); 1.1819 (1.7); 1.1753 (0.6); 0.0080 (2.4); 0.0057 (0.6); - 0.0002 (91.7); -0.0085 (2.6) BCS241005-Ausland STR 153 I.1-228: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1272 (0.9); 9.0920 (1.3); 9.0742 (1.4); 8.7221 (3.2); 8.7159 (5.1); 8.6980 (6.0); 8.6919 (4.0); 8.0954 (0.6); 8.0911 (4.6); 8.0864 (1.6); 8.0747 (1.6); 8.0699 (5.5); 8.0658 (0.9); 7.7658 (0.8); 7.7617 (5.1); 7.7569 (1.6); 7.7452 (1.4); 7.7405 (4.7); 7.7362 (0.7); 6.8707 (0.5); 5.7574 (4.1); 5.3032 (1.0); 5.2859 (1.6); 5.2685 (1.0); 3.3222 (16.0); 2.5417 (0.9); 2.5249 (1.0); 2.5203 (1.3); 2.5115 (21.3); 2.5069 (47.8); 2.5023 (67.6); 2.4977 (47.7); 2.4932 (21.6); 2.1835 (0.8); 1.4419 (6.0); 1.4249 (6.0); 1.3556 (7.6); 1.1813 (1.2); 0.0080 (1.4); -0.0002 (53.6); -0.0085 (1.6) I.1-231: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7300 (0.5); 8.6740 (1.1); 8.6680 (1.7); 8.6475 (1.9); 8.6414 (1.4); 8.0718 (1.5); 8.0671 (0.6); 8.0553 (0.6); 8.0506 (1.9); 8.0394 (1.8); 8.0351 (1.8); 7.7890 (1.7); 7.7843 (0.6); 7.7724 (0.5); 7.7678 (1.6); 7.5035 (1.8); 7.4991 (1.7); 5.2339 (0.5); 3.3193 (16.0); 2.5238 (0.8); 2.5192 (1.4); 2.5104 (20.5); 2.5059 (43.7); 2.5013 (60.4); 2.4967 (41.4); 2.4921 (18.1); 1.9887 (1.7); 1.4321 (2.0); 1.4149 (2.0); 1.3551 (0.6); 1.1923 (0.5); 1.1745 (1.1); 1.1567 (0.5); 0.0080 (1.1); 0.0056 (0.5); -0.0002 (32.5); -0.0085 (0.8) I.1-233: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6967 (0.7); 8.6906 (1.2); 8.6708 (1.4); 8.6646 (0.9); 8.3920 (1.2); 8.3910 (1.2); 8.0938 (1.1); 8.0724 (1.3); 7.7884 (1.2); 7.7671 (1.1); 3.9009 (5.1); 3.3190 (16.0); 2.5239 (0.5); 2.5193 (0.8); 2.5105 (11.3); 2.5059 (25.2); 2.5013 (35.4); 2.4967 (24.4); 2.4921 (10.8); 2.2613 (3.9); 1.4059 (1.4); 1.3888 (1.4); -0.0002 (8.6) I.1-234: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7028 (0.6); 8.6966 (0.9); 8.6748 (1.1); 8.6688 (0.8); 8.1014 (0.9); 8.0800 (1.0); 7.7933 (1.0); 7.7719 (0.9); 6.4660 (0.8); 6.4637 (0.8); 3.9031 (3.9); 3.3181 (16.0); 2.5237 (0.7); 2.5190 (0.9); 2.5102 (14.0); 2.5057 (30.9); 2.5011 (43.4); 2.4965 (29.7); 2.4919 (12.9); 2.4317 (2.3); 2.4296 (2.2); 1.4224 (1.1); 1.4053 (1.1); -0.0002 (11.2) I.1-235: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7251 (1.4); 8.7189 (2.1); 8.6938 (2.5); 8.6877 (1.8); 8.1064 (2.1); 8.1016 (0.6); 8.0899 (0.7); 8.0850 (2.5); 7.7959 (2.2); 7.7910 (0.7); 7.7793 (0.6); 7.7745 (2.0); 5.2994 (0.7); 3.9035 (9.4); 3.3184 (16.0); 2.6699 (0.5); 2.6617 (12.8); 2.5407 (0.8); 2.5238 (0.9); 2.5192 (1.3); 2.5104 (18.5); 2.5059 (40.7); 2.5012 (57.2); 2.4966 (39.2); 2.4921 (17.1); 1.9887 (1.6); 1.4472 (2.6); 1.4300 (2.6); 1.1745 (1.0); 0.0080 (1.3); 0.0039 (0.6); 0.0022 (1.7); -0.0002 (44.0); -0.0027 (2.0); -0.0043 (0.6); -0.0085 (1.2) BCS241005-Ausland STR 154 I.1-236: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6910 (1.4); 8.6849 (2.3); 8.6686 (2.7); 8.6624 (1.7); 8.6347 (0.6); 8.6172 (0.6); 8.3948 (2.3); 8.3938 (2.3); 8.0736 (2.0); 8.0689 (0.7); 8.0571 (0.7); 8.0523 (2.4); 7.7611 (2.2); 7.7563 (0.7); 7.7446 (0.6); 7.7399 (2.0); 5.2928 (0.7); 4.0378 (1.3); 4.0201 (1.3); 3.3194 (16.0); 2.6702 (0.6); 2.5407 (1.4); 2.5239 (1.7); 2.5193 (2.3); 2.5105 (31.8); 2.5059 (69.7); 2.5013 (97.5); 2.4967 (66.4); 2.4921 (28.8); 2.3284 (0.6); 2.2682 (7.2); 1.9887 (6.2); 1.9085 (2.0); 1.4059 (2.5); 1.3888 (2.6); 1.3551 (2.3); 1.1923 (1.9); 1.1745 (3.8); 1.1567 (1.8); 0.8525 (0.7); 0.8459 (0.7); 0.0080 (2.1); 0.0048 (0.6); 0.0039 (0.9); 0.0023 (2.7); -0.0002 (74.5); -0.0026 (3.3); -0.0042 (1.1); -0.0051 (0.7); -0.0059 (0.6); -0.0067 (0.6); -0.0085 (2.0) I.1-237: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9422 (2.5); 8.9253 (2.5); 8.6982 (6.1); 8.6921 (9.8); 8.6844 (0.6); 8.6737 (11.7); 8.6676 (8.0); 8.0867 (1.3); 8.0825 (9.0); 8.0778 (2.9); 8.0661 (3.1); 8.0612 (10.5); 8.0571 (1.6); 8.0526 (0.6); 7.7718 (1.6); 7.7677 (10.0); 7.7629 (3.4); 7.7512 (2.8); 7.7464 (9.0); 7.7421 (1.6); 6.9102 (0.6); 6.4739 (9.1); 6.4716 (9.0); 5.2872 (1.9); 5.2701 (3.1); 5.2530 (2.0); 4.0563 (1.1); 4.0385 (3.4); 4.0207 (3.4); 4.0029 (1.1); 3.3234 (13.8); 2.6715 (0.6); 2.5420 (1.2); 2.5253 (1.8); 2.5206 (2.4); 2.5119 (31.4); 2.5073 (68.9); 2.5027 (96.4); 2.4981 (66.0); 2.4935 (28.8); 2.4343 (24.1); 2.4321 (23.4); 2.3298 (0.6); 2.2684 (1.5); 2.1836 (0.7); 2.1328 (1.3); 2.1256 (1.2); 1.9893 (16.0); 1.9099 (4.4); 1.4453 (0.6); 1.4242 (11.4); 1.4071 (11.2); 1.3560 (6.4); 1.2588 (0.6); 1.2347 (0.8); 1.1927 (4.8); 1.1815 (0.8); 1.1749 (9.7); 1.1698 (0.5); 1.1572 (4.7); 0.8693 (1.2); 0.8521 (3.3); 0.8481 (2.5); 0.8457 (3.6); 0.8392 (1.1); 0.8280 (1.0); 0.8215 (1.2); 0.8183 (1.9); 0.8126 (0.6); 0.8074 (0.6); 0.7955 (0.6); 0.7923 (0.5); 0.7783 (0.7); 0.7595 (0.6); 0.7524 (1.2); 0.0079 (1.9); 0.0062 (0.5); 0.0053 (0.6); 0.0045 (0.8); -0.0002 (73.5); -0.0053 (0.8); -0.0061 (0.6); -0.0069 (0.6); -0.0085 (2.1) I.1-238: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3611 (1.1); 9.3446 (1.2); 8.7186 (2.9); 8.7125 (4.5); 8.6907 (5.4); 8.6846 (3.7); 8.0872 (0.6); 8.0829 (4.2); 8.0782 (1.3); 8.0665 (1.4); 8.0616 (5.0); 8.0575 (0.7); 7.7701 (0.7); 7.7660 (4.6); 7.7612 (1.4); 7.7495 (1.3); 7.7448 (4.1); 7.7405 (0.6); 5.3254 (0.9); 5.3085 (1.4); 5.2914 (0.9); 4.0557 (0.8); 4.0379 (2.6); 4.0202 (2.6); 4.0024 (0.8); 3.3204 (16.0); 2.6748 (0.8); 2.6666 (27.4); 2.5409 (1.5); 2.5241 (1.8); 2.5194 (2.4); 2.5107 (33.9); 2.5061 (74.2); 2.5015 (104.1); 2.4969 (71.4); 2.4924 (31.0); 2.3286 (0.6); 2.1322 (0.7); 2.1250 (0.7); 1.9887 (12.2); 1.9087 (2.9); 1.4478 (5.3); 1.4307 (5.3); 1.3552 (3.4); 1.1923 (3.7); 1.1746 (7.3); 1.1568 (3.6); 0.8696 (0.6); 0.8523 (1.7); 0.8482 (1.2); 0.8458 (1.8); 0.8394 (0.5); 0.8282 (0.6); 0.8218 (0.6); 0.8186 (0.9); 0.7527 (0.6); 0.0079 (2.3); 0.0063 (0.6); 0.0054 (0.7); 0.0046 (0.9); 0.0038 (1.2); -0.0002 (78.9); -0.0027 (3.2); - 0.0043 (1.1); -0.0052 (0.8); -0.0060 (0.7); -0.0068 (0.6); -0.0085 (2.2) BCS241005-Ausland STR 155 I.1-240: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8418 (0.5); 8.7230 (1.2); 8.7169 (2.0); 8.6998 (2.4); 8.6937 (1.6); 8.1033 (1.8); 8.0985 (0.6); 8.0868 (0.6); 8.0820 (2.1); 7.7759 (2.0); 7.7712 (0.6); 7.7595 (0.6); 7.7547 (1.8); 5.3054 (0.6); 4.0377 (0.6); 4.0200 (0.6); 3.7408 (8.0); 3.3184 (16.0); 2.5405 (1.1); 2.5237 (1.3); 2.5190 (1.8); 2.5103 (26.8); 2.5057 (58.6); 2.5011 (82.0); 2.4965 (56.2); 2.4919 (24.4); 2.1116 (6.7); 1.9885 (3.0); 1.9084 (0.6); 1.4322 (2.3); 1.4152 (2.3); 1.3550 (0.9); 1.1922 (0.9); 1.1744 (1.9); 1.1566 (0.9); 0.0079 (1.3); 0.0046 (0.6); -0.0002 (41.8); -0.0027 (1.4); -0.0085 (1.1) I.1-242: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1785 (1.5); 9.1736 (1.5); 8.7391 (1.0); 8.7330 (1.3); 8.7051 (1.6); 8.6990 (1.1); 8.2962 (1.5); 8.2912 (1.5); 8.1233 (1.3); 8.1021 (1.6); 7.8121 (1.5); 7.7909 (1.3); 3.9101 (5.8); 3.3198 (16.0); 2.5242 (0.6); 2.5195 (0.8); 2.5108 (11.9); 2.5063 (25.8); 2.5017 (35.8); 2.4971 (24.6); 2.4926 (10.8); 1.9890 (1.6); 1.4210 (1.8); 1.4041 (1.8); 1.1747 (0.9); 0.0080 (0.7); -0.0002 (24.9); -0.0085 (0.7) I.1-243: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7296 (0.8); 8.7235 (1.0); 8.6916 (1.2); 8.6855 (0.9); 8.2093 (2.4); 8.1053 (1.0); 8.0840 (1.2); 7.7915 (1.2); 7.7703 (1.0); 3.9053 (4.6); 3.3193 (16.0); 2.5241 (0.7); 2.5194 (0.9); 2.5106 (12.2); 2.5061 (26.1); 2.5015 (36.1); 2.4969 (24.7); 2.4923 (10.7); 1.9888 (1.5); 1.4202 (1.4); 1.4032 (1.4); 1.1746 (0.8); 0.0080 (0.8); -0.0002 (26.2); -0.0086 (0.7) I.1-244: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7059 (0.6); 8.6773 (0.7); 8.6712 (0.5); 8.3024 (1.2); 8.0781 (0.6); 8.0570 (0.7); 7.7752 (0.7); 7.7540 (0.6); 3.8971 (2.6); 3.3187 (16.0); 2.5238 (0.6); 2.5191 (0.9); 2.5103 (12.6); 2.5058 (27.1); 2.5012 (37.4); 2.4967 (25.7); 2.4921 (11.2); 1.4677 (0.8); 1.4505 (0.8); 0.0080 (0.8); -0.0002 (26.2); -0.0085 (0.7) I.1-245: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1786 (3.4); 9.1772 (3.3); 9.1503 (0.8); 9.1335 (0.8); 8.7053 (2.0); 8.6992 (2.8); 8.6703 (3.2); 8.6642 (2.4); 8.5362 (3.4); 8.5347 (3.3); 8.0867 (2.7); 8.0820 (0.8); 8.0703 (1.0); 8.0655 (3.2); 7.8059 (0.5); 7.8017 (3.1); 7.7969 (0.9); 7.7852 (0.9); 7.7805 (2.6); 5.2865 (0.6); 5.2695 (0.9); 5.2524 (0.6); 3.8979 (11.9); 3.3224 (16.0); 2.5251 (0.6); 2.5204 (0.8); 2.5117 (11.1); 2.5071 (24.0); 2.5025 (33.3); 2.4980 (22.8); 2.4934 (9.9); 1.4684 (3.5); 1.4512 (3.5); 0.0080 (0.7); -0.0002 (24.8); -0.0085 (0.7) I.1-246: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7245 (3.6); 8.1270 (1.3); 8.1060 (1.5); 7.7819 (1.4); 7.7609 (1.2); 7.3574 (1.0); 6.8977 (0.8); 6.8952 (0.8); 3.9087 (5.3); 3.3197 (16.0); 2.5242 (0.6); 2.5194 (0.9); 2.5106 (12.4); 2.5061 (26.2); 2.5016 (35.9); 2.4971 (24.8); 2.4926 (11.0); 2.4298 (3.2); 2.4277 (3.0); 1.3745 (1.8); 1.3577 (1.8); 0.0080 (0.7); -0.0002 (23.1); -0.0085 (0.7) BCS241005-Ausland STR 156 I.1-247: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7313 (2.1); 8.7290 (2.3); 8.1303 (1.2); 8.1091 (1.4); 7.8452 (1.3); 7.8314 (1.4); 7.7887 (1.4); 7.7675 (1.2); 7.3964 (1.0); 7.1306 (0.6); 7.1168 (0.6); 3.9097 (5.4); 3.3205 (16.0); 2.5197 (0.6); 2.5110 (8.7); 2.5064 (18.9); 2.5018 (26.3); 2.4972 (18.0); 2.4927 (7.8); 1.9890 (1.1); 1.3915 (1.6); 1.3748 (1.6); 1.1748 (0.6); 0.0080 (0.5); -0.0002 (19.5); -0.0085 (0.5) I.1-248: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7080 (1.0); 8.7019 (1.5); 8.6757 (1.6); 8.6696 (1.2); 8.1171 (1.5); 8.1007 (0.5); 8.0961 (1.7); 7.9121 (1.5); 7.9037 (1.6); 7.8239 (1.7); 7.8193 (0.5); 7.8029 (1.4); 7.6822 (1.5); 7.6738 (1.4); 5.2449 (0.5); 3.9035 (6.2); 3.3208 (16.0); 2.5194 (0.5); 2.5106 (8.7); 2.5061 (18.7); 2.5016 (25.8); 2.4970 (17.7); 2.4925 (7.8); 1.9889 (1.9); 1.4204 (2.0); 1.4034 (2.0); 1.1923 (0.5); 1.1746 (1.0); 1.1568 (0.5); -0.0002 (15.7) I.1-249: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7030 (0.6); 8.6969 (0.8); 8.6712 (0.9); 8.6651 (0.6); 8.1036 (0.8); 8.0827 (0.9); 7.8063 (1.7); 7.7861 (0.7); 3.9032 (3.5); 3.3209 (16.0); 2.5105 (7.0); 2.5060 (15.3); 2.5015 (21.3); 2.4969 (14.8); 2.4924 (6.7); 2.2832 (2.7); 1.9888 (1.4); 1.4174 (1.0); 1.4003 (1.0); 1.1746 (0.8); -0.0002 (12.7) I.1-251: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9939 (0.7); 8.9771 (0.7); 8.6931 (1.5); 8.6870 (2.1); 8.6624 (2.3); 8.6563 (1.6); 8.0859 (2.1); 8.0814 (0.6); 8.0694 (0.7); 8.0649 (2.5); 7.7935 (2.4); 7.7890 (0.7); 7.7770 (0.7); 7.7726 (2.0); 7.7143 (1.7); 7.7042 (1.8); 7.2558 (2.0); 7.2457 (1.9); 5.2284 (0.7); 3.8997 (8.6); 3.3207 (16.0); 2.5244 (0.7); 2.5197 (0.9); 2.5109 (13.1); 2.5064 (28.0); 2.5019 (38.6); 2.4973 (26.7); 2.4928 (11.7); 1.9890 (1.0); 1.4439 (2.7); 1.4267 (2.7); 1.1747 (0.5); 0.0080 (0.7); -0.0002 (22.8); -0.0085 (0.6) I.1-252: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0901 (1.2); 9.0735 (1.2); 8.7043 (2.1); 8.6983 (2.8); 8.6736 (3.0); 8.6676 (2.1); 8.0798 (3.2); 8.0594 (3.5); 7.9365 (4.7); 7.7733 (3.6); 7.7531 (3.1); 5.7578 (1.5); 5.2460 (0.8); 5.2291 (1.2); 5.2121 (0.8); 3.8981 (11.6); 3.3231 (16.0); 2.5075 (26.3); 2.5035 (32.9); 1.9900 (2.1); 1.4621 (4.5); 1.4449 (4.5); 1.1932 (0.6); 1.1754 (1.1); 1.1577 (0.5); -0.0002 (13.6) I.1-253: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0128 (1.4); 8.9958 (1.4); 8.6960 (2.3); 8.6916 (3.0); 8.6659 (3.0); 8.6641 (3.1); 8.6601 (2.3); 8.6581 (2.2); 8.0875 (3.6); 8.0678 (4.0); 7.7944 (4.0); 7.7746 (3.7); 7.7677 (2.8); 7.7573 (2.5); 7.1582 (2.5); 7.1563 (2.6); 7.1481 (2.5); 7.1461 (2.4); 5.2518 (0.9); 5.2347 (1.4); 5.2179 (0.9); 3.9015 (12.5); 3.3241 (15.9); 3.3222 (16.0); 2.5044 (46.5); 2.5030 (46.6); 1.9915 (0.9); 1.9896 (1.0); 1.4481 (5.3); 1.4309 (5.2); 1.1750 (0.5); 0.0020 (15.7); -0.0002 (16.6) BCS241005-Ausland STR 157 I.1-254: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6853 (0.5); 8.6791 (0.8); 8.6569 (0.9); 8.6508 (0.6); 8.0799 (0.7); 8.0586 (0.9); 7.7915 (0.8); 7.7702 (0.7); 7.7362 (0.6); 7.7264 (0.6); 7.0753 (0.7); 7.0655 (0.7); 3.8995 (3.2); 3.3193 (16.0); 2.5192 (0.6); 2.5104 (9.6); 2.5059 (21.0); 2.5013 (29.3); 2.4967 (20.1); 2.4921 (8.8); 1.9887 (0.9); 1.8595 (0.6); 1.8522 (0.6); 1.5197 (0.6); 1.5125 (0.6); 1.4390 (0.9); 1.4217 (0.8); 1.1745 (0.5); 0.0080 (0.8); -0.0002 (26.2); -0.0085 (0.7) I.1-255: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0371 (0.5); 8.6987 (1.1); 8.6926 (1.7); 8.6695 (1.8); 8.6634 (1.3); 8.0782 (1.6); 8.0618 (0.5); 8.0572 (1.8); 7.9039 (2.9); 7.7724 (1.8); 7.7677 (0.5); 7.7559 (0.5); 7.7514 (1.5); 5.7573 (1.1); 5.2153 (0.5); 3.8984 (6.5); 3.3210 (16.0); 2.5246 (0.6); 2.5200 (0.8); 2.5112 (10.4); 2.5067 (22.2); 2.5021 (30.7); 2.4975 (21.0); 2.4930 (9.1); 1.9892 (1.1); 1.4543 (2.0); 1.4371 (2.0); 1.1749 (0.6); 0.0080 (0.6); -0.0002 (19.4); -0.0085 (0.5) I.1-256: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6990 (0.6); 8.6928 (0.8); 8.6676 (0.9); 8.6615 (0.6); 8.0773 (0.8); 8.0560 (0.9); 7.8194 (0.9); 7.7981 (0.8); 3.8905 (3.3); 3.3213 (16.0); 2.5244 (0.6); 2.5197 (0.8); 2.5110 (6.2); 2.5065 (12.8); 2.5019 (17.5); 2.4973 (12.0); 2.4927 (5.3); 1.4976 (1.0); 1.4804 (0.9); -0.0002 (7.6) I.1-257: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6940 (1.0); 8.6878 (1.5); 8.6667 (1.7); 8.6606 (1.2); 8.6572 (0.6); 8.6523 (0.9); 8.6476 (0.6); 8.2203 (0.5); 8.0679 (1.4); 8.0514 (0.5); 8.0468 (1.7); 7.8042 (1.6); 7.7831 (1.4); 7.7490 (0.6); 7.7290 (1.0); 7.7090 (0.5); 3.3357 (16.0); 2.5256 (0.8); 2.5209 (1.0); 2.5121 (12.5); 2.5076 (26.7); 2.5030 (36.6); 2.4985 (25.0); 2.4939 (10.8); 1.4950 (1.7); 1.4777 (1.7); - 0.0002 (15.6) I.1-258: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1275 (1.6); 9.0624 (2.3); 9.0460 (2.4); 8.6757 (4.1); 8.6696 (6.2); 8.6520 (6.5); 8.6459 (4.2); 8.3141 (4.9); 8.3090 (4.8); 8.0732 (6.0); 8.0524 (7.1); 7.9819 (4.5); 7.9614 (5.1); 7.7952 (6.8); 7.7744 (5.9); 7.5228 (2.6); 7.5178 (2.5); 7.5023 (2.4); 7.4972 (2.4); 5.2889 (1.4); 5.2719 (2.1); 5.2552 (1.4); 3.6012 (0.6); 3.3355 (16.0); 2.6722 (0.7); 2.5077 (89.7); 2.5033 (117.2); 2.4990 (84.6); 2.3305 (0.7); 1.7595 (0.7); 1.4443 (7.9); 1.4272 (7.8); 1.0909 (0.5); 0.0077 (3.8); -0.0002 (74.8); -0.0084 (3.2) I.1-259: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1294 (1.2); 9.0992 (2.1); 9.0828 (2.1); 8.6810 (3.7); 8.6749 (5.9); 8.6569 (6.2); 8.6508 (4.1); 8.2257 (2.8); 8.2220 (5.3); 8.2184 (3.2); 8.1340 (11.1); 8.1303 (10.5); 8.0727 (5.5); 8.0518 (6.7); 7.7876 (6.3); 7.7668 (5.6); 5.2870 (1.2); 5.2703 (1.9); 5.2533 (1.2); 3.3337 (16.0); 2.6762 (0.7); 2.6718 (1.0); 2.6671 (0.7); 2.5253 (2.8); 2.5116 (57.4); 2.5073 (119.1); 2.5029 (161.6); 2.4984 (116.4); 2.4942 (54.9); 2.3343 (0.7); 2.3301 (0.9); 2.3254 (0.7); 1.4499 (7.2); 1.4327 (7.1); 0.0079 (3.4); -0.0002 (90.1); -0.0084 (3.4) BCS241005-Ausland STR 158 I.1-260: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1303 (2.2); 9.1460 (3.0); 9.1295 (3.0); 8.6852 (4.8); 8.6792 (7.3); 8.6634 (7.5); 8.6574 (4.7); 8.0815 (7.2); 8.0609 (8.4); 8.0081 (5.6); 7.9878 (6.8); 7.8149 (14.0); 7.7944 (11.9); 5.3463 (1.8); 5.3295 (2.8); 5.3128 (1.8); 3.3416 (16.0); 2.5090 (59.4); 2.5050 (73.4); 2.5011 (54.8); 1.4734 (10.3); 1.4562 (10.1); -0.0002 (27.5) I.1-261: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6601 (2.7); 8.6541 (3.1); 8.5975 (3.1); 8.5928 (2.7); 8.2407 (4.0); 8.2207 (4.4); 8.0579 (0.6); 8.0008 (2.8); 7.9944 (3.0); 7.8404 (3.1); 7.7765 (4.6); 7.7558 (9.3); 7.5752 (3.1); 7.5187 (0.6); 7.4139 (1.0); 7.3937 (1.0); 7.2622 (80.2); 7.2603 (84.4); 6.9965 (0.6); 6.5034 (3.0); 5.7068 (1.1); 5.6904 (1.4); 5.6725 (1.0); 4.1315 (0.9); 4.1144 (1.0); 3.9745 (16.0); 2.8322 (0.8); 2.5836 (15.2); 2.0477 (3.9); 1.6731 (1.3); 1.4531 (6.8); 1.4359 (6.4); 1.2775 (1.4); 1.2597 (3.2); 1.2438 (1.2); 0.1473 (0.7); 0.0018 (117.6); -0.0002 (121.2); -0.1486 (0.6) I.1-262: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2592 (0.8); 9.2429 (0.8); 8.6978 (1.8); 8.6917 (2.8); 8.6702 (3.2); 8.6642 (2.2); 8.4604 (2.1); 8.4552 (2.1); 8.0971 (1.1); 8.0918 (1.1); 8.0774 (2.9); 8.0763 (3.1); 8.0726 (1.1); 8.0707 (1.6); 8.0610 (0.9); 8.0562 (3.2); 7.8716 (2.4); 7.8505 (2.1); 7.8082 (2.9); 7.8034 (0.9); 7.7917 (0.8); 7.7869 (2.6); 5.3260 (0.5); 5.3091 (0.8); 5.2921 (0.5); 3.8938 (11.2); 3.3322 (16.0); 2.5251 (1.4); 2.5205 (1.8); 2.5116 (25.2); 2.5071 (55.4); 2.5025 (76.9); 2.4980 (52.8); 2.4934 (23.0); 1.9898 (2.2); 1.4853 (3.1); 1.4681 (3.1); 1.1922 (0.6); 1.1745 (1.3); 1.1567 (0.6); 0.0080 (2.2); - 0.0002 (76.0); -0.0068 (0.5); -0.0085 (2.0) I.1-263: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2663 (0.8); 9.2500 (0.8); 8.7034 (1.9); 8.6973 (2.9); 8.6753 (3.2); 8.6692 (2.2); 8.1374 (2.1); 8.1163 (2.6); 8.1020 (2.3); 8.0977 (2.3); 8.0855 (2.7); 8.0808 (0.8); 8.0689 (0.9); 8.0642 (3.3); 7.9355 (1.5); 7.9310 (1.3); 7.9145 (1.2); 7.9099 (1.2); 7.8105 (3.1); 7.8056 (0.9); 7.7939 (0.9); 7.7892 (2.7); 5.3267 (0.5); 5.3098 (0.8); 5.2928 (0.5); 3.8966 (11.6); 3.3336 (16.0); 2.5257 (0.9); 2.5210 (1.1); 2.5121 (16.3); 2.5076 (35.6); 2.5031 (49.4); 2.4985 (34.0); 2.4939 (14.8); 1.9901 (1.4); 1.4892 (3.2); 1.4720 (3.2); 1.1747 (0.8); 0.0080 (1.3); -0.0002 (48.6); -0.0085 (1.4) I.1-264: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2784 (4.1); 9.2620 (4.3); 8.6902 (8.8); 8.6841 (14.2); 8.6669 (16.0); 8.6608 (10.4); 8.4877 (10.7); 8.4825 (10.8); 8.1122 (5.6); 8.1069 (5.2); 8.0911 (6.6); 8.0858 (6.6); 8.0677 (12.6); 8.0631 (4.2); 8.0512 (4.6); 8.0465 (15.4); 7.8747 (12.1); 7.8536 (10.4); 7.7910 (14.1); 7.7864 (4.4); 7.7744 (4.2); 7.7699 (12.4); 5.3475 (0.5); 5.3314 (2.6); 5.3145 (4.0); 5.2977 (2.6); 5.2804 (0.5); 4.0553 (0.6); 4.0374 (1.7); 4.0196 (1.8); 4.0018 (0.5); 3.5936 (0.7); 3.5834 (0.9); 3.5020 (1.1); 3.3878 (0.5); 3.3336 (9.5); 2.6761 (1.4); 2.6716 (2.0); 2.6671 (1.5); 2.5408 (1.1); 2.5363 (1.6); 2.5316 (2.2); 2.5255 (6.1); 2.5207 (8.8); 2.5118 (119.3); 2.5073 (257.9); 2.5028 (355.2); 2.4982 (246.1); 2.4937 (107.8); 2.4810 (0.8); 2.4762 (0.5); 2.4715 (0.6); 2.4669 (0.5); 2.3344 (1.5); 2.3299 (2.1); 2.3252 (1.4); 2.2420 (0.8); 1.9899 (8.2); 1.9095 (5.3); 1.4813 (15.4); 1.4641 (15.4); BCS241005-Ausland STR 159 1.2981 (0.8); 1.2582 (1.3); 1.2334 (1.8); 1.1923 (2.4); 1.1746 (4.7); 1.1568 (2.3); 1.0258 (0.7); 1.0101 (0.6); 0.8542 (0.9); 0.8357 (0.5); 0.1456 (0.9); 0.0378 (0.5); 0.0286 (1.0); 0.0080 (7.9); -0.0002 (272.8); -0.0085 (7.2); -0.1495 (0.9) I.1-265: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1286 (0.7); 9.2834 (0.6); 9.2669 (0.6); 8.6960 (1.2); 8.6898 (1.9); 8.6719 (2.2); 8.6658 (1.4); 8.1412 (1.4); 8.1229 (1.7); 8.1197 (2.6); 8.0746 (1.8); 8.0700 (0.6); 8.0580 (0.8); 8.0535 (2.2); 7.9484 (1.0); 7.9438 (0.8); 7.9275 (0.8); 7.9228 (0.8); 7.7925 (2.0); 7.7760 (0.6); 7.7714 (1.7); 5.3146 (0.6); 3.3348 (16.0); 2.5255 (0.9); 2.5208 (1.2); 2.5120 (15.1); 2.5075 (32.2); 2.5030 (43.9); 2.4984 (30.1); 2.4939 (13.0); 1.4857 (2.1); 1.4684 (2.1); 0.0080 (1.1); - 0.0002 (36.0); -0.0085 (1.0) I.1-266: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9907 (0.7); 8.9742 (0.7); 8.6867 (1.6); 8.6806 (2.4); 8.6569 (2.6); 8.6509 (1.9); 8.0889 (2.2); 8.0843 (0.8); 8.0723 (0.8); 8.0677 (2.8); 7.8203 (2.6); 7.8156 (0.8); 7.8037 (0.8); 7.7991 (2.3); 7.4376 (1.1); 7.4334 (1.7); 7.4296 (1.2); 7.2820 (1.0); 7.2785 (1.1); 7.2761 (1.3); 7.2726 (1.1); 7.1670 (1.1); 7.1616 (1.5); 7.1565 (1.0); 5.2849 (0.7); 3.8984 (9.6); 3.7959 (10.7); 3.3333 (16.0); 2.5252 (0.8); 2.5206 (1.2); 2.5117 (16.7); 2.5072 (35.9); 2.5027 (49.2); 2.4982 (34.3); 2.4936 (15.2); 1.4597 (2.8); 1.4424 (2.8); 0.0080 (1.0); -0.0002 (33.1); -0.0085 (1.0) I.1-267: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6798 (0.7); 8.6562 (0.8); 8.6501 (0.6); 8.0884 (0.7); 8.0671 (0.8); 7.8186 (0.8); 7.7973 (0.7); 7.5670 (0.6); 3.8989 (2.8); 3.7898 (3.2); 3.3318 (16.0); 2.5246 (0.7); 2.5199 (1.0); 2.5111 (14.6); 2.5066 (31.6); 2.5020 (43.6); 2.4974 (29.9); 2.4929 (13.0); 1.4578 (0.8); 1.4405 (0.8); 0.0080 (1.0); -0.0002 (31.9); -0.0085 (0.9) I.1-268: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1246 (1.3); 9.0052 (1.4); 8.9888 (1.5); 8.6800 (2.6); 8.6739 (3.6); 8.6540 (3.9); 8.6480 (2.6); 8.0753 (3.7); 8.0546 (4.4); 7.8011 (4.2); 7.7805 (3.7); 7.4562 (3.0); 7.4524 (1.9); 7.2974 (1.9); 7.2923 (2.3); 7.2887 (1.8); 7.1692 (1.9); 7.1642 (2.8); 7.1590 (1.6); 5.3086 (0.9); 5.2918 (1.4); 5.2748 (0.9); 3.8193 (0.5); 3.7993 (16.0); 3.3362 (12.1); 2.5076 (48.9); 2.5033 (61.9); 2.4990 (44.5); 1.4579 (5.0); 1.4407 (5.1); -0.0002 (20.5); -0.0084 (1.2) I.1-269: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1251 (1.0); 9.0146 (1.5); 8.9983 (1.5); 8.6799 (2.6); 8.6739 (3.7); 8.6540 (3.9); 8.6480 (2.6); 8.0767 (3.8); 8.0562 (4.5); 7.8022 (4.3); 7.7816 (3.8); 7.5993 (2.2); 7.5960 (3.2); 7.5926 (2.0); 7.3279 (1.8); 7.3228 (2.5); 7.3194 (2.0); 7.2914 (2.2); 7.2867 (2.7); 7.2816 (1.5); 5.3067 (0.9); 5.2899 (1.4); 5.2730 (0.9); 3.7942 (16.0); 3.3383 (11.8); 2.5080 (37.8); 2.5038 (47.6); 2.4994 (34.4); 1.4564 (5.1); 1.4393 (5.1); -0.0002 (15.3); -0.0083 (0.9) I.1-270: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6756 (1.9); 8.6548 (1.2); 8.2316 (1.6); 8.1276 (1.4); 8.1083 (1.6); 7.7193 (0.7); 7.6879 (1.0); 7.6500 (0.6); 7.6314 (0.6); 7.5821 (1.0); 7.5412 (1.0); 7.3744 BCS241005-Ausland STR 160 (2.7); 7.2634 (13.6); 4.1492 (1.0); 4.1313 (2.9); 4.1135 (2.9); 4.0957 (1.0); 4.0652 (0.8); 3.9852 (16.0); 2.0477 (14.6); 1.5872 (7.9); 1.4429 (1.6); 1.4284 (1.8); 1.3921 (0.6); 1.3726 (0.6); 1.3346 (1.3); 1.2784 (3.4); 1.2605 (6.5); 1.2427 (3.3); 0.9544 (0.6); 0.9359 (1.2); 0.9175 (0.5); -0.0002 (16.9); -0.0084 (1.0) I.1-271: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6655 (2.0); 8.6430 (1.3); 8.2274 (1.8); 8.1224 (1.3); 8.1043 (1.5); 8.0782 (0.8); 8.0437 (1.1); 7.6630 (1.3); 7.6454 (1.3); 7.5271 (3.2); 7.5064 (2.4); 7.2632 (15.5); 7.1280 (0.5); 5.2051 (0.6); 4.1492 (0.8); 4.1314 (2.4); 4.1136 (2.4); 4.0957 (0.9); 4.0821 (0.6); 4.0653 (1.0); 4.0485 (0.6); 3.9832 (16.0); 2.0479 (12.9); 1.6106 (0.6); 1.5801 (11.4); 1.4373 (1.9); 1.4215 (2.0); 1.3915 (0.9); 1.3723 (0.8); 1.3544 (0.8); 1.3325 (1.4); 1.2785 (2.8); 1.2606 (5.4); 1.2428 (2.7); 0.9543 (0.8); 0.9360 (1.5); 0.9175 (0.7); -0.0002 (19.2) I.1-272: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6548 (2.6); 8.6488 (3.3); 8.6049 (2.8); 8.5988 (2.2); 8.2659 (3.4); 8.2540 (0.6); 8.2497 (3.1); 8.2450 (1.1); 8.2331 (1.1); 8.2285 (3.6); 8.2243 (0.6); 8.0270 (1.5); 7.7837 (3.4); 7.7790 (1.1); 7.7671 (1.1); 7.7625 (3.2); 7.3327 (0.6); 7.3122 (0.6); 7.2610 (26.7); 5.6494 (0.7); 5.6295 (0.6); 3.9773 (16.0); 1.8154 (0.8); 1.7985 (1.2); 1.7802 (1.5); 1.7617 (0.9); 1.5641 5 (5.5); 1.2651 (0.9); 0.8820 (1.6); 0.8643 (0.6); 0.7725 (2.6); 0.7540 (5.7); 0.7354 (2.4); 0.0079 (1.1); - 0.0002 (32.4); -0.0085 (1.0) I.1-274: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6986 (2.6); 8.6926 (3.2); 8.6459 (2.9); 8.6398 (2.3); 8.2522 (3.7); 8.2401 (0.6); 8.2358 (3.3); 8.2313 (1.1); 8.2194 (1.2); 8.2147 (3.6); 8.0224 (1.6); 7.7432 10 (3.6); 7.7387 (1.2); 7.7267 (1.1); 7.7222 (3.3); 7.6153 (0.6); 7.5962 (0.6); 7.2626 (20.0); 6.1370 (0.6); 6.1205 (1.0); 6.1013 (0.7); 5.9777 (0.6); 5.9617 (0.5); 5.9523 (0.7); 5.9356 (1.1); 5.9190 (0.6); 5.9096 (0.8); 5.8936 (0.6); 5.2627 (1.5); 5.2374 (1.4); 5.0457 (1.3); 5.0029 (1.2); 3.9806 (16.0); 1.6175 (1.0); 0.0080 (0.6); -0.0002 (17.0) 15 I.1-275: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6499 (2.9); 8.6440 (3.4); 8.6077 (3.4); 8.6018 (2.5); 8.2834 (5.4); 8.2595 (3.9); 8.2388 (4.2); 8.0386 (2.3); 7.8164 (4.2); 7.7957 (3.8); 7.2949 (1.0); 7.2624 (18.2); 5.6041 (1.0); 5.5844 (1.5); 5.5621 (1.1); 3.9778 (16.0); 2.0263 (0.6); 2.0095 (0.9); 1.9917 (0.9); 1.9744 (0.6); 1.5803 (9.6); 1.2637 (0.9); 0.8963 (6.7); 0.8796 (6.7); 0.8643 (0.7); 0.6207 (6.0); 0.6038 (5.9); -0.0002 (21.7); -0.0082 (1.2) 20 I.1-276: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6378 (2.2); 8.6318 (2.7); 8.5964 (2.7); 8.5905 (2.0); 8.2490 (3.1); 8.2283 (3.3); 7.8097 (3.4); 7.7891 (3.1); 7.7391 (2.4); 7.6070 (1.9); 7.3927 (1.8); 7.2640 (6.5); 7.1945 (0.9); 7.1718 (0.9); 5.5607 (0.9); 5.5410 (1.2); 5.5187 (0.9); 3.9737 (12.5); 2.1749 (16.0); 1.9734 (0.8); 1.9558 (0.8); 1.9384 (0.5); 1.6156 (0.6); 0.8720 (5.2); 0.8552 (5.0); 0.6067 (5.0); 0.5898 25 (4.8); -0.0002 (7.9) BCS241005-Ausland STR 161 I.1-277: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6317 (1.3); 8.6258 (1.6); 8.5961 (1.6); 8.5902 (1.2); 8.2457 (1.8); 8.2250 (2.0); 7.8072 (2.0); 7.7865 (1.8); 7.7085 (3.1); 7.7039 (3.0); 7.5153 (0.9); 7.5108 (1.4); 7.5063 (0.8); 7.2665 (2.4); 5.5462 (0.5); 5.5265 (0.7); 5.5040 (0.5); 3.9726 (7.7); 2.1745 (16.0); 1.6521 (1.0); 0.8704 (3.0); 0.8536 (3.0); 0.6000 (2.9); 0.5831 (2.9); -0.0002 (2.9) 5 I.1-278: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6763 (2.8); 8.6703 (3.2); 8.6247 (3.2); 8.6188 (2.6); 8.2208 (3.9); 8.2002 (4.2); 7.9075 (3.0); 7.9026 (2.9); 7.7362 (4.2); 7.7155 (3.8); 7.6570 (1.4); 7.6520 (1.2); 7.6363 (1.9); 7.6313 (1.7); 7.5340 (3.2); 7.5132 (2.3); 7.4662 (1.0); 7.4472 (1.1); 7.2619 (24.8); 6.1029 (0.8); 6.0868 (1.3); 6.0680 (0.9); 5.9446 (0.7); 5.9289 (0.6); 5.9190 (0.8); 5.9026 (1.2); 5.8862 10 (0.7); 5.8762 (0.8); 5.8606 (0.7); 5.2225 (1.9); 5.1975 (1.8); 5.0151 (1.8); 4.9725 (1.6); 3.9751 (16.0); 2.1748 (0.9); 1.5626 (1.3); 1.2641 (2.1); 0.8985 (1.0); 0.8820 (2.4); 0.8641 (1.1); -0.0002 (30.8) I.1-279: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6790 (2.7); 8.6730 (3.3); 8.6365 (3.3); 8.6305 (2.5); 8.2220 (3.7); 8.2012 (4.0); 8.0025 (2.0); 7.9989 (3.2); 7.9952 (1.8); 7.8433 (1.8); 7.8391 (2.8); 7.8350 15 (1.7); 7.7403 (2.2); 7.7360 (3.8); 7.7315 (5.4); 7.7103 (3.6); 7.4128 (0.9); 7.3935 (0.9); 7.2616 (45.6); 6.0831 (0.7); 6.0663 (1.2); 6.0476 (0.8); 5.9433 (0.7); 5.9278 (0.6); 5.9179 (0.8); 5.9012 (1.1); 5.8851 (0.7); 5.8752 (0.8); 5.8593 (0.7); 5.2294 (1.7); 5.2035 (1.6); 5.0191 (1.6); 4.9754 (1.5); 3.9754 (16.0); 1.5542 (3.4); 1.2642 (1.6); 0.8987 (0.7); 0.8820 (2.0); 0.8643 (0.9); -0.0002 (56.8); -0.0084 (3.2) 20 I.1-280: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6861 (2.8); 8.6802 (3.3); 8.6362 (3.3); 8.6303 (2.6); 8.2244 (3.9); 8.2039 (4.3); 7.7322 (4.3); 7.7115 (5.9); 7.5687 (2.3); 7.4930 (1.1); 7.4734 (1.2); 7.3781 (2.2); 7.2616 (37.7); 6.0961 (0.8); 6.0787 (1.4); 6.0607 (1.0); 5.9445 (0.7); 5.9287 (0.6); 5.9188 (0.8); 5.9022 (1.3); 5.8856 (0.7); 5.8761 (0.9); 5.8603 (0.7); 5.2343 (2.0); 5.2086 (1.9); 5.0216 (1.9); 4.9782 (1.7); 3.9767 (16.0); 1.5599 (1.9); 1.2639 (2.0); 0.8985 (0.9); 0.8818 (2.2); 0.8644 (1.0); -0.0002 (46.9) 25 I.1-281: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6797 (2.9); 8.6741 (3.3); 8.6365 (3.5); 8.6305 (2.5); 8.2219 (4.1); 8.2014 (4.4); 7.8623 (6.3); 7.8584 (6.7); 7.8020 (3.1); 7.7301 (4.4); 7.7097 (4.0); 7.4276 (1.2); 7.4080 (1.2); 7.2618 (28.6); 6.0848 (0.9); 6.0667 (1.5); 6.0482 (1.0); 5.9428 (0.7); 5.9271 (0.6); 5.9171 (0.8); 5.9003 (1.3); 5.8839 (0.7); 5.8739 (0.8); 5.8588 (0.7); 5.2288 (2.1); 5.2035 (2.0); 5.018930 (2.0); 4.9763 (1.8); 3.9756 (16.0); 1.5569 (2.7); 1.2633 (1.8); 0.8974 (0.8); 0.8816 (1.9); 0.8642 (0.9); - 0.0002 (35.4) I.1-282: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6350 (2.8); 8.6291 (3.3); 8.5867 (3.1); 8.5808 (2.4); 8.2364 (3.5); 8.2153 (4.0); 7.9251 (2.8); 7.9201 (2.8); 7.7790 (3.9); 7.7581 (3.6); 7.6709 (1.4); 7.6658 35 (1.2); 7.6501 (1.9); 7.6450 (1.7); 7.5441 (3.0); 7.5232 (2.3); 7.2621 (26.5); 7.1988 (0.9); 7.1783 (0.9); 5.6070 (1.0); 5.5887 (0.9); 3.9726 (16.0); 1.7756 (0.9); 1.7586 (1.0); 1.7501 (0.9); 1.7408 (0.8); 1.7315 (1.2); 1.7130 (0.9); 1.5657 (3.8); 0.7438 (3.0); 0.7253 (6.4); 0.7068 (2.9); -0.0002 (32.5); -0.0084 (1.7) BCS241005-Ausland STR 162 I.1-283: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6335 (2.8); 8.6276 (3.3); 8.5794 (3.2); 8.5734 (2.6); 8.2246 (3.8); 8.2040 (4.3); 7.9381 (3.0); 7.9331 (2.9); 7.8324 (4.3); 7.8118 (3.9); 7.6832 (1.4); 7.6782 (1.3); 7.6625 (1.9); 7.6574 (1.7); 7.5471 (3.2); 7.5264 (2.4); 7.2870 (1.1); 7.2625 (16.0); 5.1297 (1.1); 5 5.1087 (2.1); 5.0878 (1.2); 3.9697 (16.0); 1.5763 (1.3); 1.3027 (0.5); 1.2635 (2.2); 1.1385 (0.8); 1.1259 (0.7); 1.1182 (0.9); 1.1052 (0.5); 0.8982 (1.0); 0.8817 (2.6); 0.8640 (1.2); 0.5030 (0.6); 0.4981 (0.6); 0.4821 (0.8); 0.4741 (0.8); 0.3501 (0.7); 0.3296 (1.4); 0.3205 (2.0); 0.3073 (1.5); 0.2978 (0.7); -0.0002 (18.9); -0.0593 (0.6); -0.0698 (0.9); -0.0837 (1.1); -0.0963 (0.6) 10 I.1-285: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6458 (2.8); 8.6398 (3.4); 8.5983 (3.2); 8.5923 (2.6); 8.2402 (3.7); 8.2195 (4.1); 7.7741 (4.1); 7.7535 (3.7); 7.7275 (1.9); 7.7235 (3.0); 7.7196 (1.8); 7.5870 (2.0); 7.3837 (1.9); 7.2621 (24.2); 7.2290 (1.0); 7.2089 (1.0); 5.6065 (1.0); 5.5881 (0.9); 5.5695 (0.5); 3.9744 (16.0); 1.7836 (0.9); 1.7652 (1.0); 1.7589 (0.9); 1.7488 (0.9); 1.7403 (1.3); 1.7221 (1.0); 1.7053 (0.5); 1.5677 (1.4); 1.2639 (1.0); 0.8818 (1.2); 0.8643 (0.6); 0.7515 (3.1); 0.7330 (6.6); 0.7145 (3.0); - 15 0.0002 (29.4); -0.0080 (1.8) I.1-287: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6401 (3.0); 8.6368 (3.4); 8.5894 (3.5); 8.2271 (4.3); 8.2075 (4.7); 7.8232 (4.8); 7.8041 (4.4); 7.7395 (3.7); 7.5964 (3.1); 7.3869 (2.9); 7.2995 (1.6); 7.2781 (2.1); 7.2619 (30.0); 7.2599 (29.1); 5.1251 (1.4); 5.1049 (2.5); 5.0838 (1.3); 3.9714 (16.0); 1.5642 (4.1); 20 1.2639 (2.1); 1.1454 (1.1); 1.1251 (1.1); 0.8962 (0.9); 0.8819 (1.9); 0.8641 (1.0); 0.5172 (1.0); 0.4926 (1.2); 0.4736 (0.7); 0.3383 (2.2); 0.3261 (2.3); 0.3150 (1.9); 0.3016 (0.9); -0.0002 (37.4); -0.0022 (35.5); -0.0600 (1.0); -0.0724 (1.2); -0.0827 (1.4) I.1-288: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6455 (2.7); 8.6395 (3.3); 8.5939 (3.1); 8.5879 (2.5); 25 8.2404 (3.6); 8.2361 (1.3); 8.2195 (3.9); 7.7749 (3.9); 7.7705 (1.4); 7.7541 (3.6); 7.4930 (3.1); 7.4880 (2.9); 7.4740 (1.1); 7.4700 (1.1); 7.2620 (28.7); 7.2455 (1.2); 7.2247 (1.0); 7.1311 (0.9); 7.1097 (0.9); 5.6113 (0.9); 5.5931 (0.9); 3.9745 (16.0); 1.7817 (0.9); 1.7657 (0.9); 1.7540 (0.9); 1.7472 (0.8); 1.7357 (1.2); 1.7173 (0.9); 1.7010 (0.6); 1.5691 (1.2); 0.7501 (3.0); 0.7316 (6.3); 0.7130 (2.8); -0.0002 (35.0); - 0.0084 (1.8) 30 I.1-289: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6416 (2.9); 8.6357 (3.3); 8.5868 (3.2); 8.5808 (2.5); 8.2289 (3.6); 8.2081 (4.1); 7.8258 (4.0); 7.8050 (3.7); 7.5052 (3.2); 7.5001 (3.1); 7.4867 (1.2); 7.4816 (1.2); 7.3109 (0.9); 7.2919 (1.0); 7.2624 (16.2); 7.1348 (0.9); 7.1133 (1.0); 5.1374 (1.0); 5.1164 (1.9); 5.0955 (1.0); 3.9717 (16.0); 1.5790 (1.4); 1.1413 (0.8); 1.1337 (0.6); 1.1286 (0.6); 1.1207 (0.8); 0.5117 35 (0.5); 0.5052 (0.5); 0.4903 (0.8); 0.4855 (0.7); 0.4815 (0.7); 0.3552 (0.6); 0.3412 (1.1); 0.3347 (1.3); 0.3260 (1.8); 0.3154 (1.3); 0.3124 (1.3); 0.3033 (0.6); -0.0002 (19.7); -0.0083 (1.1); -0.0596 (0.5); - 0.0715 (0.8); -0.0856 (0.9); -0.0982 (0.5) BCS241005-Ausland STR 163 I.1-290: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6499 (2.7); 8.6439 (3.3); 8.5994 (3.1); 8.5934 (2.5); 8.2406 (3.6); 8.2198 (4.0); 7.8766 (2.1); 7.8729 (3.2); 7.8692 (1.8); 7.7773 (4.0); 7.7564 (3.7); 7.6311 (2.0); 7.5334 (1.8); 7.2623 (18.9); 7.2513 (1.2); 7.2289 (1.0); 5.6014 (0.9); 5.5832 (0.9); 3.9741 (16.0); 5 1.7855 (1.0); 1.7663 (1.5); 1.7472 (1.5); 1.7290 (1.0); 1.7122 (0.6); 1.3033 (0.6); 1.2642 (2.6); 0.8986 (1.2); 0.8819 (3.3); 0.8642 (1.5); 0.7543 (3.0); 0.7358 (6.4); 0.7172 (2.9); -0.0002 (23.0); -0.0083 (1.2) I.1-291: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6434 (2.8); 8.6374 (3.4); 8.5921 (3.2); 8.5861 (2.6); 8.2283 (3.7); 8.2075 (4.1); 7.8911 (1.9); 7.8874 (3.0); 7.8837 (1.8); 7.8262 (4.1); 7.8054 (3.7); 7.6403 10 (2.0); 7.5380 (1.9); 7.3047 (0.9); 7.2849 (0.9); 7.2626 (13.3); 5.1183 (1.0); 5.0975 (1.9); 5.0766 (1.1); 3.9714 (16.0); 1.5846 (0.6); 1.2638 (1.2); 1.1485 (0.7); 1.1406 (0.5); 1.1359 (0.6); 1.1279 (0.8); 0.8986 (0.5); 0.8818 (1.5); 0.8642 (0.7); 0.5203 (0.5); 0.4985 (0.8); 0.4941 (0.7); 0.4888 (0.7); 0.3489 (0.7); 0.3388 (1.5); 0.3261 (1.4); 0.3155 (1.2); 0.3023 (0.7); -0.0002 (16.1); -0.0083 (1.0); -0.0590 (0.6); - 0.0705 (0.8); -0.0824 (0.9); -0.0926 (0.5) 15 I.1-294: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7139 (5.7); 8.6843 (2.2); 8.2618 (1.9); 8.1888 (1.4); 8.1213 (2.1); 7.7724 (2.3); 7.7476 (2.2); 7.6677 (1.3); 7.6484 (1.4); 7.6292 (1.7); 7.5925 (2.0); 7.5211 (1.9); 7.3974 (4.0); 7.2626 (39.8); 5.4229 (0.7); 5.3368 (0.9); 5.3023 (2.1); 3.7746 (6.2); 3.7589 (14.6); 3.7428 (6.7); 3.6616 (0.6); 2.1332 (3.8); 1.8942 (0.8); 1.8770 (6.1); 1.8686 (7.7); 1.8610 (16.0); 1.8525 20 (7.9); 1.8448 (6.3); 1.8279 (1.2); 1.5122 (3.2); 1.4960 (3.5); 1.4315 (1.6); 1.4130 (2.7); 1.4001 (2.7); 1.2560 (0.7); 0.9406 (0.5); -0.0002 (46.5) I.1-295: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7051 (3.8); 8.6767 (1.6); 8.2514 (1.3); 8.1713 (1.0); 8.1362 (1.6); 8.1038 (2.3); 8.0809 (1.0); 7.7458 (1.3); 7.7123 (0.9); 7.6607 (0.9); 7.6399 (0.8); 7.5525 25 (2.3); 7.5314 (2.2); 7.5013 (1.2); 7.2629 (26.2); 5.3567 (0.6); 5.3022 (4.3); 3.7745 (5.9); 3.7584 (14.4); 3.7422 (6.2); 2.1299 (2.8); 1.8937 (0.7); 1.8769 (6.0); 1.8689 (7.4); 1.8607 (16.0); 1.8522 (7.2); 1.8444 (6.0); 1.8273 (1.0); 1.5122 (2.2); 1.4957 (2.4); 1.4323 (1.4); 1.4200 (1.9); 1.4039 (1.8); -0.0002 (31.2); - 0.0082 (1.9) 30 I.1-296: 1H-NMR (400.6 MHz, CDCl3): δ= 9.3019 (0.6); 9.2846 (0.6); 8.7160 (1.0); 8.7100 (1.6); 8.6936 (1.7); 8.6876 (1.0); 8.1569 (1.3); 8.1520 (1.2); 8.0888 (1.6); 8.0681 (1.8); 7.8356 (1.0); 7.8147 (1.4); 7.7859 (1.8); 7.7653 (1.6); 7.7143 (0.8); 7.7092 (0.7); 7.6934 (0.6); 7.6884 (0.6); 6.1336 (0.5); 5.8628 (0.6); 5.2150 (0.7); 5.1894 (0.7); 4.9703 (0.7); 4.9273 (0.6); 3.9006 (5.8); 3.3340 (16.0); 2.5073 (27.5); 2.5030 (35.3); 2.4986 (25.4); 2.4944 (12.6); -0.0002 (12.0); -0.0083 (0.7) 35 BCS241005-Ausland STR 164 I.1-297: 1H-NMR (400.6 MHz, d6-DMSO): δ= 9.0595 (0.8); 9.0442 (0.8); 8.7244 (1.8); 8.6875 (1.2); 8.6818 (1.8); 8.1326 (1.7); 8.1159 (1.8); 7.8280 (2.0); 7.8110 (1.7); 7.7789 (1.0); 7.7589 (1.0); 7.3282 (0.5); 7.3083 (1.0); 7.2892 (0.6); 7.1707 (1.1); 7.1519 (0.9); 5.2457 (0.7); 3.9677 (0.5); 3.9105 (5.0); 3.9069 (5.4); 3.3903 (1.6); 3.3325 (15.3); 3.3288 (16.0); 2.5578 (9.0); 2.5017 (70.2); 2.4977 (72.8); 5 1.4403 (2.6); 1.4238 (2.4); 0.0568 (0.9); -0.0002 (9.2); -0.0042 (9.1) I.1-298: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1565 (2.2); 9.0641 (2.1); 9.0468 (2.2); 8.7250 (4.0); 8.7190 (5.1); 8.6854 (5.4); 8.6794 (4.2); 8.1151 (5.6); 8.0945 (6.5); 7.8045 (6.3); 7.7840 (8.0); 7.7640 (3.0); 7.7604 (2.7); 7.3334 (2.0); 7.3142 (4.0); 7.2946 (2.4); 7.1797 (2.8); 7.1760 (2.7); 7.1609 (2.4); 10 7.1573 (2.1); 5.2784 (1.3); 5.2612 (2.1); 5.2442 (1.4); 3.3439 (16.0); 2.5078 (45.9); 2.5035 (58.6); 2.4992 (42.2); 1.4459 (7.6); 1.4290 (7.7); -0.0002 (11.2); -0.0083 (0.6) I.1-299: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1303 (2.9); 9.1450 (3.6); 9.1300 (3.8); 8.6797 (7.4); 8.6633 (7.2); 8.0807 (7.3); 8.0617 (8.7); 8.0073 (7.1); 7.9879 (8.3); 7.8145 (16.0); 7.7951 (14.6); 5.3453 15 (2.2); 5.3294 (3.2); 5.3128 (2.4); 3.3416 (12.4); 2.6738 (0.7); 2.5052 (83.7); 2.3328 (1.0); 1.4725 (11.4); 1.4568 (11.5); 1.2425 (6.2); 0.8571 (4.3); 0.8404 (2.4); -0.0002 (5.1) I.1-300: 1H-NMR (400.6 MHz, d6-DMSO): δ= 9.0703 (0.6); 9.0533 (0.5); 8.7341 (1.0); 8.7284 (1.1); 8.6895 (1.2); 8.6837 (0.9); 8.1316 (1.4); 8.1113 (1.6); 7.8311 (1.5); 7.8107 (1.4); 7.5417 (1.5); 7.5275 20 (0.9); 7.5218 (0.8); 7.2551 (1.1); 7.2496 (1.0); 5.2864 (0.5); 3.9089 (4.9); 3.3326 (16.0); 2.5053 (40.3); 2.5019 (49.7); 1.4565 (2.0); 1.4396 (2.0); -0.0002 (9.8) I.1-301: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1464 (0.9); 9.0805 (0.7); 9.0632 (0.8); 8.7296 (1.6); 8.7235 (1.9); 8.6871 (2.1); 8.6810 (1.7); 8.1104 (2.0); 8.0893 (2.3); 7.8046 (2.3); 7.7835 (2.0); 7.5673 25 (0.7); 7.5461 (2.4); 7.5310 (1.6); 7.5253 (1.5); 7.5097 (0.5); 7.5040 (0.6); 7.2957 (1.7); 7.2901 (1.6); 5.2866 (0.7); 5.2693 (0.5); 3.3382 (16.0); 2.5115 (19.6); 2.5072 (37.4); 2.5027 (48.2); 2.4982 (35.6); 2.4939 (19.1); 1.4539 (2.6); 1.4369 (2.7); -0.0002 (9.0); -0.0085 (0.7) I.1-302: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6569 (2.7); 8.6509 (3.2); 8.6033 (3.1); 8.5973 (2.5); 30 8.2327 (3.7); 8.2120 (4.0); 7.7876 (11.4); 7.7313 (4.0); 7.7106 (3.7); 7.3260 (0.8); 7.3062 (0.9); 7.2624 (16.0); 5.6514 (0.9); 5.6340 (1.1); 5.6153 (0.9); 3.9749 (16.0); 1.5730 (11.3); 1.4086 (6.1); 1.3919 (6.2); -0.0002 (19.8); -0.0083 (1.1) I.1-303: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1964 (1.7); 9.1803 (1.8); 8.6607 (2.6); 8.6551 (4.6); 35 8.6464 (4.7); 8.6405 (2.3); 8.0330 (4.3); 8.0123 (16.0); 7.6966 (4.2); 7.6764 (3.8); 5.3359 (1.0); 5.3191 (1.6); 5.3025 (1.0); 2.5079 (55.0); 2.5042 (65.0); 2.3311 (0.6); 1.4585 (5.7); 1.4414 (5.8); -0.0002 (27.6) BCS241005-Ausland STR 165 I.1-304: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6327 (2.5); 8.6267 (3.5); 8.6047 (3.3); 8.5987 (2.2); 8.2279 (3.6); 8.2235 (1.3); 8.2111 (1.7); 8.2071 (3.9); 7.8289 (0.5); 7.8048 (0.8); 7.8006 (0.9); 7.7964 (0.6); 7.7846 (1.2); 7.7805 (1.2); 7.7765 (0.6); 7.7686 (0.6); 7.7644 (0.8); 7.7602 (0.6); 7.7470 (4.1); 7.7426 (1.5); 7.7262 (3.6); 7.3221 (0.7); 7.3181 (0.9); 7.3025 (0.6); 7.2982 (1.0); 7.2941 (0.7); 7.2785 5 (0.5); 7.2740 (0.5); 7.2640 (6.1); 7.2061 (0.5); 7.2026 (0.5); 7.1942 (0.6); 7.1908 (0.6); 7.1859 (0.8); 7.1824 (0.8); 7.1741 (0.8); 7.1708 (0.8); 5.7139 (0.5); 5.7095 (0.6); 5.6931 (0.8); 5.6785 (0.6); 5.3016 (1.4); 3.9721 (16.0); 1.5962 (3.2); 1.4401 (6.3); 1.4234 (6.4); -0.0002 (7.5) I.1-305: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6471 (2.8); 8.6412 (3.2); 8.5890 (3.1); 8.5831 (2.6); 10 8.2302 (3.8); 8.2095 (4.1); 7.7408 (4.1); 7.7201 (3.8); 7.6355 (1.4); 7.6309 (1.4); 7.6120 (1.4); 7.6074 (1.5); 7.5517 (1.0); 7.5471 (0.9); 7.5307 (1.9); 7.5262 (1.7); 7.4946 (1.8); 7.4772 (1.9); 7.4567 (1.0); 7.3575 (0.9); 7.3380 (0.9); 7.2638 (6.3); 5.6742 (0.9); 5.6566 (1.2); 5.6383 (0.9); 3.9732 (16.0); 1.6134 (3.2); 1.4053 (6.4); 1.3886 (6.4); -0.0002 (7.7) I.1-306: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.5061 (1.2); 9.4897 (1.2); 8.8287 (1.6); 8.8238 (2.3); 8.8196 (1.7); 8.7237 (1.8); 8.7198 (2.6); 8.7145 (2.5); 8.7121 (3.0); 8.7059 (3.6); 8.7002 (2.4); 8.6965 (3.1); 8.6792 (3.4); 8.6731 (2.5); 8.0703 (3.2); 8.0494 (3.9); 7.8164 (3.7); 7.7955 (3.2); 5.3916 (0.8); 5.3747 (1.1); 5.3579 (0.8); 3.8854 (12.4); 3.3346 (16.0); 2.7120 (13.1); 2.5077 (35.3); 2.5033 (45.2); 2.4989 (33.1); 1.9902 (1.0); 1.5314 (4.3); 1.5143 (4.3); 1.1748 (0.6); -0.0002 (11.4); -0.0084 (0.7) I.1-307: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1124 (0.8); 9.5247 (0.5); 9.5082 (0.6); 8.8556 (0.7); 8.8510 (1.1); 8.8466 (0.7); 8.7199 (1.8); 8.7158 (2.2); 8.7044 (1.2); 8.6983 (1.5); 8.6762 (1.5); 8.6702 (1.1); 8.0594 (1.4); 8.0387 (1.6); 7.8001 (1.6); 7.7794 (1.4); 5.3788 (0.5); 3.3328 (16.0); 2.7139 (5.6); 2.6713 (0.6); 2.5105 (39.6); 2.5066 (74.1); 2.5022 (94.4); 2.4978 (67.7); 2.4937 (33.6); 2.3292 (0.7); 1.5275 (1.8); 1.5101 (1.9); -0.0002 (39.8); - 0.0083 (2.4) I.1-308: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7101 (0.6); 8.6941 (0.6); 8.0881 (0.6); 8.0675 (0.7); 8.0209 (0.5); 7.8322 (0.5); 7.7861 (0.7); 7.7654 (0.6); 3.8992 (2.3); 3.3341 (16.0); 2.5069 (20.2); 2.5025 (25.7); 2.4982 (18.5); -0.0002 (4.3) I.1-309: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1416 (3.2); 9.3135 (6.1); 9.2952 (6.1); 8.7053 (13.8); 8.6870 (13.2); 8.0704 (13.7); 8.0539 (16.0); 8.0391 (14.9); 7.8559 (7.3); 7.8351 (9.0); 7.7631 (14.8); 7.7460 (13.3); 7.6921 (8.2); 7.6711 (6.3); 6.1477 (2.5); 6.1246 (3.8); 6.1063 (2.8); 6.0814 (2.1); 5.8838 (3.7); 5.8696 (6.8); 5.8526 (3.3); 5.2150 (7.0); BCS241005-Ausland STR 166 5.1892 (6.5); 4.9624 (6.9); 4.9194 (6.0); 3.4110 (10.5); 2.6715 (11.1); 2.5022 (847.6); 2.4984 (832.3); 2.3295 (9.9); 0.1413 (2.0); -0.0002 (208.5); -0.0044 (203.9) I.1-310: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1369 (2.9); 9.0542 (4.8); 9.0382 (4.9); 8.6823 (7.9); 8.6770 (10.0); 8.6590 (10.6); 8.6543 (7.1); 8.0733 (10.8); 8.0531 (12.3); 7.8336 (5.4); 7.7988 (13.4); 7.7785 (11.0); 7.7092 (2.1); 7.6870 (14.6); 7.6711 (6.2); 7.6502 (2.0); 5.3178 (2.9); 5.3013 (4.3); 5.2846 (3.0); 5.2665 (0.9); 3.3429 (5.5); 2.6748 (0.6); 2.5061 (94.4); 2.3331 (1.0); 1.4655 (16.0); 1.4485 (15.9); -0.0002 (30.1) I.1-311: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6339 (2.6); 8.6280 (3.3); 8.5948 (3.2); 8.5888 (2.4); 8.2284 (3.7); 8.2075 (4.1); 8.1663 (2.3); 8.1478 (2.3); 7.8453 (0.5); 7.8372 (0.5); 7.7312 (4.0); 7.7103 (3.7); 7.3162 (2.4); 7.2892 (2.4); 7.2638 (6.8); 5.6802 (0.5); 5.6759 (0.6); 5.6591 (0.8); 5.6450 (0.6); 3.9734 (16.0); 1.5903 (3.5); 1.4287 (6.3); 1.4120 (6.3); -0.0002 (7.8) I.1-312: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.2028 (0.5); 8.9928 (4.2); 8.9762 (4.1); 8.7193 (7.3); 8.7161 (9.0); 8.6901 (8.9); 8.6876 (8.9); 8.6844 (6.9); 8.0975 (10.4); 8.0788 (11.7); 7.7875 (11.3); 7.7684 (10.3); 7.5599 (1.3); 7.5442 (2.1); 7.5363 (2.5); 7.5191 (2.6); 7.5012 (1.0); 7.2753 (1.8); 7.2527 (8.0); 7.2442 (5.9); 7.2262 (2.9); 7.2064 (0.8); 5.3276 (0.9); 5.3112 (3.0); 5.2944 (4.2); 5.2779 (2.8); 5.2617 (0.7); 3.3447 (1.5); 2.6701 (1.6); 2.5048 (87.9); 2.5017 (83.6); 1.4352 (16.0); 1.4185 (15.3); -0.0002 (15.9); -0.0028 (14.5) I.1-313: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1539 (2.9); 9.0129 (4.3); 8.9963 (4.1); 8.7275 (7.4); 8.7245 (8.7); 8.6943 (8.9); 8.0960 (10.9); 8.0777 (11.5); 7.8755 (1.0); 7.8604 (1.0); 7.8344 (1.2); 7.7923 (8.1); 7.7813 (12.8); 7.7678 (10.1); 7.7631 (11.0); 7.6563 (6.4); 7.6399 (6.2); 5.3270 (1.0); 5.3100 (2.9); 5.2932 (4.2); 5.2763 (2.7); 5.2589 (0.7); 3.3413 (14.0); 2.6729 (1.9); 2.5083 (101.9); 2.5046 (99.8); 2.3310 (0.6); 1.4406 (16.0); 1.4237 (15.3); 1.3570 (2.2); 1.2732 (0.7); 1.2359 (0.6); 1.1829 (1.8); 1.1725 (1.8); 0.0032 (16.4); -0.0002 (17.7) I.1-314: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6380 (2.5); 8.6321 (3.5); 8.6110 (3.5); 8.6051 (2.3); 8.2255 (3.8); 8.2048 (4.2); 7.9242 (1.3); 7.9034 (2.1); 7.8833 (1.8); 7.8655 (0.7); 7.7338 (4.1); 7.7131 (3.9); 7.3849 (1.7); 7.3814 (1.6); 7.3632 (1.6); 7.3598 (1.5); 7.2635 (7.6); 5.6965 (0.6); 5.6919 (0.6); 5.6779 (0.9); 5.6612 (0.7); 5.3017 (0.7); 3.9719 (16.0); 1.5844 (4.8); 1.4328 (6.5); 1.4161 (6.5); -0.0002 (8.4) BCS241005-Ausland STR 167 I.1-315: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6581 (2.0); 8.6522 (2.3); 8.6008 (2.3); 8.5949 (1.8); 8.2330 (2.7); 8.2122 (3.0); 7.7301 (3.0); 7.7146 (3.0); 7.7100 (3.5); 7.5474 (1.2); 7.5427 (1.0); 7.5256 (1.2); 7.5209 (1.1); 7.3463 (0.6); 7.3272 (0.7); 7.2620 (21.1); 5.6560 (0.7); 5.6382 (0.9); 5.6201 (0.7); 3.9753 (11.6); 1.5625 (16.0); 1.4056 (4.6); 1.3889 (4.6); -0.0002 (23.3); -0.0083 (1.3) I.1-318: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6850 (7.9); 8.6790 (9.0); 8.6284 (8.9); 8.6225 (7.2); 8.4437 (7.9); 8.2739 (4.2); 8.2543 (4.5); 8.0849 (3.9); 8.0657 (4.2); 7.7756 (8.5); 7.7245 (3.8); 7.7051 (6.6); 7.6857 (3.3); 7.6289 (6.4); 7.4981 (3.9); 7.4755 (4.0); 7.3657 (6.0); 7.2630 (20.7); 5.5406 (2.8); 5.5198 (4.6); 5.4985 (2.8); 3.7775 (0.8); 3.7613 (2.0); 3.7452 (0.9); 2.1366 (0.8); 2.1100 (0.5); 2.0924 (1.4); 2.0754 (2.3); 2.0576 (2.4); 2.0402 (1.6); 2.0228 (0.7); 1.8779 (0.8); 1.8693 (1.0); 1.8615 (2.2); 1.8532 (1.0); 1.8453 (0.9); 1.2401 (0.7); 0.9286 (16.0); 0.9119 (15.9); 0.6517 (15.2); 0.6349 (15.1); -0.0002 (22.6) I.1-319: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6773 (7.2); 8.6712 (8.4); 8.6179 (8.2); 8.6119 (6.8); 8.4003 (7.0); 8.2611 (3.6); 8.2416 (4.0); 8.0185 (3.2); 7.9992 (3.7); 7.7456 (4.9); 7.7419 (7.6); 7.7380 (4.6); 7.7113 (3.4); 7.6918 (6.1); 7.6725 (3.0); 7.5957 (5.4); 7.4295 (2.9); 7.4085 (3.2); 7.3642 (5.2); 7.2624 (56.8); 5.6189 (1.1); 5.5999 (2.6); 5.5838 (2.6); 5.5639 (1.3); 3.7724 (2.3); 3.7561 (6.3); 3.7400 (2.9); 3.7110 (1.7); 2.1296 (5.3); 1.9046 (0.6); 1.8886 (1.1); 1.8750 (3.2); 1.8684 (4.4); 1.8589 (8.4); 1.8512 (5.5); 1.8421 (4.6); 1.8217 (3.6); 1.8033 (2.7); 1.7865 (1.7); 1.7682 (1.1); 1.2559 (0.6); 1.2423 (0.8); 1.2221 (0.6); 0.8101 (7.1); 0.7917 (16.0); 0.7732 (7.6); -0.0002 (61.4) I.1-320: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6705 (12.9); 8.6646 (15.3); 8.6162 (15.2); 8.6101 (12.5); 8.4500 (11.9); 8.4001 (1.4); 8.2510 (6.3); 8.2313 (6.9); 8.0576 (5.7); 8.0385 (6.4); 8.0122 (1.0); 7.9934 (1.0); 7.7485 (13.2); 7.6953 (5.9); 7.6759 (10.6); 7.6566 (5.2); 7.5971 (10.1); 7.5206 (1.0); 7.4748 (5.2); 7.4554 (5.4); 7.3669 (10.6); 7.2621 (153.0); 6.9984 (0.8); 5.1164 (4.4); 5.0956 (8.1); 5.0749 (4.7); 3.9546 (0.7); 3.7708 (5.5); 3.7545 (13.5); 3.7385 (6.0); 2.1271 (15.4); 1.8743 (6.1); 1.8668 (7.6); 1.8581 (16.0); 1.8500 (7.8); 1.8421 (6.5); 1.4327 (3.6); 1.2546 (2.8); 1.2423 (4.4); 1.2332 (3.2); 1.2219 (4.2); 1.2094 (2.6); 1.2010 (1.9); 0.9584 (0.6); 0.9400 (1.2); 0.8057 (1.6); 0.7877 (3.1); 0.7690 (1.4); 0.5747 (1.0); 0.5532 (2.5); 0.5413 (3.5); 0.5270 (2.9); 0.5067 (1.6); 0.4407 (1.3); 0.4267 (2.4); 0.4147 (2.6); 0.4062 (3.5); 0.3940 (3.4); 0.3715 (2.6); 0.3573 (3.3); 0.3465 (3.9); 0.3344 (4.2); 0.3220 (3.1); 0.1459 (0.8); 0.0666 (1.3); 0.0552 (2.9); 0.0407 (3.6); 0.0308 (4.0); 0.0174 (3.3); -0.0002 (165.6); -0.1495 (0.9) BCS241005-Ausland STR 168 I.1-321: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6792 (7.0); 8.6746 (7.7); 8.6124 (7.7); 8.6068 (6.6); 8.2563 (9.8); 8.2363 (10.8); 7.7696 (10.5); 7.7496 (9.9); 7.6476 (4.8); 7.6264 (6.5); 7.6175 (9.8); 7.5539 (3.7); 7.5344 (3.8); 7.2640 (39.6); 7.1403 (6.6); 7.1198 (6.2); 5.7735 (0.7); 5.7553 (2.4); 5.7374 (3.6); 5.7200 (2.5); 5.7041 (0.8); 3.7725 (2.1); 3.7574 (4.9); 3.7414 (2.4); 2.1349 (1.6); 1.8760 (2.0); 1.8676 (2.9); 1.8593 (5.3); 1.8520 (3.0); 1.8443 (2.3); 1.4804 (15.5); 1.4638 (16.0); 1.4332 (2.0); 1.2560 (1.0); -0.0002 (43.1) I.1-322: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6381 (2.8); 8.6321 (3.3); 8.5871 (3.1); 8.5811 (2.5); 8.2461 (3.6); 8.2253 (4.0); 8.1765 (1.0); 8.1716 (1.0); 7.9500 (2.9); 7.9449 (2.9); 7.9276 (0.6); 7.9227 (0.6); 7.9067 (0.6); 7.9018 (0.6); 7.8235 (4.0); 7.8027 (3.6); 7.6932 (1.4); 7.6881 (1.3); 7.6724 (1.9); 7.6673 (1.7); 7.5754 (1.0); 7.5533 (3.6); 7.5323 (2.4); 7.2625 (18.2); 7.2277 (1.0); 7.2041 (1.0); 5.5539 (1.0); 5.5343 (1.4); 5.5118 (1.0); 3.9712 (16.0); 3.9484 (0.5); 1.9895 (0.5); 1.9724 (0.9); 1.9550 (0.9); 1.9371 (0.6); 1.2631 (2.2); 0.8986 (1.1); 0.8818 (3.3); 0.8734 (6.4); 0.8640 (2.3); 0.8567 (6.1); 0.5994 (5.7); 0.5825 (5.7); -0.0002 (22.0); -0.0084 (1.2) I.1-323: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6440 (1.6); 8.6380 (1.9); 8.5939 (1.8); 8.5880 (1.4); 8.2502 (2.1); 8.2296 (2.4); 7.8187 (2.3); 7.7981 (2.1); 7.5182 (1.9); 7.5131 (1.5); 7.4978 (0.6); 7.4931 (0.7); 7.2685 (2.1); 7.2619 (0.6); 7.2390 (0.6); 7.1373 (0.5); 7.1161 (0.6); 5.5626 (0.6); 5.5432 (0.8); 5.5208 (0.6); 3.9736 (8.9); 2.1758 (16.0); 1.9768 (0.5); 1.9594 (0.5); 0.8743 (3.5); 0.8575 (3.4); 0.6079 (3.3); 0.5911 (3.3); -0.0002 (2.3) I.1-324: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6190 (2.7); 8.6131 (3.5); 8.5897 (3.4); 8.5837 (2.3); 8.2438 (3.7); 8.2230 (4.1); 7.8236 (4.1); 7.8028 (3.7); 7.4974 (2.0); 7.4940 (3.1); 7.3439 (1.9); 7.3386 (2.3); 7.3350 (1.8); 7.2642 (7.1); 7.2041 (1.9); 7.1988 (2.5); 7.1943 (1.6); 7.1343 (1.0); 7.1112 (1.1); 5.5460 (1.0); 5.5263 (1.4); 5.5037 (1.0); 5.3017 (5.2); 3.9694 (15.7); 3.8531 (16.0); 2.1742 (0.6); 1.9808 (0.5); 1.9638 (0.9); 1.9460 (0.9); 1.9287 (0.6); 1.6147 (5.0); 1.2564 (0.5); 0.8730 (6.2); 0.8562 (6.0); 0.5941 (5.9); 0.5772 (5.8); -0.0002 (7.8) I.1-325: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6141 (2.8); 8.6081 (3.4); 8.5704 (3.2); 8.5644 (2.5); 8.2593 (3.6); 8.2550 (1.3); 8.2426 (1.7); 8.2385 (4.0); 7.8470 (4.0); 7.8426 (1.4); 7.8261 (3.5); 7.7325 (1.8); 7.7286 (2.8); 7.7246 (1.7); 7.5964 (1.9); 7.3912 (1.8); 7.2627 (14.2); 7.1130 (0.8); 7.0914 (0.9); 5.7327 (1.0); 5.7111 (1.9); 5.6894 (1.0); 5.3021 (7.8); 3.9798 (16.0); 2.5874 (0.8); 2.5672 (0.8); 1.8659 (0.7); 1.8588 (0.8); 1.8437 (1.1); 1.8223 (1.0); 1.8010 (0.5); 1.7166 (0.6); 1.7109 (0.6); 1.6888 (0.7); 1.6248 (0.6); 1.6149 (0.9); 1.6064 (1.1); 1.5969 (1.1); 1.5821 (10.2); 1.4166 (0.7); 1.3933 (0.8); -0.0002 (16.8); -0.0083 (0.9) BCS241005-Ausland STR 169 I.1-326: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6285 (2.8); 8.6226 (3.4); 8.5820 (3.3); 8.5761 (2.6); 8.2755 (6.1); 8.2714 (5.8); 8.2499 (4.3); 8.0339 (2.3); 7.8599 (4.2); 7.8391 (3.7); 7.2639 (6.6); 7.2420 (1.0); 7.2203 (1.0); 5.7822 (1.0); 5.7604 (2.0); 5.7386 (1.0); 5.3020 (7.4); 3.9841 (16.0); 2.6250 (0.9); 2.6046 (0.9); 1.9107 (0.6); 1.8997 (0.7); 1.8909 (0.8); 1.8817 (0.8); 1.8710 (0.6); 1.8609 (1.1); 1.8391 (1.0); 1.8176 (0.6); 1.8118 (0.5); 1.7301 (0.6); 1.7255 (0.7); 1.7029 (0.8); 1.6817 (0.5); 1.6337 (2.5); 1.6191 (1.4); 1.6097 (1.2); 1.5986 (1.3); 1.5906 (0.9); 1.5794 (0.6); 1.4218 (0.8); 1.3980 (0.8); 1.3718 (0.5); -0.0002 (7.9) I.1-327: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6048 (2.8); 8.5989 (3.4); 8.5583 (3.2); 8.5524 (2.5); 8.2555 (3.6); 8.2348 (4.2); 7.9356 (2.9); 7.9306 (2.9); 7.8546 (4.0); 7.8339 (3.8); 7.6802 (1.4); 7.6751 (1.3); 7.6594 (1.9); 7.6543 (1.8); 7.5514 (3.1); 7.5307 (2.3); 7.2630 (11.2); 7.0991 (0.9); 7.0776 (1.0); 5.7308 (1.0); 5.7092 (2.0); 5.6875 (1.0); 5.3020 (10.9); 3.9779 (16.0); 2.5803 (0.8); 2.5597 (0.9); 1.8579 (0.7); 1.8411 (1.4); 1.8203 (1.3); 1.7995 (0.6); 1.7047 (0.6); 1.6823 (0.8); 1.6288 (0.5); 1.6206 (0.7); 1.6087 (1.0); 1.5895 (7.9); 1.5808 (1.6); 1.4171 (0.8); 1.3936 (0.8); 1.3666 (0.5); -0.0002 (13.2); -0.0083 (0.8) I.1-328: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6130 (2.7); 8.6070 (3.4); 8.5656 (3.2); 8.5597 (2.5); 8.2594 (3.6); 8.2386 (4.0); 7.8481 (4.0); 7.8274 (3.6); 7.5010 (3.3); 7.4959 (2.6); 7.4806 (1.1); 7.4757 (1.2); 7.2634 (8.4); 7.1294 (1.3); 7.1143 (1.3); 7.1079 (1.3); 5.7363 (1.0); 5.7148 (2.0); 5.6932 (1.0); 5.3020 (10.5); 3.9798 (16.0); 2.5830 (0.8); 2.5629 (0.8); 1.8731 (0.5); 1.8638 (0.8); 1.8530 (0.8); 1.8437 (1.4); 1.8325 (0.6); 1.8229 (1.3); 1.8018 (0.5); 1.7092 (0.6); 1.6866 (0.8); 1.6335 (0.5); 1.6253 (0.6); 1.6046 (6.5); 1.5851 (1.2); 1.5782 (1.0); 1.4195 (0.7); 1.3928 (0.8); 1.3692 (0.5); -0.0002 (10.0); -0.0082 (0.5) I.1-329: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6097 (2.3); 8.6038 (2.9); 8.5696 (2.8); 8.5637 (2.1); 8.2563 (3.2); 8.2356 (3.6); 7.8442 (3.6); 7.8235 (3.2); 7.6990 (5.4); 7.6943 (5.3); 7.5144 (1.6); 7.5099 (2.6); 7.5053 (1.3); 7.2622 (19.9); 7.0821 (0.8); 7.0617 (0.8); 5.7213 (0.9); 5.7000 (1.7); 5.6781 (0.9); 5.3021 (4.7); 3.9791 (13.7); 2.5845 (0.8); 2.5640 (0.8); 1.8633 (0.8); 1.8539 (0.8); 1.8418 (1.2); 1.8204 (1.0); 1.7088 (0.6); 1.6867 (0.7); 1.6229 (0.6); 1.6132 (0.8); 1.6043 (1.1); 1.5953 (1.1); 1.5832 (1.1); 1.5660 (16.0); 1.4156 (0.7); 1.3920 (0.8); 1.2611 (0.5); 0.8817 (0.5); -0.0002 (23.7); -0.0082 (1.3) BCS241005-Ausland STR 170 I.1-330: 1H-NMR(400.6 MHz, CDCl3): δ= 8.5972 (2.7); 8.5914 (3.4); 8.5633 (3.4); 8.5574 (2.4); 8.2542 (3.7); 8.2334 (4.2); 7.8638 (4.1); 7.8431 (3.7); 7.4849 (3.1); 7.3302 (2.3); 7.2625 (17.1); 7.2024 (2.0); 7.1974 (2.5); 7.1927 (1.6); 7.0657 (1.0); 7.0442 (1.1); 5.7209 (1.0); 5.6992 (2.0); 5.6776 (1.0); 5.3020 (6.3); 3.9759 (15.6); 3.8511 (16.0); 2.5807 (0.9); 2.5601 (0.9); 1.8666 (1.0); 1.8570 (0.9); 1.8462 (1.5); 1.8368 (0.8); 1.8251 (1.3); 1.8037 (0.6); 1.7045 (0.7); 1.6815 (0.9); 1.6596 (0.6); 1.6177 (0.8); 1.6099 (1.1); 1.5996 (1.3); 1.5909 (1.5); 1.5726 (14.3); 1.4162 (0.8); 1.3930 (0.9); 1.3661 (0.6); -0.0002 (20.3) I.1-331: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6418 (1.7); 8.6358 (2.0); 8.5985 (2.0); 8.5927 (1.5); 8.2338 (2.3); 8.2133 (2.5); 7.7619 (2.6); 7.7413 (2.3); 7.6024 (1.9); 7.4026 (1.4); 7.2617 (26.1); 7.2210 (1.6); 5.6858 (0.6); 5.6682 (0.8); 5.6499 (0.6); 3.9726 (9.4); 1.5556 (16.0); 1.4296 (8.9); 1.4232 (4.9); 1.4062 (4.1); 0.9236 (0.7); 0.9075 (2.4); 0.8974 (1.1); 0.8346 (1.3); 0.8249 (2.5); 0.8084 (0.8); -0.0002 (28.1) I.1-332: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6423 (2.8); 8.6363 (3.4); 8.5999 (3.3); 8.5939 (2.5); 8.2344 (3.8); 8.2137 (4.2); 7.7629 (4.2); 7.7422 (3.8); 7.5967 (2.9); 7.4380 (2.2); 7.2620 (24.7); 7.2105 (2.2); 5.6908 (0.9); 5.6725 (1.2); 5.6543 (0.9); 3.9728 (16.0); 3.0037 (0.9); 2.9862 (1.2); 2.9690 (1.0); 1.5648 (11.0); 1.4253 (6.6); 1.4086 (6.4); 1.2860 (15.6); 1.2688 (15.2); -0.0002 (26.2); -0.0080 (1.3) I.1-333: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6376 (6.2); 8.6336 (7.2); 8.5773 (6.4); 8.5733 (5.8); 8.2246 (7.8); 8.2106 (8.8); 7.7418 (8.1); 7.7278 (8.1); 7.5923 (2.8); 7.5895 (3.5); 7.5785 (2.7); 7.5757 (4.0); 7.5649 (6.6); 7.5624 (5.2); 7.2903 (1.7); 7.2804 (1.3); 7.2771 (1.6); 7.2603 (33.7); 7.2414 (0.3); 7.1170 (5.5); 7.1033 (5.3); 5.6823 (0.5); 5.6710 (1.8); 5.6586 (2.3); 5.6469 (1.9); 5.6356 (0.5); 3.9714 (37.1); 3.9525 (0.3); 2.0432 (0.4); 1.5635 (50.0); 1.5450 (0.4); 1.4001 (13.7); 1.3890 (13.9); 1.2845 (0.3); 1.2583 (0.7); 0.8819 (0.4); 0.0755 (1.0); 0.0697 (22.6); 0.0635 (1.1); 0.0053 (1.4); -0.0001 (38.6); -0.0056 (1.8); -0.0191 (0.3) I.1-334: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1499 (1.6); 9.4968 (4.0); 9.4771 (4.3); 8.7517 (9.0); 8.7457 (10.8); 8.7003 (11.7); 8.6943 (10.0); 8.5632 (15.7); 8.3197 (7.0); 8.0991 (10.8); 8.0782 (14.2); 7.9404 (13.3); 7.9196 (10.6); 5.1678 (2.6); 5.1475 (3.8); 5.1443 (3.7); 5.1240 (2.9); 3.3456 (7.7); 2.6788 (0.5); 2.5325 (1.8); 2.5188 (36.6); 2.5146 (71.2); 2.5102 (92.8); 2.5057 (69.7); 2.5015 (37.9); 2.3371 (0.5); 2.2739 (1.2); 2.2571 (1.9); 2.2500 (1.7); 2.2404 (1.8); 2.2334 (2.0); 2.2165 (1.4); 2.2000 (0.6); 1.2740 (0.6); 1.2597 (0.6); 1.2283 (2.5); 1.1841 (2.2); 1.1723 (1.8); 1.1459 (0.7); 0.9442 (15.7); 0.9278 (16.0); 0.7773 (0.6); 0.5129 (14.2); 0.4961 (14.6); -0.0002 (14.3); -0.0084 (1.3) BCS241005-Ausland STR 171 I.1-335: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7242 (0.8); 8.7182 (1.0); 8.6759 (1.1); 8.6699 (0.9); 8.1730 (0.9); 8.1680 (0.9); 8.0900 (1.0); 8.0693 (1.3); 7.9451 (1.2); 7.9244 (1.0); 7.8622 (0.6); 7.8570 (0.5); 7.7547 (1.0); 7.7338 (0.7); 3.3333 (16.0); 2.5110 (25.1); 2.5070 (47.2); 2.5026 (60.2); 2.4982 (42.8); 2.4940 (20.8); 2.0865 (2.9); 1.2343 (0.8); 1.1805 (1.4); 1.1689 (1.4); 1.1395 (1.0); 0.9126 (1.5); 0.8962 (1.5); 0.4714 (1.4); 0.4545 (1.3); -0.0002 (8.4) I.1-337: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3540 (0.7); 9.3360 (0.7); 8.7042 (1.3); 8.6984 (1.7); 8.6704 (1.8); 8.6644 (1.3); 8.4895 (2.7); 8.3101 (1.2); 8.0689 (1.7); 8.0485 (2.3); 7.9389 (2.2); 7.9185 (1.7); 5.4611 (0.6); 5.4552 (0.5); 3.3353 (16.0); 2.5076 (43.5); 2.5036 (54.9); 2.4995 (40.2); 2.0873 (4.1); 1.9103 (2.6); 1.7152 (0.6); 1.3551 (0.7); 1.2329 (1.2); -0.0002 (7.3) I.1-338: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1442 (0.7); 9.0108 (2.2); 8.9929 (2.4); 8.6845 (4.2); 8.6786 (5.5); 8.6517 (5.9); 8.6457 (4.3); 8.1160 (5.0); 8.1111 (4.8); 8.0914 (5.4); 8.0708 (7.5); 7.9707 (7.2); 7.9502 (5.2); 7.8458 (2.1); 7.8408 (1.9); 7.8248 (3.1); 7.8198 (2.9); 7.7445 (5.4); 7.7235 (3.7); 5.3945 (1.4); 5.3763 (1.7); 5.3697 (1.7); 5.3514 (1.5); 3.3375 (14.8); 2.8080 (0.5); 2.7890 (0.9); 2.7665 (1.0); 2.7464 (0.6); 2.6734 (0.6); 2.5087 (70.4); 2.5044 (88.7); 2.5001 (63.6); 2.3313 (0.7); 2.0876 (16.0); 2.0049 (1.0); 1.9909 (2.6); 1.9112 (0.8); 1.7165 (0.7); 1.6955 (1.4); 1.6740 (1.9); 1.6308 (0.7); 1.5666 (1.1); 1.5600 (1.2); 1.5397 (1.7); 1.5296 (1.6); 1.2598 (1.0); 1.2388 (1.4); 1.1931 (0.8); 1.1816 (0.8); 1.1753 (1.3); 1.1695 (0.8); 1.1575 (0.6); - 0.0002 (12.2); -0.0084 (0.7) I.1-346: 1H-NMR (400 MHz, CDCl3): δ= 8.6536 (2.9); 8.6476 (3.5); 8.6095 (3.4); 8.6035 (2.6); 8.3868 (2.3); 8.3673 (2.4); 8.2662 (5.4); 8.2341 (4.0); 8.2133 (4.3); 7.7507 (4.2); 7.7299 (3.8); 7.4613 (2.5); 7.4392 (2.5); 7.2654 (6.0); 7.2461 (1.4); 7.2264 (1.4); 6.3869 (4.7); 5.6777 (0.9); 5.6602 (1.2); 5.6417 (0.9); 3.9720 (16.0); 3.5734 (8.0); 3.2864 (0.5); 2.1737 (5.6); 1.4368 (5.9); 1.4200 (5.8); 1.2561 (1.4); -0.0002 (7.1) I.1-347: 1H-NMR (400 MHz, CDCl3): δ= 8.6108 (0.7); 8.5963 (0.7); 8.5641 (0.5); 8.5582 (0.6); 8.5100 (0.6); 8.2042 (0.8); 8.1842 (1.5); 8.1645 (0.8); 7.7189 (0.9); 7.6979 (1.6); 7.6870 (0.7); 7.6769 (0.9); 7.6668 (0.9); 7.3837 (0.5); 7.3616 (0.9); 7.2658 (2.7); 3.9571 (3.7); 3.9539 (3.5); 3.9433 (0.7); 3.7886 (0.8); 3.7711 (9.1); 2.1740 (16.0); 1.7215 (2.3); 1.6478 (2.6); 1.6249 (0.7); 1.3558 (1.2); 1.3390 (1.2); 1.3241 (1.3); 1.3074 (1.3); 1.2558 (0.5); - 0.0002 (3.2) BCS241005-Ausland STR 172 I.1-348: 1H-NMR (400 MHz, CDCl3): δ= 8.6591 (1.4); 8.6531 (1.7); 8.6124 (1.6); 8.6064 (1.3); 8.4467 (1.2); 8.4271 (1.2); 8.2749 (2.8); 8.2353 (1.9); 8.2146 (2.1); 7.7485 (2.0); 7.7277 (1.9); 7.4720 (1.2); 7.4498 (1.3); 7.2629 (7.5); 7.2366 (0.7); 7.2166 (0.7); 5.6651 (0.6); 3.9735 (7.7); 3.7880 (16.0); 2.1744 (4.8); 1.6064 (1.0); 1.4394 (2.9); 1.4227 (2.9); 1.2566 (0.6); -0.0002 (9.0) I.1-349: 1H-NMR (400 MHz, CDCl3): δ= 8.6016 (2.2); 8.5961 (4.9); 8.5917 (3.0); 8.5856 (1.0); 8.5766 (2.3); 8.5706 (1.4); 8.2001 (2.5); 8.1935 (2.7); 8.1886 (0.9); 8.1836 (0.9); 8.1787 (2.9); 8.1720 (2.9); 7.6952 (2.7); 7.6904 (0.9); 7.6830 (0.5); 7.6788 (3.5); 7.6739 (3.2); 7.6696 (0.5); 7.6623 (0.8); 7.6574 (2.5); 7.2626 (15.2); 5.4342 (0.7); 5.4169 (1.0); 5.3997 (0.7); 5.3004 (16.0); 4.9722 (0.7); 4.9578 (0.8); 4.9431 (0.7); 4.9287 (0.7); 4.8954 (0.7); 4.8805 (0.8); 4.8673 (0.7); 4.8524 (0.7); 3.9621 (13.8); 3.9585 (13.2); 3.2737 (0.6); 3.2709 (0.6); 3.2460 (1.0); 3.2434 (1.0); 3.2325 (0.6); 3.2305 (0.6); 3.2175 (1.1); 3.2152 (1.0); 3.1530 (0.6); 3.1510 (0.6); 3.1386 (0.6); 3.1365 (0.6); 2.0204 (5.8); 1.9778 (6.1); 1.6035 (1.4); 1.3494 (4.3); 1.3381 (4.3); 1.3327 (4.6); 1.3213 (4.1); 0.0079 (0.6); -0.0002 (22.1); -0.0085 (0.7) I.1-351: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6931 (0.5); 8.6453 (0.6); 8.6389 (5.8); 8.6316 (0.5); 8.3818 (0.7); 8.3644 (0.8); 8.0575 (0.5); 7.9820 (2.2); 7.9772 (0.7); 7.9655 (0.8); 7.9607 (2.6); 7.6434 (2.5); 7.6385 (0.8); 7.6268 (0.7); 7.6220 (2.2); 7.3241 (1.4); 7.3186 (9.1); 7.3120 (1.8); 7.3064 (0.5); 5.0216 (0.8); 5.0045 (0.5); 3.8991 (2.6); 3.8950 (9.7); 3.6968 (0.6); 3.6508 (0.8); 3.3195 (16.0); 3.3027 (0.7); 3.3001 (0.7); 3.2585 (0.6); 3.2559 (0.6); 2.5407 (0.6); 2.5240 (0.7); 2.5193 (1.0); 2.5105 (15.1); 2.5060 (33.3); 2.5014 (46.8); 2.4968 (32.5); 2.4922 (14.4); 1.9887 (1.5); 1.9314 (5.6); 1.8874 (1.1); 1.3466 (2.9); 1.3298 (2.9); 1.2491 (1.1); 1.2326 (0.8); 1.1745 (0.9); 0.8581 (1.1); 0.0080 (0.9); -0.0002 (35.2); -0.0085 (1.0) I.1-352: 1H-NMR (400.6 MHz, d6-DMSO): δ= 8.7040 (0.7); 8.6918 (0.8); 8.6441 (1.7); 8.6379 (5.6); 8.6335 (4.5); 8.6273 (1.4); 8.3639 (1.0); 8.3463 (1.0); 8.0566 (0.6); 8.0354 (0.7); 7.9835 (3.2); 7.9788 (1.0); 7.9670 (1.1); 7.9622 (3.7); 7.6994 (0.7); 7.6782 (0.6); 7.6232 (3.5); 7.6184 (1.0); 7.6067 (1.0); 7.6020 (3.1); 7.4090 (0.6); 7.4054 (0.5); 7.3586 (0.6); 7.3345 (1.2); 7.3275 (2.2); 7.3200 (10.2); 7.3147 (2.1); 7.3115 (1.1); 7.3091 (1.4); 7.3052 (0.7); 5.0500 (0.7); 5.0329 (1.0); 5.0157 (0.7); 4.0378 (1.1); 4.0201 (1.1); 3.7008 (0.9); 3.6548 (1.1); 3.3197 (16.0); 3.3117 (1.6); 3.2672 (0.8); 3.2645 (0.8); 2.6701 (0.6); 2.5407 (1.4); 2.5239 (1.3); 2.5192 (1.9); 2.5105 (30.5); 2.5059 (67.0); 2.5013 (94.3); 2.4967 (64.8); 2.4922 (28.4); 2.3284 (0.6); 1.9886 (5.2); 1.9350 (7.9); 1.9087 (1.3); 1.8916 (1.5); 1.3553 (1.4); 1.3454 (4.0); 1.3285 (4.0); 1.2498 (0.8); 1.2330 (1.0); 1.1922 (1.5); 1.1809 (0.6); 1.1744 (3.1); 1.1566 (1.5); 0.0080 (1.9); -0.0002 (70.8); -0.0085 (2.0) BCS241005-Ausland STR 173 I.1-353: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7119 (0.6); 8.7061 (0.8); 8.6755 (0.8); 8.6694 (0.6); 8.6491 (0.5); 8.3359 (0.5); 8.3317 (0.5); 8.2528 (0.6); 8.0901 (0.8); 8.0696 (1.0); 7.8424 (0.9); 7.8298 (0.9); 7.8257 (1.0); 6.6179 (0.6); 5.7615 (2.1); 3.8818 (3.1); 3.3327 (16.0); 2.8424 (2.0); 2.8378 (1.8); 2.5066 (42.0); 2.5022 (52.7); 2.4979 (37.8); 1.5162 (1.1); 1.4990 (1.1); -0.0002 (12.2); -0.0083 (0.7) I.1-354: 1H-NMR(400.6 MHz, d6-DMSO): δ= 7.8269 (0.6); 3.3310 (16.0); 2.8450 (0.9); 2.8402 (0.8); 2.6707 (0.6); 2.5102 (39.2); 2.5062 (73.9); 2.5018 (94.4); 2.4974 (67.4); 2.4931 (33.1); 2.3291 (0.7); 1.4936 (0.5); -0.0002 (43.8); -0.0085 (2.4) I.1-355: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0665 (1.6); 9.0483 (1.6); 8.6892 (3.0); 8.6832 (4.1); 8.6583 (4.4); 8.6523 (3.1); 8.0830 (3.8); 8.0623 (5.3); 7.9526 (5.0); 7.9320 (3.7); 7.8068 (1.2); 7.7843 (1.3); 7.6979 (2.4); 7.6292 (1.2); 7.6074 (1.2); 5.4138 (1.0); 5.3956 (1.2); 5.3890 (1.2); 5.3706 (1.0); 3.3364 (16.0); 2.8043 (0.6); 2.7821 (0.7); 2.6729 (0.6); 2.5082 (73.6); 2.5039 (93.9); 2.4995 (67.5); 2.3355 (0.6); 2.3309 (0.8); 2.1189 (0.7); 2.0873 (12.7); 2.0108 (0.7); 1.9104 (3.6); 1.7230 (0.6); 1.7004 (1.1); 1.6821 (1.4); 1.6409 (0.5); 1.5787 (0.8); 1.5603 (1.1); 1.5380 (1.1); 1.5187 (0.8); 1.3555 (1.4); 1.2986 (0.6); 1.2706 (0.8); 1.2581 (1.1); 1.2338 (1.5); 1.1813 (1.1); 1.1695 (1.6); 1.1406 (1.6); 1.0267 (0.5); 1.0109 (0.5); 0.8550 (0.6); -0.0002 (13.1); -0.0081 (0.7) I.1-356: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1104 (0.6); 9.0923 (0.6); 8.6913 (1.1); 8.6853 (1.4); 8.6587 (1.5); 8.6527 (1.1); 8.0815 (1.3); 8.0607 (1.9); 8.0156 (0.8); 8.0117 (1.3); 8.0078 (0.8); 7.9468 (1.8); 7.9261 (1.3); 7.7734 (1.5); 3.3342 (16.0); 2.5074 (42.1); 2.5030 (53.9); 2.4986 (38.7); 2.4944 (19.2); 2.0869 (3.4); 1.9098 (0.7); -0.0002 (8.7) I.1-357: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6413 (2.7); 8.6353 (3.3); 8.5952 (3.2); 8.5892 (2.4); 8.2318 (3.7); 8.2111 (4.0); 7.7997 (1.6); 7.7954 (2.6); 7.7908 (1.6); 7.7521 (4.0); 7.7314 (3.6); 7.6974 (1.4); 7.6781 (1.6); 7.4943 (0.9); 7.4769 (1.3); 7.4743 (1.3); 7.4048 (1.6); 7.3853 (2.4); 7.3656 (1.0); 7.3304 (0.8); 7.3109 (0.8); 7.2629 (11.2); 5.6868 (0.9); 5.6696 (1.1); 5.6506 (0.9); 3.9730 (16.0); 1.5870 (9.9); 1.4140 (6.3); 1.3972 (6.3); -0.0002 (12.0); -0.0084 (0.7) I.1-358: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6370 (2.7); 8.6310 (3.2); 8.5838 (3.1); 8.5778 (2.5); 8.2289 (3.6); 8.2080 (4.0); 7.7690 (3.7); 7.7644 (1.4); 7.7527 (5.6); 7.7479 (5.6); 7.7321 (3.8); 7.4290 (4.2); 7.4243 (1.4); 7.4077 (3.8); 7.3248 (0.8); 7.3053 (0.8); 7.2623 (18.7); 5.6898 (0.9); 5.6724 (1.1); 5.6536 (0.9); 3.9717 (16.0); 1.5727 (15.4); 1.4083 (6.2); 1.3916 (6.3); -0.0002 (20.0); -0.0083 (1.1) I.1-359: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6413 (1.8); 8.6354 (2.1); 8.5957 (2.1); 8.5898 (1.6); 8.2315 (2.5); 8.2110 (2.7); 7.9479 (1.9); 7.7510 (2.9); 7.7303 (2.9); 7.6482 (0.9); 7.6270 (1.0); 7.3436 (1.1); BCS241005-Ausland STR 174 7.3239 (1.9); 7.3041 (1.3); 7.2926 (0.9); 7.2622 (16.2); 5.6828 (0.6); 5.6641 (0.8); 5.6470 (0.6); 3.9730 (10.1); 1.5651 (16.0); 1.4135 (4.4); 1.3968 (4.4); 1.2613 (0.6); 0.8818 (0.6); -0.0002 (17.5) I.1-360: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6365 (2.8); 8.6305 (3.2); 8.5822 (3.2); 8.5763 (2.6); 8.2281 (3.8); 8.2073 (4.2); 7.7518 (4.2); 7.7310 (3.9); 7.6982 (3.4); 7.6769 (5.0); 7.5902 (4.9); 7.5689 (3.4); 7.3294 (1.0); 7.3104 (1.0); 7.2630 (9.3); 5.6862 (1.0); 5.6682 (1.2); 5.6501 (0.9); 3.9712 (16.0); 1.5944 (8.2); 1.4067 (6.6); 1.3900 (6.5); -0.0002 (10.1); -0.0084 (0.6) I.1-361: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6590 (0.5); 8.0426 (0.6); 7.7981 (0.5); 3.3320 (16.0); 2.5064 (39.0); 2.5020 (50.1); 2.4976 (36.1); 2.4934 (18.0); 1.4761 (0.6); 1.4587 (0.6); 1.3963 (1.7); 0.8241 (0.5); -0.0002 (9.6); -0.0084 (0.6) I.1-362: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1119 (0.5); 9.0576 (1.0); 9.0412 (1.0); 8.6833 (1.9); 8.6772 (2.8); 8.6601 (3.2); 8.6540 (2.1); 8.0683 (2.7); 8.0472 (3.2); 7.8051 (3.0); 7.7841 (2.6); 7.7318 (2.0); 7.5727 (1.4); 7.3741 (1.4); 5.3412 (0.6); 5.3242 (0.9); 5.3071 (0.6); 3.3345 (16.0); 2.9961 (0.6); 2.9789 (0.8); 2.9615 (0.6); 2.5256 (1.2); 2.5120 (29.8); 2.5077 (58.0); 2.5032 (75.5); 2.4987 (55.8); 2.4943 (29.8); 1.9901 (0.8); 1.4795 (3.3); 1.4623 (3.5); 1.3553 (0.6); 1.2410 (0.9); 1.2378 (1.0); 1.2254 (7.1); 1.2227 (6.8); 1.2083 (7.0); 1.2054 (6.4); 1.1747 (0.7); 1.1693 (0.5); 0.0078 (0.9); -0.0002 (16.8); - 0.0085 (1.2) I.1-363: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1553 (4.6); 9.1390 (4.8); 8.6873 (7.6); 8.6814 (11.0); 8.6636 (11.7); 8.6576 (7.6); 8.0648 (11.2); 8.0442 (13.1); 7.9614 (9.2); 7.8215 (4.8); 7.8171 (4.3); 7.7975 (5.1); 7.7931 (4.7); 7.7756 (12.9); 7.7551 (11.3); 5.3324 (0.7); 5.3157 (2.8); 5.2990 (4.3); 5.2822 (2.9); 5.2647 (0.8); 3.3417 (2.6); 2.6747 (0.6); 2.5098 (86.7); 2.5058 (107.0); 2.5017 (78.9); 2.3331 (0.9); 1.4775 (15.8); 1.4603 (16.0); 1.3564 (0.9); 1.1699 (0.6); -0.0002 (15.3) I.1-364: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1537 (2.2); 9.0639 (1.9); 9.0468 (1.9); 8.7306 (3.8); 8.7247 (4.6); 8.6952 (5.0); 8.6892 (3.6); 8.0991 (5.3); 8.0787 (6.0); 7.7826 (6.0); 7.7621 (5.2); 7.5670 (2.1); 7.5457 (2.8); 7.5432 (2.8); 7.4590 (2.2); 7.4411 (2.5); 7.4202 (1.6); 5.3038 (1.3); 5.2870 (2.0); 5.2699 (1.3); 3.3403 (16.0); 2.5086 (40.4); 2.5047 (49.5); 1.4384 (7.6); 1.4215 (7.5); 1.1699 (0.8); - 0.0002 (5.2) I.1-365: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6403 (2.8); 8.6344 (3.3); 8.5958 (3.4); 8.5898 (2.6); 8.2318 (3.9); 8.2113 (4.3); 7.7567 (4.2); 7.7360 (3.9); 7.4411 (3.1); 7.3867 (2.2); 7.2620 (19.0); 7.2492 (1.5); 7.0259 (2.2); 5.6789 (0.9); 5.6614 (1.3); 5.6431 (1.0); 3.9720 (16.0); 1.9826 (0.7); 1.9742 (0.8); 1.9618 (1.4); 1.9491 (0.8); 1.9408 (0.7); 1.5677 (7.6); 1.4164 (6.5); 1.3997 (6.5); 1.0811 (0.9); 1.0692 (2.3); BCS241005-Ausland STR 175 1.0647 (2.3); 1.0484 (2.3); 1.0438 (2.0); 1.0323 (0.9); 0.7810 (1.0); 0.7690 (3.0); 0.7649 (2.5); 0.7569 (2.6); 0.7525 (2.7); 0.7402 (0.8); -0.0002 (23.1); -0.0082 (1.3) I.1-366: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6523 (2.7); 8.6463 (3.1); 8.6012 (3.2); 8.5953 (2.5); 8.2323 (3.8); 8.2118 (4.1); 7.7368 (4.1); 7.7162 (3.8); 7.5756 (2.8); 7.4355 (1.3); 7.4138 (1.3); 7.3380 (1.0); 7.3192 (1.0); 7.2627 (13.8); 7.2510 (1.3); 7.2457 (1.6); 7.2306 (1.1); 7.2255 (1.4); 5.6645 (1.0); 5.6465 (1.3); 5.6288 (1.0); 3.9745 (15.3); 1.5788 (16.0); 1.4081 (6.6); 1.3914 (6.5); -0.0002 (14.5) I.1-367: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6467 (2.7); 8.6407 (3.2); 8.5941 (3.1); 8.5881 (2.5); 8.2314 (3.7); 8.2107 (4.0); 7.9006 (1.4); 7.8951 (1.4); 7.8833 (1.4); 7.8779 (1.4); 7.7437 (4.1); 7.7229 (4.4); 7.7178 (1.6); 7.7116 (1.1); 7.7070 (1.1); 7.7014 (1.0); 7.6959 (1.0); 7.6903 (0.9); 7.3011 (0.8); 7.2813 (0.9); 7.2627 (16.0); 7.2296 (1.5); 7.2082 (2.6); 7.1869 (1.3); 5.6708 (0.9); 5.6532 (1.1); 5.6348 (0.9); 3.9736 (16.0); 1.5797 (15.1); 1.4084 (6.4); 1.3918 (6.4); 1.2611 (0.6); 0.8818 (0.6); -0.0002 (16.8); - 0.0083 (1.0) I.1-368: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1084 (1.9); 9.0856 (3.0); 9.0693 (3.1); 8.6849 (5.2); 8.6792 (6.7); 8.6598 (7.2); 8.6540 (4.8); 8.0707 (7.2); 8.0502 (8.3); 7.7876 (8.3); 7.7672 (7.2); 7.7389 (6.2); 7.6247 (2.9); 7.6020 (4.6); 7.5740 (2.9); 5.3160 (1.9); 5.2990 (2.8); 5.2824 (1.9); 3.3258 (16.0); 2.5075 (68.3); 2.5038 (79.3); 2.3311 (0.7); 1.4692 (10.6); 1.4520 (10.6); 1.3566 (0.7); 1.1704 (0.6); - 0.0002 (27.0) I.1-369: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1051 (5.7); 9.0207 (4.4); 9.0045 (4.6); 8.6809 (6.9); 8.6756 (9.1); 8.6558 (9.8); 8.6515 (6.5); 8.0728 (10.6); 8.0531 (16.0); 8.0403 (5.1); 8.0367 (4.6); 7.8467 (2.3); 7.8419 (2.2); 7.8349 (2.5); 7.8279 (3.0); 7.8198 (2.8); 7.8134 (3.0); 7.8076 (3.1); 7.7973 (12.2); 7.7774 (10.6); 7.4978 (3.6); 7.4758 (6.6); 7.4535 (3.3); 5.3322 (0.6); 5.3155 (2.7); 5.2987 (4.2); 5.2821 (2.8); 5.2658 (0.8); 3.8226 (0.6); 3.3276 (8.7); 2.6741 (0.5); 2.5049 (81.5); 2.3331 (0.8); 1.4645 (15.6); 1.4474 (15.5); 1.3577 (1.6); 1.1890 (0.7); 1.1705 (1.0); 1.1507 (0.7); 0.0015 (28.0); -0.0002 (29.4) I.1-370: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6744 (7.2); 8.6685 (8.6); 8.6185 (8.6); 8.6125 (7.0); 8.2628 (10.0); 8.2423 (11.1); 7.7804 (10.8); 7.7600 (10.2); 7.5282 (3.3); 7.5085 (3.4); 7.4854 (8.2); 7.4637 (0.9); 7.4256 (5.9); 7.2609 (35.2); 7.0370 (5.7); 5.7632 (0.6); 5.7465 (2.4); 5.7289 (3.2); 5.7107 (2.4); 5.6930 (0.7); 3.7721 (0.7); 3.7563 (1.8); 3.7400 (0.8); 2.1322 (6.0); 2.0004 (0.8); 1.9877 (1.7); 1.9792 (2.0); 1.9670 (3.5); 1.9544 (2.2); 1.9460 (2.0); 1.9334 (1.1); 1.8747 (0.8); 1.8664 (0.9); 1.8585 (2.0); 1.8496 (1.0); 1.8425 (0.8); 1.4894 (15.6); 1.4727 (16.0); 1.4323 (2.3); 1.2577 (0.6); 1.2414 (1.2); 1.2229 (0.5); 1.0814 (2.1); 1.0692 (5.7); 1.0644 (6.0); 1.0483 (6.1); 1.0438 (5.6); 1.0323 (2.5); 0.7889 (2.3); 0.7770 (7.8); 0.7729 (6.6); 0.7648 (6.6); 0.7604 (7.8); 0.7481 (2.4); -0.0002 (42.9) BCS241005-Ausland STR 176 I.1-371: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.0995 (1.5); 9.0770 (1.6); 8.6932 (2.8); 8.6851 (4.4); 8.6612 (4.6); 8.6531 (3.0); 8.0648 (3.4); 8.0584 (3.5); 7.7966 (1.2); 7.7901 (1.1); 7.7685 (2.6); 7.7618 (5.6); 7.7353 (3.7); 7.7218 (4.6); 7.6938 (2.1); 7.4682 (3.3); 7.4649 (3.4); 7.2905 (2.0); 7.2863 (1.9); 7.2642 (1.8); 7.2600 (1.8); 5.4114 (0.9); 5.3888 (1.5); 5.3660 (1.0); 3.9453 (0.4); 3.8542 (15.8); 3.8181 (16.0); 3.3329 (19.2); 2.5092 (12.1); 2.5034 (16.2); 2.4976 (11.9); 1.4500 (5.5); 1.4272 (5.4); -0.0002 (3.8) I.1-372: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1291 (3.4); 9.0281 (4.4); 9.0119 (4.6); 8.6820 (7.8); 8.6760 (11.0); 8.6567 (11.6); 8.6508 (7.7); 8.0802 (10.8); 8.0598 (12.7); 7.8676 (5.8); 7.8635 (8.6); 7.8591 (5.6); 7.8085 (12.6); 7.7881 (11.0); 7.7605 (4.9); 7.7411 (5.4); 7.5892 (3.4); 7.5696 (4.5); 7.4754 (5.2); 7.4557 (7.9); 7.4360 (3.5); 5.3386 (0.6); 5.3216 (2.8); 5.3048 (4.3); 5.2878 (2.9); 5.2711 (0.8); 3.3416 (4.6); 2.5095 (65.4); 2.5053 (81.3); 2.5012 (59.4); 2.3321 (0.6); 1.4616 (16.0); 1.4444 (16.0); 1.3566 (1.8); 1.1822 (0.7); -0.0002 (38.1); -0.0078 (2.5) I.1-373: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1254 (8.8); 8.9738 (4.8); 8.9574 (4.9); 8.6697 (9.9); 8.6525 (10.4); 8.0783 (10.7); 8.0581 (12.2); 7.8443 (11.3); 7.8231 (13.8); 7.8123 (13.7); 7.7919 (10.9); 7.5067 (12.1); 7.4857 (10.6); 5.3191 (3.0); 5.3024 (4.3); 5.2853 (2.9); 3.3397 (6.8); 2.6741 (0.8); 2.5050 (96.4); 2.3312 (1.0); 1.4513 (16.0); 1.4344 (15.7); 1.1821 (0.9); -0.0002 (33.4) I.1-374: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1242 (4.6); 9.0343 (4.4); 9.0180 (4.5); 8.6810 (7.7); 8.6750 (11.0); 8.6555 (11.7); 8.6495 (7.8); 8.0791 (11.3); 8.0585 (13.2); 8.0104 (5.9); 8.0063 (8.8); 8.0021 (5.4); 7.8069 (13.2); 7.7958 (6.5); 7.7864 (12.0); 7.7765 (5.9); 7.7189 (3.9); 7.6991 (4.3); 7.4088 (4.6); 7.3891 (8.0); 7.3694 (3.9); 5.3330 (0.7); 5.3164 (2.7); 5.2995 (4.2); 5.2827 (2.8); 5.2659 (0.8); 3.6013 (0.6); 3.3371 (16.0); 2.6727 (0.8); 2.5082 (107.6); 2.5040 (134.6); 2.4997 (97.0); 2.3310 (1.0); 1.7592 (0.7); 1.4583 (15.6); 1.4411 (15.6); 1.3557 (0.8); -0.0002 (66.0); -0.0077 (3.9) I.1-375: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1049 (0.6); 8.9569 (0.6); 8.9408 (0.6); 8.6705 (1.1); 8.6645 (1.6); 8.6479 (1.6); 8.6418 (1.0); 8.0713 (1.6); 8.0510 (1.9); 7.8023 (1.9); 7.7821 (1.6); 7.7654 (1.5); 7.7441 (2.1); 7.6419 (2.1); 7.6206 (1.5); 5.2956 (0.6); 3.3172 (16.0); 2.6698 (0.9); 2.5046 (85.1); 2.5008 (107.0); 2.4969 (80.2); 2.3277 (1.0); 1.9881 (0.5); 1.4456 (2.3); 1.4285 (2.3); -0.0002 (41.8); - 0.0083 (2.8) I.1-376: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3012 (1.8); 9.2845 (1.8); 8.7136 (3.8); 8.6915 (3.9); 8.2309 (0.6); 8.1803 (3.8); 8.1397 (0.6); 8.1171 (0.8); 8.0877 (4.0); 8.0699 (4.3); 7.8360 (0.9); 7.8128 (2.3); 7.7868 (5.8); 7.7677 (4.0); 7.7267 (0.6); 7.7003 (2.7); 7.6793 (2.0); 6.1776 (0.6); 6.1605 (0.8); 6.1351 (1.3); 6.1188 (0.8); 6.0915 (0.7); 5.8836 (1.2); 5.8664 (1.9); 5.8488 (1.0); 5.2165 (2.1); 5.1911 (2.0); 4.9724 (2.1); 4.9296 (1.9); 3.9493 (1.5); 3.9000 (12.4); 3.3834 (3.2); 3.3333 (16.0); 2.6697 (0.8); BCS241005-Ausland STR 177 2.5514 (19.7); 2.5046 (120.0); 2.5012 (121.1); 2.3309 (0.7); 1.9935 (0.6); 0.0490 (3.5); 0.0022 (24.3); - 0.0002 (28.7); -0.0019 (28.5) I.1-377: 1H-NMR(600.3 MHz, MeOD): δ= 8.6951 (1.4); 8.6910 (1.6); 8.6342 (1.6); 8.6302 (1.5); 8.1999 (1.8); 8.1862 (2.0); 8.1085 (1.6); 8.1052 (1.7); 7.7840 (1.9); 7.7699 (2.1); 7.7656 (1.0); 7.7550 (0.9); 7.7516 (0.9); 7.6187 (1.7); 7.6048 (1.4); 6.1506 (0.3); 6.1392 (0.4); 6.1335 (0.4); 6.1221 (0.7); 6.1106 (0.4); 6.1050 (0.4); 6.0935 (0.4); 5.9896 (0.8); 5.9781 (0.7); 5.2573 (1.0); 5.2402 (0.9); 5.0222 (0.9); 4.9936 (0.9); 4.8459 (36.9); 4.8218 (0.4); 3.3320 (17.5); 3.3293 (34.5); 3.3266 (50.0); 3.3240 (37.7); 3.3214 (20.8); 3.3018 (0.3) I.1-378: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1411 (0.9); 9.1215 (1.0); 8.7300 (2.5); 8.7240 (3.1); 8.6797 (3.7); 8.6737 (3.1); 8.0929 (2.8); 8.0884 (0.9); 8.0764 (1.1); 8.0717 (3.8); 7.9327 (7.4); 7.9279 (10.0); 7.9225 (1.2); 7.9104 (1.0); 7.9059 (2.7); 7.8099 (1.8); 7.8051 (3.2); 7.8004 (1.5); 5.0980 (0.6); 5.0781 (0.8); 5.0744 (0.8); 5.0544 (0.7); 3.1741 (16.0); 2.5253 (0.5); 2.5165 (6.7); 2.5120 (14.4); 2.5074 (19.8); 2.5028 (13.5); 2.4983 (5.8); 2.4640 (1.0); 1.9144 (2.4); 1.2301 (0.7); 1.1836 (0.6); 1.1717 (1.0); 0.9151 (4.0); 0.8987 (3.9); 0.4838 (3.5); 0.4669 (3.4); -0.0002 (15.4) I.1-379: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0381 (2.2); 9.0200 (2.3); 8.6885 (5.4); 8.6824 (7.2); 8.6542 (8.2); 8.6481 (6.2); 8.0894 (6.0); 8.0851 (2.2); 8.0728 (2.5); 8.0683 (8.5); 7.9493 (7.8); 7.9448 (2.5); 7.9325 (2.2); 7.9283 (5.8); 7.8730 (14.1); 7.8682 (16.0); 7.8021 (4.0); 7.7973 (6.6); 7.7925 (3.1); 5.3992 (1.5); 5.3810 (1.6); 5.3743 (1.7); 5.3561 (1.5); 3.9121 (0.5); 3.5110 (2.2); 3.4131 (0.5); 3.2426 (0.6); 3.1730 (6.2); 2.8003 (0.8); 2.7790 (0.9); 2.7575 (0.5); 2.5287 (0.6); 2.5240 (0.9); 2.5153 (16.5); 2.5108 (35.5); 2.5062 (49.4); 2.5016 (34.6); 2.4971 (15.7); 2.0239 (0.7); 2.0161 (0.8); 2.0081 (0.8); 1.9960 (0.9); 1.9131 (2.8); 1.7249 (0.7); 1.7031 (1.2); 1.6979 (1.1); 1.6806 (1.6); 1.6593 (0.9); 1.6396 (0.6); 1.5941 (0.6); 1.5848 (0.8); 1.5771 (1.1); 1.5675 (0.9); 1.5587 (1.4); 1.5489 (1.1); 1.5393 (1.4); 1.5191 (0.8); 1.2995 (1.3); 1.2858 (0.9); 1.2588 (2.6); 1.2305 (2.0); 1.1890 (0.5); 1.1830 (0.7); 1.1711 (0.7); 0.8514 (0.6); 0.0080 (0.8); -0.0002 (30.8); -0.0085 (1.0) I.1-380: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9256 (1.1); 8.9073 (1.1); 8.6825 (2.2); 8.6766 (2.7); 8.6473 (2.9); 8.6413 (2.1); 8.0943 (2.6); 8.0737 (3.7); 7.9826 (3.5); 7.9620 (2.5); 7.6530 (2.4); 7.3785 (1.8); 7.3156 (1.6); 7.3108 (2.1); 7.3058 (1.2); 5.3897 (0.7); 5.3714 (0.8); 5.3644 (0.8); 5.3464 (0.7); 3.8138 (12.1); 3.3352 (16.0); 2.5074 (59.5); 2.5031 (74.4); 2.4988 (53.4); 2.3303 (0.6); 2.0868 (14.5); 2.0172 (0.6); 1.9099 (8.4); 1.6780 (0.9); 1.6641 (1.1); 1.6472 (0.7); 1.5308 (0.9); 1.5226 (0.9); 1.2252 (0.7); 1.1810 (0.6); 1.1691 (0.6); 1.1399 (0.6); -0.0002 (9.5) I.1-381: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0277 (0.9); 9.0081 (1.0); 8.7243 (1.9); 8.7184 (2.2); 8.6735 (2.4); 8.6676 (2.0); 8.0941 (2.2); 8.0734 (3.1); 7.9626 (2.9); 7.9421 (2.2); 7.7027 (2.1); 7.4283 BCS241005-Ausland STR 178 (1.3); 7.4244 (1.6); 7.3238 (1.3); 7.3192 (1.8); 7.3141 (1.1); 5.0806 (0.6); 5.0604 (0.8); 5.0370 (0.6); 3.8220 (10.5); 3.3345 (16.0); 2.5251 (1.6); 2.5073 (58.3); 2.5030 (74.4); 2.4987 (55.4); 2.0868 (3.2); 1.2339 (0.7); 1.1809 (1.1); 1.1692 (1.2); 0.9120 (3.5); 0.8957 (3.5); 0.4603 (3.1); 0.4435 (3.2); -0.0002 (9.8); -0.0084 (0.9) I.1-382: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6592 (1.6); 8.6532 (2.0); 8.6191 (1.8); 8.6132 (1.4); 8.0560 (1.6); 8.0260 (0.9); 8.0059 (0.9); 7.8540 (1.7); 7.6072 (1.3); 7.5271 (1.3); 7.3802 (0.7); 7.2605 (32.0); 3.9644 (9.4); 2.1878 (7.1); 1.5481 (16.0); 1.3321 (1.4); 1.3193 (1.4); 1.2625 (0.5); -0.0002 (30.8); -0.0082 (1.8) I.1-383: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6537 (1.6); 8.6476 (1.9); 8.6022 (1.7); 8.5961 (1.3); 8.0543 (1.5); 8.0254 (0.8); 8.0059 (0.8); 7.8028 (1.2); 7.6809 (0.7); 7.6763 (0.6); 7.6602 (1.0); 7.6554 (0.9); 7.5649 (1.8); 7.5441 (1.2); 7.3909 (0.6); 7.2606 (19.0); 3.9636 (9.6); 2.1888 (6.7); 1.5543 (16.0); 1.3319 (1.2); 1.3162 (1.2); -0.0002 (18.0); -0.0083 (0.9) I.1-384: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6446 (2.4); 8.6385 (3.3); 8.6136 (2.9); 8.6076 (2.0); 8.0522 (2.5); 8.0236 (1.3); 8.0040 (1.4); 7.5306 (2.4); 7.4482 (1.9); 7.3379 (0.8); 7.3190 (0.7); 7.2611 (17.8); 7.1709 (1.9); 3.9620 (16.0); 2.4344 (11.0); 2.1925 (11.2); 1.5636 (8.0); 1.3382 (2.0); 1.3225 (2.1); 1.2645 (0.7); 0.8819 (0.7); -0.0002 (16.8); -0.0084 (0.9) I.1-385: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6594 (1.6); 8.6533 (2.0); 8.6184 (1.8); 8.6123 (1.3); 8.0559 (1.4); 8.0264 (0.8); 8.0066 (0.8); 7.7121 (1.1); 7.7083 (1.6); 7.7044 (1.0); 7.5653 (1.1); 7.3757 (1.6); 7.2608 (16.4); 3.9646 (9.8); 2.1880 (6.7); 1.5555 (16.0); 1.3323 (1.2); 1.3194 (1.2); 0.8820 (0.5); -0.0002 (15.6); -0.0082 (0.8) I.1-386: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6955 (1.1); 8.6894 (1.4); 8.6612 (1.1); 8.6552 (0.8); 7.8869 (0.5); 7.8612 (0.8); 7.8253 (0.5); 4.0381 (1.3); 4.0203 (1.3); 3.3183 (16.0); 2.5100 (29.4); 2.5059 (55.4); 2.5015 (70.8); 2.4970 (50.4); 2.4928 (24.6); 2.1366 (0.7); 1.9887 (5.6); 1.1925 (1.5); 1.1747 (3.0); 1.1570 (1.5); -0.0002 (37.1); -0.0084 (2.1) I.1-387: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0875 (0.5); 9.0705 (0.5); 8.6909 (1.2); 8.6847 (1.6); 8.6586 (1.3); 8.6523 (1.0); 7.9244 (0.6); 7.8872 (0.9); 7.8395 (0.5); 7.8219 (0.6); 7.7987 (0.9); 7.7780 (0.6); 4.0557 (0.6); 4.0381 (1.7); 4.0203 (1.8); 4.0025 (0.6); 3.3180 (16.0); 2.6703 (0.5); 2.5058 (69.1); 2.5014 (88.4); 2.4970 (63.2); 2.4928 (31.1); 2.3330 (0.6); 2.3286 (0.7); 2.1394 (0.9); 1.9887 (7.3); 1.1925 (2.0); 1.1747 (3.9); 1.1569 (2.0); -0.0002 (52.3); -0.0083 (2.8) BCS241005-Ausland STR 179 I.1-388: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6852 (0.8); 8.6791 (1.0); 8.6501 (0.8); 8.6442 (0.6); 7.3470 (0.5); 4.0376 (0.9); 4.0200 (0.9); 3.3165 (16.0); 2.6695 (0.7); 2.5229 (2.3); 2.5093 (48.8); 2.5052 (93.3); 2.5008 (120.6); 2.4964 (86.7); 2.4920 (43.0); 2.3784 (2.9); 2.3278 (0.9); 2.1397 (0.5); 1.9883 (4.0); 1.1922 (1.0); 1.1744 (2.1); 1.1567 (1.0); -0.0002 (64.2); -0.0084 (3.6) I.1-389: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.0134 (0.8); 9.1039 (1.4); 9.0869 (1.4); 8.6960 (2.8); 8.6899 (3.9); 8.6616 (3.1); 8.6556 (2.4); 7.9425 (1.4); 7.8850 (1.4); 7.8445 (1.2); 7.8240 (1.3); 7.7554 (2.1); 7.7179 (1.2); 4.0560 (1.1); 4.0382 (3.5); 4.0204 (3.6); 4.0027 (1.2); 3.6014 (0.7); 3.3181 (16.0); 2.6704 (0.8); 2.5101 (57.0); 2.5060 (109.1); 2.5017 (141.4); 2.4972 (101.8); 2.4930 (50.5); 2.3288 (1.0); 2.1370 (2.0); 1.9889 (15.1); 1.9090 (0.7); 1.7600 (0.9); 1.4157 (0.9); 1.3554 (1.0); 1.1926 (4.0); 1.1748 (8.1); 1.1571 (4.0); -0.0002 (73.5); -0.0084 (4.0) I.1-390: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6309 (2.7); 8.6248 (3.3); 8.5861 (3.2); 8.5801 (2.4); 8.2310 (3.6); 8.2102 (4.0); 7.7711 (5.1); 7.7507 (4.6); 7.6031 (0.7); 7.5973 (0.7); 7.5913 (0.8); 7.5823 (0.9); 7.5762 (0.9); 7.5702 (0.9); 7.5644 (0.7); 7.2625 (18.8); 7.2398 (1.1); 7.2207 (1.0); 7.0654 (1.3); 7.0441 (1.6); 7.0409 (1.5); 7.0196 (1.2); 5.6932 (0.9); 5.6754 (1.1); 5.6570 (0.9); 3.9708 (16.0); 3.2683 (0.9); 3.2511 (1.2); 3.2340 (0.9); 1.5754 (14.8); 1.4142 (6.3); 1.3975 (6.3); 1.2887 (10.9); 1.2714 (10.8); - 0.0002 (19.9); -0.0083 (1.0) I.1-391: 1H-NMR(400.6 MHz, CDCl3): δ= 8.2112 (0.5); 7.7619 (0.5); 7.2618 (17.1); 3.9721 (1.9); 1.5539 (16.0); 1.4159 (0.8); 1.3994 (0.8); 1.2727 (1.9); 1.2554 (1.9); -0.0002 (18.1) I.1-392: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6346 (2.8); 8.6291 (3.3); 8.5861 (3.3); 8.5803 (2.6); 8.2315 (3.9); 8.2110 (4.3); 8.0107 (0.7); 7.7918 (2.9); 7.7866 (2.9); 7.7692 (4.3); 7.7488 (4.0); 7.5140 (1.2); 7.4933 (1.9); 7.4885 (1.7); 7.4461 (0.6); 7.4262 (0.6); 7.4051 (3.2); 7.3846 (2.3); 7.2613 (106.0); 6.9977 (0.7); 5.6954 (0.9); 5.6781 (1.3); 5.6595 (1.1); 3.9713 (16.0); 3.7852 (0.6); 3.4592 (0.6); 3.4413 (1.2); 3.4250 (1.4); 3.4078 (1.1); 1.5487 (11.5); 1.5104 (2.1); 1.4160 (6.8); 1.3991 (6.6); 1.2942 (4.1); 1.2815 (11.4); 1.2650 (10.9); 0.1450 (0.8); -0.0002 (131.8); -0.1491 (0.8) I.1-393: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6810 (2.5); 8.6750 (3.6); 8.6561 (3.5); 8.6501 (2.2); 8.0347 (1.5); 8.0312 (1.5); 8.0150 (1.7); 8.0114 (1.6); 7.9229 (1.5); 7.9195 (1.4); 7.8980 (1.5); 7.8946 (1.3); 7.8255 (2.9); 7.6298 (1.2); 7.6111 (1.9); 7.5922 (1.3); 7.5804 (2.1); 7.5138 (2.0); 7.2611 (14.9); 5.3442 (0.8); 5.3270 (1.1); 5.3093 (0.8); 3.9806 (16.0); 1.5639 (13.0); 1.4465 (5.0); 1.4298 (5.0); 1.2657 (0.8); 0.8819 (0.9); -0.0002 (16.5); -0.0083 (0.9) I.1-394: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6752 (1.9); 8.6694 (2.4); 8.6396 (2.4); 8.6336 (1.7); 8.0310 (1.1); 8.0109 (1.2); 7.9212 (1.1); 7.8965 (1.1); 7.7767 (1.6); 7.6498 (1.0); 7.6451 (0.9); 7.6291 (1.6); BCS241005-Ausland STR 180 7.6244 (1.4); 7.6143 (1.5); 7.5959 (0.8); 7.5499 (2.2); 7.5292 (1.5); 7.2607 (18.8); 5.3546 (0.6); 5.3379 (0.9); 5.3201 (0.6); 3.9797 (11.1); 1.5527 (16.0); 1.4434 (3.9); 1.4268 (3.9); 1.2629 (0.5); -0.0002 (21.3) I.1-395: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6642 (2.4); 8.6584 (4.0); 8.6481 (4.2); 8.6429 (2.2); 8.0293 (1.8); 8.0091 (2.0); 7.9163 (1.9); 7.8912 (1.9); 7.6476 (1.3); 7.6288 (2.2); 7.6093 (1.2); 7.4985 (3.1); 7.4188 (2.5); 7.2605 (22.0); 7.2594 (22.1); 7.2117 (1.0); 7.1577 (2.6); 5.3525 (1.0); 5.3350 (1.4); 5.3180 (1.0); 3.9775 (16.0); 2.4208 (13.6); 1.5523 (11.6); 1.4544 (6.2); 1.4376 (6.0); -0.0002 (25.8); -0.0014 (25.2) I.1-396: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6811 (2.5); 8.6751 (3.5); 8.6550 (3.6); 8.6490 (2.3); 8.0348 (1.5); 8.0316 (1.6); 8.0150 (1.7); 8.0117 (1.7); 7.9231 (1.6); 7.8980 (1.6); 7.6802 (2.9); 7.6296 (1.3); 7.6108 (2.0); 7.5920 (1.2); 7.5386 (2.2); 7.3627 (2.1); 7.2615 (10.6); 5.3471 (0.8); 5.3296 (1.2); 5.3122 (0.8); 3.9807 (16.0); 1.5734 (9.3); 1.4453 (5.4); 1.4286 (5.3); 1.2649 (0.8); 0.8817 (0.8); -0.0002 (11.6); - 0.0081 (0.6) I.1-397: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1164 (1.1); 9.0994 (1.1); 8.7611 (2.3); 8.7550 (2.7); 8.7040 (2.8); 8.6978 (2.3); 8.0130 (2.4); 7.8624 (1.2); 7.8588 (1.2); 7.8426 (3.2); 7.8393 (2.8); 7.7614 (1.0); 7.7362 (1.0); 7.6965 (1.0); 7.6783 (2.9); 7.6587 (0.8); 5.1185 (0.6); 5.1010 (0.9); 5.0838 (0.6); 4.0568 (1.2); 4.0389 (3.7); 4.0212 (3.8); 4.0034 (1.4); 3.6020 (1.0); 3.3220 (11.9); 2.5114 (22.4); 2.5074 (42.2); 2.5030 (54.2); 2.4986 (38.8); 2.4944 (19.3); 1.9896 (16.0); 1.9101 (0.6); 1.7602 (1.1); 1.5056 (4.0); 1.4885 (4.0); 1.3563 (1.6); 1.1932 (4.2); 1.1754 (8.4); 1.1576 (4.2); -0.0002 (16.8); -0.0084 (1.0) I.1-398: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0881 (0.5); 8.7500 (0.9); 8.6967 (0.9); 7.8501 (1.9); 7.8298 (1.3); 7.7699 (0.9); 7.7515 (1.0); 7.7258 (0.5); 7.6763 (0.6); 3.3172 (16.0); 2.6662 (1.2); 2.5018 (58.8); 2.4978 (56.2); 1.9888 (1.1); 1.9855 (1.0); 1.5014 (1.8); 1.4847 (1.6); 1.1747 (0.6); 1.1713 (0.6); - 0.0002 (14.5); -0.0036 (14.0) I.1-399: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7433 (0.5); 8.6915 (0.6); 3.3184 (16.0); 2.5056 (37.6); 2.5012 (47.7); 2.4968 (33.9); 2.3591 (1.9); 1.4969 (0.8); 1.4797 (0.8); -0.0002 (17.1); -0.0084 (0.9) I.1-400: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7605 (0.9); 8.7544 (1.1); 8.7034 (1.1); 8.6973 (0.9); 7.8768 (0.6); 7.8730 (0.9); 7.8692 (0.6); 7.8577 (0.5); 7.8380 (0.6); 7.8344 (0.6); 7.7336 (0.8); 7.6741 (0.6); 7.6541 (0.8); 3.3201 (16.0); 2.5103 (18.5); 2.5062 (35.0); 2.5018 (44.9); 2.4973 (32.0); 2.4930 (15.7); 1.9889 (1.1); 1.9090 (0.8); 1.5063 (1.6); 1.4891 (1.6); 1.3554 (0.6); 1.1748 (0.6); -0.0002 (16.6); - 0.0084 (0.9) BCS241005-Ausland STR 181 I.1-401: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6490 (2.7); 8.6430 (3.2); 8.5940 (3.2); 8.5880 (2.6); 8.2309 (3.9); 8.2104 (4.3); 7.7358 (4.2); 7.7154 (3.9); 7.3414 (2.9); 7.3369 (3.0); 7.3224 (3.4); 7.2610 (15.5); 6.9781 (0.7); 6.9622 (0.9); 6.9567 (1.4); 6.9508 (0.8); 6.9408 (0.5); 6.9351 (0.7); 5.6688 (1.0); 5.6512 (1.3); 5.6329 (1.0); 3.9736 (16.0); 1.5607 (9.3); 1.4046 (6.8); 1.3879 (6.9); 1.2631 (0.7); 0.8821 (0.7); - 0.0002 (19.3) I.1-402: 1H-NMR(300.0 MHz, d6-DMSO): δ= 13.5388 (0.8); 13.5301 (0.8); 9.1164 (4.4); 9.0946 (4.6); 8.7045 (8.0); 8.6965 (11.9); 8.6652 (12.2); 8.6571 (8.9); 8.0695 (9.6); 8.0632 (10.3); 7.9110 (7.2); 7.8844 (9.5); 7.8259 (9.8); 7.8212 (10.9); 7.7946 (3.5); 7.7881 (3.2); 7.7665 (6.9); 7.7601 (7.0); 7.7289 (6.2); 7.7235 (6.5); 7.7176 (13.7); 7.7025 (4.9); 7.6972 (4.9); 7.6896 (6.7); 7.5611 (0.4); 7.5227 (0.4); 5.7577 (2.1); 5.3219 (0.6); 5.2999 (2.7); 5.2776 (4.2); 5.2551 (2.8); 5.2329 (0.6); 4.0942 (0.8); 3.5087 (1.0); 3.3234 (4.6); 3.1695 (14.2); 2.7291 (0.3); 2.5030 (45.4); 1.4775 (16.0); 1.4546 (15.8); 1.2332 (0.7); - 0.0002 (13.0) I.1-405: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1093 (0.8); 9.0388 (2.5); 9.0226 (2.6); 8.6834 (4.4); 8.6774 (6.3); 8.6590 (6.7); 8.6530 (4.5); 8.0705 (6.4); 8.0499 (7.6); 7.7900 (7.3); 7.7693 (6.4); 7.5223 (4.1); 7.5066 (4.1); 7.4578 (1.0); 7.4521 (1.3); 7.4351 (1.8); 7.4294 (2.4); 7.4125 (1.0); 7.4069 (1.3); 5.3174 (1.6); 5.3007 (2.5); 5.2836 (1.7); 3.3273 (16.0); 2.5079 (57.8); 2.5037 (71.5); 2.4996 (52.8); 2.3307 (0.5); 1.4685 (9.3); 1.4514 (9.3); -0.0002 (15.4) I.1-406: 1H-NMR(400.6 MHz, CDCl3): δ= 13.2487 (5.2); 8.6784 (2.9); 8.6728 (3.2); 8.6058 (3.3); 8.6000 (2.7); 8.2398 (4.1); 8.2196 (4.5); 7.7028 (4.9); 7.6825 (4.8); 7.3621 (2.5); 7.3406 (2.8); 7.2625 (10.8); 7.0160 (2.9); 6.9948 (2.6); 5.6713 (1.0); 5.6536 (1.5); 5.6361 (1.0); 3.9801 (16.0); 2.0475 (0.8); 1.5797 (9.8); 1.4095 (7.0); 1.3929 (7.0); 1.2606 (0.9); -0.0002 (12.3) I.1-407: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.6554 (2.9); 13.1202 (3.0); 9.4879 (1.5); 9.4739 (1.5); 8.7022 (4.0); 8.6967 (7.2); 8.6886 (7.1); 8.6829 (3.6); 8.0680 (6.3); 8.0477 (7.2); 8.0049 (3.5); 7.9830 (3.7); 7.7516 (7.1); 7.7314 (6.3); 7.1962 (3.2); 7.1745 (3.1); 5.3776 (1.6); 5.3609 (2.5); 5.3439 (1.6); 3.3412 (16.0); 2.6733 (0.6); 2.5050 (90.8); 2.3325 (0.9); 1.5044 (9.1); 1.4873 (9.1); 1.3559 (1.2); 1.2314 (0.6); 1.1819 (0.8); -0.0002 (12.4) I.1-408: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6459 (0.9); 8.6402 (1.0); 8.5958 (1.1); 8.5898 (0.8); 8.2289 (1.3); 8.2083 (1.4); 7.7360 (1.4); 7.7156 (1.3); 7.4975 (1.0); 7.4931 (1.0); 7.3853 (1.1); 7.3812 (0.9); 7.2606 (16.3); 5.9916 (0.8); 3.9721 (5.1); 1.5521 (16.0); 1.4026 (2.1); 1.3860 (2.2); -0.0002 (15.6) I.1-409: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1038 (0.5); 10.9317 (0.6); 8.9838 (1.1); 8.9674 (1.1); 8.6782 (1.8); 8.6723 (2.5); 8.6534 (2.7); 8.6475 (1.7); 8.0761 (2.6); 8.0557 (3.1); 7.7903 (3.0); 7.7699 BCS241005-Ausland STR 182 (2.6); 7.5570 (2.2); 7.5525 (2.1); 7.3083 (2.2); 7.3039 (2.0); 5.2814 (0.6); 5.2639 (1.0); 5.2473 (0.7); 3.3194 (16.0); 2.6703 (0.6); 2.5057 (80.6); 2.5016 (100.4); 2.4974 (72.8); 2.3288 (0.8); 1.4388 (3.7); 1.4216 (3.7); -0.0002 (29.2) I.1-410: 1H-NMR(400.6 MHz, CDCl3): δ= 12.2773 (5.5); 8.6797 (2.7); 8.6737 (3.3); 8.6308 (3.2); 8.6248 (2.5); 8.2371 (3.8); 8.2164 (4.0); 7.7081 (4.1); 7.6874 (3.7); 7.5347 (5.8); 7.5143 (0.9); 7.2611 (11.9); 7.1052 (5.4); 5.6547 (0.9); 5.6374 (1.2); 5.6192 (0.9); 3.9772 (16.0); 1.5724 (12.5); 1.4140 (6.4); 1.3974 (6.5); -0.0002 (13.4); -0.0081 (0.8) I.1-411: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2948 (1.2); 9.2777 (1.3); 8.7180 (2.1); 8.7121 (3.7); 8.7008 (3.9); 8.6949 (2.1); 8.1103 (5.0); 8.0881 (3.7); 8.0678 (4.2); 7.7554 (4.0); 7.7351 (3.6); 7.1558 (5.2); 5.7575 (1.1); 5.3766 (0.9); 5.3595 (1.3); 5.3425 (0.9); 3.3279 (16.0); 2.5077 (39.0); 2.5037 (48.7); 2.4997 (35.4); 1.4622 (5.1); 1.4453 (5.1); -0.0002 (8.4) I.1-412: 1H-NMR(400.6 MHz, CDCl3): δ= 8.8921 (1.1); 8.8879 (1.0); 8.7009 (1.0); 8.6953 (1.0); 8.6596 (1.1); 8.6537 (1.2); 8.5966 (1.2); 8.5908 (1.0); 8.2371 (1.5); 8.2165 (1.6); 8.1272 (0.7); 8.1219 (1.0); 8.1168 (0.6); 7.7356 (1.6); 7.7148 (1.5); 7.2605 (19.0); 3.9766 (6.0); 1.5493 (16.0); 1.4226 (2.6); 1.4059 (2.5); -0.0002 (21.9) I.1-413: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6657 (1.8); 8.6597 (2.1); 8.5984 (2.0); 8.5924 (1.7); 8.5307 (1.6); 8.5180 (1.7); 8.2363 (2.5); 8.2158 (2.8); 7.7252 (2.7); 7.7046 (2.6); 7.6898 (2.2); 7.5830 (1.2); 7.5704 (1.2); 7.4796 (0.6); 7.4604 (0.6); 7.2616 (14.6); 5.6745 (0.6); 5.6566 (0.8); 5.6386 (0.6); 3.9772 (10.5); 1.5702 (16.0); 1.5689 (16.0); 1.4146 (4.4); 1.3979 (4.4); 1.2600 (0.5); -0.0002 (13.7) I.1-414: 1H-NMR(400.6 MHz, d6-DMSO):δ= 9.2834 (1.1); 9.2671 (1.2); 8.6927 (2.0); 8.6866 (3.2); 8.6694 (3.4); 8.6633 (2.2); 8.5162 (2.0); 8.5035 (2.1); 8.0690 (3.1); 8.0484 (3.7); 7.8120 (2.6); 7.7783 (3.6); 7.7577 (3.1); 7.6996 (1.6); 7.6963 (1.4); 7.6870 (1.6); 7.6835 (1.4); 5.3254 (0.7); 5.3085 (1.2); 5.2916 (0.8); 3.3264 (16.0); 2.5248 (0.9); 2.5111 (23.1); 2.5070 (44.7); 2.5027 (58.1); 2.4982 (42.0); 2.4941 (21.2); 1.4781 (4.3); 1.4609 (4.4); -0.0002 (12.3); -0.0083 (0.7) I.1-415: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8511 (0.6); 8.8466 (0.6); 8.7515 (0.6); 8.7456 (0.6); 8.6930 (0.5); 8.6870 (0.8); 8.6675 (0.8); 8.6615 (0.5); 8.2468 (0.6); 8.0694 (0.8); 8.0491 (0.9); 7.7893 (0.8); 7.7689 (0.8); 3.3234 (16.0); 2.5061 (15.5); 2.5018 (19.8); 2.4975 (14.1); 1.4808 (1.1); 1.4636 (1.0); -0.0002 (4.6) I.1-416: 1H-NMR(400.6 MHz, CDCl3): δ= 9.3388 (4.4); 9.1487 (10.4); 8.6692 (2.8); 8.6632 (3.1); 8.5932 (3.1); 8.5872 (2.5); 8.2424 (3.7); 8.2216 (4.0); 7.7365 (4.0); 7.7158 (3.7); 7.5103 (0.8); 7.4912 BCS241005-Ausland STR 183 (0.8); 7.2632 (10.6); 5.7159 (0.9); 5.6982 (1.2); 5.6799 (0.9); 4.1310 (0.7); 4.1130 (0.7); 3.9785 (16.0); 2.0455 (3.1); 1.6055 (11.4); 1.4315 (6.6); 1.4148 (6.6); 1.2773 (0.8); 1.2595 (1.7); 1.2417 (0.8); -0.0002 (12.0); -0.0083 (0.7) I.1-418: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6479 (1.0); 8.6418 (1.3); 8.5882 (1.1); 8.5821 (0.9); 8.2328 (1.3); 8.2116 (1.5); 7.7425 (1.5); 7.7260 (0.5); 7.7214 (1.4); 7.2984 (0.7); 7.2754 (0.7); 7.2606 (20.0); 7.2536 (0.6); 3.9733 (6.8); 1.5494 (16.0); 1.4126 (2.3); 1.3959 (2.3); 0.0079 (0.7); -0.0002 (23.6); -0.0085 (0.7) I.1-419: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6447 (2.5); 8.6386 (3.2); 8.5970 (2.7); 8.5909 (2.1); 8.2352 (3.2); 8.2305 (1.0); 8.2187 (1.1); 8.2139 (3.5); 8.2097 (0.5); 7.7613 (0.6); 7.7571 (3.5); 7.7523 (1.1); 7.7404 (1.3); 7.7357 (4.3); 7.5227 (1.3); 7.3802 (1.3); 7.3288 (0.6); 7.3093 (0.6); 7.2622 (7.9); 6.7649 (0.8); 6.7376 (0.9); 6.7210 (0.9); 6.6938 (0.9); 5.8805 (2.2); 5.8367 (2.0); 5.6931 (0.7); 5.6761 (0.8); 5.6739 (0.8); 5.6568 (0.7); 5.4370 (2.1); 5.4097 (2.0); 3.9727 (16.0); 1.5998 (6.7); 1.4269 (5.2); 1.4101 (5.2); -0.0002 (9.2) I.1-420: 1H-NMR(300.0 MHz, d6-DMSO): δ= 13.5173 (2.4); 9.2135 (4.6); 9.1919 (4.8); 8.7129 (7.7); 8.7050 (11.2); 8.6739 (11.3); 8.6660 (8.2); 7.9559 (9.8); 7.9107 (7.5); 7.8842 (9.9); 7.8351 (0.4); 7.8074 (10.2); 7.8032 (10.8); 7.7507 (7.7); 7.7224 (11.6); 7.6953 (4.7); 7.6905 (4.5); 6.5801 (0.5); 5.3389 (0.6); 5.3171 (2.7); 5.2947 (4.2); 5.2722 (2.8); 5.2496 (0.6); 3.3208 (22.7); 2.7284 (0.4); 2.5077 (40.1); 2.5024 (51.8); 2.4973 (38.0); 2.2713 (0.4); 1.9092 (0.3); 1.7545 (0.5); 1.6037 (0.4); 1.5799 (0.4); 1.4916 (16.0); 1.4688 (15.8); 1.3693 (0.3); 1.3556 (1.4); 1.2707 (1.0); 1.2338 (1.6); 1.1853 (0.9); 1.1694 (4.3); 1.0842 (0.6); 0.8521 (0.4); 0.1950 (0.4); -0.0001 (68.2) I.1-421: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.1030 (1.4); 9.0811 (1.5); 8.7210 (2.9); 8.7130 (3.9); 8.6761 (4.1); 8.6680 (3.1); 8.0533 (3.3); 8.0469 (3.4); 7.9389 (2.7); 7.9122 (3.6); 7.8665 (3.5); 7.8615 (3.7); 7.7881 (1.2); 7.7815 (1.1); 7.7594 (4.2); 7.7534 (4.4); 7.7321 (1.7); 7.7268 (1.7); 7.7144 (4.4); 7.6864 (2.0); 5.3196 (0.9); 5.2971 (1.4); 5.2746 (0.9); 3.9052 (16.0); 3.3429 (0.8); 2.5178 (2.2); 2.5126 (2.8); 2.0855 (3.6); 1.7692 (0.4); 1.4904 (5.3); 1.4675 (5.2); -0.0002 (1.2) I.1-422: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.1828 (1.3); 9.1605 (1.4); 8.7230 (2.8); 8.7149 (3.9); 8.6796 (4.1); 8.6715 (3.0); 7.9319 (2.1); 7.9264 (3.4); 7.9212 (4.8); 7.8944 (3.5); 7.8296 (3.3); 7.8246 (3.6); 7.7496 (2.2); 7.7362 (2.3); 7.7307 (2.0); 7.7091 (2.8); 7.7042 (3.6); 5.3281 (0.9); 5.3057 (1.3); 5.2831 (0.8); 3.8918 (16.0); 3.3215 (14.6); 3.2986 (0.3); 2.5081 (17.0); 2.5028 (21.6); 2.1837 (0.4); 1.4960 (5.1); 1.4731 (5.0); 1.3560 (2.5); 1.2335 (0.4); 0.0107 (0.5); -0.0001 (11.1); -0.0111 (0.4) BCS241005-Ausland STR 184 I.1-423: 1H-NMR(300.1 MHz, d6-DMSO): δ= 8.9571 (1.6); 8.9411 (1.7); 8.6739 (3.7); 8.6400 (4.3); 7.8186 (2.3); 7.7234 (3.1); 7.6642 (0.5); 7.5855 (4.2); 7.5107 (0.5); 7.4323 (2.2); 7.4062 (1.8); 5.0518 (0.9); 3.8855 (16.0); 3.8181 (5.2); 3.6347 (1.0); 3.3281 (12.8); 2.5027 (26.6); 1.4795 (3.4); 1.3658 (0.9); - 0.0002 (19.9) I.1-424: 1H-NMR(300.1 MHz, d6-DMSO): δ= 13.2256 (0.4); 13.1203 (2.5); 8.9786 (6.1); 8.9570 (6.2); 8.6641 (13.4); 8.6378 (16.0); 7.8541 (7.8); 7.7193 (12.2); 7.6329 (6.7); 7.6045 (11.4); 7.5813 (15.3); 7.5064 (0.7); 7.4287 (6.4); 7.4046 (5.8); 5.2079 (0.7); 5.0235 (2.9); 3.8094 (15.4); 3.6411 (2.7); 3.5136 (0.4); 3.4694 (0.3); 3.3238 (14.1); 3.2155 (0.4); 2.5099 (40.6); 2.5044 (50.8); 2.4991 (37.7); 2.2740 (0.3); 2.0765 (1.0); 1.4774 (10.6); 1.3443 (2.6); 1.2331 (0.6); -0.0001 (64.4) I.1-425: 1H-NMR(300.1 MHz, d6-DMSO): δ= 8.8365 (0.8); 8.6629 (2.2); 8.6311 (2.7); 7.9259 (1.3); 7.6661 (2.9); 7.6125 (2.0); 7.5867 (3.8); 7.4519 (0.9); 7.4276 (0.9); 5.0065 (0.5); 3.8933 (16.0); 3.8165 (2.7); 3.7784 (1.0); 3.6658 (0.5); 3.3190 (5.5); 2.5079 (9.3); 2.5024 (11.7); 2.4970 (8.6); 1.4638 (1.8); 1.3463 (0.5); -0.0002 (16.4) I.1-426: 1H-NMR(300.1 MHz, d6-DMSO): δ= 13.3121 (0.4); 13.1647 (1.2); 13.1497 (1.2); 13.0202 (0.5); 12.9195 (0.4); 12.5217 (0.4); 9.9797 (0.4); 8.8562 (3.4); 8.6534 (8.4); 8.6263 (9.6); 8.5501 (0.4); 8.1736 (0.5); 7.9586 (5.2); 7.6770 (10.4); 7.6174 (8.1); 7.5927 (16.0); 7.4363 (3.6); 7.4151 (3.5); 5.1864 (0.7); 5.1134 (0.4); 4.9832 (2.0); 3.8041 (10.1); 3.6853 (1.9); 3.6705 (2.0); 3.5221 (0.4); 3.4631 (0.5); 3.3177 (7.3); 3.1512 (0.4); 3.0648 (0.4); 2.7274 (0.5); 2.5079 (52.0); 2.5022 (65.5); 2.4967 (47.8); 2.3843 (0.5); 2.2818 (0.5); 1.7558 (0.4); 1.6824 (0.4); 1.5533 (0.5); 1.4623 (7.1); 1.3219 (1.9); 1.2342 (0.8); 0.1954 (0.5); 0.0694 (0.7); -0.0001 (100.9); -0.0112 (4.8); -0.1978 (0.4) I.1-427: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0954 (0.8); 9.0788 (0.9); 8.6817 (1.9); 8.6756 (3.0); 8.6588 (3.4); 8.6526 (2.2); 8.0626 (2.6); 8.0580 (0.9); 8.0461 (1.0); 8.0414 (3.3); 7.9858 (0.6); 7.9668 (1.2); 7.9615 (0.6); 7.9550 (0.7); 7.9450 (0.6); 7.9395 (0.5); 7.9335 (0.6); 7.7920 (3.0); 7.7874 (0.9); 7.7755 (0.9); 7.7709 (2.7); 7.6134 (1.0); 7.5916 (1.0); 7.5881 (1.0); 7.5665 (0.8); 5.3309 (0.6); 5.3139 (0.9); 5.2971 (0.6); 4.0561 (0.6); 4.0383 (2.0); 4.0206 (2.0); 4.0028 (0.7); 3.3209 (16.0); 2.5248 (1.1); 2.5201 (1.7); 2.5113 (23.2); 2.5067 (49.5); 2.5022 (68.3); 2.4976 (47.1); 2.4931 (20.8); 1.9937 (1.0); 1.9891 (9.3); 1.9093 (2.4); 1.4722 (3.4); 1.4549 (3.4); 1.3556 (1.2); 1.1927 (2.6); 1.1749 (5.4); 1.1695 (0.5); 1.1571 (2.6); 0.0080 (1.3); -0.0002 (42.2); -0.0085 (1.1) I.1-428: 1H-NMR(400.6 MHz, CDCl3): δ= 8.8453 (0.8); 8.8415 (1.3); 8.8378 (0.7); 8.6603 (1.7); 8.6543 (2.0); 8.6099 (1.3); 8.6029 (1.4); 8.5954 (1.7); 8.5893 (1.4); 8.2382 (2.1); 8.2335 (0.6); 8.2217 (0.7); 8.2169 (2.3); 7.8815 (0.5); 7.8790 (0.5); 7.8598 (0.5); 7.7379 (2.2); 7.7331 (0.7); 7.7213 (0.7); 7.7166 BCS241005-Ausland STR 185 (2.0); 7.2613 (20.1); 5.6858 (0.5); 3.9768 (10.7); 2.0455 (1.2); 1.5636 (16.0); 1.4251 (3.5); 1.4084 (3.5); 1.2596 (0.7); 0.0080 (0.8); -0.0002 (23.9); -0.0085 (0.6) I.1-429: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8176 (0.6); 8.8135 (1.1); 8.8095 (0.6); 8.7136 (1.0); 8.7066 (1.0); 8.6926 (1.0); 8.6865 (1.6); 8.6674 (1.7); 8.6613 (1.1); 8.0715 (1.4); 8.0549 (0.5); 8.0503 (2.0); 8.0457 (0.6); 7.7953 (1.6); 7.7907 (0.5); 7.7743 (1.4); 3.3262 (16.0); 2.5204 (0.6); 2.5115 (8.6); 2.5071 (18.3); 2.5025 (25.2); 2.4980 (17.5); 2.4934 (7.8); 1.4839 (1.9); 1.4666 (1.9); -0.0002 (7.7) I.1-430: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6769 (8.6); 8.6708 (10.7); 8.6226 (9.4); 8.6165 (7.7); 8.2671 (10.1); 8.2626 (3.4); 8.2506 (3.5); 8.2460 (11.8); 7.7810 (13.9); 7.7767 (10.9); 7.7650 (3.6); 7.7605 (10.8); 7.5560 (4.9); 7.5429 (2.8); 7.5232 (2.7); 7.3919 (4.6); 7.2606 (106.6); 6.9970 (0.6); 6.7720 (2.8); 6.7447 (3.1); 6.7282 (3.2); 6.7008 (3.2); 5.8932 (7.5); 5.8493 (6.7); 5.7745 (0.5); 5.7579 (2.2); 5.7390 (2.6); 5.7216 (2.2); 5.7048 (0.5); 5.4437 (7.2); 5.4164 (7.0); 3.7534 (1.2); 1.8737 (0.6); 1.8654 (0.6); 1.8571 (1.5); 1.8486 (0.6); 1.8405 (0.7); 1.4928 (16.0); 1.4761 (16.0); 1.4322 (1.3); 1.2425 (1.3); 1.2225 (0.5); 0.0080 (3.6); -0.0002 (130.0); -0.0084 (4.0); -0.0383 (0.5) I.1-431: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6573 (2.5); 8.6513 (2.9); 8.6062 (2.9); 8.6003 (2.3); 8.2789 (3.9); 8.2689 (5.2); 8.2584 (4.1); 8.0295 (2.0); 7.7868 (3.7); 7.7661 (3.4); 7.3331 (0.9); 7.3115 (1.0); 7.2621 (25.0); 5.6531 (1.0); 5.6337 (0.9); 4.5448 (1.4); 4.5413 (1.5); 4.5345 (2.3); 4.5286 (2.1); 4.5214 (1.6); 3.7829 (2.4); 3.7711 (3.2); 3.7595 (2.2); 3.4641 (16.0); 1.8069 (0.9); 1.7914 (1.2); 1.7752 (1.5); 1.7573 (1.0); 1.5661 (3.5); 1.2547 (2.7); 0.7701 (2.9); 0.7517 (6.0); 0.7332 (2.6); 0.0696 (0.6); -0.0002 (31.1); -0.0082 (1.5) I.1-432: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6573 (1.8); 8.6512 (2.3); 8.6103 (1.9); 8.6042 (1.5); 8.2664 (2.2); 8.2419 (2.1); 8.2372 (0.7); 8.2254 (0.8); 8.2207 (2.4); 8.0293 (1.0); 7.7941 (2.3); 7.7893 (0.7); 7.7775 (0.7); 7.7729 (2.0); 7.2611 (22.7); 3.9743 (0.6); 3.9562 (0.8); 3.9522 (1.0); 3.9345 (1.0); 3.8312 (0.6); 3.8124 (0.5); 3.7472 (0.5); 3.7333 (0.5); 1.8198 (0.6); 1.8042 (0.7); 1.7885 (1.0); 1.7704 (0.7); 1.5620 (16.0); 0.7773 (1.6); 0.7589 (3.7); 0.7402 (1.5); 0.0080 (0.8); -0.0002 (27.5); -0.0085 (0.8) I.1-433: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6572 (1.6); 8.6517 (2.3); 8.6403 (0.8); 8.6091 (1.6); 8.6032 (1.3); 8.3264 (1.9); 8.3059 (2.1); 8.2646 (2.8); 8.0266 (1.2); 7.8079 (2.0); 7.7873 (1.9); 7.7619 (0.8); 7.7582 (0.8); 7.7431 (0.5); 7.5128 (0.9); 7.4933 (0.8); 7.3238 (0.5); 7.3034 (0.6); 7.2914 (0.6); 7.2608 (17.1); 5.6561 (0.6); 5.6369 (0.6); 5.5467 (2.1); 5.5369 (2.0); 1.8164 (0.5); 1.8010 (0.7); 1.7844 (0.9); 1.7669 (0.6); 1.5629 (16.0); 1.2648 (0.6); 0.8820 (0.6); 0.7753 (1.6); 0.7570 (3.3); 0.7384 (1.5); -0.0002 (16.1) BCS241005-Ausland STR 186 I.1-434: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6644 (1.4); 8.6584 (1.7); 8.6258 (1.6); 8.6198 (1.2); 8.2770 (2.0); 8.2610 (3.2); 8.2566 (2.8); 8.0323 (1.1); 7.8515 (2.0); 7.8307 (1.8); 7.2814 (0.5); 7.2607 (19.4); 5.6210 (0.6); 5.6006 (0.5); 5.0248 (5.5); 1.8223 (0.5); 1.8181 (0.5); 1.8044 (0.7); 1.7995 (0.8); 1.7867 (0.5); 1.7814 (0.6); 1.5543 (16.0); 1.2623 (0.6); 0.8820 (0.6); 0.7809 (1.6); 0.7624 (3.3); 0.7438 (1.5); - 0.0002 (18.1); -0.0083 (1.1) I.1-435: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6505 (4.9); 8.6458 (5.6); 8.6040 (5.8); 8.5981 (4.5); 8.2620 (11.2); 8.2268 (7.1); 8.2067 (7.8); 8.0278 (4.8); 7.7784 (7.7); 7.7582 (7.1); 7.3060 (2.3); 7.2843 (2.8); 7.2605 (69.9); 7.2590 (67.1); 6.3689 (0.6); 5.6605 (1.0); 5.6438 (2.2); 5.6235 (2.2); 5.6072 (1.0); 4.6682 (4.0); 4.6524 (8.2); 4.6367 (4.3); 4.2436 (2.2); 4.2264 (7.0); 4.2086 (7.1); 4.1911 (2.8); 4.1761 (0.6); 2.8384 (4.3); 2.8224 (8.6); 2.8066 (4.3); 1.8273 (0.9); 1.8098 (2.0); 1.7935 (3.3); 1.7764 (3.7); 1.7582 (2.3); 1.7408 (1.0); 1.5487 (14.8); 1.3066 (8.2); 1.2900 (16.0); 1.2709 (10.3); 0.8976 (2.3); 0.8811 (5.2); 0.8638 (2.6); 0.7708 (5.9); 0.7524 (12.3); 0.7342 (5.8); -0.0002 (86.8); -0.0016 (85.0); -0.1515 (0.7) I.1-436: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6718 (0.7); 8.6658 (0.8); 8.6209 (0.8); 8.6148 (0.6); 8.2197 (0.8); 8.1984 (1.0); 7.9058 (0.6); 7.9007 (0.7); 7.7349 (0.9); 7.7137 (0.9); 7.5327 (0.8); 7.5119 (0.6); 7.2609 (12.4); 3.9742 (4.4); 1.5558 (16.0); -0.0002 (14.6) I.1-437: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6557 (1.9); 8.6496 (2.3); 8.6017 (2.0); 8.5956 (1.6); 8.2550 (2.2); 8.2504 (0.8); 8.2385 (0.8); 8.2338 (2.6); 7.7375 (2.4); 7.7329 (0.8); 7.7209 (0.8); 7.7163 (2.4); 7.7132 (1.4); 7.7090 (1.8); 7.7050 (1.1); 7.5691 (1.1); 7.3761 (1.0); 7.2614 (24.0); 5.6522 (0.6); 4.5546 (1.2); 4.5428 (1.3); 4.5305 (1.3); 3.8893 (1.4); 3.8772 (1.5); 3.8651 (1.3); 3.7412 (1.4); 3.7332 (1.2); 3.7302 (1.8); 3.7254 (1.3); 3.7182 (2.1); 3.6078 (2.1); 3.6007 (1.3); 3.5958 (1.7); 3.5930 (1.3); 3.5847 (1.4); 3.4052 (14.6); 2.8038 (0.8); 1.5674 (16.0); 1.4132 (3.7); 1.3965 (3.7); 0.0080 (0.9); -0.0002 (27.1); -0.0085 (0.7) I.1-438: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6535 (0.8); 8.6474 (1.0); 8.6043 (0.9); 8.5982 (0.7); 8.2556 (1.0); 8.2343 (1.1); 7.7482 (1.0); 7.7270 (1.0); 7.6996 (0.7); 7.3759 (0.6); 7.3739 (0.6); 7.2612 (18.2); 5.4369 (1.8); 2.8038 (4.7); 1.5667 (16.0); 1.4115 (1.6); 1.3948 (1.6); 0.0079 (0.7); -0.0002 (21.0); -0.0085 (0.6) I.1-439: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.1769 (1.4); 9.1544 (1.4); 8.6950 (2.7); 8.6868 (4.4); 8.6654 (4.7); 8.6573 (2.9); 7.9361 (2.4); 7.9322 (2.1); 7.9246 (2.2); 7.9181 (0.9); 7.8967 (2.3); 7.8901 (1.8); 7.8010 (3.5); 7.7733 (2.3); 7.7534 (3.1); 7.7271 (3.5); 7.4555 (3.0); 7.4514 (3.1); 7.2906 (1.9); 7.2860 (1.8); 7.2643 (1.7); 7.2597 (1.7); 5.4338 (0.8); 5.4111 (1.3); 5.3884 (0.8); 3.8511 (15.3); 3.8147 (16.0); 3.3245 (19.7); 2.5158 (6.7); 2.5099 (13.0); 2.5040 (17.2); 2.4980 (11.8); 2.4924 (5.4); 1.4657 (5.0); 1.4428 (5.0); 0.0108 (0.4); -0.0002 (9.5) BCS241005-Ausland STR 187 I.1-440: 1H-NMR(300.1 MHz, d6-DMSO): δ= 12.7371 (0.3); 9.2147 (1.6); 9.1923 (1.6); 8.6895 (2.7); 8.6813 (5.0); 8.6639 (5.1); 8.6559 (3.0); 7.9609 (2.7); 7.9439 (2.0); 7.9375 (1.1); 7.9159 (2.3); 7.9095 (2.0); 7.8099 (4.0); 7.7821 (2.8); 7.7568 (3.2); 7.7306 (3.6); 7.4363 (3.4); 7.4330 (3.5); 7.2885 (2.0); 7.2844 (2.0); 7.2624 (1.8); 7.2582 (1.8); 5.4289 (0.9); 5.4063 (1.4); 5.3835 (0.9); 3.8505 (16.0); 3.3424 (9.5); 2.5107 (7.6); 2.5049 (10.1); 2.4992 (7.2); 1.4637 (5.4); 1.4408 (5.4); -0.0002 (4.7) I.1-441: 1H-NMR(400.1 MHz, d6-DMSO): δ= 9.1301 (1.8); 9.1132 (1.8); 8.6936 (2.8); 8.6876 (4.0); 8.6649 (4.1); 8.6589 (2.8); 8.1023 (3.3); 8.0974 (3.4); 7.8877 (1.6); 7.8827 (1.5); 7.8663 (1.9); 7.8612 (1.8); 7.7575 (3.0); 7.7378 (3.3); 7.6478 (1.7); 7.6278 (1.5); 7.4602 (3.8); 7.2867 (2.2); 7.2671 (2.0); 5.4134 (1.0); 5.3964 (1.6); 5.3792 (1.0); 4.1293 (0.4); 4.1162 (1.0); 4.1030 (1.1); 4.0899 (0.4); 3.8500 (15.9); 3.8152 (16.0); 3.5089 (0.7); 3.3399 (41.0); 3.3163 (0.4); 3.1761 (4.2); 3.1630 (4.1); 2.5045 (27.6); 1.4545 (6.0); 1.4374 (5.9); -0.0002 (2.7) I.1-442: 1H-NMR(300.1 MHz, d6-DMSO): δ= 12.7694 (0.3); 9.1591 (1.6); 9.1368 (1.6); 8.6881 (2.9); 8.6799 (5.2); 8.6628 (5.4); 8.6547 (3.1); 8.1347 (3.6); 8.1277 (3.8); 7.9122 (1.7); 7.9051 (1.6); 7.8835 (2.1); 7.8764 (2.0); 7.7616 (3.3); 7.7355 (3.7); 7.6599 (1.6); 7.6552 (1.7); 7.6312 (1.4); 7.6266 (1.4); 7.4460 (3.3); 7.4420 (3.4); 7.2879 (2.0); 7.2834 (1.9); 7.2618 (1.8); 7.2572 (1.8); 5.4180 (0.9); 5.3952 (1.4); 5.3725 (0.9); 3.8532 (16.0); 3.3418 (3.1); 2.5172 (3.1); 2.5114 (6.1); 2.5055 (8.1); 2.4996 (5.6); 1.4555 (5.3); 1.4327 (5.2); -0.0002 (3.8) I.1-443: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6625 (0.9); 8.6565 (1.2); 8.6153 (1.0); 8.6092 (0.8); 8.2975 (1.1); 8.2762 (1.3); 7.7717 (1.2); 7.7504 (1.2); 7.7076 (0.8); 7.7032 (0.9); 7.6992 (0.6); 7.5791 (0.5); 7.5666 (0.8); 7.5620 (0.5); 7.5581 (0.7); 7.2615 (15.0); 5.7851 (1.3); 5.7793 (1.2); 2.8038 (15.9); 1.5692 (16.0); 1.4240 (1.8); 1.4073 (1.8); 0.0080 (0.5); -0.0002 (18.5) I.1-444: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6760 (2.2); 8.6699 (2.9); 8.6329 (2.8); 8.6269 (2.1); 8.2208 (3.2); 8.2161 (1.0); 8.2042 (1.2); 8.1996 (3.5); 8.0023 (1.6); 7.9986 (2.9); 7.9949 (1.6); 7.8423 (1.5); 7.8380 (2.4); 7.8338 (1.5); 7.7398 (1.8); 7.7354 (3.0); 7.7309 (4.8); 7.7261 (1.2); 7.7141 (1.1); 7.7095 (3.2); 7.4105 (0.6); 7.3905 (0.6); 7.2609 (40.7); 6.0835 (0.6); 6.0673 (0.9); 6.0480 (0.6); 5.9437 (0.7); 5.9280 (0.5); 5.9183 (0.7); 5.9013 (0.9); 5.8853 (0.6); 5.8755 (0.8); 5.8599 (0.6); 5.2276 (1.4); 5.2019 (1.3); 5.0177 (1.2); 4.9739 (1.1); 3.9744 (16.0); 1.5618 (3.6); 0.0079 (1.4); -0.0002 (46.0); -0.0085 (1.4) I.1-445: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6762 (2.0); 8.6701 (2.6); 8.6326 (2.5); 8.6266 (2.0); 8.2207 (3.1); 8.2160 (1.0); 8.2042 (1.1); 8.1994 (3.6); 8.1953 (0.6); 8.0025 (1.5); 7.9988 (2.9); 7.9951 (1.6); 7.8416 (1.4); 7.8373 (2.4); 7.8332 (1.6); 7.7400 (1.6); 7.7356 (2.9); 7.7312 (4.7); 7.7264 (1.2); 7.7144 (1.0); 7.7098 (3.2); 7.4150 (0.6); 7.3953 (0.6); 7.2613 (20.9); 6.0836 (0.5); 6.0675 (0.8); 6.0643 (0.8); BCS241005-Ausland STR 188 6.0479 (0.6); 5.9441 (0.7); 5.9284 (0.5); 5.9187 (0.7); 5.9017 (1.0); 5.8858 (0.6); 5.8759 (0.8); 5.8603 (0.6); 5.2272 (1.3); 5.2018 (1.3); 5.0166 (1.2); 4.9740 (1.1); 3.9742 (16.0); 1.5744 (1.6); 0.0080 (0.6); - 0.0002 (24.1); -0.0085 (0.7) I.1-446: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.2987 (1.6); 9.2769 (1.6); 8.6962 (2.8); 8.6881 (4.4); 8.6666 (4.4); 8.6586 (2.9); 8.3157 (3.9); 8.0906 (4.0); 8.0857 (3.8); 8.0803 (3.9); 8.0747 (4.7); 8.0687 (5.6); 8.0410 (5.0); 7.7930 (4.8); 7.7655 (4.0); 5.3621 (0.9); 5.3400 (1.5); 5.3172 (1.0); 3.3261 (8.6); 2.7288 (0.4); 2.6058 (16.0); 2.5083 (38.9); 2.5026 (51.0); 2.4971 (37.5); 1.5004 (5.5); 1.4775 (5.5); 1.2332 (0.7); 0.0105 (1.2); -0.0002 (24.9) I.1-447: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.2871 (1.5); 9.2653 (1.5); 8.7068 (2.8); 8.6987 (4.3); 8.6722 (4.5); 8.6641 (3.0); 8.3041 (2.1); 8.2993 (3.8); 8.2945 (2.3); 8.0911 (2.0); 8.0844 (4.3); 8.0803 (6.1); 8.0529 (8.2); 8.0468 (2.7); 7.8163 (4.8); 7.7885 (4.0); 5.3575 (0.9); 5.3350 (1.4); 5.3126 (0.9); 3.8830 (15.6); 3.3317 (15.1); 2.6073 (16.0); 2.5157 (7.6); 2.5102 (15.2); 2.5043 (20.3); 2.4984 (14.9); 1.5065 (5.2); 1.4835 (5.2); 0.0107 (0.6); -0.0002 (16.2); -0.0112 (0.7) I.1-448: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.2057 (4.6); 9.1842 (4.8); 8.7083 (7.9); 8.7003 (11.6); 8.6712 (11.7); 8.6632 (8.3); 7.9385 (8.3); 7.9274 (6.9); 7.9067 (8.1); 7.8992 (7.4); 7.8930 (6.0); 7.8805 (9.8); 7.8174 (10.4); 7.8130 (11.3); 7.8007 (10.6); 7.7729 (6.8); 7.7291 (6.0); 7.7245 (5.6); 7.7028 (4.5); 7.6979 (4.3); 5.3448 (0.6); 5.3240 (2.7); 5.3013 (4.2); 5.2791 (2.7); 5.2550 (0.6); 3.3320 (9.5); 2.5103 (20.7); 2.5049 (26.6); 2.0773 (0.8); 1.4911 (16.0); 1.4683 (15.9); 1.2315 (0.9); -0.0002 (10.5) I.1-449: 1H-NMR(300.1 MHz, d6-DMSO): δ= 13.5449 (0.8); 9.1630 (4.7); 9.1412 (4.9); 8.7126 (8.8); 8.7045 (13.1); 8.6750 (13.6); 8.6669 (9.8); 8.1209 (10.2); 8.1139 (10.8); 7.9247 (8.3); 7.8983 (13.4); 7.8728 (6.0); 7.8657 (5.9); 7.8302 (10.8); 7.8253 (11.6); 7.7391 (6.5); 7.7339 (5.8); 7.7126 (4.9); 7.7073 (4.7); 7.6521 (4.8); 7.6475 (5.1); 7.6233 (4.1); 7.6189 (4.0); 5.3368 (0.6); 5.3142 (2.8); 5.2919 (4.3); 5.2694 (2.8); 5.2461 (0.6); 3.3449 (1.6); 2.5153 (9.4); 2.5094 (12.6); 2.5035 (9.0); 2.0824 (1.6); 1.4906 (16.0); 1.4677 (15.8); -0.0001 (3.8) I.1-450: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.1218 (1.7); 9.0995 (1.8); 8.7163 (2.9); 8.7087 (4.0); 8.6749 (4.0); 8.6671 (3.1); 8.2138 (0.4); 8.2066 (0.4); 8.1330 (1.2); 8.0830 (3.5); 8.0768 (3.6); 7.9459 (0.3); 7.9271 (2.7); 7.9005 (3.5); 7.8749 (1.6); 7.8689 (1.6); 7.8391 (6.0); 7.7463 (2.2); 7.7196 (1.7); 7.7149 (1.7); 7.6410 (1.9); 7.6143 (1.6); 5.3359 (0.4); 5.3141 (1.0); 5.2918 (1.6); 5.2684 (1.0); 3.9637 (2.1); 3.8930 (16.0); 3.3261 (18.5); 2.5031 (22.1); 1.4879 (6.2); 1.4653 (6.9); 1.4431 (1.1); 1.2326 (0.4); - 0.0002 (6.4) BCS241005-Ausland STR 189 I.1-451: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.1887 (1.7); 9.1672 (1.7); 8.7196 (3.1); 8.7119 (4.0); 8.6780 (4.2); 8.6702 (3.0); 8.6576 (0.4); 7.9238 (4.6); 7.9094 (3.5); 7.8978 (4.0); 7.8809 (2.7); 7.8748 (2.0); 7.8487 (4.0); 7.8443 (3.9); 7.7988 (3.6); 7.7711 (2.2); 7.7487 (2.4); 7.7439 (2.1); 7.7220 (1.8); 7.7172 (1.6); 5.3308 (1.0); 5.3080 (1.5); 5.2854 (1.0); 3.9618 (0.5); 3.8924 (16.0); 3.3337 (18.4); 3.3099 (0.5); 2.5104 (6.9); 2.5049 (8.6); 1.5351 (0.6); 1.4943 (6.0); 1.4716 (6.0); -0.0001 (3.8) I.1-452: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.0812 (1.7); 9.0588 (1.8); 8.6835 (2.6); 8.6754 (4.4); 8.6559 (4.6); 8.6480 (3.0); 8.2169 (0.5); 8.2100 (0.5); 8.1341 (0.7); 8.0763 (3.5); 8.0695 (3.7); 7.9515 (0.3); 7.9294 (2.2); 7.9010 (2.6); 7.8796 (1.7); 7.8726 (1.6); 7.8509 (2.1); 7.8439 (2.0); 7.6395 (1.9); 7.6103 (1.8); 7.5974 (2.3); 7.5729 (6.5); 5.3584 (1.1); 5.3357 (1.6); 5.3129 (1.0); 3.9660 (1.3); 3.8583 (16.0); 3.8194 (0.4); 3.3322 (6.0); 2.5392 (14.1); 2.5120 (11.0); 2.5065 (14.1); 2.5013 (10.4); 1.5307 (0.6); 1.5075 (0.7); 1.4777 (6.2); 1.4549 (6.2); -0.0001 (5.2) I.1-453: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.1464 (1.8); 9.1240 (1.8); 8.6847 (2.7); 8.6771 (4.3); 8.6575 (4.3); 8.6500 (2.7); 7.9131 (5.6); 7.8958 (3.1); 7.8852 (2.7); 7.7964 (3.2); 7.7692 (2.0); 7.5972 (2.4); 7.5737 (6.6); 5.3727 (1.1); 5.3500 (1.7); 5.3273 (1.1); 3.9635 (0.5); 3.8574 (16.0); 3.3335 (4.1); 2.5389 (14.6); 2.5070 (15.8); 1.4817 (6.4); 1.4590 (6.3); -0.0002 (5.9) I.1-454: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6481 (3.2); 8.6422 (3.9); 8.5980 (3.4); 8.5921 (2.9); 8.2401 (3.7); 8.2195 (4.6); 7.7755 (4.6); 7.7549 (4.1); 7.7249 (3.1); 7.5880 (2.4); 7.3828 (2.2); 7.2622 (17.4); 7.2465 (1.4); 7.2249 (1.2); 5.6236 (0.6); 5.6056 (1.2); 5.5864 (1.1); 5.5683 (0.6); 3.9742 (16.0); 1.8026 (0.6); 1.7845 (1.1); 1.7667 (1.4); 1.7433 (1.5); 1.7249 (1.2); 1.7076 (0.6); 0.7523 (3.6); 0.7345 (6.9); 0.7165 (3.8); -0.0003 (21.2) I.1-455: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6481 (2.9); 8.6422 (3.3); 8.5984 (3.3); 8.5925 (2.6); 8.2404 (3.9); 8.2198 (4.3); 7.7758 (4.3); 7.7552 (4.0); 7.7249 (3.1); 7.5880 (2.4); 7.3828 (2.2); 7.2622 (17.4); 7.2465 (1.4); 7.2249 (1.2); 5.6236 (0.6); 5.6056 (1.2); 5.5864 (1.1); 5.5683 (0.6); 3.9742 (16.0); 1.8026 (0.6); 1.7845 (1.1); 1.7667 (1.4); 1.7433 (1.5); 1.7249 (1.2); 1.7076 (0.6); 0.7528 (3.4); 0.7345 (6.9); 0.7159 (3.2); -0.0002 (21.2) I.1-456: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6444 (2.7); 8.6384 (3.3); 8.5992 (3.2); 8.5933 (2.5); 8.2398 (3.7); 8.2191 (4.1); 7.8720 (2.0); 7.8684 (3.1); 7.8648 (1.8); 7.7732 (4.1); 7.7526 (3.8); 7.6282 (2.0); 7.5355 (1.9); 7.2622 (18.5); 7.2088 (1.0); 7.1878 (1.0); 5.6038 (1.0); 5.5849 (1.0); 5.5669 (0.5); 3.9741 (16.0); 1.7828 (0.9); 1.7644 (1.1); 1.7589 (1.0); 1.7480 (0.9); 1.7405 (1.3); 1.7223 (1.0); 1.7057 (0.5); 1.5702 (1.6); 0.7508 (3.1); 0.7322 (6.6); 0.7137 (3.0); -0.0002 (22.7); -0.0083 (1.3) BCS241005-Ausland STR 190 I.1-457: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6421 (2.9); 8.6375 (3.4); 8.5979 (3.5); 8.5930 (2.7); 8.2384 (4.3); 8.2185 (4.7); 7.8676 (3.6); 7.7714 (4.7); 7.7515 (4.4); 7.6262 (2.9); 7.5349 (2.8); 7.2620 (17.8); 7.2608 (17.9); 7.2018 (1.4); 7.1818 (1.4); 5.6203 (0.7); 5.6032 (1.4); 5.5838 (1.4); 5.5660 (0.6); 3.9732 (16.0); 1.7982 (0.7); 1.7811 (1.2); 1.7638 (1.6); 1.7389 (1.6); 1.7203 (1.2); 1.7029 (0.7); 1.5670 (4.4); 0.7491 (3.9); 0.7308 (7.5); 0.7124 (3.4); -0.0002 (22.6); -0.0014 (22.1) I.1-458: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6842 (2.7); 8.6783 (3.3); 8.6362 (3.3); 8.6302 (2.6); 8.2244 (3.8); 8.2038 (4.2); 7.7314 (4.2); 7.7105 (5.6); 7.7061 (3.7); 7.5683 (2.2); 7.4810 (1.0); 7.4598 (1.0); 7.3794 (2.0); 7.2618 (34.7); 6.0962 (0.7); 6.0794 (1.3); 6.0604 (0.9); 5.9422 (0.7); 5.9263 (0.6); 5.9168 (0.8); 5.9001 (1.2); 5.8836 (0.7); 5.8741 (0.8); 5.8583 (0.7); 5.2327 (1.9); 5.2074 (1.8); 5.0204 (1.8); 4.9779 (1.6); 3.9767 (16.0); 1.5555 (9.9); -0.0002 (43.1); -0.0080 (2.6) I.1-459: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6877 (2.7); 8.6817 (3.2); 8.6363 (3.2); 8.6303 (2.6); 8.2248 (3.7); 8.2042 (4.1); 7.7335 (4.1); 7.7129 (5.6); 7.7094 (3.8); 7.5706 (2.0); 7.5067 (1.0); 7.4874 (1.0); 7.3780 (1.9); 7.2620 (21.0); 6.0978 (0.7); 6.0812 (1.2); 6.0620 (0.8); 5.9461 (0.7); 5.9304 (0.6); 5.9207 (0.8); 5.9040 (1.2); 5.8876 (0.7); 5.8781 (0.8); 5.8623 (0.7); 5.2348 (1.8); 5.2094 (1.7); 5.0216 (1.7); 4.9795 (1.5); 3.9766 (16.0); -0.0002 (25.8); -0.0082 (1.4) I.1-460: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6556 (2.8); 8.6496 (3.2); 8.6000 (3.2); 8.5940 (2.5); 8.2866 (5.0); 8.2389 (3.8); 8.2180 (4.1); 8.0318 (2.2); 7.8376 (4.1); 7.8168 (3.6); 7.4449 (0.9); 7.4249 (1.0); 7.2630 (12.5); 5.1501 (1.0); 5.1292 (1.8); 5.1081 (1.1); 3.9755 (16.0); 1.5983 (2.0); 1.1848 (0.8); 1.1723 (0.6); 1.1638 (0.7); 0.5488 (0.6); 0.5420 (0.5); 0.5272 (0.8); 0.5227 (0.8); 0.5176 (0.7); 0.3821 (0.6); 0.3764 (0.6); 0.3715 (0.8); 0.3616 (1.6); 0.3509 (1.5); 0.3381 (1.3); 0.3254 (0.7); -0.0002 (13.7); -0.0083 (0.8); -0.0445 (0.6); -0.0560 (0.9); -0.0677 (1.0); -0.0780 (0.5) I.1-461: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6567 (3.0); 8.6508 (3.2); 8.6002 (3.4); 8.5943 (2.6); 8.2869 (5.9); 8.2389 (4.1); 8.2184 (4.4); 8.0317 (2.6); 7.8380 (4.4); 7.8174 (4.0); 7.4502 (1.1); 7.4299 (1.1); 7.2629 (14.5); 5.1489 (1.2); 5.1279 (2.1); 5.1071 (1.2); 3.9755 (16.0); 1.5901 (2.0); 1.1979 (0.5); 1.1853 (0.9); 1.1729 (0.7); 1.1647 (0.9); 1.1519 (0.6); 0.5498 (0.7); 0.5425 (0.6); 0.5277 (0.9); 0.5068 (0.5); 0.3716 (0.9); 0.3620 (1.9); 0.3502 (1.8); 0.3384 (1.5); 0.3248 (0.8); -0.0002 (15.9); -0.0344 (0.6); -0.0451 (0.8); -0.0557 (1.0); -0.0680 (1.1) I.1-462: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6408 (2.8); 8.6350 (3.2); 8.5905 (3.3); 8.5847 (2.6); 8.2280 (4.0); 8.2076 (4.4); 7.8246 (4.4); 7.8041 (4.0); 7.7388 (3.1); 7.5965 (2.4); 7.3869 (2.3); 7.2996 (1.1); 7.2791 (1.3); 7.2629 (10.4); 5.1276 (1.2); 5.1067 (2.2); 5.0859 (1.2); 3.9714 (16.0); 1.5907 (2.9); 1.1456 (0.9); 1.1332 (0.7); 1.1251 (0.9); 1.1128 (0.5); 0.5160 (0.7); 0.5086 (0.6); 0.4899 (0.9); 0.4738 (0.5); BCS241005-Ausland STR 191 0.3576 (0.7); 0.3468 (0.9); 0.3378 (1.8); 0.3268 (1.9); 0.3145 (1.5); 0.3028 (0.8); -0.0002 (11.4); -0.0577 (0.7); -0.0700 (1.0); -0.0819 (1.1) I.1-463: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6482 (2.2); 8.6424 (2.5); 8.5926 (2.6); 8.5868 (2.2); 8.2291 (3.6); 8.2084 (4.1); 7.8297 (4.1); 7.8091 (3.6); 7.7472 (1.9); 7.7435 (2.9); 7.7397 (1.8); 7.6000 (2.1); 7.3857 (2.0); 7.3429 (0.9); 7.3237 (1.0); 7.2629 (11.1); 5.1204 (1.0); 5.0996 (1.8); 5.0787 (1.0); 3.9714 (16.0); 1.1503 (0.8); 1.1375 (0.6); 1.1296 (0.8); 0.5209 (0.6); 0.5141 (0.5); 0.4993 (0.8); 0.4951 (0.8); 0.4901 (0.7); 0.3604 (0.5); 0.3495 (0.8); 0.3397 (1.6); 0.3290 (1.5); 0.3163 (1.3); 0.3038 (0.7); -0.0002 (12.3); -0.0083 (0.8); -0.0587 (0.6); -0.0702 (0.8); -0.0818 (0.9); -0.0923 (0.5) I.1-464: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6426 (1.1); 8.6365 (1.3); 8.5932 (1.3); 8.5871 (1.0); 8.2399 (1.5); 8.2191 (1.6); 7.7729 (1.6); 7.7521 (1.5); 7.4919 (1.4); 7.4866 (1.2); 7.2619 (22.4); 7.2306 (0.5); 3.9745 (6.5); 1.7326 (0.5); 1.5585 (16.0); 0.7483 (1.3); 0.7299 (2.7); 0.7113 (1.2); -0.0002 (24.1); -0.0083 (1.2) I.1-465: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6429 (1.3); 8.6372 (1.6); 8.5931 (1.6); 8.5871 (1.2); 8.2395 (1.9); 8.2192 (2.1); 7.7730 (2.0); 7.7525 (2.0); 7.4917 (1.8); 7.4865 (1.7); 7.4675 (0.8); 7.2618 (42.0); 7.2335 (1.1); 7.2107 (0.8); 7.1298 (0.6); 7.1104 (0.6); 5.6114 (0.6); 5.5943 (0.6); 3.9744 (7.9); 1.7806 (0.5); 1.7618 (0.6); 1.7513 (0.6); 1.7329 (0.7); 1.7151 (0.6); 1.5559 (16.0); 0.7486 (1.7); 0.7301 (3.4); 0.7115 (1.6); 0.0302 (0.5); -0.0002 (45.6); - 0.0081 (2.7) I.1-466: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6398 (1.7); 8.6339 (2.0); 8.5859 (1.9); 8.5799 (1.6); 8.2283 (2.3); 8.2078 (2.6); 7.8241 (2.6); 7.8036 (2.3); 7.5039 (2.1); 7.4993 (2.1); 7.4807 (0.8); 7.3020 (0.7); 7.2801 (0.8); 7.2622 (19.6); 7.1328 (0.7); 7.1121 (0.7); 5.1385 (0.7); 5.1173 (1.3); 5.0966 (0.7); 3.9716 (9.5); 1.5638 (16.0); 1.1404 (0.5); 1.1194 (0.5); 0.4889 (0.5); 0.3253 (1.2); 0.3125 (0.9); -0.0002 (21.5); - 0.0082 (1.3); -0.0723 (0.6); -0.0856 (0.6) I.1-467: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6430 (2.4); 8.6372 (2.8); 8.5872 (3.0); 8.5814 (2.4); 8.2290 (3.8); 8.2083 (4.3); 7.8266 (4.2); 7.8059 (3.8); 7.5060 (3.4); 7.5014 (3.5); 7.4832 (1.4); 7.3187 (1.0); 7.2976 (1.2); 7.2622 (33.7); 7.1341 (1.1); 7.1121 (1.2); 5.1356 (1.1); 5.1148 (2.0); 5.0938 (1.1); 3.9717 (16.0); 1.5694 (3.7); 1.1424 (0.8); 1.1305 (0.7); 1.1221 (0.9); 1.1095 (0.5); 0.5135 (0.6); 0.4908 (0.8); 0.4714 (0.5); 0.3351 (1.4); 0.3264 (2.0); 0.3126 (1.5); 0.3035 (0.7); -0.0002 (37.1); -0.0490 (0.6); -0.0599 (0.7); -0.0715 (1.0); -0.0854 (1.1) BCS241005-Ausland STR 192 I.1-468: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6402 (0.7); 8.6342 (0.9); 8.5911 (0.9); 8.5851 (0.7); 8.2275 (1.0); 8.2069 (1.2); 7.8853 (0.8); 7.8229 (1.1); 7.8023 (1.0); 7.6376 (0.6); 7.5382 (0.6); 7.2617 (16.9); 5.1005 (0.6); 3.9713 (4.3); 1.5567 (16.0); -0.0002 (18.3) I.1-469: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6408 (2.5); 8.6349 (2.9); 8.5914 (3.0); 8.5854 (2.4); 8.2280 (3.8); 8.2074 (4.2); 7.8912 (2.1); 7.8876 (3.1); 7.8839 (1.8); 7.8246 (4.2); 7.8040 (3.7); 7.6404 (2.1); 7.5387 (2.0); 7.2962 (0.9); 7.2630 (15.7); 5.1196 (1.1); 5.0987 (2.0); 5.0779 (1.1); 3.9715 (16.0); 1.5873 (13.1); 1.1478 (0.8); 1.1351 (0.6); 1.1271 (0.8); 0.5187 (0.6); 0.5117 (0.5); 0.4971 (0.8); 0.4929 (0.8); 0.4872 (0.7); 0.3588 (0.5); 0.3482 (0.8); 0.3387 (1.6); 0.3258 (1.5); 0.3146 (1.3); 0.3017 (0.7); -0.0002 (16.9); -0.0081 (1.0); -0.0595 (0.6); -0.0709 (0.9); -0.0825 (1.0); -0.0928 (0.6) I.1-470: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6572 (2.1); 8.6512 (2.5); 8.6077 (2.6); 8.6016 (2.0); 8.2692 (3.7); 8.2514 (3.4); 8.2466 (1.2); 8.2348 (1.4); 8.2301 (3.6); 8.2259 (0.6); 8.0286 (1.6); 7.7852 (3.6); 7.7804 (1.2); 7.7686 (1.3); 7.7639 (3.1); 7.7597 (0.5); 7.3396 (0.7); 7.3189 (0.7); 7.2627 (19.2); 5.6499 (0.8); 5.6314 (0.7); 3.9783 (16.0); 1.8153 (0.9); 1.7990 (1.4); 1.7805 (1.6); 1.7622 (0.9); 1.5820 (6.3); 0.7722 (2.7); 0.7537 (5.7); 0.7351 (2.4); 0.0080 (1.1); -0.0002 (21.8); -0.0085 (0.8) I.1-471: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6578 (2.7); 8.6519 (3.2); 8.6074 (3.2); 8.6015 (2.6); 8.2686 (5.8); 8.2509 (4.1); 8.2303 (4.4); 8.0282 (2.5); 7.7850 (4.3); 7.7644 (4.0); 7.3436 (1.1); 7.3231 (1.2); 7.2622 (28.7); 5.6673 (0.6); 5.6493 (1.2); 5.6300 (1.1); 5.6117 (0.6); 3.9782 (16.0); 1.8345 (0.6); 1.8159 (1.2); 1.7990 (2.0); 1.7813 (2.2); 1.7631 (1.4); 1.7467 (0.6); 1.5694 (8.6); 0.7727 (3.5); 0.7541 (6.9); 0.7355 (3.1); 0.0694 (0.6); -0.0002 (31.7); -0.0083 (1.7) I.1-472: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6675 (2.6); 8.6614 (3.1); 8.6034 (2.7); 8.5973 (2.2); 8.2519 (1.5); 8.2483 (2.7); 8.2447 (1.8); 8.2413 (3.3); 8.2365 (1.0); 8.2247 (1.2); 8.2200 (3.5); 8.2158 (0.5); 7.9881 (1.4); 7.9860 (1.2); 7.9297 (1.3); 7.9277 (1.4); 7.7464 (0.6); 7.7422 (3.5); 7.7375 (1.1); 7.7257 (1.1); 7.7210 (3.2); 7.4850 (0.6); 7.4655 (0.6); 7.2627 (10.0); 5.6958 (0.7); 5.6785 (0.8); 5.6598 (0.6); 4.1308 (1.0); 4.1130 (1.0); 3.9773 (16.0); 3.1289 (15.2); 2.0455 (4.8); 1.6587 (0.6); 1.4440 (5.1); 1.4272 (5.1); 1.2774 (1.4); 1.2596 (2.8); 1.2417 (1.3); 0.9009 (6.2); 0.0079 (0.6); -0.0002 (15.4) I.1-473: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6215 (2.2); 8.6154 (3.0); 8.5883 (2.6); 8.5822 (1.8); 8.2263 (2.8); 8.2215 (0.9); 8.2097 (1.0); 8.2050 (3.3); 7.7812 (0.5); 7.7771 (3.1); 7.7723 (1.0); 7.7605 (0.9); 7.7558 (2.9); 7.4040 (3.1); 7.2617 (5.5); 7.2096 (0.5); 7.1312 (1.4); 5.6922 (0.6); 5.6752 (0.7); 5.6725 (0.7); 5.6555 (0.6); 3.9674 (14.8); 2.3579 (16.0); 2.0448 (1.0); 1.4164 (4.9); 1.3996 (4.9); 1.2591 (0.6); - 0.0002 (8.4) BCS241005-Ausland STR 193 I.1-478: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6497 (2.5); 8.6436 (3.0); 8.5862 (2.6); 8.5801 (2.2); 8.2333 (3.1); 8.2287 (1.0); 8.2168 (1.0); 8.2121 (3.5); 8.2079 (0.5); 7.8096 (1.0); 7.8059 (1.4); 7.8022 (1.1); 7.7468 (0.5); 7.7426 (3.3); 7.7380 (1.1); 7.7261 (1.0); 7.7214 (3.1); 7.6799 (1.1); 7.6749 (1.0); 7.6590 (1.5); 7.6541 (1.5); 7.5647 (2.8); 7.5439 (2.0); 7.3579 (0.5); 7.3382 (0.5); 7.2613 (17.6); 5.6805 (0.6); 5.6632 (0.8); 5.6442 (0.7); 3.9733 (16.0); 1.5725 (7.9); 1.4145 (5.2); 1.3977 (5.2); 0.0080 (0.7); -0.0002 (23.5); -0.0084 (0.7) I.1-479: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6495 (2.6); 8.6434 (3.1); 8.5900 (2.6); 8.5839 (2.2); 8.2331 (3.1); 8.2284 (1.0); 8.2166 (1.1); 8.2118 (3.5); 8.2076 (0.5); 7.9404 (2.4); 7.9350 (2.5); 7.7570 (1.3); 7.7516 (1.3); 7.7449 (0.6); 7.7407 (3.5); 7.7358 (2.5); 7.7302 (1.5); 7.7242 (1.1); 7.7195 (3.1); 7.4046 (1.0); 7.4010 (1.0); 7.3833 (0.9); 7.3797 (0.9); 7.3480 (0.6); 7.3284 (0.6); 7.2621 (9.1); 5.6756 (0.7); 5.6585 (0.8); 5.6565 (0.8); 5.6394 (0.6); 3.9739 (16.0); 2.1720 (0.5); 1.5890 (8.0); 1.4110 (5.2); 1.3943 (5.2); -0.0002 (11.3) I.1-480: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7090 (2.8); 8.7029 (3.2); 8.6282 (3.0); 8.6221 (2.6); 8.3096 (1.6); 8.3059 (3.0); 8.3022 (2.1); 8.2978 (3.3); 8.2932 (1.1); 8.2813 (1.2); 8.2766 (3.8); 8.0231 (1.5); 8.0210 (1.4); 7.9360 (1.5); 7.7926 (3.5); 7.7881 (1.1); 7.7760 (1.2); 7.7715 (3.8); 7.7488 (0.9); 7.2620 (17.7); 5.7410 (0.7); 5.7227 (0.8); 5.7048 (0.7); 3.1551 (0.7); 3.1320 (16.0); 1.5149 (4.7); 1.4981 (4.7); 1.2422 (1.2); 1.2392 (0.6); 0.9008 (0.8); 0.0080 (0.6); -0.0002 (26.8); -0.0085 (0.9) I.1-481: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6583 (2.2); 8.6523 (2.8); 8.6198 (2.6); 8.6137 (1.9); 8.2327 (2.7); 8.2283 (0.9); 8.2162 (1.0); 8.2117 (3.0); 7.7664 (3.0); 7.7619 (0.9); 7.7498 (0.9); 7.7454 (2.7); 7.5261 (0.7); 7.5063 (0.7); 7.4552 (3.2); 7.2611 (9.8); 7.1479 (1.4); 5.7936 (0.6); 5.7765 (0.7); 5.7569 (0.6); 4.1321 (0.6); 4.1143 (0.6); 2.3672 (16.0); 2.0468 (2.8); 1.5099 (4.2); 1.4932 (4.2); 1.2778 (0.8); 1.2600 (1.6); 1.2420 (0.9); 0.9008 (1.9); -0.0002 (14.9); -0.0085 (0.5) I.1-482: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6493 (2.6); 8.6433 (3.1); 8.5857 (2.6); 8.5797 (2.2); 8.2327 (3.2); 8.2280 (1.0); 8.2163 (1.1); 8.2115 (3.4); 8.2073 (0.6); 7.7378 (3.4); 7.7332 (1.1); 7.7213 (1.0); 7.7166 (3.1); 7.7045 (1.1); 7.6992 (1.2); 7.6787 (1.0); 7.6736 (1.2); 7.6302 (0.7); 7.6270 (0.8); 7.6222 (0.6); 7.6090 (0.8); 7.6057 (0.9); 7.6009 (0.7); 7.4026 (0.5); 7.3841 (0.9); 7.3627 (1.0); 7.3428 (0.6); 7.2608 (27.6); 5.6778 (0.7); 5.6586 (0.8); 5.6415 (0.7); 3.9742 (16.0); 1.5543 (13.9); 1.4059 (5.4); 1.3892 (5.3); 0.0080 (1.0); -0.0002 (35.7); -0.0085 (1.1) I.1-483: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6830 (0.5); 8.6769 (0.9); 8.6608 (1.0); 8.6547 (0.6); 8.0613 (0.8); 8.0402 (1.0); 7.9167 (0.8); 7.7954 (0.6); 7.7884 (0.9); 7.7741 (0.5); 7.7673 (0.8); 3.3257 (16.0); 2.5115 (7.0); 2.5070 (15.3); 2.5024 (21.4); 2.4978 (14.9); 2.4932 (6.6); 1.9891 (2.1); 1.4741 (1.0); 1.4569 (1.0); 1.1927 (0.6); 1.1749 (1.2); 1.1572 (0.6); -0.0002 (12.8) BCS241005-Ausland STR 194 I.1-485: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1211 (1.6); 9.1047 (1.6); 8.6866 (3.7); 8.6805 (5.7); 8.6610 (6.3); 8.6549 (4.2); 8.0706 (5.1); 8.0660 (1.6); 8.0542 (1.8); 8.0495 (6.2); 8.0454 (0.9); 7.8886 (0.8); 7.8838 (0.8); 7.8102 (9.7); 7.8054 (13.2); 7.7845 (6.0); 7.7805 (5.2); 7.7758 (4.8); 7.7710 (2.3); 7.7681 (1.8); 7.7634 (5.1); 7.7592 (0.7); 5.3142 (1.1); 5.2974 (1.6); 5.2805 (1.1); 4.0570 (0.6); 4.0392 (1.8); 4.0215 (1.8); 4.0037 (0.6); 3.3305 (16.0); 2.5269 (0.9); 2.5222 (1.3); 2.5134 (16.7); 2.5089 (35.8); 2.5043 (49.3); 2.4997 (33.7); 2.4952 (14.7); 1.9902 (8.2); 1.4696 (6.4); 1.4524 (6.4); 1.3566 (1.3); 1.2325 (0.6); 1.1934 (2.3); 1.1822 (0.7); 1.1757 (4.7); 1.1704 (0.5); 1.1579 (2.3); 0.8879 (3.3); 0.0080 (0.8); - 0.0002 (28.8); -0.0085 (0.8) I.1-486: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6739 (0.8); 8.6592 (0.9); 8.6531 (0.6); 8.0704 (0.7); 8.0492 (0.9); 7.7928 (0.8); 7.7717 (0.8); 4.0382 (0.5); 4.0205 (0.5); 3.3256 (16.0); 2.5113 (6.2); 2.5068 (13.7); 2.5023 (19.1); 2.4977 (13.2); 2.4931 (5.9); 1.9890 (2.5); 1.4676 (0.9); 1.4504 (0.9); 1.1927 (0.7); 1.1749 (1.4); 1.1571 (0.7); -0.0002 (11.9) I.1-487: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6720 (0.9); 8.6660 (1.2); 8.6211 (1.0); 8.6150 (0.8); 8.2199 (1.2); 8.1986 (1.3); 7.9062 (0.9); 7.9011 (0.9); 7.7352 (1.2); 7.7139 (1.2); 7.6347 (0.6); 7.6295 (0.6); 7.5328 (1.1); 7.5121 (0.8); 7.2612 (13.9); 3.9743 (6.0); 1.5592 (16.0); 0.0079 (0.5); -0.0002 (15.7) I.1-488: 1H-NMR(400.6 MHz, CDCl3): δ= 8.5894 (0.7); 8.5833 (0.6); 8.2396 (0.9); 8.2184 (1.0); 8.0014 (2.3); 7.9795 (2.4); 7.9393 (0.6); 7.9342 (0.6); 7.8018 (0.8); 7.7807 (0.7); 7.5310 (0.8); 7.5102 (0.6); 7.2610 (13.6); 7.2461 (1.1); 7.2431 (1.1); 7.2244 (1.1); 7.2212 (1.0); 3.9703 (4.7); 2.8933 (16.0); 2.8392 (1.9); 2.8207 (6.1); 2.8022 (6.2); 2.7838 (2.0); 1.2094 (6.6); 1.1910 (13.4); 1.1725 (6.4); 0.7633 (0.6); 0.7449 (1.4); 0.7264 (0.6); -0.0002 (15.4) I.1-489: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6316 (1.0); 8.6256 (1.3); 8.5837 (1.1); 8.5776 (0.8); 8.2349 (1.2); 8.2137 (1.4); 7.9237 (1.0); 7.9186 (1.0); 7.7773 (1.3); 7.7561 (1.2); 7.6484 (0.6); 7.6432 (0.6); 7.5426 (1.2); 7.5218 (0.8); 7.2611 (14.1); 3.9717 (6.3); 1.5590 (16.0); 0.7437 (1.0); 0.7252 (2.2); 0.7066 (1.0); -0.0002 (16.2) I.1-490: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6290 (0.6); 8.6229 (0.8); 8.5764 (0.6); 8.2236 (0.8); 8.2023 (0.9); 7.9354 (0.6); 7.9302 (0.7); 7.8288 (0.9); 7.8076 (0.8); 7.5470 (0.8); 7.5262 (0.6); 7.2605 (27.0); 3.9690 (4.3); 1.5455 (16.0); 0.0079 (1.0); -0.0002 (31.6); -0.0085 (0.8) I.1-491: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6302 (1.6); 8.6242 (1.9); 8.5767 (1.4); 8.5710 (1.2); 8.2236 (3.0); 8.2189 (1.0); 8.2071 (1.1); 8.2023 (3.6); 8.1982 (0.6); 7.9360 (2.4); 7.9308 (2.5); 7.8298 (3.3); 7.8250 (1.1); 7.8132 (1.0); 7.8085 (3.1); 7.6809 (1.2); 7.6757 (1.1); 7.6601 (1.6); 7.6549 (1.6); 7.5463 BCS241005-Ausland STR 195 (2.9); 7.5255 (2.1); 7.2609 (43.6); 5.1342 (0.8); 5.1134 (1.5); 5.0927 (0.8); 3.9689 (16.0); 2.6182 (0.5); 1.5722 (1.3); 1.2550 (0.8); 1.1384 (0.6); 1.1175 (0.6); 0.4811 (0.5); 0.4759 (0.5); 0.4717 (0.5); 0.3394 (0.6); 0.3350 (0.7); 0.3295 (0.9); 0.3256 (0.6); 0.3201 (1.3); 0.3096 (0.9); 0.3061 (1.0); 0.0080 (1.6); - 0.0002 (51.1); -0.0085 (1.5); -0.0658 (0.5); -0.0803 (0.6) I.1-493: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6498 (2.1); 8.6437 (2.5); 8.5854 (2.1); 8.5793 (1.8); 8.2545 (2.4); 8.2498 (0.8); 8.2380 (0.8); 8.2332 (2.8); 7.8134 (0.8); 7.8096 (1.2); 7.8059 (0.9); 7.7445 (2.6); 7.7399 (0.8); 7.7279 (0.8); 7.7233 (2.5); 7.6824 (0.9); 7.6774 (0.8); 7.6615 (1.3); 7.6565 (1.2); 7.5651 (2.3); 7.5443 (1.6); 7.3491 (0.5); 7.2636 (8.0); 5.6820 (0.5); 5.6631 (0.6); 5.6458 (0.5); 4.5538 (1.3); 4.5419 (1.4); 4.5389 (1.1); 4.5297 (1.5); 3.8887 (1.6); 3.8765 (1.7); 3.8645 (1.5); 3.7411 (1.6); 3.7330 (1.4); 3.7300 (1.9); 3.7252 (1.4); 3.7180 (2.3); 3.6078 (2.3); 3.6007 (1.4); 3.5957 (1.9); 3.5929 (1.4); 3.5846 (1.5); 3.4047 (16.0); 1.6156 (6.4); 1.4123 (4.0); 1.3955 (4.0); -0.0002 (9.8) I.1-494: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6504 (2.1); 8.6444 (2.6); 8.5897 (2.2); 8.5837 (1.8); 8.2543 (2.6); 8.2497 (0.8); 8.2378 (0.9); 8.2331 (2.9); 7.9425 (2.0); 7.9372 (2.1); 7.7587 (1.1); 7.7533 (1.0); 7.7415 (2.9); 7.7373 (2.0); 7.7319 (1.3); 7.7250 (0.9); 7.7204 (2.6); 7.4059 (0.8); 7.4023 (0.8); 7.3845 (0.7); 7.3809 (0.7); 7.3506 (0.6); 7.3312 (0.6); 7.2628 (10.4); 5.6774 (0.6); 5.6585 (0.6); 5.6411 (0.6); 4.5549 (1.4); 4.5430 (1.5); 4.5399 (1.2); 4.5307 (1.5); 3.8896 (1.6); 3.8774 (1.8); 3.8654 (1.5); 3.7416 (1.6); 3.7335 (1.4); 3.7306 (2.0); 3.7257 (1.4); 3.7185 (2.4); 3.6081 (2.4); 3.6010 (1.4); 3.5961 (1.9); 3.5933 (1.4); 3.5850 (1.6); 3.4052 (16.0); 1.5937 (8.2); 1.4084 (4.2); 1.3917 (4.2); -0.0002 (12.7) I.1-495: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6514 (2.1); 8.6453 (2.6); 8.6019 (2.2); 8.5959 (1.8); 8.2524 (2.6); 8.2478 (0.8); 8.2359 (0.9); 8.2312 (2.8); 7.7366 (2.8); 7.7319 (0.8); 7.7200 (0.9); 7.7154 (2.5); 7.6742 (4.8); 7.6695 (5.0); 7.4990 (1.3); 7.4943 (2.4); 7.4896 (1.2); 7.2626 (10.4); 5.6618 (0.5); 5.6448 (0.6); 5.6254 (0.5); 4.5543 (1.3); 4.5425 (1.5); 4.5392 (1.1); 4.5301 (1.5); 3.8893 (1.6); 3.8771 (1.7); 3.8651 (1.5); 3.7416 (1.6); 3.7334 (1.4); 3.7305 (2.0); 3.7256 (1.4); 3.7185 (2.4); 3.6080 (2.4); 3.6008 (1.4); 3.5960 (1.9); 3.5931 (1.4); 3.5849 (1.6); 3.4052 (16.0); 1.5872 (6.2); 1.4071 (4.1); 1.3904 (4.1); - 0.0002 (13.5) I.1-496: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6489 (1.7); 8.6429 (2.1); 8.5875 (1.8); 8.5814 (1.5); 8.2538 (2.0); 8.2492 (0.7); 8.2373 (0.7); 8.2326 (2.4); 7.7518 (0.5); 7.7438 (2.3); 7.7357 (0.6); 7.7302 (0.6); 7.7273 (0.8); 7.7227 (2.2); 7.2992 (0.9); 7.2763 (1.1); 7.2615 (20.7); 7.2544 (0.8); 5.6628 (0.5); 4.5537 (1.1); 4.5418 (1.2); 4.5387 (1.0); 4.5296 (1.2); 3.8886 (1.3); 3.8764 (1.4); 3.8644 (1.2); 3.7410 (1.3); 3.7328 (1.1); 3.7298 (1.6); 3.7250 (1.2); 3.7178 (2.0); 3.6076 (1.9); 3.6004 (1.1); 3.5956 (1.6); 3.5927 (1.2); 3.5845 (1.3); 3.4049 (13.2); 1.5690 (9.6); 1.5668 (16.0); 1.4108 (3.4); 1.3941 (3.4); 0.0079 (0.7); - 0.0002 (25.9); -0.0085 (0.7) BCS241005-Ausland STR 196 I.1-497: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6503 (0.9); 8.6442 (1.1); 8.5847 (1.0); 8.5787 (0.8); 8.2536 (1.1); 8.2324 (1.3); 7.7383 (1.2); 7.7173 (1.2); 7.2612 (17.1); 4.5546 (0.6); 4.5426 (0.7); 4.5304 (0.7); 3.8893 (0.7); 3.8770 (0.8); 3.8650 (0.7); 3.7412 (0.7); 3.7332 (0.6); 3.7301 (0.9); 3.7254 (0.6); 3.7181 (1.0); 3.6078 (1.0); 3.6007 (0.6); 3.5957 (0.8); 3.5930 (0.6); 3.5846 (0.7); 3.4052 (7.0); 1.5581 (16.0); 1.4035 (1.8); 1.3868 (1.8); 0.0080 (0.6); -0.0002 (21.1); -0.0084 (0.6) I.1-498: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6312 (2.4); 8.6252 (3.3); 8.5899 (2.8); 8.5839 (2.1); 8.2262 (3.0); 8.2215 (1.0); 8.2097 (1.0); 8.2049 (3.4); 8.2007 (0.6); 7.8364 (2.3); 7.8309 (2.6); 7.7609 (0.6); 7.7568 (3.3); 7.7520 (1.2); 7.7483 (1.4); 7.7426 (1.3); 7.7405 (1.2); 7.7356 (3.1); 7.7313 (0.6); 7.7269 (1.3); 7.7213 (1.2); 7.2629 (8.4); 7.2252 (0.6); 7.2060 (0.6); 6.9695 (2.0); 6.9479 (1.9); 5.6753 (0.6); 5.6582 (0.7); 5.6559 (0.7); 5.6389 (0.6); 3.9693 (16.0); 3.9511 (14.4); 2.0454 (1.0); 1.6093 (2.4); 1.4070 (5.1); 1.3902 (5.1); 1.2772 (0.5); 1.2638 (0.9); 1.2595 (1.2); 0.9007 (1.0); 0.8818 (1.5); 0.8640 (0.6); - 0.0002 (11.1) I.1-499: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6358 (2.5); 8.6297 (3.1); 8.5817 (2.7); 8.5756 (2.2); 8.2324 (3.2); 8.2279 (1.1); 8.2160 (1.1); 8.2112 (3.7); 7.7670 (0.6); 7.7627 (3.6); 7.7581 (1.2); 7.7462 (1.1); 7.7416 (3.4); 7.7374 (0.5); 7.4806 (2.2); 7.4759 (2.3); 7.4234 (2.1); 7.4031 (2.7); 7.3234 (0.6); 7.3034 (0.6); 7.2659 (1.9); 7.2635 (7.4); 7.2457 (1.2); 7.2409 (1.2); 5.6881 (0.7); 5.6691 (0.8); 5.6518 (0.7); 3.9711 (16.0); 3.9528 (13.9); 2.0452 (0.8); 1.6266 (1.2); 1.4162 (5.5); 1.3994 (5.4); -0.0002 (5.4) I.1-500: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9686 (1.3); 8.9521 (1.3); 8.6737 (2.6); 8.6676 (4.2); 8.6499 (4.7); 8.6438 (3.1); 8.0682 (3.5); 8.0471 (4.3); 7.8005 (3.5); 7.7796 (3.0); 7.4950 (2.4); 7.4900 (3.3); 7.4686 (4.6); 7.4523 (2.7); 7.4479 (2.1); 7.4318 (0.9); 7.4274 (0.8); 5.3347 (0.8); 5.3176 (1.2); 5.3007 (0.8); 3.8892 (16.0); 3.3205 (15.9); 2.6747 (0.8); 2.6700 (1.2); 2.6655 (0.8); 2.5239 (3.8); 2.5191 (5.3); 2.5103 (68.2); 2.5058 (144.1); 2.5013 (197.9); 2.4967 (135.7); 2.4921 (59.3); 2.3328 (0.8); 2.3284 (1.2); 2.3237 (0.8); 1.4665 (4.7); 1.4492 (4.7); 0.1457 (0.6); 0.0281 (0.6); 0.0080 (5.7); -0.0002 (178.9); - 0.0085 (4.7); -0.1493 (0.6) I.1-501: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8524 (1.1); 8.8361 (1.2); 8.6693 (2.1); 8.6633 (3.1); 8.6430 (3.3); 8.6369 (2.2); 8.0735 (3.0); 8.0527 (3.6); 7.9476 (2.4); 7.9422 (2.5); 7.8154 (1.4); 7.8066 (3.7); 7.7938 (1.6); 7.7860 (3.2); 7.1876 (2.1); 7.1657 (1.9); 5.2993 (0.7); 5.2826 (1.1); 5.2657 (0.7); 3.8972 (11.8); 3.3247 (16.0); 2.5246 (1.3); 2.5110 (23.0); 2.5067 (46.1); 2.5023 (61.2); 2.4978 (43.5); 2.4935 (20.3); 1.4454 (4.0); 1.4282 (4.0); 0.0079 (1.6); -0.0002 (39.0); -0.0084 (1.5) I.1-513: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6494 (1.2); 8.6437 (1.4); 8.5887 (1.6); 8.5828 (1.3); 8.2331 (3.1); 8.2287 (1.0); 8.2166 (1.0); 8.2121 (3.4); 7.8254 (0.7); 7.8073 (0.7); 7.7629 (0.6); 7.7573 (0.6); 7.7520 (0.8); 7.7441 (3.5); 7.7360 (0.8); 7.7303 (0.9); 7.7233 (3.2); 7.3331 (0.6); 7.3136 (0.6); 7.2979 BCS241005-Ausland STR 197 (1.3); 7.2752 (1.7); 7.2616 (15.4); 7.2531 (1.2); 5.6785 (0.7); 5.6612 (0.8); 5.6423 (0.7); 5.3002 (10.5); 3.9732 (16.0); 1.5789 (1.9); 1.4144 (5.5); 1.3976 (5.5); 0.0080 (0.6); -0.0002 (19.1) I.1-514: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6443 (1.1); 8.5888 (1.4); 8.5832 (1.2); 8.2331 (3.1); 8.2288 (1.0); 8.2165 (1.1); 8.2121 (3.4); 7.8257 (0.8); 7.8077 (0.8); 7.7633 (0.7); 7.7578 (0.6); 7.7525 (0.8); 7.7443 (3.6); 7.7365 (0.9); 7.7309 (1.0); 7.7235 (3.2); 7.3341 (0.6); 7.3139 (0.6); 7.2980 (1.3); 7.2753 (1.7); 7.2619 (12.9); 7.2531 (1.2); 5.6784 (0.7); 5.6613 (0.8); 5.6423 (0.7); 5.3002 (10.3); 3.9732 (16.0); 1.5934 (1.5); 1.4146 (5.6); 1.3979 (5.5); -0.0002 (15.8) I.1-515: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6813 (0.5); 8.6752 (0.9); 8.6585 (1.0); 8.6524 (0.6); 8.0623 (0.7); 8.0412 (1.0); 7.7916 (0.8); 7.7705 (0.8); 5.7569 (4.0); 3.3234 (16.0); 2.5200 (0.5); 2.5112 (7.4); 2.5066 (16.2); 2.5021 (22.5); 2.4975 (15.6); 2.4929 (6.9); 1.4718 (1.0); 1.4546 (1.0); 1.3554 (0.6); 1.1810 (0.5); 0.8892 (0.6); 0.0080 (0.5); -0.0002 (18.3) I.1-516: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0955 (0.8); 9.0791 (0.8); 8.6814 (1.8); 8.6753 (2.9); 8.6585 (3.3); 8.6524 (2.1); 8.0622 (2.6); 8.0575 (0.8); 8.0456 (0.9); 8.0409 (3.2); 7.9858 (0.6); 7.9667 (1.1); 7.9614 (0.6); 7.9549 (0.7); 7.9449 (0.6); 7.9334 (0.6); 7.7914 (2.8); 7.7867 (0.9); 7.7749 (0.8); 7.7702 (2.6); 7.6134 (0.9); 7.5916 (0.9); 7.5881 (1.0); 7.5665 (0.8); 5.7573 (6.3); 5.3307 (0.5); 5.3136 (0.8); 5.2969 (0.5); 3.3209 (16.0); 2.5245 (0.9); 2.5199 (1.4); 2.5111 (24.9); 2.5066 (54.2); 2.5020 (75.3); 2.4974 (51.8); 2.4928 (23.0); 1.9936 (1.3); 1.9890 (1.3); 1.9091 (1.4); 1.4718 (3.2); 1.4546 (3.2); 1.3555 (1.5); 1.1811 (1.6); 1.1748 (0.9); 0.8892 (1.5); 0.8849 (0.6); 0.0079 (1.8); -0.0002 (63.4); -0.0060 (0.6); - 0.0069 (0.5); -0.0085 (1.7) I.1-517: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7599 (2.6); 8.6492 (6.6); 8.6432 (8.9); 8.6267 (2.1); 8.6045 (7.1); 8.5984 (5.5); 8.2527 (7.8); 8.2481 (2.6); 8.2361 (2.7); 8.2315 (8.7); 8.2275 (1.4); 7.9173 (1.3); 7.9125 (1.4); 7.8535 (1.8); 7.8337 (1.9); 7.7479 (8.3); 7.7433 (2.6); 7.7313 (2.6); 7.7268 (7.8); 7.6871 (1.0); 7.6824 (1.0); 7.6643 (15.2); 7.6596 (16.0); 7.5605 (0.7); 7.5231 (0.5); 7.4956 (4.2); 7.4909 (7.5); 7.4862 (3.7); 7.3882 (1.4); 7.3759 (1.5); 7.3689 (1.5); 7.3569 (1.4); 7.2908 (1.7); 7.2718 (1.7); 7.2620 (49.0); 5.6444 (1.7); 5.6273 (2.0); 5.6081 (1.6); 5.4402 (12.6); 5.3871 (1.2); 5.3001 (10.5); 2.1161 (0.5); 2.0456 (1.0); 1.6741 (3.8); 1.4060 (13.0); 1.3893 (12.9); 1.3332 (0.8); 1.2845 (1.1); 1.2773 (0.7); 1.2594 (2.3); 1.2554 (2.6); 1.2419 (0.6); 0.8816 (0.7); 0.0080 (1.8); -0.0002 (58.9); -0.0085 (1.7) I.1-518: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6507 (2.5); 8.6446 (3.2); 8.6030 (2.7); 8.5970 (2.1); 8.2316 (3.2); 8.2269 (1.0); 8.2151 (1.1); 8.2103 (3.4); 7.8203 (1.5); 7.8163 (2.7); 7.8122 (1.6); 7.7351 (3.4); 7.7304 (1.1); 7.7171 (2.3); 7.7136 (5.0); 7.7089 (1.9); 7.6515 (1.7); 7.6470 (2.8); 7.6424 (1.4); 7.2970 (0.5); 7.2772 (0.6); 7.2611 (29.7); 5.6569 (0.7); 5.6398 (0.8); 5.6206 (0.7); 3.9735 (16.0); 1.5618 (11.3); 1.4098 (5.3); 1.3931 (5.3); 0.0080 (1.1); -0.0002 (35.7); -0.0085 (1.0) BCS241005-Ausland STR 198 I.1-519: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6519 (2.4); 8.6459 (3.4); 8.6169 (2.8); 8.6109 (2.0); 8.1524 (2.2); 8.1323 (2.4); 7.8978 (2.4); 7.8927 (2.5); 7.7614 (1.4); 7.7573 (1.4); 7.7413 (1.2); 7.7372 (1.3); 7.6612 (1.2); 7.6580 (1.7); 7.6547 (1.2); 7.6415 (1.2); 7.6363 (1.1); 7.6207 (1.6); 7.6155 (1.6); 7.5313 (2.9); 7.5105 (2.0); 7.2613 (17.9); 7.2128 (0.5); 7.1931 (0.6); 5.6181 (0.7); 5.6008 (0.8); 5.5818 (0.7); 3.9834 (16.0); 1.5652 (9.2); 1.4466 (5.2); 1.4298 (5.1); 0.0079 (0.7); -0.0002 (22.0); -0.0085 (0.6) I.1-520: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6468 (2.4); 8.6428 (3.0); 8.6121 (2.5); 8.6081 (2.0); 8.1452 (2.1); 8.1319 (2.2); 8.0454 (2.3); 8.0420 (2.3); 7.7548 (1.2); 7.7521 (1.3); 7.7415 (1.2); 7.7388 (1.2); 7.6993 (2.0); 7.6855 (2.6); 7.6551 (1.6); 7.5859 (1.4); 7.5824 (1.4); 7.5721 (1.1); 7.5686 (1.1); 7.2654 (0.7); 7.2594 (36.8); 7.1865 (0.5); 7.1734 (0.5); 5.6062 (0.6); 5.5946 (0.8); 5.5820 (0.6); 3.9876 (0.4); 3.9817 (14.3); 1.5423 (27.0); 1.5350 (0.4); 1.4416 (4.7); 1.4304 (4.8); 1.2538 (0.8); 0.0054 (2.0); -0.0001 (50.0); -0.0056 (1.2) I.1-521: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6625 (2.4); 8.6565 (3.4); 8.6289 (3.0); 8.6229 (2.1); 8.1568 (2.3); 8.1367 (2.6); 7.7536 (1.4); 7.7495 (1.5); 7.7335 (1.3); 7.7294 (1.4); 7.7038 (1.5); 7.6998 (2.4); 7.6957 (1.5); 7.6582 (1.3); 7.6551 (1.8); 7.6518 (1.2); 7.5563 (1.5); 7.3773 (1.4); 7.2611 (21.2); 7.2405 (0.6); 7.2210 (0.6); 5.6176 (0.7); 5.6004 (0.8); 5.5815 (0.7); 3.9852 (16.0); 1.5615 (5.7); 1.4541 (5.4); 1.4373 (5.4); 0.0079 (0.9); -0.0002 (26.3); -0.0085 (0.8) I.1-522: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6621 (2.4); 8.6561 (3.4); 8.6296 (2.9); 8.6235 (2.0); 8.1565 (2.2); 8.1364 (2.5); 7.8501 (1.5); 7.8462 (2.6); 7.8423 (1.5); 7.7540 (1.4); 7.7499 (1.4); 7.7339 (1.2); 7.7298 (1.4); 7.6579 (1.2); 7.6547 (1.7); 7.6514 (1.2); 7.5990 (1.4); 7.5968 (1.3); 7.5270 (1.3); 7.2612 (22.0); 7.2298 (0.6); 7.2103 (0.6); 5.6149 (0.7); 5.5978 (0.8); 5.5788 (0.7); 3.9850 (16.0); 1.5621 (1.5); 1.4543 (5.2); 1.4375 (5.2); 0.0079 (0.9); -0.0002 (27.2); -0.0085 (0.7) I.1-523: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6750 (2.0); 8.6689 (2.7); 8.6374 (2.4); 8.6313 (1.7); 8.2407 (2.8); 8.1680 (1.8); 8.1480 (2.1); 8.0210 (1.2); 7.7643 (1.1); 7.7602 (1.2); 7.7442 (1.0); 7.7401 (1.1); 7.6699 (1.0); 7.6666 (1.4); 7.2608 (33.8); 5.6618 (0.6); 5.6431 (0.7); 5.6256 (0.6); 3.9889 (13.2); 1.5538 (16.0); 1.4885 (4.4); 1.4717 (4.3); 0.0080 (1.2); -0.0002 (42.5); -0.0085 (1.2) I.1-524: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6578 (2.4); 8.6518 (3.4); 8.6279 (3.1); 8.6219 (2.1); 8.1542 (2.3); 8.1341 (2.6); 7.7529 (1.4); 7.7488 (1.5); 7.7328 (1.3); 7.7287 (1.4); 7.6646 (6.1); 7.6599 (7.3); 7.5007 (1.6); 7.4960 (2.9); 7.4913 (1.4); 7.2609 (31.0); 7.2092 (0.6); 7.1893 (0.7); 5.6083 (0.7); 5.5908 (0.9); 5.5719 (0.8); 3.9845 (16.0); 1.5563 (7.2); 1.4463 (5.6); 1.4295 (5.6); 0.0079 (1.4); -0.0002 (37.9); - 0.0085 (1.2) BCS241005-Ausland STR 199 I.1-525: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6551 (2.4); 8.6491 (3.5); 8.6226 (2.8); 8.6166 (2.0); 8.0912 (2.2); 8.0712 (2.4); 7.8487 (1.4); 7.8448 (2.5); 7.8409 (1.4); 7.6548 (1.4); 7.6507 (1.5); 7.6348 (1.2); 7.6307 (1.4); 7.5995 (1.3); 7.5973 (1.2); 7.5627 (1.6); 7.5268 (1.2); 7.5208 (0.6); 7.2615 (15.0); 7.2313 (0.6); 7.2112 (0.6); 6.9249 (1.3); 6.7396 (2.2); 6.5547 (1.4); 5.6369 (0.6); 5.6199 (0.7); 5.6174 (0.7); 5.6003 (0.6); 3.9751 (16.0); 1.5791 (1.1); 1.4536 (4.9); 1.4368 (4.9); 1.2645 (1.1); 0.8987 (0.6); 0.8819 (2.1); 0.8642 (0.8); 0.0080 (0.5); -0.0002 (17.9); -0.0085 (0.5) I.1-526: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6538 (2.4); 8.6477 (3.4); 8.6219 (2.9); 8.6158 (2.0); 8.0912 (2.2); 8.0712 (2.4); 7.7019 (1.4); 7.6979 (2.3); 7.6938 (1.5); 7.6532 (1.4); 7.6491 (1.5); 7.6332 (1.3); 7.6291 (1.4); 7.5591 (2.6); 7.3826 (0.7); 7.3802 (1.0); 7.3777 (1.2); 7.3755 (1.2); 7.2614 (16.9); 7.2293 (0.6); 7.2095 (0.6); 6.9255 (1.3); 6.7403 (2.2); 6.5553 (1.4); 5.6395 (0.6); 5.6226 (0.7); 5.6199 (0.7); 5.6028 (0.6); 3.9754 (16.0); 1.5712 (11.7); 1.4522 (5.1); 1.4355 (5.0); 1.2645 (1.2); 0.8987 (0.6); 0.8820 (2.0); 0.8642 (0.8); 0.0079 (0.6); -0.0002 (20.6); -0.0085 (0.6) I.1-527: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6664 (2.4); 8.6604 (3.4); 8.6303 (2.8); 8.6243 (2.1); 8.2397 (3.4); 8.1027 (2.2); 8.0827 (2.4); 8.0207 (1.5); 7.6668 (1.4); 7.6627 (1.5); 7.6468 (1.2); 7.6427 (1.4); 7.5749 (1.7); 7.3523 (0.6); 7.3327 (0.6); 7.2614 (16.0); 6.9222 (1.3); 6.7370 (2.4); 6.5519 (1.4); 5.6832 (0.7); 5.6660 (0.8); 5.6467 (0.7); 3.9787 (16.0); 1.5756 (13.9); 1.4867 (5.2); 1.4699 (5.2); 1.2648 (0.5); 0.8820 (0.9); 0.0079 (0.6); -0.0002 (19.3); -0.0085 (0.5) I.1-528: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6431 (1.8); 8.6371 (2.6); 8.6098 (2.1); 8.6038 (1.5); 8.0862 (1.7); 8.0661 (1.8); 8.0449 (1.9); 8.0398 (1.9); 7.7053 (1.6); 7.6845 (2.2); 7.6583 (1.0); 7.6542 (1.1); 7.6383 (0.9); 7.6342 (1.0); 7.5927 (1.2); 7.5875 (1.2); 7.5720 (0.9); 7.5665 (1.3); 7.5626 (1.3); 7.2613 (18.0); 6.9313 (1.0); 6.7461 (1.6); 6.5610 (1.0); 5.6184 (0.6); 5.6156 (0.5); 3.9734 (12.1); 2.0456 (0.5); 1.5643 (16.0); 1.4436 (3.8); 1.4268 (3.8); 1.2645 (0.7); 1.2599 (0.7); 0.8820 (1.1); 0.0080 (0.7); -0.0002 (22.0); -0.0085 (0.6) I.1-529: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6501 (2.4); 8.6441 (3.5); 8.6212 (3.0); 8.6152 (2.0); 8.0887 (2.3); 8.0687 (2.5); 7.6630 (6.0); 7.6583 (6.2); 7.6518 (1.5); 7.6477 (1.5); 7.6318 (1.3); 7.6277 (1.4); 7.5628 (1.8); 7.5004 (1.6); 7.4958 (2.9); 7.4911 (1.4); 7.2614 (16.4); 7.2017 (0.6); 7.1821 (0.6); 6.9293 (1.3); 6.7442 (2.3); 6.5590 (1.4); 5.6305 (0.7); 5.6135 (0.8); 5.6107 (0.8); 5.5938 (0.7); 3.9748 (16.0); 2.0458 (0.8); 1.5714 (2.0); 1.4447 (5.4); 1.4279 (5.3); 1.2646 (0.9); 1.2599 (1.0); 0.8820 (1.4); 0.8643 (0.6); 0.0079 (0.6); -0.0002 (19.8); -0.0085 (0.6) I.1-530: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6453 (2.4); 8.6393 (3.4); 8.6107 (2.8); 8.6047 (2.0); 8.0869 (2.2); 8.0668 (2.4); 7.8963 (2.4); 7.8912 (2.5); 7.6588 (1.4); 7.6547 (1.5); 7.6426 (1.3); 7.6382 (1.8); 7.6347 (1.5); 7.6218 (1.7); 7.6166 (1.6); 7.5643 (1.7); 7.5319 (2.9); 7.5111 (2.0); 7.2611 (32.8); 7.2081 BCS241005-Ausland STR 200 (0.6); 7.1873 (0.6); 6.9337 (1.3); 6.7485 (2.1); 6.5634 (1.4); 5.6411 (0.6); 5.6241 (0.7); 5.6214 (0.7); 5.6044 (0.6); 3.9738 (16.0); 2.0458 (1.4); 1.5642 (3.8); 1.4455 (5.2); 1.4287 (5.1); 1.2775 (0.9); 1.2645 (1.6); 1.2599 (1.9); 1.2420 (0.6); 0.8988 (0.8); 0.8820 (2.8); 0.8643 (1.1); 0.0080 (1.2); -0.0002 (39.8); - 0.0085 (1.1) I.1-532: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6891 (6.1); 8.6831 (8.5); 8.6557 (7.8); 8.6496 (5.7); 8.2198 (6.0); 8.1998 (6.6); 7.7603 (3.5); 7.7563 (3.7); 7.7402 (3.2); 7.7362 (3.6); 7.6991 (15.4); 7.6944 (16.0); 7.6648 (4.9); 7.5193 (0.8); 7.5140 (4.6); 7.5094 (8.2); 7.5047 (4.1); 7.4230 (1.7); 7.4039 (1.7); 7.2908 (0.8); 7.2609 (119.8); 6.9972 (0.6); 5.6656 (1.7); 5.6476 (2.2); 5.6295 (1.7); 5.6119 (0.5); 5.3003 (6.0); 1.4990 (12.8); 1.4823 (12.9); 0.0296 (0.8); 0.0079 (3.9); -0.0002 (139.1); -0.0085 (4.2); -0.1493 (0.6) I.1-533: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6254 (2.4); 8.6213 (2.9); 8.5824 (2.5); 8.5784 (2.1); 7.9447 (2.2); 7.9315 (2.3); 7.8601 (5.0); 7.8572 (5.6); 7.8014 (1.5); 7.7985 (2.5); 7.7957 (1.2); 7.2961 (1.8); 7.2937 (2.0); 7.2671 (0.5); 7.2603 (28.9); 7.2428 (0.5); 7.2399 (0.4); 7.2377 (0.5); 7.2260 (1.6); 7.2235 (1.4); 7.2128 (1.2); 7.2103 (1.2); 5.7047 (0.6); 5.6918 (0.7); 5.6803 (0.6); 4.2695 (0.5); 4.2578 (0.6); 4.2541 (0.9); 4.2424 (0.8); 4.2002 (0.8); 4.1886 (0.9); 4.1848 (0.6); 4.1732 (0.6); 3.9341 (14.0); 2.0044 (1.2); 1.5768 (0.4); 1.5635 (1.2); 1.5570 (50.0); 1.5343 (0.3); 1.5032 (3.1); 1.4916 (6.5); 1.4800 (3.1); 1.3855 (4.6); 1.3743 (4.6); 0.0054 (0.8); -0.0001 (26.3); -0.0055 (0.9) I.1-534: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6470 (2.6); 8.6410 (3.2); 8.5934 (2.8); 8.5874 (2.3); 8.2505 (3.7); 8.0203 (1.6); 7.9628 (2.4); 7.9431 (2.6); 7.4342 (0.6); 7.4151 (0.6); 7.3049 (2.2); 7.3015 (2.3); 7.2617 (16.2); 7.2460 (1.5); 7.2422 (1.4); 7.2263 (1.4); 7.2225 (1.3); 5.7695 (0.7); 5.7521 (0.8); 5.7331 (0.7); 4.2826 (0.5); 4.2651 (0.6); 4.2595 (1.1); 4.2420 (1.0); 4.2148 (1.0); 4.1974 (1.1); 4.1917 (0.6); 4.1743 (0.6); 3.9401 (16.0); 1.5802 (10.9); 1.5158 (3.4); 1.4984 (7.2); 1.4810 (3.4); 1.4294 (5.3); 1.4126 (5.3); 0.0079 (0.6); -0.0002 (19.6); -0.0085 (0.6) I.1-535: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6251 (2.3); 8.6190 (3.4); 8.5949 (2.9); 8.5888 (2.0); 7.7142 (1.4); 7.7102 (2.3); 7.7061 (1.4); 7.5587 (1.4); 7.3788 (1.2); 7.2611 (27.9); 7.2124 (0.6); 7.1920 (0.6); 7.1737 (2.2); 7.0567 (1.3); 7.0535 (1.2); 7.0336 (1.3); 7.0304 (1.2); 5.7413 (0.6); 5.7241 (0.7); 5.7215 (0.7); 5.7044 (0.6); 3.9786 (16.0); 3.9732 (14.2); 1.5602 (13.2); 1.4123 (4.9); 1.3955 (4.9); 0.0080 (1.0); - 0.0002 (33.8); -0.0085 (0.9) I.1-536: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6251 (2.6); 8.6190 (3.2); 8.5748 (2.8); 8.5688 (2.3); 7.9500 (2.4); 7.9302 (2.6); 7.9071 (2.5); 7.9019 (2.6); 7.6495 (1.2); 7.6443 (1.1); 7.6287 (1.7); 7.6235 (1.6); 7.5329 (3.0); 7.5121 (2.1); 7.2994 (2.2); 7.2959 (2.4); 7.2859 (0.7); 7.2617 (15.6); 7.2385 (1.5); 7.2347 (1.4); 7.2187 (1.4); 7.2149 (1.3); 5.7258 (0.7); 5.7087 (0.8); 5.6893 (0.7); 4.2774 (0.6); 4.2598 (0.6); 4.2542 (1.0); 4.2367 (1.0); 4.2040 (1.0); 4.1866 (1.1); 4.1809 (0.6); 4.1635 (0.6); 3.9347 (16.0); 1.5814 BCS241005-Ausland STR 201 (3.8); 1.5078 (3.5); 1.4904 (7.2); 1.4730 (3.4); 1.3907 (5.3); 1.3740 (5.3); 0.0079 (0.6); -0.0002 (18.4); - 0.0085 (0.5) I.1-537: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2541 (0.5); 9.2500 (0.6); 9.2418 (0.6); 9.2377 (0.6); 8.6984 (1.0); 8.6923 (1.5); 8.6695 (1.7); 8.6635 (1.2); 8.1654 (1.4); 8.1442 (1.6); 7.8837 (0.7); 7.8795 (0.7); 7.8349 (1.5); 7.8136 (1.4); 7.7989 (0.9); 7.7944 (2.3); 7.7896 (3.6); 7.7868 (1.0); 7.7778 (0.6); 7.7729 (1.1); 7.7682 (1.1); 7.7655 (0.7); 7.7636 (0.6); 5.6740 (2.8); 3.3220 (16.0); 2.5250 (0.5); 2.5204 (0.7); 2.5116 (9.0); 2.5070 (19.4); 2.5025 (26.7); 2.4979 (18.3); 2.4933 (8.0); 1.4729 (1.7); 1.4557 (1.7); - 0.0002 (15.6) I.1-538: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1297 (4.2); 9.1132 (4.4); 8.6857 (8.7); 8.6796 (13.5); 8.6611 (14.7); 8.6550 (9.7); 8.0729 (12.4); 8.0685 (4.4); 8.0564 (5.0); 8.0518 (14.8); 8.0196 (0.6); 7.9556 (6.3); 7.9516 (10.7); 7.9477 (7.1); 7.9228 (0.8); 7.9191 (1.1); 7.9148 (0.6); 7.8917 (6.4); 7.8871 (11.9); 7.8826 (6.5); 7.8462 (7.8); 7.8423 (9.5); 7.8379 (5.9); 7.7825 (13.9); 7.7780 (4.6); 7.7659 (4.6); 7.7614 (12.1); 5.3341 (0.6); 5.3171 (2.7); 5.3002 (4.2); 5.2833 (2.8); 5.2663 (0.6); 3.3444 (1.1); 2.5290 (1.3); 2.5243 (2.2); 2.5155 (25.4); 2.5111 (52.6); 2.5065 (71.1); 2.5020 (49.6); 2.4975 (22.4); 1.4686 (16.0); 1.4514 (15.9); 1.2298 (0.8); 0.0080 (1.3); -0.0002 (35.0); -0.0085 (1.1) I.1-543: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6890 (0.7); 8.6647 (0.8); 8.6586 (0.5); 8.1146 (0.6); 8.0933 (0.8); 7.9837 (2.8); 7.7995 (0.7); 7.7783 (0.6); 5.4363 (1.1); 3.3240 (16.0); 2.5118 (4.4); 2.5073 (9.5); 2.5027 (13.1); 2.4982 (8.9); 2.4936 (3.9); 1.4775 (0.8); 1.4602 (0.8); -0.0002 (11.2) I.1-544: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2541 (1.2); 9.2499 (1.2); 9.2418 (1.2); 9.2376 (1.2); 9.1654 (0.9); 9.1490 (0.9); 8.7018 (2.1); 8.6957 (3.1); 8.6727 (3.5); 8.6666 (2.5); 8.1624 (2.9); 8.1578 (0.9); 8.1459 (1.0); 8.1412 (3.4); 8.0051 (12.9); 7.9059 (1.0); 7.9018 (1.0); 7.8848 (1.5); 7.8806 (1.4); 7.8285 (3.2); 7.8238 (1.0); 7.8119 (1.0); 7.8072 (2.9); 7.7978 (1.8); 7.7855 (1.6); 7.7766 (1.2); 7.7643 (1.2); 5.6736 (6.0); 5.3018 (0.6); 5.2850 (0.9); 5.2681 (0.6); 3.3223 (16.0); 2.5256 (0.8); 2.5209 (1.1); 2.5122 (15.5); 2.5077 (33.4); 2.5031 (46.2); 2.4985 (31.7); 2.4940 (13.9); 1.9898 (2.2); 1.4824 (3.5); 1.4652 (3.5); 1.2308 (0.6); 1.1931 (0.7); 1.1753 (1.3); 1.1576 (0.6); 0.0079 (1.2); -0.0002 (39.7); -0.0085 (1.1) I.1-545: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6360 (1.6); 8.6301 (2.0); 8.5859 (2.1); 8.5799 (1.7); 7.9533 (2.4); 7.9336 (2.6); 7.7147 (1.5); 7.7106 (2.6); 7.7067 (1.6); 7.5660 (1.6); 7.3736 (1.6); 7.3283 (0.7); 7.3085 (0.8); 7.2981 (2.3); 7.2949 (2.5); 7.2625 (9.2); 7.2352 (1.4); 7.2316 (1.4); 7.2155 (1.3); 7.2119 (1.3); 5.7254 (0.7); 5.7065 (0.9); 5.6891 (0.7); 4.2783 (0.6); 4.2607 (0.6); 4.2551 (1.0); 4.2376 (1.0); 4.2075 (1.0); 4.1901 (1.1); 4.1844 (0.6); 4.1669 (0.6); 3.9362 (16.0); 1.5102 (3.4); 1.4929 (7.1); 1.4755 (3.4); 1.3982 (5.3); 1.3814 (5.3); -0.0002 (10.4) BCS241005-Ausland STR 202 I.1-546: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6297 (2.5); 8.6236 (3.3); 8.5854 (2.8); 8.5793 (2.2); 7.9515 (2.4); 7.9317 (2.5); 7.6719 (5.9); 7.6672 (6.3); 7.5002 (1.6); 7.4955 (3.0); 7.4907 (1.5); 7.2971 (2.0); 7.2936 (2.2); 7.2611 (31.1); 7.2518 (0.7); 7.2313 (1.6); 7.2274 (1.4); 7.2115 (1.4); 7.2077 (1.3); 5.7173 (0.6); 5.6978 (0.7); 5.6808 (0.6); 4.2785 (0.5); 4.2610 (0.6); 4.2554 (1.0); 4.2378 (1.0); 4.2061 (1.0); 4.1887 (1.0); 4.1831 (0.6); 4.1656 (0.6); 3.9355 (16.0); 1.5605 (6.8); 1.5106 (3.4); 1.4932 (7.2); 1.4758 (3.3); 1.3882 (5.1); 1.3714 (5.1); 0.0079 (0.9); -0.0002 (34.8); -0.0085 (1.0) I.1-547: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6352 (2.6); 8.6292 (3.2); 8.5861 (3.1); 8.5801 (2.5); 7.9531 (2.6); 7.9333 (2.7); 7.8612 (1.8); 7.8578 (3.0); 7.8543 (1.9); 7.6091 (2.0); 7.5249 (2.0); 7.3236 (0.9); 7.2990 (3.2); 7.2961 (3.2); 7.2639 (4.7); 7.2356 (1.6); 7.2322 (1.6); 7.2159 (1.5); 7.2124 (1.5); 5.7230 (0.8); 5.7049 (1.1); 5.6868 (0.8); 4.2778 (0.6); 4.2602 (0.7); 4.2547 (1.2); 4.2372 (1.2); 4.2074 (1.2); 4.1900 (1.2); 4.1844 (0.7); 4.1669 (0.6); 3.9360 (16.0); 1.5100 (3.7); 1.4926 (7.5); 1.4753 (3.6); 1.3983 (6.0); 1.3815 (6.0); -0.0002 (5.4) I.1-548: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6199 (2.2); 8.6138 (3.4); 8.5938 (2.8); 8.5878 (1.8); 7.6708 (5.7); 7.6661 (6.1); 7.5033 (1.6); 7.4986 (2.9); 7.4939 (1.4); 7.2613 (17.7); 7.1796 (2.4); 7.1558 (0.5); 7.0555 (1.3); 7.0523 (1.2); 7.0324 (1.3); 7.0292 (1.2); 5.7354 (0.6); 5.7184 (0.7); 5.7155 (0.7); 5.6984 (0.6); 3.9777 (16.0); 3.9738 (14.1); 1.5650 (9.6); 1.4031 (4.8); 1.3863 (4.8); 0.0080 (0.6); -0.0002 (20.1); -0.0085 (0.6) I.1-549: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6244 (2.4); 8.6184 (3.5); 8.5954 (2.9); 8.5894 (2.0); 7.8599 (1.4); 7.8560 (2.5); 7.8521 (1.5); 7.6011 (1.4); 7.5989 (1.3); 7.5306 (1.3); 7.2614 (19.0); 7.1999 (0.6); 7.1743 (2.4); 7.0569 (1.3); 7.0536 (1.3); 7.0338 (1.3); 7.0305 (1.2); 5.7390 (0.6); 5.7219 (0.7); 5.7191 (0.7); 5.7020 (0.6); 3.9784 (16.0); 3.9728 (14.2); 1.5691 (6.2); 1.4117 (4.9); 1.3948 (4.9); 0.0079 (0.6); - 0.0002 (21.6); -0.0085 (0.6) I.1-550: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6138 (2.4); 8.6078 (3.5); 8.5822 (2.8); 8.5762 (2.0); 8.0553 (2.5); 8.0502 (2.5); 7.7069 (2.1); 7.6862 (3.0); 7.5970 (1.6); 7.5918 (1.6); 7.5763 (1.2); 7.5711 (1.2); 7.2624 (10.7); 7.1810 (2.6); 7.1606 (0.6); 7.0624 (1.3); 7.0591 (1.2); 7.0392 (1.3); 7.0359 (1.2); 5.7365 (0.6); 5.7196 (0.7); 5.7166 (0.7); 5.6995 (0.6); 3.9763 (16.0); 3.9703 (14.0); 2.0079 (1.1); 1.5927 (4.1); 1.4038 (4.8); 1.3870 (4.8); -0.0002 (12.0) I.1-551: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6368 (1.8); 8.6307 (2.4); 8.6012 (2.0); 8.5951 (1.4); 8.2477 (2.3); 8.0239 (1.0); 7.2617 (11.4); 7.1853 (1.5); 7.0701 (0.9); 7.0669 (0.9); 7.0471 (0.9); 7.0438 (0.9); 5.7686 (0.5); 5.7660 (0.5); 3.9822 (16.0); 1.5780 (10.3); 1.4443 (3.4); 1.4274 (3.4); -0.0002 (12.7) BCS241005-Ausland STR 203 I.1-556: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6071 (0.8); 8.6020 (1.9); 8.5964 (1.8); 8.5906 (0.7); 8.2073 (1.6); 8.1870 (1.7); 7.7468 (1.7); 7.7265 (1.6); 7.7011 (0.6); 7.6728 (1.2); 7.6533 (1.0); 7.3841 (1.0); 7.3615 (1.0); 7.2622 (16.0); 4.0244 (0.9); 3.9804 (1.0); 3.9562 (6.2); 3.7770 (6.8); 3.7695 (6.9); 3.3901 (0.9); 3.3460 (0.8); 2.1745 (0.7); 1.6878 (0.5); 1.6731 (5.4); 1.6543 (0.6); 1.6472 (0.7); 1.5606 (16.0); 1.2632 (1.0); 0.8816 (1.1); 0.8636 (0.5); 0.6542 (1.2); 0.6358 (2.6); 0.6174 (1.2); -0.0002 (16.7) I.1-557: 1H-NMR(400.6 MHz, CDCl3): δ= 8.5444 (0.6); 8.5064 (0.6); 8.1916 (0.6); 8.1707 (0.7); 7.7269 (0.7); 7.7062 (0.6); 7.2618 (16.5); 3.9542 (2.6); 3.7739 (3.2); 3.7696 (3.1); 1.7483 (2.0); 1.5553 (16.0); 0.7287 (0.5); 0.7105 (1.1); -0.0002 (17.4); -0.0083 (0.8) I.1-558: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6452 (1.1); 8.6392 (1.3); 8.6063 (1.3); 8.6004 (0.9); 8.4498 (0.9); 8.4300 (0.9); 8.2938 (2.0); 8.2397 (1.4); 8.2190 (1.5); 7.7847 (1.5); 7.7639 (1.4); 7.4761 (0.9); 7.4540 (0.9); 7.2620 (20.6); 3.9731 (5.7); 3.7906 (12.0); 2.1747 (1.3); 1.7649 (0.5); 1.5627 (16.0); 1.2638 (0.9); 0.8819 (1.1); 0.8639 (0.5); 0.7656 (1.1); 0.7470 (2.3); 0.7285 (1.0); -0.0002 (21.6); -0.0084 (1.2) I.1-559: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6406 (1.0); 8.6347 (1.3); 8.6040 (1.2); 8.5980 (0.9); 8.3882 (0.8); 8.3688 (0.9); 8.2842 (2.0); 8.2377 (1.4); 8.2168 (1.5); 7.7837 (1.5); 7.7628 (1.3); 7.4654 (0.9); 7.4432 (0.9); 7.2607 (18.6); 6.3856 (1.7); 3.9716 (5.8); 3.5753 (2.8); 1.7640 (0.5); 1.5540 (16.0); 1.2646 (1.0); 0.8820 (1.2); 0.8643 (0.5); 0.7651 (1.1); 0.7466 (2.4); 0.7281 (1.0); -0.0002 (17.6); -0.0083 (0.9) I.2-1: 1H-NMR (400.6 MHz, d6-DMSO): δ= 8.6960 (0.6); 8.6899 (0.9); 8.6698 (1.1); 8.6637 (0.7); 8.1709 (0.5); 7.9183 (0.6); 7.6570 (0.5); 7.6563 (0.5); 3.8362 (4.2); 3.3236 (16.0); 2.5201 (0.6); 2.5114 (7.1); 2.5069 (15.2); 2.5023 (21.0); 2.4977 (14.4); 2.4931 (6.3); 1.4896 (1.0); 1.4724 (1.0); -0.0002 5 (14.8). I.2-3: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6683 (2.4); 8.6622 (2.9); 8.6095 (2.4); 8.6034 (2.0); 8.3098 (1.0); 8.3058 (1.8); 8.3020 (1.1); 8.2464 (3.0); 8.2172 (0.7); 8.2139 (1.0); 8.2101 (0.7); 8.1977 (0.8); 8.1940 (1.0); 8.1906 (0.7); 8.0157 (1.3); 7.8970 (0.6); 7.8927 (0.8); 7.8896 (0.7); 7.8779 (0.8); 7.8736 10 (1.0); 7.8704 (0.8); 7.6731 (1.0); 7.6539 (1.7); 7.6345 (0.8); 7.2605 (47.4); 5.6849 (0.6); 5.6662 (0.7); 5.6492 (0.6); 3.9529 (16.0); 1.5547 (1.6); 1.4898 (5.0); 1.4731 (5.0); 0.8821 (0.6); 0.0079 (1.7); -0.0002 (58.8); -0.0085 (1.9) I.2-4: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6351 (2.3); 8.6291 (3.0); 8.5895 (2.7); 8.5834 (2.1); 8.3044 15 (1.1); 8.3003 (2.1); 8.2962 (1.2); 8.2017 (0.7); 8.1985 (1.1); 8.1948 (0.8); 8.1822 (0.8); 8.1789 (1.2); 8.1752 (0.8); 7.9179 (0.7); 7.9146 (0.9); 7.9105 (0.7); 7.8988 (0.8); 7.8954 (1.0); 7.8914 (0.8); 7.6916 (0.5); 7.6878 (1.0); 7.6848 (0.9); 7.6766 (1.1); 7.6719 (3.2); 7.6679 (3.3); 7.6598 (1.2); 7.6404 (2.0); 7.6211 (0.9); 7.5541 (0.6); 7.5513 (0.7); 7.5493 (0.6); 7.5465 (0.6); 7.5346 (0.9); 7.5308 (1.3); 7.5269 BCS241005-Ausland STR 204 (0.8); 7.4561 (1.4); 7.4360 (1.6); 7.4158 (0.8); 7.3557 (0.6); 7.3366 (0.6); 7.2617 (12.8); 5.6605 (0.7); 5.6434 (0.8); 5.6241 (0.7); 5.2997 (9.6); 3.9444 (16.0); 3.9282 (0.8); 1.7801 (1.1); 1.7674 (2.7); 1.7610 (2.8); 1.7488 (1.3); 1.5906 (1.1); 1.4817 (0.8); 1.4789 (0.8); 1.4680 (2.9); 1.4609 (7.5); 1.4440 (5.4); 0.0079 (0.6); -0.0002 (16.2); -0.0085 (0.5) 5 I.2-5: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.0766 (0.5); 9.4251 (0.9); 9.4087 (1.0); 8.6947 (2.0); 8.6886 (3.6); 8.6742 (4.0); 8.6680 (2.4); 8.4308 (3.2); 8.2785 (1.4); 8.1844 (1.1); 8.1806 (2.0); 8.1766 (1.2); 8.0305 (0.7); 8.0274 (1.1); 8.0235 (0.7); 8.0111 (0.8); 8.0079 (1.1); 8.0041 (0.8); 7.9509 (0.7); 7.9478 (0.9); 7.9435 (0.6); 7.9318 (0.8); 7.9275 (1.0); 7.9243 (0.7); 7.6541 (1.0); 7.6349 (1.9); 7.6156 10 (0.9); 5.3771 (0.6); 5.3603 (0.9); 5.3432 (0.6); 3.3222 (16.0); 2.5254 (0.8); 2.5207 (1.2); 2.5120 (20.4); 2.5074 (44.2); 2.5029 (61.5); 2.4983 (42.3); 2.4937 (18.5); 1.9895 (1.0); 1.5273 (3.6); 1.5101 (3.6); 1.1753 (0.6); 0.0080 (0.8); -0.0002 (27.7); -0.0086 (0.8) I.2-7: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.0972 (0.5); 9.1827 (1.4); 9.1664 (1.4); 8.6833 (3.0); 15 8.6771 (5.4); 8.6631 (6.0); 8.6570 (3.6); 8.1851 (1.6); 8.1810 (3.0); 8.1772 (1.7); 8.0434 (1.1); 8.0403 (1.6); 8.0363 (1.1); 8.0240 (1.2); 8.0203 (1.6); 8.0169 (1.2); 7.9443 (3.2); 7.9401 (4.4); 7.9363 (3.0); 7.9252 (1.2); 7.9209 (1.5); 7.9178 (1.1); 7.7415 (1.9); 7.7388 (1.5); 7.7366 (1.2); 7.7138 (2.0); 7.7110 (2.1); 7.7084 (1.6); 7.6579 (1.5); 7.6386 (2.7); 7.6191 (1.3); 5.3196 (0.9); 5.3028 (1.4); 5.2859 (0.9); 4.0386 (0.5); 4.0208 (0.5); 3.3223 (16.0); 2.5253 (1.4); 2.5205 (1.8); 2.5118 (27.4); 2.5072 (59.6); 20 2.5026 (83.0); 2.4980 (56.9); 2.4935 (24.8); 1.9894 (2.4); 1.4882 (5.4); 1.4710 (5.4); 1.3560 (0.7); 1.1929 (0.7); 1.1751 (1.4); 1.1573 (0.7); 0.0080 (1.1); -0.0002 (38.5); -0.0085 (1.0) I.2-8: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6664 (2.4); 8.6603 (2.9); 8.6050 (2.6); 8.5989 (2.2); 8.3045 (1.0); 8.3003 (2.0); 8.2965 (1.1); 8.2116 (0.7); 8.2082 (1.0); 8.2046 (0.7); 8.1921 (0.8); 8.1884 (1.1); 25 8.1851 (0.8); 7.9685 (1.7); 7.9645 (1.2); 7.9416 (1.6); 7.9402 (1.6); 7.8988 (0.7); 7.8946 (0.8); 7.8913 (0.7); 7.8796 (0.8); 7.8753 (1.0); 7.8722 (0.8); 7.7407 (1.5); 7.6670 (1.0); 7.6477 (1.8); 7.6283 (0.8); 7.4606 (0.5); 7.4418 (0.6); 7.2617 (9.9); 5.6589 (0.7); 5.6417 (0.8); 5.6228 (0.6); 3.9500 (16.0); 1.4749 (5.2); 1.4582 (5.2); 1.2635 (0.8); 1.2600 (0.8); 0.8818 (1.2); -0.0002 (12.0) 30 I.2-9: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6456 (4.2); 8.5974 (4.2); 8.2869 (4.1); 8.2020 (2.2); 8.1826 (2.4); 7.8772 (2.1); 7.8588 (2.5); 7.6655 (9.4); 7.6398 (2.8); 7.6216 (1.4); 7.4922 (3.9); 7.3206 (1.6); 7.2996 (1.6); 7.2608 (23.5); 5.6281 (1.2); 5.6113 (1.9); 5.5938 (1.3); 3.9481 (16.0); 1.5606 (14.8); 1.4461 (7.6); 1.4293 (7.8); 1.2620 (0.6); -0.0002 (28.5) 35 I.2-10: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6634 (2.0); 8.6573 (2.5); 8.6063 (2.1); 8.6002 (1.7); 8.3326 (0.8); 8.3283 (1.5); 8.3250 (0.9); 8.3239 (0.9); 8.2458 (2.6); 8.2446 (2.6); 8.2434 (2.6); 8.2402 (1.3); 8.2359 (0.7); 8.2234 (0.6); 8.2194 (0.9); 8.2163 (0.6); 8.0139 (1.1); 7.9040 (0.5); 7.9010 (0.7); 7.8996 BCS241005-Ausland STR 205 (0.7); 7.8965 (0.6); 7.8849 (0.6); 7.8818 (0.7); 7.8804 (0.8); 7.8773 (0.6); 7.6713 (0.8); 7.6519 (1.5); 7.6335 (0.6); 7.6325 (0.7); 7.2630 (6.3); 5.6844 (0.5); 5.6655 (0.6); 5.6484 (0.5); 5.2998 (3.7); 4.5262 (1.3); 4.5186 (1.2); 4.5146 (1.4); 4.5111 (1.2); 4.5029 (1.5); 3.7576 (1.7); 3.7518 (0.6); 3.7456 (1.8); 3.7400 (0.6); 3.7338 (1.5); 3.4196 (16.0); 1.6293 (3.0); 1.4919 (4.0); 1.4752 (4.0); 1.2638 (0.9); 1.2595 5 (0.9); 0.8817 (1.6); 0.8639 (0.6); -0.0002 (7.6) I.2-11: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6703 (2.4); 8.6642 (2.9); 8.6091 (2.6); 8.6030 (2.1); 8.3110 (1.0); 8.3068 (1.9); 8.3029 (1.1); 8.2484 (3.2); 8.2172 (0.7); 8.2138 (1.0); 8.2102 (0.7); 8.1977 (0.8); 8.1940 (1.1); 8.1907 (0.7); 8.0143 (1.4); 7.8997 (0.6); 7.8955 (0.8); 7.8922 (0.7); 7.8805 (0.8); 7.8763 10 (1.0); 7.8731 (0.8); 7.6734 (1.0); 7.6541 (1.8); 7.6347 (0.8); 7.5020 (0.5); 7.4830 (0.5); 7.2612 (13.3); 5.6855 (0.6); 5.6667 (0.8); 5.6494 (0.6); 3.9527 (16.0); 1.4919 (5.2); 1.4752 (5.2); 0.0079 (0.5); -0.0002 (16.8); -0.0085 (0.5) I.2-12: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7137 (2.1); 8.6244 (2.0); 8.3798 (2.8); 8.2705 (1.7); 8.2531 15 (3.9); 7.9941 (3.2); 7.9627 (4.6); 7.8526 (1.8); 7.7374 (3.4); 7.7182 (1.4); 7.6989 (2.3); 7.6793 (1.1); 7.5835 (0.9); 7.5652 (0.9); 7.5186 (1.0); 7.2602 (172.6); 6.9967 (0.9); 5.6885 (0.8); 5.6712 (1.1); 5.6538 (0.8); 1.5210 (5.2); 1.5045 (5.0); 1.4792 (1.0); 1.4420 (1.9); 1.4270 (1.2); 1.4194 (0.6); 1.4091 (1.1); 1.3877 (0.6); 1.3331 (3.4); 1.2841 (5.4); 1.2546 (16.0); 1.2366 (2.2); 0.8941 (1.2); 0.8797 (2.4); 0.8617 (1.4); 0.1457 (0.7); 0.0289 (0.5); 0.0080 (6.5); -0.0002 (214.8); -0.0085 (6.1); -0.1494 (0.8) 20 I.2-15: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7058 (7.2); 8.6999 (8.5); 8.6269 (8.1); 8.6210 (7.2); 8.5535 (1.4); 8.3924 (7.0); 8.2753 (16.0); 8.2539 (4.0); 8.1187 (0.7); 7.9986 (6.2); 7.9882 (3.8); 7.9687 (3.7); 7.7488 (2.6); 7.7292 (3.0); 7.7217 (3.9); 7.7024 (6.0); 7.6834 (2.7); 7.2610 (75.4); 5.7328 (0.6); 5.7153 (2.2); 5.6973 (3.1); 5.6797 (2.3); 5.6632 (0.6); 5.3002 (2.5); 2.1302 (3.7); 1.5324 (14.5); 1.5156 (15.1); 25 1.3328 (0.7); 1.2843 (1.0); 1.2551 (4.0); 0.8805 (0.6); 0.0080 (1.2); -0.0002 (82.0); -0.0082 (5.0) I.2-16: 1H-NMR (400.6 MHz, CDCl3): δ= 7.6791 (1.0); 7.6745 (0.8); 7.2600 (6.3); 1.4755 (0.9); 1.4588 (0.9); 1.3329 (0.8); 1.2839 (2.0); 1.2556 (16.0); 1.1610 (0.6); 1.1429 (0.6); 1.1209 (0.5); 1.0758 (0.6); 0.8965 (1.3); 0.8801 (2.9); 0.8744 (2.1); 0.8698 (1.8); 0.8624 (1.9); 0.8529 (2.9); 0.8362 (2.2); -0.0002 30 (7.4) I.2-17: 1H-NMR (400.6 MHz, d6-DMSO): δ= 9.1837 (3.0); 9.1673 (3.1); 8.6839 (5.7); 8.6778 (10.2); 8.6637 (10.6); 8.6576 (6.1); 8.1864 (3.5); 8.1823 (6.4); 8.1782 (3.6); 8.0441 (2.1); 8.0410 (3.2); 8.0374 (2.1); 8.0248 (2.4); 8.0215 (3.5); 8.0180 (2.2); 7.9447 (6.1); 7.9408 (9.1); 7.9369 (5.2); 7.9264 (2.5); 35 7.9227 (3.2); 7.9193 (2.1); 7.7418 (4.2); 7.7141 (4.3); 7.7115 (4.4); 7.6590 (3.3); 7.6396 (5.9); 7.6204 (2.7); 5.3203 (1.9); 5.3034 (3.0); 5.2864 (2.0); 3.5739 (0.7); 3.5687 (0.7); 3.5087 (0.8); 3.3714 (0.7); 3.3406 (0.5); 3.1702 (16.0); 2.6767 (0.6); 2.6722 (0.8); 2.6676 (0.6); 2.5427 (0.6); 2.5258 (2.2); 2.5211 BCS241005-Ausland STR 206 (3.1); 2.5124 (47.5); 2.5079 (101.6); 2.5034 (139.6); 2.4989 (96.7); 2.4944 (42.8); 2.4717 (0.5); 2.3350 (0.6); 2.3305 (0.8); 2.3258 (0.6); 1.4888 (11.6); 1.4717 (11.6); 1.2588 (0.8); 1.2335 (6.0); 0.8530 (0.8); 0.0079 (1.6); -0.0002 (54.9); -0.0085 (1.6) 5 I.2-18: 1H-NMR (400.6 MHz, d6-DMSO): δ= 8.6838 (0.8); 8.6777 (1.5); 8.6632 (1.5); 8.6571 (0.9); 8.1855 (0.5); 8.1813 (0.9); 8.1772 (0.5); 8.0205 (0.5); 7.9458 (0.9); 7.9420 (1.4); 7.9380 (0.9); 7.7416 (0.6); 7.7146 (0.6); 7.7121 (0.6); 7.6392 (0.8); 3.1691 (16.0); 2.5127 (8.8); 2.5082 (19.0); 2.5037 (26.2); 2.4992 (18.3); 2.4947 (8.2); 1.4885 (1.7); 1.4714 (1.7); 1.2338 (0.8); -0.0002 (10.6) 10 I.2-19: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6766 (2.0); 8.6705 (2.6); 8.6300 (2.3); 8.6239 (1.8); 8.3603 (0.9); 8.3561 (1.6); 8.3517 (0.9); 8.2467 (2.7); 8.2399 (0.8); 8.2364 (0.9); 8.2325 (0.6); 8.2200 (0.7); 8.2166 (0.9); 8.2129 (0.6); 8.0217 (1.1); 7.9983 (0.6); 7.9951 (0.7); 7.9909 (0.5); 7.9791 (0.7); 7.9758 (0.8); 7.9717 (0.6); 7.7280 (0.9); 7.7085 (1.6); 7.6892 (0.7); 7.2611 (20.0); 5.6825 (0.5); 5.6655 (0.6); 5.6464 (0.5); 5.0096 (4.4); 5.0025 (4.4); 1.5596 (16.0); 1.4949 (4.3); 1.4781 (4.3); 0.0080 (0.7); -0.0002 15 (23.8); -0.0084 (0.6) I.2-20: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6477 (2.3); 8.6417 (3.0); 8.6016 (2.7); 8.5955 (2.1); 8.2908 (1.1); 8.2867 (2.0); 8.2828 (1.1); 8.2046 (0.7); 8.2014 (1.1); 8.1975 (0.7); 8.1850 (0.8); 8.1816 (1.2); 7.9961 (1.4); 7.9924 (2.8); 7.9888 (1.5); 7.8795 (0.9); 7.8755 (0.6); 7.8639 (0.9); 7.8599 (1.0); 7.8565 20 (0.8); 7.8374 (1.5); 7.8331 (2.4); 7.8290 (1.4); 7.7356 (1.6); 7.7313 (2.3); 7.7271 (1.3); 7.6580 (1.1); 7.6388 (1.9); 7.6192 (0.9); 7.2602 (66.4); 5.6215 (0.7); 5.6044 (0.8); 5.5853 (0.6); 3.9475 (16.0); 1.5476 (5.1); 1.4451 (5.4); 1.4284 (5.3); 0.0079 (3.1); -0.0002 (94.7); -0.0085 (2.7) I.2-21: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6606 (5.6); 8.6547 (6.5); 8.6206 (3.0); 8.6084 (9.6); 8.6027 25 (6.3); 8.3874 (5.8); 8.2912 (3.1); 8.2716 (3.3); 8.2382 (11.1); 8.0145 (4.8); 7.9207 (2.7); 7.9016 (3.2); 7.7455 (1.4); 7.7413 (1.3); 7.7263 (3.2); 7.7222 (2.9); 7.7070 (2.0); 7.7029 (1.9); 7.6942 (2.9); 7.6749 (4.9); 7.6555 (2.3); 7.5064 (3.8); 7.4868 (3.2); 7.4581 (2.0); 7.4388 (2.0); 7.3836 (0.6); 7.3623 (0.8); 7.2618 (26.0); 7.2525 (2.7); 7.2333 (1.9); 5.6899 (1.9); 5.6724 (2.6); 5.6542 (1.9); 5.5309 (16.0); 4.8436 (2.3); 2.0456 (1.9); 1.4859 (12.8); 1.4693 (12.8); 1.2847 (0.7); 1.2770 (0.9); 1.2594 (2.1); 1.2420 (0.7); 30 0.8819 (0.8); -0.0002 (35.1) I.2-22: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6434 (2.1); 8.6379 (2.5); 8.5898 (2.4); 8.5840 (2.1); 8.2892 (2.4); 8.2749 (2.5); 8.1996 (1.3); 8.1800 (1.4); 7.8888 (1.1); 7.8719 (1.4); 7.7177 (1.1); 7.6972 (1.4); 7.6569 (1.2); 7.6373 (1.9); 7.6181 (0.9); 7.5122 (2.2); 7.4915 (1.8); 7.2836 (1.3); 7.2605 (41.3); 7.2580 35 (37.5); 5.6305 (0.8); 5.6134 (1.2); 5.5959 (0.8); 3.9456 (12.1); 3.9434 (11.0); 1.5526 (16.0); 1.4475 (5.2); 1.4308 (5.2); -0.0002 (52.2); -0.0027 (47.4); -0.0302 (0.7) BCS241005-Ausland STR 207 I.2-23: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6401 (3.0); 8.6361 (3.5); 8.5862 (3.2); 8.5822 (2.8); 8.2917 (1.4); 8.2889 (2.6); 8.2861 (1.5); 8.1967 (0.9); 8.1945 (1.4); 8.1922 (0.9); 8.1837 (1.0); 8.1814 (1.4); 8.1792 (0.9); 8.0627 (3.0); 8.0593 (3.0); 7.8843 (0.8); 7.8819 (1.1); 7.8794 (0.9); 7.8715 (1.0); 7.8690 (1.3); 7.8667 (0.9); 7.6849 (1.4); 7.6814 (1.4); 7.6711 (1.7); 7.6676 (1.7); 7.6493 (1.3); 7.6364 (2.4); 5 7.6235 (1.2); 7.5225 (3.2); 7.5087 (2.7); 7.3061 (0.7); 7.2929 (0.7); 7.2596 (40.5); 7.2536 (0.4); 5.6303 (0.8); 5.6188 (1.0); 5.6063 (0.8); 5.2981 (1.5); 3.9449 (18.9); 2.6130 (10.5); 1.5483 (44.5); 1.4435 (6.6); 1.4324 (6.6); 1.2542 (0.8); 0.0691 (5.5); 0.0051 (1.6); -0.0001 (50.0); -0.0058 (1.8) I.2-24: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6476 (2.3); 8.6415 (3.0); 8.5990 (2.7); 8.5929 (2.1); 8.2913 10 (1.1); 8.2871 (2.0); 8.2829 (1.1); 8.2043 (0.7); 8.2009 (1.0); 8.1973 (0.7); 8.1847 (0.8); 8.1812 (1.2); 8.1778 (0.8); 7.8989 (1.3); 7.8954 (2.4); 7.8919 (1.4); 7.8837 (0.7); 7.8803 (0.9); 7.8761 (0.7); 7.8644 (0.8); 7.8611 (1.0); 7.8571 (0.8); 7.6579 (1.1); 7.6386 (1.9); 7.6194 (0.9); 7.5853 (0.6); 7.5793 (0.8); 7.5757 (0.7); 7.5663 (0.6); 7.5605 (0.8); 7.5567 (0.7); 7.4948 (0.7); 7.4911 (0.8); 7.4852 (0.6); 7.4726 (0.7); 7.4690 (0.8); 7.4632 (0.6); 7.2946 (0.6); 7.2745 (0.6); 7.2603 (47.9); 7.2309 (0.5); 5.6265 (0.7);15 5.6090 (0.8); 5.5902 (0.6); 3.9472 (16.0); 1.5443 (15.8); 1.4448 (5.4); 1.4281 (5.4); 0.0079 (1.7); - 0.0002 (67.9); -0.0085 (2.2); -0.0295 (0.7) I.2-25: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6441 (0.8); 8.6400 (0.8); 8.5812 (0.7); 8.5772 (0.6); 8.2938 (0.3); 8.2911 (0.6); 8.2886 (0.3); 8.1969 (0.3); 8.1835 (0.3); 7.8035 (0.4); 7.8010 (0.3); 7.6710 (0.3); 20 7.6676 (0.3); 7.6571 (0.4); 7.6536 (0.7); 7.6400 (0.6); 7.5577 (0.8); 7.5438 (0.6); 7.2630 (8.2); 3.9453 (5.0); 3.4872 (16.2); 2.0124 (0.6); 2.0047 (50.0); 1.9959 (0.4); 1.5865 (1.0); 1.4501 (1.6); 1.4389 (1.6); 0.9856 (0.5); 0.0053 (0.3); -0.0001 (9.4) I.2-26: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6437 (1.0); 8.6396 (1.1); 8.5810 (1.0); 8.5770 (0.9); 8.2941 25 (0.4); 8.2914 (0.8); 8.2888 (0.5); 8.1962 (0.4); 8.1940 (0.3); 8.1855 (0.3); 8.1831 (0.5); 8.1809 (0.3); 7.8866 (0.4); 7.8762 (0.3); 7.8736 (0.4); 7.8714 (0.3); 7.8044 (0.6); 7.6723 (0.4); 7.6690 (0.4); 7.6584 (0.6); 7.6550 (0.6); 7.6534 (0.5); 7.6400 (0.8); 7.6271 (0.4); 7.5575 (1.0); 7.5436 (0.8); 7.2650 (5.2); 5.6266 (0.4); 5.2998 (1.7); 4.1392 (0.4); 4.1273 (1.2); 4.1154 (1.2); 4.1035 (0.4); 3.9451 (6.0); 3.4849 (15.5); 2.1160 (0.3); 2.0431 (5.5); 2.0268 (0.5); 2.0123 (0.4); 2.0046 (50.0); 1.9960 (0.6); 1.8897 (0.3); 30 1.6139 (0.4); 1.4506 (2.1); 1.4394 (2.1); 1.3023 (0.4); 1.2902 (0.5); 1.2805 (0.5); 1.2771 (0.4); 1.2705 (2.0); 1.2656 (1.1); 1.2586 (3.4); 1.2468 (1.7); 0.8936 (1.2); 0.8821 (2.9); 0.8702 (1.4); -0.0001 (6.0) I.2-27: 1H-NMR (600 MHz, CDCl3): δ= 8.6497 (6.4); 8.6457 (7.4); 8.5979 (7.6); 8.5939 (6.7); 8.2922 (3.9); 8.2895 (7.1); 8.2868 (4.2); 8.2010 (2.4); 8.1989 (3.8); 8.1968 (2.5); 8.1880 (2.6); 8.1859 (4.0); 35 8.1838 (2.6); 7.8772 (2.3); 7.8750 (3.2); 7.8726 (2.4); 7.8645 (2.6); 7.8621 (3.6); 7.8599 (2.7); 7.8506 (4.7); 7.8481 (8.3); 7.8457 (5.0); 7.6529 (3.6); 7.6400 (6.6); 7.6271 (3.1); 7.6039 (5.1); 7.5210 (5.0); 7.3336 (2.0); 7.3207 (2.1); 7.2600 (43.9); 7.2429 (0.4); 5.6418 (0.6); 5.6305 (2.3); 5.6185 (3.0); 5.6066 BCS241005-Ausland STR 208 (2.4); 5.5953 (0.7); 5.2981 (3.1); 3.9475 (47.6); 3.9304 (0.5); 2.6138 (1.4); 1.5590 (30.0); 1.4498 (17.3); 1.4386 (17.5); 1.2541 (2.2); 0.0051 (1.8); -0.0001 (50.0); -0.0055 (2.1); -0.0172 (0.5) I.2-28: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6497 (7.8); 8.6458 (8.8); 8.5978 (9.0); 8.5939 (7.8); 8.2900 5 (8.6); 8.1990 (4.6); 8.1860 (4.8); 7.8756 (4.2); 7.8628 (4.8); 7.8485 (9.4); 7.6529 (4.3); 7.6400 (7.7); 7.6272 (3.7); 7.6042 (6.8); 7.5211 (6.6); 7.3373 (2.8); 7.3245 (2.8); 7.2605 (29.3); 5.6422 (0.8); 5.6309 (2.9); 5.6190 (4.0); 5.6071 (2.9); 5.5958 (0.8); 5.2980 (1.8); 3.9683 (0.4); 3.9474 (50.0); 2.6147 (1.2); 1.5730 (11.7); 1.4500 (20.0); 1.4388 (20.1); 1.3338 (0.4); 1.2848 (0.5); 1.2557 (1.4); -0.0001 (33.8) 10 I.2-29: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6497 (7.8); 8.6458 (8.8); 8.5978 (9.0); 8.5939 (7.8); 8.2900 (8.6); 8.1990 (4.6); 8.1860 (4.8); 7.8756 (4.2); 7.8628 (4.8); 7.8485 (9.4); 7.6529 (4.3); 7.6400 (7.7); 7.6272 (3.7); 7.6042 (6.8); 7.5211 (6.6); 7.3373 (2.8); 7.3245 (2.8); 7.2621 (7.1); 3.9473 (1.2); 3.4925 (4.9); 3.4839 (5.1); 2.0121 (0.7); 2.0046 (50.0); 1.9959 (0.4); 1.5640 (2.9); 1.4480 (0.4); 1.4369 (0.4); 0.9592 (0.3); 0.9503 (0.9); 0.9416 (0.9); 0.0055 (0.3); -0.0001 (9.4); -0.0053 (0.3) 15 I.2-30: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6497 (6.4); 8.6457 (7.4); 8.5979 (7.6); 8.5939 (6.7); 8.2922 (3.9); 8.2895 (7.1); 8.2868 (4.2); 8.2010 (2.4); 8.1989 (3.8); 8.1968 (2.5); 8.1880 (2.6); 8.1859 (4.0); 8.1838 (2.6); 7.8772 (2.3); 7.8750 (3.2); 7.8726 (2.4); 7.8645 (2.6); 7.8621 (3.6); 7.8599 (2.7); 7.8506 (4.7); 7.8481 (8.3); 7.8457 (5.0); 7.6529 (3.6); 7.6400 (6.6); 7.6271 (3.1); 7.6039 (5.1); 7.5210 (5.0); 20 7.3336 (2.0); 7.3207 (2.1); 7.2594 (35.9); 3.9475 (1.0); 3.4953 (9.6); 3.4860 (9.7); 2.0432 (0.6); 2.0042 (50.0); 1.9956 (0.4); 1.9807 (0.4); 1.5343 (29.7); 1.4470 (0.4); 1.4359 (0.4); 1.2656 (0.6); 1.2588 (0.6); 1.2469 (0.3); 0.9130 (0.8); 0.9037 (2.5); 0.8944 (3.1); 0.8851 (1.1); 0.8823 (1.6); 0.8704 (0.8); 0.0053 (1.7); -0.0001 (48.8); -0.0053 (1.7); -0.0236 (0.4) 25 I.2-31: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6415 (7.4); 8.6375 (8.7); 8.5928 (8.6); 8.5888 (7.5); 8.3038 (4.1); 8.3011 (7.6); 8.2984 (4.6); 8.1951 (4.0); 8.1820 (4.2); 7.9181 (3.4); 7.9053 (3.8); 7.9028 (3.1); 7.7462 (0.8); 7.6528 (3.8); 7.6399 (7.0); 7.6271 (3.4); 7.5908 (7.6); 7.4390 (5.2); 7.3275 (1.8); 7.3148 (1.8); 7.2994 (1.0); 7.2599 (37.5); 7.2010 (5.1); 5.6646 (0.7); 5.6533 (2.5); 5.6413 (3.2); 5.6293 (2.5); 5.6180 (0.7); 5.2975 (0.5); 3.9428 (49.8); 3.9229 (0.4); 3.4898 (0.6); 3.0144 (0.5); 3.0031 (1.4); 2.9918 30 (2.8); 2.9803 (3.4); 2.9688 (2.5); 2.9573 (1.0); 2.6262 (0.3); 2.0034 (1.1); 1.6611 (0.3); 1.5719 (0.4); 1.5609 (0.4); 1.4662 (18.1); 1.4550 (18.2); 1.2987 (7.1); 1.2871 (7.4); 1.2790 (41.6); 1.2675 (41.5); 1.2478 (0.5); 0.9501 (0.5); 0.0052 (1.7); -0.0001 (50.0); -0.0054 (2.0); -0.0201 (0.3) I.2-32: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6375 (3.1); 8.6336 (3.6); 8.5922 (3.4); 8.5883 (2.9); 8.2999 35 (3.4); 8.1943 (1.7); 8.1812 (1.8); 7.9154 (1.7); 7.9027 (1.9); 7.6526 (1.6); 7.6397 (2.8); 7.6268 (1.4); 7.5898 (3.7); 7.4388 (2.7); 7.3144 (0.8); 7.3025 (0.9); 7.2634 (10.0); 7.2026 (2.6); 5.6505 (1.0); 5.6386 (1.4); 5.6267 (1.0); 3.9426 (17.3); 3.4840 (9.4); 3.0054 (0.4); 2.9939 (1.0); 2.9824 (1.4); 2.9709 (1.0); BCS241005-Ausland STR 209 2.9594 (0.4); 2.0032 (50.0); 1.9876 (0.4); 1.9829 (0.5); 1.4634 (8.1); 1.4522 (8.2); 1.2952 (0.7); 1.2806 (15.6); 1.2691 (15.4); -0.0001 (10.4) I.2-33: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6428 (5.2); 8.6387 (6.1); 8.5922 (5.8); 8.5881 (5.0); 8.3005 5 (2.8); 8.2978 (5.0); 8.2950 (2.9); 8.1996 (1.8); 8.1975 (2.7); 8.1953 (1.8); 8.1865 (1.8); 8.1844 (2.7); 8.1823 (1.7); 8.0695 (9.6); 7.8994 (1.7); 7.8971 (2.4); 7.8948 (1.7); 7.8867 (1.9); 7.8843 (2.6); 7.8821 (1.8); 7.8608 (5.4); 7.6542 (2.7); 7.6414 (7.6); 7.6284 (2.2); 7.6090 (3.4); 7.3574 (1.6); 7.3445 (1.6); 7.2615 (19.5); 5.6639 (0.5); 5.6526 (1.7); 5.6407 (2.1); 5.6286 (1.6); 5.6173 (0.4); 4.0342 (0.5); 4.0147 (33.1); 3.9645 (0.5); 3.9450 (33.4); 3.4870 (13.2); 2.0230 (0.7); 2.0175 (0.4); 2.0034 (50.0); 1.9949 10 (0.3); 1.5850 (1.8); 1.4670 (12.2); 1.4558 (12.2); 0.0195 (0.3); 0.0053 (1.1); -0.0001 (25.6); -0.0054 (0.7) I.2-34: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6428 (8.4); 8.6388 (9.7); 8.5920 (9.2); 8.5880 (8.0); 8.2979 (8.2); 8.1976 (4.4); 8.1845 (4.6); 8.0692 (15.0); 7.8966 (4.0); 7.8838 (4.4); 7.8601 (9.0); 7.6539 (4.2); 15 7.6411 (12.9); 7.6281 (3.6); 7.6090 (6.1); 7.3540 (2.9); 7.3410 (2.9); 7.2608 (24.8); 5.6645 (0.8); 5.6532 (2.7); 5.6411 (3.6); 5.6293 (2.7); 5.6180 (0.7); 4.0652 (0.3); 4.0346 (0.4); 4.0146 (49.7); 3.9650 (0.3); 3.9450 (50.0); 3.4872 (0.8); 2.6119 (0.6); 2.0031 (19.8); 1.5831 (12.4); 1.4667 (19.2); 1.4555 (19.2); 1.2562 (0.7); 0.0051 (1.7); -0.0001 (33.1) 20 I.2-35: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6414 (2.4); 8.6353 (3.0); 8.5955 (2.7); 8.5894 (2.1); 8.3000 (1.0); 8.2958 (2.0); 8.2918 (1.1); 8.2021 (0.7); 8.1986 (1.1); 8.1951 (0.7); 8.1827 (0.8); 8.1790 (1.1); 8.1755 (0.7); 7.9127 (0.6); 7.9089 (0.8); 7.9053 (0.7); 7.8936 (0.8); 7.8894 (1.0); 7.8862 (0.8); 7.6586 (1.1); 7.6394 (1.9); 7.6200 (0.9); 7.5254 (1.7); 7.4497 (1.3); 7.3128 (0.5); 7.2931 (0.6); 7.2603 (57.4); 7.1671 (1.2); 5.6515 (0.6); 5.6341 (0.8); 5.6153 (0.6); 3.9437 (16.0); 2.4473 (1.7); 2.4311 (8.5); 1.5474 25 (2.1); 1.4583 (5.4); 1.4416 (5.3); 0.0080 (2.5); -0.0002 (79.4); -0.0085 (2.1) I.2-36: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6750 (2.4); 8.6690 (2.9); 8.6117 (2.6); 8.6056 (2.2); 8.2963 (1.1); 8.2922 (2.0); 8.2881 (1.2); 8.2144 (0.7); 8.2110 (1.1); 8.2074 (0.7); 8.1948 (0.8); 8.1914 (1.1); 8.1879 (0.7); 8.0061 (1.4); 8.0026 (2.6); 7.9992 (1.5); 7.9252 (1.3); 7.8679 (0.6); 7.8644 (0.9); 7.8605 30 (0.7); 7.8487 (0.8); 7.8448 (1.0); 7.8413 (0.8); 7.6670 (1.1); 7.6475 (2.1); 7.6407 (1.2); 7.6382 (1.4); 7.6357 (1.2); 7.6286 (1.0); 7.5039 (0.6); 7.4846 (0.6); 7.2628 (6.3); 5.6509 (0.7); 5.6334 (0.8); 5.6152 (0.7); 3.9535 (16.0); 1.4578 (5.3); 1.4412 (5.2); -0.0002 (8.5) I.2-37: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6565 (2.3); 8.6504 (2.9); 8.6030 (2.6); 8.5970 (2.1); 8.2924 35 (1.0); 8.2884 (1.9); 8.2844 (1.1); 8.2078 (0.7); 8.2045 (1.0); 8.2007 (0.7); 8.1882 (0.8); 8.1847 (1.1); 8.1812 (0.7); 7.9662 (2.6); 7.9612 (2.9); 7.8787 (0.6); 7.8756 (0.8); 7.8712 (0.7); 7.8596 (0.8); 7.8552 (1.1); 7.8507 (3.2); 7.8456 (2.7); 7.6613 (1.0); 7.6421 (1.8); 7.6228 (0.8); 7.3223 (0.5); 7.3029 (0.6); BCS241005-Ausland STR 210 7.2623 (15.3); 5.6212 (0.6); 5.6042 (0.8); 5.5852 (0.6); 3.9501 (16.0); 2.0478 (0.6); 1.5861 (2.0); 1.4468 (5.0); 1.4301 (5.0); 0.0079 (0.7); -0.0002 (21.5); -0.0085 (0.6) I.2-38: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6467 (2.4); 8.6406 (2.9); 8.5917 (2.5); 8.5856 (2.0); 8.2939 5 (1.0); 8.2900 (1.8); 8.2861 (1.0); 8.2042 (0.7); 8.2010 (1.0); 8.1971 (0.7); 8.1847 (0.8); 8.1811 (1.0); 8.1776 (0.7); 8.0558 (2.4); 8.0506 (2.4); 7.8914 (0.6); 7.8883 (0.8); 7.8839 (0.7); 7.8722 (0.8); 7.8679 (0.9); 7.8647 (0.7); 7.7047 (2.0); 7.6840 (2.8); 7.6594 (1.0); 7.6402 (1.7); 7.6209 (0.8); 7.5993 (1.6); 7.5941 (1.5); 7.5785 (1.1); 7.5733 (1.1); 7.3249 (0.5); 7.3054 (0.5); 7.2619 (36.1); 5.6343 (0.6); 5.6173 (0.7); 5.5981 (0.6); 3.9465 (16.0); 1.5625 (7.5); 1.4465 (4.9); 1.4299 (4.9); 0.0080 (1.4); -0.0002 (51.9); 10 -0.0085 (1.6) I.2-39: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6480 (2.3); 8.6419 (2.9); 8.5920 (2.6); 8.5859 (2.1); 8.2951 (1.0); 8.2909 (2.0); 8.2865 (1.1); 8.2045 (0.7); 8.2007 (1.0); 8.1975 (0.7); 8.1850 (0.8); 8.1811 (1.1); 8.1780 (0.8); 7.9062 (2.3); 7.9011 (2.4); 7.8918 (0.7); 7.8875 (0.9); 7.8843 (0.7); 7.8726 (0.8); 7.8683 15 (1.0); 7.8652 (0.8); 7.6591 (1.1); 7.6490 (1.2); 7.6438 (1.2); 7.6398 (2.0); 7.6282 (1.6); 7.6229 (1.8); 7.5306 (2.8); 7.5099 (2.0); 7.3441 (0.5); 7.3249 (0.5); 7.2626 (12.1); 5.6392 (0.6); 5.6202 (0.8); 5.6031 (0.6); 3.9465 (16.0); 2.0476 (0.6); 1.5983 (1.0); 1.4475 (5.1); 1.4308 (5.1); 1.2606 (0.5); -0.0002 (17.3); -0.0085 (0.5) 20 I.2-40: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6566 (2.3); 8.6506 (2.9); 8.6023 (2.5); 8.5963 (2.0); 8.2923 (1.0); 8.2884 (1.8); 8.2846 (1.0); 8.2077 (0.7); 8.2045 (1.0); 8.2006 (0.7); 8.1882 (0.8); 8.1849 (1.0); 8.1811 (0.7); 7.8776 (0.6); 7.8746 (0.8); 7.8733 (0.8); 7.8701 (0.6); 7.8585 (0.8); 7.8553 (0.9); 7.8541 (0.9); 7.8510 (0.7); 7.8092 (11.4); 7.6611 (1.0); 7.6421 (1.7); 7.6231 (0.8); 7.3208 (0.5); 7.2626 (12.0); 5.6234 (0.6); 5.6064 (0.7); 5.5874 (0.6); 3.9501 (16.0); 1.5911 (1.6); 1.4457 (4.9); 1.4290 (4.9); 0.0080 25 (0.5); -0.0002 (17.1) I.2-41: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6330 (2.7); 8.6271 (3.2); 8.5882 (3.3); 8.5823 (2.5); 8.1617 (2.8); 8.1562 (2.8); 8.0627 (2.9); 8.0578 (2.8); 7.8208 (1.4); 7.8154 (1.3); 7.8003 (1.7); 7.7949 (1.6); 7.6900 (1.5); 7.6850 (1.4); 7.6692 (2.0); 7.6639 (2.1); 7.6589 (3.2); 7.6382 (2.4); 7.5317 (3.0); 7.5110 30 (2.3); 7.2629 (13.0); 7.2339 (1.1); 7.2140 (1.1); 5.6364 (1.0); 5.6179 (1.3); 5.6000 (1.0); 4.1487 (0.6); 4.1311 (1.8); 4.1132 (1.8); 4.0952 (0.7); 4.0647 (0.6); 3.9518 (16.0); 2.0476 (9.3); 1.5817 (8.2); 1.4498 (6.6); 1.4331 (6.5); 1.2783 (2.1); 1.2605 (4.1); 1.2427 (2.1); 0.9357 (0.9); -0.0002 (16.0) I.2-42: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6428 (2.5); 8.6368 (3.2); 8.6004 (3.1); 8.5945 (2.4); 8.1621 35 (2.6); 8.1566 (2.6); 7.8512 (1.8); 7.8476 (2.9); 7.8439 (1.7); 7.8100 (1.3); 7.8044 (1.2); 7.7894 (1.7); 7.7838 (1.6); 7.6630 (2.8); 7.6423 (2.2); 7.6037 (2.0); 7.5295 (1.9); 7.2623 (14.6); 7.2362 (1.0); 5.6373 BCS241005-Ausland STR 211 (0.8); 5.6198 (1.1); 5.6010 (0.8); 3.9550 (16.0); 1.5733 (5.7); 1.4560 (5.9); 1.4393 (6.0); -0.0002 (17.7); -0.0084 (1.0) I.2-43: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6833 (2.2); 8.6750 (2.3); 8.6600 (2.6); 8.6542 (3.6); 8.6391 5 (3.6); 8.6333 (2.2); 7.9889 (0.8); 7.9753 (2.4); 7.9557 (2.0); 7.7216 (1.7); 7.6885 (3.2); 7.6842 (3.4); 7.6747 (2.3); 7.6334 (0.7); 7.6164 (0.7); 7.5813 (1.5); 7.5516 (1.8); 7.5328 (4.4); 7.5122 (2.8); 7.4979 (2.6); 7.3707 (3.7); 7.2635 (15.7); 7.1718 (1.1); 7.1533 (1.1); 5.2610 (0.5); 5.2440 (0.8); 5.2262 (0.6); 5.2038 (1.0); 5.1862 (1.4); 5.1683 (1.0); 4.1491 (1.1); 4.1312 (3.0); 4.1134 (3.1); 4.0955 (1.1); 4.0819 (0.6); 4.0650 (1.1); 4.0484 (0.6); 3.9677 (14.2); 3.9445 (7.6); 2.0476 (16.0); 1.5978 (9.4); 1.4658 (6.2); 10 1.4489 (6.2); 1.3912 (0.6); 1.3722 (0.8); 1.3571 (3.5); 1.3406 (3.3); 1.2783 (3.5); 1.2605 (6.8); 1.2426 (3.5); 0.9541 (0.9); 0.9357 (1.6); 0.9173 (0.8); -0.0002 (19.6) I.2-44: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6495 (2.4); 8.6437 (3.4); 8.6229 (3.4); 8.6170 (2.3); 8.1980 (3.0); 8.1713 (2.0); 8.1671 (2.7); 7.8862 (1.8); 7.8819 (2.8); 7.8776 (1.6); 7.6991 (2.8); 7.5573 (2.1); 15 7.3745 (2.0); 7.2623 (14.2); 7.2405 (1.1); 5.5884 (0.9); 5.5706 (1.2); 5.5527 (0.9); 3.9577 (16.0); 1.5745 (7.4); 1.4929 (6.3); 1.4762 (6.3); 1.2629 (0.8); 0.8819 (0.9); -0.0002 (16.7) I.2-45: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6714 (1.1); 8.1397 (1.1); 8.1347 (0.9); 8.1189 (1.1); 8.1138 (1.1); 8.0858 (0.8); 7.6441 (1.0); 7.6229 (0.9); 7.5287 (1.1); 7.5084 (0.9); 7.2620 (22.4); 3.9387 (1.8); 20 3.9193 (1.4); 2.0479 (2.1); 1.5588 (16.0); 1.4314 (0.7); 1.3497 (0.8); 1.3360 (0.8); 1.2606 (0.7); -0.0002 (27.4); -0.0084 (1.4) I.2-46: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6750 (1.8); 8.6649 (2.0); 8.6582 (1.4); 8.6507 (2.6); 8.6448 (3.5); 8.6278 (3.4); 8.6218 (2.1); 7.9833 (0.7); 7.9706 (2.4); 7.9586 (1.1); 7.9512 (2.1); 7.9188 (1.5); 25 7.9138 (1.4); 7.8833 (2.9); 7.8786 (2.6); 7.7028 (1.4); 7.6988 (1.4); 7.6839 (1.8); 7.6799 (1.6); 7.6600 (0.8); 7.6392 (1.0); 7.6201 (1.4); 7.6148 (1.3); 7.5989 (2.4); 7.5942 (2.1); 7.5787 (0.7); 7.5489 (1.8); 7.5290 (4.6); 7.5241 (4.1); 7.5034 (4.1); 7.4931 (2.5); 7.2628 (25.8); 7.1466 (1.0); 7.1285 (1.0); 5.2420 (0.7); 5.2246 (0.6); 5.2042 (1.0); 5.1861 (1.3); 5.1682 (0.9); 4.1489 (1.1); 4.1312 (3.1); 4.1134 (3.1); 4.0955 (1.1); 4.0815 (0.5); 4.0648 (0.9); 3.9657 (14.1); 3.9399 (6.9); 2.0476 (16.0); 1.6096 (0.6); 1.5805 30 (15.8); 1.4579 (6.0); 1.4410 (6.0); 1.3912 (0.5); 1.3550 (3.2); 1.3386 (3.0); 1.2784 (3.7); 1.2605 (7.2); 1.2427 (3.6); 0.9540 (0.7); 0.9358 (1.4); 0.9173 (0.7); -0.0002 (31.9); -0.0083 (1.7) I.2-47: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6402 (0.6); 8.6342 (0.7); 8.6117 (0.7); 8.1985 (0.7); 8.1631 (0.6); 7.8983 (0.7); 7.8929 (1.0); 7.8877 (0.6); 7.5308 (0.7); 7.2617 (22.6); 3.9551 (3.6); 2.0481 (0.6); 35 1.5505 (16.0); 1.4878 (1.4); 1.4712 (1.4); -0.0002 (27.9); -0.0083 (1.6) BCS241005-Ausland STR 212 I.2-49: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7005 (2.5); 8.6945 (3.0); 8.6441 (2.7); 8.6380 (2.2); 8.3330 (1.2); 8.3288 (2.2); 8.3248 (1.2); 8.2488 (3.6); 8.2205 (0.7); 8.2170 (1.1); 8.2136 (0.8); 8.2009 (0.8); 8.1973 (1.2); 8.1941 (0.8); 8.0172 (1.6); 7.8975 (0.7); 7.8943 (1.0); 7.8901 (0.7); 7.8783 (0.9); 7.8751 (1.1); 7.8709 (0.8); 7.6661 (1.2); 7.6467 (2.5); 7.6273 (1.3); 7.2627 (15.0); 6.1122 (0.6); 6.0956 (1.0); 5 6.0764 (0.7); 6.0282 (0.7); 6.0030 (0.8); 5.9862 (1.1); 5.9695 (0.6); 5.9604 (0.7); 5.9441 (0.6); 5.3147 (1.5); 5.2893 (1.4); 5.1289 (1.4); 5.0862 (1.3); 3.9539 (16.0); -0.0002 (10.8) I.2-50: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6882 (2.9); 8.6825 (3.2); 8.6338 (3.4); 8.6284 (2.7); 8.3150 (3.1); 8.2061 (1.8); 8.1866 (1.9); 8.1515 (1.1); 7.8869 (2.3); 7.8633 (7.3); 7.8600 (7.7); 7.7939 (3.2); 10 7.6524 (1.6); 7.6331 (2.6); 7.6138 (1.3); 7.5083 (1.3); 7.4892 (1.3); 7.2627 (9.2); 6.0595 (0.9); 6.0422 (1.8); 6.0241 (1.3); 5.9999 (0.9); 5.9843 (0.5); 5.9752 (0.9); 5.9580 (1.3); 5.9418 (0.7); 5.9327 (0.8); 5.9168 (0.6); 5.3017 (5.5); 5.2841 (2.5); 5.2592 (2.2); 5.1017 (2.3); 5.0596 (2.1); 3.9479 (16.0); 1.2560 (1.0); 0.8807 (0.6); -0.0002 (11.4); -0.0016 (11.2) 15 I.2-51: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6343 (2.8); 8.6283 (3.2); 8.5813 (3.2); 8.5754 (2.5); 8.3198 (2.8); 8.1973 (1.5); 8.1777 (1.6); 7.9471 (1.4); 7.9273 (2.0); 7.9213 (3.3); 7.9161 (2.9); 7.6644 (2.7); 7.6443 (4.2); 7.6391 (2.0); 7.6252 (1.3); 7.5374 (3.1); 7.5166 (2.3); 7.2633 (7.8); 7.2136 (1.0); 7.1927 (1.0); 5.6068 (0.5); 5.5879 (1.0); 5.5717 (1.0); 5.5523 (0.5); 5.3017 (5.7); 3.9499 (16.0); 2.0477 (1.1); 1.8592 (0.6); 1.8408 (1.0); 1.8227 (0.9); 1.8065 (0.7); 1.7839 (0.8); 1.7654 (1.2); 1.7474 (1.0); 1.7306 20 (0.7); 1.6078 (0.8); 1.2782 (0.7); 1.2607 (1.6); 1.2428 (0.6); 0.8816 (1.2); 0.8639 (0.6); 0.7835 (3.3); 0.7651 (6.7); 0.7465 (3.1); -0.0002 (9.8) I.2-52: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6419 (2.6); 8.6359 (3.2); 8.5927 (3.0); 8.5867 (2.4); 8.3230 (1.6); 8.3192 (2.5); 8.3152 (1.5); 8.2015 (1.3); 8.1850 (1.1); 8.1819 (1.4); 7.9352 (1.2); 7.9194 (1.1); 25 7.9160 (1.4); 7.7206 (1.8); 7.7167 (2.8); 7.7128 (1.7); 7.6670 (1.3); 7.6477 (2.2); 7.6283 (1.1); 7.5809 (1.9); 7.3795 (1.8); 7.2626 (9.1); 7.2219 (0.9); 7.2009 (0.9); 5.5897 (0.9); 5.5734 (0.9); 5.3016 (5.3); 3.9525 (16.0); 1.8474 (0.8); 1.8315 (0.7); 1.8133 (0.6); 1.7897 (0.6); 1.7712 (1.0); 1.7532 (0.8); 1.7364 (0.6); 1.5996 (4.6); 1.2637 (1.7); 0.8987 (0.8); 0.8821 (2.1); 0.8644 (0.9); 0.7889 (2.9); 0.7704 (6.2); 0.7519 (2.8); -0.0002 (11.1); -0.0083 (0.6) 30 I.2-53: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6768 (2.7); 8.6710 (3.2); 8.6238 (3.2); 8.6178 (2.5); 8.3159 (2.8); 8.2028 (1.5); 8.1832 (1.6); 7.9029 (3.0); 7.8979 (3.0); 7.8861 (1.6); 7.8668 (1.7); 7.6497 (2.7); 7.6296 (3.9); 7.6238 (2.0); 7.6113 (1.3); 7.5290 (3.1); 7.5082 (2.3); 7.4813 (1.1); 7.4617 (1.1); 7.2620 (18.4); 6.0715 (0.8); 6.0546 (1.5); 6.0359 (1.1); 5.9945 (0.8); 5.9792 (0.5); 5.9696 (0.8); 5.9529 (1.3); 35 5.9363 (0.7); 5.9273 (0.8); 5.9110 (0.7); 5.2738 (2.0); 5.2487 (1.9); 5.0953 (2.0); 5.0528 (1.8); 3.9464 (16.0); 2.1748 (0.6); 1.5693 (1.0); -0.0002 (22.8) BCS241005-Ausland STR 213 I.2-54: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6780 (2.6); 8.6721 (3.2); 8.6355 (3.2); 8.6295 (2.4); 8.3119 (2.6); 8.2049 (1.4); 8.1853 (1.5); 7.9942 (1.9); 7.9908 (3.0); 7.8797 (1.2); 7.8605 (1.5); 7.8393 (1.8); 7.8352 (2.7); 7.8310 (1.7); 7.7345 (1.9); 7.7306 (2.8); 7.7263 (1.6); 7.6515 (1.3); 7.6320 (2.3); 7.6128 (1.1); 7.4166 (0.9); 7.3981 (0.9); 7.2620 (26.9); 6.0529 (0.7); 6.0361 (1.3); 6.0175 (1.0); 5.9910 (0.8); 5 5.9661 (0.8); 5.9496 (1.2); 5.9331 (0.6); 5.9237 (0.8); 5.9077 (0.6); 5.2792 (1.9); 5.2542 (1.8); 5.0981 (1.8); 5.0557 (1.7); 3.9484 (16.0); 1.5616 (13.5); -0.0002 (32.9); -0.0082 (1.8) I.2-55: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6845 (1.0); 8.6785 (1.2); 8.6356 (1.2); 8.6296 (0.9); 8.3151 (1.0); 8.2073 (0.6); 8.1872 (0.6); 7.8601 (0.6); 7.7007 (1.1); 7.6535 (0.5); 7.6343 (0.9); 7.5634 (0.8); 10 7.3757 (0.8); 7.2617 (22.6); 6.0490 (0.5); 5.2841 (0.7); 5.2586 (0.6); 5.1024 (0.7); 5.0592 (0.6); 3.9494 (6.0); 1.5527 (16.0); -0.0002 (28.3); -0.0079 (1.6) I.2-56: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6824 (1.3); 8.1448 (1.3); 8.1241 (1.2); 8.1191 (1.1); 8.0925 (0.5); 7.8685 (0.6); 7.6481 (1.0); 7.6271 (1.4); 7.5871 (0.6); 7.5260 (1.4); 7.2617 (29.3); 3.9400 (2.2); 15 2.0480 (1.2); 1.5540 (16.0); 1.4362 (0.8); 1.3539 (1.0); 1.3404 (0.9); -0.0002 (34.7); -0.0081 (1.9) I.2-57: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6936 (7.7); 8.6876 (9.2); 8.6461 (8.9); 8.6400 (7.0); 8.3286 (7.7); 8.3231 (7.4); 7.8685 (5.3); 7.8608 (9.9); 7.8481 (5.3); 7.8425 (4.8); 7.6978 (8.1); 7.6770 (6.5); 7.6054 (6.0); 7.5096 (5.8); 7.4880 (3.2); 7.4690 (3.2); 7.2622 (77.8); 5.6905 (0.6); 5.6732 (2.4); 5.6554 20 (3.3); 5.6376 (2.4); 5.6210 (0.8); 5.3020 (0.6); 3.7753 (2.1); 3.7588 (5.5); 3.7423 (2.5); 1.8769 (2.1); 1.8604 (6.3); 1.8522 (3.0); 1.8439 (2.5); 1.4918 (15.2); 1.4750 (16.0); 1.4329 (1.1); 1.2564 (0.9); - 0.0002 (93.1); -0.1493 (0.7) I.2-58: δ= 8.7031 (13.8); 8.2351 (3.4); 8.1687 (6.1); 8.1456 (8.4); 7.8719 (4.9); 7.6792 (16.0); 7.6582 25 (15.2); 7.5988 (6.2); 7.5174 (7.3); 7.4550 (2.4); 7.2622 (160.4); 6.9979 (1.0); 5.3022 (4.4); 3.7716 (3.4); 3.7563 (8.9); 3.7400 (4.2); 2.1269 (2.3); 1.8755 (3.8); 1.8590 (9.8); 1.8504 (5.0); 1.8430 (4.2); 1.4707 (7.5); 1.4324 (3.8); 1.3810 (7.3); 1.2517 (1.7); -0.0002 (189.2); -0.1500 (1.5) I.2-59: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7183 (1.7); 8.7122 (2.8); 8.7064 (3.4); 8.7003 (4.0); 8.6932 30 (2.5); 8.6872 (1.6); 8.6624 (3.7); 8.6564 (2.8); 8.1211 (1.7); 8.1175 (1.7); 8.1016 (1.9); 8.0981 (1.8); 8.0764 (0.9); 8.0660 (1.1); 8.0528 (0.9); 7.7853 (1.7); 7.7814 (1.6); 7.7661 (2.1); 7.7625 (1.9); 7.7373 (2.7); 7.7175 (3.9); 7.5911 (3.2); 7.5713 (4.0); 7.5647 (3.1); 7.5525 (2.0); 7.5419 (3.4); 7.5317 (2.1); 7.4448 (1.6); 7.4259 (1.6); 7.3745 (1.7); 7.3592 (2.7); 7.2635 (17.9); 5.3021 (2.4); 5.2883 (0.9); 5.2714 (0.6); 5.2154 (1.1); 5.1976 (1.6); 5.1796 (1.1); 3.7839 (6.1); 3.7678 (14.4); 3.7519 (6.3); 3.6626 (0.5); 35 2.1275 (4.2); 1.8988 (0.7); 1.8815 (6.1); 1.8735 (7.5); 1.8653 (16.0); 1.8570 (7.4); 1.8492 (6.0); 1.8323 (1.0); 1.5177 (6.5); 1.5007 (6.6); 1.4328 (0.7); 1.3840 (3.8); 1.3674 (3.8); 0.9376 (0.6); -0.0002 (21.7) BCS241005-Ausland STR 214 I.2-60: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6910 (5.6); 8.6850 (7.1); 8.6533 (6.8); 8.6472 (5.0); 8.2885 (4.1); 8.2850 (6.4); 8.2814 (3.7); 8.2013 (4.1); 8.1971 (5.5); 8.1930 (3.5); 7.9537 (4.0); 7.9493 (5.9); 7.9448 (3.4); 7.7223 (4.0); 7.7185 (6.0); 7.7146 (3.6); 7.5658 (4.4); 7.5406 (2.6); 7.5213 (2.7); 7.3540 (4.1); 7.2629 (26.8); 5.6466 (1.7); 5.6290 (2.4); 5.6111 (1.8); 5.5940 (0.5); 5.3021 (0.8); 3.7781 (5.8); 5 3.7618 (14.2); 3.7559 (6.2); 3.7454 (6.1); 1.8959 (0.6); 1.8787 (5.8); 1.8709 (6.9); 1.8624 (16.0); 1.8540 (7.0); 1.8461 (5.9); 1.8292 (0.9); 1.5346 (11.2); 1.5178 (11.4); 1.4328 (0.5); -0.0002 (32.0); -0.0083 (1.9) I.2-61: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6937 (4.6); 8.6890 (5.2); 8.6424 (5.4); 8.6370 (4.2); 8.3421 10 (4.9); 8.3375 (4.6); 8.0593 (5.0); 8.0561 (4.9); 7.8686 (2.4); 7.8646 (2.2); 7.8481 (2.9); 7.8439 (2.7); 7.6870 (7.0); 7.6665 (6.3); 7.5676 (2.5); 7.5484 (2.7); 7.4905 (4.7); 7.4699 (3.9); 7.2637 (14.2); 7.2622 (13.3); 5.6734 (1.7); 5.6553 (2.4); 5.6381 (1.6); 5.3020 (1.1); 3.7776 (7.0); 3.7628 (15.4); 3.7465 (7.1); 2.1224 (3.3); 1.8948 (0.9); 1.8775 (6.6); 1.8690 (8.8); 1.8622 (16.0); 1.8538 (8.5); 1.8460 (6.4); 1.8288 (1.1); 1.4937 (10.1); 1.4770 (10.2); 1.4324 (0.8); 1.2554 (0.9); 1.2398 (0.6); -0.0002 (17.0); -0.0017 15 (16.4) I.2-62: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6977 (3.1); 8.6673 (1.3); 8.2478 (0.9); 8.1480 (1.6); 8.1286 (2.2); 8.0874 (0.9); 8.0511 (1.0); 7.6849 (1.1); 7.6647 (4.2); 7.6437 (3.4); 7.5802 (0.5); 7.5211 (0.8); 7.4960 (1.3); 7.2633 (16.3); 5.3021 (4.3); 3.7744 (6.3); 3.7587 (14.6); 3.7425 (6.4); 2.1211 (1.1); 1.8938 20 (1.0); 1.8764 (6.2); 1.8682 (7.8); 1.8603 (16.0); 1.8520 (7.6); 1.8441 (6.0); 1.8272 (1.0); 1.4909 (1.7); 1.4769 (1.8); 1.4325 (0.7); 1.3825 (1.6); -0.0002 (20.0) I.2-63: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6953 (6.3); 8.6820 (6.9); 8.6759 (9.1); 8.6700 (8.9); 8.6494 (8.3); 8.6435 (5.5); 8.1086 (3.3); 8.0925 (4.1); 8.0322 (2.3); 8.0204 (3.6); 8.0083 (2.4); 7.9052 (5.2); 25 7.8906 (7.0); 7.8863 (6.8); 7.7666 (3.5); 7.7483 (4.2); 7.6674 (2.1); 7.6476 (3.2); 7.6276 (3.5); 7.6079 (4.8); 7.5857 (4.8); 7.5659 (7.0); 7.5436 (9.6); 7.5324 (8.8); 7.5212 (10.0); 7.5005 (5.4); 7.2618 (276.0); 7.2220 (5.1); 7.2024 (4.4); 6.9988 (1.8); 5.2670 (2.1); 5.2502 (1.7); 5.2178 (2.3); 5.1991 (3.2); 5.1821 (2.4); 3.7700 (4.4); 3.7547 (11.0); 3.7391 (4.7); 2.1215 (5.8); 1.8739 (5.4); 1.8581 (12.9); 1.8499 (7.0); 1.8420 (5.5); 1.6737 (2.8); 1.4929 (15.5); 1.4762 (16.0); 1.4334 (2.8); 1.3833 (11.4); 1.3666 (11.2); 30 1.2544 (2.4); 0.1462 (1.7); -0.0002 (331.6); -0.1491 (2.0) I.2-64: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6457 (1.0); 8.6244 (1.0); 7.5206 (0.8); 7.2616 (132.5); 6.9982 (0.9); 5.3023 (1.0); 3.7485 (1.0); 2.1098 (1.0); 1.8549 (1.4); 1.5540 (16.0); 1.4993 (3.4); 1.4827 (2.9); 1.4324 (3.9); 1.2556 (3.4); 1.2437 (2.6); 1.2224 (1.7); 0.8800 (0.9); 0.1459 (1.2); -0.0002 (154.1); 35 -0.1496 (1.1) BCS241005-Ausland STR 215 I.2-65: 1H-NMR (400.6 MHz, d6-DMSO): δ= 9.2956 (0.8); 9.2783 (0.9); 8.7128 (1.4); 8.7068 (2.2); 8.6910 (2.3); 8.6850 (1.4); 8.1588 (2.6); 8.1537 (2.0); 8.0640 (0.8); 8.0444 (0.9); 7.9550 (0.8); 7.9357 (0.9); 7.8328 (1.4); 7.8119 (1.9); 7.7046 (1.1); 7.6989 (1.4); 7.6835 (1.0); 7.6783 (2.1); 7.6588 (0.7); 6.1676 (0.7); 5.8212 (0.8); 5.2486 (1.0); 5.2229 (0.9); 5.0219 (0.9); 4.9787 (0.9); 3.8419 (8.7); 3.3320 5 (16.0); 2.6710 (0.5); 2.5067 (64.6); 2.5023 (83.8); 2.4979 (60.9); 2.4937 (30.5); 2.3293 (0.6); -0.0002 (28.9); -0.0083 (1.7) I.2-66: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1342 (0.8); 9.1805 (2.8); 9.1642 (2.8); 8.6811 (5.7); 8.6651 (5.9); 8.3216 (1.8); 8.1736 (5.1); 8.0396 (3.5); 8.0194 (16.0); 7.9313 (2.8); 7.9122 (3.1); 7.6595 10 (2.0); 7.6405 (3.4); 7.6215 (1.8); 5.2971 (1.7); 5.2803 (2.5); 5.2636 (1.7); 3.3390 (6.1); 2.6757 (0.6); 2.5052 (85.0); 2.3331 (0.7); 1.4861 (8.9); 1.4694 (8.9); 1.2423 (4.3); 0.8572 (3.2); 0.8403 (1.7); -0.0002 (5.7) I.2-67: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6554 (2.6); 8.6494 (3.1); 8.6014 (3.1); 8.5954 (2.5); 8.2876 15 (2.6); 8.2040 (1.4); 8.1845 (1.5); 7.8730 (1.2); 7.8538 (1.5); 7.7849 (10.9); 7.6611 (1.3); 7.6417 (2.3); 7.6224 (1.1); 7.3390 (0.8); 7.3190 (0.9); 7.2622 (17.4); 5.6219 (0.9); 5.6039 (1.1); 5.5860 (0.9); 3.9498 (16.0); 2.0477 (0.6); 1.5698 (9.5); 1.4445 (6.1); 1.4278 (6.2); -0.0002 (21.5); -0.0081 (1.2) I.2-68: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1241 (2.9); 9.0933 (4.1); 9.0770 (4.1); 8.6735 (8.3); 20 8.6579 (8.7); 8.3219 (1.9); 8.1922 (7.6); 8.0496 (11.5); 8.0288 (5.0); 7.9517 (4.2); 7.9334 (4.6); 7.7783 (3.3); 7.7577 (5.6); 7.7108 (7.1); 7.6897 (4.2); 7.6653 (3.4); 7.6461 (5.3); 7.6270 (2.7); 5.3039 (2.5); 5.2868 (3.6); 5.2707 (2.4); 3.3414 (16.0); 2.6728 (1.1); 2.5057 (98.6); 2.3326 (1.1); 1.4757 (13.3); 1.4588 (13.0); 1.2436 (6.2); 0.8716 (2.5); 0.8571 (4.6); 0.8403 (2.3); -0.0002 (7.1) 25 I.2-69: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1289 (1.1); 9.1000 (2.4); 9.0835 (2.6); 8.6763 (3.9); 8.6706 (5.7); 8.6555 (6.0); 8.6496 (3.9); 8.3210 (2.4); 8.1912 (4.8); 8.1691 (5.0); 8.1644 (4.8); 8.0491 (2.5); 8.0296 (2.8); 7.9497 (2.4); 7.9303 (2.7); 7.8301 (3.3); 7.8092 (4.7); 7.7100 (2.9); 7.7054 (2.7); 7.6891 (2.3); 7.6847 (2.1); 7.6649 (2.2); 7.6456 (3.6); 7.6265 (1.8); 5.2946 (1.5); 5.2782 (2.2); 5.2612 (1.5); 3.3375 (16.0); 2.6725 (0.6); 2.5039 (105.3); 2.3307 (0.8); 1.4694 (8.2); 1.4525 (8.3); 1.2443 (2.6); 30 0.8732 (1.0); 0.8576 (2.4); 0.8400 (1.1); -0.0002 (10.1) I.2-70: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1155 (0.7); 9.1816 (0.8); 9.1651 (0.8); 8.6823 (1.7); 8.6612 (1.6); 8.1721 (1.6); 8.1478 (1.8); 8.0368 (2.2); 8.0236 (1.0); 7.9317 (0.8); 7.9135 (0.8); 7.6602 (0.6); 7.6422 (1.0); 5.2737 (0.7); 3.3346 (16.0); 2.6693 (1.6); 2.5695 (3.2); 2.5024 (72.0); 1.4817 (2.6); 35 1.4652 (2.4); 1.2438 (1.0); 0.8576 (0.7); -0.0002 (5.1) BCS241005-Ausland STR 216 I.2-71: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6345 (2.7); 8.6286 (3.4); 8.5909 (3.2); 8.5850 (2.5); 8.3484 (2.8); 8.1997 (1.4); 8.1801 (1.6); 7.9794 (1.3); 7.9603 (1.5); 7.8775 (3.1); 7.6759 (1.4); 7.6565 (2.6); 7.6444 (2.4); 7.6380 (2.1); 7.5394 (2.1); 7.2630 (9.3); 7.1608 (1.0); 7.1380 (1.1); 5.5485 (1.1); 5.5294 (1.4); 5.5261 (1.3); 5.5069 (1.1); 5.3018 (8.2); 3.9581 (16.0); 2.0340 (0.6); 2.0168 (1.0); 1.9995 (1.0); 5 1.9822 (0.6); 1.5977 (3.0); 1.2617 (0.6); 0.8863 (6.5); 0.8695 (6.3); 0.6474 (6.0); 0.6305 (6.0); -0.0002 (11.6); -0.0081 (0.8) I.2-72: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6304 (2.7); 8.6245 (3.2); 8.5757 (3.2); 8.5697 (2.5); 8.3752 (2.7); 8.1887 (1.4); 8.1690 (1.6); 7.9946 (1.3); 7.9757 (1.5); 7.9271 (2.9); 7.9222 (2.8); 7.6706 (1.4); 10 7.6655 (1.3); 7.6497 (3.1); 7.6448 (1.9); 7.6304 (2.5); 7.6110 (1.2); 7.5395 (3.1); 7.5188 (2.3); 7.2620 (23.6); 5.1396 (1.1); 5.1192 (2.1); 5.0986 (1.1); 3.9517 (16.0); 1.5705 (3.0); 1.2629 (1.7); 1.2167 (0.6); 1.2043 (0.9); 1.1919 (0.7); 1.1843 (0.9); 1.1711 (0.6); 0.8985 (0.8); 0.8819 (1.9); 0.8643 (0.9); 0.5195 (0.7); 0.5097 (0.8); 0.4943 (0.7); 0.4055 (0.6); 0.3937 (0.7); 0.3850 (0.8); 0.3729 (1.0); 0.3613 (0.8); 0.3526 (0.8); 0.3383 (1.0); 0.3260 (1.0); 0.3137 (0.7); 0.0577 (0.8); 0.0455 (0.9); 0.0336 (1.0); 0.0211 15 (1.0); -0.0002 (28.1) I.2-73: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6499 (2.8); 8.6439 (3.2); 8.5959 (3.2); 8.5900 (2.5); 8.3896 (2.7); 8.2704 (5.1); 8.2018 (1.4); 8.1820 (1.6); 8.0253 (2.2); 7.9910 (1.3); 7.9716 (1.5); 7.6636 (1.3); 7.6443 (2.4); 7.6250 (1.2); 7.3978 (0.9); 7.3778 (0.9); 7.2621 (19.7); 5.1582 (1.0); 5.1374 (2.0); 5.1168 20 (1.1); 3.9589 (16.0); 1.5750 (11.2); 1.3031 (1.3); 1.2638 (6.4); 1.2281 (1.3); 1.2158 (0.8); 1.2081 (0.5); 0.8985 (2.9); 0.8819 (7.4); 0.8643 (3.4); 0.5630 (0.6); 0.5524 (0.8); 0.5374 (0.7); 0.4365 (0.6); 0.4249 (0.6); 0.4161 (0.8); 0.4040 (0.9); 0.3892 (0.6); 0.3835 (0.7); 0.3765 (0.8); 0.3663 (0.9); 0.3538 (1.0); 0.3415 (0.7); 0.0712 (0.7); 0.0588 (0.8); 0.0466 (0.9); 0.0342 (0.7); -0.0002 (23.8); -0.0082 (1.4) 25 I.2-74: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6250 (2.8); 8.6191 (3.3); 8.5776 (3.2); 8.5717 (2.4); 8.3482 (2.6); 8.1952 (1.4); 8.1755 (1.5); 7.9926 (1.2); 7.9731 (1.4); 7.9399 (2.9); 7.9349 (2.8); 7.6828 (1.4); 7.6776 (1.5); 7.6733 (1.5); 7.6620 (2.1); 7.6546 (2.8); 7.6344 (1.2); 7.5512 (3.1); 7.5304 (2.3); 7.2619 (26.8); 7.1487 (0.9); 7.1258 (1.0); 5.5514 (1.0); 5.5328 (1.3); 5.5287 (1.2); 5.5100 (1.0); 3.9560 (16.0); 2.0232 (0.5); 2.0060 (0.9); 1.9888 (0.9); 1.9713 (0.6); 1.5629 (11.7); 0.8795 (6.2); 0.8627 (6.0); 0.6435 30 (5.8); 0.6267 (5.7); -0.0002 (33.5); -0.0084 (1.8) BCS241005-Ausland STR 217 I.2-75: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6630 (2.5); 8.6570 (3.1); 8.6018 (2.6); 8.5958 (2.2); 8.3421 (1.1); 8.3380 (2.0); 8.3342 (1.1); 8.2682 (3.3); 8.2163 (0.7); 8.2130 (1.0); 8.2093 (0.7); 8.1968 (0.8); 8.1932 (1.1); 8.1898 (0.8); 8.0209 (1.4); 7.9586 (0.7); 7.9544 (0.9); 7.9512 (0.7); 7.9394 (0.8); 7.9350 (1.0); 7.9320 (0.8); 7.6807 (1.1); 7.6613 (1.9); 7.6419 (0.9); 7.4019 (0.6); 7.3812 (0.6); 7.2632 (8.2); 5 5.6316 (0.7); 5.6152 (0.6); 5.6115 (0.5); 5.3019 (16.0); 3.9575 (16.0); 1.8822 (0.7); 1.8665 (0.6); 1.8634 (0.6); 1.8480 (0.5); 1.8430 (0.7); 1.8243 (0.9); 1.8059 (0.7); 1.2557 (0.6); 0.8154 (2.4); 0.7969 (5.4); 0.7783 (2.3); -0.0002 (11.0) I.2-76: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6499 (2.5); 8.6438 (3.0); 8.5937 (2.7); 8.5876 (2.2); 8.3247 10 (1.1); 8.3206 (2.1); 8.3163 (1.2); 8.2042 (0.8); 8.2011 (1.1); 8.1973 (0.7); 8.1847 (0.9); 8.1815 (1.2); 8.1777 (0.8); 8.1658 (0.7); 8.1614 (0.7); 7.9520 (0.7); 7.9488 (1.0); 7.9446 (0.7); 7.9328 (0.9); 7.9296 (1.1); 7.9255 (0.8); 7.8819 (5.7); 7.8775 (6.1); 7.8013 (1.7); 7.7970 (2.8); 7.7926 (1.3); 7.6674 (1.2); 7.6480 (2.0); 7.6287 (1.0); 7.2636 (10.8); 7.2403 (0.7); 5.5666 (0.7); 5.5504 (0.7); 5.3021 (5.2); 3.9526 (16.0); 1.8452 (0.8); 1.8294 (0.6); 1.8266 (0.7); 1.8110 (0.6); 1.8028 (0.7); 1.7842 (1.0); 1.7659 (0.7); 15 1.7495 (0.5); 0.7911 (2.6); 0.7727 (5.6); 0.7541 (2.4); -0.0002 (3.1) I.2-77: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6422 (2.7); 8.6363 (3.2); 8.5938 (3.2); 8.5879 (2.5); 8.3194 (2.7); 8.2016 (1.4); 8.1821 (1.5); 7.9361 (1.3); 7.9168 (1.5); 7.8667 (2.0); 7.8632 (3.0); 7.6672 (1.4); 7.6478 (2.5); 7.6279 (2.7); 7.5304 (2.0); 7.2632 (7.5); 7.2132 (1.0); 7.1926 (1.0); 5.5865 (1.0); 5.5703 20 (1.0); 5.5509 (0.5); 5.3018 (7.8); 3.9525 (16.0); 1.8654 (0.5); 1.8470 (0.9); 1.8305 (0.8); 1.8128 (0.7); 1.7923 (0.8); 1.7736 (1.1); 1.7556 (0.9); 1.7388 (0.6); 1.6098 (2.2); 1.2634 (1.0); 0.8818 (1.2); 0.8641 (0.5); 0.7891 (3.2); 0.7706 (6.6); 0.7521 (3.0); -0.0002 (9.3); -0.0077 (0.6) I.2-78: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6288 (2.7); 8.6230 (3.4); 8.5910 (3.4); 8.5852 (2.6); 8.3438 25 (2.9); 8.1957 (1.6); 8.1765 (1.7); 8.0279 (3.3); 7.9779 (1.5); 7.9589 (1.7); 7.8491 (3.0); 7.7630 (3.1); 7.6717 (1.4); 7.6525 (2.6); 7.6331 (1.3); 7.2617 (26.8); 7.0974 (1.2); 7.0739 (1.2); 5.5251 (1.2); 5.5033 (1.5); 5.4834 (1.2); 3.9574 (16.0); 2.0302 (0.6); 2.0126 (1.1); 1.9948 (1.1); 1.9780 (0.7); 1.5599 (10.8); 1.3032 (0.6); 1.2632 (2.5); 0.8852 (7.8); 0.8684 (7.1); 0.6369 (6.5); 0.6200 (6.3); -0.0002 (33.7) 30 I.2-79: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6475 (2.9); 8.6415 (3.3); 8.6007 (3.2); 8.5948 (2.5); 8.3689 (1.8); 8.3649 (2.7); 8.3610 (1.5); 8.2794 (4.8); 8.2102 (1.4); 8.1905 (1.5); 8.0329 (2.1); 7.9861 (1.3); 7.9702 (1.2); 7.9667 (1.4); 7.6873 (1.3); 7.6680 (2.3); 7.6486 (1.1); 7.2861 (0.9); 7.2639 (6.9); 5.5950 (1.0); 5.5758 (1.4); 5.5727 (1.2); 5.5533 (1.0); 5.3017 (5.8); 3.9630 (16.0); 2.0715 (0.5); 2.0543 (0.9); 2.0369 (0.9); 2.0195 (0.6); 1.6427 (2.5); 1.2637 (2.3); 0.9117 (6.1); 0.8949 (6.7); 0.8817 (3.2); 0.8640 35 (1.4); 0.6627 (5.8); 0.6458 (5.7); -0.0002 (7.4) BCS241005-Ausland STR 218 I.2-80: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6857 (2.7); 8.6797 (3.2); 8.6365 (3.2); 8.6305 (2.4); 8.3149 (2.6); 8.2072 (1.5); 8.1880 (1.5); 7.8804 (1.4); 7.8609 (1.8); 7.8481 (3.0); 7.6538 (1.4); 7.6347 (2.5); 7.6061 (2.2); 7.5245 (2.2); 7.4904 (1.1); 7.4704 (1.1); 7.2618 (51.8); 6.0650 (0.7); 6.0480 (1.4); 6.0294 (1.0); 5.9941 (0.8); 5.9778 (0.5); 5.9691 (0.8); 5.9523 (1.2); 5.9355 (0.6); 5.9265 (0.8); 5.9106 (0.6); 5 5.2865 (1.9); 5.2615 (1.7); 5.1029 (1.8); 5.0604 (1.8); 3.9492 (16.0); 1.5595 (9.5); 0.0692 (1.0); -0.0002 (63.2); -0.0081 (3.3) I.2-81: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6342 (2.8); 8.6283 (3.4); 8.5897 (3.2); 8.5838 (2.5); 8.3528 (1.7); 8.3490 (2.6); 8.3449 (1.5); 8.2000 (1.4); 8.1805 (1.5); 7.9798 (1.2); 7.9638 (1.2); 7.9604 (1.4); 10 7.7355 (1.9); 7.7317 (2.9); 7.7277 (1.7); 7.6764 (1.3); 7.6570 (2.4); 7.6377 (1.1); 7.6026 (2.0); 7.3892 (1.9); 7.2630 (8.9); 7.1695 (0.9); 7.1469 (1.0); 5.5532 (1.0); 5.5344 (1.3); 5.5306 (1.2); 5.5119 (1.0); 5.3018 (2.5); 3.9583 (16.0); 2.0328 (0.5); 2.0158 (0.9); 1.9987 (0.9); 1.9812 (0.6); 1.5999 (3.6); 1.2637 (1.8); 0.8981 (1.0); 0.8851 (6.9); 0.8683 (6.4); 0.6496 (5.8); 0.6327 (5.7); -0.0002 (11.2); -0.0083 (0.6) 15 I.2-82: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7183 (2.7); 8.7123 (2.9); 8.6442 (3.0); 8.6383 (2.5); 8.5477 (2.0); 8.3352 (2.7); 8.2645 (5.0); 8.2204 (1.4); 8.2009 (1.6); 8.1209 (0.9); 8.0135 (2.2); 7.9078 (1.3); 7.8885 (1.5); 7.7781 (1.0); 7.7585 (1.0); 7.6710 (1.3); 7.6515 (2.3); 7.6323 (1.1); 7.2620 (21.0); 6.1251 (0.7); 6.1073 (1.3); 6.0891 (1.0); 6.0473 (0.7); 6.0220 (0.8); 6.0053 (1.2); 5.9888 (0.6); 5.9794 (0.8); 5.9634 (0.6); 5.3268 (1.9); 5.3019 (5.8); 5.1387 (1.8); 5.0958 (1.6); 3.9537 (16.0); 3.9326 (0.6); 2.0119 20 (1.7); 1.2553 (0.5); -0.0002 (25.8); -0.0083 (1.7) I.2-83: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6989 (2.7); 8.6930 (3.1); 8.6439 (3.2); 8.6380 (2.5); 8.3283 (2.8); 8.2453 (5.6); 8.2167 (1.7); 8.1970 (1.7); 8.0173 (2.4); 7.8924 (1.4); 7.8731 (1.6); 7.6652 (1.5); 7.6458 (2.6); 7.6268 (2.1); 7.6093 (1.1); 7.2625 (9.9); 6.1098 (0.8); 6.0924 (1.5); 6.0741 (1.0); 6.0259 25 (0.8); 6.0096 (0.5); 6.0009 (0.8); 5.9839 (1.3); 5.9673 (0.7); 5.9580 (0.8); 5.9419 (0.6); 5.3127 (2.2); 5.3017 (4.0); 5.2877 (2.0); 5.1281 (2.0); 5.0856 (1.8); 3.9537 (16.0); 1.2555 (0.9); -0.0002 (12.3) I.2-84: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6424 (2.8); 8.6365 (3.2); 8.5931 (3.2); 8.5873 (2.5); 8.3191 (2.9); 8.2019 (1.6); 8.1826 (1.7); 7.9352 (1.4); 7.9158 (1.6); 7.7165 (3.1); 7.6672 (1.5); 7.6479 (2.5); 30 7.6286 (1.2); 7.5806 (2.4); 7.3794 (2.3); 7.2622 (15.3); 7.2196 (1.2); 7.1979 (1.2); 5.6086 (0.6); 5.5902 (1.2); 5.5729 (1.1); 5.5542 (0.6); 5.3019 (3.8); 3.9526 (16.0); 1.8658 (0.6); 1.8472 (1.0); 1.8293 (1.0); 1.8133 (0.8); 1.7893 (0.8); 1.7709 (1.2); 1.7530 (1.0); 1.7361 (0.7); 1.5755 (5.2); 0.7887 (3.5); 0.7703 (6.9); 0.7517 (3.1); -0.0002 (18.8) 35 BCS241005-Ausland STR 219 I.2-85: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6424 (2.6); 8.6365 (3.1); 8.5934 (3.0); 8.5874 (2.4); 8.3229 (1.6); 8.3192 (2.5); 8.3150 (1.5); 8.2018 (1.3); 8.1854 (1.1); 8.1823 (1.4); 7.9353 (1.2); 7.9194 (1.1); 7.9160 (1.3); 7.7205 (1.8); 7.7167 (2.8); 7.7127 (1.7); 7.6677 (1.3); 7.6483 (2.3); 7.6290 (1.1); 7.5807 (1.9); 7.3801 (1.8); 7.2623 (16.1); 7.2193 (0.9); 7.1979 (0.9); 5.5899 (0.9); 5.5737 (0.9); 5.3020 (5.3); 5 3.9527 (16.0); 2.0111 (4.0); 1.8474 (0.8); 1.8317 (0.7); 1.8131 (0.6); 1.7895 (0.7); 1.7711 (1.0); 1.7529 (0.8); 1.7364 (0.6); 1.5772 (5.2); 0.7889 (2.9); 0.7704 (6.2); 0.7519 (2.8); -0.0002 (19.7); -0.0082 (1.1) I.2-86: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6300 (2.7); 8.6241 (3.4); 8.5912 (3.2); 8.5853 (2.4); 8.3444 (2.7); 8.1968 (1.4); 8.1771 (1.5); 7.9762 (1.2); 7.9568 (1.4); 7.8906 (6.3); 7.8863 (6.5); 7.8158 (2.1); 10 7.8115 (3.1); 7.8072 (1.5); 7.6724 (1.3); 7.6531 (2.4); 7.6337 (1.1); 7.2620 (21.0); 7.1108 (0.9); 7.0876 (1.0); 5.5289 (1.0); 5.5098 (1.4); 5.4871 (1.0); 3.9578 (16.0); 2.0476 (0.8); 2.0313 (0.6); 2.0137 (0.9); 1.9965 (0.9); 1.9794 (0.6); 1.5660 (8.2); 1.2613 (1.9); 0.8980 (1.1); 0.8855 (6.9); 0.8687 (6.4); 0.6391 (5.8); 0.6222 (5.8); -0.0002 (26.2); -0.0083 (1.5) 15 I.2-87: 1H-NMR (400.6 MHz, d6-DMSO): δ= 9.1846 (2.1); 9.1682 (2.1); 8.6843 (3.5); 8.6783 (5.3); 8.6639 (5.6); 8.6578 (3.3); 8.1754 (4.0); 8.0422 (2.1); 8.0226 (2.5); 7.9786 (16.0); 7.9270 (2.0); 7.9076 (2.2); 7.6558 (1.8); 7.6365 (3.2); 7.6172 (1.5); 5.2962 (1.2); 5.2796 (1.9); 5.2627 (1.3); 3.3370 (0.6); 2.5097 (43.0); 2.5055 (53.0); 2.5012 (38.8); 1.4834 (7.0); 1.4663 (7.0); -0.0002 (26.0); -0.0082 (1.8) 20 I.2-88: 1H-NMR (400.6 MHz, d6-DMSO): δ= 8.7130 (0.7); 8.7071 (1.0); 8.6915 (1.0); 8.6856 (0.6); 8.1607 (0.8); 8.0230 (0.8); 8.0182 (0.8); 7.8501 (0.6); 7.8294 (0.8); 7.6772 (0.8); 3.8401 (3.9); 3.3342 (16.0); 2.5061 (27.9); 2.5025 (34.5); -0.0002 (5.0) I.2-89: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1234 (1.0); 9.3163 (5.7); 9.2990 (6.0); 8.7891 (0.6); 25 8.7060 (8.3); 8.7001 (14.0); 8.6884 (14.6); 8.6824 (8.1); 8.1762 (10.4); 8.0594 (5.8); 8.0430 (15.6); 8.0388 (16.0); 7.9231 (5.4); 7.9042 (6.2); 7.8485 (8.7); 7.8275 (11.4); 7.6875 (6.7); 7.6823 (7.0); 7.6775 (6.1); 7.6668 (6.1); 7.6585 (10.1); 7.6388 (4.4); 7.5080 (0.5); 6.1977 (1.9); 6.1807 (2.2); 6.1722 (2.4); 6.1549 (4.5); 6.1382 (2.6); 6.1289 (2.4); 6.1124 (2.5); 5.8538 (3.1); 5.8371 (5.6); 5.8203 (3.0); 5.2461 (6.3); 5.2206 (6.0); 5.0070 (6.0); 4.9641 (5.7); 4.6306 (0.9); 3.6330 (3.1); 2.6717 (2.8); 2.5069 (342.8); 30 2.5030 (428.8); 2.3305 (4.5); 0.1451 (0.9); 0.0295 (1.0); -0.0002 (157.6); -0.1493 (1.1) BCS241005-Ausland STR 220 I.2-90: 1H-NMR (400.6 MHz, d6-DMSO): δ= 9.0978 (1.2); 9.0812 (1.2); 8.6765 (2.0); 8.6704 (3.5); 8.6584 (3.6); 8.6524 (2.0); 8.1999 (2.4); 8.0445 (1.2); 8.0251 (1.4); 7.9707 (1.1); 7.9513 (1.3); 7.6617 (1.2); 7.6422 (3.7); 7.6385 (2.9); 7.6232 (1.1); 7.5364 (1.8); 7.2884 (1.8); 5.3379 (0.7); 5.3211 (1.1); 5.3038 (0.7); 3.3356 (16.0); 2.5079 (50.2); 2.5036 (63.7); 2.4992 (45.5); 1.9904 (1.7); 1.9105 (1.3); 5 1.4898 (4.2); 1.4725 (4.2); 1.4160 (0.8); 1.3962 (10.9); 1.3556 (1.7); 1.1927 (0.5); 1.1811 (0.6); 1.1749 (1.2); 1.1696 (1.0); 1.1571 (0.5); 0.9434 (1.0); 0.9300 (2.7); 0.8315 (1.1); 0.8217 (3.3); 0.8164 (2.8); 0.8082 (0.8); -0.0002 (12.2); -0.0084 (0.7) I.2-91: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6449 (2.7); 8.6389 (3.2); 8.5926 (3.1); 8.5866 (2.5); 8.2956 10 (2.7); 8.1998 (1.4); 8.1803 (1.5); 8.1097 (2.9); 7.8883 (1.3); 7.8691 (1.5); 7.7819 (2.1); 7.7646 (2.1); 7.6606 (1.4); 7.6412 (2.4); 7.6219 (1.1); 7.4613 (1.0); 7.4421 (1.1); 7.2643 (10.6); 6.3418 (0.7); 5.6513 (0.9); 5.6338 (1.2); 5.6157 (0.9); 5.3022 (8.2); 4.0813 (0.5); 4.0646 (1.1); 4.0477 (0.6); 3.9461 (16.0); 3.0441 (7.2); 3.0320 (7.2); 2.0479 (4.3); 1.6468 (6.0); 1.6277 (0.5); 1.6100 (0.6); 1.4661 (6.0); 1.4494 (6.0); 1.2601 (0.8); 1.2447 (0.5); 0.9539 (0.9); 0.9355 (1.7); 0.9171 (0.8); -0.0002 (11.7); -0.0081 (0.7) 15 I.2-92: 1H-NMR (400 MHz, CDCl3): δ= 8.6419 (2.6); 8.6360 (3.2); 8.5973 (3.1); 8.5913 (2.4); 8.2995 (2.5); 8.2007 (1.3); 8.1810 (1.4); 7.9173 (1.2); 7.8979 (1.4); 7.6621 (1.2); 7.6426 (2.2); 7.6233 (1.1); 7.5986 (1.8); 7.5949 (2.9); 7.5911 (1.7); 7.4012 (1.8); 7.2829 (0.9); 7.2617 (35.4); 7.2172 (2.0); 5.6529 (0.8); 5.6362 (1.1); 5.6171 (0.8); 3.9453 (16.0); 1.5600 (13.0); 1.4631 (5.9); 1.4464 (6.1); 1.4286 (12.1);20 0.9222 (0.9); 0.9059 (3.1); 0.8958 (1.5); 0.8334 (1.9); 0.8235 (3.5); 0.8068 (1.1); -0.0002 (38.0); - 0.0084 (2.0) I.2-93: 1H-NMR (400 MHz, CDCl3): δ= 8.6849 (0.6); 8.6789 (0.8); 8.6625 (0.8); 8.3179 (0.6); 8.2101 (0.5); 3.3326 (16.0); 2.8002 (1.2); 2.7890 (1.2); 2.5108 (21.1); 2.5067 (39.4); 2.5023 (50.0); 2.4979 25 (35.8); 2.4937 (17.6); 1.4993 (0.9); 1.4823 (0.9); -0.0002 (8.9); -0.0081 (0.5) I.2-94: 1H-NMR (400 MHz, CDCl3): δ= 8.6838 (2.2); 8.6783 (2.5); 8.6349 (2.7); 8.6292 (2.1); 8.3151 (2.7); 8.2069 (1.5); 8.1874 (1.6); 7.8798 (1.3); 7.8602 (1.5); 7.7013 (2.9); 7.6533 (1.4); 7.6340 (2.4); 7.6147 (1.2); 7.5632 (2.2); 7.4943 (1.0); 7.4755 (1.1); 7.3740 (2.1); 7.2622 (16.0); 6.0653 (0.8); 6.0481 30 (1.4); 6.0300 (1.0); 5.9913 (0.8); 5.9752 (0.5); 5.9662 (0.8); 5.9496 (1.2); 5.9329 (0.6); 5.9238 (0.8); 5.9076 (0.6); 5.3019 (2.3); 5.2834 (2.0); 5.2586 (1.8); 5.1015 (1.9); 5.0593 (1.8); 3.9492 (16.0); 1.5718 (14.6); -0.0002 (18.1); -0.0083 (0.8) BCS241005-Ausland STR 221 I.2-95: 1H-NMR (400 MHz, CDCl3): δ= 8.6839 (2.1); 8.6783 (2.4); 8.6349 (2.6); 8.6292 (2.1); 8.3153 (2.7); 8.2067 (1.4); 8.1872 (1.5); 7.8800 (1.3); 7.8607 (1.5); 7.7016 (2.9); 7.6535 (1.4); 7.6341 (2.4); 7.6147 (1.1); 7.5635 (2.2); 7.4971 (1.0); 7.4777 (1.0); 7.3744 (2.0); 7.2626 (11.2); 6.0656 (0.7); 6.0485 (1.4); 6.0301 (1.0); 5.9915 (0.7); 5.9665 (0.8); 5.9497 (1.2); 5.9332 (0.6); 5.9239 (0.8); 5.9079 (0.6); 5 5.3018 (5.0); 5.2835 (2.0); 5.2584 (1.8); 5.1020 (1.9); 5.0596 (1.7); 3.9491 (16.0); 1.5825 (10.0); - 0.0002 (12.6) I.2-96: 1H-NMR (400 MHz, CDCl3): δ= 8.6331 (2.8); 8.6271 (3.3); 8.5872 (3.2); 8.5812 (2.4); 8.3740 (1.7); 8.3700 (2.6); 8.1900 (1.3); 8.1704 (1.5); 7.9800 (1.2); 7.9608 (1.4); 7.8813 (6.2); 7.8770 (6.3); 10 7.8071 (2.0); 7.8029 (3.0); 7.7986 (1.5); 7.6494 (1.3); 7.6300 (2.3); 7.6106 (1.1); 7.2623 (18.2); 7.2328 (1.0); 7.2123 (0.9); 5.1120 (1.0); 5.0914 (1.9); 5.0707 (1.0); 3.9537 (16.0); 2.1746 (0.8); 1.5733 (15.0); 1.2640 (1.5); 1.2220 (0.5); 1.2098 (0.9); 1.2015 (0.6); 1.1978 (0.6); 1.1891 (0.8); 0.8984 (0.7); 0.8818 (1.9); 0.8642 (0.8); 0.5284 (0.6); 0.5175 (0.7); 0.5081 (0.6); 0.5022 (0.6); 0.4109 (0.5); 0.3988 (0.6); 0.3903 (0.7); 0.3781 (0.8); 0.3609 (0.6); 0.3477 (0.7); 0.3378 (0.8); 0.3258 (0.9); 0.3134 (0.6); 0.0575 15 (0.7); 0.0454 (0.8); 0.0337 (0.8); 0.0205 (0.7); -0.0002 (20.8); -0.0084 (1.1) I.2-97: 1H-NMR (400 MHz, CDCl3): δ= 8.6337 (2.7); 8.6282 (3.3); 8.5868 (3.3); 8.5811 (2.6); 8.3698 (3.0); 8.1892 (1.6); 8.1697 (1.8); 8.0184 (3.3); 7.9845 (1.5); 7.9652 (1.7); 7.8391 (3.0); 7.7565 (3.1); 7.6487 (1.5); 7.6293 (2.6); 7.6099 (1.3); 7.2623 (16.0); 7.2379 (1.3); 7.2180 (1.2); 5.1035 (1.2); 5.0829 20 (2.3); 5.0622 (1.2); 3.9533 (16.0); 1.5770 (2.2); 1.2632 (1.9); 1.2300 (0.5); 1.2226 (0.6); 1.2096 (1.0); 1.1983 (0.8); 1.1893 (1.0); 1.1770 (0.6); 0.8978 (0.8); 0.8815 (1.9); 0.8641 (0.9); 0.5296 (0.7); 0.5180 (0.9); 0.5040 (0.8); 0.4104 (0.7); 0.3979 (0.7); 0.3898 (0.9); 0.3771 (1.0); 0.3663 (0.5); 0.3584 (0.9); 0.3471 (0.9); 0.3364 (1.0); 0.3240 (1.2); 0.3121 (0.8); 0.0548 (0.9); 0.0425 (1.0); 0.0304 (1.2); 0.0182 (1.0); -0.0002 (18.4) 25 I.2-98: 1H-NMR (400 MHz, CDCl3): δ= 8.6398 (2.8); 8.6339 (3.3); 8.5880 (3.2); 8.5820 (2.5); 8.3752 (2.7); 8.1924 (1.4); 8.1728 (1.5); 7.9845 (1.3); 7.9654 (1.5); 7.8782 (2.0); 7.8748 (3.0); 7.8713 (1.8); 7.6525 (1.3); 7.6329 (4.1); 7.6138 (1.3); 7.5306 (2.0); 7.2907 (0.9); 7.2630 (9.5); 5.3017 (6.3); 5.1268 (1.0); 5.1061 (2.0); 5.0855 (1.1); 3.9539 (16.0); 1.6072 (0.6); 1.2632 (1.3); 1.2269 (0.6); 1.2144 (0.9); 30 1.2026 (0.6); 1.1939 (0.9); 1.1815 (0.5); 0.8981 (0.6); 0.8817 (1.5); 0.8640 (0.7); 0.5345 (0.6); 0.5242 (0.8); 0.5093 (0.7); 0.4143 (0.5); 0.4073 (0.5); 0.4022 (0.6); 0.3940 (0.7); 0.3816 (0.9); 0.3711 (0.5); 0.3660 (0.6); 0.3613 (0.6); 0.3533 (0.8); 0.3434 (0.9); 0.3313 (1.0); 0.3183 (0.7); 0.0559 (0.7); 0.0437 (0.8); 0.0309 (0.8); 0.0195 (0.7); -0.0002 (11.1); -0.0084 (0.8) 35 BCS241005-Ausland STR 222 I.2-99: 1H-NMR (400 MHz, CDCl3): δ= 8.6388 (2.8); 8.6329 (3.2); 8.5872 (3.3); 8.5812 (2.6); 8.3755 (2.8); 8.1932 (1.5); 8.1736 (1.6); 7.9831 (1.4); 7.9639 (1.6); 7.7281 (3.0); 7.6532 (1.4); 7.6338 (2.5); 7.6144 (1.3); 7.5869 (2.3); 7.3804 (2.1); 7.2876 (1.1); 7.2632 (9.6); 5.3019 (2.1); 5.1350 (1.1); 5.1144 (2.2); 5.0938 (1.1); 3.9542 (16.0); 1.6272 (1.6); 1.2636 (0.6); 1.2251 (0.6); 1.2125 (1.0); 1.2002 (0.7); 5 1.1920 (0.9); 1.1798 (0.6); 0.8816 (0.7); 0.5319 (0.7); 0.5217 (0.8); 0.5067 (0.7); 0.4139 (0.6); 0.4013 (0.7); 0.3925 (0.9); 0.3805 (1.0); 0.3664 (0.7); 0.3535 (0.8); 0.3436 (1.0); 0.3311 (1.1); 0.3183 (0.8); 0.0566 (0.8); 0.0446 (0.9); 0.0317 (1.0); 0.0199 (0.8); -0.0002 (10.5) I.2-100: 1H-NMR(400 MHz, d6-DMSO): 10 δ= 8.7140 (0.6); 8.7080 (1.0); 8.6919 (1.1); 8.6858 (0.7); 8.1843 (0.8); 8.1793 (0.8); 8.1637 (0.7); 7.7849 (0.5); 7.6982 (1.2); 7.6780 (0.9); 3.8415 (4.0); 3.3326 (16.0); 2.5248 (0.8); 2.5112 (20.0); 2.5069 (38.7); 2.5025 (50.2); 2.4980 (37.4); 2.4938 (20.1); 0.0077 (1.3); -0.0002 (23.7); -0.0084 (2.0) I.2-105: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6401 (2.6); 8.6341 (3.2); 8.5947 (3.1); 8.5887 (2.4); 8.2960 (2.7); 8.1993 (1.4); 8.1796 (1.5); 7.9101 (1.2); 7.8907 (1.5); 7.6599 (1.3); 7.6405 (2.4); 7.6211 (1.1); 7.4354 (2.8); 7.3850 (2.0); 7.2828 (1.0); 7.2617 (24.8); 7.0213 (2.0); 5.6466 (0.9); 5.6280 (1.2); 5.6106 (0.9); 3.9443 (16.0); 1.9823 (0.6); 1.9739 (0.7); 1.9615 (1.2); 1.9491 (0.7); 1.9405 (0.6); 1.5621 (9.7); 1.4560 (6.3); 1.4393 (6.2); 1.0806 (0.7); 1.0683 (2.0); 1.0639 (2.0); 1.0474 (2.1); 1.0429 (1.8); 1.0314 (0.8); 0.7795 (0.9); 0.7675 (2.7); 0.7635 (2.2); 0.7554 (2.1); 0.7511 (2.5); 0.7387 (0.7); -0.0002 (29.9); - 0.0084 (1.4) I.2-106: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6620 (7.4); 8.6559 (8.9); 8.6119 (8.5); 8.6059 (6.8); 8.3657 (7.1); 8.2415 (3.7); 8.2218 (4.0); 7.9751 (3.3); 7.9556 (3.9); 7.6959 (3.4); 7.6764 (6.1); 7.6568 (2.9); 7.5190 (0.8); 7.4471 (7.6); 7.3953 (5.6); 7.3780 (3.3); 7.3576 (3.1); 7.2604 (116.1); 7.0171 (5.2); 5.6813 (2.2); 5.6648 (3.0); 5.6456 (2.3); 5.6297 (0.7); 3.7681 (1.1); 3.7518 (2.3); 2.1236 (0.9); 1.9838 (0.9); 1.9715 (1.7); 1.9630 (1.9); 1.9504 (3.3); 1.9379 (2.1); 1.9294 (2.0); 1.9163 (1.1); 1.8721 (1.3); 1.8559 (2.9); 1.8393 (1.3); 1.4840 (15.8); 1.4672 (16.0); 1.4322 (2.6); 1.2425 (0.9); 1.0651 (2.0); 1.0528 (5.2); 1.0484 (5.5); 1.0320 (5.8); 1.0274 (5.2); 1.0158 (2.5); 0.7716 (2.2); 0.7595 (7.0); 0.7556 (5.7); 0.7470 (5.8); 0.7430 (7.0); 0.7309 (2.1); 0.1464 (0.6); -0.0002 (142.2); -0.0083 (8.4); -0.1491 (0.8) I.2-107: 1H-NMR(300.0 MHz, d6-DMSO): δ= 12.7329 (1.8); 9.1049 (1.7); 9.0831 (1.8); 8.6133 (13.7); 8.1010 (3.6); 8.0946 (3.7); 7.9571 (3.4); 7.9494 (3.9); 7.8860 (1.8); 7.8782 (1.5); 7.8573 (2.0); 7.8496 (1.7); 7.8163 (1.4); 7.8097 (1.3); 7.7882 (2.5); 7.7816 (2.5); 7.7247 (4.5); 7.6967 (2.4); 7.2909 (2.9); 7.2619 (2.6); 5.3648 (1.0); 5.3424 (1.6); 5.3198 (1.1); 3.8950 (16.0); 3.8583 (0.7); 3.3327 (8.2); 2.5048 (9.8); 2.0775 (8.5); 1.4653 (6.0); 1.4424 (5.8); -0.0002 (3.1) BCS241005-Ausland STR 223 I.2-108: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.0855 (1.4); 9.0636 (1.5); 8.6300 (1.5); 8.6217 (6.5); 8.6185 (6.4); 8.6101 (1.6); 8.0856 (3.1); 8.0792 (3.2); 7.9424 (2.5); 7.9350 (3.7); 7.9190 (1.8); 7.9108 (1.0); 7.8905 (1.8); 7.8826 (1.3); 7.8060 (1.2); 7.7993 (1.0); 7.7781 (2.2); 7.7715 (2.2); 7.7257 (3.9); 7.6977 (2.0); 7.3118 (2.4); 7.2831 (2.3); 5.3497 (0.9); 5.3271 (1.4); 5.3045 (0.9); 3.8947 (14.7); 3.8608 (0.8); 3.8157 (0.8); 3.7996 (0.4); 3.7666 (16.0); 3.3182 (21.0); 3.2948 (0.7); 2.5077 (25.0); 2.5019 (33.4); 2.4961 (24.1); 1.4673 (5.3); 1.4444 (5.2); -0.0002 (13.8) I.2-109: 1H-NMR(300.0 MHz, d6-DMSO): δ= 12.7407 (3.8); 9.2148 (1.5); 9.1930 (1.5); 8.6185 (16.0); 7.9972 (2.2); 7.9918 (4.0); 7.9865 (2.3); 7.9485 (3.3); 7.9407 (3.9); 7.8788 (1.7); 7.8709 (1.4); 7.8502 (1.9); 7.8422 (1.6); 7.7595 (4.7); 7.7567 (6.0); 7.7546 (5.7); 7.2880 (2.8); 7.2589 (2.6); 5.3741 (0.9); 5.3517 (1.4); 5.3292 (1.0); 3.8905 (15.8); 3.3230 (30.0); 2.5136 (14.0); 2.5077 (24.7); 2.5023 (31.4); 2.4971 (20.0); 1.4766 (5.4); 1.4537 (5.3); 0.0108 (0.6); -0.0002 (16.2); -0.0112 (0.5) I.2-110: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.1967 (1.4); 9.1746 (1.5); 8.6387 (1.3); 8.6299 (7.3); 8.6281 (7.3); 8.6194 (1.4); 7.9823 (2.0); 7.9776 (3.2); 7.9726 (2.1); 7.9366 (2.4); 7.9291 (3.7); 7.9138 (1.9); 7.9060 (1.0); 7.8853 (1.7); 7.8775 (1.3); 7.7507 (3.9); 7.3097 (2.5); 7.2810 (2.3); 5.3642 (0.9); 5.3418 (1.4); 5.3192 (0.9); 3.8912 (14.7); 3.7626 (16.0); 3.3183 (6.6); 2.5082 (18.0); 2.5023 (23.9); 2.4965 (17.1); 2.0752 (0.6); 1.4826 (5.2); 1.4598 (5.2); 0.0105 (0.4); -0.0001 (9.8); -0.0110 (0.4) I.2-111: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6377 (1.5); 8.6318 (1.9); 8.5942 (1.8); 8.5883 (1.4); 8.3154 (1.5); 8.1992 (0.8); 8.1794 (0.9); 7.9334 (0.7); 7.9145 (0.8); 7.8729 (3.6); 7.8687 (3.7); 7.8069 (1.2); 7.8028 (1.7); 7.7984 (0.9); 7.6644 (0.8); 7.6450 (1.4); 7.6258 (0.7); 7.2618 (25.6); 7.1585 (0.5); 7.1365 (0.6); 5.5713 (0.5); 5.5544 (0.6); 5.3021 (3.8); 3.9523 (9.4); 1.8404 (0.5); 1.7680 (0.6); 1.7502 (0.5); 1.5568 (16.0); 0.7830 (1.8); 0.7644 (3.7); 0.7459 (1.7); -0.0002 (28.2); -0.0082 (1.5) I.2-112: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6422 (2.8); 8.6363 (3.2); 8.5936 (3.3); 8.5877 (2.5); 8.3192 (2.9); 8.2017 (1.6); 8.1821 (1.6); 7.9361 (1.4); 7.9170 (1.6); 7.8636 (3.1); 7.6672 (1.5); 7.6478 (2.6); 7.6277 (3.0); 7.5298 (2.2); 7.2632 (8.2); 7.2149 (1.1); 7.1942 (1.1); 5.6050 (0.6); 5.5865 (1.1); 5.5698 (1.1); 5.5504 (0.5); 5.3018 (5.9); 3.9526 (16.0); 1.8647 (0.6); 1.8469 (1.0); 1.8289 (0.9); 1.8123 (0.8); 1.7922 (0.9); 1.7735 (1.2); 1.7555 (1.0); 1.7386 (0.7); 1.6043 (8.2); 0.7889 (3.4); 0.7704 (6.8); 0.7519 (3.0); -0.0002 (9.2) I.2-113: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6419 (2.3); 8.6364 (2.5); 8.5938 (2.7); 8.5881 (2.1); 8.3193 (2.8); 8.2018 (1.6); 8.1821 (1.6); 7.9362 (1.4); 7.9170 (1.6); 7.8636 (3.1); 7.6672 (1.5); BCS241005-Ausland STR 224 7.6478 (2.6); 7.6278 (3.0); 7.5299 (2.2); 7.2632 (8.3); 7.2148 (1.1); 7.1935 (1.1); 5.6048 (0.6); 5.5863 (1.1); 5.5698 (1.1); 5.5506 (0.5); 5.3018 (6.0); 3.9526 (16.0); 1.8649 (0.6); 1.8470 (1.0); 1.8290 (0.9); 1.8121 (0.8); 1.7924 (0.9); 1.7736 (1.2); 1.7556 (1.0); 1.7386 (0.7); 1.6031 (8.1); 0.7889 (3.5); 0.7704 (6.8); 0.7520 (3.0); -0.0002 (9.4) I.2-114: 1H-NMR(400.2 MHz, d6-DMSO): δ= 9.0105 (2.2); 8.9929 (2.5); 8.7797 (6.8); 8.7735 (8.2); 8.7190 (4.6); 8.7133 (4.7); 7.9827 (7.0); 7.9778 (8.9); 7.9561 (2.9); 7.9354 (2.7); 7.9309 (2.2); 7.8165 (4.5); 7.7609 (3.5); 7.7408 (7.7); 7.6480 (1.0); 7.6275 (1.0); 7.5998 (3.8); 5.1838 (0.4); 5.0935 (1.3); 5.0761 (1.9); 5.0590 (1.2); 5.0414 (0.3); 3.8761 (0.3); 3.8475 (2.9); 3.7182 (16.0); 3.5082 (1.0); 3.3229 (46.2); 2.6756 (0.3); 2.6713 (0.4); 2.6667 (0.4); 2.5111 (23.5); 2.5067 (48.0); 2.5022 (65.3); 2.4977 (47.4); 2.4933 (22.5); 2.3291 (0.4); 1.4853 (16.0); 1.4682 (15.5); 1.2327 (0.3); 0.0079 (1.3); -0.0002 (29.1); -0.0084 (1.2) I.2-115: 1H-NMR(300.1 MHz, d6-DMSO): δ= 13.1836 (2.2); 9.0486 (2.6); 9.0267 (3.2); 8.7651 (7.5); 8.7576 (9.1); 8.7083 (10.9); 8.7003 (9.1); 8.0417 (4.8); 7.9779 (5.7); 7.9729 (5.9); 7.9507 (6.3); 7.9442 (5.5); 7.8564 (9.3); 7.7421 (3.8); 7.7191 (9.1); 7.6428 (6.4); 7.6070 (1.0); 5.1853 (0.6); 5.0612 (1.5); 5.0386 (2.1); 5.0160 (1.5); 3.5105 (0.7); 3.3207 (7.0); 2.5037 (38.8); 1.4763 (16.0); 1.4536 (15.9); 1.2362 (0.3); -0.0002 (43.0) I.2-116: 1H-NMR(400.2 MHz, d6-DMSO): δ= 9.0678 (3.5); 8.7143 (12.7); 8.7086 (15.6); 8.6710 (10.6); 7.9122 (16.0); 7.7562 (15.5); 7.6886 (11.7); 7.6420 (0.4); 7.5388 (0.3); 7.4811 (12.4); 7.4610 (11.3); 6.5306 (0.5); 4.9721 (3.0); 3.8060 (3.5); 3.7430 (3.1); 3.5085 (1.5); 3.3244 (76.6); 3.3022 (3.0); 2.6762 (1.0); 2.6718 (1.4); 2.6674 (1.0); 2.5115 (69.4); 2.5072 (144.3); 2.5027 (198.3); 2.4982 (147.3); 2.4939 (73.8); 2.4264 (0.3); 2.3340 (1.0); 2.3295 (1.4); 2.3248 (1.1); 2.1503 (7.9); 1.4188 (11.4); 1.2337 (0.5); 0.1462 (0.4); 0.0079 (4.0); -0.0002 (93.4); -0.0083 (4.3); -0.1492 (0.4) I.2-117: 1H-NMR(400.2 MHz, d6-DMSO): δ= 8.9602 (1.8); 8.7052 (7.5); 8.6992 (9.0); 8.6614 (5.8); 8.1351 (0.3); 8.0183 (4.2); 7.9047 (2.6); 7.7696 (0.7); 7.7472 (2.2); 7.7257 (6.4); 7.7223 (6.6); 7.7105 (16.0); 7.6896 (4.2); 7.4907 (8.1); 7.4706 (7.2); 4.9513 (1.5); 3.8040 (2.0); 3.5079 (0.4); 3.3249 (18.1); 5 3.3019 (1.2); 2.6763 (0.4); 2.6715 (0.5); 2.6669 (0.4); 2.5115 (26.6); 2.5071 (54.8); 2.5025 (74.8); 2.4980 (55.0); 2.4936 (26.9); 2.3339 (0.5); 2.3294 (0.6); 2.3249 (0.5); 2.1557 (3.3); 2.0759 (1.2); 1.5204 (0.3); 1.5024 (0.4); 1.4064 (6.0); 0.0080 (1.7); -0.0002 (40.6); -0.0084 (1.9) I.2-118: 1H-NMR(300.1 MHz, d6-DMSO): BCS241005-Ausland STR 225 δ= 12.8877 (2.9); 8.9865 (3.5); 8.9658 (3.4); 8.6901 (10.5); 8.6820 (14.6); 8.6522 (11.9); 8.6443 (8.5); 8.0895 (0.4); 8.0418 (10.7); 8.0369 (10.5); 7.9641 (0.7); 7.9228 (5.4); 7.8968 (5.9); 7.8512 (0.9); 7.8205 (0.9); 7.7697 (4.4); 7.7635 (3.9); 7.7417 (10.1); 7.7356 (9.7); 7.7079 (16.0); 7.6801 (6.0); 7.4745 (9.0); 7.4474 (7.8); 6.5217 (0.6); 4.9512 (2.1); 3.3173 (210.0); 2.7272 (1.1); 2.7211 (0.8); 2.5861 (0.4); 2.5070 (132.3); 2.5012 (174.5); 2.4954 (124.4); 2.2761 (1.0); 2.2715 (1.2); 2.2657 (1.1); 2.1563 (7.6); 2.0738 (10.9); 1.4007 (7.4); 1.2659 (0.4); 1.2365 (0.6); 0.1948 (0.4); 0.0103 (2.9); -0.0001 (65.9); -0.1989 (0.4) I.2-119: 1H-NMR(300.1 MHz, d6-DMSO):δ= 13.7184 (0.4); 12.9695 (0.6); 12.8889 (2.1); 12.7378 (0.4); 10.0331 (0.4); 9.0939 (3.4); 9.0718 (3.3); 8.6980 (10.9); 8.6899 (16.0); 8.6612 (12.8); 8.6530 (8.9); 8.1375 (0.4); 8.0133 (0.5); 7.9660 (0.7); 7.9318 (13.2); 7.8918 (6.5); 7.8275 (1.0); 7.7919 (0.9); 7.7458 (10.1); 7.7074 (10.2); 7.6642 (0.4); 7.4966 (0.4); 7.4635 (8.1); 7.4361 (7.2); 6.5205 (1.1); 5.0855 (0.4); 4.9723 (2.2); 4.9545 (2.0); 3.6611 (0.4); 3.3819 (0.4); 3.3179 (281.0); 2.7273 (1.7); 2.7215 (1.3); 2.5973 (0.6); 2.5686 (0.7); 2.5072 (224.0); 2.5015 (291.7); 2.4959 (206.7); 2.2720 (2.0); 2.1507 (8.7); 1.5879 (0.4); 1.4134 (7.1); 1.2402 (0.6); 1.1535 (0.4); 0.1951 (0.5); 0.0103 (4.4); -0.0001 (93.6); -0.0110 (3.3); - 0.1972 (0.6) I.2-120: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6362 (2.6); 8.6303 (3.2); 8.5950 (3.2); 8.5891 (2.4); 8.2478 (1.3); 8.2418 (1.3); 8.2309 (1.3); 8.2250 (1.3); 7.9086 (0.7); 7.9026 (0.8); 7.8976 (0.8); 7.8914 (0.8); 7.8873 (0.8); 7.8813 (0.9); 7.8764 (0.8); 7.8704 (0.7); 7.7040 (1.8); 7.7003 (2.8); 7.6964 (1.7); 7.5586 (2.0); 7.3748 (1.9); 7.3628 (1.4); 7.3412 (1.5); 7.3371 (1.4); 7.3156 (1.2); 7.2831 (0.9); 7.2614 (12.4); 5.6251 (0.9); 5.6078 (1.1); 5.5892 (0.9); 3.9616 (16.0); 1.5746 (9.0); 1.4663 (6.3); 1.4496 (6.3); -0.0002 (13.2) I.2-122: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6377 (1.9); 8.6317 (2.1); 8.5731 (2.0); 8.5671 (1.7); 8.1932 (1.7); 8.1883 (1.6); 7.8522 (1.3); 7.8484 (2.0); 7.8447 (1.1); 7.7232 (0.9); 7.7182 (0.8); 7.7035 (1.0); 7.6986 (0.9); 7.6071 (1.3); 7.5215 (1.2); 7.4484 (1.3); 7.4288 (1.1); 7.3468 (0.6); 7.3271 (0.6); 7.2608 (15.9); 5.6715 (0.6); 5.6540 (0.7); 5.6352 (0.6); 3.9033 (11.0); 2.7051 (7.7); 1.5575 (16.0); 1.4531 (4.1); 1.4365 (4.1); 1.2649 (0.5); 0.8820 (0.6); -0.0002 (18.0); -0.0084 (1.0) I.2-123: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6323 (2.7); 8.6263 (3.0); 8.5559 (3.0); 8.5498 (2.4); 8.1965 (2.4); 8.1917 (2.2); 7.8075 (2.0); 7.7320 (1.3); 7.7271 (1.2); 7.7124 (1.5); 7.7075 (1.3); 7.6743 (1.3); 7.6694 (1.1); 7.6535 (1.8); 7.6486 (1.6); 7.5603 (2.9); 7.5395 (2.1); 7.4479 (1.8); 7.4283 (1.6); 7.3800 (0.8); 7.3607 (0.8); 7.2619 (9.4); 5.6834 (0.8); 5.6660 (1.1); 5.6475 (0.8); 5.2997 (8.8); 3.9011 (16.0); 2.7034 (11.3); 1.5892 (11.0); 1.4534 (6.0); 1.4367 (6.0); 1.2613 (0.6); 0.8818 (0.7); -0.0002 (10.6); - 0.0081 (0.6) BCS241005-Ausland STR 226 I.2-124: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6239 (2.0); 8.6180 (2.3); 8.5670 (2.3); 8.5611 (1.8); 8.2006 (1.9); 8.1958 (1.8); 7.7493 (1.0); 7.7444 (0.9); 7.7297 (1.1); 7.7248 (1.0); 7.5253 (1.8); 7.4469 (2.2); 7.4263 (1.3); 7.3055 (0.7); 7.2863 (0.8); 7.2607 (16.4); 7.1678 (1.4); 5.6857 (0.7); 5.6683 (0.8); 5.6500 (0.6); 3.8974 (11.8); 2.7028 (8.8); 2.4326 (8.2); 1.5578 (16.0); 1.4560 (4.7); 1.4394 (4.6); -0.0002 (18.5); -0.0082 (1.0) I.2-125: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6381 (1.0); 8.6321 (1.2); 8.5726 (1.2); 8.5665 (1.0); 8.1938 (1.0); 8.1888 (0.9); 7.7229 (0.5); 7.7025 (1.6); 7.6983 (1.2); 7.5646 (0.7); 7.4489 (0.7); 7.4290 (0.6); 7.3716 (0.8); 7.2606 (15.7); 3.9035 (6.3); 2.7054 (4.4); 1.5501 (16.0); 1.4529 (2.4); 1.4363 (2.4); -0.0002 (17.9); -0.0081 (1.0) I.2-126: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6342 (2.6); 8.6283 (3.2); 8.5909 (3.2); 8.5850 (2.4); 8.3137 (2.6); 8.1970 (1.4); 8.1772 (1.5); 8.0071 (3.1); 7.9334 (1.2); 7.9143 (1.5); 7.8427 (1.8); 7.8385 (2.7); 7.8345 (1.7); 7.7492 (2.0); 7.7449 (2.8); 7.6612 (1.3); 7.6423 (2.3); 7.6230 (1.1); 7.2605 (27.0); 7.1397 (0.9); 7.1196 (1.0); 5.5673 (1.0); 5.5499 (1.0); 5.5309 (0.5); 3.9509 (16.0); 1.8570 (0.6); 1.8388 (0.9); 1.8225 (0.8); 1.8044 (0.8); 1.7869 (0.9); 1.7683 (1.1); 1.7501 (0.9); 1.7333 (0.6); 1.5530 (7.0); 0.7830 (3.2); 0.7644 (6.4); 0.7459 (2.9); -0.0002 (33.1); -0.0084 (1.4) I.2-127: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6335 (2.7); 8.6278 (3.3); 8.5907 (3.3); 8.5849 (2.5); 8.3134 (2.9); 8.1966 (1.6); 8.1768 (1.7); 8.0069 (3.3); 7.9330 (1.5); 7.9140 (1.7); 7.8383 (2.9); 7.7445 (3.0); 7.6610 (1.5); 7.6418 (2.6); 7.6223 (1.3); 7.2606 (22.0); 7.1374 (1.1); 7.1166 (1.1); 5.5852 (0.6); 5.5671 (1.1); 5.5498 (1.1); 5.5307 (0.6); 3.9508 (16.0); 1.8563 (0.7); 1.8381 (1.0); 1.8201 (1.0); 1.8037 (0.9); 1.7861 (1.0); 1.7675 (1.2); 1.7494 (1.1); 1.7321 (0.7); 1.5547 (11.7); 0.7823 (3.5); 0.7639 (7.0); 0.7455 (3.2); -0.0002 (27.0); -0.0082 (1.6) I.2-128: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6265 (2.0); 8.6205 (2.4); 8.5728 (2.4); 8.5668 (1.8); 8.3731 (2.0); 8.1868 (1.0); 8.1675 (1.1); 7.9899 (0.9); 7.9705 (1.0); 7.9241 (2.1); 7.9191 (2.1); 7.6672 (1.0); 7.6620 (0.9); 7.6468 (2.2); 7.6414 (1.4); 7.6281 (1.8); 7.6087 (0.9); 7.5383 (2.3); 7.5176 (1.8); 7.2604 (33.0); 7.2325 (1.0); 5.1449 (0.8); 5.1244 (1.5); 5.1038 (0.8); 3.9508 (12.2); 2.0076 (2.8); 1.5478 (16.0); 1.2039 (0.7); 1.1832 (0.6); 0.5080 (0.6); 0.3840 (0.6); 0.3725 (0.7); 0.3610 (0.6); 0.3524 (0.6); 0.3375 (0.7); 0.3256 (0.7); 0.0609 (0.5); 0.0491 (0.6); 0.0372 (0.6); 0.0245 (0.6); -0.0002 (39.9); -0.0083 (2.0) I.2-129: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6272 (2.7); 8.6212 (3.2); 8.5730 (3.1); 8.5670 (2.5); 8.3731 (2.7); 8.1873 (1.4); 8.1674 (1.6); 7.9907 (1.2); 7.9709 (1.5); 7.9244 (2.9); 7.9192 (2.8); 7.6677 (1.3); 7.6622 (1.2); 7.6469 (3.0); 7.6414 (1.8); 7.6279 (2.4); 7.6083 (1.2); 7.5380 (3.0); 7.5173 (2.5); 7.2602 (76.0); 5.1440 (1.1); 5.1237 (2.1); 5.1031 (1.1); 3.9507 (16.0); 2.0078 (2.1); 1.5437 (14.7); 1.2038 (0.9); BCS241005-Ausland STR 227 1.1836 (0.9); 0.5089 (0.8); 0.3938 (0.8); 0.3832 (0.8); 0.3724 (1.0); 0.3519 (0.9); 0.3374 (0.9); 0.3249 (1.0); 0.3123 (0.7); 0.0608 (1.0); 0.0496 (1.0); 0.0352 (1.2); -0.0002 (94.0) I.2-130: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6269 (1.7); 8.6209 (2.0); 8.5885 (2.0); 8.5827 (1.4); 8.3425 (1.7); 8.1947 (0.9); 8.1752 (1.0); 8.0276 (1.9); 7.9763 (0.9); 7.9569 (0.9); 7.8481 (1.7); 7.7623 (1.8); 7.6701 (0.8); 7.6507 (1.5); 7.6312 (0.7); 7.2608 (18.6); 7.0983 (0.6); 7.0764 (0.6); 5.5246 (0.7); 5.5054 (0.9); 5.4829 (0.7); 3.9567 (9.6); 2.0078 (2.0); 1.9963 (0.6); 1.5559 (16.0); 0.8850 (4.0); 0.8681 (3.8); 0.6384 (3.8); 0.6215 (3.7); -0.0002 (18.0); -0.0082 (1.0) I.2-131: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6272 (1.5); 8.6212 (1.9); 8.5886 (1.8); 8.5827 (1.3); 8.3424 (1.5); 8.1946 (0.8); 8.1751 (0.8); 8.0313 (1.1); 8.0276 (1.8); 8.0240 (1.0); 7.9763 (0.7); 7.9569 (0.8); 7.8524 (1.0); 7.8482 (1.6); 7.8442 (0.9); 7.7667 (1.1); 7.7624 (1.6); 7.7583 (0.9); 7.6702 (0.7); 7.6509 (1.3); 7.6314 (0.6); 7.2607 (27.4); 7.0997 (0.5); 7.0765 (0.5); 5.5247 (0.6); 5.5052 (0.7); 5.4830 (0.6); 3.9568 (9.2); 2.0078 (2.0); 1.9966 (0.6); 1.5526 (16.0); 0.8852 (3.5); 0.8683 (3.4); 0.6385 (3.3); 0.6216 (3.2); -0.0002 (26.1); -0.0083 (1.5) I.2-132: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6747 (2.5); 8.6687 (3.1); 8.6320 (3.1); 8.6261 (2.4); 8.3107 (2.5); 8.2032 (1.3); 8.1833 (1.4); 7.9926 (1.8); 7.9891 (3.0); 7.9855 (1.7); 7.8777 (1.2); 7.8587 (1.4); 7.8383 (1.8); 7.8341 (2.7); 7.8301 (1.6); 7.7324 (1.9); 7.7284 (2.7); 7.7243 (1.5); 7.6488 (1.3); 7.6295 (2.2); 7.6102 (1.1); 7.4047 (0.9); 7.3848 (0.9); 7.2603 (35.2); 6.0538 (0.6); 6.0363 (1.3); 6.0177 (1.0); 5.9901 (0.8); 5.9650 (0.8); 5.9485 (1.2); 5.9321 (0.6); 5.9226 (0.8); 5.9068 (0.6); 5.2762 (1.8); 5.2509 (1.7); 5.0961 (1.7); 5.0537 (1.6); 3.9474 (16.0); 1.5462 (15.6); -0.0002 (43.0); -0.0082 (2.6) I.2-133: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6747 (1.0); 8.6687 (1.2); 8.6322 (1.1); 8.6261 (0.9); 8.3105 (0.9); 8.1836 (0.5); 7.9927 (0.7); 7.9892 (1.1); 7.9855 (0.6); 7.8386 (0.6); 7.8346 (1.0); 7.8304 (0.6); 7.7325 (0.7); 7.7284 (1.0); 7.7243 (0.6); 7.6296 (0.8); 7.2601 (31.1); 5.2765 (0.6); 5.2510 (0.6); 5.0961 (0.6); 5.0534 (0.5); 3.9474 (6.0); 1.5403 (16.0); -0.0002 (38.4); -0.0083 (2.1) I.2-134: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6354 (1.6); 8.6296 (1.9); 8.5841 (1.8); 8.5782 (1.5); 8.3727 (1.6); 8.1911 (0.8); 8.1715 (0.9); 7.9787 (0.8); 7.9594 (0.9); 7.7249 (1.7); 7.6509 (0.8); 7.6314 (1.4); 7.6121 (0.7); 7.5835 (1.2); 7.3784 (1.2); 7.2607 (16.0); 5.1385 (0.6); 5.1179 (1.2); 5.0973 (0.6); 3.9531 (9.2); 1.5574 (16.0); 1.2119 (0.5); 1.1914 (0.5); 0.3802 (0.5); 0.3429 (0.5); 0.3306 (0.6); 0.0474 (0.5); 0.0351 (0.6); -0.0002 (15.0); -0.0083 (0.9) I.2-135: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6353 (1.0); 8.6294 (1.2); 8.5840 (1.2); 8.5782 (1.0); 8.3725 (1.1); 8.1905 (0.6); 8.1714 (0.7); 7.9778 (0.6); 7.9591 (0.6); 7.7246 (1.2); 7.6504 (0.6); 7.6312 (1.0); BCS241005-Ausland STR 228 7.6120 (0.5); 7.5841 (0.9); 7.3785 (0.9); 7.2606 (15.6); 5.1174 (0.9); 3.9531 (6.3); 1.5518 (16.0); 0.0456 (0.5); 0.0350 (0.6); 0.0225 (0.6); -0.0002 (15.0) I.2-136: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6306 (2.0); 8.6248 (2.4); 8.5791 (2.4); 8.5732 (1.9); 8.3173 (2.1); 8.1955 (1.1); 8.1759 (1.2); 7.9420 (1.0); 7.9181 (2.8); 7.9131 (2.2); 7.6616 (2.0); 7.6568 (1.0); 7.6417 (3.0); 7.6358 (1.4); 7.6230 (1.0); 7.5374 (2.4); 7.5166 (1.7); 7.2604 (26.5); 7.1889 (0.8); 7.1682 (0.8); 5.5883 (0.8); 5.5714 (0.8); 3.9492 (12.4); 1.8404 (0.7); 1.8236 (0.6); 1.8063 (0.5); 1.7811 (0.6); 1.7627 (0.9); 1.7447 (0.7); 1.7282 (0.5); 1.5496 (16.0); 0.7828 (2.5); 0.7644 (5.1); 0.7459 (2.4); -0.0002 (32.3); -0.0080 (2.0) I.2-137: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6307 (2.3); 8.6248 (2.8); 8.5791 (2.7); 8.5732 (2.2); 8.3174 (2.3); 8.1958 (1.2); 8.1759 (1.3); 7.9421 (1.1); 7.9184 (3.1); 7.9131 (2.6); 7.6618 (2.2); 7.6567 (1.2); 7.6418 (3.2); 7.6358 (1.6); 7.6232 (1.0); 7.5374 (2.7); 7.5168 (2.0); 7.2605 (29.6); 7.1901 (0.8); 7.1695 (0.8); 5.5886 (0.8); 5.5714 (0.8); 3.9492 (14.2); 1.8405 (0.8); 1.8224 (0.7); 1.8064 (0.6); 1.7816 (0.6); 1.7631 (1.0); 1.7451 (0.8); 1.7281 (0.6); 1.5503 (16.0); 0.7830 (2.7); 0.7645 (5.7); 0.7459 (2.6); -0.0002 (36.2); -0.0084 (2.1) I.2-138: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6720 (1.6); 8.6660 (1.9); 8.6205 (1.9); 8.6147 (1.5); 8.3142 (1.6); 8.2014 (0.8); 8.1817 (1.0); 7.9000 (1.7); 7.8947 (1.6); 7.8827 (0.9); 7.8632 (1.0); 7.6469 (1.5); 7.6415 (0.8); 7.6269 (1.9); 7.6202 (1.2); 7.6094 (0.7); 7.5284 (1.8); 7.5077 (1.4); 7.4563 (0.6); 7.4368 (0.6); 7.2600 (40.2); 6.0538 (0.9); 6.0355 (0.6); 5.9923 (0.5); 5.9670 (0.5); 5.9501 (0.7); 5.2703 (1.1); 5.2444 (1.0); 5.0931 (1.1); 5.0500 (1.0); 3.9457 (9.6); 2.1717 (0.9); 1.5401 (16.0); -0.0002 (51.0) I.2-139: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6723 (2.5); 8.6663 (3.0); 8.6206 (2.9); 8.6145 (2.3); 8.3143 (2.4); 8.3104 (1.4); 8.2014 (1.3); 8.1817 (1.4); 7.9000 (2.7); 7.8950 (2.6); 7.8832 (1.2); 7.8638 (1.4); 7.6470 (2.2); 7.6414 (1.3); 7.6276 (2.8); 7.6207 (1.8); 7.6091 (1.1); 7.5284 (2.9); 7.5076 (2.1); 7.4579 (0.8); 7.4385 (0.8); 7.2603 (34.1); 6.0711 (0.6); 6.0549 (1.1); 6.0354 (0.9); 5.9922 (0.7); 5.9669 (0.8); 5.9504 (1.1); 5.9338 (0.6); 5.9245 (0.8); 5.9085 (0.6); 5.2701 (1.7); 5.2448 (1.6); 5.0928 (1.6); 5.0503 (1.5); 3.9457 (16.0); 2.0074 (1.0); 1.5463 (10.8); -0.0002 (42.6); -0.0084 (2.4) I.2-140: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6753 (2.5); 8.6695 (3.0); 8.6320 (3.0); 8.6260 (2.4); 8.3108 (2.7); 8.2031 (1.5); 8.1840 (1.6); 7.8768 (1.5); 7.8536 (6.5); 7.8499 (6.2); 7.7970 (2.7); 7.6489 (1.4); 7.6296 (2.4); 7.6106 (1.1); 7.4183 (1.0); 7.3995 (1.1); 7.2601 (27.5); 6.0547 (0.7); 6.0370 (1.4); 6.0183 (1.1); 5.9890 (0.7); 5.9640 (0.8); 5.9476 (1.2); 5.9310 (0.6); 5.9213 (0.8); 5.9057 (0.6); 5.2757 (2.0); 5.2509 (1.8); 5.0966 (1.9); 5.0539 (1.7); 3.9475 (14.8); 1.5469 (16.0); -0.0002 (34.1) BCS241005-Ausland STR 229 I.2-141: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6758 (2.5); 8.6698 (3.1); 8.6321 (3.0); 8.6261 (2.3); 8.3110 (2.4); 8.2034 (1.3); 8.1837 (1.4); 7.8772 (1.2); 7.8540 (6.5); 7.8497 (6.3); 7.8007 (2.0); 7.7965 (2.8); 7.7923 (1.4); 7.6491 (1.3); 7.6297 (2.2); 7.6104 (1.1); 7.4228 (0.8); 7.4028 (0.9); 7.2606 (20.6); 6.0543 (0.6); 6.0377 (1.2); 6.0187 (0.9); 5.9895 (0.8); 5.9645 (0.8); 5.9477 (1.2); 5.9314 (0.6); 5.9220 (0.8); 5.9060 (0.6); 5.2763 (1.8); 5.2511 (1.6); 5.0971 (1.7); 5.0545 (1.6); 3.9476 (16.0); 1.5536 (4.7); -0.0002 (25.2); -0.0083 (1.4) I.2-142: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6321 (0.7); 8.6261 (0.9); 8.5881 (0.9); 8.5823 (0.7); 8.3460 (0.7); 7.8760 (0.8); 7.6543 (0.7); 7.6423 (0.6); 7.5381 (0.5); 7.2605 (16.7); 3.9572 (4.4); 1.5485 (16.0); 0.8852 (1.7); 0.8683 (1.7); 0.6488 (1.6); 0.6319 (1.6); -0.0002 (16.1); -0.0084 (0.9) I.2-143: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6321 (2.2); 8.6262 (2.6); 8.5882 (2.6); 8.5823 (2.0); 8.3466 (2.2); 8.1981 (1.2); 8.1784 (1.3); 7.9767 (1.0); 7.9572 (1.2); 7.8764 (2.5); 7.6740 (1.1); 7.6546 (2.1); 7.6428 (1.8); 7.5383 (1.6); 7.2610 (17.1); 7.1561 (0.8); 7.1335 (0.8); 5.5483 (0.8); 5.5293 (1.1); 5.5070 (0.9); 3.9573 (12.9); 2.0175 (0.8); 2.0075 (1.2); 2.0004 (0.8); 1.9831 (0.5); 1.5630 (16.0); 0.8855 (5.2); 0.8687 (5.0); 0.6489 (4.9); 0.6320 (4.8); -0.0002 (16.3); -0.0083 (1.0) I.2-144: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6857 (2.4); 8.6798 (2.8); 8.6357 (2.9); 8.6298 (2.3); 8.3156 (2.6); 8.2069 (1.4); 8.1873 (1.5); 7.8816 (1.2); 7.8621 (1.6); 7.8524 (2.0); 7.8488 (3.0); 7.6537 (1.3); 7.6343 (2.3); 7.6141 (1.9); 7.6074 (2.2); 7.5243 (2.0); 7.4996 (1.0); 7.4802 (1.0); 7.2628 (9.6); 6.0655 (0.7); 6.0486 (1.3); 6.0297 (1.0); 5.9950 (0.8); 5.9700 (0.8); 5.9532 (1.2); 5.9367 (0.6); 5.9275 (0.8); 5.9114 (0.6); 5.3017 (3.4); 5.2861 (1.9); 5.2609 (1.8); 5.1030 (1.8); 5.0607 (1.6); 3.9490 (16.0); 1.5931 (0.7); -0.0002 (10.8); -0.0083 (0.6) I.2-145: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6843 (1.5); 8.6784 (1.7); 8.6363 (1.9); 8.6307 (1.5); 8.3148 (2.0); 8.2071 (1.1); 8.1874 (1.2); 7.8796 (0.9); 7.8604 (1.2); 7.8502 (1.6); 7.8466 (2.4); 7.8428 (1.4); 7.6538 (1.0); 7.6344 (1.8); 7.6147 (1.1); 7.6055 (1.6); 7.5252 (1.5); 7.4811 (0.7); 7.4618 (0.8); 7.2619 (25.0); 6.0475 (1.0); 6.0286 (0.7); 5.9928 (0.6); 5.9678 (0.6); 5.9509 (0.9); 5.9344 (0.5); 5.9251 (0.6); 5.3021 (3.8); 5.2855 (1.4); 5.2602 (1.3); 5.1026 (1.3); 5.0598 (1.2); 3.9492 (13.0); 1.5614 (16.0); -0.0002 (28.1); -0.0084 (1.4) I.2-146: 1H-NMR(300.1 MHz, d6-DMSO): δ= 8.9065 (2.2); 8.8839 (2.5); 8.7724 (8.5); 8.7642 (10.4); 8.7093 (7.0); 8.7017 (6.1); 8.2112 (0.4); 7.9852 (7.0); 7.9644 (4.6); 7.9352 (4.4); 7.9228 (5.6); 7.7578 (3.4); 7.7299 (2.8); 7.6970 (2.2); 7.6715 (9.8); 7.6608 (5.8); 7.6326 (1.4); 5.1651 (0.4); 5.0985 (0.5); 5.0777 (1.4); 5.0548 (2.0); 5.0324 (1.3); 3.8443 (2.6); 3.7212 (16.0); 3.3250 (2.2); 2.5104 (17.0); 2.5047 (21.1); 2.4989 (15.0); 2.0774 (1.6); 1.4809 (15.0); 1.4582 (14.6); -0.0002 (8.4) BCS241005-Ausland STR 230 I.2-147: 1H-NMR(300.1 MHz, d6-DMSO): δ= 13.1992 (2.3); 8.9446 (2.3); 8.9222 (2.5); 8.7555 (6.7); 8.7481 (7.3); 8.6987 (10.4); 8.6906 (8.0); 8.0631 (4.0); 7.9822 (5.5); 7.9757 (6.6); 7.9622 (9.2); 7.9556 (9.0); 7.7388 (3.0); 7.7102 (3.2); 7.6745 (13.8); 7.6460 (1.6); 7.6191 (0.9); 5.1632 (0.5); 5.0343 (1.4); 5.0126 (1.9); 4.9909 (1.3); 3.3203 (4.0); 2.5080 (36.6); 2.5027 (44.2); 2.0754 (4.5); 1.4639 (16.0); 1.4411 (15.8); -0.0002 (56.5) I.2-148: 1H-NMR(300.0 MHz, d6-DMSO): δ= 12.6945 (2.0); 8.8287 (9.2); 8.8051 (8.8); 8.6495 (10.8); 8.6278 (16.0); 8.6203 (10.7); 8.0647 (0.4); 7.9841 (4.9); 7.9566 (4.6); 7.8913 (10.6); 7.7809 (1.3); 7.6368 (11.8); 7.2156 (6.8); 7.1872 (6.5); 5.2303 (0.5); 5.1824 (0.7); 5.0159 (2.6); 4.9564 (0.4); 3.8244 (15.8); 3.6702 (2.4); 3.5089 (0.4); 3.3227 (33.2); 2.7286 (0.7); 2.7228 (0.5); 2.5139 (42.3); 2.5082 (81.8); 2.5023 (111.4); 2.4966 (75.6); 2.4908 (36.0); 2.4331 (0.4); 2.2713 (0.6); 1.7545 (0.5); 1.4909 (9.0); 1.4712 (9.5); 1.3817 (1.2); 1.3298 (2.0); 1.3138 (2.1); 1.2368 (0.6); 0.0108 (2.0); -0.0002 (61.8); -0.0112 (2.0) I.2-149: 1H-NMR(300.0 MHz, d6-DMSO): δ= 8.7916 (4.9); 8.7678 (4.9); 8.6694 (6.6); 8.6622 (8.4); 8.6356 (14.2); 8.6274 (9.5); 7.9601 (2.7); 7.9319 (2.5); 7.8460 (7.4); 7.7727 (0.9); 7.7382 (0.7); 7.7176 (1.0); 7.7103 (1.1); 7.6271 (7.0); 7.2291 (5.4); 7.2000 (5.0); 5.1666 (0.4); 5.1428 (0.4); 5.0747 (1.4); 5.0541 (1.8); 5.0333 (1.3); 3.8353 (11.9); 3.8171 (5.2); 3.8058 (3.8); 3.7948 (4.2); 3.7495 (16.0); 3.6864 (1.5); 3.3231 (14.0); 2.5083 (37.9); 2.5028 (49.5); 2.4974 (35.7); 2.0758 (0.8); 1.4985 (6.4); 1.4785 (6.6); 1.3467 (1.2); 1.2334 (0.6); 0.0106 (0.8); -0.0002 (19.8); -0.0111 (0.8) I.2-150: 1H-NMR(300.0 MHz, d6-DMSO): δ= 12.6812 (7.1); 9.3083 (0.5); 9.2863 (0.4); 8.9462 (6.3); 8.9229 (7.0); 8.6615 (10.8); 8.6398 (16.0); 8.6318 (10.5); 8.4243 (1.3); 8.4162 (1.2); 8.1404 (0.4); 8.1361 (0.3); 8.0698 (0.9); 8.0647 (1.4); 8.0590 (1.0); 7.9816 (3.8); 7.9526 (3.7); 7.8822 (5.2); 7.8254 (2.2); 7.7919 (5.9); 7.6918 (5.9); 7.5930 (4.4); 7.5298 (0.5); 7.5090 (0.4); 7.2200 (4.1); 7.1910 (4.3); 5.4757 (0.3); 5.4532 (0.5); 5.4313 (0.4); 5.2000 (0.5); 5.1652 (0.4); 5.0531 (2.2); 3.9633 (0.9); 3.8961 (0.3); 3.8296 (13.3); 3.6664 (1.9); 3.3316 (59.0); 2.7319 (0.4); 2.5110 (37.0); 2.5052 (49.5); 2.4996 (34.7); 1.5357 (3.4); 1.5118 (8.6); 1.4864 (8.2); 1.3495 (1.7); 1.2670 (0.4); 1.2329 (1.2); 0.8531 (0.4); 0.0107 (0.7); -0.0002 (21.7); -0.0112 (0.7) I.2-151: 1H-NMR(300.1 MHz, d6-DMSO): δ= 8.9424 (0.3); 8.8978 (4.5); 8.8748 (4.8); 8.7809 (0.4); 8.6721 (9.2); 8.6463 (12.6); 8.6382 (9.1); 8.5027 (0.4); 7.9514 (2.9); 7.9231 (3.0); 7.8442 (4.8); 7.7363 (5.0); 7.6986 (6.3); 7.6252 (0.9); 7.6094 (0.8); 7.5896 (0.8); 7.5417 (3.6); 7.2285 (3.8); 7.1994 (4.0); 5.1637 (0.7); 5.1218 (2.0); 5.1001 (2.3); 3.9977 (0.4); 3.8389 (11.9); 3.7461 (16.0); 3.6024 (0.7); 3.5821 (0.6); 3.5129 (0.8); 3.4796 (0.4); 3.4268 (0.3); 3.3997 (0.4); 3.3200 (18.0); 3.1801 (0.3); 2.7295 (0.5); 2.7255 (0.4); 2.5029 (41.9); 2.2720 (0.4); 1.5095 (7.0); 1.4892 (7.6); 1.3806 (1.6); 1.3558 (1.7); 1.2344 (0.8); 1.2191 (0.6); -0.0002 (10.2); -0.0621 (0.3) BCS241005-Ausland STR 231 I.2-152: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6463 (2.4); 8.6402 (3.1); 8.5986 (2.6); 8.5926 (2.1); 8.3669 (1.1); 8.3628 (1.9); 8.3591 (1.1); 8.2773 (3.2); 8.2121 (0.7); 8.2090 (1.0); 8.2051 (0.8); 8.1926 (0.8); 8.1888 (1.1); 8.1856 (0.8); 8.0312 (1.4); 7.9877 (0.7); 7.9847 (0.8); 7.9803 (0.7); 7.9685 (0.8); 7.9642 (1.0); 7.9611 (0.7); 7.6853 (1.0); 7.6661 (1.8); 7.6465 (0.9); 7.2845 (0.6); 7.2613 (18.8); 5.5942 (0.8); 5.5752 (0.9); 5.5717 (0.9); 5.5526 (0.8); 3.9622 (16.0); 2.0553 (0.6); 2.0373 (0.6); 1.5762 (2.5); 0.9110 (5.0); 0.8942 (4.9); 0.6640 (4.7); 0.6472 (4.6); 0.0080 (0.6); -0.0002 (22.1); -0.0085 (0.7) I.2-153: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6455 (2.2); 8.6395 (2.8); 8.5984 (2.3); 8.5924 (1.8); 8.3664 (1.0); 8.3623 (1.7); 8.3585 (1.0); 8.2766 (2.8); 8.2119 (0.6); 8.2087 (0.9); 8.2049 (0.6); 8.1924 (0.7); 8.1886 (0.9); 8.1854 (0.6); 8.0316 (1.2); 7.9864 (0.6); 7.9833 (0.7); 7.9790 (0.6); 7.9673 (0.7); 7.9630 (0.8); 7.9598 (0.6); 7.6853 (0.9); 7.6660 (1.6); 7.6465 (0.7); 7.2778 (0.5); 7.2610 (22.0); 5.5946 (0.7); 5.5756 (0.8); 5.5720 (0.8); 5.5530 (0.7); 3.9622 (13.4); 2.0543 (0.6); 2.0363 (0.6); 1.5640 (16.0); 0.9103 (4.3); 0.8934 (4.2); 0.6641 (4.0); 0.6472 (3.9); 0.0079 (0.9); -0.0002 (25.9); -0.0085 (0.7) I.2-154: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6481 (1.5); 8.6421 (1.8); 8.5937 (1.6); 8.5877 (1.3); 8.3920 (0.6); 8.3878 (1.1); 8.3839 (0.6); 8.2691 (1.9); 8.2005 (0.6); 8.1810 (0.6); 8.0235 (0.8); 7.9887 (0.5); 7.9686 (0.6); 7.6621 (0.6); 7.6426 (1.1); 7.6234 (0.5); 7.2607 (26.6); 5.1400 (0.8); 3.9580 (9.3); 1.5534 (16.0); 0.0079 (1.0); -0.0002 (31.3); -0.0085 (0.8) I.2-155: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6479 (1.4); 8.6418 (1.8); 8.5936 (1.6); 8.5876 (1.3); 8.3919 (0.7); 8.3879 (1.2); 8.3837 (0.7); 8.2686 (2.0); 8.2005 (0.6); 8.1808 (0.7); 8.0237 (0.9); 7.9884 (0.6); 7.9691 (0.6); 7.6619 (0.6); 7.6426 (1.2); 7.6233 (0.6); 7.2608 (21.2); 5.1402 (0.9); 5.1195 (0.5); 3.9580 (9.2); 1.5553 (16.0); 0.0079 (0.9); -0.0002 (25.5); -0.0085 (0.8) I.2-158: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6275 (1.2); 8.6217 (1.5); 8.5883 (1.4); 8.5825 (1.1); 8.3428 (1.2); 8.1949 (0.6); 8.1755 (0.7); 7.9739 (0.6); 7.9545 (0.7); 7.8894 (2.7); 7.8853 (2.8); 7.8105 (1.3); 7.6703 (0.6); 7.6509 (1.1); 7.6316 (0.5); 7.2605 (18.2); 5.5285 (0.5); 5.5090 (0.6); 5.4869 (0.5); 3.9569 (7.0); 2.0077 (0.8); 1.5495 (16.0); 0.8848 (2.9); 0.8680 (2.8); 0.6405 (2.8); 0.6237 (2.7); -0.0002 (20.5); - 0.0082 (1.2) I.2-159: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6271 (0.6); 8.6215 (0.7); 8.5880 (0.7); 8.3421 (0.6); 7.8857 (1.4); 7.8109 (0.6); 7.6504 (0.5); 7.2603 (18.5); 3.9569 (3.2); 1.5432 (16.0); 0.8845 (1.4); 0.8678 (1.4); 0.6403 (1.4); 0.6237 (1.3); -0.0002 (21.4) I.2-161: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6319 (1.2); 8.6260 (1.4); 8.5867 (1.4); 8.5809 (1.1); 8.3466 (1.2); 8.1984 (0.6); 8.1787 (0.7); 7.9771 (0.6); 7.9574 (0.6); 7.7306 (1.3); 7.6741 (0.6); 7.6549 (1.0); BCS241005-Ausland STR 232 7.6354 (0.5); 7.6009 (1.0); 7.3860 (0.9); 7.2608 (13.9); 5.5332 (0.6); 3.9574 (7.0); 1.5579 (16.0); 0.8844 (2.8); 0.8676 (2.7); 0.6505 (2.7); 0.6337 (2.6); -0.0002 (15.0); -0.0083 (0.7) I.2-162: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6492 (1.9); 8.6432 (2.8); 8.6213 (2.6); 8.6152 (1.7); 8.1106 (1.3); 8.1070 (2.3); 8.1034 (1.3); 7.8914 (0.6); 7.8880 (0.7); 7.8852 (0.7); 7.8818 (0.6); 7.8695 (0.6); 7.8660 (0.7); 7.8634 (0.7); 7.8599 (0.6); 7.7020 (1.2); 7.6981 (2.1); 7.6940 (1.3); 7.6475 (0.6); 7.6435 (0.7); 7.6375 (0.6); 7.6260 (0.6); 7.6220 (0.7); 7.6159 (0.6); 7.5555 (1.3); 7.3741 (1.2); 7.2608 (21.7); 5.6079 (0.6); 5.5904 (0.8); 5.5718 (0.6); 3.9569 (13.8); 1.5556 (16.0); 1.4897 (4.8); 1.4730 (4.8); 0.0079 (1.0); -0.0002 (26.4); -0.0084 (0.9) I.2-164: 1H-NMR(400.1 MHz, d6-DMSO): δ= 12.9399 (1.8); 9.0780 (2.1); 9.0616 (2.2); 8.6488 (3.0); 8.6428 (6.5); 8.6351 (6.6); 8.6291 (3.0); 8.0954 (4.0); 8.0911 (3.8); 8.0624 (4.5); 8.0577 (4.3); 7.7824 (3.1); 7.7656 (4.9); 7.7609 (4.8); 7.7120 (5.3); 7.6910 (3.1); 7.4535 (3.0); 7.4336 (2.7); 5.3286 (1.3); 5.3117 (2.0); 5.2948 (1.3); 3.7901 (0.4); 3.3319 (15.8); 2.5930 (16.0); 2.5084 (19.7); 2.5041 (25.3); 2.4999 (18.2); 1.4667 (7.5); 1.4495 (7.4); -0.0002 (13.4); -0.0082 (0.6) I.2-165: 1H-NMR(400.1 MHz, d6-DMSO): δ= 9.0582 (1.6); 9.0418 (1.7); 8.6617 (2.5); 8.6556 (4.3); 8.6417 (4.4); 8.6358 (3.0); 8.0649 (3.0); 8.0604 (3.3); 8.0465 (3.5); 8.0417 (3.7); 7.8182 (1.5); 7.8135 (1.6); 7.7986 (1.8); 7.7939 (1.9); 7.7776 (1.4); 7.7727 (1.4); 7.7566 (2.4); 7.7517 (2.5); 7.7157 (3.9); 7.6947 (2.1); 7.4759 (2.2); 7.4562 (2.1); 5.3154 (1.0); 5.2983 (1.6); 5.2814 (1.1); 5.2643 (0.4); 3.7886 (16.0); 3.3240 (26.0); 2.6712 (0.5); 2.6667 (0.5); 2.5772 (12.7); 2.5067 (37.5); 2.5024 (48.6); 2.4981 (37.3); 2.0757 (0.4); 1.4691 (5.9); 1.4519 (6.0); -0.0002 (15.4) I.2-166: 1H-NMR(400.1 MHz, d6-DMSO): δ= 12.9448 (2.5); 9.1858 (2.0); 9.1694 (2.1); 8.6573 (2.9); 8.6513 (7.1); 8.6448 (7.3); 8.6387 (3.0); 8.0921 (3.7); 8.0880 (3.6); 7.9585 (2.9); 7.9547 (4.3); 7.9510 (2.8); 7.7796 (2.0); 7.7748 (1.9); 7.7600 (2.4); 7.7549 (3.0); 7.7471 (3.2); 7.7279 (3.2); 7.7259 (3.2); 7.4498 (3.0); 7.4299 (2.7); 5.3495 (1.2); 5.3326 (1.9); 5.3157 (1.2); 3.3326 (11.2); 2.5902 (16.0); 2.5145 (9.6); 2.5105 (17.8); 2.5061 (22.9); 2.5016 (16.2); 2.4975 (7.6); 1.4836 (7.4); 1.4665 (7.3); 0.0078 (0.6); 0.0012 (7.9); -0.0002 (8.6) I.2-167: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6318 (2.1); 8.6258 (3.6); 8.6107 (3.0); 8.6046 (1.7); 8.0352 (0.6); 8.0300 (0.8); 8.0251 (0.6); 8.0211 (0.6); 8.0163 (0.8); 8.0112 (0.6); 7.8311 (0.5); 7.8254 (0.5); 7.8142 (0.6); 7.8062 (0.6); 7.8003 (0.5); 7.7891 (0.5); 7.6993 (1.4); 7.6952 (2.3); 7.6912 (1.4); 7.5518 (1.4); 7.5497 (1.2); 7.3759 (1.2); 7.3739 (1.2); 7.2616 (14.6); 7.2059 (0.5); 7.1866 (0.6); 5.6037 (0.7); 5.5865 (0.8); 5.5846 (0.8); 5.5674 (0.7); 3.9802 (16.0); 1.5756 (15.5); 1.5008 (5.2); 1.4840 (5.2); 0.8819 (0.7); 0.0080 (0.5); -0.0002 (17.4) BCS241005-Ausland STR 233 I.2-168: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6262 (2.3); 8.6202 (3.4); 8.5960 (2.7); 8.5900 (1.9); 8.0363 (0.5); 8.0312 (0.8); 8.0263 (0.6); 8.0223 (0.6); 8.0173 (0.8); 8.0124 (0.5); 7.8395 (0.5); 7.8225 (0.5); 7.8164 (0.7); 7.8145 (0.7); 7.8085 (0.6); 7.7972 (0.6); 7.7916 (1.4); 7.7878 (1.4); 7.7839 (1.1); 7.6663 (1.1); 7.6613 (1.0); 7.6455 (1.6); 7.6405 (1.5); 7.5619 (3.0); 7.5412 (1.9); 7.2617 (13.5); 7.2110 (0.5); 7.1915 (0.5); 5.6114 (0.6); 5.5943 (0.8); 5.5923 (0.8); 5.5752 (0.6); 3.9777 (16.0); 1.5816 (12.5); 1.5010 (5.2); 1.4842 (5.2); 1.2643 (0.6); 1.2599 (0.6); 0.8819 (1.1); -0.0002 (15.8) I.2-169: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7110 (0.6); 8.7049 (0.8); 8.6657 (0.9); 8.6596 (0.7); 7.9187 (0.6); 3.3216 (16.0); 2.5242 (0.9); 2.5195 (1.2); 2.5107 (14.9); 2.5062 (32.0); 2.5016 (44.1); 2.4970 (30.6); 2.4925 (13.6); 1.4893 (1.0); 1.4722 (1.0); 0.0080 (1.1); -0.0002 (37.9); -0.0085 (1.1) I.2-170: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1596 (0.7); 9.1427 (0.7); 8.7063 (1.6); 8.7002 (2.1); 8.6618 (2.3); 8.6557 (1.8); 7.9049 (1.1); 7.9013 (1.0); 7.8921 (1.5); 7.8873 (1.1); 7.8819 (0.6); 7.8711 (1.2); 7.8661 (1.0); 7.7885 (1.9); 7.7677 (1.3); 5.3302 (0.7); 4.0558 (0.7); 4.0380 (2.1); 4.0203 (2.2); 4.0025 (0.7); 3.3190 (16.0); 2.6704 (0.6); 2.5241 (1.7); 2.5194 (2.5); 2.5106 (34.3); 2.5061 (73.1); 2.5015 (100.4); 2.4970 (68.8); 2.4924 (30.1); 2.3286 (0.6); 1.9888 (9.9); 1.9087 (1.4); 1.4872 (2.5); 1.4701 (2.5); 1.3553 (1.0); 1.1925 (2.7); 1.1747 (5.6); 1.1569 (2.7); 0.0079 (2.5); -0.0002 (83.3); -0.0085 (2.3) I.2-171: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.2002 (1.7); 9.1786 (1.8); 8.6149 (14.7); 7.9657 (3.0); 7.9505 (4.5); 7.9425 (4.4); 7.9259 (2.7); 7.9195 (2.2); 7.8882 (1.8); 7.8802 (1.5); 7.8595 (2.0); 7.8517 (1.8); 7.8082 (3.9); 7.7805 (2.8); 7.2881 (2.8); 7.2591 (2.6); 5.3847 (1.0); 5.3626 (1.6); 5.3401 (1.1); 3.8907 (16.0); 3.3297 (5.0); 2.5102 (7.8); 2.5044 (10.4); 2.4987 (7.7); 1.4754 (5.9); 1.4526 (5.9); -0.0002 (5.6) I.2-172: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.1887 (1.4); 9.1668 (1.4); 8.6344 (1.3); 8.6254 (9.3); 8.6165 (1.2); 7.9564 (2.6); 7.9525 (2.6); 7.9455 (4.4); 7.9375 (4.4); 7.9286 (2.4); 7.9185 (2.7); 7.9117 (1.9); 7.9002 (1.8); 7.8923 (1.3); 7.8104 (3.3); 7.7827 (2.2); 7.3140 (2.3); 7.2855 (2.1); 5.3731 (0.9); 5.3503 (1.4); 5.3281 (0.9); 3.8932 (14.4); 3.7640 (16.0); 3.3346 (10.6); 2.5098 (7.2); 2.5040 (9.2); 2.4983 (6.4); 1.4808 (5.2); 1.4579 (5.0); -0.0002 (4.0) I.2-173: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.1321 (1.6); 9.1101 (1.6); 8.6270 (9.6); 8.1369 (3.1); 8.1302 (3.4); 7.9515 (2.6); 7.9440 (3.8); 7.9238 (1.9); 7.9139 (2.2); 7.9062 (1.6); 7.8953 (1.9); 7.8853 (2.6); 7.8775 (1.9); 7.6561 (1.6); 7.6315 (1.3); 7.6276 (1.3); 7.3175 (2.6); 7.2886 (2.4); 5.3609 (1.0); 5.3383 (1.5); 5.3156 (1.0); 3.8975 (15.0); 3.7667 (16.0); 3.3322 (16.4); 2.5121 (4.0); 2.5066 (5.1); 1.4786 (5.6); 1.4559 (5.4); -0.0002 (2.4) BCS241005-Ausland STR 234 I.2-174: 1H-NMR(400.1 MHz, d6-DMSO): δ= 9.0133 (3.7); 8.9356 (0.3); 8.7100 (13.7); 8.7046 (16.0); 8.6682 (11.1); 8.1252 (0.7); 8.0754 (8.6); 8.0091 (0.5); 7.9177 (5.2); 7.8578 (8.5); 7.8537 (8.2); 7.8364 (9.9); 7.8321 (9.5); 7.6467 (10.6); 7.6255 (8.6); 7.4995 (15.3); 7.4793 (13.9); 4.9534 (2.8); 3.9643 (0.8); 3.9343 (0.4); 3.8525 (3.0); 3.8214 (3.6); 3.7609 (3.0); 3.7219 (3.1); 3.3361 (161.0); 3.3125 (2.3); 2.5417 (0.5); 2.5100 (35.8); 2.5057 (46.6); 2.5015 (33.5); 2.3325 (0.5); 2.1570 (6.4); 2.0114 (0.4); 1.4133 (11.7); 1.2994 (0.4); 1.2322 (2.1); 0.8515 (0.4); -0.0002 (16.1) I.2-175: 1H-NMR(300.0 MHz, d6-DMSO): δ= 8.8849 (6.4); 8.8609 (6.2); 8.6674 (10.2); 8.6410 (15.0); 8.6329 (10.2); 7.9811 (1.1); 7.9458 (3.1); 7.9166 (3.2); 7.8342 (6.2); 7.7311 (9.0); 7.2282 (4.0); 7.1980 (4.1); 5.2079 (0.5); 5.1827 (0.6); 5.0780 (2.1); 3.9823 (0.4); 3.9676 (0.5); 3.8373 (13.6); 3.7365 (16.0); 3.6549 (1.7); 3.6144 (0.7); 3.5508 (0.4); 3.5046 (0.3); 3.3243 (106.6); 3.3007 (3.2); 2.7335 (0.4); 2.5083 (39.0); 2.5030 (50.8); 2.2735 (0.4); 1.6144 (0.4); 1.5833 (0.4); 1.5088 (7.6); 1.4891 (7.8); 1.3495 (1.6); 1.2341 (2.4); 1.0589 (0.3); 0.8523 (0.6); 0.8238 (0.4); 0.8057 (0.4); -0.0001 (20.1) I.2-176: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.1342 (1.5); 9.1123 (1.6); 8.7130 (0.4); 8.7039 (3.1); 8.6955 (4.4); 8.6863 (0.5); 8.6689 (4.1); 8.6608 (2.8); 8.0941 (3.2); 8.0873 (3.6); 8.0579 (2.9); 8.0507 (3.2); 7.9238 (1.4); 7.9163 (1.3); 7.8961 (1.9); 7.8887 (1.8); 7.8787 (1.6); 7.8717 (1.4); 7.8500 (1.9); 7.8430 (1.7); 7.7347 (3.3); 7.7260 (0.6); 7.7182 (0.6); 7.7070 (2.5); 7.6529 (1.4); 7.6482 (1.6); 7.6342 (0.7); 7.6241 (1.2); 7.6197 (1.2); 7.5968 (0.4); 5.3023 (0.8); 5.2800 (1.3); 5.2574 (0.8); 3.8871 (2.2); 3.8290 (16.0); 3.6192 (1.9); 3.3381 (21.4); 3.3140 (0.5); 2.5113 (6.3); 2.5055 (8.4); 2.4998 (5.9); 1.5236 (0.7); 1.4927 (5.0); 1.4698 (4.9); -0.0002 (4.2) I.2-177: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.1944 (1.3); 9.1723 (1.3); 8.7043 (2.8); 8.6960 (4.0); 8.6696 (4.1); 8.6615 (2.7); 8.0543 (2.8); 8.0471 (3.0); 7.9288 (2.4); 7.9217 (3.5); 7.9126 (2.5); 7.9016 (2.0); 7.8940 (1.8); 7.8848 (2.2); 7.8782 (1.6); 7.8052 (3.1); 7.7775 (1.9); 7.7323 (3.2); 7.7046 (2.5); 5.3178 (0.7); 5.2951 (1.2); 5.2725 (0.7); 3.8882 (1.2); 3.8292 (16.0); 3.6169 (0.9); 3.5696 (1.7); 3.3367 (21.9); 3.3135 (0.5); 2.5166 (3.4); 2.5108 (6.8); 2.5049 (9.0); 2.4990 (6.2); 1.5284 (0.3); 1.4968 (4.6); 1.4739 (4.5); -0.0002 (5.2) I.2-178: 1H-NMR(300.0 MHz, d6-DMSO): δ= 13.5115 (0.9); 13.4382 (0.4); 9.2017 (4.6); 9.1802 (4.8); 8.6875 (7.4); 8.6794 (12.8); 8.6593 (13.1); 8.6513 (8.4); 8.0563 (9.0); 8.0492 (9.8); 7.9326 (8.0); 7.9219 (7.5); 7.8938 (6.7); 7.8874 (5.8); 7.8756 (4.6); 7.8683 (4.1); 7.8480 (5.7); 7.8406 (5.6); 7.7973 (10.2); 7.7696 (6.8); 7.6978 (10.1); 7.6701 (7.6); 5.3422 (0.6); 5.3196 (2.6); 5.2969 (4.1); 5.2741 (2.7); 5.2516 (0.7); 3.3272 (10.6); 2.5102 (20.4); 2.5045 (26.8); 2.4992 (19.9); 1.4897 (16.0); 1.4668 (15.8); 1.2321 (1.0); -0.0001 (12.0) BCS241005-Ausland STR 235 I.2-179: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.1431 (4.5); 9.1217 (4.6); 8.6823 (7.8); 8.6743 (13.2); 8.6550 (13.7); 8.6470 (8.4); 8.6287 (0.4); 8.1130 (9.8); 8.1061 (10.3); 8.0415 (8.4); 8.0343 (9.1); 7.8897 (4.6); 7.8827 (4.4); 7.8609 (6.4); 7.8544 (9.0); 7.8489 (4.8); 7.8280 (5.4); 7.8207 (5.3); 7.6885 (10.0); 7.6610 (7.4); 7.6439 (4.7); 7.6395 (5.0); 7.6154 (3.9); 7.6109 (4.0); 5.3269 (0.6); 5.3045 (2.7); 5.2819 (4.1); 5.2595 (2.7); 5.2387 (0.6); 3.6134 (0.4); 3.5908 (0.3); 3.5095 (4.4); 3.4635 (0.8); 3.3276 (6.2); 2.5092 (26.4); 2.5035 (34.7); 2.4977 (24.8); 1.9110 (0.4); 1.4809 (16.0); 1.4581 (15.7); 1.2577 (0.3); 1.2378 (0.6); -0.0002 (13.0) I.2-180: 1H-NMR(400.1 MHz, d6-DMSO): δ= 9.1468 (1.6); 9.1303 (1.7); 8.6177 (15.4); 8.1501 (3.7); 8.1448 (3.7); 7.9591 (3.2); 7.9532 (3.6); 7.9155 (1.8); 7.9102 (1.7); 7.8940 (2.2); 7.8887 (2.2); 7.8828 (1.8); 7.8768 (1.5); 7.8612 (1.8); 7.8553 (1.6); 7.6556 (1.6); 7.6522 (1.6); 7.6340 (1.4); 7.6307 (1.3); 7.2907 (2.9); 7.2689 (2.6); 5.3677 (1.0); 5.3508 (1.5); 5.3339 (1.0); 3.8960 (16.0); 3.3419 (1.7); 2.5157 (2.2); 2.5113 (4.3); 2.5069 (5.7); 2.5024 (4.0); 2.4981 (1.8); 2.0800 (0.4); 1.4702 (5.7); 1.4530 (5.6); - 0.0002 (2.2) I.2-181: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6402 (1.0); 8.6351 (1.1); 8.5724 (1.3); 8.5670 (1.2); 8.1952 (1.7); 8.1906 (1.7); 7.7260 (0.8); 7.7213 (0.8); 7.7092 (1.6); 7.7057 (3.0); 7.7015 (2.2); 7.5670 (1.4); 7.4492 (1.4); 7.4295 (1.2); 7.3739 (1.4); 7.3715 (1.6); 7.2623 (7.1); 5.6746 (0.6); 5.6576 (0.7); 5.6386 (0.6); 5.2998 (8.9); 3.9037 (16.0); 2.7051 (9.3); 1.6318 (0.7); 1.4554 (4.6); 1.4388 (4.6); -0.0002 (10.8) I.2-182: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6407 (0.9); 8.6352 (1.0); 8.5726 (1.2); 8.5670 (1.0); 8.1954 (1.7); 8.1905 (1.7); 7.7260 (0.9); 7.7210 (0.9); 7.7094 (1.5); 7.7057 (3.1); 7.7014 (2.3); 7.5670 (1.3); 7.4492 (1.4); 7.4295 (1.2); 7.3740 (1.4); 7.3716 (1.5); 7.3568 (0.5); 7.2622 (6.7); 5.6747 (0.6); 5.6577 (0.7); 5.6385 (0.6); 5.2998 (10.2); 3.9037 (16.0); 2.7051 (9.0); 1.6347 (1.0); 1.4554 (5.0); 1.4388 (5.0); - 0.0002 (10.0) I.2-183: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6351 (1.2); 8.6293 (1.4); 8.5564 (1.6); 8.5505 (1.4); 8.1976 (1.8); 8.1927 (1.8); 7.8120 (1.1); 7.8083 (1.4); 7.8046 (1.1); 7.7338 (0.9); 7.7288 (0.9); 7.7141 (1.1); 7.7092 (1.0); 7.6761 (1.0); 7.6711 (1.0); 7.6552 (1.5); 7.6503 (1.4); 7.5603 (2.7); 7.5395 (1.9); 7.4484 (1.4); 7.4287 (1.2); 7.3870 (0.5); 7.3677 (0.6); 7.2620 (7.2); 5.6843 (0.6); 5.6672 (0.8); 5.6482 (0.6); 5.2997 (4.9); 3.9013 (16.0); 2.7037 (9.2); 1.6301 (0.8); 1.4553 (5.1); 1.4386 (5.0); -0.0002 (10.6) I.2-184: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.2840 (1.4); 9.2620 (1.5); 8.7065 (2.6); 8.6984 (4.1); 8.6746 (4.3); 8.6665 (2.8); 8.3019 (2.0); 8.2972 (3.6); 8.2923 (2.2); 8.1844 (3.0); 8.1795 (1.9); 8.0950 (1.7); 8.0887 (3.1); 8.0835 (2.3); 8.0563 (2.5); 8.0506 (4.0); 8.0452 (3.1); 8.0199 (1.7); 8.0154 (1.3); 7.9899 (1.4); 7.9684 (1.3); 7.9635 (1.6); 7.6909 (1.5); 7.6651 (2.6); 7.6393 (1.2); 5.3431 (0.8); 5.3206 (1.3); 5.2980 (0.9); 3.8209 (16.0); 3.3307 (26.6); 2.6081 (15.4); 2.5148 (11.7); 2.5093 (23.2); 2.5034 (30.7); 2.4976 (22.3); 1.5114 (5.0); 1.4885 (5.0); 0.0107 (0.8); -0.0002 (19.8); -0.0111 (0.8) BCS241005-Ausland STR 236 I.2-185: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.0584 (3.5); 9.0393 (3.6); 8.7119 (10.1); 8.7043 (13.6); 8.6700 (11.1); 8.1349 (1.3); 8.0303 (0.8); 8.0121 (0.6); 7.9843 (0.8); 7.9790 (0.8); 7.8968 (15.5); 7.8853 (12.2); 7.8561 (11.6); 7.8508 (10.4); 7.8206 (1.8); 7.7970 (16.0); 7.7693 (8.5); 7.7238 (0.6); 7.5539 (0.4); 7.5308 (0.7); 7.5034 (1.1); 7.4790 (8.5); 7.4525 (7.4); 4.9871 (3.0); 3.9842 (0.3); 3.9635 (2.6); 3.8487 (3.7); 3.8362 (3.2); 3.7914 (4.1); 3.5123 (3.5); 3.4153 (0.3); 3.3962 (0.4); 3.3717 (0.3); 3.3288 (58.6); 3.3043 (1.4); 2.6924 (0.5); 2.5062 (27.7); 2.2733 (0.4); 2.1472 (11.6); 2.0646 (1.1); 1.5381 (0.8); 1.5144 (0.9); 1.4765 (2.2); 1.4296 (10.3); 1.4129 (10.1); 1.2355 (0.6); 1.1976 (0.4); 1.1641 (0.4); 1.1309 (0.4); 1.1101 (0.4); 1.1012 (0.4); -0.0001 (10.1) I.2-186: 1H-NMR(300.0 MHz, d6-DMSO): δ= 13.0416 (0.4); 13.0272 (0.5); 12.9659 (0.5); 12.9401 (0.6); 12.9074 (0.5); 12.8257 (0.4); 12.7992 (0.4); 9.0358 (3.7); 9.0126 (3.8); 8.9600 (0.4); 8.6902 (10.4); 8.6822 (16.0); 8.6557 (12.8); 8.6480 (9.3); 8.0991 (10.5); 8.0935 (11.1); 8.0167 (0.5); 8.0008 (0.5); 7.9803 (0.6); 7.9292 (6.0); 7.9015 (6.8); 7.8803 (6.8); 7.8736 (6.6); 7.8517 (8.1); 7.8450 (8.2); 7.7730 (0.7); 7.7111 (0.4); 7.6416 (6.8); 7.6145 (5.5); 7.4750 (9.1); 7.4482 (8.0); 4.9533 (2.0); 3.9637 (0.5); 3.5333 (0.4); 3.5092 (0.6); 3.4912 (0.4); 3.3272 (6.6); 3.1488 (0.4); 2.7240 (0.5); 2.5035 (51.7); 2.2661 (0.7); 2.1609 (8.1); 2.0192 (0.3); 1.4038 (7.6); 1.2755 (0.4); 1.2328 (0.5); 0.0690 (0.5); -0.0001 (23.2) I.2-187: 1H-NMR(400.1 MHz, d6-DMSO): δ= 12.8036 (0.4); 12.7800 (0.5); 12.7048 (1.7); 8.8769 (8.0); 8.8592 (7.5); 8.6524 (8.1); 8.6305 (10.7); 8.1621 (0.3); 8.1197 (0.6); 8.0623 (1.0); 7.9834 (4.4); 7.9597 (4.5); 7.9425 (5.8); 7.8981 (5.5); 7.8243 (0.9); 7.8012 (1.3); 7.7623 (3.1); 7.7410 (3.2); 7.6181 (0.9); 7.5688 (3.5); 7.5498 (2.8); 7.2616 (0.3); 7.2211 (4.9); 7.1993 (5.0); 5.2053 (0.6); 5.1913 (0.6); 5.0730 (0.4); 5.0183 (2.6); 3.9633 (1.3); 3.8302 (16.0); 3.8071 (3.2); 3.7218 (1.1); 3.6736 (2.4); 3.5090 (0.3); 3.4069 (0.5); 3.3332 (59.6); 3.2502 (0.4); 2.6723 (0.5); 2.5078 (55.8); 2.5035 (74.6); 2.4992 (54.2); 2.3305 (0.4); 2.0765 (0.6); 1.4962 (9.1); 1.4814 (9.4); 1.4335 (1.2); 1.4062 (0.6); 1.3198 (2.2); 1.2361 (0.4); 0.0078 (1.4); -0.0002 (34.7) I.2-188: 1H-NMR(300.0 MHz, d6-DMSO): δ= 8.8357 (5.0); 8.8117 (5.0); 8.6647 (9.0); 8.6403 (13.0); 8.6323 (8.8); 8.2109 (0.5); 8.1305 (0.4); 8.0755 (0.4); 7.9687 (3.1); 7.9396 (3.0); 7.8888 (4.6); 7.8604 (5.1); 7.7301 (2.2); 7.7095 (2.8); 7.5764 (3.2); 7.5508 (2.1); 7.2349 (5.2); 7.2058 (4.9); 5.1993 (0.5); 5.1650 (0.5); 5.0842 (1.6); 5.0641 (2.0); 3.9976 (0.3); 3.9128 (0.4); 3.8412 (12.5); 3.7411 (16.0); 3.5081 (0.4); 3.3244 (83.2); 3.3002 (2.6); 2.5853 (0.4); 2.5030 (44.0); 1.6259 (0.4); 1.5957 (0.5); 1.5031 (7.1); 1.4834 (7.3); 1.4151 (1.1); 1.3919 (1.3); 1.3382 (1.5); 1.2718 (0.6); 1.2578 (0.7); 1.2332 (1.8); 0.9125 (0.5); 0.8525 (0.4); 0.8272 (0.4); -0.0002 (16.0) I.2-189: 1H-NMR(400.1 MHz, d6-DMSO): δ= 9.0786 (1.2); 9.0648 (1.3); 8.6922 (4.8); 8.6861 (6.5); 8.6576 (4.2); 8.6518 (3.3); 7.9144 (5.7); 7.8940 (4.5); 7.8893 (3.9); 7.8731 (4.1); 7.8683 (3.5); 7.7904 BCS241005-Ausland STR 237 (5.9); 7.7694 (4.1); 7.4531 (2.0); 7.4334 (1.8); 4.9806 (0.7); 3.5080 (1.7); 3.3316 (35.8); 2.5117 (15.0); 2.5074 (30.6); 2.5029 (40.9); 2.4985 (29.0); 2.4941 (13.5); 2.1518 (2.2); 2.0762 (16.0); 1.4125 (1.9); 0.0080 (0.7); -0.0002 (17.9); -0.0084 (0.6) I.2-190: 1H-NMR(400.1 MHz, d6-DMSO): δ= 12.7726 (0.4); 12.7018 (1.3); 8.9265 (9.1); 8.9088 (9.0); 8.6555 (8.1); 8.6328 (11.1); 8.1587 (0.6); 7.9667 (3.9); 7.9484 (4.1); 7.8782 (6.4); 7.7934 (7.2); 7.7611 (5.0); 7.7186 (4.7); 7.6986 (2.6); 7.2169 (3.9); 7.1954 (4.2); 5.2260 (0.6); 5.0863 (0.5); 5.0402 (2.6); 3.8898 (0.4); 3.8290 (16.0); 3.7706 (0.7); 3.7493 (0.5); 3.6394 (2.4); 3.4249 (0.4); 3.3352 (40.2); 2.6735 (0.4); 2.5403 (0.5); 2.5084 (49.5); 2.5040 (66.2); 2.4997 (47.2); 2.3303 (0.4); 2.0773 (0.4); 1.5027 (9.1); 1.4877 (9.2); 1.3308 (2.0); 0.0079 (1.2); -0.0001 (35.3); -0.0084 (1.2) I.2-191: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6263 (1.5); 8.6205 (1.8); 8.5757 (2.1); 8.5699 (1.7); 8.3527 (1.2); 8.3487 (2.1); 8.3446 (1.2); 8.1977 (0.7); 8.1947 (1.1); 8.1782 (0.8); 8.1750 (1.2); 7.9937 (0.9); 7.9742 (1.0); 7.9417 (2.4); 7.9366 (2.4); 7.6846 (1.1); 7.6794 (1.0); 7.6728 (1.2); 7.6638 (1.5); 7.6586 (1.5); 7.6534 (2.1); 7.6339 (1.0); 7.5497 (2.8); 7.5289 (2.1); 7.2614 (29.3); 7.1659 (0.6); 7.1427 (0.6); 5.5499 (0.8); 5.5310 (1.0); 5.5271 (1.0); 5.5084 (0.8); 3.9557 (16.0); 2.0107 (0.7); 1.9932 (0.7); 1.5750 (14.2); 0.8808 (5.3); 0.8640 (5.1); 0.6438 (5.0); 0.6269 (4.9); 0.0079 (1.1); -0.0002 (33.2); -0.0085 (0.9) I.2-192: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6255 (1.0); 8.6203 (1.1); 8.5759 (1.4); 8.5702 (1.2); 8.3531 (1.1); 8.3491 (1.9); 8.3451 (1.1); 8.1978 (0.7); 8.1946 (1.0); 8.1910 (0.7); 8.1783 (0.8); 8.1749 (1.1); 8.1714 (0.7); 7.9973 (0.6); 7.9940 (0.9); 7.9901 (0.6); 7.9781 (0.7); 7.9744 (1.0); 7.9709 (0.7); 7.9418 (2.4); 7.9367 (2.5); 7.6845 (1.2); 7.6793 (1.2); 7.6727 (1.1); 7.6637 (1.6); 7.6585 (1.6); 7.6533 (2.0); 7.6339 (0.9); 7.5490 (2.9); 7.5282 (2.1); 7.2624 (10.2); 7.1668 (0.6); 7.1445 (0.6); 5.5498 (0.8); 5.5311 (1.0); 5.5269 (0.9); 5.5082 (0.8); 3.9557 (16.0); 2.0104 (0.7); 1.9930 (0.7); 1.6113 (4.6); 0.8808 (5.2); 0.8639 (5.0); 0.6437 (4.8); 0.6268 (4.7); -0.0002 (11.9) I.2-193: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6306 (2.4); 8.6246 (3.2); 8.5849 (2.7); 8.5789 (2.1); 8.3719 (1.1); 8.3678 (1.9); 8.3640 (1.1); 8.1917 (0.7); 8.1883 (1.0); 8.1845 (0.8); 8.1721 (0.8); 8.1683 (1.1); 8.1650 (0.8); 8.0198 (1.5); 8.0161 (2.8); 8.0124 (1.6); 7.9837 (0.7); 7.9794 (0.9); 7.9763 (0.7); 7.9646 (0.8); 7.9603 (1.0); 7.9572 (0.7); 7.8439 (1.4); 7.8395 (2.2); 7.8355 (1.5); 7.7584 (1.6); 7.7541 (2.2); 7.7499 (1.4); 7.6468 (1.0); 7.6275 (1.8); 7.6081 (0.8); 7.2606 (56.4); 7.2182 (0.6); 7.1990 (0.5); 5.1087 (0.8); 5.0880 (1.5); 5.0673 (0.8); 3.9526 (16.0); 3.4948 (1.0); 1.5516 (8.0); 1.2093 (0.6); 1.1887 (0.6); 0.3776 (0.6); 0.3366 (0.6); 0.3245 (0.6); 0.0583 (0.5); 0.0468 (0.5); 0.0348 (0.5); 0.0223 (0.5); 0.0080 (2.1); -0.0002 (66.6); -0.0085 (1.7) I.2-194: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6313 (2.2); 8.6252 (2.8); 8.5849 (2.5); 8.5788 (2.0); 8.3723 (1.0); 8.3683 (2.0); 8.3644 (1.1); 8.1916 (0.7); 8.1883 (1.0); 8.1846 (0.8); 8.1721 (0.8); 8.1685 (1.1); BCS241005-Ausland STR 238 8.1650 (0.8); 8.0205 (1.4); 8.0168 (2.8); 8.0131 (1.6); 7.9852 (0.7); 7.9820 (0.9); 7.9778 (0.7); 7.9660 (0.8); 7.9619 (1.0); 7.9587 (0.8); 7.8430 (1.4); 7.8387 (2.2); 7.8346 (1.5); 7.7592 (1.5); 7.7550 (2.3); 7.7507 (1.4); 7.6471 (1.0); 7.6278 (1.8); 7.6086 (0.9); 7.2613 (20.9); 7.2292 (0.5); 7.2100 (0.6); 5.1071 (0.8); 5.0864 (1.5); 5.0658 (0.8); 3.9526 (16.0); 3.4925 (6.2); 1.5720 (1.3); 1.2098 (0.6); 1.1893 (0.6); 0.3774 (0.6); 0.3368 (0.6); 0.3246 (0.6); 0.0462 (0.5); 0.0319 (0.6); 0.0080 (0.8); -0.0002 (24.5); -0.0085 (0.8) I.2-195: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6313 (1.1); 8.6253 (1.4); 8.5850 (1.5); 8.5790 (1.2); 8.3726 (0.7); 8.3684 (1.4); 8.3644 (0.8); 8.1890 (0.7); 8.1727 (0.5); 8.1691 (0.8); 8.1657 (0.5); 7.9782 (0.6); 7.9623 (0.5); 7.9582 (0.7); 7.8807 (3.7); 7.8764 (4.1); 7.8065 (1.1); 7.8022 (1.9); 7.7978 (0.9); 7.6479 (0.7); 7.6285 (1.3); 7.6091 (0.6); 7.2611 (24.2); 5.1135 (0.6); 5.0928 (1.1); 5.0722 (0.6); 3.9530 (10.9); 1.5601 (16.0); 0.0079 (0.9); -0.0002 (27.7); -0.0085 (0.8) I.2-196: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6311 (0.7); 8.6250 (0.9); 8.5848 (0.8); 8.5788 (0.6); 8.3682 (0.6); 7.8806 (1.6); 7.8762 (1.8); 7.8022 (0.8); 7.6283 (0.5); 7.2610 (11.5); 3.9530 (4.7); 1.5588 (16.0); - 0.0002 (13.3) I.2-200: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1701 (1.7); 9.1525 (1.7); 8.6905 (3.9); 8.6845 (6.1); 8.6652 (7.0); 8.6591 (4.7); 8.2043 (2.1); 8.2003 (3.7); 8.1965 (2.1); 8.0688 (1.3); 8.0658 (1.9); 8.0618 (1.3); 8.0494 (1.5); 8.0463 (2.0); 8.0424 (1.5); 8.0136 (2.9); 8.0095 (6.2); 8.0055 (4.3); 8.0018 (1.3); 7.9900 (1.5); 7.9856 (1.8); 7.9826 (1.2); 7.7604 (5.1); 7.7583 (6.5); 7.7566 (6.0); 7.7545 (4.7); 7.6865 (1.9); 7.6673 (3.3); 7.6480 (1.5); 5.1685 (0.5); 5.1531 (0.9); 5.1361 (0.9); 5.1318 (0.9); 5.1148 (0.5); 4.0566 (1.1); 4.0389 (3.4); 4.0211 (3.5); 4.0034 (1.1); 3.6019 (0.5); 3.3258 (15.1); 2.6721 (0.6); 2.5258 (1.7); 2.5211 (2.6); 2.5123 (35.0); 2.5078 (74.6); 2.5032 (102.7); 2.4986 (70.3); 2.4941 (30.6); 2.3348 (0.5); 2.3303 (0.7); 1.9897 (16.0); 1.9666 (0.5); 1.9500 (0.7); 1.9294 (0.8); 1.9103 (7.2); 1.8864 (0.6); 1.8712 (0.8); 1.8526 (1.0); 1.8340 (0.5); 1.7602 (0.6); 1.3562 (1.2); 1.1932 (4.5); 1.1754 (9.0); 1.1577 (4.4); 0.8098 (3.4); 0.7916 (7.6); 0.7732 (3.1); 0.0080 (2.0); -0.0002 (66.4); -0.0085 (1.9) I.2-201: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4422 (4.3); 9.4257 (4.4); 8.7055 (10.2); 8.6994 (14.0); 8.6714 (16.0); 8.6653 (11.8); 8.2215 (5.0); 8.2174 (8.9); 8.2136 (5.0); 8.0556 (2.7); 8.0526 (4.5); 8.0482 (3.9); 8.0442 (4.4); 8.0402 (5.6); 8.0366 (11.3); 8.0325 (14.0); 8.0286 (9.8); 8.0247 (5.1); 8.0206 (5.4); 8.0177 (2.7); 7.7852 (6.3); 7.7827 (6.3); 7.7684 (5.4); 7.7659 (6.1); 7.6540 (4.5); 7.6348 (8.0); 7.6154 (3.8); 4.6665 (2.9); 4.6501 (3.2); 4.6434 (3.2); 4.6268 (3.0); 4.0568 (0.7); 4.0390 (2.3); 4.0213 (2.3); 4.0035 (0.8); 3.8447 (1.1); 3.6020 (0.6); 3.5695 (0.5); 3.3262 (15.5); 2.6768 (0.8); 2.6723 (1.2); 2.6676 (0.8); 2.5260 (3.8); 2.5214 (5.1); 2.5125 (65.9); 2.5080 (141.4); 2.5035 (194.9); 2.4989 (133.8); 2.4943 (58.4); 2.3351 (1.0); 2.3306 (1.2); 2.3260 (0.8); 2.2011 (1.0); 2.1840 (0.5); 1.9899 (10.5); 1.9106 (9.8); 1.7601 (0.7); 1.3660 (0.9); 1.3564 (5.4); 1.3459 (1.8); 1.3346 (1.7); 1.3231 (1.8); 1.3139 (1.1); 1.3029 BCS241005-Ausland STR 239 (0.8); 1.2336 (0.8); 1.1933 (3.0); 1.1755 (6.0); 1.1577 (2.8); 0.5405 (0.6); 0.5264 (0.9); 0.5180 (1.5); 0.5066 (2.0); 0.4980 (1.5); 0.4947 (1.5); 0.4837 (1.2); 0.4730 (0.8); 0.4111 (0.7); 0.3970 (1.3); 0.3857 (1.6); 0.3764 (2.0); 0.3653 (1.6); 0.3540 (1.0); 0.3432 (0.6); 0.2894 (0.8); 0.2776 (1.6); 0.2658 (2.2); 0.2539 (2.2); 0.2404 (1.5); 0.2286 (0.6); 0.0080 (3.9); -0.0002 (130.9); -0.0085 (3.4); -0.1275 (0.7); - 0.1398 (1.7); -0.1509 (2.3); -0.1634 (2.1); -0.1765 (1.4); -0.1881 (0.6) I.2-206: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6161 (2.2); 8.6101 (2.8); 8.5662 (2.4); 8.5601 (1.9); 7.7145 (1.3); 7.7105 (2.2); 7.7064 (1.4); 7.6045 (2.4); 7.5992 (2.6); 7.5645 (1.3); 7.5624 (1.2); 7.4742 (2.1); 7.4689 (1.9); 7.3789 (0.9); 7.3763 (1.2); 7.3743 (1.2); 7.3053 (0.5); 7.2852 (0.5); 7.2665 (3.2); 5.7446 (0.6); 5.7277 (0.6); 5.7249 (0.7); 5.7079 (0.6); 3.9950 (16.0); 3.9858 (12.2); 3.9226 (14.3); 1.7052 (0.9); 1.4620 (4.4); 1.4453 (4.4); 0.9009 (0.8); -0.0002 (3.8) I.2-211: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6223 (2.1); 8.6162 (3.1); 8.5951 (2.9); 8.5891 (1.9); 7.9371 (2.5); 7.9318 (2.6); 7.6967 (1.3); 7.6928 (2.3); 7.6887 (1.4); 7.6156 (2.2); 7.6104 (2.1); 7.5423 (1.4); 7.3695 (1.3); 7.2627 (9.0); 7.2427 (0.7); 5.6535 (0.6); 5.6364 (0.8); 5.6338 (0.8); 5.6167 (0.7); 4.1838 (16.0); 4.0357 (13.0); 3.7483 (0.8); 1.8544 (1.0); 1.5052 (5.0); 1.4884 (5.0); -0.0002 (10.0) I.2-212: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6116 (2.2); 8.6056 (2.8); 8.5666 (2.5); 8.5606 (2.0); 7.6692 (5.2); 7.6645 (5.4); 7.5999 (2.4); 7.5946 (2.6); 7.5006 (1.4); 7.4960 (2.5); 7.4912 (1.3); 7.4728 (2.2); 7.4676 (2.0); 7.2612 (21.7); 7.2436 (0.6); 7.2229 (0.6); 5.7375 (0.6); 5.7206 (0.7); 5.7174 (0.7); 5.7006 (0.6); 3.9942 (16.0); 3.9857 (12.8); 3.9220 (14.6); 1.5973 (2.9); 1.4519 (4.8); 1.4352 (4.8); 1.3036 (0.7); 1.2861 (0.9); 1.2644 (3.3); 0.8987 (1.7); 0.8820 (5.2); 0.8643 (2.1); 0.0079 (0.9); -0.0002 (26.5); -0.0084 (0.8) I.2-213: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6064 (2.2); 8.6004 (2.8); 8.5551 (2.4); 8.5490 (1.9); 7.9064 (2.1); 7.9013 (2.2); 7.6467 (1.0); 7.6415 (1.0); 7.6259 (1.4); 7.6207 (1.4); 7.6054 (2.4); 7.6001 (2.6); 7.5276 (2.6); 7.5068 (1.8); 7.4820 (2.0); 7.4767 (1.8); 7.2816 (0.5); 7.2691 (2.2); 7.2615 (0.5); 5.7436 (0.6); 5.7268 (0.6); 5.7238 (0.6); 5.7068 (0.6); 3.9925 (16.0); 3.9838 (11.8); 3.9193 (14.4); 1.4556 (4.3); 1.4389 (4.3); -0.0002 (2.5) I.2-214: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6159 (0.8); 8.6099 (1.0); 8.5670 (0.9); 8.5610 (0.7); 7.7055 (0.8); 7.7015 (0.5); 7.6019 (0.9); 7.5966 (1.0); 7.5598 (0.5); 7.4676 (0.8); 7.4624 (0.7); 7.2604 (25.0); 3.9949 (6.0); 3.9850 (4.7); 3.9226 (5.5); 1.5530 (16.0); 1.4611 (1.7); 1.4444 (1.7); 0.0079 (0.8); -0.0002 (29.3); -0.0085 (0.9) I.2-215: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6071 (3.4); 8.6031 (4.1); 8.5630 (3.6); 8.5590 (3.1); 7.8574 (7.3); 7.8546 (8.1); 7.8019 (2.2); 7.7990 (3.7); 7.7961 (1.8); 7.5955 (3.5); 7.5919 (3.7); 7.4723 (3.1); BCS241005-Ausland STR 240 7.4688 (2.9); 7.2604 (41.5); 7.2164 (0.9); 7.2031 (0.9); 5.7257 (0.9); 5.7144 (1.1); 5.7125 (1.0); 5.7012 (0.9); 5.2984 (13.9); 3.9927 (22.6); 3.9845 (18.2); 3.9210 (20.9); 2.0044 (2.4); 1.5814 (0.4); 1.5599 (50.0); 1.5414 (0.6); 1.4469 (6.9); 1.4357 (7.0); 1.2539 (0.4); 1.2152 (0.5); 1.2050 (0.5); 0.0053 (1.4); - 0.0001 (38.1); -0.0056 (1.3) I.2-216: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6284 (2.2); 8.6223 (2.7); 8.5738 (2.3); 8.5678 (1.9); 8.2472 (2.8); 8.0205 (1.2); 7.6154 (2.4); 7.6101 (2.5); 7.4825 (1.9); 7.4773 (1.8); 7.2614 (22.1); 5.7907 (0.5); 5.7737 (0.6); 5.7539 (0.5); 3.9999 (16.0); 3.9936 (11.9); 3.9279 (14.4); 1.5773 (5.0); 1.4927 (4.3); 1.4759 (4.3); 0.0079 (0.8); -0.0002 (27.2); -0.0085 (0.7) I.2-217: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6158 (2.2); 8.6098 (2.8); 8.5679 (2.3); 8.5618 (1.9); 7.8559 (1.2); 7.8520 (2.2); 7.8481 (1.3); 7.6019 (3.4); 7.5966 (3.1); 7.5274 (1.1); 7.4690 (1.9); 7.4637 (1.8); 7.2611 (31.4); 7.2469 (0.6); 5.7415 (0.5); 5.7246 (0.6); 5.7218 (0.6); 5.7048 (0.5); 3.9948 (16.0); 3.9849 (11.8); 3.9225 (14.5); 1.5675 (8.3); 1.4609 (4.2); 1.4442 (4.2); 0.0079 (1.0); -0.0002 (37.6); -0.0085 (1.2) I.2-223: 1H-NMR(400.6 MHz, CDCl3): δ= 8.5995 (1.6); 8.5898 (1.6); 8.5479 (1.2); 8.5421 (1.4); 8.5026 (1.4); 8.4968 (1.1); 8.2769 (1.2); 8.2605 (1.2); 8.1386 (0.8); 8.0200 (0.8); 7.9107 (0.6); 7.8949 (1.1); 7.8759 (0.7); 7.6972 (0.8); 7.6730 (1.7); 7.6544 (1.1); 7.6453 (1.3); 7.6265 (1.2); 7.6120 (1.4); 7.5945 (1.3); 7.5756 (0.5); 7.3793 (1.0); 7.3566 (1.1); 7.3486 (1.3); 7.3262 (1.3); 7.2605 (48.6); 5.3175 (1.0); 5.3000 (9.1); 4.0198 (0.9); 3.9758 (1.0); 3.9381 (6.4); 3.9255 (7.0); 3.8837 (1.0); 3.8402 (1.3); 3.7762 (8.0); 3.7671 (16.0); 3.3805 (1.0); 3.3705 (1.1); 3.3371 (0.9); 3.3267 (1.0); 2.9566 (5.3); 2.8844 (4.9); 2.1717 (0.8); 1.8532 (0.7); 1.7460 (6.1); 1.6667 (5.2); 1.5580 (8.1); 1.2535 (0.6); 0.7645 (1.4); 0.7461 (2.8); 0.7275 (1.3); 0.6935 (1.3); 0.6752 (2.5); 0.6566 (1.1); -0.0002 (60.8); -0.0083 (3.3) I.2-224: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6421 (1.0); 8.6361 (1.2); 8.5992 (1.2); 8.5932 (0.9); 8.4442 (0.8); 8.4241 (0.8); 8.3186 (0.9); 8.2829 (1.9); 8.1991 (0.5); 8.1794 (0.5); 7.9333 (0.5); 7.6468 (0.9); 7.4718 (0.9); 7.4494 (0.9); 7.2601 (38.9); 3.9525 (5.6); 3.7898 (11.3); 1.5400 (16.0); 0.8076 (1.1); 0.7892 (2.3); 0.7706 (1.0); -0.0002 (48.7); -0.0083 (2.6) I.2-225: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6461 (2.8); 8.6401 (3.5); 8.6021 (3.5); 8.5962 (2.7); 8.4875 (0.7); 8.3880 (2.3); 8.3689 (2.4); 8.3200 (3.0); 8.2813 (5.4); 8.2002 (1.5); 8.1805 (1.7); 8.0242 (0.8); 7.9610 (1.3); 7.9424 (1.6); 7.6684 (1.4); 7.6491 (2.5); 7.6295 (1.3); 7.4646 (2.5); 7.4426 (2.6); 7.2617 (63.2); 7.1209 (1.3); 7.0995 (1.4); 6.3870 (5.1); 5.5902 (1.0); 5.5719 (1.0); 5.5521 (0.5); 3.9527 (16.0); 3.7501 (0.5); 3.5751 (9.3); 2.9611 (5.2); 2.8883 (4.8); 1.8722 (1.0); 1.8556 (1.7); 1.8387 (1.5); 1.8208 (1.6); 1.8022 (1.6); 1.7844 (1.2); 1.7673 (0.8); 1.2534 (0.7); 0.8089 (3.1); 0.7904 (6.6); 0.7720 (2.9); - 0.0002 (78.0) BCS241005-Ausland STR 241 I.3-1: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5808 (1.5); 8.5744 (3.9); 8.5675 (4.1); 8.5611 (1.6); 8.1470 (1.2); 8.1443 (1.2); 8.1274 (1.3); 8.1246 (1.3); 7.7213 (0.6); 7.7180 (0.6); 7.7025 (1.4); 7.6992 (1.4); 7.6896 (1.5); 7.6853 (2.8); 7.6813 (2.2); 7.6071 (0.8); 7.6039 (0.9); 7.5878 (1.3); 7.5846 (1.4); 7.5687 5 (0.6); 7.5655 (0.6); 7.5441 (1.6); 7.4900 (1.2); 7.4711 (1.0); 7.4284 (0.6); 7.4091 (0.6); 7.3602 (1.5); 7.2609 (9.0); 5.2992 (0.7); 5.2811 (0.9); 5.2634 (0.7); 3.6571 (16.0); 1.3711 (6.0); 1.3543 (5.9); 1.2645 (1.6); 0.8987 (0.8); 0.8819 (2.5); 0.8643 (1.0); -0.0002 (12.7) I.3-2: 1H-NMR (400.6 MHz, d6-DMSO3): δ= 12.7619 (0.9); 9.0751 (1.9); 9.0579 (1.9); 8.6062 (8.6); 10 8.5999 (10.1); 8.5357 (12.0); 8.5294 (10.4); 8.0050 (4.9); 8.0027 (3.3); 7.9857 (6.1); 7.9834 (4.0); 7.9781 (4.1); 7.9744 (6.0); 7.9706 (4.0); 7.9429 (0.6); 7.7817 (0.6); 7.7785 (0.6); 7.7758 (0.6); 7.7537 (5.5); 7.7512 (5.2); 7.7490 (5.0); 7.7465 (4.6); 7.7434 (5.1); 7.6493 (5.2); 7.6387 (8.2); 7.5921 (3.3); 7.5817 (2.1); 7.5728 (3.1); 7.5702 (2.3); 7.5618 (2.4); 7.5508 (1.9); 5.7577 (12.1); 5.1166 (1.8); 5.0995 (2.7); 5.0822 (1.8); 4.0387 (0.8); 4.0209 (0.8); 3.3225 (5.7); 2.6759 (0.7); 2.6714 (0.9); 2.6668 (0.7); 15 2.5251 (4.9); 2.5205 (6.0); 2.5117 (47.1); 2.5071 (97.1); 2.5025 (132.2); 2.4980 (91.0); 2.4934 (40.0); 2.3342 (0.6); 2.3296 (0.8); 2.3249 (0.5); 1.9894 (3.4); 1.9099 (1.2); 1.3570 (16.0); 1.3400 (13.6); 1.2700 (0.7); 1.2587 (0.6); 1.2340 (1.5); 1.1929 (1.4); 1.1818 (3.3); 1.1751 (2.7); 1.1701 (1.0); 1.1573 (1.2); 1.0740 (1.6); 1.0565 (3.2); 1.0390 (1.5); 0.8715 (0.6); 0.0080 (3.5); -0.0002 (104.6); -0.0085 (3.0) 20 I.3-3: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5711 (1.4); 8.5647 (4.1); 8.5590 (4.4); 8.5526 (1.5); 8.1498 (1.2); 8.1471 (1.2); 8.1303 (1.2); 8.1274 (1.2); 7.8896 (2.5); 7.8845 (2.6); 7.7184 (0.6); 7.7151 (0.6); 7.6996 (1.4); 7.6962 (1.4); 7.6808 (1.0); 7.6774 (0.9); 7.6300 (1.2); 7.6248 (1.1); 7.6092 (1.7); 7.6042 (2.2); 7.5857 (1.3); 7.5824 (1.4); 7.5666 (0.6); 7.5633 (0.6); 7.5167 (3.1); 7.4958 (3.2); 7.4762 (1.0); 7.4006 (0.6); 7.3809 (0.6); 7.2607 (14.0); 5.2967 (0.6); 5.2795 (0.8); 5.2609 (0.7); 3.6489 (16.0); 2.0455 25 (0.5); 1.3578 (5.9); 1.3410 (5.9); 0.0079 (0.6); -0.0002 (19.9); -0.0085 (0.6) I.3-4: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5810 (1.7); 8.5746 (3.5); 8.5631 (3.7); 8.5567 (1.8); 8.1483 (1.1); 8.1455 (1.1); 8.1287 (1.2); 8.1259 (1.2); 7.7190 (0.6); 7.7157 (0.6); 7.7002 (1.4); 7.6968 (1.4); 7.6813 (1.0); 7.6781 (0.9); 7.6503 (5.6); 7.6456 (5.8); 7.6060 (0.8); 7.6028 (0.9); 7.5867 (1.3); 7.5835 30 (1.4); 7.5677 (0.6); 7.5643 (0.6); 7.4840 (2.7); 7.4793 (3.1); 7.4746 (1.5); 7.4674 (1.0); 7.3822 (0.5); 7.3624 (0.6); 7.2605 (17.8); 5.2894 (0.7); 5.2722 (0.8); 5.2534 (0.7); 3.6575 (16.0); 2.0455 (0.7); 1.5647 (0.7); 1.3612 (5.9); 1.3445 (5.9); 1.2643 (1.0); 1.2597 (1.0); 0.8987 (0.5); 0.8820 (1.6); 0.8642 (0.7); 0.0079 (0.8); -0.0002 (25.3); -0.0085 (0.7) 35 I.3-5: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5908 (1.5); 8.5844 (3.8); 8.5768 (4.1); 8.5705 (1.6); 8.2182 (3.5); 8.1387 (1.2); 8.1359 (1.2); 8.1192 (1.3); 8.1163 (1.2); 8.0021 (1.6); 7.7305 (0.6); 7.7273 (0.6); 7.7118 (1.5); 7.7084 (1.4); 7.6929 (1.0); 7.6896 (0.9); 7.6117 (0.9); 7.6084 (0.9); 7.5924 (1.3); 7.5892 BCS241005-Ausland STR 242 (1.4); 7.5733 (0.6); 7.5700 (0.6); 7.5348 (0.6); 7.5187 (0.7); 7.4994 (1.2); 7.4806 (1.0); 7.2604 (29.5); 5.3518 (0.7); 5.3338 (0.9); 5.3159 (0.7); 3.6626 (16.0); 1.5556 (1.6); 1.4121 (5.8); 1.3954 (5.8); 0.0079 (1.4); -0.0002 (42.0); -0.0085 (1.1) 5 I.3-6: 1H-NMR (400.6 MHz, d6-DMSO): δ= 8.5978 (2.6); 8.5915 (3.0); 8.5264 (3.6); 8.5200 (3.1); 8.0787 (1.7); 8.0739 (1.7); 8.0024 (1.0); 7.9831 (1.1); 7.7957 (0.9); 7.7906 (0.8); 7.7748 (1.4); 7.7696 (1.4); 7.7221 (3.3); 7.7011 (2.0); 7.6567 (1.4); 7.6465 (2.1); 7.5943 (0.7); 7.5840 (0.6); 7.5748 (0.7); 7.5641 (0.6); 5.0975 (0.6); 5.0798 (0.9); 5.0627 (0.6); 4.0556 (0.8); 4.0378 (2.6); 4.0200 (2.6); 4.0023 (0.9); 3.3186 (16.0); 2.6745 (0.6); 2.6699 (0.8); 2.6653 (0.6); 2.5371 (0.8); 2.5324 (0.7); 2.5237 (2.2); 10 2.5190 (3.2); 2.5103 (46.3); 2.5057 (99.7); 2.5011 (137.9); 2.4966 (94.3); 2.4920 (41.3); 2.3328 (0.5); 2.3282 (0.8); 2.3236 (0.5); 1.9886 (11.9); 1.9084 (4.6); 1.3551 (1.0); 1.3423 (4.2); 1.3251 (4.1); 1.1922 (3.5); 1.1807 (1.1); 1.1744 (7.1); 1.1567 (3.4); 0.0080 (3.4); -0.0002 (126.8); -0.0060 (1.1); -0.0069 (1.0); -0.0085 (3.6) 15 I.3-7: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5906 (1.6); 8.5842 (3.9); 8.5766 (4.2); 8.5703 (1.7); 8.2178 (3.7); 8.1386 (1.2); 8.1358 (1.2); 8.1189 (1.3); 8.1161 (1.3); 8.0019 (1.6); 7.7304 (0.6); 7.7270 (0.6); 7.7115 (1.5); 7.7082 (1.5); 7.6927 (1.0); 7.6893 (0.9); 7.6114 (0.9); 7.6082 (1.0); 7.5921 (1.3); 7.5889 (1.4); 7.5730 (0.7); 7.5698 (0.7); 7.5359 (0.6); 7.5186 (0.7); 7.4996 (1.2); 7.4807 (1.0); 7.2605 (18.6); 5.3517 (0.7); 5.3335 (0.9); 5.3161 (0.7); 3.6626 (16.0); 1.5627 (0.6); 1.4121 (6.0); 1.3954 (5.9); 0.0079 20 (0.9); -0.0002 (22.5); -0.0085 (0.7) I.3-8: 1H-NMR(400.6 MHz, d6-DMSO): δ= 12.7626 (1.9); 9.3341 (2.6); 9.3171 (2.5); 8.6160 (8.8); 8.6097 (9.8); 8.5455 (11.3); 8.5392 (9.5); 8.4653 (13.1); 8.2935 (6.6); 8.0070 (5.3); 7.9877 (5.4); 7.6506 (7.7); 7.6391 (7.1); 7.6198 (1.1); 7.5890 (3.2); 7.5784 (2.5); 7.5696 (3.4); 7.5603 (1.8); 7.5477 (1.6); 25 6.8705 (0.6); 6.6265 (0.5); 5.1721 (2.0); 5.1546 (2.9); 5.1375 (1.9); 3.3206 (16.0); 2.6710 (1.7); 2.5110 (107.3); 2.5067 (196.5); 2.5022 (248.2); 2.4977 (171.6); 2.4934 (77.8); 2.3292 (1.4); 2.1839 (1.1); 1.9893 (0.7); 1.9094 (0.6); 1.3929 (15.3); 1.3756 (15.0); 1.3560 (8.2); 1.2694 (0.8); 1.2352 (1.1); 1.1814 (3.4); 1.1697 (1.2); 0.1458 (0.6); 0.0079 (8.2); -0.0002 (125.9); -0.0085 (4.6) 30 I.3-9: 1H-NMR(400.6 MHz, d6-DMSO): δ= 12.7653 (1.7); 9.3367 (2.6); 9.3198 (2.4); 8.6175 (6.6); 8.6115 (7.2); 8.5471 (7.8); 8.5413 (6.5); 8.4676 (12.1); 8.2936 (6.1); 8.0101 (4.5); 7.9906 (4.7); 7.6526 (7.2); 7.6412 (6.3); 7.6219 (1.4); 7.5906 (2.6); 7.5804 (2.4); 7.5704 (3.0); 7.5492 (1.3); 5.1752 (2.0); 5.1578 (2.7); 5.1410 (1.7); 4.0578 (1.6); 4.0397 (4.2); 4.0219 (4.0); 4.0043 (1.4); 3.6020 (0.5); 3.3255 (10.8); 2.6735 (1.9); 2.5075 (80.6); 2.5040 (93.0); 2.3324 (1.1); 2.1852 (0.7); 1.9903 (16.0); 1.7604 35 (0.5); 1.3955 (13.2); 1.3784 (12.4); 1.3582 (1.4); 1.2707 (0.6); 1.2343 (0.9); 1.1936 (4.8); 1.1758 (8.5); 1.1585 (4.2); -0.0002 (26.0) BCS241005-Ausland STR 243 I.3-10: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.5065 (0.8); 8.5002 (1.1); 8.4669 (1.6); 8.4606 (2.0); 8.2858 (0.5); 8.1131 (0.5); 7.7420 (0.7); 7.7286 (0.5); 5.2763 (1.5); 3.3209 (16.0); 2.5417 (0.5); 2.5247 (1.2); 2.5201 (1.4); 2.5113 (11.2); 2.5068 (22.8); 2.5022 (31.0); 2.4976 (21.4); 2.4931 (9.5); 2.0863 (5.4); 1.2648 (1.0); 1.2476 (1.0); -0.0002 (9.3) 5 I.3-11: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5934 (1.4); 8.5871 (4.0); 8.5808 (4.2); 8.5744 (1.5); 8.2212 (3.8); 8.1415 (1.2); 8.1390 (1.2); 8.1218 (1.3); 8.1188 (1.3); 8.0038 (1.7); 7.7336 (0.6); 7.7304 (0.6); 7.7148 (1.4); 7.7115 (1.5); 7.6960 (1.0); 7.6927 (1.0); 7.6146 (0.8); 7.6114 (1.0); 7.5952 (1.3); 7.5920 (1.4); 7.5762 (0.7); 7.5729 (0.7); 7.5499 (0.6); 7.5305 (0.6); 7.5018 (1.2); 7.4826 (1.0); 7.2618 (23.9); 10 5.3512 (0.7); 5.3332 (0.9); 5.3155 (0.7); 3.6648 (16.0); 2.1748 (1.6); 1.5801 (0.7); 1.4129 (6.0); 1.3962 (6.0); 1.2571 (0.6); 0.0080 (1.1); -0.0002 (34.6); -0.0085 (1.1) I.3-12: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6491 (1.5); 8.6428 (1.7); 8.5648 (1.9); 8.5585 (1.7); 8.4652 (1.8); 8.3063 (0.9); 7.9993 (0.9); 7.9971 (0.5); 7.9799 (0.9); 7.7100 (1.2); 7.6996 (1.1); 7.6967 15 (0.8); 7.6274 (0.5); 5.1717 (0.5); 3.5237 (5.7); 3.3356 (16.0); 2.5214 (0.8); 2.5126 (10.1); 2.5081 (21.6); 2.5036 (29.7); 2.4990 (20.6); 2.4945 (9.1); 2.0872 (1.4); 1.3857 (2.2); 1.3684 (2.2); 0.0079 (0.8); - 0.0002 (23.9); -0.0085 (0.7) I.3-13: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5635 (0.9); 8.5570 (4.5); 8.5543 (5.0); 8.5479 (1.0); 8.5161 20 (5.6); 8.1711 (1.1); 8.1684 (1.2); 8.1489 (1.8); 8.1278 (0.7); 7.7159 (0.5); 7.7125 (0.6); 7.7038 (0.7); 7.7007 (0.7); 7.6970 (1.4); 7.6936 (1.4); 7.6861 (0.7); 7.6829 (0.8); 7.6782 (1.0); 7.6747 (1.1); 7.6680 (0.8); 7.6044 (0.8); 7.6011 (1.0); 7.5970 (0.6); 7.5928 (0.5); 7.5851 (1.2); 7.5818 (1.4); 7.5659 (0.6); 7.5627 (0.7); 7.5508 (0.6); 7.5469 (0.6); 7.5390 (1.2); 7.5335 (1.1); 7.5286 (0.8); 7.5189 (1.1); 7.4725 (0.9); 7.4689 (0.9); 7.4544 (1.3); 7.4506 (1.3); 7.4024 (0.7); 7.3979 (0.7); 7.3900 (1.2); 7.3855 (1.4); 25 7.3785 (0.9); 7.3714 (1.0); 7.3671 (0.9); 7.3634 (0.6); 7.3538 (0.9); 7.3506 (1.0); 7.3325 (1.0); 7.2604 (33.0); 7.2183 (0.6); 7.1986 (0.6); 7.1245 (0.6); 7.1128 (1.3); 7.0940 (1.0); 5.3859 (1.0); 5.3690 (1.0); 5.3487 (0.7); 4.1309 (0.6); 4.1130 (0.6); 3.6857 (9.2); 3.6725 (16.0); 3.4584 (0.7); 3.4332 (0.8); 3.4109 (1.0); 2.1339 (1.0); 2.1148 (1.4); 2.1076 (1.3); 2.0884 (1.6); 2.0797 (0.6); 2.0606 (0.7); 2.0453 (2.6); 2.0168 (1.2); 1.9958 (1.5); 1.9815 (0.7); 1.9763 (0.9); 1.9605 (0.9); 1.5577 (2.8); 1.4779 (5.5); 1.4612 30 (5.5); 1.4161 (3.2); 1.3994 (3.2); 1.2772 (1.1); 1.2595 (2.2); 1.2416 (0.8); 0.8990 (0.6); 0.8820 (2.0); 0.8643 (0.8); 0.0080 (1.3); -0.0002 (46.7); -0.0084 (1.4) I.3-14: 1H-NMR(400.6 MHz, d6-DMSO): δ= 12.7565 (0.8); 9.0061 (0.7); 8.9894 (0.7); 8.6024 (4.0); 8.5961 (4.8); 8.5297 (5.8); 8.5233 (5.1); 8.0062 (1.6); 7.9869 (2.0); 7.8579 (0.5); 7.8531 (0.5); 7.8406 35 (6.0); 7.8358 (7.0); 7.7881 (3.3); 7.7834 (5.0); 7.7786 (2.3); 7.6604 (1.3); 7.6572 (1.4); 7.6419 (3.3); 7.5984 (1.4); 7.5921 (0.7); 7.5790 (1.4); 7.5723 (0.7); 7.5637 (0.6); 7.5571 (0.8); 5.0946 (0.8); 5.0777 (1.3); 5.0603 (0.8); 4.0556 (1.1); 4.0378 (3.4); 4.0200 (3.4); 4.0022 (1.1); 3.3183 (15.0); 2.6745 (0.8); BCS241005-Ausland STR 244 2.6699 (1.2); 2.6654 (0.9); 2.5400 (0.6); 2.5237 (2.7); 2.5191 (4.0); 2.5103 (67.0); 2.5057 (146.1); 2.5011 (203.9); 2.4965 (139.7); 2.4920 (61.1); 2.3328 (0.9); 2.3282 (1.2); 2.3235 (0.8); 2.0112 (0.5); 1.9886 (16.0); 1.3551 (1.4); 1.3441 (6.3); 1.3268 (6.3); 1.2343 (0.6); 1.1922 (4.7); 1.1807 (1.3); 1.1744 (9.7); 1.1566 (4.6); 0.8879 (0.5); 0.8711 (0.6); 0.1457 (0.6); 0.0118 (0.5); 0.0110 (0.7); 0.0102 (0.9); 5 0.0079 (5.8); 0.0063 (1.9); 0.0054 (2.1); 0.0046 (2.8); -0.0002 (191.3); -0.0043 (2.2); -0.0052 (1.5); - 0.0060 (1.2); -0.0068 (1.1); -0.0085 (5.0); -0.1494 (0.6) Gegenstand der vorliegenden Erfindung ist weiterhin die Verwendung einer oder mehrerer erfindungsgemäßer Verbindungen der allgemeinen Formel (I) und/oder deren Salze, wie oben definiert, 10 vorzugsweise in einer der als bevorzugt bzw. besonders bevorzugt gekennzeichneten Ausgestaltung, insbesondere einer oder mehrerer Verbindungen der Formeln (I.1-1) bis (I.3-18) und/oder deren Salze, jeweils wie oben definiert, als Herbizid und/oder Pflanzenwachstumsregulator, vorzugsweise in Kulturen von Nutz- und/oder Zierpflanzen. 15 Gegenstand der vorliegenden Erfindung ist ferner ein Verfahren zur Bekämpfung von Schadpflanzen und/oder zur Wachstumsregulierung von Pflanzen, dadurch gekennzeichnet, dass eine wirksame Menge - einer oder mehrerer erfindungsgemäßer Verbindungen der allgemeinen Formel (I) und/oder deren Salze, wie oben definiert, vorzugsweise in einer der als bevorzugt bzw. besonders 20 bevorzugt gekennzeichneten Ausgestaltung, insbesondere einer oder mehrerer Verbindungen der Formeln (I.1-1) bis (I.3-18) und/oder deren Salze, jeweils wie oben definiert, oder - eines erfindungsgemäßen Mittels, wie nachstehend definiert, auf die (Schad)Pflanzen, (Schad)Pflanzensamen, den Boden, in dem oder auf dem die (Schad)Pflanzen 25 wachsen, oder die Anbaufläche appliziert wird. Gegenstand der vorliegenden Erfindung ist auch ein Verfahren zur Bekämpfung von unerwünschten Pflanzen, vorzugsweise in Nutzpflanzenkulturen, dadurch gekennzeichnet, dass eine wirksame Menge 30 - einer oder mehrerer Verbindungen der allgemeinen Formel (I) und/oder deren Salze, wie oben definiert, vorzugsweise in einer der als bevorzugt bzw. besonders bevorzugt gekennzeichneten Ausgestaltung, insbesondere einer oder mehrerer Verbindungen der Formeln (I.1-1) bis (I.3-18) und/oder deren Salze, jeweils wie oben definiert, oder 35 - eines erfindungsgemäßen Mittels, wie nachstehend definiert, BCS241005-Ausland STR 245 auf unerwünschte Pflanzen (z.B. Schadpflanzen wie mono- oder dikotyle Unkräuter oder unerwünschte Kulturpflanzen), das Saatgut der unerwünschten Pflanzen (d.h. Pflanzensamen, z.B. Körner, Samen oder vegetative Vermehrungsorgane wie Knollen oder Sprossteile mit Knospen), den Boden, in dem oder auf dem die unerwünschte Pflanzen wachsen, (z.B. den Boden von Kulturland oder Nicht-Kulturland) oder 5 die Anbaufläche (d.h. Fläche, auf der die unerwünschten Pflanzen wachsen werden) appliziert wird. Gegenstand der vorliegenden Erfindung ist ferner auch ein Verfahren zur Bekämpfung zur Wachstumsregulierung von Pflanzen, vorzugsweise von Nutzpflanzen, dadurch gekennzeichnet, dass eine wirksame Menge 10 - einer oder mehrerer Verbindungen der allgmeinenen Formel (I) und/oder deren Salzen, wie oben definiert, vorzugsweise in einer der als bevorzugt bzw. besonders bevorzugt gekennzeichneten Ausgestaltung, insbesondere einer oder mehrerer Verbindungen der Formeln (I.1-1) bis (I.3-18) und/oder deren Salze, jeweils wie oben definiert, oder 15 - eines erfindungsgemäßen Mittels, wie nachstehend definiert, die Pflanze, das Saatgut der Pflanze (d.h. Pflanzensamen, z.B. Körner, Samen oder vegetative Vermehrungsorgane wie Knollen oder Sprossteile mit Knospen), den Boden, in dem oder auf dem die 20 Pflanzen wachsen, (z.B. den Boden von Kulturland oder Nicht-Kulturland) oder die Anbaufläche (d.h. Fläche, auf der die Pflanzen wachsen werden) appliziert wird. Dabei können die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) bzw. die erfindungsgemäßen Mittel z.B. im Vorsaat- (ggf. auch durch Einarbeitung in den Boden), Vorauflauf- 25 und/oder Nachauflaufverfahren ausgebracht werden. Im Einzelnen seien beispielhaft einige Vertreter der mono- und dikotylen Unkrautflora genannt, die durch die die erfindungsgemäßen Verbindungen kontrolliert werden können, ohne dass durch die Nennung eine Beschränkung auf bestimmte Arten erfolgen soll. 30 Vorzugsweise werden in einem erfindungsgemäßen Verfahren zur Bekämpfung von Schadpflanzen oder zur Wachstumsregulierung von Pflanzen eine oder mehrere Verbindungen der allgemeinen Formel (I) und/oder deren Salze zur Bekämpfung von Schadpflanzen oder zur Wachstumsregulierung in Kulturen von Nutzpflanzen oder Zierpflanzen eingesetzt, wobei die Nutzpflanzen oder Zierpflanzen in einer bevorzugten Ausgestaltung transgene Pflanzen sind. 35 Die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) und/oder deren Salze eignen sich zur Bekämpfung der folgenden Gattungen von monokotylen und dikotylen Schadpflanzen: BCS241005-Ausland STR 246 Monokotyle Schadpflanzen der Gattungen: Aegilops, Agropyron, Agrostis, Alopecurus, Apera, Avena, Brachiaria, Bromus, Cenchrus, Commelina, Cynodon, Cyperus, Dactyloctenium, Digitaria, Echinochloa, Eleocharis, Eleusine, Eragrostis, Eriochloa, Festuca, Fimbristylis, Heteranthera, Imperata, Ischaemum, Leptochloa, Lolium, Monochoria, Panicum, Paspalum, Phalaris, Phleum, Poa, Rottboellia, Sagittaria, 5 Scirpus, Setaria, Sorghum. Dikotyle Schadpflanzen der Gattungen: Abutilon, Amaranthus, Ambrosia, Anoda, Anthemis, Aphanes, Artemisia, Atriplex, Bellis, Bidens, Capsella, Carduus, Cassia, Centaurea, Chenopodium, Cirsium, Convolvulus, Datura, Desmodium, Emex, Erysimum, Euphorbia, Galeopsis, Galinsoga, Galium, Hibiscus, Ipomoea, Kochia, Lamium, Lepidium, Lindernia, Matricaria, Mentha, Mercurialis, Mullugo, 10 Myosotis, Papaver, Pharbitis, Plantago, Polygonum, Portulaca, Ranunculus, Raphanus, Rorippa, Rotala, Rumex, Salsola, Senecio, Sesbania, Sida, Sinapis, Solanum, Sonchus, Sphenoclea, Stellaria, Taraxacum, Thlaspi, Trifolium, Urtica, Veronica, Viola, Xanthium. Werden die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) vor dem Keimen der 15 Schadpflanzen (Ungräser und/oder Unkräuter) auf die Erdoberfläche appliziert (Vorauflaufverfahren), so wird entweder das Auflaufen der Ungras- bzw. Unkrautkeimlinge vollständig verhindert oder diese wachsen bis zum Keimblattstadium heran, stellen jedoch dann ihr Wachstum ein und sterben schließlich nach Ablauf von drei bis vier Wochen vollkommen ab. 20 Bei Applikation der erfindungsgemäßen Verbindungen der allgemeinen Formel (I) auf die grünen Pflanzenteile im Nachauflaufverfahren tritt nach der Behandlung Wachstumsstop ein und die Schadpflanzen bleiben in dem zum Applikationszeitpunkt vorhandenen Wachstumsstadium stehen oder sterben nach einer gewissen Zeit ganz ab, so dass auf diese Weise eine für die Kulturpflanzen schädliche Unkrautkonkurrenz sehr früh und nachhaltig beseitigt wird. 25 Obgleich die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) eine ausgezeichnete herbizide Aktivität gegenüber mono- und dikotylen Unkräutern aufweisen, werden Kulturpflanzen wirtschaftlich bedeutender Kulturen z.B. dikotyler Kulturen der Gattungen Arachis, Beta, Brassica, Cucumis, Cucurbita, Helianthus, Daucus, Glycine, Gossypium, Ipomoea, Lactuca, Linum, Lycopersicon, Miscanthus, Nicotiana, Phaseolus, Pisum, Solanum, Vicia, oder monokotyler Kulturen 30 der Gattungen Allium, Ananas, Asparagus, Avena, Hordeum, Oryza, Panicum, Saccharum, Secale, Sorghum, Triticale, Triticum, Zea, abhängig von der Struktur der jeweiligen erfindungsgemäßen Verbindung und deren Aufwandmenge nur unwesentlich oder gar nicht geschädigt. Die vorliegenden Verbindungen eignen sich aus diesen Gründen sehr gut zur selektiven Bekämpfung von unerwünschtem Pflanzenwuchs in Pflanzenkulturen wie landwirtschaftlichen Nutzpflanzungen oder Zierpflanzungen. 35 Darüberhinaus weisen die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) (abhängig von ihrer jeweiligen Struktur und der ausgebrachten Aufwandmenge) hervorragende BCS241005-Ausland STR 247 wachstumsregulatorische Eigenschaften bei Kulturpflanzen auf. Sie greifen regulierend in den pflanzeneigenen Stoffwechsel ein und können damit zur gezielten Beeinflussung von Pflanzeninhaltsstoffen und zur Ernteerleichterung wie z.B. durch Auslösen von Desikkation und Wuchsstauchung eingesetzt werden. Desweiteren eignen sie sich auch zur generellen Steuerung und 5 Hemmung von unerwünschtem vegetativem Wachstum, ohne dabei die Pflanzen abzutöten. Eine Hemmung des vegetativen Wachstums spielt bei vielen mono- und dikotylen Kulturen eine große Rolle, da beispielsweise die Lagerbildung hierdurch verringert oder völlig verhindert werden kann. Aufgrund ihrer herbiziden und pflanzenwachstumsregulatorischen Eigenschaften können die 10 erfindungsgemäßen Verbindungen der allgemeinen Formel (I) auch zur Bekämpfung von Schadpflanzen in Kulturen von gentechnisch oder durch konventionelle Mutagenese veränderten Pflanzen eingesetzt werden. Die transgenen Pflanzen zeichnen sich in der Regel durch besondere vorteilhafte Eigenschaften aus, beispielsweise durch Resistenzen gegenüber bestimmten Pestiziden, vor allem bestimmten Herbiziden, Resistenzen gegenüber Pflanzenkrankheiten oder Erregern von Pflanzenkrankheiten wie 15 bestimmten Insekten oder Mikroorganismen wie Pilzen, Bakterien oder Viren. Andere besondere Eigenschaften betreffen z.B. das Erntegut hinsichtlich Menge, Qualität, Lagerfähigkeit, Zusammensetzung und spezieller Inhaltsstoffe. So sind transgene Pflanzen mit erhöhtem Stärkegehalt oder veränderter Qualität der Stärke oder solche mit anderer Fettsäurezusammensetzung des Ernteguts bekannt. 20 Bevorzugt bezüglich transgener Kulturen ist die Anwendung der erfindungsgemäßen Verbindungen der allgemeinen Formel (I) und/oder deren Salze in wirtschaftlich bedeutenden transgenen Kulturen von Nutz und Zierpflanzen, z.B. von Getreide wie Weizen, Gerste, Roggen, Hafer, Hirse, Reis und Mais oder auch Kulturen von Zuckerrübe, Baumwolle, Soja, Raps, Kartoffel, Tomate, Erbse und anderen 25 Gemüsesorten. Vorzugsweise können die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) auch als Herbizide in Nutzpflanzenkulturen eingesetzt werden, welche gegenüber den phytotoxischen Wirkungen der Herbizide resistent sind bzw. gentechnisch resistent gemacht worden sind. 30 Aufgrund ihrer herbiziden und pflanzenwachstumsregulatorischen Eigenschaften können die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) auch zur Bekämpfung von Schadpflanzen in Kulturen von bekannten oder noch zu entwickelnden gentechnisch veränderten Pflanzen eingesetzt werden. Die transgenen Pflanzen zeichnen sich in der Regel durch besondere vorteilhafte Eigenschaften 35 aus, beispielsweise durch Resistenzen gegenüber bestimmten Pestiziden, vor allem bestimmten Herbiziden, Resistenzen gegenüber Pflanzenkrankheiten oder Erregern von Pflanzenkrankheiten wie bestimmten Insekten oder Mikroorganismen wie Pilzen, Bakterien oder Viren. Andere besondere BCS241005-Ausland STR 248 Eigenschaften betreffen z.B. das Erntegut hinsichtlich Menge, Qualität, Lagerfähigkeit, Zusammensetzung und spezieller Inhaltsstoffe. So sind transgene Pflanzen mit erhöhtem Stärkegehalt oder veränderter Qualität der Stärke oder solche mit anderer Fettsäurezusammensetzung des Ernteguts bekannt. Weitere besondere Eigenschaften können in einer Toleranz oder Resistenz gegen abiotische 5 Stressoren z.B. Hitze, Kälte, Trockenheit, Salz und ultraviolette Strahlung liegen. Bevorzugt ist die Anwendung der erfindungsgemäßen Verbindungen der allgemeinen Formel (I) oder deren Salze in wirtschaftlich bedeutenden transgenen Kulturen von Nutz-und Zierpflanzen, z.B. von Getreide wie Weizen, Gerste, Roggen, Hafer, Triticale, Hirse, Reis, Maniok und Mais oder auch 10 Kulturen von Zuckerrübe, Baumwolle, Soja, Raps, Kartoffel, Tomate, Erbse und anderen Gemüsesorten. Vorzugsweise können die Verbindungen der allgemeinen Formel (I) als Herbizide in Nutzpflanzenkulturen eingesetzt werden, welche gegenüber den phytotoxischen Wirkungen der Herbizide resistent sind bzw. gentechnisch resistent gemacht worden sind. 15 Herkömmliche Wege zur Herstellung neuer Pflanzen, die im Vergleich zu bisher vorkommenden Pflanzen modifizierte Eigenschaften aufweisen, bestehen beispielsweise in klassischen Züchtungsverfahren und der Erzeugung von Mutanten. Alternativ können neue Pflanzen mit veränderten Eigenschaften mit Hilfe gentechnischer Verfahren erzeugt werden. 20 Zahlreiche molekularbiologische Techniken, mit denen neue transgene Pflanzen mit veränderten Eigenschaften hergestellt werden können, sind dem Fachmann bekannt. Für derartige gentechnische Manipulationen können Nucleinsäuremoleküle in Plasmide eingebracht werden, die eine Mutagenese oder eine Sequenzveränderung durch Rekombination von DNA-Sequenzen erlauben. Mit Hilfe von 25 Standardverfahren können z.B. Basenaustausche vorgenommen, Teilsequenzen entfernt oder natürliche oder synthetische Sequenzen hinzugefügt werden. Für die Verbindung der DNA-Fragmente untereinander können an die Fragmente Adaptoren oder Linker angesetzt werden. Die Herstellung von Pflanzenzellen mit einer verringerten Aktivität eines Genprodukts kann 30 beispielsweise erzielt werden durch die Expression mindestens einer entsprechenden antisense-RNA, einer sense-RNA zur Erzielung eines Cosuppressionseffektes oder die Expression mindestens eines entsprechend konstruierten Ribozyms, das spezifisch Transkripte des obengenannten Genprodukts spaltet. 35 Hierzu können zum einen DNA-Moleküle verwendet werden, die die gesamte codierende Sequenz eines Genprodukts einschließlich eventuell vorhandener flankierender Sequenzen umfassen, als auch DNA- Moleküle, die nur Teile der codierenden Sequenz umfassen, wobei diese Teile lang genug sein müssen, BCS241005-Ausland STR 249 um in den Zellen einen antisense-Effekt zu bewirken. Möglich ist auch die Verwendung von DNA- Sequenzen, die einen hohen Grad an Homologie zu den codiereden Sequenzen eines Genprodukts aufweisen, aber nicht vollkommen identisch sind. 5 Bei der Expression von Nucleinsäuremolekülen in Pflanzen kann das synthetisierte Protein in jedem beliebigen Kompartiment der pflanzlichen Zelle lokalisiert sein. Um aber die Lokalisation in einem bestimmten Kompartiment zu erreichen, kann z.B. die codierende Region mit DNA-Sequenzen verknüpft werden, die die Lokalisierung in einem bestimmten Kompartiment gewährleisten. Derartige Sequenzen sind dem Fachmann bekannt (siehe beispielsweise Braun et al., EMBO J.11 (1992), 3219- 10 3227). Die Expression der Nukleinsäuremoleküle kann auch in den Organellen der Pflanzenzellen stattfinden. Die transgenen Pflanzenzellen können nach bekannten Techniken zu ganzen Pflanzen regeneriert werden. Bei den transgenen Pflanzen kann es sich prinzipiell um Pflanzen jeder beliebigen 15 Pflanzenspezies handeln, d.h. sowohl monokotyle als auch dikotyle Pflanzen. So sind transgene Pflanzen erhältlich, die veränderte Eigenschaften durch Überexpression, Suppression oder Inhibierung homologer (= natürlicher) Gene oder Gensequenzen oder Expression heterologer (= fremder) Gene oder Gensequenzen aufweisen. 20 Vorzugsweise können die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) in transgenen Kulturen eingesetzt werden, welche gegen Wuchsstoffe, wie z.B. Dicamba oder gegen Herbizide, die essentielle Pflanzenenzyme, z.B. Acetolactatsynthasen (ALS), EPSP Synthasen, Glutaminsynthasen (GS) oder Hydoxyphenylpyruvat Dioxygenasen (HPPD) hemmen, respektive gegen Herbizide aus der 25 Gruppe der Sulfonylharnstoffe, der Glyphosate, Glufosinate oder Benzoylisoxazole und analogen Wirkstoffe, resistent sind. Bei der Anwendung der erfindungsgemäßen Verbindungen der allgemeinen Formel (I) in transgenen Kulturen treten neben den in anderen Kulturen zu beobachtenden Wirkungen gegenüber Schadpflanzen 30 oftmals Wirkungen auf, die für die Applikation in der jeweiligen transgenen Kultur spezifisch sind, beispielsweise ein verändertes oder speziell erweitertes Unkrautspektrum, das bekämpft werden kann, veränderte Aufwandmengen, die für die Applikation eingesetzt werden können, vorzugsweise gute Kombinierbarkeit mit den Herbiziden, gegenüber denen die transgene Kultur resistent ist, sowie Beeinflussung von Wuchs und Ertrag der transgenen Kulturpflanzen. 35 BCS241005-Ausland STR 250 Gegenstand der Erfindung ist deshalb auch die Verwendung der erfindungsgemäßen Verbindungen der allgemeinen Formel (I) und/oder deren Salze als Herbizide zur Bekämpfung von Schadpflanzen in Kulturen von Nutz- oder Zierpflanzen, gegebenenfalls in transgenen Kulturpflanzen. 5 Bevorzugt ist die Verwendung in Getreide, dabei vorzugsweise Mais, Weizen, Gerste, Roggen, Hafer, Hirse, oder Reis, im Vor- oder Nachauflauf. Bevorzugt ist auch die Verwendung in Soja im Vor- oder Nachauflauf. 10 Die erfindungsgemäße Verwendung zur Bekämpfung von Schadpflanzen oder zur Wachstumsregulierung von Pflanzen schließt auch den Fall ein, bei dem eine Verbindung der allgemeinen Formel (I) oder deren Salz erst nach der Ausbringung auf der Pflanze, in der Pflanze oder im Boden aus einer Vorläufersubstanz ("Prodrug") gebildet wird. 15 Gegenstand der Erfindung ist auch die Verwendung einer oder mehrerer Verbindungen der allgemeinen Formel (I) oder deren Salzen bzw. eines erfindungsgemäßen Mittels (wie nachstehend definiert) (in einem Verfahren) zur Bekämpfung von Schadpflanzen oder zur Wachstumsregulierung von Pflanzen, dadurch gekennzeichnet, dass man eine wirksame Menge einer oder mehreren Verbindungen der allgemeinen Formel (I) oder deren Salzen auf die Pflanzen (Schadpflanzen, ggf. zusammen mit den 20 Nutzpflanzen) Pflanzensamen, den Boden, in dem oder auf dem die Pflanzen wachsen, oder die Anbaufläche appliziert. Gegenstand der Erfindung ist auch ein herbizides und/oder pflanzenwachstumsregulierendes Mittel, dadurch gekennzeichnet, dass das Mittel 25 (a) eine oder mehrere Verbindungen der allgemeinen Formel (I) und/oder deren Salze enthält wie oben definiert, vorzugsweise in einer der als bevorzugt bzw. besonders bevorzugt gekennzeichneten Ausgestaltung, insbesondere eine oder mehrere Verbindungen der Formeln (I.1-1) bis (I.3-18) und/oder deren Salze, jeweils wie oben definiert, 30 und (b) ein oder mehrere weitere Stoffe ausgewählt aus den Gruppen (i) und/oder (ii): (i) ein oder mehrere weitere agrochemisch wirksame Stoffe, vorzugsweise ausgewählt aus der 35 Gruppe bestehend aus Insektiziden, Akariziden, Nematiziden, weiteren Herbiziden (d.h. solche, die nicht der oben definierten allgemeinen Formel (I) entsprechen), Fungiziden, Safenern, Düngemitteln und/oder weiteren Wachstumsregulatoren, BCS241005-Ausland STR 251 (ii) ein oder mehrere im Pflanzenschutz übliche Formulierungshilfsmittel. Die weiteren agrochemischen wirksamen Stoffe des Bestandteils (i) eines erfindungsgemäßen Mittels 5 sind dabei vorzugsweise ausgewählt aus der Gruppe der Stoffe, die in "The Pesticide Manual", 16th edition, The British Crop Protection Council und the Royal Soc. of Chemistry, 2012 genannt sind. Ein erfindungsgemäßes herbizides oder pflanzenwachstumsregulierendes Mittel, umfasst vorzugsweise ein, zwei, drei oder mehr im Pflanzenschutz übliche Formulierungshilfsmittel (ii) ausgewählt aus der 10 Gruppe bestehend aus Tensiden, Emulgatoren, Dispergiermitteln, Filmbildnern, Verdickungsmitteln, anorganischen Salzen, Stäubemitteln, bei 25 °C und 1013 mbar festen Trägerstoffen, vorzugsweise adsorptionsfähigen, granulierten Inertmaterialien, Netzmitteln, Antioxidationsmitteln, Stabilisatoren, Puffersubstanzen, Antischaummitteln, Wasser, organischen Lösungsmitteln, vorzugsweise bei 25 °C und 1013 mbar mit Wasser in jedem beliebigen Verhältnis mischbare organische Lösungsmittel. 15 Die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) können in Form von Spritzpulvern, emulgierbaren Konzentraten, versprühbaren Lösungen, Stäubemitteln oder Granulaten in den üblichen Zubereitungen angewendet werden. Gegenstand der Erfindung sind deshalb auch herbizide und pflanzenwachstumsregulierende Mittel, die Verbindungen der allgemeinen Formel (I) und/oder deren 20 Salze enthalten. Die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) und/oder deren Salze können auf verschiedene Art formuliert werden, je nachdem welche biologischen und/oder chemisch-physikalischen Parameter vorgegeben sind. Als Formulierungsmöglichkeiten kommen beispielsweise in Frage: 25 Spritzpulver (WP), wasserlösliche Pulver (SP), wasserlösliche Konzentrate, emulgierbare Konzentrate (EC), Emulsionen (EW), wie Öl-in-Wasser- und Wasser-in-Öl-Emulsionen, versprühbare Lösungen, Suspensionskonzentrate (SC), Dispersionen auf Öl- oder Wasserbasis, ölmischbare Lösungen, Kapselsuspensionen (CS), Stäubemittel (DP), Beizmittel, Granulate für die Streu- und Bodenapplikation, Granulate (GR) in Form von Mikro-, Sprüh-, Aufzugs- und Adsorptionsgranulaten, 30 wasserdispergierbare Granulate (WG), wasserlösliche Granulate (SG), ULV-Formulierungen, Mikrokapseln und Wachse. Diese einzelnen Formulierungstypen und die Formulierungshilfsmittel wie Inertmaterialien, Tenside, Lösungsmittel und weitere Zusatzstoffe sind dem Fachmann bekannt, und werden beispielsweise beschrieben in: Watkins, "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Darland 35 Books, Caldwell N.J., H.v. Olphen, "Introduction to Clay Colloid Chemistry"; 2nd Ed., J. Wiley & Sons, N.Y.; C. Marsden, "Solvents Guide"; 2nd Ed., Interscience, N.Y.1963; McCutcheon's "Detergents and Emulsifiers Annual", MC Publ. Corp., Ridgewood N.J.; Sisley and Wood, "Encyclopedia of Surface BCS241005-Ausland STR 252 Active Agents", Chem. Publ. Co. Inc., N.Y.1964; Schönfeldt, "Grenzflächenaktive Äthylenoxidaddukte", Wiss. Verlagsgesellschaft, Stuttgart 1976; Winnacker-Küchler, "Chemische Technologie", Band 7, C. Hanser Verlag München, 4. Aufl.1986. 5 Spritzpulver sind in Wasser gleichmäßig dispergierbare Präparate, die neben dem Wirkstoff außer einem Verdünnungs- oder Inertstoff noch Tenside ionischer und/oder nichtionischer Art (Netzmittel, Dispergiermittel), z.B. polyoxyethylierte Alkylphenole, polyoxethylierte Fettalkohole, polyoxethylierte Fettamine, Fettalkoholpolyglykolethersulfate, Alkansulfonate, Alkylbenzolsulfonate, ligninsulfonsaures Natrium, 2,2'-dinaphthylmethan-6,6'-disulfonsaures Natrium, dibutylnaphthalin-sulfonsaures Natrium 10 oder auch oleoylmethyltaurinsaures Natrium enthalten. Zur Herstellung der Spritzpulver werden die herbiziden Wirkstoffe beispielsweise in üblichen Apparaturen wie Hammermühlen, Gebläsemühlen und Luftstrahlmühlen feingemahlen und gleichzeitig oder anschließend mit den Formulierungshilfsmitteln vermischt. 15 Emulgierbare Konzentrate werden durch Auflösen des Wirkstoffes in einem organischen Lösungsmittel z.B. Butanol, Cyclohexanon, Dimethylformamid, Xylol oder auch höhersiedenden Aromaten oder Kohlenwasserstoffen oder Mischungen der organischen Lösungsmittel unter Zusatz von einem oder mehreren Tensiden ionischer und/oder nichtionischer Art (Emulgatoren) hergestellt. Als Emulgatoren können beispielsweise verwendet werden: Alkylarylsulfonsaure Calcium-Salze wie 20 Ca-dodecylbenzolsulfonat oder nichtionische Emulgatoren wie Fettsäurepolyglykolester, Alkylarylpolyglykolether, Fettalkoholpolyglykolether, Propylenoxid-Ethylenoxid- Kondensationsprodukte, Alkylpolyether, Sorbitanester wie z.B. Sorbitanfettsäureester oder Polyoxethylensorbitanester wie z.B. Polyoxyethylensorbitanfettsäureester. 25 Stäubemittel erhält man durch Vermahlen des Wirkstoffes mit fein verteilten festen Stoffen, z.B. Talkum, natürlichen Tonen, wie Kaolin, Bentonit und Pyrophyllit, oder Diatomeenerde. Suspensionskonzentrate können auf Wasser- oder Ölbasis sein. Sie können beispielsweise durch Nass-Vermahlung mittels handelsüblicher Perlmühlen und gegebenenfalls Zusatz von Tensiden, wie sie 30 z.B. oben bei den anderen Formulierungstypen bereits aufgeführt sind, hergestellt werden. Emulsionen, z.B. Öl-in-Wasser-Emulsionen (EW), lassen sich beispielsweise mittels Rührern, Kolloidmühlen und/oder statischen Mischern unter Verwendung von wässrigen organischen Lösungsmitteln und gegebenenfalls Tensiden, wie sie z.B. oben bei den anderen Formulierungstypen bereits aufgeführt sind, herstellen. 35 Granulate können entweder durch Verdüsen des Wirkstoffes auf adsorptionsfähiges, granuliertes Inertmaterial hergestellt werden oder durch Aufbringen von Wirkstoffkonzentraten mittels Klebemitteln, BCS241005-Ausland STR 253 z.B. Polyvinylalkohol, polyacrylsaurem Natrium oder auch Mineralölen, auf die Oberfläche von Trägerstoffen wie Sand, Kaolinite oder von granuliertem Inertmaterial. Auch können geeignete Wirkstoffe in der für die Herstellung von Düngemittelgranulaten üblichen Weise - gewünschtenfalls in Mischung mit Düngemitteln - granuliert werden. 5 Wasserdispergierbare Granulate werden in der Regel nach den üblichen Verfahren wie Sprühtrocknung, Wirbelbett-Granulierung, Teller-Granulierung, Mischung mit Hochgeschwindigkeitsmischern und Extrusion ohne festes Inertmaterial hergestellt. 10 Zur Herstellung von Teller-, Fließbett-, Extruder- und Sprühgranulaten siehe z.B. Verfahren in "Spray- Drying Handbook" 3rd ed.1979, G. Goodwin Ltd., London; J.E. Browning, "Agglomeration", Chemical and Engineering 1967, Seiten 147 ff; "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, New York 1973, S.8-57. 15 Für weitere Einzelheiten zur Formulierung von Pflanzenschutzmitteln siehe z.B. G.C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc., New York, 1961, Seiten 81-96 und J.D. Freyer, S.A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, Seiten 101-103. 20 Die agrochemischen Zubereitungen, vorzugsweise herbizide oder pflanzenwachstumsregulierende Mittel der vorliegenden Erfindung enthalten vorzugsweise eine Gesamtmenge von 0,1 bis 99 Gew.-%, bevorzugt 0,5 bis 95 Gew.-%, weiter bevorzugt 1 bis 90 Gew.-%, insbesondere bevorzugt 2 bis 80 Gew.-%, an Wirkstoffen der allgemeinen Formel (I) und deren Salzen. 25 In Spritzpulvern beträgt die Wirkstoffkonzentration z.B. etwa 10 bis 90 Gew.-%, der Rest zu 100 Gew.-% besteht aus üblichen Formulierungsbestandteilen. Bei emulgierbaren Konzentraten kann die Wirkstoffkonzentration etwa 1 bis 90, vorzugsweise 5 bis 80 Gew.-% betragen. Staubförmige Formulierungen enthalten 1 bis 30 Gew.-% Wirkstoff, vorzugsweise meistens 5 bis 20 Gew.-% an Wirkstoff, versprühbare Lösungen enthalten etwa 0,05 bis 80, vorzugsweise 2 bis 50 Gew.-% Wirkstoff. 30 Bei wasserdispergierbaren Granulaten hängt der Wirkstoffgehalt zum Teil davon ab, ob die wirksame Verbindung flüssig oder fest vorliegt und welche Granulierhilfsmittel, Füllstoffe usw. verwendet werden. Bei den in Wasser dispergierbaren Granulaten liegt der Gehalt an Wirkstoff beispielsweise zwischen 1 und 95 Gew.-%, vorzugsweise zwischen 10 und 80 Gew.-%. 35 Daneben enthalten die genannten Wirkstoffformulierungen gegebenenfalls die jeweils üblichen Haft-, Netz-, Dispergier-, Emulgier-, Penetrations-, Konservierungs-, Frostschutz- und Lösungsmittel, Füll-, Träger- und Farbstoffe, Entschäumer, Verdunstungshemmer und den pH-Wert und die Viskosität BCS241005-Ausland STR 254 beeinflussende Mittel. Beispiele für Formulierungshilfsmittel sind unter anderem in "Chemistry and Technology of Agrochemical Formulations", ed. D. A. Knowles, Kluwer Academic Publishers (1998) beschrieben. 5 Die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) oder deren Salze können als solche oder in Form ihrer Zubereitungen (Formulierungen) mit anderen pestizid wirksamen Stoffen, wie z.B. Insektiziden, Akariziden, Nematiziden, Herbiziden, Fungiziden, Safenern, Düngemitteln und/oder Wachstumsregulatoren kombiniert eingesetzt werden, z.B. als Fertigformulierung oder als Tankmischungen. Die Kombinationsformulierungen können dabei auf Basis der obengenannten 10 Formulierungen hergestellt werden, wobei die physikalischen Eigenschaften und Stabilitäten der zu kombinierenden Wirkstoffe zu berücksichtigen sind. Als Kombinationspartner für die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) in Mischungsformulierungen oder im Tank-Mix sind beispielsweise bekannte Wirkstoffe, die auf einer 15 Inhibition von beispielsweise Acetolactat-Synthase, Acetyl-CoA-Carboxylase, Cellulose-Synthase, Enolpyruvylshikimat-3-phosphat-Synthase, Glutamin-Synthetase, p-Hydroxyphenylpyruvat- Dioxygenase, Phytoendesaturase, Photosystem I, Photosystem II, Protoporphyrinogen-Oxidase beruhen, einsetzbar, wie sie z.B. in Weed Research 26 (1986) 441-445 oder "The Pesticide Manual", 16th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2012 und der dort zitierten 20 Literatur beschrieben sind. Von besonderem Interesse ist die selektive Bekämpfung von Schadpflanzen in Kulturen von Nutz- und Zierpflanzen. Obgleich die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) bereits in vielen Kulturen sehr gute bis ausreichende Selektivität aufweisen, können prinzipiell in einigen Kulturen 25 und vor allem auch im Falle von Mischungen mit anderen Herbiziden, die weniger selektiv sind, Phytotoxizitäten an den Kulturpflanzen auftreten. Diesbezüglich sind Kombinationen erfindungsgemäßer Verbindungen der allgemeinen Formel (I) von besonderem Interesse, welche die Verbindungen (I) bzw. deren Kombinationen mit anderen Herbiziden oder Pestiziden und Safenern enthalten. Die Safener, welche in einem antidotisch wirksamen Gehalt eingesetzt werden, reduzieren die 30 phytotoxischen Nebenwirkungen der eingesetzten Herbizide/Pestizide, z.B. in wirtschaftlich bedeutenden Kulturen wie Getreide (Weizen, Gerste, Roggen, Mais, Reis, Hirse), Zuckerrübe, Zuckerrohr, Raps, Baumwolle und Soja, vorzugsweise Getreide. Die Gewichtsverhältnisse von Herbizid(mischung) zu Safener hängt im Allgemeinen von der 35 Aufwandmenge an Herbizid und der Wirksamkeit des jeweiligen Safeners ab und kann innerhalb weiter Grenzen variieren, beispielsweise im Bereich von 200:1 bis 1:200, vorzugsweise 100:1 bis 1:100, insbesondere 20:1 bis 1:20. Die Safener können analog den Verbindungen der allgemeinen Formel (I) BCS241005-Ausland STR 255 oder deren Mischungen mit weiteren Herbiziden/Pestiziden formuliert werden und als Fertigformulierung oder Tankmischung mit den Herbiziden bereitgestellt und angewendet werden. Zur Anwendung werden die in handelsüblicher Form vorliegenden Herbizid- oder Herbizid-Safener- 5 Formulierungen gegebenenfalls in üblicher Weise verdünnt z.B. bei Spritzpulvern, emulgierbaren Konzentraten, Dispersionen und wasserdispergierbaren Granulaten mittels Wasser. Staubförmige Zubereitungen, Boden- bzw. Streugranulate sowie versprühbare Lösungen werden vor der Anwendung üblicherweise nicht mehr mit weiteren inerten Stoffen verdünnt. 10 Äußere Bedingungen wie Temperatur, Feuchtigkeit etc. beeinflussen zu einem gewissen Teil die Aufwandmenge der erfindungsgemäßen Verbindungen der allgemeinen Formel (I) und/oder deren Salze. Die Aufwandmenge kann dabei innerhalb weiter Grenzen variieren. Für die Anwendung als Herbizid zur Bekämpfung von Schadpflanzen liegt die Gesamtmenge an erfindungsgemäßen Verbindungen der allgemeinen Formel (I) und deren Salze vorzugsweise im Bereich von 0,001 bis 10,0 15 kg/ha, bevorzugt im Bereich von 0,005 bis 5 kg/ha, weiter bevorzugt im Bereich von 0,01 bis 1,5 kg/ha, insbesondere bevorzugt im Bereich von 0,05 bis 1 kg/ha. Dies gilt sowohl für die Anwendung im Vorauflauf oder im Nachauflauf. Bei der Anwendung von erfindungsgemäßen Verbindungen der allgemeinen Formel (I) und/oder deren 20 Salzen als Pflanzenwachstumsregulator, beispielsweise als Halmverkürzer bei Kulturpflanzen, wie sie oben genannt worden sind, vorzugsweise bei Getreidepflanzen wie Weizen, Gerste, Roggen, Triticale, Hirse, Reis oder Mais, liegt die Gesamt-Aufwandmenge vorzugsweise im Bereich von 0,001 bis 2 kg/ha, vorzugsweise im Bereich von 0,005 bis 1 kg/ha, insbesondere im Bereich von 10 bis 500 g/ha, ganz besonders bevorzugt im Bereich von 20 bis 250 g/ha. Dies gilt sowohl für die Anwendung im 25 Vorauflauf oder im Nachauflauf. Die Applikation als Halmverkürzer kann in verschiedenen Stadien des Wachstums der Pflanzen erfolgen. Bevorzugt ist beispielsweise die Anwendung nach der Bestockung am Beginn des Längenwachstums. 30 Alternativ kommt bei der Anwendung als Pflanzenwachstumsregulator auch die Behandlung des Saatguts in Frage, welche die unterschiedlichen Saatgutbeiz- und Beschichtungstechniken einschließt. Die Aufwandmenge hängt dabei von den einzelnen Techniken ab und kann in Vorversuchen ermittelt werden. 35 Als Kombinationspartner für die Verbindungen der allgemeinen Formel (I) in Mischungsformulierungen oder im Tank-Mix sind beispielsweise bekannte Wirkstoffe, die auf einer Inhibition von beispielsweise BCS241005-Ausland STR 256 Acetolactat-Synthase, Acetyl-CoA-Carboxylase, Cellulose-Synthase, Enolpyruvylshikimat-3-phosphat- Synthase, Glutamin-Synthetase, p-Hydroxyphenylpyruvat-Dioxygenase, Phytoendesaturase, Photosystem I, Photosystem II, Protoporphyrinogen-Oxidase beruhen oder als Pflanzenwuchsregulatoren wirken, einsetzbar, wie sie z.B. aus Weed Research 26 (1986) 441-445 oder 5 "The Pesticide Manual", 19th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2021 und dort zitierter Literatur beschrieben sind. Als bekannte Herbizide oder Pflanzenwachstumsregulatoren, die mit Verbindungen der allgemeinen Formel (I) kombiniert werden können, sind z.B. folgende Wirkstoffe zu nennen (die Verbindungen sind 10 entweder mit dem "common name" nach der International Organization for Standardization (ISO) oder mit dem chemischen Namen oder mit der Codenummer bezeichnet) und umfassen stets sämtliche Anwendungsformen wie Säuren, Salze, Ester und Isomere wie Stereoisomere und optische Isomere. Dabei sind beispielhaft eine und zum Teil auch mehrere Anwendungsformen genannt: Acetochlor, Acifluorfen, Acifluorfen-methyl, Acifluorfen-Natrium, Aclonifen, Alachlor, Allidochlor,15 Alloxydim, Alloxydim-Natrium, Ametryn, Amicarbazon, Amidochlor, Amidosulfuron, 4-Amino-3- chlor-6-(4-chlor-2-fluor-3-methylphenyl)-5-fluorpyridin-2-carbonsäure, Aminocyclopyrachlor, Aminocyclopyrachlor-Kalium, Aminocyclopyrachlor-methyl, Aminopyralid, Aminopyralid- dimethylammonium, Aminopyralid-tripromine, Amitrol, Ammoniumsulfamate, Anilofos, Asulam, Asulam-Kalium, Asulam-Natrium, Atrazin, Azafenidin, Azimsulfuron, Beflubutamid, (S)-(-)- 20 Beflubutamid, Beflubutamid-M, Benazolin, Benazolin-ethyl, Benazolin-dimethylammonium, Benazolin-Kalium, Benfluralin, Benfuresate, Bensulfuron, Bensulfuron-methyl, Bensulid, Bentazon, Bentazon-Natrium, Benzobicyclon, Benzofenap, Bicyclopyrone, Bifenox, Bilanafos, Bilanafos-Natrium, Bipyrazone, Bispyribac, Bispyribac-Natium, Bixlozon, Bromacil, Bromacil-lithium, Bromacil-Natrium, Bromobutid, Bromofenoxim, Bromoxynil, Bromoxynilbutyrat, Bromoxynil-Kalium, Bromoxynil- 25 heptanoat und Bromoxynil-octanoat, Busoxinon, Butachlor, Butafenacil, Butamifos, Butenachlor, Butralin, Butroxydim, Butylat, Cafenstrol, Cambendichlor, Carbetamide, Carfentrazon, Carfentrazon- Ethyl, Chloramben, Chloramben-ammonium, Chloramben-diolamin, Chlroamben-methyl, Chloramben- methylammonium, Chloramben-Natrium, Chlorbromuron, Chlorfenac, Chlorfenac-ammonium, Chlorfenac-Natrium, Chlorfenprop, Chlorfenprop-methyl, Chlorflurenol, Chlorflurenol-methyl, 30 Chloridazon, Chlorimuron, Chlorimuron-ethyl, Chlorophthalim, Chlorotoluron, Chlorsulfuron, Chlorthal, Chlorthal-dimethyl, Chlorthal-monomethyl, Cinflubrolin, Cinidon, Cinidon-ethyl, Cinmethylin, exo-(+)-Cinmethylin, d.h. (1R,2S,4S)-4-isopropyl-1-methyl-2-[(2-methylbenzyl)oxy]-7- oxabicyclo[2.2.1]heptan, exo-(-)-Cinmethylin, d.h. (1R,2S,4S)-4-isopropyl-1-methyl-2-[(2- methylbenzyl)oxy]-7-oxabicyclo[2.2.1]heptan, Cinosulfuron, Clacyfos, Clethodim, Clodinafop, 35 Clodinafop-ethyl, Clodinafop-propargyl, Clomazon, Clomeprop, Clopyralid, Clopyralid-methyl, Clopyralid-olamin, Clopyralid-Kalium, Clopyralid-tripomin, Cloransulam, Cloransulam-methyl, Cumyluron, Cyanamide, Cyanazine, Cycloat, Cyclopyranil, Cyclopyrimorat, Cyclosulfamuron, BCS241005-Ausland STR 257 Cycloxydim, Cyhalofop, Cyhalofop-butyl, Cyprazin, 2,4-D (sowie die Ammonium, Butotyl, Butyl, Cholin, Diethylammonium, Dimethylammonium, Diolamin, Doboxyl, Dodecylammonium, Etexyl, Ethyl, 2-Ethylhexyl, Heptylammonium, Isobutyl, Isooctyl, Isopropyl, Isopropylammonium, Lithium, Meptyl, Methyl, Kalium, Tetradecylammonium, Triethylammonium, Triisopropanolammonium, 5 Tripromin and Trolamin Salze davon), 2,4-DB, 2,4-DB-butyl, 2,4-DB-Dimethylammonium, 2,4-DB- isooctyl, 2,4-DB-Kalium und 2,4-DB-Natrium, Daimuron (Dymron), Dalapon, Dalapon-Calcium, Dalapon-Magnesium, Dalapon-Natium, Dazomet, Dazomet-Natrium, n-Decanol, 7-Deoxy-D- sedoheptulose, Desmedipham, Detosyl-pyrazolat (DTP), Dicamba und seine Salze (z.B. Dicamba- biproamin, Dicamba-N,N-Bis(3-aminopropyl)methylamin, Dicamba-butotyl, Dicamba-cholin, Dicamba-10 Diglycolamin, Dicamba-Dimethylammonium, Dicamba-Diethanolaminemmonium, Dicamba- Diethylammonium, Dicamba-isopropylammonium, Dicamba-methyl, Dicamba-monoethanolamin, Dicamba-olamin, Dicamba-Kalium, Dicamba-Natrium, Dicamba-Triethanolamin), Dichlobenil, 2-(2,4- Dichlorbenzyl)-4,4-dimethyl-1,2-oxazolidin-3-on, 2-(2,5-Dichlorbenzyl)-4,4-dimethyl-1,2-oxazolidin-3- on, Dichlorprop, Dichlorprop-butotyl, Dichlorprop-Dimethylammonium, Dichhlorprop-etexyl, 15 Dichlorprop-ethylammonium, Dichlorprop-isoctyl, Dichlorprop-methyl, Dichlorprop-Kalium, Dichlorprop-Natrium, Dichlorprop-P, Dichlorprop-P-Dimethylammonium, Dichlorprop-P-etexyl, Dichlorprop-P-Kalium, Dichlorprop-Natrium, Diclofop, Diclofop-methyl, Diclofop-P, Diclofop-P- methyl, Diclosulam, Difenzoquat, Difenzoquat-metilsulfate, Diflufenican, Diflufenzopyr, Diflufenzopyr-Natrium, Dimefuron, Dimepiperate, Dimesulfazet, Dimethachlor, Dimethametryn, 20 Dimethenamid, Dimethenamid-P, Dimetrasulfuron, Dinitramine, Dinoterb, Dinoterb-Acetate, Diphenamid, Diquat, Diquat-Dibromid, Diquat-Dichlorid, Dithiopyr, Diuron, DNOC, DNOC- Ammonium, DNOC-Kalium, DNOC-Natrium, Endothal, Endothal-Diammonium, Endothal-Dikalium, Endothal-Dinatrium, Epyrifenacil, EPTC, Esprocarb, Ethalfluralin, Ethametsulfuron, Ethametsulfuron- Methyl, Ethiozin, Ethofumesate, Ethoxyfen, Ethoxyfen-Ethyl, Ethoxysulfuron, Etobenzanid, F-5231,25 d.h. N-[2-Chlor-4-fluor-5-[4-(3-fluorpropyl)-4,5-dihydro-5-oxo-1H-tetrazol-1-yl]-phenyl]- ethansulfonamid, F-7967, i.e.3-[7-Chlor-5-fluor-2-(trifluormethyl)-1H-benzimidazol-4-yl]-1-methyl-6- (trifluormethyl)pyrimidin-2,4(1H,3H)-dion, Fenoxaprop, Fenoxaprop-P, Fenoxaprop-Ethyl, Fenoxaprop-P-Ethyl, Fenoxasulfone, Fenpyrazone, Fenquinotrione, Fentrazamid, Flamprop, Flamprop- Isoproyl, Flamprop-Methyl, Flamprop-M-Isopropyl, Flamprop-M-Methyl, Flazasulfuron, Florasulam, 30 Florpyrauxifen, Florpyrauxifen-benzyl, Fluazifop, Fluazifop-Butyl, Fluazifop-Methyl, Fluazifop-P, Fluazifop-P-Butyl, Flucarbazone, Flucarbazone-Natrium, Flucetosulfuron, Fluchloralin, Flufenacet, Flufenpyr, Flufenpyr-Ethyl, Flumetsulam, Flumiclorac, Flumiclorac-Pentyl, Flumioxazin, Fluometuron, Flurenol, Flurenol-Butyl, -Dimethylammonium und -Methyl, Fluoroglycofen, Fluoroglycofen-Ethyl, Flupropanat, Flupropanat-Natrium, Flupyrsulfuron, Flupyrsulfuron-Methyl, Flupyrsulfuron-Methyl- 35 Natrium, Fluridon, Flurochloridon, Fluroxypyr, Fluroxypyr-Butometyl, Fluroxypyr-Meptyl, Flurtamon, Fluthiacet, Fluthiacet-Methyl, Fomesafen, Fomesafen-Natrium, Foramsulfuron, Foramsulfuron-Natrium, Fosamine, Fosamine-Ammonium, Glufosinat, Glufosinat-Ammonium, Glufosinat-Natrium, L- BCS241005-Ausland STR 258 Glufosinat-Ammonium, L-Glufosinat-Natrium, Glufosinat-P-Natrium, Glufosinat-P-Ammonium, Glyphosat, Glyphosat-Ammonium, Glyphosat-Isopropylammonium, Glyphosat-Diammonium, Glyphosat-Dimethylammonium, Glyphosat-Kalium, Glyphosat-Natrium, Glyphosat-Sesquinatrium und Glyphosat-Trimesium, H-9201, d.h. O-(2,4-Dimethyl-6-nitrophenyl)-O-ethyl- 5 isopropylphosphoramidothioat, Halauxifen, Halauxifen-methyl, Halosafen, Halosulfuron, Halosulfuron- Methyl, Haloxyfop, Haloxyfop-P, Haloxyfop-Ethoxyethyl, Haloxyfop-P-Ethoxyethyl, Haloxyfop- Methyl, Haloxyfop-P-Methyl, Haloxifop-Natrium, Hexazinon, HNPC-A8169, d.h. Prop-2-in-1-yl (2S)- 2-{3-[(5-tert-butylpyridin-2-yl)oxy]phenoxy}propanoat, HW-02, d.h.1-(Dimethoxyphosphoryl)-ethyl- (2,4-dichlorphenoxy)acetat, Hydantocidin, Icafolin, Icafolin-Methyl, Imazamethabenz, 10 Imazamethabenz-Methyl, Imazamox, Imazamox-Ammonium, Imazapic, Imazapic-Ammonium, Imazapyr, Imazapyr-Isopropylammonium, Imazaquin, Imazaquin-Ammonium, Imazaquin-Methyl, Imazethapyr, Imazethapyr-Ammonium, Imazosulfuron, Indanofan, Indaziflam, Indolauxipyr, Iodosulfuron, Iodosulfuron-Methyl, Iodosulfuron-Methyl-Natrium, Ioxynil, Ioxynil-Lithium, -Octanoat, -Kalium und Natrium, Ipfencarbazon, Iptriazopyrid, d.h. 3-[(Isopropylsulfonyl)methyl]-N-(5-methyl- 15 1,3,4-oxadiazol-2-yl)-5-(trifluormethyl)[1,2,4]triazolo-[4,3-a]pyridin-8-carboxamid, Isoproturon, Isouron, Isoxaben, Isoxaflutole, Karbutilat, KUH-043, d.h.3-({[5-(Difluormethyl)-1-methyl-3- (trifluormethyl)-1H-pyrazol-4-yl]methyl}sulfonyl)-5,5-dimethyl-4,5-dihydro-1,2-oxazol, Ketospiradox, Ketospiradox-Kalium, Lactofen, Lenacil, Linuron, MCPA, MCPA-Butotyl, -Butyl, -Dimethyl- ammonium, -Diolamin, -2-Ethylhexyl, -Ethyl, -Isobutyl, Isoctyl, -Isopropyl, -Isopropylammonium, - 20 Methyl, Olamin, -Kalium, –Natrium und -Trolamin, MCPB, MCPB-Methyl, -Ethyl und -Natrium, Mecoprop, Mecoprop-Butotyl, Mecoprop- dimethylammonium, Mecoprop-Diolamin, Mecoprop-Etexyl, Mecoprop-Ethadyl, Mecoprop-Isoctyl, Mecoprop-Methyl, Mecoprop-Kalium, Mecoprop-Natrium, und Mecoprop-Trolamin, Mecoprop-P, Mecoprop-P-Butotyl, -Dimethylammonium, -2-Ethylhexyl und - Kalium, Mefenacet, Mefluidid, Mefluidid-Diolamin, Mefluidid-Kalium, Mesosulfuron, Mesosulfuron- 25 Methyl, Mesosulfuron-Natrium, Mesotrion, Methabenzthiazuron, Metam, Metamifop, Metamitron, Metazachlor, Metazosulfuron, Methabenzthiazuron, Methiopyrsulfuron, Methiozolin, Methyl isothiocyanat, Metobromuron, Metolachlor, S-Metolachlor, Metosulam, Metoxuron, Metproxybicyclon, Metribuzin, Metsulfuron, Metsulfuron-Methyl, Molinat, Monolinuron, Monosulfuron, Monosulfuron- Methyl, MT-5950, d.h. N-[3-Chlor-4-(1-methylethyl)-phenyl]-2-methylpentanamid, NGGC-011, 30 Napropamid, NC-310, d.h.4-(2,4-Dichlorbenzoyl)-1-methyl-5-benzyloxypyrazol, Neburon, Nicosulfuron, Nonansäure (Pelargonsäure), Norflurazon, Ölsäure (Fettsäuren), Orbencarb, Orthosulfamuron, Oryzalin, Oxadiargyl, Oxadiazon, Oxasulfuron, Oxaziclomefone, Oxyfluorfen, Paraquat, Paraquat-dichlorid, Paraquat-Dimethylsulfat, Pebulat, Pendimethalin, Penoxsulam, Pentachlorphenol, Pentoxazon, Pethoxamid, Petroleumöl, Phenmedipham, Phenmedipham-Ethyl, 35 Picloram, Picloram-dimethylammonium, Picloram-Etexyl, Picloram-Isoctyl, Picloram-Methyl, Picloram-Olamin, Picloram-Kalium, Picloram-Triethylammonium, Picloram-Tripromin, Picloram- Trolamin, Picolinafen, Pinoxaden, Piperophos, Pretilachlor, Primisulfuron, Primisulfuron-Methyl, BCS241005-Ausland STR 259 Prodiamine, Profoxydim, Prometon, Prometryn, Propachlor, Propanil, Propaquizafop, Propazine, Propham, Propisochlor, Propoxycarbazone, Propoxycarbazone-Natrium, Propyrisulfuron, Propyzamid, Prosulfocarb, Prosulfuron, Pyraclonil, Pyraflufen, Pyraflufen-Ethyl, Pyraquinat, Pyrasulfotol, Pyrazolynat (Pyrazolat), Pyrazosulfuron, Pyrazosulfuron-Ethyl, Pyrazoxyfen, Pyribambenz, 5 Pyribambenz-Isopropyl, Pyribambenz-Propyl, Pyribenzoxim, Pyributicarb, Pyridafol, Pyridat, Pyriftalid, Pyriminobac, Pyriminobac-Methyl, Pyrimisulfan, Pyrithiobac, Pyrithiobac-Natrium, Pyroxasulfon, Pyroxsulam, Quinclorac, Quinclorac-Dimethylammonium, Quinclorac-Methyl, Quinmerac, Quinoclamin, Quizalofop, Quizalofop-Ethyl, Quizalofop-P, Quizalofop-P-Ethyl, Quizalofop-P-Tefuryl, QYM201, d.h.1-{2-Chlor-3-[(3-cyclopropyl-5-hydroxy-1-methyl-1H-pyrazol-4-yl)carbonyl]-6- 10 (trifluormethyl)phe-nyl}piperidin-2-on, Rimisoxafen, Rimsulfuron, Saflufenacil, Sethoxydim, Siduron, Simazine, Simetryn, SL-261, Sulcotrione, Sulfentrazone, Sulfometuron, Sulfometuron-Methyl, Sulfosulfuron, , SYP-249, d.h.1-Ethoxy-3-methyl-1-oxobut-3-en-2-yl-5-[2-chlor-4- (trifluormethyl)phenoxy]-2-nitrobenzoat, SYP-300, d.h.1-[7-Fluor-3-oxo-4-(prop-2-in-1-yl)-3,4- dihydro-2H-1,4-benzoxazin-6-yl]-3-propyl-2-thioxoimidazolidin-4,5-dion, 2,3,6-TBA, TCA 15 (Trichloressigsäure) und seine Salze, z.B. TCA-ammonium, TCA-Calcium, TCA-Ethyl, TCA- Magnesium, TCA-Natrium, Tebuthiuron, Tefuryltrione, Tembotrion, Tepraloxydim, Terbacil, Terbucarb, Terbumeton, Terbuthylazine, Terbutryn, Tetflupyrolimet, Thaxtomin, Thenylchlor, Thiazopyr, Thiencarbazone, Thiencarbazon-Methyl, Thifensulfuron, Thifensulfuron-Methyl, Thiobencarb, Tiafenacil, Tolpyralat, Topramezon, Tralkoxydim, Triafamon, Tri-allat, Triasulfuron,20 Triaziflam, Tribenuron, Tribenuron-Methyl, Triclopyr, Triclopyr-Butotyl, Triclopyr-Cholin, Triclopyr- Ethyl, Triclopyr-Triethylammonium, Trietazine, Trifloxysulfuron, Trifloxysulfuron-Natrium, Trifludimoxazin, Trifluralin, Triflusulfuron, Triflusulfuron-Methyl, Tritosulfuron, Harnstoffsulfat, Vernolat, XDE-848, ZJ-0862, d.h.3,4-Dichlor-N-{2-[(4,6-dimethoxypyrimidin-2-yl)oxy]benzyl}anilin, 3-(2-Chlor-4-fluor-5-(3-methyl-2,6-dioxo-4-trifluormethyl-3,6-dihydropyrimidin-1(2H)-yl)phenyl)-5-25 methyl-4,5-dihydroisoxazol-5-carbonsäuremethylester, 3-(2-Chlor-4-fluor-5-(3-methyl-2,6-dioxo-4- trifluormethyl-3,6-dihydropyrimidin-1(2H)-yl)phenyl)-5-methyl-4,5-dihydroisoxazol-5- carbonsäureethylester, 3-(2-Chlor-4-fluor-5-(3-methyl-2,6-dioxo-4-trifluormethyl-3,6-dihydropyrimidin- 1(2H)-yl)phenyl)-5-methyl-4,5-dihydroisoxazol-5-carbonsäure, Ethyl-[(3-{2-chlor-4-fluor-5-[3-methyl- 2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenoxy}pyridin-2-yl)oxy]acetat, 3-Chlor-30 2-[3-(difluormethyl)isoxazolyl-5-yl]phenyl-5-chlorpyrimidin-2-ylether, 2-(3,4-Dimethoxyphenyl)-4-[(2- hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-6-methylpyridazin-3(2H)-on, 2-({2-[(2- Methoxyethoxy)methyl]-6-methylpyridin-3-yl}carbonyl)cyclohexane-1,3-dion, (5-Hydroxy-1-methyl- 1H-pyrazol-4-yl)(3,3,4-trimethyl-1,1-dioxido-2,3-dihydro-1-benzothiophen-5-yl)methanon, 1-Methyl-4- [(3,3,4-trimethyl-1,1-dioxido-2,3-dihydro-1-benzothiophen-5-yl)carbonyl]-1H-pyrazol-5-yl propan-1-35 sulfonat, 4-{2-Chlor-3-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-4-(methylsulfonyl)benzoyl}-1-methyl- 1H-pyrazol-5-yl-1,3-dimethyl-1H-pyrazol-4-carboxylat; Cyanomethyl-4-amino-3-chlor-5-fluor-6-(7- fluor-1H-indol-6-yl)pyridin-2-carboxylat, Prop-2-yn-1-yl 4-amino-3-chlor-5-fluor-6-(7-fluor-1H-indol- BCS241005-Ausland STR 260 6-yl)pyridin-2-carboxylat, Methyl-4-amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridin-2- carboxylat, Benzyl-4-amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridin-2-carboxylat, Ethyl-4- amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridin-2-carboxylat, Methyl-4-amino-3-chlor-5-fluor- 6-(7-fluor-1-isobutyryl-1H-indol-6-yl)pyridin-2-carboxylat, Methyl 6-(1-acetyl-7-fluor-1H-indol-6-yl)- 5 4-amino-3-chlor-5-fluorpyridin-2-carboxylat, Methyl-4-amino-3-chlor-6-[1-(2,2-dimethylpropanoyl)-7- fluor-1H-indol-6-yl]-5-fluorpyridin-2-carboxylat, Methyl-4-amino-3-chlor-5-fluor-6-[7-fluor-1- (methoxyacetyl)-1H-indol-6-yl]pyridin-2-carboxylat, Kalium 4-amino-3-chlor-5-fluor-6-(7-fluor-1H- indol-6-yl)pyridin-2-carboxylat, Natrium-4-amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridin-2- carboxylat, Butyl-4-amino-3-chlor-5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridin-2-carboxylat, 4-Hydroxy-10 1-methyl-3-[4-(trifluoromethyl)pyridin-2-yl]imidazolidin-2-on, 3-(5-tert-butyl-1,2-oxazol-3-yl)-4- hydroxy-1-methylimidazolidin-2-on, 3-[5-Chlor-4-(trifluormethyl)pyridin-2-yl]-4-hydroxy-1- methylimidazolidin-2-on, 4-Hydroxy-1-methoxy-5-methyl-3-[4-(trifluormethyl)pyridin-2- yl]imidazolidin-2-on, 6-[(2-Hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-1,5-dimethyl-3-(2- methylphenyl)chinazolin-2,4(1H,3H)-dion, 3-(2,6-Dimethylphenyl)-6-[(2-hydroxy-6-oxocyclohex-1-en-15 1-yl)carbonyl]-1-methylchinazolin-2,4(1H,3H)-dion, 2-[2-chlor-4-(methylsulfonyl)-3-(morpholin-4- ylmethyl)benzoyl]-3-hydroxycyclohex-2-en-1-on, 1-(2-carboxyethyl)-4-(pyrimidin-2-yl)pyridazin-1- iumsalz (mit passenden Anionen wie z.B Chlorid, Acetat oder Trifluoracetat), 1-(2-Carboxyethyl)-4- (pyridazin-3-yl)pyridazin-1-iumsalz (mit passenden Anionen wie z.B. Chlorid, Acetat oder Trifluoracetat), 4-(Pyrimidin-2-yl)-1-(2-sulfoethyl)pyridazin-1-ium salz (mit passenden Anionen wie 20 z.B Chlorid, Acetat oder Trifluoracetat), 4-(Pyridazin-3-yl)-1-(2-sulfoethyl)pyridazin-1-iumsalz (mit passenden Anionen wie z.B Chlorid, Acetat oder Trifluoracetat), 1-(2-Carboxyethyl)-4-(1,3-thiazol-2- yl)pyridazin-1-iumsalz (mit passenden Anionen wie z.B Chlorid, Acetat oder Trifluoracetat), 1-(2- Carboxyethyl)-4-(1,3,4-thiadiazol-2-yl)pyridazin-1-iumsalz (mit passenden Anionen wie z.B Chlorid, Acetat oder Trifluoracetat), Methyl (2R)-2-{[(E)-({2-chlor-4-fluor-5-[3-methyl-2,6-dioxo-4-25 (trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}methyliden)amino]oxy}propanoat, Methyl (2S)- 2-{[(E)-({2-chlor-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)- yl]phenyl}methyliden)amino]oxy}propanoat, Methyl (2R/S)-2-{[(E)-({2-chlor-4-fluor-5-[3-methyl-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}methyliden)amino]oxy}propanoat, (E)- 2-(Trifluormethyl)benzaldehyd-O-{2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoyl}oxim, 2-Fluor-30 N-(5-methyl-1,3,4-oxadiazol-2-yl)-3-[(R)-propylsulfinyl]-4-(trifluormethyl)benzamid, (2R)-2-[(4- Amino-3,5-dichlor-6-fluor-2-pyridyl)oxy]propancarbonsäure, 2-Ethoxy-2-oxoethyl-1-{2-chlor-4-fluor- 5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)- yl]phenoxy}cyclopropancarboxylat, 2-Methoxy-2-oxoethyl-1-{2-chlor-4-fluor-5-[3-methyl-2,6-dioxo-4- (trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenoxy}cyclopropancarboxylat, {[(1-{2-Chlor-4-35 fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)- yl]phenoxy}cyclopropyl)carbonyl]oxy}essigsäure, 2-(2-Brom-4-chlorbenzyl)-4,4-dimethyl-1,2- oxazolidin-3-on, Methyl 3-{2-chlor-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6- BCS241005-Ausland STR 261 dihydropyrimidin-1(2H)-yl]phenyl}-3a,4,5,6-tetrahydro-6aH-cyclopenta[d][1,2]oxazol-6a-carboxylat, Ethyl 3-{2-chlor-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)- yl]phenyl}-3a,4,5,6-tetrahydro-6aH-cyclopenta[d][1,2]oxazol-6a-carboxylat, Methyl-3-{2-chlor-4-fluor- 5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-6-methyl-3a,4,5,6- 5 tetrahydro-6aH-cyclopenta[d][1,2]oxazol-6a-carboxylat, 3-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4- (trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-6-methyl-3a,4,5,6-tetrahydro-6aH- cyclopenta[d][1,2]oxazol-6a-carbonsäure, 3-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)- 3,6-dihydropyrimidin-1(2H)-yl]phenyl}-3a,4,5,6-tetrahydro-6aH-cyclopenta[d][1,2]oxazol-6a- carbonsäure 10 Beispiele für Pflanzenwachstumsregulatoren als mögliche Mischungspartner sind: Abscisinsäure und verwandte Analoga [z.B. (2Z,4E)-5-[6-Ethynyl-1-hydroxy-2,6-dimethyl-4-oxocyclohex-2-en-1-yl]-3- methylpenta-2,4-diensäure, methyl-(2Z,4E)-5-[6-ethynyl-1-hydroxy-2,6-dimethyl-4-oxocyclohex-2-en- 1-yl]-3-methylpenta-2,4-dienoat, (2Z,4E)-3-ethyl-5-(1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-15 yl)penta-2,4-diensäure, (2E,4E)-5-(1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl)-3- (trifluoromethyl)penta-2,4-diensäure, methyl (2E,4E)-5-(1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2- en-1-yl)-3-(trifluoromethyl)penta-2,4-dienoat, (2Z,4E)-5-(2-hydroxy-1,3-dimethyl-5- oxobicyclo[4.1.0]hept-3-en-2-yl)-3-methylpenta-2,4-diensäure], Acibenzolar, Acibenzolar-S-methyl, S- Adenosylhomocystein, Allantoin, 2-Aminoethoxyvinylglycin (AVG), Aminooxyessigsäure and 20 verwandte Ester [z.B. (Isopropyliden)-aminooxyessigsäure-2-(methoxy)-2-oxoethylester, (Isopropyliden)-aminooxyessigsäure-2-(hexyloxy)-2-oxoethylester, (Cyclohexyliden)- aminooxyessigsäure-2-(isopropyloxy)-2-oxoethylester], 1-Aminocycloprop-1-ylcarbonsäure N-Methyl- 1-aminocyclopropyl-1-carbonsäure, 1-Aminocyclopropyl-1-carbonsäureamid, substituierte 1- Aminocyclopropyl-1-carbonsäurederivate wie sie in DE3335514, EP30287, DE2906507 oder 25 US5123951 beschrieben werden, 1-Aminocyclopropyl-1-hydroxamsäure, 5-Aminolevulinsäure, Ancymidol, 6-Benzylaminopurin, Bikinin, Brassinolid, Brassinolide-ethyl, L-Canalin, Catechin und catechine (z.B. (2S,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-chromen-3,5,7-triol), Chitooligosaccharides (CO; COs unterscheiden sich von LCOs dadurch, daß ihnen die für LCOs charakteristische Fettsäureseitenkette fehlt. COs, in manchen Fällen als N-Acetylchitooligosaccharide 30 bezeichnet, sind auch aus GlcNAc-Einheiten aufgebaut, aber haben Seitenketten, durch die sies ich von Chitinmolekülen unterscheiden [(C8H13NO5)n, CAS No.1398-61-4] und chitosan Moleküle [(C5H11NO4)n, CAS No.9012-76-4]), Chitin-artige Verbindungen, Chlormequat chloride, Cloprop, Cyclanilide, 3-(Cycloprop-1-enyl)propionsäure, 1-[2-(4-Cyano-3,5- dicyclopropylphenyl)acetamido]cyclohexancarbonsäure, 1-[2-(4-Cyano-3- 35 cyclopropylphenyl)acetamido]cyclohexancarbonsäure, 1-Cyclopropenylmethanol, Daminozid, Dazomet, Dazomet-Natrium, n-Decanol, Dikegulac, Dikegulac-Natrium, Endothal, Endothal-di-Kalium, -di- Natrium, und mono(N,N-dimethylalkylammonium), Ethephon, 1-Ethylcyclopropen,Flumetralin, BCS241005-Ausland STR 262 Flurenol, Flurenol-butyl, Flurenol-methyl, Flurprimidol, Forchlorfenuron, Gibberellinsäure, Inabenfid, Indol-3-essigsäure (IAA), 4-Indol-3-ylbuttersäure, Isoprothiolan, Probenazole, Jasmonsäure, Jasmonsäureester oder andere Derivate (z.B. Jasmonsäuremethylester, Jasmonsäureethylester), Lipochitooligosaccharide (LCO, in manchen Fällen auch als Symbiotische Nodulationssignale (Nod 5 oder Nod Faktoren) oder als Myc Faktoren bezeichnet, bestehen aus einem Oligosacchariderückgrat aus β-l,4-verknüpften N-Acetyl-D-Glucosaminresten (“GlcNAc”) mit einer N-verknüpften Fettsäureseitenkette, die am nicht reduzierenden Ende ankondensiert ist. Wie aus der Literatur zu entnehmen ist, unterscheiden sich LCOs in der Zahl an GlcNAc-EInheiten in der Rückgratstruktur, in der Länge und dem Sättigungsgrad der Fettsäurekette sowie in der Substitution der reduzierenden und 10 nicht-reduzierenden Zuckereinheiten), Linoleinsäure oder ihre Derivate, Linolensäure oder ihre Derivate, Maleinsäurehydrazid, Mepiquatchlorid, Mepiquatpentaborat, 1-Methylcyclopropen, 3- Methylcyclopropen, Methoxyvinylglycin (MVG), 3’-Methylabscisinsäure, 1-(4-Methylphenyl)-N-(2- oxo-1-propyl-1,2,3,4-tetrahydrochinolin-6-yl)methansulfonamid und verwandte substituierte (Tetrahydrochinolin-6-yl)methansulfonamide, (3E,3aR,8bS)-3-({[(2R)-4-Methyl-5-oxo-2,5- 15 dihydrofuran-2-yl]oxy}methylen)-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]furan-2-on und verwandte Laktone wie sie in EP2248421 beschrieben sind, 2-(1-Naphthyl)acetamid, 1-Naphthylessigsäure, 2- Naphthyloxyessigsäure, Nitrophenolatmischung, 4-Oxo-4[(2-phenylethyl)amino]buttersäure, Paclobutrazol, 4-Phenylbuttersäure and ihre Salze (z.B. Natrium-4-phenylbutanoat, Kalium-4- phenylbutanoat), Phenylalanine, N-Phenylphthalamsäure, Prohexadione, Prohexadion-Calcium, , 1-n- 20 Propylcyclopropen, Putrescin, Prohydrojasmon, Rhizobitoxin, Salicylsäure und Salicyclsäuremethylester, Sarcosin, Natriumcycloprop-1-en-1-ylacetat, Natriumcycloprop-2-en-1- ylacetat, Natrium-3-(cycloprop-2-en-1-yl)propanoat, Natrium-3-(cycloprop-1-en-1-yl)propanoat, Sidefungin, Spermidin, Spermine, Strigolactone, Tecnazene, Thidiazuron, Triacontanol, Trinexapac, Trinexapac-ethyl, Tryptophan, Tsitodef, Uniconazol, Uniconazol-P, 2-Fluoro-N-(3-methoxyphenyl)-9H- 25 purin-6-amin, 2-chloro-N-(3-methoxyphenyl)-9H-purin-6-amin. Ebenfalls als Kombinationspartner für die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) kommen beispielsweise die folgenden Safener in Frage: S1) Verbindungen der Formel (S1), 30 wobei die Symbole und Indizes folgende Bedeutungen haben: nA ist eine natürliche Zahl von 0 bis 5, vorzugsweise 0 bis 3; BCS241005-Ausland STR 263 RA 1 ist Halogen, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, Nitro oder (C1-C4)-Haloalkyl; WA ist ein unsubstituierter oder substituierter divalenter heterocyclischer Rest aus der Gruppe der teilungesättigten oder aromatischen Fünfring-Heterocyclen mit 1 bis 3 Heteroringatomen aus der 5 Gruppe N und O, wobei mindestens ein N-Atom und höchstens ein O-Atom im Ring enthalten ist, vorzugsweise ein Rest aus der Gruppe (WA 1) bis (WA 5), mA ist 0 oder 1; RA 2 ist ORA 3, SRA 3 oder NRA 3RA 4 oder ein gesättigter oder ungesättigter 3- bis 7-gliedriger Heterocyclus mit mindestens einem N-Atom und bis zu 3 Heteroatomen, vorzugsweise aus der 10 Gruppe O und S, der über das N-Atom mit der Carbonylgruppe in (S1) verbunden ist und unsubstituiert oder durch Reste aus der Gruppe (C1-C4)-Alkyl, (C1-C4)-Alkoxy oder gegebenenfalls substituiertes Phenyl substituiert ist, vorzugsweise ein Rest der Formel ORA 3, NHRA 4 oder N(CH3)2, insbesondere der Formel ORA 3; RA 3 ist Wasserstoff oder ein unsubstituierter oder substituierter aliphatischer Kohlenwasserstoffrest, 15 vorzugsweise mit insgesamt 1 bis 18 C-Atomen; RA 4 ist Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Alkoxy oder substituiertes oder unsubstituiertes Phenyl; RA 5 ist H, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C1-C4)-Alkoxy(C1-C8)-Alkyl, Cyano oder COORA 9, worin RA 9 Wasserstoff, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C1-C4)-Alkoxy-(C1-C4)-alkyl, (C1-C6)-Hydroxyalkyl, (C3-C12)-Cycloalkyl oder Tri-(C1-C4)-alkyl-silyl ist; 20 RA 6, RA 7, RA 8 sind gleich oder verschieden Wasserstoff, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C3-C12)-Cycloalkyl oder substituiertes oder unsubstituiertes Phenyl; RA 10 ist H, (C3-C12)-Cycloalkyl, substituiertes oder unsubstituiertes Phenyl oder substituiertes oder unsubstituiertes Heteroaryl; vorzugsweise: 25 a) Verbindungen vom Typ der Dichlorphenylpyrazolin-3-carbonsäure (S1a), vorzugsweise Verbindungen wie 1-(2,4-Dichlorphenyl)-5-(ethoxycarbonyl)-5-methyl- 2-pyrazolin-3-carbonsäure, BCS241005-Ausland STR 264 1-(2,4-Dichlorphenyl)-5-(ethoxycarbonyl)-5-methyl-2-pyrazolin-3-carbonsäureethylester (S1-1) ("Mefenpyr-diethyl"), und verwandte Verbindungen, wie sie in der WO-A-91/07874 beschrieben sind; b) Derivate der Dichlorphenylpyrazolcarbonsäure (S1b), vorzugsweise Verbindungen wie 1-(2,4-Dichlorphenyl)-5-methyl-pyrazol-3-carbonsäureethylester (S1-2), 1-(2,4-Di- 5 chlorphenyl)-5-isopropyl-pyrazol-3-carbonsäureethylester (S1-3), 1-(2,4-Dichlor- phenyl)-5-(1,1-dimethyl-ethyl)pyrazol-3-carbonsäureethyl-ester (S1-4) und verwandte Verbindungen, wie sie in EP-A-333131 und EP-A-269806 beschrieben sind; c) Derivate der 1,5-Diphenylpyrazol-3-carbonsäure (S1c), vorzugsweise Verbindungen wie 1-(2,4-Dichlorphenyl)-5-phenylpyrazol-3-carbonsäureethylester (S1-5), 10 1-(2-Chlorphenyl)-5-phenylpyrazol-3-carbonsäuremethylester (S1-6) und verwandte Verbindungen wie sie beispielsweise in der EP-A-268554 beschrieben sind; d) Verbindungen vom Typ der Triazolcarbonsäuren (S1d), vorzugsweise Verbindungen wie Fenchlorazol(-ethylester), d.h.1-(2,4-Dichlorphenyl)-5-trichlormethyl-(1H)-1,2,4-triazol-3-carbonsäure- ethylester (S1-7), und verwandte Verbindungen wie sie in EP-A-174562 und EP-A-346620 15 beschrieben sind; e) Verbindungen vom Typ der 5-Benzyl- oder 5-Phenyl-2-isoxazolin-3- carbonsäure oder der 5,5- Diphenyl-2-isoxazolin-3-carbonsäure (S1e), vorzugsweise Verbindungen wie 5-(2,4-Dichlorbenzyl)-2-isoxazolin-3-carbonsäureethylester (S1-8) oder 5-Phenyl-2-isoxazolin-3- carbonsäureethylester (S1-9) und verwandte Verbindungen, wie sie in WO-A-91/08202 beschrieben20 sind, bzw.5,5-Diphenyl-2-isoxazolin-3-carbonsäure (S1-10) oder 5,5-Diphenyl-2-isoxazolin-3- carbonsäureethylester (S1-11) ("Isoxadifen-ethyl") oder -n-propylester (S1-12) oder der 5-(4-Fluorphenyl)-5-phenyl-2-isoxazolin-3-carbonsäureethylester (S1-13), wie sie in der Patentanmeldung WO-A-95/07897 beschrieben sind. f) Verbindungen vom Typ der Triazolyloxyessigsäurederivate (S1f), vorzugsweise Verbindungen wie25 Methyl-{[1,5-bis(4-chlor-2-fluorphenyl)-1H-1,2,4-triazol-3-yl]oxy}acetat (S1-14) oder {[1,5-Bis(4- chlor-2-fluorphenyl)-1H-1,2,4-triazol-3-yl]oxy}essigsäure (S1-15) oder Methyl-{[5-(4-chlor-2- fluorphenyl)-1-(2,4-difluorphenyl)-1H-1,2,4-triazol-3-yl]oxy}acetat (S1-16) oder {[5-(4-Chlor-2- fluorphenyl)-1-(2,4-difluorphenyl)-1H-1,2,4-triazol-3-yl]oxy}essigsäure (S1-17) oder Methyl-{[1-(4- chlor-2-fluorphenyl)-5-(2,4-difluorphenyl)-1H-1,2,4-triazol-3-yl]oxy}acetat (S1-18) oder {[1-(4-Chlor- 30 2-fluorphenyl)-5-(2,4-difluorphenyl)-1H-1,2,4-triazol-3-yl]oxy}essigsäure (S1-19), wie sie in der Patentanmeldung WO2021105101 beschrieben sind BCS241005-Ausland STR 265 S2) Chinolinderivate der Formel (S2), wobei die Symbole und Indizes folgende Bedeutungen haben: RB 1 ist Halogen, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, Nitro oder (C1-C4)-Haloalkyl; 5 nB ist eine natürliche Zahl von 0 bis 5, vorzugsweise 0 bis 3; RB 2 ist ORB 3, SRB 3 oder NRB 3RB 4 oder ein gesättigter oder ungesättigter 3- bis 7-gliedriger Heterocyclus mit mindestens einem N-Atom und bis zu 3 Heteroatomen, vorzugsweise aus der Gruppe O und S, der über das N-Atom mit der Carbonylgruppe in (S2) verbunden ist und unsubstituiert oder durch Reste aus der Gruppe (C1-C4)-Alkyl, (C1-C4)-Alkoxy 10 oder gegebenenfalls substituiertes Phenyl substituiert ist, vorzugsweise ein Rest der Formel ORB 3, NHRB 4 oder N(CH3)2, insbesondere der Formel ORB 3; RB 3 ist Wasserstoff oder ein unsubstituierter oder substituierter aliphatischer Kohlenwasserstoffrest, vorzugsweise mit insgesamt 1 bis 18 C-Atomen; RB 4 ist Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Alkoxy oder substituiertes oder unsubstituiertes Phenyl; 15 TB ist eine (C1 oder C2)-Alkandiylkette, die unsubstituiert oder mit einem oder zwei (C1-C4)-Alkylresten oder mit [(C1-C3)-Alkoxy]-carbonyl substituiert ist; vorzugsweise: a) Verbindungen vom Typ der 8-Chinolinoxyessigsäure (S2a), vorzugsweise (5-Chlor-8-chinolinoxy)essigsäure-(1-methylhexyl)ester ("Cloquintocet-mexyl") (S2-1), (5-Chlor-8-20 chinolinoxy)essigsäure-(1,3-dimethyl-but-1-yl)ester (S2-2), (5-Chlor-8-chinolinoxy)essigsäure-4- allyloxy-butylester (S2-3), (5-Chlor-8-chinolin-oxy)essigsäure-1-allyloxy-prop-2-ylester (S2-4), (5- Chlor-8-chinolinoxy)essigsäure-ethylester (S2-5), (5-Chlor-8-chinolinoxy)essigsäuremethylester (S2-6), (5-Chlor-8-chinolinoxy)essigsäureallylester (S2-7), (5-Chlor-8-chinolinoxy)essigsäure-2-(2-propyliden- iminoxy)-1-ethylester (S2-8), (5-Chlor-8-chinolinoxy)essigsäure-2-oxo-prop-1-ylester (S2-9) und 25 verwandte Verbindungen, wie sie in EP-A-86750, EP-A-94349 und EP-A-191736 oder EP-A-0492 366 beschrieben sind, sowie (5-Chlor-8-chinolinoxy)essigsäure (S2-10), deren Hydrate und Salze, BCS241005-Ausland STR 266 beispielsweise deren Lithium-, Natrium- Kalium-, Kalzium-, Magnesium-, Aluminium-, Eisen-, Ammonium-, quartäre Ammonium-, Sulfonium-, oder Phosphoniumsalze wie sie in der WO-A- 2002/34048 beschrieben sind; b) Verbindungen vom Typ der (5-Chlor-8-chinolinoxy)malonsäure (S2b), vorzugsweise 5 Verbindungen wie (5-Chlor-8-chinolinoxy)malonsäurediethylester, (5-Chlor- 8-chinolinoxy)- malonsäurediallylester, (5-Chlor-8-chinolinoxy)malonsäure-methyl-ethylester und verwandte Verbindungen, wie sie in EP-A-0582198 beschrieben sind. S3) Verbindungen der Formel (S3) 10 wobei die Symbole und Indizes folgende Bedeutungen haben: RC 1 ist (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C2-C4)-Alkenyl, (C2-C4)-Haloalkenyl, (C3-C7)-Cycloalkyl, vorzugsweise Dichlormethyl; RC 2, RC 3 sind gleich oder verschieden Wasserstoff, (C1-C4)-Alkyl, (C2-C4)-Alkenyl, (C2-C4)Alkinyl, (C1- C4)Haloalkyl, (C2-C4)Haloalkenyl, (C1-C4)Alkylcarbamoyl-(C1-C4)alkyl, (C2-C4)Alkenyl- 15 carbamoyl-(C1-C4)alkyl, (C1-C4)Alkoxy-(C1-C4)alkyl, Dioxolanyl-(C1-C4)alkyl, Thiazolyl, Furyl, Furylalkyl, Thienyl, Piperidyl, substituiertes oder unsubstituiertes Phenyl, oder RC 2 und RC 3 bilden zusammen einen substituierten oder unsubstituierten heterocyclischen Ring, vorzugsweise einen Oxazolidin-, Thiazolidin-, Piperidin-, Morpholin-, Hexahydropyrimidin- oder Benzoxazinring; vorzugsweise: Wirkstoffe vom Typ der Dichloracetamide, die häufig als 20 Vorauflaufsafener (bodenwirksame Safener) angewendet werden, wie z. B. "Dichlormid" (N,N-Diallyl-2,2-dichloracetamid) (S3-1), "R-29148" (3-Dichloracetyl-2,2,5- trimethyl-1,3-oxazolidin) der Firma Stauffer (S3-2), "R-28725" (3-Dichloracetyl-2,2,-dimethyl- 1,3-oxazolidin) der Firma Stauffer (S3-3), "Benoxacor" (4-Dichloracetyl-3,4-dihydro-3-methyl- 2H-1,4-benzoxazin) (S3-4), "PPG-1292" (N-Allyl-N-[(1,3-dioxolan-2-yl)-methyl]-25 dichloracetamid) der Firma PPG Industries (S3-5), "DKA-24" (N-Allyl-N- [(allylaminocarbonyl)methyl]-dichloracetamid) der Firma Sagro-Chem (S3-6), "AD-67" oder "MON 4660" (3-Dichloracetyl-1-oxa-3-aza-spiro[4,5]decan) der Firma Nitrokemia bzw. Monsanto (S3-7), "TI-35" (1-Dichloracetyl-azepan) der Firma TRI-Chemical RT (S3-8), "Diclonon" (Dicyclonon) oder "BAS145138" oder "LAB145138" (S3-9) ((RS)-1-Dichloracetyl- 30 3,3,8a-trimethylperhydropyrrolo[1,2-a]pyrimidin-6-on) der Firma BASF, "Furilazol" oder BCS241005-Ausland STR 267 "MON 13900" ((RS)-3-Dichloracetyl-5-(2-furyl)-2,2-dimethyloxazolidin) (S3-10); sowie dessen (R)-Isomer (S3-11). S4) N-Acylsulfonamide der Formel (S4) und ihre Salze, 5 worin die Symbole und Indizes folgende Bedeutungen haben: XD ist CH oder N; RD 1 ist CO-NRD 5RD 6 oder NHCO-RD 7; RD 2 ist Halogen, (C1-C4)-Haloalkyl, (C1-C4)-Haloalkoxy, Nitro, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, (C1- 10 C4)-Alkylsulfonyl, (C1-C4)-Alkoxycarbonyl oder (C1-C4)-Alkylcarbonyl; RD 3 ist Wasserstoff, (C1-C4)-Alkyl, (C2-C4)-Alkenyl oder (C2-C4)-Alkinyl; RD 4 ist Halogen, Nitro, (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Haloalkoxy, (C3-C6)-Cycloalkyl, Phenyl, (C1-C4)-Alkoxy, Cyano, (C1-C4)-Alkylthio, (C1-C4)-Alkylsulfinyl, (C1-C4)- Alkylsulfonyl, (C1-C4)-Alkoxycarbonyl oder (C1-C4)-Alkylcarbonyl; 15 RD 5 ist Wasserstoff, (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C5-C6)- Cycloalkenyl, Phenyl oder 3- bis 6-gliedriges Heterocyclyl enthaltend vD Heteroatome aus der Gruppe Stickstoff, Sauerstoff und Schwefel, wobei die sieben letztgenannten Reste durch vD Substituenten aus der Gruppe Halogen, (C1-C6)-Alkoxy, (C1-C6)-Haloalkoxy, (C1-C2)- Alkylsulfinyl, (C1-C2)-Alkylsulfonyl, (C3-C6)-Cycloalkyl, (C1-C4)-Alkoxycarbonyl, (C1-C4)-20 Alkylcarbonyl und Phenyl und im Falle cyclischer Reste auch (C1-C4)-Alkyl und (C1-C4)- Haloalkyl substituiert sind; RD 6 ist Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl oder (C2-C6)-Alkinyl, wobei die drei letztgenannten Reste durch vD Reste aus der Gruppe Halogen, Hydroxy, (C1-C4)-Alkyl, (C1-C4)- Alkoxy und (C1-C4)-Alkylthio substituiert sind, oder 25 RD 5 und RD 6 gemeinsam mit dem dem sie tragenden Stickstoffatom einen Pyrrolidinyl- oder Piperidinyl- Rest bilden; BCS241005-Ausland STR 268 RD 7 ist Wasserstoff, (C1-C4)-Alkylamino, Di-(C1-C4)-alkylamino, (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, wobei die 2 letztgenannten Reste durch vD Substituenten aus der Gruppe Halogen, (C1-C4)- Alkoxy, (C1-C6)-Haloalkoxy und (C1-C4)-Alkylthio und im Falle cyclischer Reste auch (C1-C4)- Alkyl und (C1-C4)-Haloalkyl substituiert sind; 5 nD ist 0, 1 oder 2; mD ist 1 oder 2; vD ist 0, 1, 2 oder 3; davon bevorzugt sind Verbindungen vom Typ der N-Acylsulfonamide, z.B. der nachfolgenden Formel (S4a), die z. B. bekannt sind aus WO-A-97/45016 10 worin RD 7 (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, wobei die 2 letztgenannten Reste durch vD Substituenten aus der Gruppe Halogen, (C1-C4)-Alkoxy, (C1-C6)-Haloalkoxy und (C1-C4)-Alkylthio und im Falle 15 cyclischer Reste auch (C1-C4)-Alkyl und (C1-C4)-Haloalkyl substituiert sind; RD 4 Halogen, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, CF3; mD 1 oder 2; vD ist 0, 1, 2 oder 3 bedeutet; sowie Acylsulfamoylbenzoesäureamide, z.B. der nachfolgenden Formel (S4b), die z.B. bekannt sind aus 20 WO-A-99/16744, z.B. solche worin RD 5 = Cyclopropyl und (RD 4) = 2-OMe ist ("Cyprosulfamide", S4-1), BCS241005-Ausland STR 269 RD 5 = Cyclopropyl und (RD 4) = 5-Cl-2-OMe ist (S4-2), RD 5 = Ethyl und (RD 4) = 2-OMe ist (S4-3), RD 5 = Isopropyl und (RD 4) = 5-Cl-2-OMe ist (S4-4) und RD 5 = Isopropyl und (RD 4) = 2-OMe ist (S4-5). 5 sowie Verbindungen vom Typ der N-Acylsulfamoylphenylharnstoffe der Formel (S4c), die z.B. bekannt sind aus der EP-A-365484, worin 10 RD 8 und RD 9 unabhängig voneinander Wasserstoff, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C3-C6)-Alkenyl, (C3-C6)-Alkinyl, RD 4 Halogen, (C1-C4)Alkyl, (C1-C4)Alkoxy, CF3 mD 1 oder 2 bedeutet; beispielsweise 15 1-[4-(N-2-Methoxybenzoylsulfamoyl)phenyl]-3-methylharnstoff, 1-[4-(N-2-Methoxybenzoylsulfamoyl)phenyl]-3,3-dimethylharnstoff, 1-[4-(N-4,5-Dimethylbenzoylsulfamoyl)phenyl]-3-methylharnstoff. S5) Wirkstoffe aus der Klasse der Hydroxyaromaten und der aromatisch-aliphatischen 20 Carbonsäurederivate (S5), z.B.3,4,5-Triacetoxybenzoesäureethylester, 3,5-Di-methoxy-4- hydroxybenzoesäure, 3,5-Dihydroxybenzoesäure, 4-Hydroxysalicylsäure, 4-Fluorsalicyclsäure, 2- Hydroxyzimtsäure, 2,4-Dichlorzimtsäure, wie sie in der WO-A-2004/084631, WO-A-2005/015994, WO-A-2005/016001 beschrieben sind. S6) Wirkstoffe aus der Klasse der 1,2-Dihydrochinoxalin-2-one (S6), z.B. 25 1-Methyl-3-(2-thienyl)-1,2-dihydrochinoxalin-2-on, 1-Methyl-3-(2-thienyl)-1,2-dihydrochinoxalin-2- thion, 1-(2-Aminoethyl)-3-(2-thienyl)-1,2-dihydro-chinoxalin-2-on-hydrochlorid, 1-(2- BCS241005-Ausland STR 270 Methylsulfonylaminoethyl)-3-(2-thienyl)-1,2-dihydrochinoxa-lin-2-on, wie sie in der WO-A- 2005/112630 beschrieben sind. S7) Verbindungen der Formel (S7),wie sie in der WO-A-1998/38856 beschrieben sind 5 worin die Symbole und Indizes folgende Bedeutungen haben: RE 1, RE 2 sind unabhängig voneinander Halogen, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkyl, (C1- C4)-Alkylamino, Di-(C1-C4)-Alkylamino, Nitro; AE ist COORE 3 oder COSRE 4 RE 3, RE 4 sind unabhängig voneinander Wasserstoff, (C1-C4)-Alkyl, (C2-C6)-Alkenyl, (C2-C4)-Alkinyl, 10 Cyanoalkyl, (C1-C4)-Haloalkyl, Phenyl, Nitrophenyl, Benzyl, Halobenzyl, Pyridinylalkyl und Alkylammonium, nE 1 ist 0 oder 1 nE 2, nE 3 sind unabhängig voneinander 0, 1 oder 2, vorzugsweise Diphenylmethoxyessigsäure, Diphenylmethoxyessigsäureethylester, Diphenyl- 15 methoxyessigsäuremethylester (CAS-Reg.Nr.41858-19-9) (S7-1). S8) Verbindungen der Formel (S8),wie sie in der WO-A-98/27049 beschrieben sind worin XF CH oder N, nF für den Fall, dass XF=N ist, eine ganze Zahl von 0 bis 4 und 20 für den Fall, dass XF=CH ist, eine ganze Zahl von 0 bis 5, BCS241005-Ausland STR 271 RF 1 Halogen, (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy, Nitro, (C1- C4)-Alkylthio, (C1-C4)-Alkylsulfonyl, (C1-C4)-Alkoxycarbonyl, ggf. substituiertes. Phenyl, ggf. substituiertes Phenoxy, RF 2 Wasserstoff oder (C1-C4)-Alkyl, 5 RF 3 Wasserstoff, (C1-C8)-Alkyl, (C2-C4)-Alkenyl, (C2-C4)-Alkinyl, oder Aryl, wobei jeder der vorgenannten C-haltigen Reste unsubstituiert oder durch einen oder mehrere, vorzugsweise bis zu drei gleiche oder verschiedene Reste aus der Gruppe, bestehend aus Halogen und Alkoxy substituiert ist; bedeuten, oder deren Salze, vorzugsweise Verbindungen worin 10 XF CH, nF eine ganze Zahl von 0 bis 2, RF 1 Halogen, (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy, RF 2 Wasserstoff oder (C1-C4)-Alkyl, RF 3 Wasserstoff, (C1-C8)-Alkyl, (C2-C4)-Alkenyl, (C2-C4)-Alkinyl, oder Aryl, wobei jeder der 15 vorgenannten C-haltigen Reste unsubstituiert oder durch einen oder mehrere, vorzugsweise bis zu drei gleiche oder verschiedene Reste aus der Gruppe, bestehend aus Halogen und Alkoxy substituiert ist, bedeuten, oder deren Salze. S9) Wirkstoffe aus der Klasse der 3-(5-Tetrazolylcarbonyl)-2-chinolone (S9), z.B. 1,2-Dihydro-4-hydroxy-1-ethyl-3-(5-tetrazolylcarbonyl)-2-chinolon (CAS-Reg.Nr.219479-18-2), 1,2- 20 Dihydro-4-hydroxy-1-methyl-3-(5-tetrazolyl-carbonyl)-2-chinolon (CAS-Reg.Nr.95855-00-8), wie sie in der WO-A-1999/000020 beschrieben sind. S10) Verbindungen der Formeln (S10a) oder (S10b) wie sie in der WO-A-2007/023719 und WO-A-2007/023764 beschrieben sind BCS241005-Ausland STR 272 worin RG 1 Halogen, (C1-C4)-Alkyl, Methoxy, Nitro, Cyano, CF3, OCF3 YG, ZG unabhängig voneinander O oder S, nG eine ganze Zahl von 0 bis 4, 5 RG 2 (C1-C16)-Alkyl, (C2-C6)-Alkenyl, (C3-C6)-Cycloalkyl, Aryl; Benzyl, Halogenbenzyl, RG 3 Wasserstoff oder (C1-C6)-Alkyl bedeutet. S11) Wirkstoffe vom Typ der Oxyimino-Verbindungen (S11), die als Saatbeizmittel bekannt sind, wie z. B. "Oxabetrinil" ((Z)-1,3-Dioxolan-2-ylmethoxyimino(phenyl)acetonitril) (S11-1), das als Saatbeiz-Safener für Hirse gegen Schäden von Metolachlor bekannt ist, "Fluxofenim" (1-(4-10 Chlorphenyl)-2,2,2-trifluor-1-ethanon-O-(1,3-dioxolan-2-ylmethyl)-oxim) (S11-2), das als Saatbeiz- Safener für Hirse gegen Schäden von Metolachlor bekannt ist, und "Cyometrinil" oder "CGA-43089" ((Z)-Cyanomethoxyimino(phenyl)acetonitril) (S11-3), das als Saatbeiz-Safener für Hirse gegen Schäden von Metolachlor bekannt ist. S12) Wirkstoffe aus der Klasse der Isothiochromanone (S12), wie z.B. Methyl-[(3-oxo-1H-2- 15 benzothiopyran-4(3H)-yliden)methoxy]acetat (CAS-Reg.Nr.205121-04-6) (S12-1) und verwandte Verbindungen aus WO-A-1998/13361. S13) Eine oder mehrere Verbindungen aus Gruppe (S13): "Naphthalic anhydrid" (1,8-Naphthalindicarbonsäureanhydrid) (S13-1), das als Saatbeiz-Safener für Mais gegen Schäden von Thiocarbamatherbiziden bekannt ist, "Fenclorim" (4,6-Dichlor-2-phenylpyrimidin) (S13-2), das als20 Safener für Pretilachlor in gesätem Reis bekannt ist, "Flurazole" (Benzyl-2-chlor-4-trifluormethyl-1,3- thiazol-5-carboxylat) (S13-3), das als Saatbeiz-Safener für Hirse gegen Schäden von Alachlor und Metolachlor bekannt ist, "CL 304415" (CAS-Reg.Nr.31541-57-8) (4-Carboxy-3,4-dihydro-2H-1- benzopyran-4-essigsäure) (S13-4) der Firma American Cyanamid, das als Safener für Mais gegen Schäden von Imidazolinonen bekannt ist, "MG 191" (CAS-Reg.Nr.96420-72-3) (2-Dichlormethyl-2- 25 methyl-1,3-dioxolan) (S13-5) der Firma Nitrokemia, das als Safener für Mais bekannt ist, "MG-838" (CAS-Reg.Nr.133993-74-5) (2-propenyl 1-oxa-4-azaspiro[4.5]decan-4-carbodithioat) (S13-6) der Firma Nitrokemia, "Disulfoton" (O,O-Diethyl S-2-ethylthioethyl phosphordithioat) (S13-7), "Dietholate" (O,O-Diethyl-O-phenylphosphorothioat) (S13-8), "Mephenate" (4-Chlorphenyl- methylcarbamat) (S13-9). 30 S14) Wirkstoffe, die neben einer herbiziden Wirkung gegen Schadpflanzen auch Safenerwirkung an Kulturpflanzen wie Reis aufweisen, wie z. B. BCS241005-Ausland STR 273 "Dimepiperate" oder "MY-93" (S-1-Methyl-1-phenylethyl-piperidin-1-carbothioat), das als Safener für Reis gegen Schäden des Herbizids Molinate bekannt ist, "Daimuron" oder "SK 23" (1-(1-Methyl-1- phenylethyl)-3-p-tolyl-harnstoff), das als Safener für Reis gegen Schäden des Herbizids Imazosulfuron bekannt ist, "Cumyluron" = "JC-940" (3-(2-Chlorphenylmethyl)-1-(1-methyl-1-phenyl-ethyl)harnstoff, 5 siehe JP-A-60087254), das als Safener für Reis gegen Schäden einiger Herbizide bekannt ist, "Methoxyphenon" oder "NK 049" (3,3'-Dimethyl-4-methoxy-benzophenon), das als Safener für Reis gegen Schäden einiger Herbizide bekannt ist, "CSB" (1-Brom-4-(chlormethylsulfonyl)benzol) von Kumiai, (CAS-Reg.Nr.54091-06-4), das als Safener gegen Schäden einiger Herbizide in Reis bekannt ist. 10 S15) Verbindungen der Formel (S15) oder deren Tautomere wie sie in der WO-A-2008/131861 und WO-A-2008/131860 beschrieben sind worin RH 1 einen (C1-C6)-Haloalkylrest bedeutet und 15 RH 2 Wasserstoff oder Halogen bedeutet und RH 3, RH 4 unabhängig voneinander Wasserstoff, (C1-C16)-Alkyl, (C2-C16)-Alkenyl oder (C2-C16)-Alkinyl, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy, (C1-C4)-Alkylthio, (C1-C4)-Alkylamino, Di[(C1-C4)-alkyl]-amino, [(C1-C4)-Alkoxy]-carbonyl, [(C1-C4)Haloalkoxy]- 20 carbonyl, (C3-C6)-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, und Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, oder (C3- C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C3-C6)-Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, oder (C4-C6)Cycloalkenyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder 25 ungesättigten carbocyclischen Ring kondensiert ist, wobei jeder der letztgenannten 4 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy, (C1-C4)-Alkylthio, (C1-C4)- Alkylamino, Di[(C1-C4)-alkyl]-amino, [(C1-C4)-Alkoxy]-carbonyl, [(C1-C4)-Haloalkoxy]-carbonyl, BCS241005-Ausland STR 274 (C3-C6)-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, und Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet, oder RH 3 (C1-C4)-Alkoxy, (C2-C4)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C4)-Haloalkoxy bedeutet 5 und RH 4 Wasserstoff oder (C1-C4)-Alkyl bedeutet, oder RH 3 und RH 4 zusammen mit dem direkt gebundenen N-Atom einen vier- bis achtgliedrigen heterocyclischen Ring, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der10 unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (C1- C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy und (C1-C4)-Alkylthio substituiert ist, bedeutet. S16) Wirkstoffe, die vorrangig als Herbizide eingesetzt werden, jedoch auch Safenerwirkung auf Kulturpflanzen aufweisen, z.B. (2,4-Dichlorphenoxy)essigsäure (2,4-D), (4-Chlorphenoxy)essigsäure,15 (R,S)-2-(4-Chlor-o-tolyloxy)propionsäure (Mecoprop), 4-(2,4-Dichlorphenoxy)buttersäure (2,4-DB), (4- Chlor-o-tolyloxy)-essigsäure (MCPA), 4-(4-Chlor-o-tolyloxy)buttersäure, 4-(4-Chlorphenoxy)- buttersäure, 3,6-Dichlor-2-methoxybenzoesäure (Dicamba), 1-(Ethoxycarbonyl)ethyl-3,6-dichlor-2- methoxybenzoat (Lactidichlor-ethyl). Biologische Beispiele 20 Die folgenden Abkürzungen Schad- und Kulturpflanzen werden in den unten stehenden Tabellen und Versuchsauswertungen verwendet: Getestete Schadpflanzen: 25 ABUTH: Abutilon theophrasti AGSTE: Agrostis tenuis ALOMY: Alopecurus myosuroides AMAPA: Amaranthus palmeri AMARE Amaranthus retroflexus 30 AVEFA: Avena fatua DIGSA: Digitaria sanguinalis DIPTE: Diplotaxis tenuis BCS241005-Ausland STR 275 ECHCG: Echinochloa crus-galli KCHSC: Kochia scoparia LOLPE: Lolium perenne LOLRI: Lolium rigidum 5 MATCH: Matricaria chamomilla MATIN: Matricaria inodora PHBPU: Pharbitis purpurea POAAN: Poa annua POLCO: Polygonum convolvulus 10 SETVI: Setaria viridis STEME: Stellaria media VERPE: Veronica persica VIOTR: Viola tricolor 15 Getestete Kulturpflanzen: BRSNW: Brassica napus GLXMA: Glycine max ORYSA: Oryza sativa TRZAS: Triticum aestivum 20 ZEAMX: Zea mays A. Herbizide Wirkung im frühen Nachauflauf Samen von mono- bzw. dikotylen Unkrautpflanzen werden in 96-well Mikrotiterplatten in Quarzsand 25 ausgelegt und in der Klimakammer unter kontrollierten Wachstumsbedingungen angezogen. 5 bis 7 Tage nach der Aussaat werden die Versuchspflanzen im Keimblattstadium behandelt. Die in Form von Emulsionskonzentraten (EC) formulierten erfindungsgemäßen Verbindungen werden mit einer Wasseraufwandmenge von umgerechnet 2200 Liter pro Hektar appliziert. Nach 9 bis 12 Tagen Standzeit der Versuchspflanzen in der Klimakammer unter optimalen Wachstumsbedingungen, wird die 30 Wirkung der Präparate visuell im Vergleich zu unbehandelten Kontrollen bonitiert. Beispielsweise bedeutet 100% Wirkung = Pflanzen sind abgestorben, 0% Wirkung = wie Kontrollpflanzen. A1. Wirkung gegen AGSTE: In diesem Test hatten beispielsweise die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (80% bis 100%) bei einer Aufwandmenge von 1900 g35 Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1- 26, I.1-29, I.1-32, I.1-35, I.1-36, I.1-38, I.1-40, I.1-47, I.1-49, I.1-50, I.1-52, I.1-53, I.1-68, I.1-70, I.1- 80, I.1-93, I.1-143, I.1-145, I.2-1, I.1-152, I.1-153, I.2-5, I.2-7, I.1-155, I.1-156. I.1-157, I.1-158, I.2-8, BCS241005-Ausland STR 276 I.2-6, I.2-11, I.2-10, I.2-13, I.1-252, I.1-169, I.2-15, I.2-17, I.1-174, I.1-177, I.2-21, I.2-20, I.1-178, I.2- 36, I.2-25, I.2-32, I.2-28, I.2-27, I.2-29, I.1-185, I.3-13, I.3-17, I.1-189, I.1-190, I.1-202, I.1-203, I.1- 200, I.1-201, I.1-207, I.1-212, I.1-213, I.3-9, I.1-259, I.2-37, I.1-260, I.2-44, I.1-272, I.1-274, I.1-280, I.1-284, I.1-288, I.1-294, I.1-302, I.1-303, I.2-75, I.2-82, I.2-84, I.1-316, I.1-317, I.1-315, I.2-95, I.1- 5 355, I.1-356, I.1-334, I.1-338, I.1-348, I.1-337, I.1-347, I.1-346, I.1-336, I.1-359, I.1-362, I.1-363, I.1- 341, I.1-342, I.1-345, I.2-103, I.1-366, I.1-368, I.1-371, I.2-108, I.2-109, I.2-110, I.1-376, I.1-378, I.1- 379, I.1-380, I.1-393, I.1-394, I.1-397, I.1-398, I.1-399, I.1-400, I.1-401, I.2-120, I.1-403, I.1-405, I.1- 412, I.2-121, I.2-122, I.2-123, I.2-125, I.2-145, I.1-418, I.1-419, I.1-420, I.1-422, I.2-148, I.1-427, I.2- 156, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.2-162, I.1-435, I.1-437, I.1-438, I.2-166, I.2-167, I.2-10 170, I.1-439, I.1-440, I.1-441, I.1-442, I.2-171, I.2-172, I.2-173, I.2-177, I.1-443, I.1-445, I.2-181, I.2- 182, I.1-448, I.1-449, I.1-450, I.1-451, I.1-453, I.2-191, I.2-195, I.1-454, I.1-458, I.1-460, I.1-464, I.1- 466, I.1-470, I.1-557, I.1-556, I.1-483, I.1-484, I.1-486, I.1-487, I.1-493, I.1-494, I.1-495, I.1-496, I.1- 497, I.2-206, I.2-207, I.1-513, I.1-514, I.1-515, I.2-211, I.1-517. Die folgenden erfindungsgemäßen Verbindungen hatten weiterhin eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 15 950 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-40, I.1-47, I.1-49, I.1-50, I.1-52, I.1-53, I.1-68, I.1-70, I.1-79, I.1-80, I.1-93, I.1-145, I.1-149, I.2-1, I.1-152, I.1-153, I.2-5, I.2-7, I.1-155, I.1-157, I.1-158, I.2-8, I.2-6, I.2-11, I.2-10, I.2-13, I.1-169, I.2-15, I.2-17, I.1-174, I.1-177, I.2-21, I.2-20, I.1-178, I.2-36, I.2-25, I.2-32, I.2- 28, I.2-27, I.2-29, I.3-13, I.3-17, I.1-189, I.1-190, I.1-202, I.1-203, I.1-200, I.1-201, I.1-207, I.1-212, I.1- 20 213, I.1-214, I.1-259, I.1-260, I.1-272, I.1-274, I.1-280, I.1-294, I.2-75, I.2-82, I.2-84, I.1-316, I.1-317, I.1-315, I.2-95, I.1-355, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-359, I.1-361, I.1-362, I.1- 363, I.1-341, I.1-345, I.2-103, I.1-370, I.1-371, I.2-108, I.2-109, I.2-110, I.1-376, I.1-379, I.1-393, I.1- 394, I.1-396, I.1-398, I.1-399, I.1-400, I.1-401, I.2-120, I.1-403, I.1-412, I.2-121, I.2-122, I.2-123, I.2- 125, I.2-145, I.1-418, I.1-420, I.1-422, I.2-148, I.1-427, I.2-156, I.1-430, I.1-431, I.1-432, I.1-433, I.1-25 434, I.1-435, I.1-437, I.1-438, I.2-166, I.2-167, I.2-169, I.2-170, I.1-439, I.1-440, I.1-441, I.1-442, I.2- 171, I.2-172, I.2-173, I.2-177, I.1-443, I.1-445, I.2-181, I.2-182, I.1-448, I.1-449, I.1-450, I.1-451, I.1- 453, I.2-191, I.2-195, I.1-454, I.1-456, I.1-458, I.1-460, I.1-462, I.1-464, I.1-466, I.1-468, I.1-470, I.1- 558, I.1-557, I.1-556, I.1-487, I.1-493, I.1-494, I.1-495, I.1-496, I.1-497, I.2-206, I.1-513, I.1-514, I.1- 515, I.2-211, I.1-517. Die folgenden erfindungsgemäßen Verbindungen zeigten eine sehr gute herbizide 30 Wirkung (> 80%) bei einer Aufwandmenge von 475 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-40, I.1-47, I.1-49, I.1-50, I.1-52, I.1-53, I.1-68, I.1-70, I.1-79, I.1-80, I.1-93, I.1-143, I.1-145, I.1-149, I.2-1, I.1-152, I.1- 153, I.2-5, I.1-155, I.1-157, I.1-158, I.2-8, I.2-6, I.2-11, I.2-10, I.2-13, I.1-252, I.1-169, I.2-15, I.2-17, I.1-174, I.1-177, I.2-21, I.2-20, I.1-178, I.2-36, I.2-25, I.2-32, I.2-27, I.2-29, I.1-190, I.1-202, I.1-203,35 I.1-200, I.1-201, I.1-206, I.1-207, I.1-212, I.1-213, I.1-259, I.2-37, I.1-260, I.1-272, I.1-274, I.1-279, I.1- 280, I.1-281, I.1-290, I.2-75, I.2-82, I.2-84, I.1-316, I.1-317, I.1-315, I.2-95, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-359, I.1-362, I.1-363, I.1-341, I.1-345, I.2-103, I.1-371, I.2-108, I.2-110, BCS241005-Ausland STR 277 I.1-393, I.1-394, I.1-396, I.1-397, I.1-398, I.1-399, I.1-400, I.1-401, I.2-120, I.1-412, I.1-413, I.2-121, I.2-122, I.2-123, I.2-125, I.2-145, I.1-418, I.1-419, I.1-420, I.1-421, I.1-422, I.1-427, I.2-155, I.1-430, I.1-431, I.1-433, I.1-434, I.1-435, I.1-437, I.1-438, I.2-166, I.2-167, I.1-439, I.1-440, I.1-441, I.2-171, I.2-172, I.2-173, I.2-177, I.1-443, I.1-445, I.2-181, I.2-182, I.1-448, I.1-450, I.1-451, I.1-453, I.2-191, 5 I.2-195, I.1-454, I.1-456, I.1-458, I.1-460, I.1-462, I.1-464, I.1-466, I.1-468, I.1-470, I.1-558, I.1-557, I.1-556, I.1-478, I.1-487, I.1-493, I.1-494, I.1-495, I.1-496, I.1-497, I.2-206, I.1-513, I.1-514, I.1-515, I.2-211. Darüber hinaus zeigten die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 238 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-40, I.1-47, I.1-49,10 I.1-50, I.1-52, I.1-53, I.1-68, I.1-70, I.1-80, I.1-93, I.1-145, I.1-149, I.2-1, I.1-152, I.1-153, I.1-155, I.1- 157, I.1-158, I.2-8, I.2-11, I.2-10, I.2-13, I.1-252, I.1-169, I.1-178, I.2-36, I.2-25, I.2-32, I.2-27, I.2-29, I.1-202, I.1-203, I.1-201, I.1-206, I.1-207, I.1-212, I.1-259, I.1-260, I.1-272, I.1-274, I.1-279, I.1-280, I.1-281, I.2-75, I.2-82, I.2-84, I.1-316, I.1-315, I.2-95, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1- 346, I.1-362, I.1-341, I.1-345, I.2-103, I.1-371, I.2-108, I.2-110, I.1-393, I.1-394, I.1-396, I.1-397, I.1-15 398, I.1-400, I.1-401, I.2-120, I.1-412, I.1-413, I.2-121, I.2-122, I.2-123, I.2-125, I.2-145, I.1-418, I.1- 420, I.1-421, I.1-422, I.1-427, I.2-155, I.2-156, I.1-431, I.1-432, I.1-433, I.1-434, I.2-162, I.1-435, I.1- 437, I.1-438, I.2-167, I.1-439, I.1-440, I.1-441, I.2-171, I.2-172, I.2-173, I.2-177, I.1-443, I.1-445, I.2- 182, I.1-450, I.1-451, I.1-453, I.2-191, I.1-454, I.1-456, I.1-458, I.1-459, I.1-460, I.1-462, I.1-464, I.1- 466, I.1-468, I.1-470, I.1-557, I.1-556, I.1-487, I.1-493, I.1-494, I.1-495, I.1-496, I.1-497, I.2-206, I.1- 20 513, I.1-515, I.2-211. A2. Wirkung gegen LOLPE: In diesem Test hatten beispielsweise die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (80% bis 100%) bei einer Aufwandmenge von 1900 g Aktivsubstanz pro Hektar: I.1-12, I.1-13, I.1-14, I.1-16, I.1-18, I.1-19, I.1-21, I.1-22, I.1-26, I.1-29, I.1-25 32, I.1-35, I.1-36, I.1-38, I.1-40, I.1-49, I.1-52, I.1-53, I.1-66, I.1-68, I.1-80, I.1-93, I.1-145, I.1-146, I.2- 1, I.1-152, I.1-153, I.1-155, I.1-157, I.1-158, I.2-11, I.2-10, I.2-13, I.1-169, I.1-174, I.1-178, I.2-36, I.2- 32, I.2-27, I.2-29, I.1-198, I.1-203, I.1-260, I.1-272, I.1-274, I.1-280, I.1-285, I.2-82, I.2-84, I.1-316, I.1- 317, I.1-315, I.2-95, I.1-338, I.1-337, I.1-347, I.1-346, I.1-357, I.1-362, I.1-341, I.1-344, I.1-345, I.2- 103, I.2-104, I.1-371, I.2-108, I.2-110, I.1-379, I.1-385, I.1-390, I.1-394, I.1-395, I.1-396, I.1-401, I.2-30 123, I.2-125, I.2-145, I.1-418, I.1-420, I.1-422, I.2-156, I.1-429, I.1-430, I.1-431, I.1-432, I.1-433, I.1- 434, I.1-435, I.1-437, I.1-438, I.2-167, I.1-439, I.1-441, I.2-172, I.2-173, I.2-177, I.1-443, I.2-182, I.1- 451, I.2-191, I.2-195, I.1-454, I.1-458, I.1-460, I.1-464, I.1-466, I.1-468, I.1-470, I.1-478, I.1-490, I.1- 494, I.1-495, I.1-497, I.2-206, I.1-513, I.1-514, I.2-211, I.1-517. Die folgenden erfindungsgemäßen Verbindungen hatten weiterhin eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von35 950 g Aktivsubstanz pro Hektar: I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1- 29, I.1-223, I.1-32, I.1-35, I.1-40, I.1-49, I.1-52, I.1-53, I.1-68, I.1-80, I.1-93, I.1-145, I.1-149, I.1-152, I.1-153, I.1-155, I.2-10, I.2-13, I.1-255, I.1-169, I.1-174, I.1-178, I.2-32, I.2-27, I.2-29, I.1-203, I.1-201, BCS241005-Ausland STR 278 I.1-206, I.1-260, I.1-272, I.1-274, I.1-280, I.2-84, I.1-316, I.1-315, I.2-95, I.1-337, I.1-347, I.1-346, I.1- 357, I.1-359, I.1-340, I.1-341, I.1-345, I.2-103, I.1-371, I.2-108, I.1-379, I.1-393, I.1-394, I.1-395, I.1- 401, I.2-121, I.2-122, I.2-123, I.2-125, I.2-135, I.1-418, I.1-422, I.1-430, I.1-431, I.1-432, I.1-433, I.1- 434, I.2-162, I.1-435, I.1-437, I.1-438, I.2-166, I.2-167, I.2-169, I.1-439, I.1-441, I.2-172, I.2-173, I.2- 5 177, I.1-443, I.2-182, I.1-451, I.1-453, I.2-191, I.1-454, I.1-456, I.1-458, I.1-460, I.1-464, I.1-466, I.1- 470, I.1-556, I.1-478, I.1-487, I.1-491, I.1-495, I.1-496, I.1-513, I.2-211, I.1-517. Die folgenden erfindungsgemäßen Verbindungen zeigten eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 475 g Aktivsubstanz pro Hektar: I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-32, I.1-40, I.1-68, I.1-80, I.1-145, I.1-149, I.1-152, I.1-153, I.1-155, I.1-157, I.2-11, 10 I.2-10, I.2-13, I.1-174, I.2-32, I.2-27, I.1-260, I.1-272, I.1-274, I.1-279, I.1-280, I.2-82, I.2-84, I.1-316, I.1-315, I.2-95, I.1-334, I.1-337, I.1-347, I.1-346, I.1-357, I.1-359, I.1-341, I.1-345, I.1-371, I.2-108, I.1- 393, I.1-394, I.1-395, I.1-397, I.1-401, I.2-122, I.2-125, I.2-145, I.1-420, I.1-422, I.1-430, I.1-431, I.1- 433, I.1-434, I.1-437, I.1-438, I.1-439, I.1-441, I.2-172, I.2-177, I.1-443, I.2-182, I.1-453, I.2-191, I.1- 454, I.1-456, I.1-458, I.1-460, I.1-468, I.1-470, I.1-558, I.1-472, I.1-487, I.1-495, I.1-496, I.1-513. 15 Darüber hinaus zeigten die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 238 g Aktivsubstanz pro Hektar: I.1-12, I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-32, I.1-40, I.1-50, I.1-80, I.1-152, I.1-153, I.1-155, I.2-13, I.2- 32, I.1-272, I.1-274, I.1-280, I.2-82, I.1-347, I.1-346, I.1-359, I.1-341, I.1-345, I.1-401, I.2-122, I.2-125, I.1-422, I.1-431, I.1-433, I.1-434, I.1-437, I.1-439, I.1-441, I.2-172, I.1-443, I.2-182, I.1-451, I.1-453, 20 I.1-458, I.1-464, I.1-466, I.1-470, I.1-495, I.1-496, I.1-513. A3. Wirkung gegen POAAN: In diesem Test hatten beispielsweise die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (80% bis 100%) bei einer Aufwandmenge von 1900 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-25 29, I.1-32, I.1-35, I.1-36, I.1-40, I.1-47, I.1-49, I.1-50, I.1-52, I.1-54, I.1-66, I.1-68, I.1-70, I.1-80, I.1- 93, I.1-145, I.1-150, I.2-1, I.1-152, I.1-153, I.1-155, I.1-156, I.1-157, I.1-158, I.2-10, I.2-13, I.1-169, I.1- 174, I.1-177, I.1-178, I.2-32, I.2-27, I.2-29, I.1-202, I.1-203, I.1-200, I.1-201, I.1-212, I.1-213, I.1-259, I.1-272, I.1-274, I.1-280, I.2-82, I.1-316, I.1-317, I.1-355, I.1-356, I.1-334, I.1-337, I.1-347, I.1-346, I.1- 357, I.1-359, I.1-362, I.1-363, I.1-341, I.1-342, I.1-345, I.2-103, I.1-371, I.1-377, I.1-378, I.1-389, I.1-30 394, I.1-397, I.1-398, I.1-399, I.1-400, I.1-401, I.1-404, I.2-121, I.2-122, I.2-125, I.1-420, I.1-422, I.1- 427, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-170, I.1-439, I.1-440, I.1-441, I.1- 442, I.2-171, I.1-443, I.2-181, I.2-182, I.1-448, I.1-451, I.2-191, I.1-458, I.1-557, I.1-556, I.1-483, I.1- 484, I.1-493, I.1-494, I.1-495, I.1-496, I.1-513, I.1-515, I.2-211. Die folgenden erfindungsgemäßen Verbindungen hatten weiterhin eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 35 950 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-40, I.1-47, I.1-49, I.1-50, I.1-68, I.1-70, I.1-80, I.1-93, I.1-143, I.1-145, I.1- 150, I.2-1, I.1-152, I.1-153, I.1-155, I.1-156, I.1-157, I.1-158, I.2-10, I.2-13, I.1-169, I.1-174, I.1-177, BCS241005-Ausland STR 279 I.2-32, I.2-27, I.2-29, I.1-202, I.1-203, I.1-200, I.1-201, I.1-212, I.1-213, I.1-259, I.1-272, I.1-274, I.1- 280, I.1-281, I.2-82, I.1-316, I.1-317, I.1-356, I.1-334, I.1-337, I.1-347, I.1-346, I.1-357, I.1-362, I.1- 363, I.1-341, I.1-342, I.1-345, I.2-103, I.1-371, I.2-110, I.1-377, I.1-397, I.1-398, I.1-399, I.1-400, I.1- 401, I.2-121, I.2-122, I.2-123, I.2-125, I.1-420, I.1-422, I.1-427, I.1-430, I.1-431, I.1-432, I.1-433, I.1- 5 434, I.1-435, I.1-437, I.2-166, I.1-439, I.1-440, I.1-441, I.1-442, I.1-443, I.2-182, I.1-448, I.1-451, I.2- 191, I.1-458, I.1-470, I.1-557, I.1-556, I.1-484, I.1-493, I.1-494, I.1-495, I.1-496, I.1-513, I.1-515, I.2- 211. Die folgenden erfindungsgemäßen Verbindungen zeigten eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 475 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-36, I.1-40, I.1-47, I.1-49, I.1-50, I.1-68, I.1-70, 10 I.1-79, I.1-80, I.1-93, I.1-143, I.1-145, I.1-152, I.1-153, I.1-155, I.1-156, I.1-157, I.1-158, I.2-10, I.2-13, I.1-169, I.1-174, I.2-32, I.2-27, I.2-29, I.1-202, I.1-203, I.1-201, I.1-212, I.1-213, I.1-259, I.1-272, I.1- 274, I.1-280, I.1-281, I.2-82, I.2-84, I.1-316, I.1-317, I.1-315, I.1-334, I.1-337, I.1-347, I.1-346, I.1-362, I.1-363, I.1-341, I.1-345, I.2-103, I.1-371, I.2-110, I.1-397, I.1-398, I.1-400, I.1-401, I.2-122, I.2-123, I.2-125, I.1-420, I.1-422, I.1-427, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-166, 15 I.1-439, I.1-440, I.1-441, I.1-443, I.2-182, I.1-451, I.2-191, I.1-458, I.1-470, I.1-556, I.1-493, I.1-494, I.1-495, I.1-496, I.1-513, I.1-515, I.2-211. Darüber hinaus zeigten die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 238 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1- 32, I.1-35, I.1-36, I.1-40, I.1-47, I.1-49, I.1-50, I.1-68, I.1-70, I.1-80, I.1-143, I.1-145, I.2-1, I.1-152, I.1-20 153, I.1-155, I.1-156, I.1-157, I.1-158, I.2-10, I.2-13, I.1-174, I.2-32, I.2-27, I.2-29, I.1-203, I.1-201, I.1- 212, I.1-213, I.1-259, I.1-274, I.1-280, I.2-82, I.2-84, I.1-316, I.1-317, I.1-334, I.1-337, I.1-347, I.1-346, I.1-363, I.1-341, I.1-345, I.2-103, I.1-371, I.1-397, I.1-398, I.1-400, I.1-401, I.2-123, I.2-125, I.1-420, I.1-422, I.1-427, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.1-439, I.1-440, I.1-443, I.2-182, I.1-470, I.1-484, I.1-495, I.1-496, I.1-513, I.1-515. 25 A4. Wirkung gegen SETVI: In diesem Test hatten beispielsweise die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (80% bis 100%) bei einer Aufwandmenge von 1900 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-18, I.1-19, I.1-32, I.1-35, I.1-40, I.1-50, I.1-52, I.1- 53, I.1-66, I.1-68, I.1-80, I.1-93, I.1-145, I.1-150, I.2-1, I.1-152, I.1-153, I.2-5, I.1-155, I.1-156, I.1-157,30 I.1-158, I.1-255, I.1-174, I.1-178, I.1-179, I.2-32, I.2-27, I.2-29, I.1-190, I.1-202, I.1-200, I.1-201, I.1- 207, I.1-260, I.2-73, I.2-84, I.1-316, I.1-315, I.2-95, I.1-356, I.1-338, I.1-348, I.1-337, I.1-335, I.1-347, I.1-346, I.1-357, I.1-359, I.1-323, I.2-90, I.1-361, I.1-362, I.1-341, I.1-344, I.1-345, I.2-103, I.2-104, I.1- 371, I.2-110, I.1-376, I.1-378, I.1-379, I.1-385, I.1-387, I.1-397, I.1-400, I.1-401, I.1-412, I.2-121, I.1- 418, I.1-422, I.1-424, I.2-155, I.2-156, I.1-428, I.1-430, I.1-431, I.1-432, I.1-434, I.1-435, I.1-437, I.1-35 438, I.2-169, I.1-439, I.1-441, I.2-172, I.2-173, I.2-174, I.1-445, I.2-182, I.1-451, I.2-189, I.2-191, I.2- 195, I.1-458, I.1-460, I.1-464, I.1-470, I.1-558, I.1-557, I.1-556, I.1-487, I.1-493, I.1-494, I.1-495, I.1- 496, I.1-497, I.2-206, I.1-508, I.1-513, I.1-514, I.1-515, I.1-516, I.2-211, I.1-517, I.1-518. Die folgenden BCS241005-Ausland STR 280 erfindungsgemäßen Verbindungen hatten weiterhin eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 950 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-18, I.1-19, I.1-32, I.1-35, I.1-40, I.1-50, I.1-52, I.1-66, I.1-68, I.1-70, I.1-80, I.1-93, I.1-145, I.1-149, I.1-150, I.2-1, I.1-152, I.1- 153, I.1-157, I.2-10, I.2-13, I.1-174, I.1-177, I.1-178, I.2-32, I.2-27, I.2-29, I.1-202, I.1-201, I.1-207, I.1- 5 260, I.1-271, I.1-272, I.2-75, I.2-84, I.1-308, I.1-316, I.1-315, I.1-355, I.1-356, I.1-338, I.1-348, I.1-337, I.1-347, I.1-346, I.1-359, I.1-362, I.1-341, I.1-345, I.2-103, I.1-371, I.2-110, I.1-376, I.1-385, I.1-397, I.1-400, I.1-412, I.2-122, I.2-123, I.2-125, I.1-418, I.1-422, I.2-155, I.2-156, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-167, I.2-169, I.1-439, I.1-441, I.2-172, I.2-173, I.2-177, I.1-445, I.2-182, I.1-451, I.2-191, I.2-195, I.1-454, I.1-456, I.1-458, I.1-464, I.1-466, I.1-468, I.1-470, I.1-558, 10 I.1-557, I.1-556, I.1-472, I.1-487, I.1-494, I.1-495, I.1-496, I.1-497, I.2-206, I.1-513, I.1-515, I.2-211, I.1-517. Die folgenden erfindungsgemäßen Verbindungen zeigten eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 475 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-18, I.1-26, I.1-32, I.1-35, I.1-40, I.1-49, I.1-50, I.1-52, I.1-68, I.1-70, I.1-80, I.1-93, I.1-145, I.1-152, I.1-153, I.1- 155, I.2-10, I.1-174, I.1-177, I.1-178, I.2-27, I.2-29, I.1-201, I.1-207, I.1-280, I.2-82, I.2-84, I.1-316, I.1-15 356, I.1-338, I.1-348, I.1-337, I.1-347, I.1-346, I.1-345, I.2-103, I.1-371, I.1-412, I.2-122, I.2-123, I.2- 125, I.1-418, I.1-422, I.2-156, I.1-431, I.1-433, I.1-434, I.1-437, I.2-167, I.1-439, I.1-441, I.1-445, I.2- 182, I.1-451, I.1-458, I.1-464, I.1-558, I.1-557, I.1-556, I.1-495, I.1-496, I.1-497, I.1-512, I.1-513. Darüber hinaus zeigten die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 238 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14,20 I.1-18, I.1-35, I.1-40, I.1-50, I.1-68, I.1-70, I.1-80, I.1-93, I.1-145, I.2-1, I.1-152, I.1-153, I.2-10, I.1- 174, I.1-178, I.2-29, I.2-41, I.2-82, I.2-84, I.1-316, I.1-338, I.1-348, I.1-337, I.1-347, I.1-346, I.1-345, I.1-371, I.2-123, I.2-125, I.1-418, I.1-431, I.1-433, I.1-434, I.1-435, I.1-437, I.2-167, I.1-439, I.1-441, I.2-182, I.1-458, I.1-464, I.1-470, I.1-558, I.1-557, I.1-556, I.1-495, I.1-496, I.1-497, I.1-513. 25 A5. Wirkung gegen DIPTE: In diesem Test hatten beispielsweise die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (80% bis 100%) bei einer Aufwandmenge von 1900 g Aktivsubstanz pro Hektar: I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-40, I.1-47, I.1- 49, I.1-50, I.1-52, I.1-108, I.1-152, I.1-153, I.2-7, I.1-155, I.1-156, I.2-6, I.2-10, I.2-13, I.2-15, I.1-177, I.2-32, I.2-27, I.2-29, I.1-202, I.1-203, I.1-206, I.1-210, I.1-212, I.1-213, I.3-13, I.1-259, I.1-270, I.2-43, 30 I.1-291, I.1-294, I.2-60, I.2-64, I.2-66, I.2-72, I.2-82, I.2-84, I.1-316, I.1-355, I.1-334, I.1-348, I.1-322, I.1-337, I.1-347, I.1-346, I.1-336, I.1-325, I.1-328, I.1-323, I.2-90, I.1-361, I.1-362, I.1-340, I.1-341, I.1- 345, I.2-103, I.2-104, I.2-108, I.2-109, I.1-378, I.1-379, I.2-111, I.1-389, I.1-393, I.1-394, I.1-396, I.1- 397, I.1-398, I.1-399, I.1-400, I.1-401, I.2-121, I.2-122, I.2-123, I.2-125, I.1-418, I.1-419, I.1-420, I.2- 156, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.1-438, I.2-167, I.2-169, I.2-170, I.2-173, I.2-35 174, I.2-176, I.1-443, I.1-445, I.2-182, I.1-448, I.1-450, I.1-451, I.2-187, I.2-189, I.2-191, I.1-470, I.1- 558, I.1-557, I.1-556, I.1-483, I.1-484, I.1-492, I.1-493, I.1-495, I.1-496, I.1-508, I.1-511, I.1-512, I.1- 513, I.1-515, I.1-517. Die folgenden erfindungsgemäßen Verbindungen hatten weiterhin eine sehr gute BCS241005-Ausland STR 281 herbizide Wirkung (> 80%) bei einer Aufwandmenge von 950 g Aktivsubstanz pro Hektar: I.1-14, I.1- 16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-40, I.1-47, I.1-49, I.1-50, I.1-153, I.2-7, I.1-155, I.2- 10, I.2-27, I.1-203, I.1-210, I.1-212, I.1-213, I.3-13, I.1-291, I.1-294, I.2-66, I.2-82, I.2-84, I.1-316, I.1- 334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-336, I.1-325, I.1-323, I.1-361, I.1-362, I.1-340, I.1-341, I.1- 5 345, I.2-103, I.2-104, I.2-108, I.1-394, I.1-397, I.1-401, I.2-122, I.2-123, I.2-125, I.1-420, I.2-156, I.1- 431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.1-438, I.2-165, I.2-167, I.2-170, I.2-176, I.1-443, I.2- 181, I.2-182, I.1-451, I.2-187, I.1-470, I.1-558, I.1-557, I.1-556, I.1-495, I.1-508, I.1-512, I.1-513, I.1- 515. Die folgenden erfindungsgemäßen Verbindungen zeigten eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 475 g Aktivsubstanz pro Hektar: I.1-14, I.1-16, I.1-18, I.1-20, I.1-10 21, I.1-22, I.1-40, I.1-50, I.1-145, I.1-155, I.2-27, I.1-203, I.1-212, I.1-294, I.2-82, I.2-84, I.1-334, I.1- 348, I.1-337, I.1-347, I.1-346, I.1-323, I.1-329, I.1-362, I.1-340, I.1-345, I.2-103, I.2-104, I.1-404, I.2- 122, I.2-123, I.2-125, I.1-418, I.1-419, I.2-156, I.1-431, I.1-433, I.1-434, I.1-437, I.1-438, I.1-443, I.2- 181, I.2-182, I.1-451, I.1-558, I.1-557, I.1-556, I.1-495, I.1-513. Darüber hinaus zeigten die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge15 von 238 g Aktivsubstanz pro Hektar: I.1-14, I.1-16, I.1-20, I.1-21, I.1-22, I.1-50, I.1-155, I.1-203, I.2- 82, I.1-348, I.1-347, I.1-346, I.2-103, I.2-122, I.2-123, I.2-125, I.1-418, I.1-433, I.1-434, I.1-437, I.1- 443, I.2-182, I.1-556. A6. Wirkung gegen MATCH: In diesem Test hatten beispielsweise die folgenden erfindungsgemäßen 20 Verbindungen eine sehr gute herbizide Wirkung (80% bis 100%) bei einer Aufwandmenge von 1900 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1- 293, I.1-218, I.1-223, I.1-36, I.1-38, I.1-40, I.1-48, I.1-50, I.1-53, I.1-66, I.1-68, I.1-70, I.1-80, I.1-95, I.2-1, I.1-152, I.1-153, I.1-156, I.1-157, I.1-158, I.2-6, I.2-13, I.2-15, I.2-17, I.1-177, I.2-21, I.2-25, I.2- 27, I.2-29, I.1-185, I.1-192, I.1-195, I.1-203, I.1-200, I.1-201, I.1-206, I.1-212, I.1-213, I.3-14, I.3-10,25 I.1-258, I.1-259, I.2-37, I.1-260, I.1-264, I.1-270, I.2-41, I.1-272, I.1-274, I.1-281, I.1-284, I.1-285, I.1- 287, I.1-291, I.1-294, I.2-70, I.2-73, I.2-82, I.1-315, I.2-95, I.2-99, I.1-355, I.1-356, I.1-334, I.1-338, I.1- 348, I.1-337, I.1-335, I.1-347, I.1-346, I.1-326, I.1-359, I.1-323, I.2-93, I.2-90, I.1-361, I.1-362, I.1-363, I.1-339, I.1-340, I.1-341, I.1-342, I.1-343, I.1-345, I.2-103, I.1-368, I.1-369, I.1-370, I.1-371, I.2-107, I.2-108, I.2-110, I.1-374, I.1-376, I.1-377, I.1-378, I.1-380, I.1-381, I.2-113, I.1-389, I.1-393, I.1-394, 30 I.1-396, I.1-397, I.1-398, I.1-399, I.1-400, I.1-401, I.2-117, I.1-404, I.1-405, I.1-407, I.1-412, I.1-413, I.2-121, I.2-122, I.2-123, I.2-124, I.2-125, I.2-127, I.2-135, I.2-137, I.2-138, I.2-141, I.2-145, I.1-418, I.1-419, I.1-420, I.1-421, I.1-422, I.1-427, I.2-155, I.2-156, I.1-428, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.2-162, I.1-435, I.1-436, I.1-437, I.1-438, I.2-167, I.2-168, I.2-169, I.2-170, I.1-439, I.1-441, I.2-171, I.2-173, I.2-176, I.2-177, I.1-443, I.1-445, I.2-181, I.2-182, I.1-446, I.2-184, I.1-448, I.1-449, 35 I.1-450, I.1-451, I.2-187, I.2-189, I.1-453, I.2-191, I.1-454, I.1-456, I.1-458, I.1-459, I.1-460, I.1-464, I.1-466, I.1-471, I.1-558, I.1-557, I.1-556, I.1-472, I.1-478, I.1-483, I.1-484, I.1-485, I.1-486, I.1-493, I.1-494, I.1-495, I.1-496, I.1-497, I.2-206, I.2-207, I.2-209, I.1-504, I.1-508, I.1-510, I.1-513, I.1-515, BCS241005-Ausland STR 282 I.1-516, I.2-211, I.1-517. Die folgenden erfindungsgemäßen Verbindungen hatten weiterhin eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 950 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-38, I.1-40, I.1-50, I.1-53, I.1-68, I.1-80, I.1-142, I.1-145, I.1-150, I.2-1, I.1-152, I.1-153, I.1-156, I.1-157, I.1-158, I.2-6, I.2-13, I.1-177, 5 I.2-25, I.2-27, I.2-29, I.1-196, I.1-202, I.1-203, I.1-200, I.1-201, I.1-212, I.1-213, I.3-14, I.3-13, I.1-259, I.2-37, I.1-264, I.1-270, I.2-43, I.2-41, I.1-272, I.1-274, I.1-291, I.2-73, I.2-75, I.2-82, I.1-308, I.2-95, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-326, I.1-359, I.1-323, I.2-93, I.2-90, I.1-361, I.1- 362, I.1-363, I.1-341, I.1-342, I.1-345, I.2-103, I.2-104, I.1-371, I.2-109, I.1-376, I.1-395, I.1-396, I.1- 397, I.1-398, I.1-399, I.1-400, I.1-401, I.1-412, I.1-413, I.2-121, I.2-122, I.2-123, I.2-125, I.2-138, I.2-10 141, I.1-418, I.1-420, I.1-422, I.1-427, I.2-155, I.2-156, I.1-428, I.1-430, I.1-431, I.1-432, I.1-433, I.1- 434, I.1-435, I.1-436, I.1-437, I.1-438, I.2-167, I.2-168, I.2-169, I.2-170, I.1-441, I.2-172, I.2-173, I.2- 176, I.1-443, I.1-445, I.2-181, I.2-182, I.1-448, I.1-449, I.1-450, I.1-451, I.1-453, I.2-191, I.1-454, I.1- 458, I.1-459, I.1-460, I.1-462, I.1-464, I.1-466, I.1-471, I.1-558, I.1-557, I.1-556, I.1-472, I.1-478, I.1- 483, I.1-484, I.1-485, I.1-487, I.1-493, I.1-494, I.1-495, I.1-496, I.1-497, I.1-508, I.1-513, I.1-515, I.1- 15 517. Die folgenden erfindungsgemäßen Verbindungen zeigten eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 475 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-35, I.1-38, I.1-40, I.1-47, I.1-50, I.1-53, I.1-68, I.1-145, I.1-150, I.1- 155, I.2-13, I.2-25, I.2-27, I.2-29, I.1-196, I.1-200, I.1-201, I.1-206, I.1-210, I.1-212, I.1-213, I.1-259, I.2-37, I.1-270, I.1-272, I.1-274, I.2-75, I.2-82, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-20 359, I.1-323, I.1-361, I.1-363, I.1-339, I.1-345, I.2-103, I.1-371, I.1-397, I.1-398, I.1-400, I.1-401, I.1- 412, I.2-121, I.2-123, I.2-125, I.1-420, I.1-422, I.2-156, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.1- 435, I.1-437, I.2-167, I.2-169, I.2-170, I.1-443, I.2-181, I.1-448, I.1-449, I.1-453, I.2-191, I.1-454, I.1- 458, I.1-459, I.1-460, I.1-464, I.1-466, I.1-470, I.1-558, I.1-557, I.1-556, I.1-483, I.1-484, I.1-485, I.1- 494, I.1-495, I.1-496, I.1-497, I.1-513, I.1-515, I.1-517. Darüber hinaus zeigten die folgenden 25 erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 238 g Aktivsubstanz pro Hektar: I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-38, I.1-50, I.1-152, I.1-155, I.2-29, I.1-203, I.1-201, I.1-212, I.1-213, I.2-82, I.1-334, I.1-338, I.1-348, I.1-347, I.1-346, I.1- 323, I.1-361, I.1-363, I.1-345, I.2-109, I.1-397, I.1-400, I.1-401, I.2-125, I.1-420, I.2-156, I.1-432, I.1- 433, I.1-434, I.1-435, I.1-436, I.1-437, I.1-438, I.2-167, I.2-170, I.1-445, I.1-448, I.1-449, I.2-191, I.1- 30 464, I.1-466, I.1-470, I.1-558, I.1-557, I.1-556, I.1-484, I.1-495, I.1-496, I.1-513, I.1-515. A7. Wirkung gegen STEME: In diesem Test hatten beispielsweise die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (80% bis 100%) bei einer Aufwandmenge von 1900 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-14, I.1-16, I.1-20, I.1-21, I.1-22, I.1-70, I.1-80, I.1-84, I.1-35 93, I.2-5, I.2-7, I.1-156, I.2-32, I.2-27, I.3-14, I.2-38, I.2-40, I.2-37, I.2-41, I.2-60, I.2-82, I.2-85, I.1- 316, I.1-319, I.1-348, I.1-337, I.1-347, I.1-346, I.1-357, I.1-358, I.1-359, I.2-91, I.1-341, I.2-104, I.1- 377, I.1-378, I.1-398, I.1-401, I.1-420, I.1-422, I.2-156, I.1-433, I.1-434, I.1-437, I.2-170, I.1-441, I.2- BCS241005-Ausland STR 283 174, I.2-182, I.2-191, I.1-458, I.1-470, I.1-557, I.1-556, I.1-495, I.2-209, I.2-211. Die folgenden erfindungsgemäßen Verbindungen hatten weiterhin eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 950 g Aktivsubstanz pro Hektar: I.1-16, I.1-18, I.1-22, I.1-29, I.1-40, I.1-49, I.1-50, I.1-80, I.1-93, I.2-7, I.1-177, I.2-32, I.2-27, I.1-184, I.3-14, I.1-260, I.1-316, I.1-348, I.1-337, I.1-347, 5 I.1-346, I.1-339, I.1-341, I.2-104, I.1-398, I.1-401, I.2-156, I.2-177, I.2-182, I.2-191, I.1-454, I.1-557, I.2-209, I.1-515. Die folgenden erfindungsgemäßen Verbindungen zeigten eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 475 g Aktivsubstanz pro Hektar: I.1-21, I.1-93, I.1-177, I.2-32, I.2-27, I.1-316, I.1-348, I.1-347, I.1-346, I.1-401, I.2-156, I.1-437, I.2-182, I.2-191, I.1-513. Darüber hinaus zeigten die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide 10 Wirkung (> 80%) bei einer Aufwandmenge von 238 g Aktivsubstanz pro Hektar: I.1-16, I.1-21, I.1-50, I.1-348, I.1-347, I.2-156, I.2-182, I.1-495. A8. Wirkung gegen VERPE: In diesem Test hatten beispielsweise die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (80% bis 100%) bei einer Aufwandmenge von 1900 g 15 Aktivsubstanz pro Hektar: I.1-6, I.1-9, I.1-12, I.1-14, I.1-16, I.1-21, I.1-22, I.1-47, I.1-66, I.1-68, I.1-80, I.1-86, I.1-93, I.1-145, I.1-149, I.1-152, I.2-7, I.1-155, I.1-156, I.1-157, I.1-158, I.1-255, I.1-169, I.1- 177, I.2-20, I.1-178, I.2-25, I.2-32, I.2-27, I.2-29, I.3-13, I.1-203, I.1-200, I.1-201, I.1-207, I.1-212, I.1- 213, I.3-10, I.3-13, I.1-259, I.2-41, I.1-272, I.1-291, I.1-294, I.2-72, I.2-83, I.2-84, I.1-309, I.1-316, I.1- 356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-336, I.1-324, I.1-323, I.2-93, I.2-90, I.1-361, I.1-362, 20 I.1-340, I.1-341, I.1-345, I.2-104, I.1-371, I.2-108, I.2-110, I.1-376, I.1-379, I.1-383, I.1-385, I.2-113, I.1-389, I.1-394, I.1-397, I.1-399, I.1-400, I.1-401, I.2-121, I.2-123, I.2-125, I.2-132, I.2-137, I.1-418, I.1-419, I.1-420, I.1-422, I.1-427, I.2-156, I.1-428, I.1-430, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.1-438, I.2-169, I.2-170, I.1-439, I.1-441, I.2-173, I.2-174, I.2-176, I.2-177, I.1-443, I.2-181, I.2-182, I.1-446, I.1-448, I.1-449, I.1-450, I.1-451, I.2-186, I.2-192, I.1-458, I.1-464, I.1-558, I.1-557, I.1-556, 25 I.1-478, I.1-483, I.1-484, I.1-491, I.1-494, I.1-495, I.1-513, I.2-211, I.1-517. Die folgenden erfindungsgemäßen Verbindungen hatten weiterhin eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 950 g Aktivsubstanz pro Hektar: I.1-6, I.1-9, I.1-12, I.1-14, I.1-16, I.1-17, I.1-21, I.1-47, I.1-68, I.1-80, I.1-93, I.1-145, I.1-153, I.1-155, I.1-157, I.1-158, I.2-10, I.2-13, I.1-255, I.1-169, I.1-177, I.2-20, I.2-25, I.2-27, I.2-29, I.1-203, I.1-212, I.1-213, I.1-259, I.2-47, I.1-272, I.2-79, I.2-84,30 I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-324, I.1-359, I.1-323, I.2-90, I.1-361, I.1-340, I.1- 341, I.1-345, I.2-104, I.1-371, I.2-108, I.1-400, I.2-121, I.2-123, I.2-125, I.1-418, I.1-422, I.2-156, I.1- 431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-167, I.2-169, I.2-170, I.1-439, I.2-173, I.2-174, I.2- 176, I.1-443, I.1-445, I.2-181, I.2-182, I.1-448, I.1-450, I.1-451, I.2-185, I.1-454, I.1-458, I.1-463, I.1- 558, I.1-557, I.1-556, I.1-484, I.1-513. Die folgenden erfindungsgemäßen Verbindungen zeigten eine 35 sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 475 g Aktivsubstanz pro Hektar: I.1-6, I.1-12, I.1-21, I.1-93, I.1-145, I.1-153, I.1-155, I.1-157, I.1-158, I.2-13, I.1-177, I.2-25, I.2-27, I.2- 29, I.1-203, I.1-212, I.1-213, I.2-82, I.2-84, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-361, BCS241005-Ausland STR 284 I.1-341, I.1-345, I.1-371, I.2-108, I.1-400, I.1-422, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-169, I.1-439, I.2-176, I.1-443, I.2-181, I.2-182, I.1-448, I.1-451, I.1-454, I.1-458, I.1-558, I.1-557, I.1-556, I.1-495, I.1-513. Darüber hinaus zeigten die folgenden erfindungsgemäßen Verbindungen eine sehr gute herbizide Wirkung (> 80%) bei einer Aufwandmenge von 238 g Aktivsubstanz pro Hektar: I.1-12, I.1- 5 21, I.1-93, I.1-155, I.1-157, I.1-177, I.1-203, I.1-212, I.1-348, I.1-337, I.1-347, I.1-346, I.1-341, I.1-345, I.1-400, I.2-123, I.1-422, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-169, I.2-181, I.2-182, I.1-448, I.1-451, I.2-191, I.1-458, I.1-558, I.1-557, I.1-556, I.1-495, I.1-513. Wie die oben aufgeführten Ergebnisse zeigen, weisen erfindungsgemäße Verbindungen bei Behandlung 10 im frühen Nachauflauf eine gute herbizide Wirksamkeit gegen Schadpflanzen auf. Beispielsweise haben dabei die Verbindungen Nr. I.1-12, I.1-16, I.1-21, I.2-1, I.2-27, I.2-29 im oben beschriebenen Nachauflaufverfahren eine sehr gute herbizide Wirkung (80% bis 100% herbizide Wirkung) gegen Schadpflanzen wie Agrostis tenuis, Diplotaxis muralis, Diplotaxis tenuis, Lolium perenne, Matricaria chamomilla, Poa annua, Setaria viridis, Stellaria media und Veronica persica bei Aufwandmengen von 15 1900 / 950 / 475 / 238 g Aktivsubstanz pro Hektar. B. Herbizide Wirkung im Vorauflauf – Teil I Samen von mono- und dikotylen Unkrautpflanzen werden in Kunststofftöpfen, in sandigem Lehmboden, 20 ausgelegt (Doppelaussaaten mit jeweils eine Spezies mono- bzw. dikotyler Unkrautpflanzen pro Topf) und mit Erde abgedeckt. Die in Form von benetzbaren Pulvern (WP) oder als Emulsionskonzentrate (EC) formulierten erfindungsgemäßen Verbindungen werden dann als wässrige Suspension bzw. Emulsion, unter Zusatz von 0,5% Additiv, mit einer Wasseraufwandmenge von umgerechnet 600 Liter pro Hektar auf die Oberfläche der Abdeckerde appliziert. Nach der Behandlung werden die Töpfe im Gewächshaus 25 aufgestellt und unter guten Wachstumsbedingungen für die Testpflanzen gehalten. Nach ca. 3 Wochen wird die Wirkung der Präparate visuell im Vergleich zu unbehandelten Kontrollen in Prozentwerten bonitiert. Beispielsweise bedeutet 100% Wirkung = Pflanzen sind abgestorben, 0% Wirkung = wie Kontrollpflanzen. 30 In den nachstehenden Tabellen B1 bis B12 sind die Wirkungen ausgewählter Verbindungen der allgemeinen Formel (I) gemäß der Tabellen I.1 bis I.3 auf verschiedene Schadpflanzen und einer Aufwandmenge entsprechend 1280 g/ha und niedriger, die gemäß zuvor genannter Versuchsvorschrift erhalten wurden, dargestellt. 35 BCS241005-Ausland STR 285 Tabelle B1: Vorauflaufwirkung bei einer Aufwandmenge von1280 g/ha gegen ABUTH in % Tabelle B2: Vorauflaufwirkung bei einer Aufwandmenge von 1280 oder 320 g/ha gegen ALOMY in % 5 Tabelle B3a: Vorauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen DIGSA in % Tabelle B3b: Vorauflaufwirkung bei einer Aufwandmenge von 320g/ha gegen DIGSA in % BCS241005-Ausland STR 286 Tabelle B3c: Vorauflaufwirkung bei einer Aufwandmenge von 80g/ha gegen DIGSA in % Tabelle B4a: Vorauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen ECHCG in % 5 Tabelle B4b: Vorauflaufwirkung bei einer Aufwandmenge von 320g/ha gegen ECHCG in % Tabelle B5a: Vorauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen LOLRI in % Tabelle B5b: Vorauflaufwirkung bei einer Aufwandmenge von 320g/ha gegen LOLRI in % BCS241005-Ausland STR 287 Tabelle B5c: Vorauflaufwirkung bei einer Aufwandmenge von 80g/ha gegen LOLRI in % Tabelle B6a: Vorauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen MATIN in % 5 Tabelle B6b: Vorauflaufwirkung bei einer Aufwandmenge von 320g/ha gegen MATIN in % BCS241005-Ausland STR 288 Tabelle B6c: Vorauflaufwirkung bei einer Aufwandmenge von 80g/ha gegen MATIN in % Tabelle B7a: Vorauflaufwirkung bei einer Aufwandmenge von 1280g/ha and gegen POAAN in % 5 Tabelle B7b: Vorauflaufwirkung bei einer Aufwandmenge von 320g/ha gegen POAAN in % Tabelle B7c: Vorauflaufwirkung bei einer Aufwandmenge von 80g/ha gegen POAAN in % BCS241005-Ausland STR 289 Tabelle B8a: Vorauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen SETVI in % Tabelle B8b: Vorauflaufwirkung bei einer Aufwandmenge von 320g/ha gegen SETVI in % 5 Tabelle B8c: Vorauflaufwirkung bei einer Aufwandmenge von 80g/ha gegen SETVI in % Tabelle B9a: Vorauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen STEME in % BCS241005-Ausland STR 290 Tabelle B9b: Vorauflaufwirkung bei einer Aufwandmenge von 320g/ha gegen STEME in % Tabelle B10: Vorauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen AMARE in % 5 Tabelle B11a: Vorauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen VERPE in % Tabelle B11b: Vorauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen VERPE in % BCS241005-Ausland STR 291 Tabelle B12a: Vorauflaufwirkung bei einer Aufwandmenge von 1280g/ha und 320 g/ha gegen KCHSC in % Wie die Ergebnisse zeigen, weisen erfindungsgemäße Verbindungen, wie beispielsweise die 5 Verbindungen Nr. I.1-6, I.1-21, I.1-29 und andere Verbindungen aus den Tabellen B1-B12, bei Behandlung im Vorauflauf eine gute herbizide Wirksamkeit gegen Schadpflanzen auf. Beispielsweise haben dabei die Verbindungen Nr. I.1-6, I.1-21, I.1-29 im Auflaufverfahren eine sehr gute herbizide Wirkung (80% bis 100% herbizide Wirkung) gegen Schadpflanzen wie Abutilon theophrasti, Amaranthus retroflexus, Echinochloa crus-galli, Matricaria inodora, Poa annua, Setaria viridis und 10 Stellaria media bei einer Aufwandmenge von 1.28 kg/ha. C. Herbizide Wirkung im Nachauflauf – Teil I Samen von mono- bzw. dikotylen Unkrautpflanzen werden in Kunststofftöpfen in sandigem Lehmboden 15 ausgelegt (Doppelaussaaten mit jeweils einer Spezies mono- bzw. dikotyler Unkrautpflanzen pro Topf), mit Erde abgedeckt und im Gewächshaus unter kontrollierten Wachstumsbedingungen angezogen. 2 bis 3 Wochen nach der Aussaat werden die Versuchspflanzen im Einblattstadium behandelt. Die in Form von benetzbaren Pulvern (WP) oder als Emulsionskonzentrate (EC) formulierten erfindungsgemäßen Verbindungen werden als wässrige Suspension bzw. Emulsion, unter Zusatz von 0,5% Additiv, mit einer 20 Wasseraufwandmenge von umgerechnet 600 Liter pro Hektar, auf die grünen Pflanzenteile appliziert. Nach ca. 3 Wochen Standzeit der Versuchspflanzen im Gewächshaus, unter optimalen Wachstumsbedingungen, wird die Wirkung der Präparate visuell im Vergleich zu unbehandelten Kontrollen bonitiert. Beispielsweise bedeutet 100% Wirkung = Pflanzen sind abgestorben, 0% Wirkung = wie Kontrollpflanzen. 25 In den nachstehenden Tabellen C1 bis C12 sind die Wirkungen ausgewählter Verbindungen der allgemeinen Formel (I) gemäß der Tabellen I.1 bis I.3 auf verschiedene Schadpflanzen und einer Aufwandmenge entsprechend 1280 g/ha und niedriger, die gemäß zuvor genannter Versuchsvorschrift erhalten wurden, dargestellt. 30 BCS241005-Ausland STR 292 Tabelle C1: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen ABUTH in % Tabelle C2: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen ALOMY in % 5 Tabelle C3a: Nachauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen DIGSA in % Tabelle C3b: Nachauflaufwirkung bei einer Aufwandmenge von 320g/ha gegen DIGSA in % Tabelle C4a: Nachauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen ECHCG in % 10 BCS241005-Ausland STR 293 Tabelle C4b: Nachauflaufwirkung bei einer Aufwandmenge von 320g/ha gegen ECHCG in % Tabelle C5a: Nachauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen LOLRI in % 5 Tabelle C5b: Nachauflaufwirkung bei einer Aufwandmenge von 320g/ha gegen LOLRI in % Tabelle C6a: Nachauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen MATIN in % Tabelle C6b: Nachauflaufwirkung bei einer Aufwandmenge von 320g/ha gegen MATIN in % 10 Tabelle C7a: Nachauflaufwirkung bei einer Aufwandmenge von 1280g/ha and gegen POAAN in % BCS241005-Ausland STR 294 Tabelle C7b: Nachauflaufwirkung bei einer Aufwandmenge von 320g/ha gegen POAAN in % Tabelle C7c: Nachauflaufwirkung bei einer Aufwandmenge von 80g/ha gegen POAAN in % 5 Tabelle C8a: Nachauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen SETVI in % BCS241005-Ausland STR 295 Tabelle C8b: Nachauflaufwirkung bei einer Aufwandmenge von 320g/ha gegen SETVI in % Tabelle C9: Nachauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen STEME in % 5 Tabelle C10: Nachauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen AMARE in % Tabelle C11a: Nachauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen VERPE in % Tabelle C11b: Nachauflaufwirkung bei einer Aufwandmenge von 1280g/ha gegen VERPE in % 10 BCS241005-Ausland STR 296 Tabelle C12: Nachauflaufwirkung bei einer Aufwandmenge von 1280g/ha und 320 g/ha gegen KCHSC in % Wie die Ergebnisse zeigen, weisen erfindungsgemäße Verbindungen, wie beispielsweise die 5 Verbindungen Nr. I.1-6, I.1-21, I.1-22, I.1-29 und andere Verbindungen aus den Tabellen I.1 bis I.3, bei Behandlung im Nachauflauf eine gute herbizide Wirksamkeit gegen Schadpflanzen auf. Beispielsweise haben dabei die Verbindungen Nr. I.1-6, I.1-21, I.1-22, I.1-29 im Nachauflaufverfahren eine sehr gute herbizide Wirkung (80% bis 100% herbizide Wirkung) gegen Schadpflanzen wie Abutilon theophrasti, Amaranthus retroflexus, Matricaria inodora, Poa annua und Stellaria media bei einer Aufwandmenge von 10 1.28 kg Aktivsubstanz oder weniger pro Hektar. D. Herbizide Wirkung im Vorauflauf – Teil II 15 Samen von mono- bzw. dikotylen Unkrautpflanzen wurden in Kunststoff- oder organischen Pflanztöpfen ausgelegt und mit Erde abgedeckt. Die in Form von benetzbaren Pulvern (WP) oder als Emulsionskonzentrate (EC) formulierten erfindungsgemäßen Verbindungen wurden dann als wässrige Suspension bzw. Emulsion unter Zusatz von 0,5% Additiv mit einer Wasseraufwandmenge von umgerechnet 600 l/ha auf die Oberfläche der Abdeckerde appliziert. Nach der Behandlung wurden die 20 Töpfe im Gewächshaus aufgestellt und unter guten Wachstumsbedingungen für die Testpflanzen gehalten. Nach ca.3 Wochen wurde die Wirkung der Präparate visuell im Vergleich zu unbehandelten Kontrollen in Prozentwerten bonitiert. Beispielsweise bedeutet 100% Wirkung = Pflanzen sind abgestorben, 0% Wirkung = wie Kontrollpflanzen. 25 In den nachstehenden Tabellen D1 bis D15 sind die Wirkungen ausgewählter Verbindungen der allgemeinen Formel (I) gemäß den Tabellen I.1 bis I.3 auf verschiedene Schad- und Kulturpflanzen und einer Aufwandmenge entsprechend 1280 g/ha oder niedriger, die gemäß zuvor genannter Versuchsvorschrift erhalten wurden, dargestellt. 30 BCS241005-Ausland STR 297 Tabelle D1a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen ABUTH in % Tabelle D1b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen ABUTH in % 5 Tabelle D2a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen ALOMY in % BCS241005-Ausland STR 298 Tabelle D2b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen ALOMY in % Tabelle D2c: Vorauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen ALOMY in % BCS241005-Ausland STR 299 Tabelle D3a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen AMARE in % Tabelle D3b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen AMARE in % BCS241005-Ausland STR 300 Tabelle D3c: Vorauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen AMARE in % Tabelle D4a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen AVEFA in % 5 Tabelle D4b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen AVEFA in % BCS241005-Ausland STR 301 Tabelle D5a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen DIGSA in % Tabelle D5b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen DIGSA in % BCS241005-Ausland STR 302 Tabelle D5c: Vorauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen DIGSA in % Tabelle D6a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen ECHCG in % BCS241005-Ausland STR 303 Tabelle D6b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen ECHCG in % Tabelle D6c: Vorauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen ECHCG in % 5 Tabelle D7a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen LOLRI in % BCS241005-Ausland STR 304 Tabelle D7b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen LOLRI in % BCS241005-Ausland STR 305 Tabelle D7c: Vorauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen LOLRI in % Tabelle D8a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen MATIN in % BCS241005-Ausland STR 306 Tabelle D8b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen MATIN in % BCS241005-Ausland STR 307 Tabelle D8c: Vorauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen MATIN in % BCS241005-Ausland STR 308 Tabelle D9a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen PHBPU in % Tabelle D9b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen PHBPU in % 5 Tabelle D10a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen POLCO in % BCS241005-Ausland STR 309 Tabelle D10b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen POLCO in % Tabelle D10c: Vorauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen POLCO in % 5 Tabelle D11a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen SETVI in % BCS241005-Ausland STR 310 Tabelle D11b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen SETVI in % Tabelle D11c: Vorauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen SETVI in % BCS241005-Ausland STR 311 Tabelle D12a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen VERPE in % Tabelle D12b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen VERPE in % BCS241005-Ausland STR 312 Tabelle D12c: Vorauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen VERPE in % Tabelle D13a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen VIOTR in % BCS241005-Ausland STR 313 Tabelle D13b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen VIOTR in % BCS241005-Ausland STR 314 Tabelle D13c: Vorauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen VIOTR in % Tabelle D14a: Vorauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen KCHSC in % BCS241005-Ausland STR 315 Tabelle D14b: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen KCHSC in % Tabelle D14c: Vorauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen KCHSC in % 5 BCS241005-Ausland STR 316 Tabelle D15a: Vorauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen AMAPA in % Tabelle D15b: Vorauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen AMAPA in % 5 Wie die Ergebnisse zeigen, weisen erfindungsgemäße Verbindungen der allgemeinen Formel (I) gemäß den Tabellen I.1 bis I.3 bei Behandlung im Vorauflauf eine gute herbizide Wirksamkeit gegen Schadpflanzen auf wie z. B. Abutilon theophrasti, Alopecurus myosuroides, Amaranthus retroflexus, Digitaria sanguinalis, Echinochloa crus-galli, Lolium rigidum, Matricaria inodora, Pharbitis purpurea, 10 Polygonum convolvulus, Setaria viridis, Veronica persica und Viola tricolor bei einer Aufwandmenge von 1280 g Aktivsubstanz oder weniger pro Hektar, auf. E. Wirkung auf Kulturpflanzen im Vorauflauf 15 Samen von mono- bzw. dikotylen Kulturpflanzen wurden in Kunststoff- oder organischen Pflanztöpfen ausgelegt und mit Erde abgedeckt. Die in Form von benetzbaren Pulvern (WP) oder als Emulsionskonzentrate (EC) formulierten erfindungsgemäßen Verbindungen wurden dann als wässrige Suspension bzw. Emulsion unter Zusatz von 0,5% Additiv mit einer Wasseraufwandmenge von umgerechnet 600 l/ha auf die Oberfläche der Abdeckerde appliziert. Nach der Behandlung wurden die 20 Töpfe im Gewächshaus aufgestellt und unter guten Wachstumsbedingungen für die Testpflanzen gehalten. Nach ca.3 Wochen wurde die Wirkung der Präparate visuell im Vergleich zu unbehandelten BCS241005-Ausland STR 317 Kontrollen in Prozentwerten bonitiert. Beispielsweise bedeutet 100% Wirkung = Pflanzen sind abgestorben, 0% Wirkung = wie Kontrollpflanzen. In den nachstehenden Tabellen E1 bis E4 sind die Wirkungen ausgewählter Verbindungen der 5 allgemeinen Formel (I) gemäß der Tabelle I.1 auf verschiedene Kulturpflanzen und einer Aufwandmenge entsprechend 1280 g/ha und niedriger, die gemäß zuvor genannter Versuchsvorschrift erhalten wurden, dargestellt. Tabelle E1a: Vorauflaufwirkung bei 1280 g/ha auf ZEAMX in % 10 BCS241005-Ausland STR 318 Tabelle E1b: Vorauflaufwirkung bei 320 g/ha auf ZEAMX in % BCS241005-Ausland STR 319 Tabelle E1c: Vorauflaufwirkung bei 80 g/ha auf ZEAMX in % BCS241005-Ausland STR 320 Tabelle E2a: Vorauflaufwirkung bei 1280 g/ha auf TRZAS in % BCS241005-Ausland STR 321 Tabelle E2b: Vorauflaufwirkung bei 320 g/ha auf TRZAS in % BCS241005-Ausland STR 322 Tabelle E2c: Vorauflaufwirkung bei 80 g/ha auf TRZAS in % BCS241005-Ausland STR 323 Tabelle E3a: Vorauflaufwirkung bei 1280 g/ha auf GLXMA in % BCS241005-Ausland STR 324 Tabelle E3b: Vorauflaufwirkung bei 320 g/ha auf GLXMA in % BCS241005-Ausland STR 325 BCS241005-Ausland STR 326 Tabelle E3c: Vorauflaufwirkung bei 80 g/ha auf GLXMA in % BCS241005-Ausland STR 327 Tabelle E4a: Vorauflaufwirkung bei 1280 g/ha auf BRSNW in % BCS241005-Ausland STR 328 Tabelle E4b: Vorauflaufwirkung bei 320 g/ha auf BRSNW in % 5 BCS241005-Ausland STR 329 Tabelle E4c: Vorauflaufwirkung bei 80 g/ha auf BRSNW in % BCS241005-Ausland STR 330 Wie die Ergebnisse zeigen, weisen erfindungsgemäße Verbindungen der allgemeinen Formel (I) bei Behandlung im Vorauflauf eine gute Kulturpflanzenverträglichkeit bei Organismen, wie Zea mays, Brassica napus, Glycine max und Triticum aestivum bei einer Aufwandmenge von 5 1280 g oder weniger pro Hektar. F. Herbizide Wirkung im Nachauflauf – Teil II Samen von mono- bzw. dikotylen Unkrautpflanzen wurden in Kunststoff- oder Holzfasertöpfen in 10 sandigem Lehmboden ausgelegt, mit Erde abgedeckt und im Gewächshaus unter kontrollierten Wachstumsbedingungen angezogen.2 bis 3 Wochen nach der Aussaat wurden die Versuchspflanzen im Einblattstadium behandelt. Die in Form von benetzbaren Pulvern (WP) oder als Emulsionskonzentrate (EC) formulierten erfindungsgemäßen Verbindungen wurden dann als wässrige Suspension bzw. Emulsion unter Zusatz von 0,5% Additiv mit einer Wasseraufwandmenge von umgerechnet 600 l/ha auf 15 die grünen Pflanzenteile gesprüht. Nach ca.3 Wochen Standzeit der Versuchspflanzen im Gewächshaus, unter optimalen Wachstumsbedingungen, wurde die Wirkung der Präparate visuell im Vergleich zu unbehandelten Kontrollen bonitiert. Beispielsweise bedeutet 100% Wirkung = Pflanzen sind abgestorben, 0% Wirkung = wie Kontrollpflanzen. 20 In den nachstehenden Tabellen F1 bis F15 sind die Wirkungen ausgewählter Verbindungen der allgemeinen Formel (I) gemäß der Tabelle I.1 auf verschiedene Schadpflanzen und einer Aufwandmenge entsprechend 1280 g/ha und niedriger, die gemäß zuvor genannter Versuchsvorschrift erhalten wurden, dargestellt. 25 BCS241005-Ausland STR 331 Tabelle F1a: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen ABUTH in % Tabelle F1b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen ABUTH in % BCS241005-Ausland STR 332 Tabelle F1c: Nachauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen ABUTH in % Tabelle F1d: Nachauflaufwirkung bei einer Aufwandmenge von 20 g/ha gegen ABUTH in % 5 Tabelle F1e: Nachauflaufwirkung bei einer Aufwandmenge von 5 g/ha gegen ABUTH in % Tabelle F1f: Nachauflaufwirkung bei einer Aufwandmenge von 1,25 g/ha gegen ABUTH in % Tabelle F2a: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen ALOMY in % BCS241005-Ausland STR 333 Tabelle F2b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen ALOMY in % Tabelle F2c: Nachauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen ALOMY in % 5 Tabelle F3a: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen AMARE in % BCS241005-Ausland STR 334 Tabelle F3b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen AMARE in % Tabelle F3c: Nachauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen AMARE in % 5 Tabelle F3d: Nachauflaufwirkung bei einer Aufwandmenge von 20 g/ha gegen AMARE in % Tabelle F4a: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen AVEFA in % BCS241005-Ausland STR 335 Tabelle F4b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen AVEFA in % Tabelle F4c: Nachauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen AVEFA in % 5 Tabelle F5a: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen DIGSA in % BCS241005-Ausland STR 336 Tabelle F5b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen DIGSA in % Tabelle F5c: Nachauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen DIGSA in % 5 Tabelle F6a: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen ECHCG in % BCS241005-Ausland STR 337 Tabelle F6b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen ECHCG in % Tabelle F6c: Nachauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen ECHCG in % 5 Tabelle F7a: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen LOLRI in % BCS241005-Ausland STR 338 Tabelle F7b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen LOLRI in % Tabelle F7c: Nachauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen LOLRI in % 5 BCS241005-Ausland STR 339 Tabelle F8b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen MATIN in % 5 Tabelle F8c: Nachauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen MATIN in % BCS241005-Ausland STR 340 Tabelle F8d: Nachauflaufwirkung bei einer Aufwandmenge von 20 g/ha gegen MATIN in % Tabelle F8e: Nachauflaufwirkung bei einer Aufwandmenge von 5 g/ha gegen MATIN in % 5 Tabelle F9a: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen PHBPU in % BCS241005-Ausland STR 341 Tabelle F9b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen PHBPU in % Tabelle F9c: Nachauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen PHBPU in % 5 Tabelle F9d: Nachauflaufwirkung bei einer Aufwandmenge von 20 g/ha gegen PHBPU in % Tabelle F9e: Nachauflaufwirkung bei einer Aufwandmenge von 5 g/ha gegen PHBPU in % BCS241005-Ausland STR 342 Tabelle F9f: Nachauflaufwirkung bei einer Aufwandmenge von 1,25 g/ha gegen PHBPU in % Tabelle F10a: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen POLCO in % 5 Tabelle F10b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen POLCO in % Tabelle F10c: Nachauflaufwirkung bei einer Aufwandmenge von 20 g/ha gegen POLCO in % Tabelle F10d: Nachauflaufwirkung bei einer Aufwandmenge von 5 g/ha gegen POLCO in % 10 BCS241005-Ausland STR 343 Tabelle F11a: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen SETVI in % Tabelle F11b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen SETVI in % 5 Tabelle F11c: Nachauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen SETVI in % BCS241005-Ausland STR 344 Tabelle F11d: Nachauflaufwirkung bei einer Aufwandmenge von 20 g/ha gegen SETVI in % Tabelle F11e: Nachauflaufwirkung bei einer Aufwandmenge von 5 g/ha gegen SETVI in % 5 Tabelle F12a: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen VERPE in % BCS241005-Ausland STR 345 Tabelle F12b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen VERPE in % BCS241005-Ausland STR 346 Tabelle F12c: Nachauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen VERPE in % Tabelle F12d: Nachauflaufwirkung bei einer Aufwandmenge von 20 g/ha gegen VERPE in % 5 Tabelle F12e: Nachauflaufwirkung bei einer Aufwandmenge von 5 g/ha gegen VERPE in % BCS241005-Ausland STR 347 Tabelle F12f: Nachauflaufwirkung bei einer Aufwandmenge von 1,25 g/ha gegen VERPE in % Tabelle F13a: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen VIOTR in % 5 Tabelle F13b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen VIOTR in % BCS241005-Ausland STR 348 Tabelle F13c: Nachauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen VIOTR in % Tabelle F13d: Nachauflaufwirkung bei einer Aufwandmenge von 20 g/ha gegen VIOTR in % BCS241005-Ausland STR 349 Tabelle F13e: Nachauflaufwirkung bei einer Aufwandmenge von 5 g/ha gegen VIOTR in % Tabelle F13f: Nachauflaufwirkung bei einer Aufwandmenge von 1,25 g/ha gegen VIOTR in % 5 Tabelle F14a: Nachauflaufwirkung bei einer Aufwandmenge von 1280 g/ha gegen KCHSC in % BCS241005-Ausland STR 350 Tabelle F14b: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen KCHSC in % Tabelle F14c: Nachauflaufwirkung bei einer Aufwandmenge von 80 g/ha gegen KCHSC in % BCS241005-Ausland STR 351 Tabelle F14d: Nachauflaufwirkung bei einer Aufwandmenge von 20 g/ha gegen KCHSC in % Tabelle F14e: Nachauflaufwirkung bei einer Aufwandmenge von 5 g/ha gegen KCHSC in % 5 Tabelle F15a: Nachauflaufwirkung bei einer Aufwandmenge von 320 g/ha gegen AMAPA in % Tabelle F15b: Nachauflaufwirkung bei einer Aufwandmenge von 20 g/ha gegen AMAPA in % 10 Tabelle F15c: Nachauflaufwirkung bei einer Aufwandmenge von 5 g/ha gegen AMAPA in % Tabelle F15d: Nachauflaufwirkung bei einer Aufwandmenge von 1,255 g/ha gegen AMAPA in % BCS241005-Ausland STR 352 Wie die Ergebnisse zeigen, weisen erfindungsgemäße Verbindungen der allgemeinen Formel (I) gemäß den Tabellen I.1 bis I.3 bei Behandlung im Nachauflauf eine gute herbizide Wirksamkeit gegen Schadpflanzen auf wie z. B. Abutilon theophrasti, Alopecurus myosuroides, Amaranthus retroflexus, 5 Digitaria sanguinalis, Echinochloa crus-galli, Lolium rigidum, Matricaria inodora, Pharbitis purpurea, Polygonum convolvulus, Setaria viridis, Veronica persica und Viola tricolor bei einer Aufwandmenge von 1280 g Aktivsubstanz oder weniger pro Hektar, auf. 10 G. Wirkung auf Kulturpflanzen im Nachauflauf Samen von mono- bzw. dikotylen Kulturpflanzen wurden in Kunststoff- oder Holzfasertöpfen in sandigem Lehmboden ausgelegt, mit Erde abgedeckt und im Gewächshaus unter kontrollierten Wachstumsbedingungen angezogen.2 bis 3 Wochen nach der Aussaat wurden die Versuchspflanzen im 15 Einblattstadium behandelt. Die in Form von benetzbaren Pulvern (WP) oder als Emulsionskonzentrate (EC) formulierten erfindungsgemäßen Verbindungen wurden dann als wässrige Suspension bzw. Emulsion unter Zusatz von 0,5% Additiv mit einer Wasseraufwandmenge von umgerechnet 600 l/ha auf die grünen Pflanzenteile gesprüht. Nach ca.3 Wochen Standzeit der Versuchspflanzen im Gewächshaus, unter optimalen Wachstumsbedingungen, wurde die Wirkung der Präparate visuell im Vergleich zu 20 unbehandelten Kontrollen bonitiert. Beispielsweise bedeutet 100% Wirkung = Pflanzen sind abgestorben, 0% Wirkung = wie Kontrollpflanzen. In den nachstehenden Tabellen G1 bis G4 sind die Wirkungen ausgewählter Verbindungen der 25 allgemeinen Formel (I) gemäß der Tabelle I.1 auf verschiedene Kulturpflanzen und einer Aufwandmenge entsprechend 1280 g/ha und niedriger, die gemäß zuvor genannter Versuchsvorschrift erhalten wurden, dargestellt. Tabelle G1a: Nachauflaufwirkung bei 1280 g/ha auf ZEAMX in % 30 BCS241005-Ausland STR 353 BCS241005-Ausland STR 354 Tabelle G1b: Nachauflaufwirkung bei 320 g/ha auf ZEAMX in % BCS241005-Ausland STR 355 Tabelle G1c: Nachauflaufwirkung bei 80 g/ha auf ZEAMX in % BCS241005-Ausland STR 356 Tabelle G1d: Nachauflaufwirkung bei 20 g/ha auf ZEAMX in % 5 Tabelle G1e: Nachauflaufwirkung bei 5 g/ha auf ZEAMX in % BCS241005-Ausland STR 357 Tabelle G1f: Nachauflaufwirkung bei 1,25 g/ha auf ZEAMX in % 5 Tabelle G2a: Nachauflaufwirkung bei 1280 g/ha auf TRZAS in % BCS241005-Ausland STR 358 Tabelle G2b: Nachauflaufwirkung bei 320 g/ha auf TRZAS in % BCS241005-Ausland STR 359 Tabelle G2c: Nachauflaufwirkung bei 80 g/ha auf TRZAS in % BCS241005-Ausland STR 360 Tabelle G2d: Nachauflaufwirkung bei 20 g/ha auf TRZAS in % 5 Tabelle G2e: Nachauflaufwirkung bei 5 g/ha auf TRZAS in % BCS241005-Ausland STR 361 Tabelle G2f: Nachauflaufwirkung bei 1,25 g/ha auf TRZAS in % 5 Tabelle G3a: Nachauflaufwirkung bei 1280 g/ha auf GLXMA in % BCS241005-Ausland STR 362 Tabelle G3b: Nachauflaufwirkung bei 320 g/ha auf GLXMA in % BCS241005-Ausland STR 363 Tabelle G3c: Nachauflaufwirkung bei 80 g/ha auf GLXMA in % BCS241005-Ausland STR 364 Tabelle G3d: Nachauflaufwirkung bei 20 g/ha auf GLXMA in % BCS241005-Ausland STR 365 Tabelle G3e: Nachauflaufwirkung bei 5 g/ha auf GLXMA in % 5 Tabelle G3f: Nachauflaufwirkung bei 1,25 g/ha auf GLXMA in % Tabelle G4a: Nachauflaufwirkung bei 1280 g/ha auf BRSNW in % BCS241005-Ausland STR 366 Tabelle G4b: Nachauflaufwirkung bei 320 g/ha auf BRSNW in % 5 BCS241005-Ausland STR 367 Tabelle G4c: Nachauflaufwirkung bei 80 g/ha auf BRSNW in % Wie die Ergebnisse zeigen, weisen erfindungsgemäße Verbindungen der allgemeinen Formel (I) bei 5 Behandlung im Nachauflauf eine gute Kulturpflanzenverträglichkeit bei Organismen, wie Zea mays, Brassica napus, Glycine max und Triticum aestivum bei einer Aufwandmenge von 1280 g oder weniger pro Hektar. BCS241005-Ausland STR 368 Insektizide Wirkung Aphis gossypii – Oraltest 5 Lösungsmittel: 100 Gewichtsteile Aceton Zur Herstellung einer geeigneten Wirkstoffzubereitung wird 1 Gewichtsteil Wirkstoff mit der angegebenen Menge Lösungsmittel vermischt und das Konzentrat mit Wasser auf die gewünschte Konzentration verdünnt. 10 50 µL Wirkstofflösung werden in Mikrotiterplatten gefüllt und 150 µL IPL41-Insektenmedium (33 % + 15 % Zucker) hinzugefügt, um ein Gesamtvolumen von 200 µL pro Vertiefung zu erhalten. Anschließend werden die Platten mit Parafilm verschlossen, durch den eine gemischte Population der Baumwollblattlaus (Aphis gossypii) an der Wirkstoffzubereitung saugen kann. 15 Nach 5 Tagen wird die Mortalität in % bestimmt.100 % bedeutet, dass alle Blattläuse abgetötet wurden, und 0 % bedeutet, dass keine Blattläuse abgetötet wurden. In diesem Test zeigten beispielsweise folgende Verbindungen aus den Herstellungsbeispielen eine gute 20 Wirksamkeit von 100 % bei einer Aufwandmenge von 100 ppm: I.1-48, I.2-27. Myzus persicae - Oraltest Lösungsmittel: 100 Gewichtsteile Aceton Zur Herstellung einer zweckmäßigen Wirkstoffzubereitung wird 1 Gewichtsteil Wirkstoff mit der 25 angegebenen Menge Lösungsmittel vermischt und das Konzentrat mit Wasser auf die gewünschte Konzentration verdünnt. 50 µL Wirkstofflösung werden in Mikrotiterplatten gefüllt und mit 150 µL IPL41 Insektenmedium (33 % + 15 % Zucker) versetzt, um ein Gesamtvolumen von 200 µL pro Vertiefung zu erhalten. 30 Anschließend werden die Platten mit Parafilm verschlossen, durch den eine Mischpopulation der Grünen Pfirsichblattlaus (Myzus persicae) an der Wirkstoffzubereitung saugen kann. Nach 8 Tagen wird die Mortalität in % bestimmt.100 % bedeutet, dass alle Blattläuse abgetötet wurden und 0 % bedeutet, dass keine Blattläuse abgetötet wurden. In diesem Test zeigten beispielsweise 35 folgende Verbindungen aus den Herstellungsbeispielen eine gute Wirksamkeit von 90 % bei einer Aufwandmenge von 20 ppm: I.1-176. BCS241005-Ausland STR 369 Spodoptera frugiperda - Sprühtest Lösungsmittel: 78,0 Gewichtsteile Aceton 1,5 Gewichtsteile Dimethylformamid Emulgator: Alkylarylpolyglykolether 5 Zur Herstellung einer zweckmäßigen Wirkstoffzubereitung vermischt man 1 Gewichtsteil Wirkstoff mit der angegebenen Menge Lösungsmittel und verdünnt mit Wasser, das eine Emulgatorkonzentration von 1000 ppm enthält, auf die gewünschte Konzentration. Weitere Testkonzentrationen werden durch Verdünnen mit wasserhaltigem Emulgator hergestellt. 10 Mais (Zea mays)-Blattstücke werden mit einer Wirkstoffzubereitung der gewünschten Konzentration besprüht. Nach dem Trocknen werden die Blattstücke mit Larven des Herbst-Heerwurms (Spodoptera frugiperda) befallen. Nach 7 Tagen wird die Mortalität in % ermittelt.100 % bedeutet, dass alle Raupen abgetötet wurden und 0 % bedeutet, dass keine Raupen abgetötet wurden. 15 In diesem Test zeigten beispielsweise folgende Verbindungen aus den Herstellungsbeispielen eine gute Wirkung von 100 % bei einer Aufwandmenge von 100 g/ha: I.2-13. In diesem Test zeigten beispielsweise folgende Verbindungen aus den Herstellungsbeispielen eine gute Wirkung von 100 % bei einer Aufwandmenge von 20 g/ha: I.1-440, I.2-96, I.2-139. 20 Meloidogyne incognita - Test Lösungsmittel: 125,0 Gewichtsteile Aceton Zur Herstellung einer zweckmäßigen Wirkstoffzubereitung vermischt man 1 Gewichtsteil Wirkstoff mit der angegebenen Menge Lösungsmittel und verdünnt das Konzentrat mit Wasser auf die gewünschte 25 Konzentration. Gefäße werden mit Sand, einer Lösung des Wirkstoffs, einer Suspension, die Eier und Larven des südlichen Wurzelgallennematoden (Meloidogyne incognita) enthält, und Salatsamen gefüllt. Die Salatsamen keimen und die Sämlinge wachsen. In den Wurzeln entwickeln sich Gallen. Nach 14 Tagen wird die nematizide Wirkung in Prozent anhand der Bildung von Gallen bestimmt.100 % bedeutet, dass keine Gallen gefunden wurden und 0 % bedeutet, dass die Anzahl der an den Wurzeln der 30 behandelten Pflanzen gefundenen Gallen gleich der Anzahl der unbehandelten Kontrollpflanzen war. In diesem Test zeigten beispielsweise folgende Verbindungen aus den Herstellungsbeispielen eine gute Wirkung von 90 % bei einer Aufwandmenge von 20 ppm: I.1-52. BCS241005-Abroad STR 1 Bayer AG Substituted Arylpyrazines and their Salts and their Use as Herbicidal Active Ingredients 5 Description The invention relates to the technical field of plant protection products, in particular herbicides for the selective control of weeds and grasses in crops. 10 Specifically, this invention relates to substituted arylpyrazines and their salts, processes for their production, and their use as herbicides, in particular for controlling weeds and/or grasses in crops and/or as plant growth regulators to influence the growth of crops. 15. Previously known plant protection products for the selective control of weeds in crops or active ingredients for controlling unwanted plant growth have some disadvantages in their application, be it that they (a) have no or insufficient herbicidal activity against certain weeds, (b) have too narrow a spectrum of weeds that can be controlled with one active ingredient, (c) have insufficient selectivity in crops 20, and/or (d) have an unfavorable toxicological profile. Furthermore, some active ingredients that can be used as plant growth regulators in some crops lead to undesirably reduced yields in other crops or are not compatible with the crop or only within a narrow application rate range. Some of the known active ingredients cannot be produced economically on an industrial scale 25 due to difficult-to-access precursors and reagents or have insufficient chemical stability. For other active ingredients, the effect depends too strongly on environmental conditions, such as weather and soil conditions. The herbicidal activity of these known compounds, particularly at low application rates, and their compatibility with crops remain in need of improvement. It is known from various publications that certain substituted heteroaryltriazoles and heteroaryltetrazoles can be used as active ingredients against ectoparasites in animals or against insects to prevent feeding damage in crops (see WO 2017/192385, WO 2019/170626 and WO 2019/215198). Other heteroaryltriazoles and heteroaryltetrazoles, as well as their insecticidal activity when applied to crops, have also been described (see WO 2019/201835, WO 2019/197468, WO 2019/202077, WO 2019/206799, WO 2023/037249). It is known from various publications that certain substituted heteroaryltriazoles and heteroaryltetrazoles can be used as active ingredients against ectoparasites in animals or against insects to prevent feeding damage in crops. BCS241005-Abroad STR 2 It is also known that certain azolamides can be used as insecticidal active ingredients (WO2020/002563, WO2020/053364, WO2020/053365, WO2020/079198). Furthermore, it is known that substituted heteroaryloxazoles and heteroarylthiazoles also exhibit insecticidal effects (see WO2023/110473). 5 It is also known that substituted heteroarylpyrazines can be used as insecticidal active ingredients (see WO2020/201079; WO2020/208036, WO2020/201398, WO2021/069575, WO2021/068179, WO2022/258481). Substituted N-(arylpyrazinylalkyl)carboxamides with herbicidal activity, however, have not yet been described. While substituted arylquinoxalines and their use as PI3 kinase inhibitors (see WO2016/054491) have also been described, substituted N-(arylpyrazinylalkyl)carboxamides with substituted pyrazinylbenzoic acid groups have not yet been described. Surprisingly, it has now been found that certain substituted arylpyrazines or their salts 15 are well suited as herbicides and can be used particularly advantageously as active ingredients for controlling monocotyledonous and dicotyledonous weeds in crops. An object of the present invention is thus substituted arylpyrazines of general formula (I) or their salts, 20 where M is for one of the groups M-1 M-2 M-325, where the dashed line marks the link to the rest of formula (I), BCS241005-Abroad STR 3 R1R stands for aryl or heteroaryl, wherein the aryl or heteroaryl group is optionally further substituted by 1, 2 or 3 independently chosen substituents bonded to ring carbon atoms4, and where, if necessary, two adjacent substituents R4with the ring carbon atoms to which they are bonded, can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, 10 or R1stands for a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen and sulfur, and wherein the heterocyclyl residue is optionally substituted 15 by one, two or three substituents, which are independently chosen from a group (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C1-C6)-Cycloalkyl, (C1-C6)-Alkoxy, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl, 20 R2for hydrogen, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C1-C8)-Cyanoalkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C2-C8)-Alkenyl, (C2-C8)-Haloalkenyl, (C2-C8)-Alkynyl, (C2-C8)-Haloalkynyl, NR11R12, S(O)R14, SO2R14, C(O)OR13, C(O)R13or for aryl-(C1-C8)-alkyl, wherein the aryl group optionally carries 1 to 5 further substituents, which can be independently substituted for halogen, cyano, nitro, trimethylsilyl, pentafluorosulfanyl, -C(=S)NH2, OR13, NR11R12, SR14,25 S(O)R14, SO2R14, C(O)OR13, C(O)R13, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C2-C8)-Alkenyl, (C2-C8)-Haloalkenyl, (C2-C8)-Alkynyl, (C2-C8)-Haloalkynyl, (C3- C8)-Cycanocycloalkyl, (C3-C6)-Halocycloalkyl, (C1-C8)-Haloalkyl, (C1-C8)-Cyanoalkyl stands for, or for heteroaryl-(C1-C8)-alkyl, heterocyclyl-(C1-C8)-alkyl and wherein heterocyclyl carries n oxo groups, 30 R3for (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C2-C8)-Alkenyl, R13O-(C1-C8)-alkyl, (C3-C8)- Cycloalkyl-(C1-C8)-alkyl stands, R4for Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorosulfanyl, Nitro, Aryldiazo, 35 NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1-C8)-alkyl, OSO2-(C1-C8)-haloalkyl, OSO2-(C3-C8)-cycloalkyl, C(O)OR13, C(O)R13, C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C8)-alkyl, R13O-(C1-C8)-alkyl, R14S-(C1- BCS241005-Abroad STR 4 C8)-alkyl, R13(O)C-(C1-C8)-alkyl, (C1-C8)-Alkyl, cyano-(C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2- C8)-Alkynyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C2-C8)-Haloalkynyl, (C3-C10)-Cycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)- Haloalkoxy-(C1-C8)-haloalkyl, aryl, aryl-(C1-C8)-alkyl, heteroaryl, heteroaryl-(C1-C8)-alkyl, 5 (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-haloalkyl, (C4-C10)-Cycloalkenyl- (C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-haloalkyl, heterocyclyl, heterocyclyl-(C1-C8)- alkyl, aryl-(C1-C8)-alkynyl, heteroaryl-(C1-C8)-alkynyl, heterocyclyl-(C1-C8)-alkynyl, Tris-[(C1- C8)-alkyl]silyl-(C2-C8)-alkynyl, Bis-[(C1-C8)-alkyl](aryl)silyl-(C2-C8)-alkynyl, Bis-aryl[(C1-C8)- alkyl]silyl-(C2-C8)-alkynyl, (C3-C8)-Cycloalkyl-(C2-C8)-alkynyl, aryl-(C2-C8)-alkenyl, 10 Heteroaryl-(C2-C8)-alkenyl, heterocyclyl-(C2-C8)-alkenyl, (C3-C8)-Cycloalkyl-(C2-C8)-alkenyl, cyano-(C3-C8)-cycloalkylaminosulfonylamino, Tris-[(C1-C8)-alkyl]silyl, Bis-[(C1-C8)-alkyl](aryl)silyl, bis-aryl[(C1-C8)-alkyl]silyl, wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and 15 (C1-C8)-Alkylsulfonyl and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, R5, R6independently for hydrogen, halogen, cyano, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Halocycloalkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkynyl, R13O-(C1-C8)- 20 alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, -C=NOR13stand, R7for hydrogen, halogen, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C1-C8)-Alkoxy, (C1-C8)- Haloalkoxy, (C1-C8)-Haloalkyl stands for, 25 Q for hydroxy or a residue of the following formulas Q-1 Q-2 standsR8for hydrogen, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, heteroaryl, 30 (C2-C8)-Alkynyl, (C2-C8)-Alkenyl, C(O)R13, C(O)OR13, (C1-C8)-Alkoxy-(C1-C8)-alkyl stands, R9for hydrogen or (C1-C8)-Alkyl stands for, BCS241005-Abroad STR 5 R10for hydrogen, halogen, cyano, NO2, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C3-C8)-Halocycloalkyl, (C3-C8)-Halocycloalkyl-(C1-C8)- alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkynyl, Aryl, Aryl-(C1-C8)-alkyl, heteroaryl, heteroaryl-(C1- C8)-alkyl, heterocyclyl, heterocyclyl-(C1-C8)-alkyl, R11R12N-(C1-C8)-alkyl, R13O-(C1-C8)-alkyl, 5 cyano-(C1-C8)-alkyl, (C1-C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl- carbonyloxy-(C1-C8)-alkyl, arylcarbonyloxy-(C1-C8)-alkyl, heteroarylcarbonyloxy-(C1-C8)-alkyl, heterocyclylcarbonyloxy-(C1-C8)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- C8)-alkyl, R14(O)S-(C1-C8)-alkyl, R14O2S-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis-[(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, Tris- 10 [(C1-C8)-Alkyl]silyl, bis-hydroxyboryl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkoxy]boryl-(C1-C8)-alkyl, tetramethyl-1,3,2-dioxaborolan-2-yl, tetramethyl-1,3,2-dioxaborolan-2-yl-(C1-C8)-alkyl, Nitro-(C1-C8)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1C8)-alkyl, R11R12N(O)C- (C1-C8)-alkyl, Bis-(C1-C8)-alkoxy-(C1-C8)-alkyl, where heterocyclyl carries n oxo groups, or 15 R8and R10with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 20 R11and R12are the same or different and independent of each other for hydrogen, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkynyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkynyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4- C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1- C8)-Alkylthio-(C1-C8)-alkyl, (C1-C8)-Haloalkylthio-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-25 haloalkyl, aryl, aryl-(C1-C8)-alkyl, heteroaryl, heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C8)- Alkoxycarbonyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-amino-carbonyl-(C1-C8)-alkyl, aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, aryl-(C1-C8)-alkoxycarbonyl, heteroaryl-(C1-C8)-alkoxycarbonyl, (C2-C8)-Alkenyloxycarbonyl, (C2-C8)- 30 alkynyloxycarbonyl, heterocyclyl-(C1-C8)-alkyl, where heterocyclyl carries n oxo groups, or R11and R12with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by further heteroatoms and optionally further substituted 35 times, monocyclic or bicyclic ring with 3 to 10 members, BCS241005-Abroad STR 6 R13for hydrogen, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkynyl, (C1-C8)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkynyl, (C3-C10)-Cycloalkyl, (C4-C10)- Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy- (C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, 5 (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy- (C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, aryl, aryl-(C1-C8)-alkyl, aryl-(C1-C8)-alkoxy- (C1-C8)-alkyl, heteroaryl, heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-aminocarbonyl-(C1-C8)-alkyl, aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Bis-[(C1-C8)-10 alkyl]amino-(C2-C6)-alkyl, (C1-C8)-Alkyl-amino-(C2C6)-alkyl, aryl-(C1-C8)-alkylamino-(C2-C6)- alkyl, R14S-(C1-C8)-alkyl, R14(O)S-(C1-C8)-alkyl, R14O2S-(C1-C8)-alkyl, hydroxycarbonyl-(C1- C8)-alkyl, heterocyclyl, heterocyclyl-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis-[(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, (C1- C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkylcarbonyloxy-(C1-C8)-alkyl, 15 arylcarbonyloxy-(C1-C8)-alkyl, heteroarylcarbonyloxy-(C1-C8)-alkyl, heterocyclylcarbonyloxy-(C1-C8)-alkyl, aryloxy-(C1-C8)-alkyl, heteroaryloxy-(C1-C8)-alkyl, (C1-C8)-Alkoxycarbonyl, wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1-C8)- 20 Alkylsulfonyl, R14for (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkynyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkynyl, (C3-C10)-Cycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)- Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-25 (C1-C8)-alkyl, heteroaryl, heteroaryl-(C1-C8)-alkyl, heterocyclyl-(C1-C8)-alkyl, (C3-C8)- Cycloalkyl-(C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, Amino, Bis-[(C1-C8)- alkyl]amino, (C1-C8)-Alkyl-amino, Aryl-(C1-C8)-amino, Aryl-(C1-C6)-alkyl-amino, aryl-[(C1- C8)-alkyl]amino, (C3-C8)-Cycloalkyl-amino, (C3-C8)-Cycloalkyl-[(C1-C8)-alkyl]amino, N-acetidinyl, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, 30 wherein the last twelve listed residues (i.e. amino, bis-[(C1-C8)-alkyl]amino, (C1-C8)- Alkyl-amino, aryl-(C1-C8)-amino, Aryl-(C1-C6)-alkyl-amino, aryl-[(C1-C8)-alkyl]amino, (C3- C8)-Cycloalkyl-amino, (C3-C8)-Cycloalkyl-[(C1-C8)-alkyl]amino, N-acetidinyl, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl) are only bonded to sulfonyl groups, and wherein heterocyclyl carries n oxo groups, 35 and wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-Alkylsulfonyl, ````````````````````) ... ( ( ( (; (; (; (; (; (; (; (; (; (; (? (? (? (? (?)`)`)`)`)`)`)`) BCS241005-Abroad STR 7 R15and R16independently of each other for (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, Aryl, Heteroaryl, Heterocyclyl, where Heterocyclyl carries n oxo groups, or 5 R15and R16with the carbon atom to which they are bonded, they form a fully saturated monocyclic carbocycle of 3 to 7 members, R17, R18, R19and R20independently of each other for hydrogen, halogen, (C1-C8)-Alkyl, (C1-C8)-Alkoxy, (C1-C8)-Haloalkoxy, (C3-C8)-Cycloalkyl, (C1-C8)-haloalkyl, 10 and n stand for 0, 1 or 2. 15 The compounds of general formula (I) can be modified by addition of a suitable inorganic or organic acid, such as mineral acids, for example HCl, HBr, H2SO4, H3PO4or ENT3Organic acids, e.g., carboxylic acids such as formic acid, acetic acid, propionic acid, oxalic acid, lactic acid, or salicylic acid, or sulfonic acids such as p-toluenesulfonic acid, react with a basic group, such as an amino, alkylamino, dialkylamino, piperidino, morpholino, or pyridino, to form salts. These salts then contain the conjugate base of the acid as an anion. Suitable substituents that exist in deprotonated form, such as sulfonic acids, certain sulfonamides, or carboxylic acids, can form internal salts with their own protonatable groups, such as amino groups. Salt formation can also occur through the action of a base on compounds of the general formula (I). Suitable bases include, for example, organic amines such as trialkylamines, morpholine, piperidine, and pyridine, as well as ammonium, alkali, or alkaline earth metal hydroxides, carbonates, and bicarbonates, in particular sodium and potassium hydroxide, sodium and potassium carbonate, and sodium and potassium bicarbonate. These salts are compounds in which the acidic hydrogen is replaced by a cation suitable for agriculture, for example, metal salts, in particular alkali metal salts or alkaline earth metal salts, in particular sodium and potassium salts, or also ammonium salts, salts with organic amines, or quaternary ammonium salts, for example, with cations of the formula [NRaRbRcRd]+, in which Rato RdEach independently represents an organic residue, in particular alkyl, aryl, aralkyl, or alkylaryl. Alkylsulfonium and alkylsulfoxonium salts, such as (C1-C4)-Trialkylsulfonium- and (C1-C4)-Trialkylsulfoxonium salts. 35 The compounds of general formula (I) can exist as stereoisomers depending on the type and combination of the substituents. The possible stereoisomers defined by their specific spatial shape, BCS241005-Abroad STR 8, such as enantiomers, diastereomers, Z- and E-isomers, are all encompassed by formula (I). For example, if one or more alkenyl groups are present, diastereomers (Z- and E-isomers) can occur. If, for example, one or more asymmetrically substituted carbon atoms are present, enantiomers and diastereomers can occur. Stereoisomers can be obtained from the mixtures obtained during step 5 of the preparation using standard separation methods. Chromatographic separation can be performed both on an analytical scale to determine the enantiomeric or diastereomeric excess, and on a preparative scale to prepare test samples for biological testing. Stereoisomers can also be selectively prepared by using stereoselective reactions with optically active starting materials and/or excipients. The invention thus also relates to all stereoisomers encompassed by the general formula (I) but not specified with their specific stereoform, as well as their mixtures. Separated enantiomers encompassed by the general formula (I) are either (a) designated according to their optical activity with (+)- and (-), i.e., isomers that rotate plane-polarized light clockwise ((+)-direction) are designated with "(+)" 15; (b) classified into R- and S-enantiomers according to the Cahn-Ingold-Prelog rules; or (c) designated according to their retention time upon separation by chiral chromatography with "Ent-1" and "Ent-2". Methods for separating enantiomers are well known in the prior art, e.g., separation by chiral chromatography. 20 If the compounds are obtained as solids, purification can also be carried out by recrystallization or digestion. Individual compounds (I) can also be prepared by derivatizing other compounds (I). Methods generally known to those skilled in the art from analogous cases are suitable for isolating, purifying, and separating the stereoisomers of compounds of formula 25 (I). These methods include physical processes such as crystallization, chromatographic processes, especially column chromatography and HPLC (high-performance liquid chromatography), distillation, optionally under reduced pressure, extraction, and other processes. Any remaining mixtures can generally be separated by chromatographic separation, e.g., on chiral solid phases. 30 For preparative quantities or on an industrial scale, methods such as crystallization are suitable, e.g., of diastereomeric salts, which can be obtained from the diastereomeric mixtures with optically active acids and, optionally, with optically active bases if acidic groups are present. 35 In the following, the compounds of formula (I) and their salts used according to the invention are referred to as "compounds of general formula (I)". BCS241005-Abroad STR 9 Preferred subject matter of the invention is compounds of the general formula (I), wherein M represents one of the groups M-1 M-2 M-35, where the dashed line marks the link to the rest of formula (I), R1for aryl or heteroaryl, 10 wherein the aryl or heteroaryl group is optionally further substituted by 1, 2 or 3 substituents bonded to ring carbon atoms and chosen independently of one another R4, and where, if necessary, two adjacent substituents R4with the ring carbon atoms to which they are bonded, they can form a saturated, partially saturated or 15 unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, or R1represents a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, 20 wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen and sulfur, and wherein the heterocyclyl residue is optionally substituted by one, two or three substituents, which are independently chosen from a group (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C1-C6)-Cycloalkyl, (C1-C6)-Alkoxy, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkoxy, halogen, aryl, heteroaryl, 25 (heterocyclyl)aryl; R2for hydrogen, (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C1-C7)-Cyanoalkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C2-C7)-Alkenyl, (C2-C7)-Haloalkenyl, (C2-C7)-Alkynyl, (C2-C7)-Haloalkynyl, NR11R12, S(O)R14, SO2R14, C(O)OR13, C(O)R13or for aryl-(C1-C7)-alkyl, wherein the 30 aryl group optionally carries 1 to 5 further substituents, which can be independently substituted for halogen, cyano, nitro, trimethylsilyl, pentafluorosulfanyl, -C(=S)NH2, OR13, NR11R12, SR14, S(O)R14, SO2R14, C(O)OR13, C(O)R13, (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Cycloalkyl- ```````````````````) ...)`))`)))))))) Cycloalkyl ` ` ` ` ` ` BCS241005-Abroad STR 10 (C)1-C7)-alkyl, (C2-C7)-Alkenyl, (C2-C7)-Haloalkenyl, (C2-C7)-Alkynyl, (C2-C7)-Haloalkynyl, (C3- C7)-Cycanocycloalkyl, (C3-C7)-Halocycloalkyl, (C1-C7)-Haloalkyl, (C1-C7)-Cyanoalkyl stands for, or for heteroaryl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkyl and wherein heterocyclyl carries n oxo groups, 5 R3for (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C2-C7)-Alkenyl, R13O-(C1-C7)-alkyl, (C3-C7)- Cycloalkyl-(C1-C7)-alkyl stands, R4for Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorosulfanyl, Nitro, Aryldiazo, 10 NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1-C7)-alkyl, OSO2-(C1-C7)-haloalkyl, OSO2-(C3-C7)-cycloalkyl, C(O)OR13, C(O)R13C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C7)-alkyl, R13O-(C1-C7)-alkyl, R13S-(C1- C7)-alkyl, R13(O)C-(C1-C7)-alkyl, (C1-C7)-Alkyl, cyano-(C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2- C7)-Alkynyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C2-C7)-Haloalkynyl, (C3-C7)-Cycloalkyl,15 (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)- Haloalkoxy-(C1-C7)-haloalkyl, aryl, aryl-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-haloalkyl, (C4-C7)-Cycloalkenyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-haloalkyl, heterocyclyl, heterocyclyl-(C1-C7)- alkyl, aryl-(C1-C7)-alkynyl, heteroaryl-(C1-C7)-alkynyl, heterocyclyl-(C1-C7)-alkynyl, Tris-[(C1-20°C7)-alkyl]silyl-(C2-C7)-alkynyl, Bis-[(C1-C7)-alkyl](aryl)silyl-(C2-C7)-alkynyl, Bis-aryl[(C1-C7)- alkyl]silyl-(C2-C7)-alkynyl, (C3-C7)-Cycloalkyl-(C2-C7)-alkynyl, aryl-(C2-C7)-alkenyl, heteroaryl-(C2-C7)-alkenyl, heterocyclyl-(C2-C7)-alkenyl, (C3-C7)-Cycloalkyl-(C2-C7)-alkenyl, cyano-(C3-C7)-Cycloalkylaminosulfonylamino, Tris-[(C1-C7)-alkyl]silyl, Bis-[(C1-C7)-alkyl](aryl)silyl, bis-aryl[(C1-C7)-alkyl]silyl and wherein heterocyclyl carries n oxo groups 25 and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-Alkylsulfonyl and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, 30 R5, R6independently for hydrogen, halogen, cyano, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkynyl, R13O-(C1-C7)- alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, -C=NOR13standing, 35 R7for hydrogen, halogen, (C1-C7)-Alkyl, (C1-C7)-Alkoxy, (C1-C7)-Haloalkoxy, (C3-C7)- Cycloalkyl, (C1-C7)-Haloalkyl stands for, BCS241005-Abroad STR 11 Q for hydroxy or any of the following formulas ``` Q-1 Q-2 standsR8for hydrogen, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, heteroaryl, 5 (C2-C7)-Alkynyl, (C2-C7)-Alkenyl, C(O)R13, C(O)OR13, (C1-C7)-Alkoxy-(C1-C7)-alkyl stands, R9for hydrogen or (C1-C7)-Alkyl stands, R10for hydrogen, halogen, cyano, NO2, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl,10 (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C3-C7)-Halocycloalkyl, (C3-C7)-Halocycloalkyl-(C1-C7)- alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkynyl, Aryl, Aryl-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1- C7)-alkyl, heterocyclyl, heterocyclyl-(C1-C7)-alkyl, R11R12N-(C1-C7)-alkyl, R13O-(C1-C7)-alkyl, cyano-(C1-C7)-alkyl, (C1-C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- carbonyloxy-(C1-C7)-alkyl, arylcarbonyloxy-(C1-C7)-alkyl, heteroarylcarbonyloxy-(C1-C7)-15 alkyl, heterocyclylcarbonyloxy-(C1-C7)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- C7)-alkyl, R14(O)S-(C1-C7)-alkyl, R14O2S-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, Tris- [(C1-C7)-Alkyl]silyl, bis-hydroxyboryl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkoxy]boryl-(C1-C7)-alkyl, tetramethyl-1,3,2-dioxaborolan-2-yl, tetramethyl-1,3,2-dioxaborolan-2-yl-(C1-C7)-alkyl,20 Nitro-(C1-C7)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1-C7)-alkyl, R11R12N(O)C- (C1-C7)-alkyl, Bis-(C1-C7)-alkoxy-(C1-C7)-alkyl and wherein heterocyclyl carries n oxo groups, or R8and R10with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, R11and R12are the same or different and independent of each other for hydrogen, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkynyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl,30 (C3-C7)-Haloalkynyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4- C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1- C7)-Alkylthio-(C1-C7)-alkyl, (C1-C7)-Haloalkylthio-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)- haloalkyl, aryl, aryl-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C7)- ``` BCS241005-Abroad STR 12 Alkoxycarbonyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl-amino-carbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxycarbonyl, heteroaryl-(C1-C7)-alkoxycarbonyl, (C2-C7)-Alkenyloxycarbonyl, (C2-C7)-alkynyloxycarbonyl, heterocyclyl-(C1-C7)-alkyl and where heterocyclyl carries n oxo groups 5, or R11and R12with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 10 R13for hydrogen, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkynyl, (C1-C7)-Cyanoalkyl, (C1-C7)- Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkynyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-15 Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)- alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, aryl, aryl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxy-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C7)- Cycloalkenyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl-aminocarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, Bis-[(C1-C7)-20 alkyl]amino-(C2-C6)-alkyl, (C1-C7)-Alkyl-amino-(C2-C6)-alkyl, aryl-(C1-C7)-alkyl-amino-(C2- C6)-alkyl, R14S-(C1-C7)-alkyl, R14(O)S-(C1-C7)-alkyl, R14O2S-(C1-C7)-alkyl, hydroxycarbonyl- (C1-C7)-alkyl, heterocyclyl, heterocyclyl-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, (C1- C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkylcarbonyloxy-(C1-C7)-alkyl, 25 arylcarbonyloxy-(C1-C7)-alkyl, heteroarylcarbonyloxy-(C1-C7)-alkyl, heterocyclylcarbonyloxy-(C1-C7)-alkyl, aryloxy-(C1-C7)-alkyl, heteroaryloxy-(C1-C7)-alkyl, (C1-C7)-Alkoxycarbonyl and wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1-30°C8)-Alkylsulfonyl, R14for (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkynyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkynyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)- Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-35 (C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkyl, (C3-C7)- Cycloalkyl-(C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, Amino, Bis-[(C1-C7)- alkyl]amino, (C1-C7)-Alkyl-amino, Aryl-(C1-C7)-amino, Aryl-(C1-C6)-alkyl-amino, aryl-[(C1- BCS241005-Abroad STR 13 C7)-alkyl]amino; (C3-C7)-Cycloalkyl-amino, (C3-C7)-Cycloalkyl-[(C1-C7)-alkyl]amino, N-acetidinyl, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, wherein the last twelve mentioned residues are only bonded to sulfonyl groups and wherein heterocyclyl carries n oxo groups, and wherein cycloalkyl can be substituted by one or more substituents selected from 5 of a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-Alkylsulfonyl, R15and R16independently of each other for (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, Aryl, Heteroaryl, Heterocyclyl and where Heterocyclyl carries n oxo groups, or 10 R15and R16with the carbon atom to which they are bonded, they form a fully saturated monocyclic carbocycle of 3 to 7 members, R17, R18, R19and R20independently of each other for hydrogen, halogen, (C1-C7)-Alkyl, (C1-C7)-Alkoxy, 15 (C1-C7)-Haloalkoxy, (C3-C7)-Cycloalkyl, (C1-C7)-haloalkyl and n represents 0, 1 or 2. 20 Particularly preferred subject matter of the invention is compounds of the general formula (I), wherein M represents the groups M-1 M-2 M-325, where the dashed line marks the link to the rest of formula (I), R1for aryl or heteroaryl, 30 wherein the aryl or heteroaryl group is optionally further substituted by 1, 2 or 3 substituents bonded to ring carbon atoms and chosen independently of one another R4, BCS241005-Abroad STR 14 and where, if applicable, two adjacent substituents R4with the ring carbon atoms to which they are bonded, can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, 5 or R1stands for a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen and sulfur, and wherein the heterocyclyl residue is optionally substituted 10 by one, two or three substituents, which are independently chosen from a group (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C1-C6)-Cycloalkyl, (C1-C6)-Alkoxy, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl; 15 r2stands for hydrogen, R3for (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, R13O-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl stands, 20 R4for halogen, cyano, thiocyanate, isothiocyanate, pentafluorosulfanyl, nitro, aryldiazo, NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1-C6)-alkyl, OSO2-(C1-C6)-haloalkyl, OSO2-(C3-C6)-cycloalkyl, C(O)OR13, C(O)R13C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, R13S-(C1- C6)-alkyl, R13(O)C-(C1-C6)-alkyl, (C1-C6)-Alkyl, cyano-(C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-25°C6)-Alkynyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)- Haloalkoxy-(C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-haloalkyl, (C4-C6)-Cycloalkenyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-haloalkyl, heterocyclyl, heterocyclyl-(C1-C6)-30 alkyl, aryl-(C1-C6)-alkynyl, heteroaryl-(C1-C6)-alkynyl, heterocyclyl-(C1-C6)-alkynyl, Tris-[(C1- C6)-alkyl]silyl-(C2-C6)-alkynyl, Bis-[(C1-C6)-alkyl](aryl)silyl-(C2-C6)-alkynyl, Bis-aryl[(C1-C6)- alkyl]silyl-(C2-C6)-alkynyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkynyl, aryl-(C2-C6)-alkenyl, heteroaryl-(C2-C6)-alkenyl, heterocyclyl-(C2-C6)-alkenyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkenyl, cyano-(C3-C6)-Cycloalkylaminosulfonylamino, Tris-[(C1-C6)-alkyl]silyl, Bis-[(C1-C6)- 35 alkyl](aryl)silyl, bis-aryl[(C1-C6)-alkyl]silyl and wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl BCS241005-Abroad STR 15 and (C1-C8)-Alkylsulfonyl and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, R5, R6independently of each other for hydrogen, halogen, (C1-C6)-Alkyl stand, 5 R7for hydrogen, halogen, (C1-C6)-Alkyl, (C1-C7)-Alkoxy, (C1-C7)-Haloalkoxy, (C3-C6)- Cycloalkyl, (C1-C6)-Haloalkyl stands for, Q for hydroxy or a residue of the following formulas ... 10 Q-1 Q-2 stands,R8for hydrogen, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, heteroaryl, (C2-C6)-Alkynyl, (C2-C6)-Alkenyl, C(O)R13, C(O)OR13, (C1-C6)-Alkoxy-(C1-C6)-alkyl stands, 15 R9for hydrogen or (C1-C6)-Alkyl stands, R10for hydrogen, halogen, cyano, NO2, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Halocycloalkyl-(C1-C6)- alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, Aryl, Aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-20°C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R11R12N-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, cyano-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- carbonyloxy-(C1-C6)-alkyl, arylcarbonyloxy-(C1-C6)-alkyl, heteroarylcarbonyloxy-(C1-C6)-alkyl, heterocyclylcarbonyloxy-(C1-C6)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- C6)-alkyl, R14(O)S-(C1-C6)-alkyl, R14O2S-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl,25 Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, Tris- [(C1-C6)-Alkyl]silyl, bis-hydroxyboryl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkoxy]boryl-(C1-C6)-alkyl, tetramethyl-1,3,2-dioxaborolan-2-yl, tetramethyl-1,3,2-dioxaborolan-2-yl-(C1-C6)-alkyl, Nitro-(C1-C6)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1-C6)-alkyl, R11R12N(O)C- (C1-C6)-alkyl, Bis-(C1-C6)-alkoxy-(C1-C6)-alkyl and wherein heterocyclyl carries n oxo groups 30, or R8and R10with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3- to 10-membered monocyclic or bicyclic ring, BCS241005-Abroad STR 16 R11and R12are the same or different and independent of each other for hydrogen, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-5°C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1- C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C6)- Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-amino-10 carbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl, heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)-alkynyloxycarbonyl, heterocyclyl-(C1-C6)-alkyl and where heterocyclyl carries n oxo groups, or 15 R11and R12with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, R13for hydrogen, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, (C1-C6)-Cyanoalkyl, (C1-C6)- 20 Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, aryl, aryl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxy-(C1-C6)-25 alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)- alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, aryl-(C1-C6)-alkyl-amino-(C2- C6)-alkyl, R14S-(C1-C6)-alkyl, R14(O)S-(C1-C6)-alkyl, R14O2S-(C1-C6)-alkyl, hydroxycarbonyl-30 (C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1- C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, arylcarbonyloxy-(C1-C6)-alkyl, heteroarylcarbonyloxy-(C1-C6)-alkyl, heterocyclylcarbonyloxy-(C1-C6)-alkyl, aryloxy-(C1-C6)-alkyl, heteroaryloxy-(C1-C6)-alkyl, 35 (C1-C6)-Alkoxycarbonyl and wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a BCS241005-Abroad STR 17 Group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1- C8)-Alkylsulfonyl, R14for (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, 5 (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)- Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1- C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl-(C1- C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Amino, Bis- [(C1-C6)-alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino,10 Aryl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1-C6)- alkyl]amino; N-acetidinyl, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, wherein the last twelve mentioned residues are only bonded to sulfonyl groups and wherein heterocyclyl carries n oxo groups, and wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, 15 Halogen, Cyano, Carbamoyl and (C1-C8)-Alkylsulfonyl, R15and R16independently of each other for (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, Aryl, Heteroaryl, Heterocyclyl and where Heterocyclyl carries n oxo groups, or 20 R15and R16with the carbon atom to which they are bonded, they form a fully saturated monocyclic carbocycle of 3 to 7 members, R17, R18, R19and R20independently of each other for hydrogen, halogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy, (C1-C6)-Haloalkoxy, (C3-C6)-Cycloalkyl, (C1-C6)-haloalkyl, where 25 and n represent 0, 1, or 2. 30 Particularly preferred subject matter of the invention is compounds of the general formula (I), wherein M represents the groups BCS241005-Abroad STR 18 ``` M-1 M-2 M-3stands, where the dashed line marks the point of connection to the rest of formula (I), 5 R1R stands for aryl or heteroaryl, wherein the aryl or heteroaryl group may be further substituted by 1, 2 or 3 independently chosen substituents bonded to ring carbon atoms4, 10 and where, if applicable, two adjacent substituents R4with the ring carbon atoms to which they are bonded, can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, 15 or R1stands for a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen and sulfur, and wherein the heterocyclyl residue is optionally substituted by one, two or three substituents, which are independently chosen from 20 a group (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Cycloalkyl, (C1-C4)-Alkoxy, (C1-C4)- Alkoxy-(C1-C4)-alkyl, (C2-C4)-Alkenyl, (C1-C4)-Haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl; R2stands for hydrogen, 25 R3for (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, R13O-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl stands, R4for Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorosulfanyl, Nitro, Aryldiazo, 30 NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1C5)-alkyl, OSO2-(C1C5)-haloalkyl, OSO2-(C3C6)-cycloalkyl, C(O)OR13, C(O)R13, C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, R13S-(C1- BCS241005-Abroad STR 19 C6)-alkyl, R13(O)C-(C1-C6)-alkyl, (C1-C6)-Alkyl, cyano-(C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2- C6)-Alkynyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)- Haloalkoxy-(C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, 5 (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-haloalkyl, (C4-C6)-Cycloalkenyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-haloalkyl, heterocyclyl, heterocyclyl-(C1-C6)- alkyl, aryl-(C1-C6)-alkynyl, heteroaryl-(C1-C6)-alkynyl, heterocyclyl-(C1-C6)-alkynyl, Tris-[(C1- C6)-alkyl]silyl-(C2-C6)-alkynyl, Bis-[(C1-C6)-alkyl](aryl)silyl-(C2-C6)-alkynyl, Bis-aryl[(C1-C6)- alkyl]silyl-(C2-C6)-alkynyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkynyl, aryl-(C2-C6)-alkenyl, 10 Heteroaryl-(C2-C6)-alkenyl, heterocyclyl-(C2-C6)-alkenyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkenyl, cyano-(C3-C6)-Cycloalkylaminosulfonylamino, Tris-[(C1-C6)-alkyl]silyl, Bis-[(C1-C6)-alkyl](aryl)silyl, bis-aryl[(C1-C6)-alkyl]silyl and wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl 15 and (C1-C8)-Alkylsulfonyl and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, R5, R6stand for hydrogen, 20 R7for hydrogen, halogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy, (C1-C6)-Haloalkoxy, (C3-C6)- Cycloalkyl, (C1-C6)-Haloalkyl stands for, Q for hydroxy or a residue of the following formulas ... Q-1 Q-2 stands25 R8for hydrogen, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, heteroaryl, (C2-C6)-Alkynyl, (C2-C6)-Alkenyl, C(O)R13, C(O)OR13, (C1-C6)-Alkoxy-(C1-C6)-alkyl stands, R9for hydrogen or (C1-C6)-Alkyl stands, 30 R10for hydrogen, halogen, cyano, NO2, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Halocycloalkyl-(C1-C6)- alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, Aryl, Aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1- C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R11R12N-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, ` ... BCS241005-Abroad STR 20 Cyano-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- carbonyloxy-(C1-C6)-alkyl, arylcarbonyloxy-(C1-C6)-alkyl, heteroarylcarbonyloxy-(C1-C6)-alkyl, heterocyclylcarbonyloxy-(C1-C6)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- C6)-alkyl, R14(O)S-(C1-C6)-alkyl, R14O2S-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, 5 Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, Tris- [(C1-C6)-Alkyl]silyl, bis-hydroxyboryl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkoxy]boryl-(C1-C6)-alkyl, tetramethyl-1,3,2-dioxaborolan-2-yl, tetramethyl-1,3,2-dioxaborolan-2-yl-(C1-C6)-alkyl, Nitro-(C1-C6)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1-C6)-alkyl, R11R12N(O)C- (C1-C6)-alkyl, Bis-(C1-C6)-alkoxy-(C1-C6)-alkyl and wherein heterocyclyl carries n oxo groups 10, or R8and R10with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 15 R11and R12are the same or different and independent of each other for hydrogen, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4- C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-20°C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C6)- Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-amino-carbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-25 alkoxycarbonyl, heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)-alkynyloxycarbonyl, heterocyclyl-(C1-C6)-alkyl and where heterocyclyl carries n oxo groups, or R11and R12with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, R13for hydrogen, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, 35 (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)- ``` BCS241005-Ausland STR 21 alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, aryl, aryl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)- 5 alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, aryl-(C1-C6)-alkyl-amino-(C2- C6)-alkyl, R14S-(C1C6)-alkyl, R14(O)S-(C1C6)-alkyl, R14O2S-(C1-C6)-alkyl, hydroxycarbonyl- (C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1- C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, 10 arylcarbonyloxy-(C1-C6)-alkyl, heteroarylcarbonyloxy-(C1-C6)-alkyl, heterocyclylcarbonyloxy-(C1-C6)-alkyl, aryloxy-(C1-C6)-alkyl, heteroaryloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl and wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1-15°C8)-Alkylsulfonyl, R14for (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)- Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-20 (C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Amino, Bis-[(C1-C6)- alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, aryl-[(C1- C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1-C6)-alkyl]amino; N-acetidinyl, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, wherein the last twelve 25 residues are only bonded to sulfonyl groups and wherein heterocyclyl carries n oxo groups, and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-Alkylsulfonyl, 30 R15and R16independently of each other for (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, Aryl, Heteroaryl, Heterocyclyl and where Heterocyclyl carries n oxo groups, or R15and R16with the carbon atom to which they are bonded, form a fully saturated monocyclic carbocycle of 3 to 7 members, 35 R17, R18, R19and R20independently of each other for hydrogen, halogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy, (C1-C8)-Haloalkoxy, (C3-C6)-Cycloalkyl, (C1-C6)-Haloalkyl BCS241005-Abroad STR 22 and n stands for 0, 1 or 2. 5 In particular, the preferred subject matter of the invention is compounds of the general formula (I), wherein M stands for the groups M-1 M-2 M-310, where the dashed line marks the link to the rest of formula (I), R1 for phenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2-trifluoromethylphenyl, 3-15 trifluoromethylphenyl, 4-trifluoromethylphenyl, 2-trifluoromethoxyphenyl, 3-trifluoromethoxyphenyl, 4-trifluoromethoxyphenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 3-fluorophenyl, 4-fluorophenyl, 2-fluorophenyl, 2-bromophenyl, 2-iodophenyl, 3-bromophenyl, 3-iodophenyl, 4-bromophenyl, 4-iodophenyl, 2-difluoromethylphenyl, 2-cyanophenyl, 3-difluoromethylphenyl, 3-cyanophenyl, 4-difluoromethylphenyl, 4-cyanophenyl, 20 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3,4-difluorophenyl, 2,4-difluorophenyl, 2,3-difluorophenyl, 3,5-difluorophenyl, 2,5-difluorophenyl, 2,6-difluorophenyl, 3,4-dichlorophenyl, 2,4-dichlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 2,5-dichlorophenyl, 2,6-dichlorophenyl, 3,4-dibromophenyl, 2,4-Dibromophenyl, 2,3-Dibromophenyl, 3,5-Dibromophenyl, 2,5-Dibromophenyl, 3,5-Diiodophenyl, 2,4-Diiodophenyl, 2,5-Diiodophenyl, 3,4-Diiodophenyl, 3-25 Fluoro-4-chlorophenyl, 2-Fluoro-4-chlorophenyl, 2-Fluoro-3-chlorophenyl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-chlorophenyl, 2-fluoro-6-chlorophenyl, 3-fluoro-5-bromophenyl, 3-fluoro-5-iodophenyl, 3-fluoro-4-bromophenyl, 3-fluoro-4-iodophenyl, 2-fluoro-4-trifluoromethylphenyl, 2-fluoro-4-methylphenyl, 2-fluoro-4-trifluoromethoxyphenyl, 2-fluoro-4-trifluoromethylsulfanylphenyl, 2-fluoro-4-cyanophenyl, 2-fluoro-4-methoxyphenyl, 2-fluoro-4-methoxycarbonylphenyl, 2-fluoro-4-30hydroxycarbonylphenyl, 2-fluoro-6-trifluoromethylphenyl, 2-fluoro-6-methylphenyl, 2-fluoro-6-trifluoromethoxyphenyl, 2-fluoro-6-trifluoromethylsulfanylphenyl, 2-fluoro-6-cyanophenyl, 2-fluoro-6-methoxyphenyl, 2-Fluoro-6-methoxycarbonylphenyl, 2-Fluoro-6-hydroxycarbonylphenyl, BCS241005-Abroad STR 23 3-fluoro-5-methoxycarbonylphenyl, 3-fluoro-5-hydroxycarbonylphenyl, 3-fluoro-5-cyanophenyl, 3-fluoro-5-methoxyphenyl, 3-chloro-5-methoxyphenyl, 3-bromo-5-methoxyphenyl, 3-iodo-5-methoxyphenyl, 3-chloro-4-fluorophenyl, 3-bromo-4-fluorophenyl, 3-iodo-4-fluorophenyl, 3-bromo-4-chlorophenyl, 3-iodo-4-chlorophenyl, 3-iodo-4-bromophenyl, 3-iodo-5-bromophenyl, 3-bromo-4-5-iodophenyl, 4-bromo-3-chlorophenyl, 3-chloro-4-iodophenyl, 3-Bromo-5-chlorophenyl, 3-chloro-5- iodophenyl, 3-chloro-5-cyanophenyl, 3-bromo-5-cyanophenyl, 3-iodo-5-cyanophenyl, 2-chloro-4-fluorophenyl, 2-chloro-3-fluorophenyl, 2-chloro-5-fluorophenyl, 3-chloro-5-cyclopropylphenyl, 3-(1-chlorocycloprop-1-yl)-5-chlorophenyl, 3-(1-Fluorocycloprop-1-yl)-5-chlorophenyl, 3-(1-Cyanocycloprop-1-yl)-5-chlorophenyl, 3-Cyclopropyl-5-fluorophenyl, 3-(1-Chlorocycloprop-1-yl)-10 5-fluorophenyl, 3-(1-Fluorocycloprop-1-yl)-5-fluorophenyl, 3-(1-Cyanocycloprop-1-yl)-5-fluorophenyl, 3-cyclopropyl-5-bromophenyl, 3-Cyclopropyl-5-iodophenyl, 3-(1-Chlorocycloprop-1-yl)-5-bromophenyl, 3-(1-Fluorocycloprop-1-yl)-5-bromophenyl, 3-(1-Cyanocycloprop-1-yl)-5-bromophenyl, 3-(1-Cyanocycloprop-1-yl)phenyl, 4-(1-Cyanocycloprop-1-yl)phenyl, 3-(1-Fluorocycloprop-1-yl)-5-iodophenyl, 3-(1-Fluorocycloprop-1-yl)-5-trifluoromethylphenyl, 3-(1-15 Fluorocycloprop-1-yl)-5-trifluoromethoxyphenyl, 3,4-Dimethylphenyl, 2,4-Dimethylphenyl, 2,3-Dimethylphenyl, 2,5-Dimethylphenyl, 2,6-Dimethylphenyl, 3-Fluoro-4-methylphenyl, 3-fluoro-5-methoxyphenyl, 3-fluoro-4-methoxyphenyl, 3-fluoro-5-methylphenyl, 3,5-dimethylphenyl, 3,5-bis(trifluoromethyl)phenyl, 2,5-bis(trifluoromethyl)phenyl, 2,4-bis(trifluoromethyl)phenyl, 2,6-bis(trifluoromethyl)phenyl, 2,3-bis(trifluoromethyl)phenyl, 3,5-bis(difluoromethyl)phenyl, 3,4-20 bis(trifluoromethyl)phenyl, 3,4-bis(difluoromethyl)phenyl, 2-trifluoromethyl-4-fluorophenyl, 3-fluoro-5-trifluoromethylphenyl, 3-chloro-5-trifluoromethylphenyl, 3-bromo-5-trifluoromethylphenyl, 3-iodo-5-trifluoromethylphenyl, 3-trifluoromethyl-4-iodophenyl, 3-Trifluoromethyl-4-bromophenyl, 3- Trifluoromethyl-4-trifluoromethoxyphenyl, 3-trifluoromethyl-4-difluoromethoxyphenyl, 3-trifluoromethyl-4-cyanophenyl, 3-trifluoromethyl-4-methylphenyl, 3-trifluoromethyl-4-25fluorophenyl, 3-bromo-4-trifluoromethylphenyl, 3-iodo-4-trifluoromethylphenyl, 3-methoxy-5-trifluoromethylphenyl, 3-Methyl-5-trifluoromethylphenyl, 3-chloro-5-methylphenyl, 3-bromo-5-methylphenyl, 3-iodo-5-methylphenyl, 3-difluoromethoxy-5-trifluoromethylphenyl, 3-difluoromethoxy-4-trifluoromethylphenyl, 3-difluoromethoxy-5-trifluoromethoxyphenyl, 3-difluoromethoxy-4-trifluoromethoxyphenyl, 3-difluoromethoxyphenyl, 3-Chloro-5-30 difluoromethoxyphenyl, 3-Chloro-4-difluoromethoxyphenyl, 3-Difluoromethoxy-4-chlorophenyl, 3-Bromo-5-difluoromethoxyphenyl, 3-Bromo-4-difluoromethoxyphenyl, 3-Difluoromethoxy-4-bromophenyl, 3-Fluoro-5-difluoromethoxyphenyl, 3-Fluoro-4-difluoromethoxyphenyl, 3-Difluoromethoxy-4-fluorophenyl, 3,5-bis(difluoromethoxy)phenyl, 3-trifluoromethoxy-5-trifluoromethylphenyl, 4-chloro-3-trifluoromethoxyphenyl, 3-cyano-5-trifluoromethylphenyl, 3-35 chloro-5-prop-2-ylphenyl, 3-chloro-5-ethylphenyl, 3-prop-2-yl-5-trifluoromethylphenyl, 3-ethyl-5-trifluoromethylphenyl, 3-Cyclopropyl-5-trifluoromethylphenyl, 3-(1-Chlorycloprop-1-yl)-5-trifluoromethylphenyl, 3-(1-Fluorycloprop-1-yl)-5-trifluoromethylphenyl, 3-(1-Cyanoycloprop-1- BCS241005-Foreign STR 24 yl)-5-trifluoromethylphenyl, 2-chloro-5-trifluoromethylphenyl, 2-chloro-4-trifluoromethylphenyl, 3-chloro-4-trifluoromethylphenyl, 2-chloro-6-trifluoromethylphenyl, 2-trifluoromethyl-4-chlorophenyl, 3-trifluoromethyl-4-chlorophenyl, 2,3,4-trifluorophenyl, 2,3,5-trifluorophenyl, 3,4,5-trifluorophenyl, 2,4,5-trifluorophenyl, 2,3,6-trifluorophenyl, 2,4,6-trifluorophenyl, 3,4,5-5-trichlorophenyl, 3-bromo-4,5-dichlorophenyl, 3-fluoro-4,5-dichlorophenyl, 4-bromo-3,5-dichlorophenyl, 3,4-dichloro-5-trifluoromethylphenyl, 3,4-Dichloro-5-trifluoromethoxyphenyl, 2-fluoro-3-methoxy-4-fluorophenyl, 2,4,6-trimethylphenyl, 3,4,5-trimethylphenyl, 2-fluoro-3-methylphenyl, 2-fluoro-6-methylphenyl, 2-chloro-4,5-difluorophenyl, 2-chloro-4-fluoro-5-nitrophenyl, 2-Fluoro-4-nitrophenyl, 2,4-Difluoro-3-chlorophenyl, 2-Chloro-3,6-difluorophenyl, 2,3-10 Dichloro-6-fluorophenyl, 2-Chloro-4-cyanophenyl, 2-Ethyl-4,6-dimethylphenyl, 2-Fluoro-6-ethoxycarbonylphenyl, 2-Fluoro-6-isopropyloxyphenyl, 2,6-Difluoro-3-methylphenyl, 2,6-Dichloro-3-methylphenyl, Pyridin-2-yl, Pyridin-3-yl, 2-Fluoropyridin-3-yl, 2-Chloropyridin-3-yl, 2,4-Difluoropyridin-3-yl, 2,4-Dichloropyridin-3-yl, 2,6-Difluoropyridin-3-yl, 2,6-Dichloropyridin-3-yl, 3,4-Difluoropyridin-2-yl, 3,4-Dichloropyridin-2-yl, 3,5-Difluoropyridin-2-yl, 3,5-Dichloropyridin-2-15yl, 5-Chloropyridin-2-yl, 6-Chloropyridin-2-yl, 5-Fluoropyridin-2-yl, 6-Fluoropyridin-2-yl, 5,6-Difluoropyridin-2-yl, 5,6-Dichloropyridin-2-yl, 4,6-Difluoropyridin-2-yl, 4,6-Dichloropyridin-2-yl, 2,5-Difluoropyridin-3-yl, 2,5-Dichloropyridin-3-yl, 4-Fluoropyridin-3-yl, 4-Chloropyridin-3-yl, 5-Chloropyridin-3-yl, 5-Bromopyridin-3-yl, 4-Trifluoromethylpyridin-3-yl, 4-Fluoropyridin-2-yl, 4-Chloropyridin-2-yl, 4-Methylpyridin-2-yl, 4-Trifluoromethylpyridin-2-yl, 4-Methoxypyridin-2-yl,20 4-Trifluoromethoxypyridin-2-yl, 5-Trifluoromethylpyridin-3-yl, 5-Trifluoromethoxypyridin-3-yl, 5-Methoxypyridin-3-yl, 6-Chloropyridin-3-yl, 6-Bromopyridin-3-yl, 6-Trifluoromethylpyridin-3-yl, 2-Trifluoromethylpyridin-3-yl, 3-Fluoro-5-trifluoromethoxyphenyl, 3-Chloro-5-trifluoromethoxyphenyl, 3-Bromo-5-trifluoromethoxyphenyl, 3-iodo-5-trifluoromethoxyphenyl, 3-methyl-5-trifluoromethoxyphenyl, 3-cyano-5-trifluoromethoxyphenyl, 3-(Prop-2-yl)-5-25 trifluoromethoxyphenyl, 3-(Prop-1-yl)-5-trifluoromethoxyphenyl, 3-(But-1-yl)-5-trifluoromethoxyphenyl, 3-(1,1-Dimethyleth-1-yl)-5-trifluoromethoxyphenyl, 3-Vinyl-5-trifluoromethoxyphenyl, 3-(Prop-1-en-2-yl)-5-trifluoromethoxyphenyl, 3-(Prop-1-en-1-yl)-5-trifluoromethoxyphenyl, 3-(1-Methylprop-1-en-1-yl)-5-trifluoromethoxyphenyl, 3-Ethyl-5-trifluoromethoxyphenyl, 3-cyclopropyl-5-trifluoromethoxyphenyl, 3-cyclobutyl-5-30 trifluoromethoxyphenyl, 3-cyclopentyl-5-trifluoromethoxyphenyl, 3-cyclopent-1-en-1-yl-5-trifluoromethoxyphenyl, 3-trimethylsilyl-5-trifluoromethoxyphenyl, 3-(1-Methylprop-1-yl)-5-trifluoromethoxyphenyl, 3-(1-Methylprop-2-yl)-5-trifluoromethoxyphenyl, 3-(1-Chlorycloprop-1-yl)-5-trifluoromethoxyphenyl, 3-(1-Fluorycloprop-1-yl)-5-trifluoromethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-5-trifluoromethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-4-35 trifluoromethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-5-trifluoromethylphenyl, 3-(1-Cyanocycloprop-1-yl)-4-trifluoromethylphenyl, 3,5-bis(trifluoromethoxy)phenyl, 3,4-bis(trifluoromethoxy)phenyl, 3-methoxymethyl-5-trifluoromethoxyphenyl, 3,5-Dichloropyridine-4- BCS241005-Foreign STR 25yl, 3,5-Difluoropyridin-4-yl, 3,5-Dibromopyridin-4-yl, 3,5-Dimethylpyridin-4-yl, 3,5-bis(trifluoromethyl)pyridin-4-yl, 2,6-Dichloropyridin-4-yl, 2,6-Difluoropyridin-4-yl, 2,6-dibromopyridin-4-yl, 2,6-dimethylpyridin-4-yl, 2,6-bis(trifluoromethyl)pyridin-4-yl, 2-chloropyridin-4-yl, 2-trifluoromethylpyridin-4-yl, 3-chloropyridin-4-yl, 3-trifluoromethylpyridin-5 4-yl, 3-Chloro-5-(pentafluoro-λ⁶-sulfanyl)phenyl, 3-Fluoro-5-(pentafluoro-λ⁶-sulfanyl)phenyl, 3-Bromo-5-(pentafluoro-λ⁶-sulfanyl)phenyl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 2- Methoxy-1,3-benzothiazol-5-yl, 2-methyl-1,3-benzothiazol-5-yl, 2-chloro-1,3-benzothiazol-5-yl, naphth-2-yl, naphth-1-yl, 8-bromonaphth-2-yl, 7-bromonaphth-2-yl, 6-bromonaphth-2-yl, 5- Bromonaphth-2-yl, 3-chloro-5-methylsulfonylphenyl, 3-Chloro-4-(methylsulfonyl)phenyl, 3-bromo-10 5-methylsulfonylphenyl, 3-bromo-4-methylsulfonylphenyl, 3-methylsulfonyl-4-trifluoromethylphenyl, 3-(methylsulfonyl)-4-chlorophenyl, 4-bromo-3-methylsulfonylphenyl, 3-chloro-5-(ethylsulfonyl)phenyl, 3-Chloro-5-(prop-2-ylsulfonyl)phenyl, 3-Chloro-5-(cyclopropylsulfonyl)phenyl, 3-Methylsulfonyl-5-trifluoromethylphenyl, 3-Methylsulfonyl-5-trifluoromethoxyphenyl, 3-Methylsulfonyl-5-(1H-pyrazol-1-yl)phenyl, 3-Methylsulfonyl-5-(1H-15 1,2,4-triazol-1-yl)phenyl, 3-ethylsulfonyl-5-trifluoromethoxyphenyl, 3-Ethylsulfinyl-5-trifluoromethoxyphenyl, 3-Ethylsulfanyl-5-trifluoromethoxyphenyl, 3-Chloro-5-(methylsulfinyl)phenyl, 3-Chloro-5-(ethylsulfinyl)phenyl, 3-Chloro-5-(prop-2-ylsulfinyl)phenyl, 3-Chloro-5-(cyclopropylsulfinyl)phenyl, 3-(Methylsulfinyl)-5-trifluoromethylphenyl, 3-(Methylsulfinyl)-5-trifluoromethoxyphenyl, 3-(Methylsulfinyl)-5-(1H-pyrazol-1-yl)phenyl, 3-20(Methylsulfinyl)-5-(1H-1,2,4-triazol-1-yl)phenyl, 3-Chloro-5-(methylsulfanyl)phenyl, 3-chloro-5-(ethylsulfanyl)phenyl, 3-Chloro-5-(prop-2-ylsulfanyl)phenyl, 3-Chloro-5-(cyclopropylsulfanyl)phenyl, 3-(Methylsulfanyl)-5-trifluoromethylphenyl, 3-(Methylsulfanyl)-5-trifluoromethoxyphenyl, 3-(Methylsulfanyl)-5-(1H-pyrazol-1-yl)phenyl, 3-Methylsulfanyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2,3-dihydro-1,4-benzodioxin-6-yl, 1,1,4,4-tetraoxido-2,3-dihydro-25 1,4-benzodithiin-6-yl, 1,1,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,4,4-Trioxido-2,3- dihydro-1,4-benzodithiin-6-yl, 1,4-dioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 2,3-dihydro-1,4-benzodithiin-6-yl, 1,1,3,3-tetraoxido-1,3-benzodithiol-5-yl, 1,1,3-trioxido-1,3-benzodithiol-5-yl, 1,3-dioxido-1,3-benzodithiol-5-yl, 1,3-benzodithiol-5-yl, 2,3-dihydro-1,4-benzoxathiin-6-yl, 2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-dioxido-2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-dioxido-30 2,3-dihydro-1,4-benzoxathiin-6-yl, 3,3-dioxido-1,3-benzoxathiol-5-yl, 3-oxido-1,3-benzoxathiol-5-yl, 1,3-benzoxathiol-5-yl, 3,3-dioxido-1,3-benzoxathiol-6-yl, 3-oxido-1,3- benzoxathiol-6-yl, 1,3-benzoxathiol-6-yl, 3,5-bis(methylsulfonyl)phenyl, 3,4-bis(methylsulfonyl)phenyl, 3,5-bis(methylsulfanyl)phenyl, 3,4-bis(methylsulfanyl)phenyl, 3-(4-chloro-1H-pyrazol-1-yl)phenyl, 3-(4-Bromo-1H-pyrazol-1-yl)phenyl, 3-(4-Iodo-1H-pyrazol-1-35yl)phenyl, 3-(4-methyl-1H-pyrazol-1-yl)phenyl, 3-(4-trifluoromethyl-1H-pyrazol-1-yl)phenyl, 3-(1H-pyrazol-1-yl)phenyl, 3-(1H-pyrazol-1-yl)-5-chlorophenyl, 3-(1H-pyrazol-1-yl)-5-trifluoromethylphenyl, 3-(1H-pyrazol-1-yl)-5-trifluoromethoxyphenyl, 1,3-benzodioxol-5-yl, 7- BCS241005-Foreign STR 26 chloro-1,3-benzodioxol-5-yl, 6-chloro-1,3-benzodioxol-5-yl, 5-methylpyrazin-2-yl, 5-trifluoromethylpyrazin-2-yl, 5-fluoropyrazin-2-yl, 5-chloropyrazin-2-yl, 5-Bromopyrazin-2-yl, Pyrazin-2-yl, Pyridazin-4-yl, Pyridazin-3-yl, 2-Methylpyrimidin-5-yl, Pyrimidin-5-yl, 3-Nitro-5-methoxyphenyl, 3-Nitro-4-methoxyphenyl, 3-Chloro-5-nitrophenyl, 3-Chloro-4-nitrophenyl, 3-5 Nitro-4-chlorophenyl, 2-nitro-5-trifluoromethoxyphenyl, 3-Nitro-5-trifluoromethylphenyl, 3-nitro-4-trifluoromethoxyphenyl, 3-trifluoromethyl-4-nitrophenyl, 3-nitro-5-trifluoromethoxyphenyl, 3-nitrophenyl, 3-phenyl-5-trifluoromethylphenyl, 3-methoxycarbonylphenyl-5-trifluoromethylphenyl, 3,5-bis-(trifluoromethanesulfonyl)phenyl, 3- Fluoro-5-[(trifluoromethyl)sulfonyl]phenyl, 3-chloro-5-[(trifluoromethyl)sulfonyl]phenyl, 3-bromo-5-10[(trifluoromethyl)sulfonyl]phenyl, 3-[(1-cyanocycloprop-1-yl)-1-sulfonyl]-5-trifluoromethoxyphenyl, 3-(1-Carbamoylcyclopropyl)-5-trifluoromethylsulfonylphenyl, 3-(2-cyanopropyl-2-sulfonyl)-5-trifluoromethoxyphenyl, 3-(1-Cyano-1-methyleth-1-yl)-5-trifluoromethylsulfonylphenyl, 3-(1-Cyanocycloprop-1-yl)-5-(trifluoromethylsulfonyl)phenyl, 3-(1-Cyano-1-methyleth-1-yl)-5-trifluoromethylphenyl, 3-(1-Cyano-1-methyl-ethyl)-5-15 trifluoromethoxyphenyl, 3-[(Difluoromethyl)sulfonyl]-5-trifluoromethoxyphenyl, 3,5-bis-(difluoromethylsulfonyl)phenyl, 3-(1-methylsulfonylcyclopropyl)-5-trifluoromethoxyphenyl, 3-cyclopropylsulfamoyl-5-trifluoromethoxyphenyl, 3-methylsulfamoyl-5-trifluoromethoxyphenyl, 3-sulfamoyl-5-trifluoromethoxyphenyl, 3-(1-methyl-1-methylsulfonylethyl)-5- trifluoromethoxyphenyl, 3-bromo-5-[bromo(difluoro)methyl]phenyl, 3-chloro-5-20[chloro(difluoro)methyl]phenyl, 3-chloro-5-(2-chloro-1,1,2,2-tetrafluoroethoxyphenyl, 3-(1-methylsulfonylcyclopropyl)-5-trifluoromethylphenyl, 3-chloro-5-[1-(trifluoromethyl)cyclopropyl]phenyl, 3-Bromo-5-[1-(trifluoromethyl)cyclopropyl]phenyl, 3-bromo-5-(2,2-dichlorocyclopropyl)phenyl, 3-chloro-5-(2,2-dichlorocyclopropyl)phenyl, 3-fluoro-5-(2,2-dichlorocyclopropyl)phenyl, 3-cyclopropylsulfonyl-5-trifluoromethoxyphenyl, 3-25 Cyclobutylsulfonyl-5-trifluoromethoxyphenyl, 3-[(Prop-1-yl)sulfonyl]-5-trifluoromethoxyphenyl, 3-[Prop-2-ylsulfonyl]-5-trifluoromethoxyphenyl, 3-[1-methyl-1-(methylsulfonyl)ethyl]-5-trifluoromethylphenyl, 3-methylsulfonyl-5-(1,1,2,2-tetrafluorethoxy)phenyl, 3-Bromo-5-(1,1,2,2-tetrafluorethoxy)phenyl, 3,5-bis-(1,1,2,2-tetrafluorethoxy)phenyl, 3-(trifluoromethoxy)-5-vinylphenyl, 3-formyl-5-trifluoromethoxyphenyl, 3-[(Z)-(methoxyimino)methyl]-5-30 trifluoromethoxyphenyl, 3-[(E)-(methoxyimino)methyl]-5-trifluoromethoxyphenyl, 3-[(Z)- (ethoxyimino)methyl]-5-trifluoromethoxyphenyl, 3-[(E)-(ethoxyimino)methyl]-5-trifluoromethoxyphenyl, 3-[(Z)-(hydroxyimino)methyl]-5-trifluoromethoxyphenyl, 3-[(E)-(hydroxyimino)methyl]-5-trifluoromethoxyphenyl, 2-(2,2-difluorocyclopropyl)phenyl, 2-(2,2- Dibromocyclopropyl)phenyl, 2-(2-Bromo-2-Methylcyclopropyl)phenyl, 2-(2-35 Methylenecyclopropyl)phenyl, 2-[1,1'-Bi(cyclopropyl)-1-yl]phenyl, 2-(Spiro[2.2]pentan-1-yl)phenyl, 3-(2,2-Difluorocyclopropyl)phenyl, 3-(2-Bromo-2-Methylcyclopropyl)phenyl, 3-(2-methylenecyclopropyl)phenyl, 3-[1,1'-Bi(cyclopropyl)-1-yl]phenyl, 3-(Spiro[2.2]pentane-1- BCS241005-Foreign STR 27 yl)phenyl, 3-chloro-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-bromo-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3,5-dimethyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Trifluoromethyl-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-(5-amino-2-chloro-4-fluorophenyl)-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-(5-nitro-2-chloro-4-fluorophenyl)-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-[2-Chloro-5-(3.5-5 dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorophenyl]-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6- dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{2-bromo-4-fluoro- 5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5- dihydro-1,2-oxazol-5-yl, 3-{2-Iodo-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-10 dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-amino-2,6- dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-chloro-4-fluorophenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-amino-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin- 1(2H)-yl]-2-bromo-4-fluorophenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-iodo-4-fluorophenyl}-5-methyl-4,5-15 dihydro-1,2-oxazol-5-yl, 2-{5-[3-Amino-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-chloro-4-fluorophenyl}-1,3-thiazol-5-yl, 2-{5-[3-amino-2,6-dioxo-4-(trifluoromethyl)- 3,6-dihydropyrimidin-1(2H)-yl]-2-bromo-4-fluorophenyl}-1,3-thiazol-5-yl, 2-{5-[3-amino-2,6- dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-iodo-4-fluorophenyl}-1,3-thiazol-5-yl, 2-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-20 yl]phenyl}-1,3-thiazol-5-yl, 2-{2-bromo-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 2-{2-iodo-4-fluoro-5-[3-methyl-2,6-dioxo-4- (trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 2-[2-chloro-5-(3,5-dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorophenyl]-1,3-thiazol-5-yl, 1,3- Thiazol-5-yl, 1,3-thiazol-4-yl, 2-chloro-1,3-thiazol-5-yl, 2-chloro-1,3-thiazol-4-yl, 2-methyl-1,3-25thiazol-5-yl, 2-methyl-1,3-thiazol-4-yl, 4-methyl-1,3-thiazol-2-yl, 5-Methyl-1,3-thiazol-2-yl, thien-2-yl, Thien-3-yl, 5-chlorothien-2-yl, 5-bromothien-2-yl, 4-chlorothien-2-yl, 4-bromothien-2-yl, 3-chlorothien-2-yl, 3-bromothien-2-yl, 4,5-dichlorothien-2-yl, 4,5-dibromothien-2-yl, 3,4- Dichlorothien-2-yl, 3,4-dibromothien-2-yl, 4-bromo-3-methoxythien-2-yl, 4-bromo-3-methylthien-2-yl, 5-(1-cyanocycloprop-1-yl)thien-2-yl, 3-trifluoromethylthien-2-yl, 4-trifluoromethylthien-2-30yl, 5-trifluoromethylthien-2-yl, 3-Trifluoromethoxythien-2-yl, 4-Trifluoromethoxythien-2-yl, 3-Difluoromethoxythien-2-yl, 4-Difluoromethoxythien-2-yl, 3-Difluoromethoxy-5-methylthien-2-yl, 4-Chlorothien-3-yl, 5-Chlorothien-3-yl, 2-Chlorothien-3-yl, 4-Bromothien-3-yl, 4-Methylthien-3-yl, 2,4-Dichlorothien-3-yl, 2,5-Dichlorothien-3-yl, 1-Methyl-1H-pyrazol-5-yl, 1-Ethyl-1H-pyrazol-5-yl, 4-Chloro-1,3-Dimethyl-1H-pyrazol-5-yl, 1,3-Dimethyl-1H-pyrazol-5-yl, 4-Chloro-1H-pyrazol-35 5-yl, 1-Methyl-1H-pyrazol-4-yl, 4-Methyl-1,2,3-thiadiazol-5-yl, 3-Methyl-1,2-oxazol-5-yl, 4-Methyl-1,2-oxazol-5-yl, 5-Methyl-1,2-oxazol-3-yl, 4-Methyl-1,3-oxazol-5-yl, 4,5-Dichloro-1,2-thiazol-3-yl, 1,2-thiazol-3-yl, 1,2-thiazol-5-yl, 4-chloro-1,2-thiazol-5-yl, 3-chloro-1,2-thiazol-5-yl BCS241005-Foreign STR 28 yl, 3,4-dichloro-1,2-thiazol-5-yl, 3-chloro-4-cyano-1,2-thiazol-5-yl, 1,2-benzoxazol-3-yl, 1,2-benzothiazol-3-y1, 7-chloro-1,2-benzothiazol-3-yl, 3-Trimethylsilyl-5-trifluoromethylphenyl, 3,5-bis(Trimethylsilyl)phenyl, 3-(1,1-Dimethyleth-1-yl)-5-trifluoromethyl, 3-Methylsulfonyl-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-Bromo-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-Chloro-5-(1,1,2,2-5 tetrafluoroethyl)phenyl 3-fluoro-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-bromo-5-cyclopropylsulfonylphenyl, 3-cyclopropylsulfonyl-5-trimethylsilylphenyl, 3-cyclopropylsulfonyl-5-trifluoromethylphenyl, 3-[cyclopropyl(difluoro)methyl]-5-trifluoromethoxyphenyl, 3-[Cyclopropyl(difluoro)methyl]-5-trifluoromethylphenyl, 3-bromo-5-[cyclopropyl(difluoro)methyl]phenyl, 3-chloro-5-[cyclopropyl(difluoro)methyl]phenyl, 3-fluoro-5-10[cyclopropyl(difluoro)methyl]phenyl, 3-[cyclopropyl(difluoro)methyl]-5-methylsulfonylphenyl, 3- [Chloro(difluoro)methyl]-5-methylsulfonylphenyl, 3,5-bis[chloro(difluoro)methyl]phenyl, 3-(1,1- Difluoroeth-1-yl)-5-trifluoromethylphenyl, 3-(1,1-Difluoroeth-1-yl)-5-trifluoromethoxyphenyl, 3-(1,1-Difluoroeth-1-yl)-5-chlorophenyl, 3-(1,1-Difluoroeth-1-yl)-5-bromophenyl, 3-trifluoromethylsulfanylphenyl, 3-trifluoromethylsulfanyl-5-chlorophenyl, 3-trifluoromethylsulfanyl-15 5-fluorophenyl, 3-trifluoromethylsulfanyl-5-bromophenyl, 3-trifluoromethylsulfanyl-4-chlorophenyl, 3-trifluoromethylsulfanyl-4-fluorophenyl, 3-trifluoromethylsulfanyl-4-bromophenyl, 3-(4-methoxycarbonylphenyl)-5-trifluoromethylphenyl, 3-(oxetan-3-yl)phenyl, 3-(3-Fluoroxetan-3-yl)phenyl, 3-(Oxetan-3-yl)-5-trifluoromethoxyphenyl, 3-(3-Fluoroxetan-3-yl)-5-trifluoromethylphenyl, 4-Trifluoromethylsulfanylpyridin-3-yl, 5-Trifluoromethylsulfanylpyridin-3-20yl, 6-Trifluoromethylsulfanylpyridin-3-yl, 3-(Methylsulfonyloxy)phenyl, 3-(Methylsulfonyloxy)-5-chlorophenyl, 3-(Methylsulfonyloxy)-5-trifluoromethylphenyl, 3-(Methylsulfonyloxy)-5-trifluoromethoxyphenyl, 3-(Trifluoromethylsulfonyloxy)phenyl, 3-(Trifluoromethylsulfonyloxy)-5-chlorophenyl, 3-(Trifluoromethylsulfonyloxy)-5-trifluoromethylphenyl, 3- (Trifluoromethylsulfonyloxy)-5-trifluoromethoxyphenyl, 4-(Methylsulfonyloxy)phenyl, 3-25 (Methylsulfonyloxy)-4-chlorophenyl, 3-(Methylsulfonyloxy)-4-trifluoromethylphenyl, 3-(Methylsulfonyloxy)-4-trifluoromethoxyphenyl, 3-chloro-4-(Methylsulfonyloxy)phenyl, 3- Trifluoromethyl-4-(methylsulfonyloxy)phenyl, 3-trifluoromethoxy-4-(methylsulfonyloxy)phenyl, 3-(3-methyl-1,2,4-oxadiazol-5-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl, 4-Chloro-3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl, 3-(5-methyl-1,3,4-30 oxadiazol-2-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl, 4-chloro-3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl, 3-(5-methyl-1,2,4-oxadiazol-3-yl)-5-(trifluoromethoxy)phenyl, 3-Chloro-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl, 4-Chloro-3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl, 3-(2,5-Dioxoimidazolidin-4-yl)-5-(trifluoromethoxy)phenyl, 3-Chloro-5-(2,5-dioxoimidazolidin-4-yl)phenyl, 4-Chloro-3-(2,5-dioxoimidazolidin-4-yl)phenyl,35 3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-5-(trifluoromethoxy)phenyl, 3-Chloro-5-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)phenyl, 4-Chloro-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)phenyl, 3-(5-oxo-4,5-dihydro-1H-pyrazol-3-yl)-5-(trifluoromethoxy)phenyl, 3-Chloro-5-(5- BCS241005-Ausland STR 29 oxo-4,5-dihydro-1H-pyrazol-3-yl)phenyl, 4-chloro-3-(5-oxo-4,5-dihydro-1H-pyrazol-3-yl)phenyl, 3-(1,3-thiazol-2-yl)-5-(trifluoromethoxy)phenyl, 3-Chloro-5-(1,3-thiazol-2-yl)phenyl, 4-Chloro-3-(1,3-thiazol-2-yl)phenyl, 3-(2-Methyl-1,3-thiazol-5-yl)-5-(trifluoromethoxy)phenyl, 3-Chloro-5-(2-methyl-1,3-thiazol-5-yl)phenyl, 4-Chloro-3-(2-methyl-1,3-thiazol-5-yl)phenyl, 3-(1,3-5 Oxazol-2-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(1,3-oxazol-2-yl)phenyl, 4-chloro-3-(1,3-oxazol-2-yl)phenyl, 3-(2-methyl-1,3-oxazol-5-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(2- methyl-1,3-oxazol-5-yl)phenyl, 4-chloro-3-(2-methyl-1,3-oxazol-5-yl)phenyl, 3-(2-oxoazetidin-1-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(2-oxoazetidin-1-yl)phenyl, 4-chloro-3-(2-oxoazetidin-1-yl)phenyl, 3-(2-oxopyrrolidin-1-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(2-10 oxopyrrolidin-1-yl)phenyl, 4-chloro-3-(2-oxopyrrolidin-1-yl)phenyl, 3-(2,4-dioxoimidazolidin-1-yl)-5-(trifluoromethoxy)phenyl, 3-Chloro-5-(2,4-dioxoimidazolidin-1-yl)phenyl, 4-Chloro-3-(2,4-dioxoimidazolidin-1-yl)phenyl, 3-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5-(trifluoromethoxy)phenyl, 3-Chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl, 4-Chloro-3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl, 3-(6-methyl-2,4-dioxo-3,4-15 dihydropyrimidin-1(2H)-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(6-methyl-2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)phenyl, 4-chloro-3-(6-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl, 4,5-dichloro-2-hydroxyphenyl, 3,4-dichloro-5-hydroxyphenyl, 3,4-dichloro-2-hydroxyphenyl, 1,3-benzoxathiol-6-yl, 3-methylcarbonyl-5-nitrophenyl, 4,5-Dichloro-2-fluorophenyl, 3,4-Dichloro-2-fluorophenyl, 3,4-Dichloro-5-fluorophenyl, 2,2-Difluoro-1,3-20 benzodioxol-5-yl, 3-(1-Methylcycloprop-1-yl)-5-fluorophenyl, 3-(1-Methylcycloprop-1-yl)-5-chlorophenyl, 3-(1-Methylcycloprop-1-yl)-5-bromophenyl, 3-(1-Methylcycloprop-1-yl)-5-trifluoromethylphenyl, 3-(1-Methylcycloprop-1-yl)-5-trifluoromethoxyphenyl, 3-(Methylaminocarbonyl)-5-trifluoromethoxyphenyl, 3-(Ethylaminocarbonyl)-5-trifluoromethoxyphenyl, 3-(Prop-2-ylaminocarbonyl)-5-trifluoromethoxyphenyl, 3-25 (Cyclopropylaminocarbonyl)-5-trifluoromethoxyphenyl, 3-aminocarbonyl-5-trifluoromethoxyphenyl, 3-(methylaminocarbonyl)-5-trifluoromethylphenyl, 3-(ethylaminocarbonyl)-5-trifluoromethylphenyl, 3-(prop-2-ylaminocarbonyl)-5-trifluoromethylphenyl, 3-(cyclopropylaminocarbonyl)-5-trifluoromethylphenyl, 3-Aminocarbonyl-5-trifluoromethylphenyl, 3-(Methylaminocarbonyl)-5-chlorophenyl, 3-(Ethylaminocarbonyl)-5-30chlorophenyl, 3-(Prop-2-ylaminocarbonyl)-5-chlorophenyl, 3-(Cyclopropylaminocarbonyl)-5-chlorophenyl, 3-Aminocarbonyl-5-chlorophenyl, 3-Methyl-5-phenyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Methyl-4,5-dihydro-1,2-oxazol-5-yl is, R2stands for hydrogen, 35 R3 for methyl, ethyl, prop-1-yl, 1-methylethyl, but-1-yl, 1-methylprop-1-yl, 2-methylprop-1-yl, 1,1-dimethylethyl, pent-1-yl, 1-methylbut-1-yl, 2-methylbut-1-yl, 3-methylbut-1-yl, 1,1- BCS241005-Abroad STR 30 Dimethylprop-1-yl, 1,2-Dimethylprop-1-yl, 2,2-Dimethylprop-1-yl, 1-Ethylprop-1-yl, Hex-1-yl, 1-Methylpent-1-yl, 2-Methylpent-1-yl, 3-Methylpent-1-yl, 4-Methylpent-1-yl, 1-Ethylbut-1-yl, 2-Ethylbut-1-yl, 1,2-Dimethylbut-1-yl, 1,3-Dimethylbut-1-yl, 2,2-Dimethylbut-1-yl, 3,3-Dimethylbut-1-yl, Cyclopropyl, Cyclobutyl, Cyclopentyl, Cyclohexyl, Methoxymethyl, 5 Ethoxymethyl, Methoxyethyl, Ethoxyethyl, Cyclopropylmethyl, Cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, vinyl, Prop-1-en-1-yl, Prop-2-en-1-yl, But-1-en-1-yl, But-2-en-1-yl, But-3-en-1-yl, Pent-1-en-1-yl, Pent-2-en-1-yl, Pent-3-en-1-yl, Pent-4-en-1-yl, 1-Methylprop-2-en-1-yl, 2-Methylprop-2-en-1-yl, 1-Methylbut-2-en-1-yl, 2-Methylbut-2-en-1-yl, 3-Methylbut-2-en-1-yl, 1-Methylbut-3-en-1-yl, 2-Methylbut-3-en-1-yl, 3-Methylbut-3-en-1-yl, 10 1,1-Dimethylprop-2-en-1-yl, or 1,2-Dimethylprop-2-en-1-yl stands, R5, R6stand for hydrogen, R7R stands for hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, prop-1-yl, prop-2-yl, cyclopropyl, 15-cyclobutyl, methoxy, ethoxy, trifluoromethoxy, difluoromethoxy, difluoromethyl, trifluoromethyl17, R18, R19and R20independently of each other stand for hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, prop-1-yl, prop-2-yl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, prop-1-yloxy, prop-2-yloxy, trifluoromethoxy, difluoromethoxy, difluoromethyl, trifluoromethyl, and Q stands for a residue of the following formulas Q-1 to Q-500 25 BCS241005-Abroad STR 31 ``` BCS241005-Abroad STR 32 ``` 5 BCS241005-Abroad STR 33 ``` 5 BCS241005-Abroad STR 34 ``` 5 BCS241005-Abroad STR 35 ``` 5 BCS241005-Abroad STR 36 ``` 5 BCS241005-Abroad STR 37 ``` 5 BCS241005-Abroad STR 38 ``` 5 BCS241005-Abroad STR 39 ``` 5 BCS241005-Abroad STR 40 ``` 5 BCS241005-Abroad STR 41 ``` 5 BCS241005-Abroad STR 42 ``` 5 BCS241005-Abroad STR 43 ``` 5 In particular, the preferred subject matter of the invention is compounds of the general formula (I), wherein 10 M for one of the groups BCS241005-Abroad STR 44 ``` M-1 M-2 M-3stands, where the dashed line marks the point of connection to the rest of formula (I), 5 R1 for 3,4-dichlorophenyl, 3,5-dichlorophenyl, 3,4-bis(trifluoromethyl)phenyl, 3,5-bis(trifluoromethyl)phenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 3-chloro-5-trifluoromethoxyphenyl, 2-(2,2-dibromocyclopropyl)phenyl, 3-(1-cyanocycloprop-1-yl)phenyl, 3- Chloro-5-trifluoromethylphenyl, 4-chloro-3-trifluoromethoxyphenyl, 3-chloro-5-iodophenyl, 3-fluoro-10 5-iodophenyl, 3-iodo-4-chlorophenyl, 3-bromo-4-chlorophenyl, 3-fluoro-5-trifluoromethoxyphenyl, 3-bromo-5-trifluoromethoxyphenyl, 3-(Prop-2-yl)-5-trifluoromethoxyphenyl, 3-[(E)- (Methoxyimino)methyl]-5-trifluoromethoxyphenyl, 3-methyl-5-trifluoromethoxyphenyl, 3-cyano-5-trifluoromethoxyphenyl, 3-nitrophenyl, 3-nitro-5-trifluoromethylphenyl, 3-(4-methoxycarbonylphenyl)-5-trifluoromethylphenyl, 3-fluoro-5-trifluoromethylphenyl, 3-bromo-5-15 trifluoromethylphenyl, 3-Trifluoromethyl-4-chlorophenyl, 3-Chloro-4-trifluoromethylphenyl, 3,4-Diiodophenyl, 3,5-Diiodophenyl, 3-(Methylsulfanyl)-5-(1H-pyrazol-1-yl)phenyl, 4-Chloro-3-nitrophenyl, 3-Chloro-4-nitrophenyl, 5-Trifluoromethylpyridin-3-yl, 2-Trifluoromethylpyridin-4-yl, 5-fluoropyrazin-2-yl, 6-bromopyridin-3-yl, 2,6-difluoropyridin-4-yl, 3-iodo-5-trifluoromethylphenyl, 3-methylsulfonyl-5-trifluoromethylphenyl, 3,5-bis(trifluoromethoxy)phenyl, 3-difluoromethoxy-5-20 trifluoromethylphenyl, 3-Chloro-5-methylsulfonylphenyl, 3-Trifluoromethoxyphenyl, 5-Trifluoromethoxypyridin-3-yl, 3-Chloro-5-(pentafluoro-λ⁶-sulfanyl)phenyl, 3-Fluoro-5-(pentafluoro-λ⁶-sulfanyl)phenyl, 3-Bromo-5-(pentafluoro-λ⁶-sulfanyl)phenyl, 3,5-bis(methylsulfonyl)phenyl, 1,3-benzodithiol-5-yl, 2,3-dihydro-1,4-benzodithiin-6-yl, 2,6-bis(trifluoromethyl)phenyl, 3,4-dibromophenyl, 3,5-bis(methylsulfanyl)phenyl, 3,4-bis(methylsulfanyl)phenyl, 2,3-dihydro-1,4-25 benzoxathiin-7-yl, 2,3-Dihydro-1,4-benzoxathiin-6-yl, 1,3-benzoxathiol-5-yl, 1,3-benzoxathiol-6-yl, 3-chloro-5-cyclopropylphenyl, 3-chloro-5-methoxyphenyl, 3-bromo-5-methoxyphenyl, 3-(1H-pyrazol-1-yl)phenyl, 3-Bromo-5-methylsulfonylphenyl, 1,3-benzodioxol-5-yl, 3-chloro-5- nitrophenyl, 4-bromo-3-methylsulfonylphenyl, 3-nitro-4-methoxyphenyl, 2-methylpyrimidin-5-yl, 3-fluoro-4-methylphenyl, 4-methoxypyridin-2-yl, 5-methylpyrazin-2-yl, 3,4-30bis(methylsulfonyl)phenyl, 3,3-Dioxido-1,3-benzoxathiol-6-yl, 3-Oxido-1,3-benzoxathiol-6-yl, 4,4-Dioxido-2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-Dioxido-2,3-dihydro-1,4-benzoxathiin-6-yl, 3,3-Dioxido-1,3-benzoxathiol-5-yl, 1,1,3,3-Tetraoxido-1,3-benzodithiol-5-yl, 3-(4-Chloro-1H- BCS241005-Ausland STR 45 pyrazol-1-yl)phenyl, 3-(4-bromo-1H-pyrazol-1-yl)phenyl, 3-(4-iodo-1H-pyrazol-1-yl)phenyl, 6-chloro-1,3-benzodioxol-5-yl, 3-bromo-4-methylsulfonylphenyl, 6-chloropyridin-3-yl, 1,1,4,4-Tetraoxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,1,4-trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,4,4-trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 3-ethylsulfonyl-5-trifluoromethoxyphenyl, 6- 5 Fluoropyridin-2-yl, 3,5-Dibromophenyl, 4-(1-Cyanocycloprop-1-yl)phenyl, 5-Bromopyridin-3-yl, 3-Bromo-4,5-dichlorophenyl, 3,4,5-Trichlorophenyl, 3-(1-Cyanocycloprop-1-yl)-5-fluorophenyl, 3-(1-Cyanocycloprop-1-yl)-5-trifluoromethoxyphenyl, 1,3-Benzothiazol-6-yl, 3-Chloro-5-cyanophenyl, 3-Methylsulfanyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2-Methyl-1,3-benzothiazol-5-yl, 2-Chloro-1,3-benzothiazol-5-yl, Naphth-2-yl, 3-Methylsulfonyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2-Methoxy-10 1,3-benzothiazol-5-yl, 4-bromo-3-chlorophenyl, 6-bromonaphth-2-yl, 5-bromonaphth-2-yl, 1,3-benzothiazol-5-yl, 3-methylsulfonyl-5-(1H-pyrazol-1-yl)phenyl, 2,3-dichlorophenyl, 2,4- Dichlorophenyl, 2,5-dichlorophenyl, 2,4-dibromophenyl, 3,4-difluorophenyl, 3,5-difluorophenyl, 3,4-dichloro-5-trifluoromethoxyphenyl, 3-iodophenyl, 4-iodophenyl, 3-chloro-1,2-thiazol-5-yl, 7-chloro-1,2-benzothiazol-3-yl, 1,2-Benzoxazol-3-yl, 3,4-Dichloro-1,2-thiazol-5-yl, 4,5-Dichloro-1,2-15thiazol-3-yl, 3-Chloro-4-cyano-1,2-thiazol-5-yl, 1-Methyl-1H-pyrazol-5-yl, 5-Chlorothien-3-yl, 2,5-Dichlorothien-3-yl, 4-Methyl-1,2-oxazol-5-yl, 5-Methyl-1,2-oxazol-3-yl, 4-Methyl-1,3-oxazol-5-yl, 4-Methyl-1,2,3-thiadiazol-5-yl, 4-Methyl-1,3-thiazol-2-yl, 4-Chloro-1,3-Dimethyl-1H-pyrazol-5-yl, 1,3-thiazol-4-yl, 2-chloro-1,3-thiazol-4-yl, 2-chloro-1,3-thiazol-5-yl, 1,3-thiazol-5-yl, 3-difluoromethoxy-5-methylthien-2-yl, 3-difluoromethoxythien-2-yl, 4-bromothien-20 3-yl, 3,4-dibromothien-2-yl, 4-Bromo-3-methoxythien-2-yl, 4-bromo-3-methylthien-2-yl, 5-bromothien-2-yl, 4,5-dichlorothien-2-yl, 5-chlorothien-2-yl, 5-(1-cyanocycloprop-1-yl)thien-2-yl, 4,5-dibromothien-2-yl, 3,5-Dimethyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Trifluoromethyl-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 2,3-dibromophenyl, 2,5-dibromophenyl, 4-bromo-3,5-dichlorophenyl, 2,3-difluorophenyl, 3-fluoro-4-chlorophenyl, 3-methylcarbonyl-5-nitrophenyl, 4,5-dichloro-2-25fluorophenyl, 3,4-Dichloro-2-fluorophenyl, 3,4-Dichloro-5-fluorophenyl, 2,2-Difluoro-1,3-benzodioxol-5-yl, 3-(1-Methylcycloprop-1-yl)-5-trifluoromethoxyphenyl, 3-(Methylaminocarbonyl)-5-trifluoromethoxyphenyl, 2-{2-Chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4- (trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 3-[2-chloro-5-(3,5-dimethyl-2,6-dioxo-4-sulfanylidene-1,3,5-triazinan-1-yl)-4-fluorophenyl]-5-methyl-4,5-dihydro-30 1,2-oxazol-5-yl, 2-[2-chloro-5-(3,5-dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorophenyl]-1,3-thiazol-5-yl, 3-methyl-5-phenyl-4,5-dihydro-1,2-oxazol-5-yl, 3-methyl-4,5-yl dihydro-1,2-oxazol-5-yl is, R2stands for hydrogen, 35 R3stands for Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Cyclopropyl, Cyclobutyl, Vinyl ``` BCS241005-Abroad STR 46 R5, R6stand for hydrogen, R75 R stands for hydrogen, fluorine, chlorine, methyl, methoxy17, R18, R19and R20The n-values stand independently for hydrogen, fluorine, chlorine, bromine, methyl, and methoxy, and Q stands for one of the residues Q-1, Q-2, Q-23, Q-24, Q-26, Q-71, Q-72, Q-89, Q-91, Q-93, Q-115, Q-152, Q-176, Q-179, Q-286, Q-287, Q-301, Q-302, Q-371, Q-441, Q-442, Q-444, Q-471, Q-472, Q-481, Q-489, Q-490, Q-491, Q-499, and Q-500. The above general or preferred residue definitions apply both to the final products of formula (I) and, accordingly, to the starting materials or intermediates required for their preparation. These residue definitions can be combined arbitrarily with one another, including between the specified preferred regions. 15 With regard to the compounds according to the invention, the designations used above and below are explained. These are familiar to those skilled in the art and have, in particular, the meanings explained below: 20 Unless otherwise defined, the designation of chemical groups generally assumes that the connection to the framework or the residue of the molecule is made via the last-mentioned structural element of the chemical group in question, i.e., for example, in the case of (C2-C8)-Alkenyloxy via the oxygen atom, and in the case of heterocyclyl-(C1-C8)-alkyl or R13O(O)C-(C1-C8)-Alkyl each via the carbon atom of the alkyl group. In a compound chemical group such as heterocyclyl-25 (C1-C8)-alkyl or R13O(O)C-(C1-C8)-Alkyl, the term “alkyl” therefore also stands for an alkylene group. Regarding the functional groups C(=O)R13, C(=O)OR13, C(=O)NR11R12, NR11R12, OR13, S(O)mR14The connection to the framework or the rest of the molecule occurs via the first-mentioned structural element of the relevant chemical group. 30 According to the invention, "alkylsulfonyl" – either alone or as part of a chemical group – represents straight-chain or branched alkylsulfonyl, preferably with 1 to 8, or with 1 to 6 carbon atoms, e.g. (but not limited to) (C1-C6)-alkylsulfonyl such as methylsulfonyl, ethylsulfonyl, propylsulfonyl, 1-methylethylsulfonyl, butylsulfonyl, 1-methylpropylsulfonyl, 2-methylpropylsulfonyl, 1,1-dimethylethylsulfonyl, pentylsulfonyl, 1-methylbutylsulfonyl, 2-Methylbutyl-35sulfonyl, 3-Methylbutylsulfonyl, 1,1-Dimethylpropylsulfonyl, 1,2-Dimethylpropylsulfonyl, 2,2-Di-methylpropylsulfonyl, 1-Ethylpropylsulfonyl, Hexylsulfonyl, 1-Methylpentylsulfonyl, 2-Methyl-pentylsulfonyl, 3-Methylpentylsulfonyl, 4-Methylpentylsulfonyl, 1,1-Dimethylbutylsulfonyl, 1,2-Di- BCS241005-Foreign STR 47 methylbutylsulfonyl, 1,3-dimethylbutylsulfonyl, 2,2-dimethylbutylsulfonyl, 2,3-dimethylbutylsulfonyl, 3,3-dimethylbutylsulfonyl, 1-ethylbutylsulfonyl, 2-ethylbutylsulfonyl, 1,1,2-trimethylpropylsulfonyl, 1,2,2-trimethylpropylsulfonyl, 1-ethyl-1-methylpropylsulfonyl and 1-ethyl-2-methylpropylsulfonyl. 5 According to the invention, "heteroarylsulfonyl" means optionally substituted pyridylsulfonyl, pyrimidinylsulfonyl, pyrazinylsulfonyl, or optionally substituted polycyclic heteroarylsulfonyl, in particular optionally substituted quinolinylsulfonyl, for example substituted by fluorine, chlorine, bromine, iodine, cyano, nitro, alkyl, haloalkyl, haloalkoxy, amino, alkylamino, alkylcarbonylamino, dialkylamino, or alkoxy groups. 10 According to the invention, "alkylthio" means—alone or as part of a chemical group—straight-chain or branched S-alkyl, preferably with 1 to 8, or with 1 to 6 carbon atoms, such as (C1-C10)-, (C1-C6)- or (C1-C4)-Alkylthio, e.g. (but not limited to) (C1- C6)-Alkylthio such as methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 15 2-methylpropylthio, 1,1-dimethylethylthio, pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 1,1-dimethylpropylthio, 1,2-Dimethylpropylthio, 2,2-Dimethylpropylthio, 1-Ethylpropylthio, Hexylthio, 1-Methylpentylthio, 2-Methylpentylthio, 3-Methylpentylthio, 4-Methylpentylthio, 1,1-Dimethylbutylthio, 1,2-Dimethylbutylthio, 1,3-Dimethylbutylthio, 2,2-Dimethylbutylthio, 2,3-Dimethylbutylthio, 3,3-Dimethylbutylthio, 1-Ethylbutylthio, 2-Ethylbutylthio, 1,1,2-Tri-20 methylpropylthio, 1,2,2-Trimethylpropylthio, 1-Ethyl-1-methylpropylthio, and 1-Ethyl-2-methylpropylthio. According to the invention, "alkenylthio" means an alkenyl group bonded via a sulfur atom, "alkynylthio" means an alkynyl group bonded via a sulfur atom, "cycloalkylthio" means a cycloalkyl group bonded via a sulfur atom, and "cycloalkenylthio" means a cycloalkenyl group bonded via a sulfur atom. Unless otherwise defined elsewhere, "alkylsulfinyl (alkyl-S(=O)-)" refers to alkyl groups bonded to the framework via -S(=O)-, such as (C1-C10)-, (C1-C6)- or (C1-C4)- 30 Alkylsulfinyl, e.g. (but not limited to) (C1-C6)-Alkylsulfinyl such as methylsulfinyl, ethylsulfinyl, propylsulfinyl, 1-methylethylsulfinyl, butylsulfinyl, 1-methylpropylsulfinyl, 2-methylpropylsulfinyl, 1,1-dimethylethylsulfinyl, pentylsulfinyl, 1-methylbutylsulfinyl, 2-Methylbutylsulfinyl, 3-Methylbutylsulfinyl, 1,1-Dimethylpropylsulfinyl, 1,2-Dimethylpropylsulfinyl, 2,2-Di-methylpropylsulfinyl, 1-Ethylpropylsulfinyl, Hexylsulfinyl, 1-Methylpentylsulfinyl, 2-Methylpentyl-35sulfinyl, 3-Methylpentylsulfinyl, 4-Methylpentylsulfinyl, 1,1-Dimethylbutylsulfinyl, 1,2-Dimethylbutylsulfinyl, 1,3-Dimethylbutylsulfinyl, 2,2-Dimethylbutylsulfinyl, 2,3-Dimethylbutylsulfinyl, 3,3- BCS241005-Abroad STR 48 Dimethylbutylsulfinyl, 1-Ethylbutylsulfinyl, 2-Ethylbutylsulfinyl, 1,1,2-Trimethylpropylsulfinyl, 1,2,2-Trimethylpropylsulfinyl, 1-Ethyl-1-methylpropylsulfinyl and 1-Ethyl-2-methylpropylsulfinyl. Similarly, “alkenylsulfinyl” and “alkynylsulfinyl”, as defined according to the invention, are alkenyl and alkynyl residues, respectively, which are bonded to the framework via -S(=O)-, such as (C2-C10)-, (C2-C6)- or (C2-C4)- Alkenylsulfinyl or (C3-C10)-, (C3-C6)- or (C3-C4)-Alkynylsulfinyl. Analogously, “alkenylsulfonyl” and “alkynylsulfonyl” are defined according to the invention as alkenyl and alkynyl residues respectively, which are linked via -S(=O)2- are bound to the scaffolding, such as (C2-C10)-, (C2-C6)- or (C2-C4)- 10 Alkenylsulfonyl or (C3-C10)-, (C3-C6)- or (C3-C4)-Alkynylsulfonyl. “Alkoxy” means an alkyl group bonded via an oxygen atom, e.g. (but not limited to) (C1-C6)-alkoxy such as methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy, 1,1-dimethylethoxy, pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 1,1-15 dimethylpropoxy, 1,2-dimethylpropoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexoxy, 1-methylpentoxy, 2-methylpentoxy, 3-methylpentoxy, 4-methylpentoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1,1,2-trimethylpropoxy, 1,2,2-Trimethylpropoxy, 1-Ethyl-1-methylpropoxy, and 1-Ethyl-2-methylpropoxy. Alkenyloxy means an alkenyl group bonded via an oxygen atom; alkynyloxy means an alkynyl group bonded via an oxygen atom, such as (C2-C10)-, (C2-C6)- or (C2-C4)-Alkenoxy or (C3-C10)-, (C3-C6)- or (C3-C4)-Alkyneoxy. “Cycloalkyloxy” means a cycloalkyl group bonded via an oxygen atom, and cycloalkenyloxy means a cycloalkenyl group bonded via an oxygen atom. 25 “Alkylcarbonyl” (alkyl-C(=O)-), unless otherwise defined elsewhere, according to the invention stands for alkyl groups that are bonded to the framework via -C(=O)-, such as (C1-C10)-, (C1-C6)- or (C1-C4)- Alkyl carbonyl. The number of C atoms refers to the alkyl group in the alkyl carbonyl group. 30 Analogously, unless otherwise defined elsewhere, “alkenyl carbonyl” and “alkynyl carbonyl” are, according to the invention, alkenyl and alkynyl groups, respectively, which are bonded to the framework via -C(=O)-, such as (C2-C10)-, (C2-C6)- or (C2-C4)-Alkenylcarbonyl or (C2-C10)-, (C2-C6)- or (C2-C4)- Alkynyl carbonyl. The number of carbon atoms refers to the alkenyl or alkynyl residue in the 35-alkenyl or alkynyl carbonyl group, respectively. Alkynyl carbonyl is the 35-carbon group. BCS241005-Abroad STR 49 “Alkoxycarbonyl (Alkyl-O-C(=O)-)”, unless otherwise defined elsewhere: Alkyl groups that are bonded to the skeleton via -O-C(=O)-, such as (C1-C10)-, (C1-C6)- or (C1-C4)-Alkoxycarbonyl. The number of C atoms refers to the alkyl group in the alkoxycarbonyl group. Similarly, unless otherwise defined elsewhere, “alkenyloxycarbonyl” and “alkynyloxycarbonyl” are, according to the invention, 5 for alkenyl and alkynyl groups, respectively, which are bonded to the framework via -O-C(=O)-, such as (C2-C10)-, (C2-C6)- or (C2-C4)-Alkenyloxycarbonyl or (C3-C10)-, (C3-C6)- or (C3-C4)- Alkynyloxycarbonyl. The number of carbon atoms refers to the alkenyl or alkynyl residue in the alkene or alkynyloxycarbonyl group. 10 According to the invention, the term “alkylcarbonyloxy” (alkyl-C(=O)-O-) refers, unless otherwise defined elsewhere, to alkyl residues that are bonded to the skeleton via a carbonyloxy group (-C(=O)-O-) with the oxygen, such as (C1-C10)-, (C1-C6)- or (C1-C4)-Alkylcarbonyloxy. The number of carbon atoms refers to the alkyl group in the alkylcarbonyloxy group. 15 Analogously, “alkenylcarbonyloxy” and “alkynylcarbonyloxy” are defined according to the invention as alkenyl and alkynyl groups, respectively, which are bonded to the framework via (-C(=O)-O-) with the oxygen, such as (C2-C10)-, (C2-C6)- or (C2-C4)-Alkenylcarbonyloxy or (C2-C10)-, (C2-C6)- or (C2-C4)-Alkynylcarbonyloxy. The number of carbon atoms refers to the alkenyl or alkynyl residue in the alkenyl or alkynylcarbonyloxy group. 20 In short forms such as C(O)R13, C(O)OR13, OC(O)NR11R12, or C(O)NR11R12The abbreviation O shown in parentheses represents an oxygen atom bonded to the adjacent carbon atom via a double bond. 25 In abbreviations such as OC(S)OR13, OC(S)SR14, OC(S)NR11R12The abbreviation S in parentheses represents a sulfur atom bonded to the adjacent carbon atom via a double bond. The term "aryl" means an optionally substituted mono-, bi-, or polycyclic aromatic system with preferably 6 to 14, in particular 6 to 10 ring carbon atoms, for example phenyl, naphthyl, anthryl, phenanthrenyl, and the like, preferably phenyl or naphthyl, and in particular preferably phenyl. The term "optionally substituted aryl" also includes multicyclic systems such as tetrahydronaphtyl, indenyl, indanyl, fluorenyl, and biphenylyl, where the bonding site is on the aromatic system. From a systematic perspective, "aryl" is generally also encompassed by the term "optionally substituted phenyl." Preferred aryl substituents are, for example, BCS241005-Ausland STR 50 hydrogen, halogen, alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, halocycloalkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkoxyalkyl, alkylthio, haloalkylthio, haloalkyl, Alkoxy, haloalkoxy, cycloalkoxy, cycloalkylalkoxy, aryloxy, heteroraryloxy, alkoxyalkoxy, alkynylalkoxy, alkenyloxy, bis-alkylaminoalkoxy, tris-5[alkyl]silyl, bis-[alkyl]arylsilyl, bis-[alkyl]alkylsilyl, tris-[alkyl]silylalkynyl, arylalkynyl, Heteroarylalkynyl, alkylalkynyl, cycloalkylalkynyl, haloalkylalkynyl, heterocyclyl-N-alkoxy, Nitro, Cyano, Amino, Alkylamino, Bis-alkylamino, Alkylcarbonylamino, Cycloalkylcarbonylamino, Arylcarbonylamino, Alkoxycarbonylamino, Alkoxycarbonylalkylamino, Arylalkoxycarbonylalkylamino, Hydroxycarbonyl, Alkoxycarbonyl, Aminocarbonyl, Alkylaminocarbonyl, Cycloalkylaminocarbonyl, Bis-Alkylaminocarbonyl, Heteroarylalkoxy, Arylalkoxy. Unless otherwise defined herein in a specific context, a “heterocyclic residue” (“heterocyclyl”) contains at least one heterocyclic ring (=carbocyclic ring in which at least one carbon atom is replaced by a heteroatom, preferably by a heteroatom from the group N, O, S, P) which is saturated, unsaturated, partially saturated or heteroaromatic and may be unsubstituted or substituted, wherein the bonding site is localized on a ring atom. If the heterocyclyl residue or the heterocyclic ring is optionally substituted, it may be fused to other carbocyclic or heterocyclic rings. In the case of optionally substituted heterocyclyl, multicyclic systems are also included, such as 8-aza-bicyclo[3.2.1]octanyl, 8-aza-bicyclo[2.2.2]octanyl, or 1-aza-bicyclo[2.2.1]heptyl. In the case of optionally substituted heterocyclyl, spirocyclic systems are also included, such as 1-oxa-5-aza-spiro[2.3]hexyl. Unless otherwise defined, the heterocyclic ring preferably contains 3 to 9 ring atoms, in particular 3 to 6 ring atoms, and one or more, 25 preferably 1 to 4, in particular 1, 2 or 3 heteroatoms in the heterocyclic ring, preferably from the group N, O, and S, wherein, however, no two oxygen atoms should be directly adjacent, such as with a heteroatom from the group N, O and S 1- or 2- or 3-pyrrolidinyl, 3,4-dihydro-2H-pyrrole-2- or 3-yl, 2,3-dihydro-1H-pyrrole-1- or 2- or 3- or 4- or 5-yl; 2,5-dihydro-1H-pyrrole-1- or 2- or 3- or 3-yl, 1- or 2- or 3- or 4-piperidinyl; 2,3,4,5-30 Tetrahydropyridin-2-, 3-, 4-, or 5-yl or 6-yl; 1,2,3,6-Tetrahydropyridin-1-, 2-, 3-, 4-, 5-, or 6-yl; 1,2,3,4-Tetrahydropyridin-1-, 2-, 3-, 4-, 5-, or 6-yl; 1,4-Dihydropyridin-1-, 2-, 3-, or 4-yl; 2,3-Dihydropyridin-2-, 3-, 4-, 5-, or 6-yl; 2,5-Dihydropyridin-2-, 3-, 4-, 5-, or 6-yl, 1-, 2-, 3-, or 4-Azepanyl; 2,3,4,5-Tetrahydro-1H-azepin-1- or 2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-Tetrahydro-1H-35 azepin-1- or 2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-Tetrahydro-1H-azepin-1- or 2- or 3- or 4-yl; 3,4,5,6-Tetrahydro-2H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5-Dihydro-1H-azepin-1- or 2- or 3- or 4-yl; 2,5-Dihydro-1H-azepin-1- or -2- or 3- or 4- or BCS241005-Abroad STR 51 5- or 6- or 7-yl; 2,7-Dihydro-1H-azepin-1- or -2- or 3- or 4-yl; 2,3-Dihydro-1H-azepin-1- or -2- or 3- or 4- or 5- or 6- or 7-yl; 3,4-Dihydro-2H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 3,6-Dihydro-2H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 5,6-Dihydro-2H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5-Dihydro-3H-azepine-2-, 3-, 4-, 5-, 6-, or 7-yl; 1H-azepine-1-, 2-, 3-, 4-, 5-, 6-, or 7-yl; 2H-azepine-2-, 3-, 4-, 5-, 6-, or 7-yl; 3H-azepine-2-, 3-, 4-, 5-, 6-, or 7-yl; 4H-azepine-2-, 3-, 4-, 5-, 6-, or 7-yl; 2- or 3-oxolanyl (= 2- or 3-tetrahydrofuranyl); 2,3-Dihydrofuran-2-, 3-, 4-, or 5-yl; 2,5-Dihydrofuran-2- or 3-yl, 2- or 3- or 4-oxanyl (= 2- or 3- or 4-tetrahydropyranyl); 3,4-Dihydro-2H-pyran-2- or 3- or 4- or 5- or 6-yl; 3,6-10-Dihydro-2H-pyran-2- or 3- or 4- or 5- or 6-yl; 2H-pyran-2- or 3- or 4- or 5- or 6-yl; 4H-pyran-2- or 3- or 4-yl, 2- or 3- or 4-oxepanyl; 2,3,4,5-Tetrahydrooxepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-Tetrahydrooxepin-2-, 3-, 4-, 5-, 6-, or 7-yl; 2,3,6,7-Tetrahydrooxepin-2-, 3-, or 4-yl; 2,3-Dihydrooxepin-2-, 3-, 4-, 5-, 6-, or 7-yl; 4,5-Dihydrooxepin-2-, 3-, or 4-yl; 2,5-Dihydrooxepin-2-, 3-, 4-, 5-, 6-, or 7-yl; 15-Oxepin-2-, 3-, 4-, 5-, 6-, or 7-yl; 2- or 3-Tetrahydrothiophenyl; 2,3-Dihydrothiophen-2-, 3-, 4-, or 5-yl; 2,5-Dihydrothiophen-2- or 3-yl; Tetrahydro-2H-thiopyran-2- or 3- or 4-yl; 3,4-Dihydro-2H-thiopyran-2- or 3- or 4- or 5- or 6-yl; 3,6-Dihydro-2H-thiopyran-2- or 3- or 4- or 5- or 6-yl; 2H-Thiopyran-2- or 3- or 4- or 5- or 6-yl; 4H-Thiopyran-2- or 3- or 4-yl. Preferred 3-ring and 4-ring heterocycles are, for example, 1- or 2-aziridinyl, oxiranyl, thiiranyl, 1- or 2- or 3-acetidinyl, 2- or 3-oxetanyl, 2- or 3-thietanyl, and 1,3-dioxetan-2-yl. Further examples of “heterocyclyl” are a partially or fully hydrogenated heterocyclic residue with two heteroatoms from the group N, O, and S, such as 1- or 2- or 3- or 4-pyrazolidinyl; 4,5-dihydro-3H-pyrazole-3- or 4- or 5-yl; and 4,5-dihydro-1H-pyrazole-1- or 3- or 4- or 5-yl. 2,3-Dihydro-1H-pyrazole-1-, 2-, 3-, 25-, 4-, or 5-yl; 1-, 2-, 3-, or 4-imidazolidinyl; 2,3-Dihydro-1H-imidazol-1-, 2-, 3-, or 4-yl; 2,5-Dihydro-1H-imidazol-1-, 2-, 4-, or 5-yl; 4,5-Dihydro-1H-imidazol-1-, 2-, 4-, or 5-yl; Hexahydropyridazine-1-, 2-, 3-, or 4-yl; 1,2,3,4-Tetrahydropyridazine-1-, 2-, 3-, 4-, 5-, or 6-yl; 1,2,3,6-Tetrahydropyridazine-1-, 2-, 3-, 4-, 5-, or 6-yl; 1,4,5,6-Tetrahydropyridazine-1-, 3-, 4-, 5-, or 6-yl; 3,4,5,6-Tetrahydropyridazine-3-, 30-, 4-, or 5-yl; 4,5-Dihydropyridazine-3- or 4-yl; 3,4-Dihydropyridazine-3-, 4-, 5-, or 6-yl; 3,6-Dihydropyridazine-3- or 4-yl; 1,6-Dihydropyriazine-1-, 3-, 4-, 5-, or 6-yl; Hexahydropyrimidine-1-, 2-, 3-, or 4-yl; 1,4,5,6-Tetrahydropyrimidin-1-, 2-, 4-, 5-, or 6-yl; 1,2,5,6-Tetrahydropyrimidin-1-, 2-, 4-, 5-, or 6-yl; 1,2,3,4-Tetrahydropyrimidin-1-, 2-, 3-, 4-, 5-, or 6-yl; 1,6-Dihydropyrimidin-1-, 2-, 4-, 5-, or 6-yl; 1,2-Dihydropyrimidin-1-, 2-, 4-, 5-, or 6-yl; 2,5-Dihydropyrimidin-2-, 4-, or 5-yl; 4,5-Dihydropyrimidin-4-, 5-, or 6-yl; 1,4-Dihydropyrimidine-1-, 2-, 4-, 5-, or 6-yl; 1-, 2-, or 3-piperazinyl; 1,2,3,6-Tetrahydropyrazine-1-, 2-, 3-, or 5- BCS241005-Foreign STR 52 or 6-yl; 1,2,3,4-Tetrahydropyrazine-1- or 2- or 3- or 4- or 5- or 6-yl; 1,2-Dihydropyrazine-1- or 2- or 3- or 5- or 6-yl; 1,4-Dihydropyrazine-1- or 2- or 3-yl; 2,3-Dihydropyrazine-2- or 3- or 5- or 6-yl; 2,5-Dihydropyrazine-2- or 3-yl; 1,3-Dioxolane-2- or 4- or 5-yl; 1,3-Dioxol-2- or 4-yl; 1,3-Dioxane-2- or 4- or 5-yl; 4H-1,3-dioxin-2-, 4-, 5-, or 6-yl; 1,4-dioxane-2-, 5-, 3-, 5-, or 6-yl; 2,3-dihydro-1,4-dioxin-2-, 3-, 5-, or 6-yl; 1,4-dioxin-2- or 3-yl; 1,2-dithiolane-3- or 4-yl; 3H-1,2-dithiol-3-, 4-, or 5-yl; 1,3-dithiolane-2- or 4-yl; 1,3-dithiol-2- or 4-yl; 1,2-dithiane-3- or 4-yl; 3,4-dihydro-1,2-dithiin-3-, 4-, 5-, or 6-yl; 3,6-Dihydro-1,2-dithiin-3- or 4-yl; 1,2-Dithiin-3- or 4-yl; 1,3-Dithiin-2- or 4- or 5-yl; 4H-1,3-Dithiin-2- or 4- or 5- or 6-yl; Isoxazolidin-2- or 3- or 4- or 5-yl; 2,3-Dihydroisoxazol-2- or 3- or 104- or 5-yl; 2,5-Dihydroisoxazol-2- or 3- or 4- or 5-yl; 4,5-Dihydroisoxazol-3- or 4- or 5-yl; 1,3-Oxazolidin-2- or 3- or 4- or 5-yl; 2,3-Dihydro-1,3-oxazol-2-, 3-, 4-, or 5-yl; 2,5-Dihydro-1,3-oxazol-2-, 4-, or 5-yl; 4,5-Dihydro-1,3-oxazol-2-, 4-, or 5-yl; 1,2-Oxazinan-2-, 3-, 4-, 5-, or 6-yl; 3,4-Dihydro-2H-1,2-oxazine-2-, 3-, 4-, 5-, or 6-yl; 3,6-Dihydro-2H-1,2-oxazine-2-, 3-, 4-, 5-, or 6-yl; 5,6-Dihydro-2H-1,2-oxazine-2-, 3-, 4-, 5-, or 6-yl; 5,6-Dihydro-4H-1,2-oxazine-3-, 4-, 5-, or 6-yl; 2H-1,2-oxazine-2-, 3-, 4-, 5-, or 6-yl; 6H-1,2-oxazine-3-, 4-, 5-, or 6-yl; 4H-1,2-oxazine-3-, 4-, 5-, or 6-yl; 1,3-oxazinan-2-, 3-, 4-, 5-, or 6-yl; 3,4-Dihydro-2H-1,3-oxazine-2-, 3-, 4-, 5-, or 6-yl; 3,6-Dihydro-2H-1,3-oxazine-2-, 3-, 4-, 5-, or 6-yl; 5,6-Dihydro-2H-1,3-oxazine-2-, 4-, 5-, or 6-yl; 5,6-Dihydro-4H-1,3-oxazine-2-, 4-, 5-, or 6-yl; 2H-201,3-oxazine-2-, 4-, 5-, or 6-yl; 6H-1,3-oxazine-2-, 4-, 5-, or 6-yl; 4H-1,3-oxazine-2-, 4-, 5-, or 6-yl; Morpholine-2-, 3-, or 4-yl; 3,4-Dihydro-2H-1,4-oxazine-2-, 3-, 4-, 5-, or 6-yl; 3,6-Dihydro-2H-1,4-oxazine-2- or 3- or 5- or 6-yl; 2H-1,4-oxazine-2- or 3- or 5- or 6-yl; 4H-1,4-oxazine-2- or 3-yl; 1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,5-Tetrahydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-Tetrahydro-1,2-25-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-Tetrahydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5,6,7-Tetrahydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5,6,7-Tetrahydro-1,2-oxazepine-3- or 4- or 5- or 6- or 7-yl; 2,3-Dihydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5-Dihydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,7-Dihydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5-Dihydro-1,2-oxazepine-3- or 4- or 5- or 6- or 7-yl; 4,7-Dihydro-1,2-oxazepine-3- or 4- or 5- or 6- or 7-yl; 6,7-Dihydro-1,2-oxazepine-3- or 4- or 5- or 6- or 7-yl; 1,2-Oxazepine-3- or 4- or 5- or 6- or 7-yl; 1,3-Oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,5-Tetrahydro-1,3-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-Tetrahydro-1,3-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-Tetrahydro-1,3-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5,6,7-Tetrahydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 4,5,6,7-Tetrahydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 2,3-Dihydro-1,3-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5-Dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 2,7-Dihydro-1,3-oxazepine- ...] BCS241005-Abroad STR 53 2- or 4- or 5- or 6- or 7-yl; 4,5-Dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 4,7-Dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 6,7-Dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 1,3-Oxazepine-2- or 4- or 5- or 6- or 7-yl; 1,4-Oxazepine-2- or 3- or 5- or 6- or 7-yl; 2,3,4,5-Tetrahydro-1,4-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-5 Tetrahydro-1,4-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-Tetrahydro-1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; 2,5,6,7-Tetrahydro-1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; 4,5,6,7-Tetrahydro-1,4-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3-Dihydro-1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; 2,5-Dihydro-1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; 2,7-Dihydro-1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; 4,5-Dihydro-1,4-oxazepine-2- or 10,3- or 4- or 5- or 6- or 7-yl; 4,7-Dihydro-1,4-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 6,7-Dihydro-1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; 1,4-Oxazepine-2-, 3-, 5-, 6-, or 7-yl; Isothiazolidin-2-, 3-, 4-, or 5-yl; 2,3-Dihydroisothiazol-2-, 3-, 4-, or 5-yl; 2,5-Dihydroisothiazol-2-, 3-, 4-, or 5-yl; 4,5-Dihydroisothiazol-3-, 4-, or 5-yl; 1,3-Thiazolidin-2-, 3-, 4-, or 5-yl; 2,3-Dihydro-1,3-thiazol-2-, 3-, 4-, or 5-yl; 2,5-Dihydro-1,3-thiazol-2-, 4-, or 5-yl; 4,5-Dihydro-1,3-thiazol-2-, 4-, or 5-yl; 1,3-Thiazinan-2-, 3-, 4-, 5-, or 6-yl; 3,4-Dihydro-2H-1,3-thiazine-2-, 3-, 4-, 5-, or 6-yl; 3,6-Dihydro-2H-1,3-thiazine-2-, 3-, 4-, 5-, or 6-yl; 5,6-Dihydro-2H-1,3-thiazine-2-, 4-, 5-, or 6-yl; 5,6-Dihydro-4H-1,3-thiazine-2-, 4-, 5-, or 6-yl; 2H-1,3-thiazine-2-, 4-, 5-, or 6-yl; 6H-1,3-thiazine-2-, 4-, 5-, or 6-yl; 4H-1,3-thiazine-2-, 4-, 5-, or 6-yl. 20 Other examples of “heterocyclyl” are a partially or fully hydrogenated heterocyclic residue with 3 heteroatoms from the group N, O, and S, such as 1,4,2-dioxazolidin-2-, 3-, or 5-yl; 1,4,2-dioxazol-3- or 5-yl; 1,4,2-dioxazinan-2-, 3-, 5-, or 6-yl; 5,6-dihydro-1,4,2-dioxazin-3-, 5-, or 6-yl; 1,4,2-dioxazin-3-, 5-, or 6-yl; 1,4,2-dioxazepane-2-, 3-, 5-, 6-, or 7-yl; 6,7-Dihydro-5H-1,4,2-dioxazepine-3-, 5-, 6-, or 7-yl; 2,3-Dihydro-7H-1,4,2-25-dioxazepine-2-, 3-, 5-, 6-, or 7-yl; 2,3-Dihydro-5H-1,4,2-dioxazepine-2-, 3-, 5-, 6-, or 7-yl; 5H-1,4,2-dioxazepine-3-, 5-, 6-, or 7-yl; 7H-1,4,2-dioxazepine-3-, 5-, 6-, or 7-yl. Examples of structures for potentially further substituted heterocycles are also listed below: BCS241005-Abroad STR 54 BCS241005-Abroad STR 55 ``` The heterocycles listed above are preferably, for example, hydrogen, halogen, alkyl, haloalkyl, hydroxy, alkoxy, cycloalkoxy, aryloxy, alkoxyalkyl, alkoxyalkoxy, cycloalkyl, halocycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclyl, alkenyl, alkylcarbonyl, cycloalkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, Alkoxycarbonyl, hydroxycarbonyl, cycloalkoxycarbonyl, cycloalkylalkoxycarbonyl, alkoxycarbonylalkyl, arylalkoxycarbonyl, arylalkoxycarbonylalkyl, alkynyl, alkynylalkyl, alkylalkynyl, tris-alkylsilylalkynyl, nitro, amino, cyano, haloalkoxy, BCS241005-Abroad STR 56 Haloalkylthio, Alkylthio, Hydrothio, Hydroxyalkyl, Oxo, Heteroarylalkoxy, Arylalkoxy, Heterocyclylalkoxy, Heterocyclylalkylthio, Heterocyclyloxy, Heterocyclylthio, Heteroaryloxy, Bis-alkylamino, Alkylamino, Cycloalkylamino, Hydroxycarbonylalkylamino, Alkoxycarbonylalkylamino, arylalkoxycarbonylalkylamino, alkoxycarbonylalkyl(alkyl)amino, aminocarbonyl, 5alkylaminocarbonyl, bis-alkylaminocarbonyl, cycloalkylaminocarbonyl, hydroxycarbonylalkylaminocarbonyl, alkoxycarbonylalkylaminocarbonyl, arylalkoxycarbonylalkylaminocarbonyl substituted. If a parent compound is substituted "by one or more residues" from an enumeration of residues (= group) 10 or a generically defined group of residues, this always includes the simultaneous substitution by several identical and/or structurally different residues. If it is a partially or fully saturated nitrogen heterocycle, it can be linked to the rest of the molecule via either carbon or nitrogen. 15 The substituents listed below are suitable for a substituted heterocyclic residue, as are oxo and thioxo. The "oxo group" as a substituent on a ring carbon atom then means, for example, a carbonyl group in the heterocyclic ring. This preferably also includes lactones and lactams. The oxo group can also occur on the 20 heteroring atoms, which can exist in different oxidation states, e.g., on N and S, and then form, for example, the divalent groups N(O) , S(O) (also abbreviated SO) and S(O) .2(also abbreviated SO)2) in the heterocyclic ring. In the case of –N(O)- and –S(O)- groups, both enantiomers are included. 25 According to the invention, the term “heteroaryl” stands for heteroaromatic compounds, i.e., completely unsaturated aromatic heterocyclic compounds, preferably for 5- to 7-membered rings with 1 to 4, preferably 1 or 2 identical or different heteroatoms, preferably O, S, or N. Heteroaryls according to the invention are, for example, 1H-pyrrol-1-yl; 1H-pyrrol-2-yl; 1H-pyrrol-3-yl; furan-2-yl; furan-3-yl; thien-2-yl; thien-3-yl; 1H-imidazol-1-yl; 1H-imidazol-2-yl; 1H-imidazol-304-yl; 1H-imidazol-5-yl; 1H-pyrazol-1-yl; 1H-pyrazol-3-yl; 1H-pyrazol-4-yl; 1H-pyrazol-5-yl, 1H-1,2,3-triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-3-yl, 4H-1,2,4-triazol-4-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl, 1,3,4-oxadiazol-2-yl, 1,2,3-oxadiazol-4-yl, 1,2,3-oxadiazol-5-yl, 1,2,5-oxadiazol-3-yl, Azepinyl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, 35 pyrimidin-4-yl, pyrimidin-5-yl, pyridazin-3-yl, pyridazin-4-yl, 1,3,5-triazin-2-yl, 1,2,4-triazin-3-yl, 1,2,4-triazin-5-yl, 1,2,4-triazin-6-yl, 1,2,3-triazin-4-yl, 1,2,3-triazin-5-yl, 1,2,4-, 1,3,2-, 1,3,6- and 1,2,6-oxazinyl, Isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3- BCS241005-Foreign STR 57 Oxazol-5-yl, Isothiazol-3-yl, Isothiazol-4-yl, Isothiazol-5-yl, 1,3-thiazol-2-yl, 1,3-thiazol-4-yl, 1,3-thiazol-5-yl, oxepinyl, thiepinyl, 1,2,4-triazolonyl and 1,2,4-diazepinyl, 2H-1,2,3,4-tetrazol-5-yl, 1H-1,2,3,4-tetrazol-5-yl, 1,2,3,4-oxatriazol-5-yl, 1,2,3,4-thiatriazol-5-yl, 1,2,3,5-oxatriazol-4-yl, 1,2,3,5-Thiatriazol-4-yl. The heteroaryl groups according to the invention can further be substituted with one or more identical or different substituents. If two adjacent carbon atoms are part of another aromatic ring, the resulting systems are fused heteroaromatics, such as benzo-condensed or multiply fused heteroaromatics. For example, quinolines (e.g., quinoline-2-yl, quinoline-3-yl, quinoline-4-yl, quinoline-5-yl, quinoline-6-yl, quinoline-7-yl, quinoline-8-yl); isoquinolines (e.g., isoquinoline-1-yl, isoquinoline-3-yl, isoquinoline-4-yl, isoquinoline-5-yl, isoquinoline-6-yl, isoquinoline-7-yl, isoquinoline-8-yl); quinoxaline; quinazoline; cinnoline; 1,5-naphthyridine; 1,6-naphthyridine; 1,7-naphthyridine; 1,8-naphthyridine; 2,6-naphthyridine; 2,7-naphthyridine; phthalazine; pyridopyrazines; pyridopyrimidines; pyridopyridazines; pteridines; Pyrimidopyrimidines. Examples of heteroaryls also include 5- or 6-membered benzo-condensed rings from the group 1H-indol-1-yl, 1H-indol-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol-5-yl, 1H-15-indol-6-yl, 1H-indol-7-yl, 1-benzofuran-2-yl, 1-benzofuran-3-yl, 1-benzofuran-4-yl, 1-benzofuran-5-yl, 1-benzofuran-6-yl, 1-benzofuran-7-yl, 1-benzothiophen-2-yl, 1-benzothiophen-3-yl, 1-benzothiophen-4-yl, 1-benzothiophen-5-yl, 1-benzothiophen-6-yl, 1-Benzothiophen-7-yl, 1H-Indazol-1-yl, 1H-Indazol-3-yl, 1H-Indazol-4-yl, 1H-Indazol-5-yl, 1H-Indazol-6-yl, 1H-Indazol-7-yl, 2H-Indazol-2-yl, 2H-Indazol-3-yl, 2H-Indazol-4-yl, 2H-Indazol-5-yl, 2H-Indazol-6-yl, 2H-Indazol-7-yl, 2H-20Isoindol-2-yl, 2H-Isoindol-1-yl, 2H-Isoindol-3-yl, 2H-Isoindol-4-yl, 2H-Isoindol-5-yl, 2H-Isoindol-6-yl; 2H-Isoindol-7-yl, 1H-Benzimidazol-1-yl, 1H-Benzimidazol-2-yl, 1H-Benzimidazol-4-yl, 1H-Benzimidazol-5-yl, 1H-Benzimidazol-6-yl, 1H-Benzimidazol-7-yl, 1,3-Benzoxazol-2-yl, 1,3- Benzoxazol-4-yl, 1,3-Benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-Benzoxazol-7-yl, 1,3-Benzthiazol-2-yl, 1,3-Benzthiazol-4-yl, 1,3-Benzthiazol-5-yl, 1,3-Benzthiazol-6-yl, 1,3-Benzthiazol-7-yl, 1,2-25 benzisoxazol-3-yl, 1,2-Benzisoxazol-4-yl, 1,2-Benzisoxazol-5-yl, 1,2-Benzisoxazol-6-yl, 1,2-Benzisoxazol-7-yl, 1,2-Benzisothiazol-3-yl, 1,2-Benzisothiazol-4-yl, 1,2-Benzisothiazol-5-yl, 1,2-Benzisothiazol-6-yl, 1,2-Benzisothiazol-7-yl. The term "halogen" means, for example, fluorine, chlorine, bromine, or iodine. If the designation is used for a residue, then "halogen" means, for example, a fluorine, chlorine, bromine, or iodine atom. According to the invention, "alkyl" means a straight-chain or branched open-chain saturated hydrocarbon residue, which is optionally one- or multiple-substituted and, in the latter case, is referred to as "substituted alkyl". Preferred substituents are halogen atoms, alkoxy, haloalkoxy, cyano, alkylthio, haloalkylthio, amino, or nitro groups; methoxy, methyl, fluoroalkyl, cyano, nitro, fluorine, chlorine, bromine, or iodine are particularly preferred. The prefix "bis" indicates... BCS241005-Abroad STR 58 also includes the combination of different alkyl groups, e.g., methyl(ethyl) or ethyl(methyl). Alkyl groups can have different names for the same group depending on the notation used, but these are generally accepted in the field. For example, the names 1-methyleth-1-yl, 1-methylethyl, prop-2-yl, and iso-propyl are synonymous. 5. "Haloalkyl," "-alkenyl," and "-alkynyl" mean alkyl partially or completely substituted by the same or different halogen atoms, alkenyl or alkynyl, e.g., monohaloalkyl (= monohaloalkyl) such as CH₄.2CH2Cl, CH2CH2Br, CHClCH3, CH2Cl, CH2F; Perhaloalkyl such as CCl3,CClF2,CFCl2,CF2CClF2,CF2CClFCF3; Polyhaloalkyl such as CH2CHFCl, CF2CClFH, 10 CF2CBrFH, CH2CF3The term perhaloalkyl also includes the term perfluoroalkyl. "Haloalkoxy" is, for example, OCF.3OCHF2, OCH2F, OCF2CF3, OCH2CF3and OCH2CH2Cl; The same applies to haloalkenyl and other halogen-substituted residues. 15 The expression "(C1-C4)-Alkyl" is a shorthand notation for straight-chain or branched alkyl with one to four carbon atoms, depending on the specified range for carbon atoms, i.e., it includes the groups methyl, ethyl, 1-propyl, 2-propyl, 1-butyl, 2-butyl, 2-methylpropyl, or tert-butyl. General alkyl groups with a larger specified range of carbon atoms, e.g., "(C1-C6The term "alkyl" also includes straight-chain or branched alkyl groups with a larger number of carbon atoms, i.e., as in the example, also alkyl groups with 5 and 6 carbon atoms. Unless otherwise specified, for hydrocarbon groups such as alkyl, alkenyl, and alkynyl groups, including those in compound groups, the lower carbon skeletons are preferred, e.g., with 1 to 6 carbon atoms or, in the case of unsaturated groups, with 2 to 6 carbon atoms. Alkyl groups, including those in compound groups such as alkoxy, haloalkyl, etc., include, for example, methyl, ethyl, n- or i-propyl, n-, i-, t-, or 2-butyl, pentyls, hexyls such as n-hexyl, i-hexyl, and 1,3-dimethylbutyl, and heptyls such as... n-Heptyl, 1-methylhexyl, and 1,4-dimethylpentyl; alkenyl and alkynyl groups have the meaning of the possible unsaturated groups corresponding to the alkyl groups, containing at least one double bond 30 or triple bond, respectively. Groups with one double bond or triple bond are preferred. The term "alkenyl" also includes, in particular, straight-chain or branched open-chain hydrocarbon groups with more than one double bond, such as 1,3-butadienyl and 1,4-pentadienyl, 35 but also allenyl or cumulenyl groups with one or more cumulated double bonds, such as allenyl (1,2-propadienyl), 1,2-butadienyl, and 1,2,3-pentatrienyl. Alkenyl means, for example, vinyl, which may optionally be substituted by further alkyl groups, e.g. (but not limited to) BCS241005-Abroad STR 59 (C)2-C6)-Alkenyl such as ethenyl, 1-propenyl, 2-propenyl, 1-methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-Pentenyl, 3-Pentenyl, 4-Pentenyl, 1-Methyl-1-butenyl, 2-Methyl-1-butenyl, 3-Methyl-1-butenyl, 1-Methyl-2-butenyl, 2-Methyl-2-butenyl, 3-Methyl-2-butenyl, 1-Methyl-3-butenyl, 2-Methyl-3-5 butenyl, 3-Methyl-3-butenyl, 1,1-Dimethyl-2-propenyl, 1,2-Dimethyl-1-propenyl, 1,2-Dimethyl-2-propenyl, 1-Ethyl-1-propenyl, 1-Ethyl-2-propenyl, 1-Hexenyl, 2-Hexenyl, 3-Hexenyl, 4-Hexenyl, 5- hexenyl, 1-methyl-1-pentenyl, 2-methyl-1-pentenyl, 3-methyl-1-pentenyl, 4-methyl-1-pentenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2-pentenyl, 1-methyl-3-pentenyl, 2-methyl-3-pentenyl, 3-methyl-3-pentenyl, 4-Methyl-3-pentenyl, 1-Methyl-4-pentenyl, 2-10 Methyl-4-pentenyl, 3-Methyl-4-pentenyl, 4-Methyl-4-pentenyl, 1,1-Dimethyl-2-butenyl, 1,1-Dimethyl-3-butenyl, 1,2-Dimethyl-1-butenyl, 1,2-Dimethyl-2-butenyl, 1,2-Dimethyl-3-butenyl, 1,3-Dimethyl-1-butenyl, 1,3-Dimethyl-2-butenyl, 1,3-Dimethyl-3-butenyl, 2,2-Dimethyl-3-butenyl, 2,3-Dimethyl-1-butenyl, 2,3-Dimethyl-2-butenyl, 2,3-Dimethyl-3-butenyl, 3,3-Dimethyl-1-butenyl, 3,3-Dimethyl-2-butenyl, 1-Ethyl-1-butenyl, 1-Ethyl-2-butenyl, 1-Ethyl-3-butenyl, 2-Ethyl-1-butenyl, 2-Ethyl-2-butenyl, 15-2-Ethyl-3-butenyl, 1,1,2-Trimethyl-2-propenyl, 1-Ethyl-1-methyl-2-propenyl, 1-Ethyl-2-methyl-1-propenyl, and 1-Ethyl-2-methyl-2-propenyl. The term "alkynyl" also includes, in particular, straight-chain or branched open-chain hydrocarbon residues with more than one triple bond or with one or more triple bonds and one or more double bonds, such as 1,3-butatrienyl or 3-penten-1-yne-1-yl. (C2-C6)-Alkynyl means, for example, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-Methyl-3-25pentynyl, 1-Methyl-4-pentynyl, 2-Methyl-3-pentynyl, 2-Methyl-4-pentynyl, 3-Methyl-1-pentynyl, 3-Methyl-4-pentynyl, 4-Methyl-1-pentynyl, 4-Methyl-2-pentynyl, 1,1-Di-methyl-2-butynyl, 1,1-Dimethyl-3-butynyl, 1,2-Dimethyl-3-butynyl, 2,2-Dimethyl-3-butynyl, 3,3-Dimethyl-1-butynyl, 1-Ethyl-2-butynyl, 1-Ethyl-3-butynyl, 2-Ethyl-3-butynyl and 1-Ethyl-1-methyl-2-propynyl. 30 The term “cycloalkyl” means a carbocyclic saturated ring system with preferably 3-8 ring carbon atoms, e.g., cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, which is optionally further substituted, preferably by hydrogen, alkyl, alkoxy, oxo, cyano, nitro, alkylthio, haloalkylthio, halogen, alkenyl, alkynyl, haloalkyl, amino, alkylamino, bisalkylamino, alkoxycarbonyl, hydroxycarbonyl, arylalkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, 35 cycloalkylaminocarbonyl. In the case of optionally substituted cycloalkyl, cyclic systems with substituents are included, wherein substituents with a double bond on the cycloalkyl group, e.g., an alkylidene group such as methylidene, are also included. In the case of optionally BCS241005-Ausland STR 60 substituted cycloalkyl also includes multicyclic aliphatic systems, such as bicyclo[1.1.0]butan-1-yl, bicyclo[1.1.0]butan-2-yl, bicyclo[2.1.0]pentan-1-yl, bicyclo[1.1.1]pentan-1-yl, bicyclo[2.1.0]pentan-2-yl, bicyclo[2.1.0]pentan-5-yl, bicyclo[2.1.1]hexyl, bicyclo[2.2.1]hept-2-yl, bicyclo[2.2.2]octan-2-yl, bicyclo[3.2.1]octan-2-yl, bicyclo[3.2.2]nonan-2-yl, adamantan-1-yl and 5 adamantan-2-yl, but also systems such as... B.1,1'-Bi(cyclopropyl)-1-yl, 1,1'-Bi(cyclopropyl)-2-yl. The expression "(C3-C7)-Cycloalkyl" is a shorthand notation for cycloalkyl with three to seven carbon atoms, corresponding to the range specified for the number of carbon atoms. In the case of substituted cycloalkyl, spirocyclic aliphatic systems are also included, such as, for example, Spiro[2.2]pent-1-yl, Spiro[2.3]hex-1-yl, Spiro[2.3]hex-4-yl, 3-Spiro[2.3]hex-5-yl, Spiro[3.3]hept-1-yl, Spiro[3.3]hept-2-yl. "Cycloalkenyl" means a carbocyclic, non-aromatic, partially unsaturated ring system with preferably four to eight carbon atoms, e.g., 1-cyclobutenyl, 2-cyclobutenyl, 1-cyclopentenyl, 2-cyclopentenyl, 15 3-Cyclopentenyl, or 1-cyclohexenyl, 2-cyclohexenyl, 3-cyclohexenyl, 1,3-cyclohexadienyl, or 1,4-cyclohexadienyl, including substituents with a double bond on the cycloalkenyl residue, e.g., an alkylidene group such as methylidene. In the case of optionally substituted cycloalkenyl, the explanations for substituted cycloalkyl apply accordingly. 20 The term “alkylidene”, e.g., also in the form (C1-C10)-Alkylidene refers to the residue of a straight-chain or branched open-chain hydrocarbon group that is bonded via a double bond. Naturally, only positions on the parent compound where two hydrogen atoms can be replaced by the double bond are suitable for alkylidene bonding sites; examples of residues are =CH₂.2, =CH-CH3, =C(CH3)-CH3, =C(CH3)-C2H5or =C(C2H5)-C2H5.Cycloalkylidene means a 25 carbocyclic group bonded via a double bond. "Cycloalkylalkyloxy" means a cycloalkylalkyl group bonded via an oxygen atom, and "arylalkyloxy" means an arylalkyl group bonded via an oxygen atom. "Alkoxyalkyl" stands for an alkoxy group bonded via an alkyl group, and "alkoxyalkoxy" means an alkoxyalkyl group bonded via an oxygen atom, e.g., (but not limited to) methoxymethoxy, methoxyethoxy, ethoxyethoxy, methoxy-n-propyloxy. "Alkylthioalkyl" stands for an alkyl thio group bonded via an alkyl group, and "alkylthioalkylthio" means an alkyl thioalkyl group bonded via an oxygen atom. BCS241005-Abroad STR 61 "Arylalkoxyalkyl" stands for an aryloxy residue bound via an alkyl group, and "Heteroaryloxyalkyl" means a heteroaryloxy residue bound via an alkyl group. "Haloalkoxyalkyl" stands for a bound haloalkoxy residue, and "Haloalkylthioalkyl" means a haloalkylthioresidue bound via an alkyl group. "Arylalkyl" stands for an aryl residue bound via an alkyl group, "Heteroarylalkyl" means a heteroaryl residue bound via an alkyl group, and "Heterocyclylalkyl" means a heterocyclyl residue bound via an alkyl group. "Cycloalkylalkyl" stands for a cycloalkyl residue bound via an alkyl group, e.g. B. (but not limited to) cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, 1-cyclopropyleth-1-yl, 2-cyclopropyleth-1-yl, 1-cyclopropylprop-1-yl, 3-cyclopropylprop-1-yl. 15 “Arylalkenyl” refers to an aryl group bound via an alkenyl group, “heteroarylalkenyl” refers to a heteroaryl group bound via an alkenyl group, and “heterocyclylalkenyl” refers to a heterocyclyl group bound via an alkenyl group. “Arylalkynyl” refers to an aryl group bound via an alkynyl group, “heteroarylalkynyl” 20 refers to a heteroaryl group bound via an alkynyl group, and “heterocyclylalkynyl” refers to a heterocyclyl group bound via an alkynyl group. According to the invention, "haloalkylthio" - on its own or as part of a chemical group - stands for straight-chain or branched S-haloalkyl, preferably with 1 to 8, or with 1 to 625 carbon atoms, such as (C1-C8)-, (C1-C6)- or (C1-C4)-Haloalkylthio, e.g. (but not limited to) trifluoromethylthio or trifluoromethylsulfanyl, pentafluoroethylthio or pentafluoroethylsulfanyl, difluoromethyl, 2,2-difluoroeth-1-ylthio, 2,2,2-difluoroeth-1-ylthio, 3,3,3-prop-1-ylthio. “Halocycloalkyl” and “halocycloalkenyl” mean that the haloalkyl group consists of the same or different halogen atoms, such as F, Cl, and Br, or of haloalkyl, such as… B. Trifluoromethyl or difluoromethyl partially or fully substituted cycloalkyl or cycloalkenyl, e.g., 1-fluorocycloprop-1-yl, 2-fluorocycloprop-1-yl, 2,2-difluorocycloprop-1-yl, 1-fluorocyclobut-1-yl, 1-trifluoromethylcycloprop-1-yl, 2-trifluoromethylcycloprop-1-yl, 1-chlorocycloprop-1-yl, 2-chlorocycloprop-1-yl, 2,2-dichlorocycloprop-1-yl, 3,3-difluorocyclobutyl, 35 According to the invention, "trialkylsilyl" or "tris(alkyl)silyl" - on its own or as part of a chemical group - represents straight-chain or branched Si-alkyl, preferably with 1 to 8, or BCS241005-Foreign STR 62 with 1 to 6 carbon atoms, such as Tri-[(C1-C8)-, (C1-C6)- or (C1-C4)-alkyl]silyl, e.g. (but not limited to) trimethylsilyl, triethylsilyl, tri-(n-propyl)silyl, tri-(isopropyl)silyl, tri-(n-butyl)silyl, tri-(1-methylprop-1-yl)silyl, tri-(2-methylprop-1-yl)silyl, tri(1,1-dimethyleth-1-yl)silyl, tri(2,2-dimethyleth-1-yl)silyl. 5 “Trialkylsilylalkynyl” stands for a trialkylsilyl residue bound via an alkynyl group. Synthesis of substituted arylpyrazines of general formula (I): 10 The synthesis of the compounds according to the invention is described below. A central intermediate is represented by compounds of formula (VII), their synthesis is described in detail in WO 2021/069575 and illustrated in Scheme 1. The substituent X1in compounds of formula (II) for chlorine, bromine, or iodine. Compounds of formula (II) are commercially available or can be synthesized by methods well known in the literature. Upon metallation15 of (II) at the ortho position to X1A compound is obtained with intermediate (III) that is in ortho position to X1The intermediate (III) contains a metal fragment M' consisting of a metal such as lithium, magnesium, or zinc, as well as suitable ligands (e.g., 2,2,6,6-tetramethylpiperidide). Subsequently, the intermediate (III) is reacted with an aldehyde (IV). In the resulting alcohol (V), the hydroxyl group is substituted by a protected amine, yielding the intermediate of formula 20 (VII). The substituents PG1and PG2These are amine protecting groups, which can either exist separately or together with the nitrogen atom of the amine, forming a ring. Depending on the reaction method, one or the other type of protecting group is chosen. It is also possible that one of the residues is PG.1or PG2hydrogen. Details of the synthesis of compounds of formula (VII) presented here are given in 25 WO 2021/069575. Scheme 1: 30 An alternative approach to the intermediates (VII) involves, for example, the oxidation of the alcohol (V) to the ketone (VIII), followed by reductive amination to the intermediate (IX). This can be done at BCS241005-Abroad STR 63 Amine can be provided with suitable protection groups, and here too the amine protection groups PG can be used.1and PG2They may be separate from each other or may form a ring together with the nitrogen atom of the amine. Furthermore, one of the PG residues may be1or PG2The hydrogen group is represented by the diagram in Diagram 2. Depending on the conversion method, one or the other of the five protecting groups is chosen. Diagram 2: Diagram 2: 10 Cross-coupling reactions are useful for incorporating the residues M-1, M-2, and M-3, in which the intermediates (VII) are reacted with such reaction partners of formulas (X-1), (X-2), and (X-3) that, according to the definitions of residues M-1, M-2, and M-3, bear a substituted aryl ring (Scheme 3). In the case of substituent X2These are substituents typical for cross-coupling reactions, such as a trialkylstannyl group, a boronic acid, or a boronic ester, or a metal fragment consisting of a metal such as zinc, nickel, or magnesium and suitable ligands. Cross-coupling reactions are typically catalyzed by transition metal catalysts such as palladium or copper with suitable ligands such as phosphines or N-heterocyclic carbenes. Alternatively, the cross-coupling reaction can also be carried out such that the roles of X1and X2are swapped. In this case 20, the cross-coupling reaction would involve substituent X.1For example, it could be a trialkylstannyl group, a boronic acid or a boronic acid ester, or a metal fragment consisting of a metal such as zinc, nickel, or magnesium and suitable ligands – whereby this functionality may need to be produced beforehand, for example, from the corresponding halide. Accordingly, substituent X would be2The leaving group may consist of chlorine, bromine, iodine, or a suitable sulfonate. Cross-coupling reactions of pyrazines are described, for example, in WO 2021069575. Cross-coupling reactions of pyrazines with aryl derivatives are also known in the literature, for example, by W. Verboom et al. in Org. Biomol. Chem., 2013, 11, 3583. In the next step, the amine is deprotected and then acylated. If necessary, the nitrogen atom of the amide group is then further derivatized. The steps of amine deprotection, amine acylation, and amide derivatization are also described, for example, in WO 2021069575. Scheme 3: ≤ ... BCS241005-Abroad STR 64 BCS241005-Abroad STR 65 The esterification to introduce the groups Q-1 to Q-480 and Q-482 to Q-500 defined above can be carried out, as illustrated by way of example but not as a limitation in Scheme 4, starting from the acid function Q-481 in the respective compound of general formula (I), using suitable coupling reagents (e.g. HOBt = 1-hydroxybenzotriazole, EDC = 1-ethyl-3-(3-5-dimethylaminopropyl)carbodiimide, HATU = O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, T3P = 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide) and suitable bases (e.g. diisopropylethylamine, triethylamine) in a suitable Solvents (e.g., dichloromethane, chloroform, acetonitrile) can be used. Alternatively, the esterification can be carried out by transforming group Q-481 in the respective compound of general formula (I) into the acid chloride (XIII-1), (XIII-2), or (XIII-3), for example, using thionyl chloride and subsequent reaction with the corresponding alcohol, using a suitable solvent [e.g., dichloromethane (DCM), chloroform, N,N-dimethylacetamide (DMA), or N,N-dimethylformamide (DMF)]. 15 Scheme 4: (XIII-1) BCS241005-Abroad STR 66 ``` (XIII-3) In one or more reaction steps of the syntheses described in Schemes 3 and 4, the residue 5 Q may need to be modified, because otherwise undesired reactions may occur at residue Q, or because residue Q in certain forms interferes with a desired reaction at another location in the molecule. If necessary, it is advantageous to convert a form Q suitable for the reactions directly or indirectly into the desired form Q at the end of the synthesis sequence. BCS241005-Abroad STR 67 Selected detailed synthesis examples for compounds of the invention of general formula (I) are listed below. The example numbers given correspond to the numbering given in Tables I.1 to I.3 below.1H-NMR-,13C-NMR and19F-NMR spectroscopic data given for the 5 chemical examples described in the following sections, (400 or 600 MHz at1H-NMR and 150 MHz at13C-NMR and 375 MHz at19F-NMR, solvent CDCl3, CD3OD or d6-DMSO, internal standard: tetramethylsilane δ = 0.00 ppm), were obtained using a Bruker instrument, and the signals indicated have the following meanings: br = broad; s = singlet, d = doublet, t = triplet, dd = double doublet, ddd = doublet of a double doublet, m = multiplet, q = 10 quartet, quint = quintet, sext = sextet, sept = septet, dq = double quartet, dt = double triplet. For diastereomeric mixtures, either the significant signals of both diastereomers or the characteristic signal of the main diastereomer are given. The abbreviations used for chemical groups have, for example, the following meanings: Me = CH3, Et or Ethyl = CH2CH3, t-Hex = C(CH3)2CH(CH3)2, t-Bu = C(CH3)3n-Bu = unbranched butyl, n-Pr or Prop-1-yl 15 = unbranched propyl, i-Pr or Prop-2-yl = branched propyl, c-Pr = cyclopropyl, c-Bu = cyclobutyl, c-Hex = cyclohexyl. Synthesis examples: 20 No. I.1-35: (rac)-Methyl-4-(3-{1-[3-chloro-5-(trifluoromethoxy)benzamido]ethyl}pyrazin-2-yl)benzoate Synthesis step 1: 1-(3-Bromopyrazin-2-yl)ethanone Diisopropylamine (73.2 g, 723 mmol, 102 mL, 2.30 equivalents) was dissolved in THF (350 mL) at -78 °C under an argon atmosphere of 25. n-BuLi (2.50 M, 277 mL, 2.20 equivalents) was slowly added dropwise to the solution at -78 °C. The reaction mixture was then warmed to -30 °C and stirred for 30 minutes at this temperature. The mixture was then cooled again to -78 °C. Bromopyrazine (50.0 g, 315 mmol, 1.00 equivalent), dissolved in THF (300 mL), was added dropwise to the mixture over 30 minutes at -78 °C. N-Methoxy-N-methylacetamide (48.7 g, 472 mmol, 30, 50.2). mL, 1.50 eq.) was then slowly added dropwise to the reaction mixture at -78 °C. The reaction mixture was stirred for 1 hour at -70 °C. Thin-layer chromatography showed that 2-bromopyrazine was completely consumed and a new spot had formed. The reaction mixture was poured into a mixture of ice and a saturated NH4Cl solution (1000 mL), and the aqueous phase was extracted three times with ethyl acetate (300.0 mL each). The combined BCS241005-Abroad STR 68 organic phases were washed with a saturated saline solution (300 ml) and anhydrous Na.2SO4The residue was dried, filtered, and concentrated under vacuum. It was purified by column chromatography (SiO2, petroleum ether/ethyl acetate = 10:1 to 3:1). 1-(3-Bromopyrazin-2-yl)ethanone (35.0 g, 174 mmol, 55.4% yield) was obtained as a yellow solid.1H NMR (400 5 MHz, CDCl3) δ in ppm: 8.69 - 8.53 (m, 1H), 8.47 (d, J = 2.2 Hz, 1H), 2.84 - 2.56 (m, 3H). Synthesis step 2: Methyl 4-(3-acetylpyrazin-2-yl)benzoate A solution of 1-(3-bromopyrazin-2-yl)ethanone (66.2 g, 329 mmol, 1.00 equivalents) in dioxane (330 10 ml) and water (66 ml) was reacted with K under a nitrogen atmosphere.3PO4(139 g, 658 mmol, 2.00 equivalents) and [4-(Methoxycarbonyl)phenyl]boronic acid (65.2 g, 362 mmol, 1.10 eq.) and Pd(dppf)Cl2(24.1 g, 32.9 mmol, 0.100 eq.). The reaction mixture was stirred for 16 hours at 100 °C. TLC (petroleum ether:ethyl acetate = 5:1, Rf = 0.25) showed that 1-(3-bromopyrazin-2-yl)ethanone was completely consumed and a new spot had formed. Reaction mixture 15 was diluted with 200 ml of water and extracted three times with ethyl acetate (200 ml each). The combined organic phases were washed with a saturated sodium chloride solution (200 ml), over Na2SO4The residue was dried, filtered, and concentrated under reduced pressure. It was purified by column chromatography (SiO2, petroleum ether/ethyl acetate = 10:1 to 4:1). Methyl 4-(3-acetylpyrazin-2-yl)benzoate (75.0 g, 292 mmol, 88.8% yield) was obtained as a yellow solid.1H NMR (400 MHz, CDCl3) δ in ppm: 8.76 (br s, 1H), 8.61 (br s, 1H), 8.23 - 8.02 (m, 2H), 7.75 - 7.54 (m, 2H), 3.95 (s, 3H), 2.70 (d, J = 1.5 Hz, 3H). Synthesis step 3: (rac)-methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate 25 To a solution of (rac)-methyl-4-(3-acetylpyrazin-2-yl)benzoate (70.0 g, 273 mmol, 1.00 eq.) and NH4OAc (126 g, 1.64 mol, 6.00 eq.) in MeOH (350 ml) at 20 °C, stirred for 1 hour at 20 °C, NaBH₄3CN (68.6 g, 1.09 mol, 4.00 equivalents) in NH3^H2O (117 ml) was added. The mixture was stirred for 16 hours at 55 °C. The reaction solution was heated under reduced BCS241005-Abroad STR 69 concentrated pressure. (rac)-Methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate (75.0 g, crude) was obtained as a yellow oil (75.0 g, crude) and used in the next synthesis step without further purification. Synthesis step 4: (rac)-Methyl-4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoate 5 Triethylamine (55.0 g, 544 mmol, 75.7 ml, 2.00 eq.) was added to a solution of methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate (70.0 g, 272 mmol, 1.00 eq.) in THF (350 ml), followed by Boc.2O (71.2 g, 326 mmol, 75.0 ml, 1.20 eq.) was added dropwise. The mixture was stirred for 16 hours at 20 °C. The reaction mixture was then diluted with 200 ml of water and extracted three times with ethyl acetate (200 ml each). The combined organic phases were washed with saturated sodium chloride (200 ml) and purified over Na2SO4The residue was dried, filtered, and concentrated under reduced pressure. It was then analyzed by column chromatography (SiO₂).2, Petroleum ether/ethyl acetate = 5/1 to 0/1). (rac)-Methyl-4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoate (45.0 g, 125 mmol, 46.2% yield) was obtained as a yellow solid.1H NMR (400 MHz, CDCl3) δ in ppm: 8.83 - 8.47 (m, 15 2H), 8.19 (d, J = 8.1 Hz, 2H), 7.71 (br d, J = 7.8 Hz, 2H), 5.77 - 5.46 (m, 1H), 5.32 - 5.00 (m, 1H), 3.97 (s, 3H), 1.57 - 1.35 (m, 9H), 1.29 (br d, J = 6.1 Hz, 3H). Synthesis step 5: (rac)-methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate hydrochloride 20. HCl/dioxane (4 M, 421 ml, 1.00 eq.) was added to a solution of (rac)-methyl-4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoate (42.1 g, 118 mmol, 1.00 eq.) in DCM (200 ml). The crude product was triturated with ethyl acetate for 0.5 hours at 25 °C. (rac)-methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate hydrochloride (33.3 g, 96.3% yield) was obtained as a cream-colored solid. ``` BCS241005-Ausland STR 70 1H NMR (400 MHz, DMSO-d6) δ in ppm: 8.87-8.77 (m, 2H), 8.69-8.42 (m, 3H), 8.14 (d, J = 8.1 Hz, 2H), 7.78 (d, J = 8.1 Hz, 2H), 4.58-4.48 (m, 1H), 3.91 (s, 3H), 1.42 (d, J = 6.6 Hz, 3H). Synthesis step 6: No. I.1-35, (rac)-methyl-4-(3-{1-[3-chloro-5-5(trifluoromethoxy)benzamido]ethyl}pyrazin-2-yl)benzoate 3-chloro-5-(trifluoromethoxy)benzoic acid (703 mg, 2.92 mmol) was added to a stirred suspension of (rac)-methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate hydrochloride (0.78 g, 2.66 mmol) in dichloromethane (20 ml), followed by 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride (611 mg, 3.19 mmol) and 1-hydroxybenzotriazole hydrate (430 mg, 14 wt%).2O, 2.74 mmol). Triethylamine (1.11 ml, 7.97 mmol) was added, whereupon the reaction mixture became homogeneous. The reaction mixture was stirred overnight at room temperature. Subsequently, a saturated aqueous sodium bicarbonate solution was added to the reaction mixture, the resulting phases were separated, and the aqueous phase was extracted once with dichloromethane. The combined organic phases 15 were concentrated under vacuum, and the resulting crude product was purified by chromatography over silica gel using a gradient of heptane and 0–75% ethyl acetate to give (rac)-methyl-4-(3-{1-[3-chloro-5-(trifluoromethoxy)benzamido]ethyl}pyrazin-2-yl)benzoate (1.11 g, >99% purity, 87% yield) as a white solid.1H NMR (400 MHz, DMSO-d6) δ in ppm: 9.15 (d, J = 6.5 Hz, 1H), 8.70–8.66 (m, 2H), 8.08–8.05 (m, 2H), 7.92–7.92 (m, 1H), 7.80–7.79 20 (m, 2H), 7.75–7.74 (m, 1H), 7.69–7.68 (m, 1H), 5.34–5.28 (m, 1H), 3.89 (s, 3H), 1.47 (d, J = 6.8 Hz, 3H). No. I.1-36: (rac)-4-(3-{1-[3-chloro-5-(trifluoromethoxy)benzamido]ethyl}pyrazin-2-yl)benzoic acid BCS241005-Abroad STR 71 ``` To a stirred solution of (rac)-methyl-4-(3-{1-[3-chloro-5-(trifluoromethoxy)benzamido]-ethyl}pyrazin-2-yl)benzoate (0.43 g, 0.90 mmol) in THF (8 ml) and water (4 ml), LiOH (64 mg, 2.67 mmol) was added, and the reaction mixture was stirred overnight at room temperature. The reaction was then acidified to a pH of 1 to 2 with an aqueous 2 M hydrochloric acid solution and extracted with ethyl acetate. The organic extract was washed with saline solution, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum to give the (rac)-4-(3-{1- [3-Chloro-5-(trifluoromethoxy)benzamido]ethyl}pyrazin-2-yl)benzoic acid (0.41 g, >99 % purity, 98 % yield) as a white solid.1H NMR (400 MHz, DMSO-d6) δ in ppm: 13.10 (brs, 1H), 10 9.18 (d, J = 6.7 Hz, 1H), 8.69–8.66 (m, 2H), 8.07–8.04 (m, 2H), 7.95–7.94 (m, 1H), 7.79–7.74 (m, 3H), 7.72–7.71 (m, 1H), 5.35–5.28 (m, 1H), 1.47 (d, J = 7.0 Hz, 3H). No. I.1-42: (rac)-Pyridin-2-ylmethyl-4-(3-{1-[3,5-bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoate 15 A solution of 2,2,6,6-tetramethylpiperidine (1.50 eq) in absolute tetrahydrofuran (1 mL/mmol) was cooled to -78 °C under an argon atmosphere and treated dropwise with a solution of n-butyllithium in absolute hexane (2.5 M, 1.30 eq). The resulting reaction mixture was stirred for 30 minutes at -30 °C, cooled again to -78 °C, and treated dropwise with a solution of 2-bromopyrazine (1.00 eq) in absolute tetrahydrofuran (0.5 mL/mmol). The resulting reaction mixture was then stirred for 30 minutes at -78 °C, after which a solution of acetaldehyde (2.00 eq) in absolute tetrahydrofuran (0.5 mL/mmol) was added dropwise. Tetrahydrofuran (0.5 mL/mmol), and the resulting reaction mixture was incubated for 60 minutes. ... BCS241005-Abroad STR 72 long stirred at a temperature of -78 °C. After complete conversion (thin-layer chromatography and LC-MS control), the reaction mixture was treated with aqueous NH₃.4The mixture was treated with chlorine solution and thoroughly extracted several times with EtOAc. The combined organic phases were washed with saturated NaCl solution and rinsed over Na2SO4The mixture was dried, filtered, and concentrated under reduced pressure (5°C). The remaining residue was purified by column chromatography (SiO₂).2Petroleum ether/ethyl acetate (5:1 to 20:1) and 1-(3-bromopyrazin-2-yl)ethanol were obtained as a dark yellow oil. 1-(3-bromopyrazin-2-yl)ethanol (1.00 eq) was dissolved in absolute tetrahydrofuran (1.5 mL/mmol), mixed with isoindoline-1,3-dione (1.00 eq) and triphenylphosphine (1.50 eq), stirred for 10 minutes at room temperature, and cooled to 0 °C. Then, 10 eq of diisopropyl azodicarboxylic acid ester (1.50 eq) were added. After complete conversion upon heating to room temperature (reaction monitored by thin-layer chromatography), the reaction mixture was filtered and concentrated under reduced pressure. The remaining residue (SiO₂) was purified by column chromatography.2In a gradient hexane/ethyl acetate reaction, 2-[3-(1-hydroxyethyl)pyrazin-2-yl]-1H-isoindole-1,3(2H)-dione was obtained as a colorless solid. In the next step, 2-15[3-(1-hydroxyethyl)pyrazin-2-yl]-1H-isoindole-1,3(2H)-dione (1.00 eq) was dissolved in abs. MeOH and hydrazine hydrate (5.00 eq) was added dropwise at room temperature. The resulting reaction mixture was stirred under reflux conditions for 1 h, and after complete conversion (reaction monitored by LC-MS), the mixture was carefully concentrated under reduced pressure and stored without further purification in a mixture of tetrahydrofuran and H₂.2O (1:1) solved. 20 Then Na2CO3(3.00 eq) and Boc2O₂ (5.00 eq) was added and the resulting reaction mixture was stirred for 12 h at room temperature. After complete conversion (reaction control by LC-MS), the reaction mixture was thoroughly extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), and rinsed over Na₂.2SO4Dried, filtered, and concentrated under reduced pressure. Purification of the remaining 25 residue (SiO₂) by column chromatography.2From a solution of petroleum ether/ethyl acetate (5:1 to 20:1), tert-butyl-[1-(3-bromopyrazin-2-yl)ethyl]carbamate was obtained as a colorless solid. A solution of methyl 4-bromobenzoate (1.00 eq) was dissolved in absolute dioxane in a heated round-bottom flask under argon and reacted with hexamethyldistannan (1.00 eq) and Pd(PPh₂).3)4(1 equiv). The resulting reaction mixture was stirred for 12 h at a temperature of 90 °C and, after cooling to room temperature, filtered through Celite for 30 minutes, washed with ethyl acetate, and concentrated under reduced pressure. The remaining residue (SiO₂) was purified by column chromatography.2From a gradient of heptane/ethyl acetate, methyl 4-(trimethylstannyl)benzoate was obtained as a slightly yellowish, viscous oil. tert-Butyl-[1-(3-bromopyrazin-2-yl)ethyl]carbamate (1.00 eq) was dissolved in absolute toluene in a heated round-bottom flask under argon and reacted with methyl 4-(trimethylstannyl)benzoate (1.00 eq) 35 and Pd(PPh₂).3)4(0.40 eq). The resulting reaction mixture was stirred under reflux conditions in argon for 14 h. The reaction progress was monitored by LCMS, and after complete conversion of the starting materials, the reaction mixture was tested for BCS241005-Abroad STR 73 Cooled to room temperature, extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), rinsed over Na2SO4Dried, filtered, and concentrated under reduced pressure. Purification of the remaining residue (SiO₂) by column chromatography.2From a gradient of n-heptane/ethyl acetate, methyl 4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoate was obtained as a pale yellow solid. Methyl 4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoate (1.00 eq) was then dissolved in HCl/dioxane and dichloromethane and stirred at room temperature for 12 h. The reaction mixture was then concentrated under reduced pressure, and the remaining residue of ethyl acetate (50.0 mL) was recrystallized. In this way, methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate was obtained in the form of a yellowish solid (86% of theory). Methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate can also exist in the form of its HCl salt and be used as such in subsequent steps and released by the base used, e.g., triethylamine. Methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate (2000 mg, 7.77 mmol, 1.00 eq) was dissolved under argon in a heated round-bottom flask in absolutes. Dichloromethane (50 mL) was dissolved and, after stirring for 5 minutes at room temperature, treated with triethylamine 15 (2.71 mL, 19.40 mmol, 3.0 eq), 3,5-bis(trifluoromethyl)benzoic acid (2006 mg, 7.77 mmol, 1.00 eq), and 50% propanephosphonic anhydride in tetrahydrofuran (5.78 mL, 9.71 mmol, 1.5 eq). The resulting reaction mixture was stirred for 14 h at room temperature, then treated with dichloromethane and washed with dilute HCl (1 M). The organic phase was dried over sodium sulfate, filtered, and concentrated under reduced pressure. Methyl 4-(3-{1-[3,5-bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoate (I.1-1) was obtained as a colorless solid (1240 mg, 32% of theory) by column chromatographic purification of the crude product (gradient heptane/ethyl acetate) 20. In the next step, methyl 4-(3-{1-[3,5-bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoate (1200 mg, 2.41 mmol, 1.00 eq) was dissolved in a mixture of tetrahydrofuran and water (1:1) and treated with sodium hydroxide solution (4 M, 9.65 mmol, 4.00 eq) 25. The resulting reaction mixture was then stirred overnight at room temperature, concentrated under reduced pressure, acidified with dilute HCl (10%), and treated with ethyl acetate. The aqueous phase was thoroughly extracted with ethyl acetate, and the combined organic phases were dried over magnesium sulfate, filtered, and concentrated under reduced pressure. Column chromatographic purification of the crude product (gradient heptane/ethyl acetate) yielded 4-(3-{1-30[3,5-Bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoic acid (I.1-2) as a colorless solid (1000 mg, 86% of theory). 4-(3-{1-[3,5-Bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoic acid (120 mg, 0.24 mmol, 1.0 eq), 1-hydroxybenzotriazole (42 mg, 0.31 mmol, 1.3 eq), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (60 mg, 0.31 mmol, 1.3 eq) were obtained in abs. Dichloromethane (5 mL) was dissolved and, after stirring for 535 minutes at room temperature, triethylamine (0.10 mL, 0.72 mmol, 3.0 equiv) and 2-hydroxymethylpyridine (0.06 mL, 0.31 mmol, 1.3 eq) were added. The resulting reaction mixture was stirred for 6 h at room temperature, then treated with water and dichloromethane. BCS241005-Abroad STR 74 was thoroughly extracted. The combined organic phases were dried over magnesium sulfate, filtered, and concentrated under reduced pressure. Column chromatographic purification of the crude product (gradient heptane/ethyl acetate) yielded (rac)-pyridin-2-ylmethyl-4-(3-{1-[3,5-bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoate (I.1-42) as a colorless solid 5 (87 mg, 59% of theory).1H-NMR (400 MHz, CDCl3): Peak picking δ= 8.6652 (8.1); 8.6469 (4.1); 8.6371 (4.2); 8.6090 (7.5); 8.3224 (7.8); 8.3029 (8.6); 8.2499 (14.7); 8.0154 (6.8); 7.7731 (9.9); 7.7533 (11.3); 7.5039 (4.6); 7.4830 (4.7); 7.4538 (2.7); 7.2874 (2.5); 7.2626 (19.9); 5.7156 (2.1); 5.6973 (3.2); 5.6803 (2.1); 5.5829 (0.8); 5.5430 (13.0); 5.5074 (0.8); 5.2997 (5.1); 4.1463 (0.6); 4.1305 (1.5); 4.1132 (1.5); 4.0947 (0.5); 2.1192 (0.6); 2.0450 (6.4); 1.6096 (16.0); 1.4543 (12.6); 1.4374 (12.8); 1.2772 (2.5); 1.2592 (5.6); 1.2415 (2.2); 0.8799 (1.0); -0.0002 (20.2). No. I.1-81: (+)-Pyridin-2-ylmethyl-4-(3-{1-[3,5-bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoate and No. I.1-82: (-)-Pyridin-2-ylmethyl-4-(3-{1-[3,5-bis(trifluoromethyl)benzamido]ethyl}- pyrazin-2-yl)benzoate 15 The esterification of (I.1-2) described above was repeated on an enlarged scale (1.54 mmol). The racemic pyridin-2-ylmethyl-4-(3-{1-[3,5-20 bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoate (I.1-42) (400 mg) obtained in this way was then separated into its enantiomers using a chiral preparative SFC system with an S10 chiralpak IF-B1 column (gradient Chir_C4_IF_B1_90CO2_MeOH_CD). I.1-81 (Ent-1, 135 mg, retention time 1.41 min, specific rotation +123.30°) and I.1-82 (Ent-2, 145 mg, retention time 1.48 min, specific rotation -115.30°) were isolated as colorless solids. I.1-81:1H-NMR 25 (400 MHz, CDCl3): ^ 8.68 (s, 1H). 8.67-8.64 (m, 1H), 8.62 (s, 1H), 8.33-8.30 (d, 2H), 8.25 (s, 2H), 8.02 (s, 1H), 7.79-7.75 (m, 3H), 7.52-7.50 (d, 1H), 7.47-7.45 (d, 1H), 7.30-7.27 (m, 1H), 5.73-5.66 (quint, 1H), 5.59-5.55 (d, 1H), 5.56-5.52 (d, 1H), 1.46-1.44 (d, 3H). I.1-82: 1H-NMR (400 MHz, CDCl3): ^ 8.69 (s, 1H). 8.67-8.64 (m, 1H), 8.63 (s, 1H), 8.32-8.30 (d, 2H), 8.25 (s, 2H), 8.02 (s, 1H), 7.80-7.75 (m, 3H), BCS241005-Abroad STR 75 7.52-7.50 (d, 1H), 7.47-7.45 (d, 1H), 7.30-7.27 (m, 1H), 5.73-5.66 (quint, 1H), 5.59-5.55 (d, 1H), 5.56- 5.52 (d, 1H), 1.46-1.44 (d, 3H). No. I.1-68: (rac)-Methyl-4-{3-[1-(3,4-dichlorobenzamido)ethyl]pyrazin-2-yl}benzoate 5 10 Methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate (200 mg, 0.78 mmol, 1.00 eq) was reacted with triethylamine (0.33 mL, 2.33 mmol, 3.0 eq) in absolute dichloromethane (3 mL) at room temperature. The reaction mixture was then cooled to a temperature of 0–5 °C. A solution of 3,4-dichlorobenzoyl chloride (171 mg, 0.82 mmol, 1.05 eq) in a small amount of dichloromethane was then added dropwise over five minutes. The resulting reaction mixture was stirred at room temperature for 16 h. For work-up, the reaction mixture was concentrated under reduced pressure. By column chromatographic purification20 of the crude product (gradient heptane/ethyl acetate) (rac)-methyl-4-{3-[1-(3,4-dichlorobenzamido)ethyl]pyrazin-2-yl}benzoate (I.1-68) was obtained (212 mg, 63% of theory).1H- NMR(400.6 MHz, CDCl3): δ= 8.6450 (2.7); 8.6390 (3.2); 8.5909 (3.0); 8.5849 (2.4); 8.2296 (3.6); 8.2086 (3.9); 7.9060 (2.8); 7.9009 (2.8); 7.7410 (3.9); 7.7201 (3.6); 7.6504 (1.3); 7.6453 (1.2); 7.6296 (1.8); 7.6245 (1.7); 7.5309 (3.1); 7.5102 (2.2); 7.3202 (0.8); 7.3014 (0.8); 7.2619 (8.5); 5.6706 (0.9); 25 5.6533 (1.1); 5.6346 (0.8); 3.9722 (16.0); 1.6082 (0.6); 1.4085 (6.2); 1.3918 (6.1); -0.0002 (9.7) No. I.1-66: (rac)-4-{3-[1-(3,4-dichlorobenzamido)ethyl]pyrazin-2-yl}benzoic acid 30 35 BCS241005-Abroad STR 76 Methyl 4-{3-[1-(3,4-dichlorobenzamido)ethyl]pyrazin-2-yl}benzoate (I.1-68) (1.36 g, 3.16 mmol, 1.00 eq) was reacted with sodium hydroxide solution (5.00 mL, 20 wt%, 31.6 mmol, 10.0 eq) in methanol (50 mL). The reaction mixture was then stirred for 1 h at a temperature of 60 °C. For work-up, the reaction mixture was concentrated under reduced pressure. The residue was dissolved in a small amount of water for 5 minutes, and the mixture was then acidified with 6 N hydrochloric acid. The precipitated solid was separated and dried. For further purification, the solid was stirred with n-heptane, and after filtration, the solid was dried. (rac)-4-{3-[1-(3,4-Dichlorobenzamido)ethyl]pyrazin-2-yl}benzoic acid (I.1-66) was obtained (1.21 g, 92% of theory). 1H-NMR (400.6 MHz, d6-DMSO): δ= 9.0810 (3.5); 9.0645 (3.6); 8.6659 (7.5); 8.6598 (13.6); 8.6466 10 (16.0); 8.6406 (9.2); 8.0710 (9.7); 8.0660 (9.7); 8.0489 (11.0); 8.0444 (3.5); 8.0325 (3.9); 8.0278 (13.0); 8.0238 (1.9); 7.9569 (0.5); 7.9523 (0.6); 7.7942 (4.5); 7.7891 (4.0); 7.7833 (0.5); 7.7733 (7.2); 7.7681 (7.3); 7.7581 (0.7); 7.7453 (10.5); 7.7408 (3.5); 7.7288 (3.5); 7.7244 (9.4); 7.7157 (13.2); 7.6948 (7.8); 5.3296 (2.4); 5.3127 (3.6); 5.2958 (2.3); 3.3327 (2.6); 3.1689 (0.6); 2.6758 (1.0); 2.6711 (1.5); 2.6666 (1.0); 2.6620 (0.5); 2.5417 (3.7); 2.5376 (0.7); 2.5327 (1.1); 2.5249 (4.5); 2.5202 (6.1); 2.5115 (80.2); 2.5069 (173.8); 2.5023 (241.9); 2.4978 (165.0); 2.4932 (71.4); 2.3340 (1.0); 2.3294 (1.4); 2.3247 (1.0); 1.4550 (14.1); 1.4378 (14.0); 0.1456 (0.6); 0.0080 (5.5); 0.0062 (1.4); -0.0002 (200.7); -0.0051 (1.7); -0.0060 (1.4); -0.0069 (1.3); -0.0085 (5.4); -0.1493 (0.6). No. I.1-169: (rac)-2-Methoxyethyl-4-{3-[1-(3,4-dichlorobenzamido)ethyl]pyrazin-2-yl}benzoate 20 25 4-{3-[1-(3,4-Dichlorobenzamido)ethyl]pyrazin-2-yl}benzoic acid (I.1-66) (200 mg, 0.48 mmol, 1.00 eq) was reacted in dichloromethane (20 mL) with 1-hydroxybenzotriazole (84.4 mg, 0.625 mmol, 1.30 eq), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (120 mg, 0.625 mmol, 1.30 eq), and 4-30-dimethylaminopyridine (0.587 mg, 0.005 mmol, 0.01 eq). Subsequently, 2-methoxyethanol (51.2 mg, 0.673 mmol, 1.40 eq) was added. The reaction mixture was then stirred for 16 h at room temperature. For work-up, the mixture was stirred with water, and after phase separation, the organic phase was concentrated under reduced pressure. Due to incomplete reaction, no pure product could be isolated after column chromatographic purification of the crude product. To complete the reaction, the mixture obtained after column chromatographic purification was reacted in dichloromethane (20 mL) with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (120 mg, 0.625 mmol, 1.30 eq) and triethylamine (97.2 mg/mol).BCS241005-Ausland STR 77 mg (0.961 mmol, 2.00 eq) was added. Subsequently, 2-methoxyethanol (51.2 mg, 0.673 mmol, 1.40 eq) was added. The reaction mixture was then stirred for 16 h at room temperature. For work-up, the reaction mixture was stirred with water, and after phase separation, the organic phase was freed from the solvent under reduced pressure. By column chromatographic purification of the crude product (gradient heptane/ethyl acetate), (rac)-2-methoxyethyl-4-{3-[1-(3,4-dichlorobenzamido)ethyl]pyrazin-2-yl}benzoate (I.1-169) was obtained (108 mg, 47% of theory).1H-NMR (400.6 MHz, CDCl3): δ= 8.6457 (1.0); 8.6396 (1.3); 8.5899 (1.1); 8.5838 (0.9); 8.2588 (1.2); 8.2376 (1.5); 7.9074 (1.0); 7.9023 (1.1); 7.7420 (1.3); 7.7208 (1.3); 7.6301 (0.7); 7.6249 (0.7); 7.5326 (1.2); 7.5119 (0.9); 7.2606 (24.5); 4.5384 (0.6); 4.5294 (0.7); 4.5244 (0.7); 4.5151 10 (0.6); 3.7754 (0.9); 3.7635 (1.0); 3.7518 (0.9); 3.4588 (7.8); 2.0455 (0.6); 1.5475 (16.0); 1.4014 (2.1); 1.3847 (2.2); 0.0079 (0.9); -0.0002 (29.0); -0.0085 (1.0). No. I.1-177: (rac)-Isopropyl-4-{3-[1-(3,4-dichlorobenzamido)ethyl]pyrazin-2-yl}benzoate 15 20 4-{3-[1-(3,4-Dichlorobenzamido)ethyl]pyrazin-2-yl}benzoic acid (I.1-66) (150 mg, 0.36 mmol, 1.00 eq) was reacted with 1-hydroxybenzotriazole (63.3 mg, 0.468 mmol, 1.30 eq) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (89.8 mg, 0.468 mmol, 1.30 eq) in dichloromethane (20 mL). The reaction mixture was then stirred for 15 minutes at room temperature. Subsequently, 25 doses of 2-propanol (30.3 mg, 0.504 mmol, 1.40 eq) and triethylamine (72.9 mg, 0.721 mmol, 2.00 eq) were added successively. The reaction mixture was then stirred for 16 h at room temperature. To complete the reaction, 2-propanol (30.3 mg, 0.504 mmol, 1.40 eq) and triethylamine (72.9 mg, 0.721 mmol, 2.00 eq) were added again, and the mixture was stirred once more for 16 h at room temperature. Since the analytical reaction control still did not indicate complete conversion, 2-propanol (30.3 mg, 0.504 mmol, 1.40 eq) and triethylamine (72.9 mg, 0.721 mmol, 2.00 eq) were added again. The mixture was then stirred under reflux for 1 hour and subsequently for five days at room temperature. For work-up, the mixture was stirred with water, and after phase separation, the organic phase was concentrated under reduced pressure. After column chromatographic purification of the crude product (heptane/ethyl acetate gradient), the residue was dissolved in acetone, and the mixture was then concentrated again under reduced pressure until dry. (rac)-Isopropyl-4-{3-[1-(3,4-dichlorobenzamido)ethyl]pyrazin-2-yl}benzoate (I.1-177) was obtained (107 mg, 65% of theory).1H- ... BCS241005-Abroad STR 78 NMR (400.6 MHz, CDCl3): δ= 8.6478 (2.4); 8.6419 (2.9); 8.5873 (2.7); 8.5815 (2.4); 8.2266 (3.3); 8.2061 (3.8); 7.9079 (2.5); 7.9033 (2.8); 7.7268 (3.6); 7.7062 (3.5); 7.6515 (1.2); 7.6467 (1.2); 7.6308 (1.6); 7.6259 (1.7); 7.5309 (2.7); 7.5102 (2.0); 7.3166 (1.0); 7.2974 (1.0); 7.2610 (12.4); 5.6756 (0.8); 5.6565 (1.2); 5.6390 (0.9); 5.3179 (1.0); 5.3022 (1.3); 5.2866 (1.0); 2.0454 (1.5); 1.5942 (2.4); 1.4152 (14.3); 1.3997 (16.0); 1.3881 (6.7); 1.3029 (1.0); 1.2634 (4.7); 1.2420 (1.2); 0.8972 (1.9); 0.8818 (4.7); 0.8641 (2.2); -0.0002 (17.8). No. I.1-284: Methyl 4-(3-{[3,5-bis(trifluoromethyl)benzamido](cyclopropyl)methyl}pyrazin-2-yl)benzoate 10 Synthesis step 1: (3-bromopyrazin-2-yl)(cyclopropyl)methanol A solution of N-isopropylpropan-2-amine (58.6 g, 579 mmol, 82 mL, 2.30 eq) in absolute tetrahydrofuran (280 mL) was cooled to -78 °C under an argon atmosphere and treated dropwise with a solution of n-butyllithium in absolute tetrahydrofuran (2.5 M, 221 mL, 2.20 eq). The resulting reaction mixture was stirred for 30 minutes at -30 °C, cooled again to -78 °C, and treated dropwise with a solution of 2-bromopyrazine (40.0 g, 252 mmol, 1.00 eq) in absolute tetrahydrofuran (120 mL). The resulting reaction mixture was then stirred for 30 minutes at a temperature of -78 °C, followed by the dropwise addition of a solution of cyclopropanecarbaldehyde (35.3 g, 503 mmol, 37.6 mL, 2.20 eq) in abs. tetrahydrofuran (40.0 20 mL), and the reaction mixture was stirred for 60 minutes at a temperature of -78 °C. After complete conversion (thin-layer chromatography and LC-MS control), the reaction mixture was dissolved with aqueous NH₃.4The mixture was treated with Cl solution (500 mL) and extracted several times with EtOAc (200 mL x 3). The combined organic phases were washed with saturated NaCl solution (200 mL), then purged with Na2SO4The mixture was dried, filtered, and concentrated under reduced pressure. The remaining residue was purified by column chromatography (SiO₂).2Petroleum ether/ethyl acetate (5:1 to 20:1) and (3-bromopyrazin-2-yl)(cyclopropyl)methanol (45.0 g, 78% of theory) were obtained as a yellowish oil. Synthesis step 2: 3-bromopyrazin-2-yl)(cyclopropyl)methanone 30 (3-Bromopyrazin-2-yl)(cyclopropyl)methanol (45.0 g, 196 mmol, 1.00 eq) was dissolved in absolute dichloromethane (315 mL), treated with pyridinium chlorochromate (PCC, 84.7 g, 393 mmol, 2.00 eq) and incubated for 12 h.BCS241005-Ausland STR 79 was stirred at room temperature. After complete conversion (reaction control via thin-layer chromatography), the reaction mixture was filtered and concentrated under reduced pressure. The remaining residue (SiO₂) was purified by column chromatography.2, Petroleum ether/ethyl acetate = 5/1 to 20/1) yielded 3-bromopyrazin-2-yl)(cyclopropyl)methanone (24.0 g, 54% of theory) in the form of a yellow solid.1H-NMR (400 MHz, CDCl3): δ (ppm) = 8.51-8.55 (m, 1H) 8.38-8.42 (m, 1H) 2.76-2.85 (m, 1H), 1.29 (m, 2H), 1.06-1.14 (m, 2H). Synthesis step 3: tert-Butyl-[(3-bromopyrazin-2-yl)(cyclopropyl)methyl]carbamate 10 In the next step, ammonium acetate (91.7 g, 1.19 mol, 15.0 eq) was added to a solution of 3-bromopyrazin-2-yl)(cyclopropyl)methanone (18.0 g, 79.3 mmol, 1.00 eq) in abs. MeOH (126 mL) at room temperature. The resulting reaction mixture was stirred for 2 h at a temperature of 60 °C, then treated with NaBH₄.3CN (49.8 g, 793 mmol, 10.0 eq) was added and stirred for 10 h at a temperature of 60°C. After complete conversion (reaction control by LC-MS), the reaction mixture was concentrated under reduced pressure and the resulting 1-(3-bromopyrazin-2-yl)-1-cyclopropylmethanamine (18.0 g, 78.9 mmol, 1.00 eq), obtained as a yellow solid, was used in the next reaction step without further purification in a mixture of tetrahydrofuran (36.0 mL) and H2O (54.0 mL) dissolved. Then Na2CO3 (25.1 g, 237 mmol, 3.00 eq) and Boc2O₂ (25.8 g, 118 mmol, 1.50 eq) was added and the resulting reaction mixture was stirred for 12 h at room temperature. After complete conversion (reaction control by LC-MS), the reaction mixture was thoroughly extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), and rinsed over Na₂O.2SO4Dried, filtered, and concentrated under reduced pressure. Purification of the remaining residue (SiO₂) by column chromatography.2From a mixture of petroleum ether and ethyl acetate (5/1 to 20/1), tert-butyl-[(3-bromopyrazin-2-yl)(cyclopropyl)methyl]carbamate (11.0 g, 43% of theory) was obtained as a colorless solid. Synthesis step 4: Methyl-4-(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)methyl}pyrazin-2-yl)benzoate BCS241005-Ausland STR 80 tert-butyl-[(3-bromopyrazin-2-yl)(cyclopropyl)methyl]carbamate (10.0 g, 30.5 mmol, 1.00 eq), methyl 4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzoate (11.9 g, 45.7 mmol, 1.50 eq), K2CO3(8.42 g, 60.9 mmol, 2.00 eq) and Pd(dppf)Cl2(2.23 g, 3.05 mmol, 0.100 eq) were dissolved under argon in abs. dioxane (50.0 mL) and H2O₂ (10.0 mL) was dissolved, and the resulting reaction mixture was stirred under argon at a temperature of 5–100 °C for 12 h. The reaction progress was monitored by LC-MS, and after complete conversion of the starting materials, the reaction mixture was cooled to room temperature, extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), and rinsed over Na₂O.2SO4Dried, filtered, and concentrated under reduced pressure. Purification of the remaining residue (SiO₂) by column chromatography.2From a reaction of petroleum ether/ethyl acetate (5/1 to 20/1), methyl 4-10(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)methyl}pyrazin-2-yl)benzoate (11.0 g, 94% of theory) was obtained as a yellowish solid. Synthesis step 5: Methyl 4-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoate 15 Methyl-4-(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)-methyl}pyrazin-2-yl)benzoate (4.00 g, 10.4 mmol, 1.00 eq) was then dissolved in HCl/dioxane (4.00 mL) and dichloromethane (20.0 mL) and stirred for 12 h at room temperature. The reaction mixture was then concentrated under reduced pressure and the remaining residue was recrystallized from ethyl acetate (50.0 mL). In this way, methyl-4-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoate (3.06 g, 91% of theory) was obtained as a yellowish solid. Synthesis step 6: (rac)-methyl-4-(3-{[3,5-bis(trifluoromethyl)benzamido](cyclopropyl)methyl}pyrazin-2-yl)benzoate (I.1-284) 25 Methyl-4-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoate (250 mg, 0.78 mmol, 1.0 eq) was dissolved in absolute dichloromethane under argon in a heated round-bottom flask and, after stirring for 5 minutes at room temperature, reacted with triethylamine (0.33 mL, 2.34 mmol, 3.0 eq) and 3,5-bis(trifluoromethyl)benzoic acid. BCS241005-Ausland STR 81 (202 mg, 0.78 mmol, 1.0 eq) and 50% propanephosphonic anhydride were added to THF (0.84 mL, 1.40 mmol, 1.8 eq). The resulting reaction mixture was stirred at room temperature for 14 h, then dichloromethane was added and washed with dilute HCl (1 M). The organic phase was dried over sodium sulfate, filtered, and concentrated under reduced pressure. Methyl 4-(3-{[3,5-bis(trifluoromethyl)benzamido](cyclopropyl)-methyl}pyrazin-2-yl)benzoate (I.1-284) was obtained as a colorless solid (350 mg, 83% of theory) by five column chromatographic purifications of the crude product (gradient heptane/ethyl acetate).1H NMR (400 MHz, CDCl3): δ (ppm) = 8.65 (d, J = 2.2 Hz, 1H), 8.60 (d, J = 2.2 Hz, 1H), 8.29 (s, 2H), 8.23 (d, J = 8.3 Hz, 2H), 8.03 (s, 1H), 7.84-7.81 (m, 2H), 7.43 (br d, J = 7.9 Hz, 1H), 5.13 (t, J = 8.4 Hz, 1H), 3.98 (s, 3H), 1.22 - 1.13 (m, 1H), 10 0.56-0.49 (m, 1H), 0.40-0.31 (m, 2H), -0.03 - -0.11 (m, 1H). No. I.2-48: (rac)-Methyl-3-{3-[1-(3-chloro-5-iodobenzamido)propyl]pyrazin-2-yl}benzoate Synthesis step 1: 1-(2-bromopyrazin-3-yl)propan-1-ol 15 A solution of N-isopropylpropan-2-amine (87.8 g, 868 mmol, 123 mL, 2.30 eq) in absolute tetrahydrofuran (420 mL) was cooled to -78 °C under a nitrogen atmosphere and treated dropwise with a solution of n-butyllithium in absolute tetrahydrofuran (2.5 M, 332 mL, 2.20 eq). The resulting reaction mixture was stirred for 30 minutes at -30 °C, cooled again to -78 °C, and treated dropwise with a solution of 2-bromopyrazine (60.0 g, 377 mmol, 1.00 eq) in absolute tetrahydrofuran (180 mL). The resulting reaction mixture was then stirred for 30 minutes at a temperature of -78 °C, followed by the dropwise addition of a solution of propanal (48.2 g, 830 mmol, 60.4 mL, 2.20 eq) in abs. tetrahydrofuran (60.0 mL), and the reaction mixture was stirred for another 60 minutes. After complete conversion (thin-layer chromatography and LC-MS control), the reaction mixture was treated with aqueous NH₃.4The mixture was treated with Cl solution (500 mL) and extracted several times with EtOAc (200 mL x 3). The combined organic phases were washed with saturated NaCl solution (200 mL), then purified over Na2SO4The residue was dried, filtered, and concentrated under reduced pressure. The remaining residue was purified by column chromatography (SiO₂).2Petroleum ether/ethyl acetate (5:1 to 20:1) and 1-(2-30-bromopyrazin-3-yl)propan-1-ol (30.0 g, 32.9% of theory) were obtained as a yellowish oil. Petroleum ether/ethyl acetate (5:1 to 20:1) and 1-(2-30-bromopyrazin-3-yl)propan-1-ol (30.0 g, 32.9% of theory) were obtained. BCS241005-Abroad STR 82 Synthesis Step 2: 1-(2-Bromopyrazin-3-yl)propan-1-one ``` 1-(2-Bromopyrazin-3-yl)propan-1-ol (26.0 g, 120 mmol, 1.00 eq) was dissolved in absolute dichloromethane (182 mL) 5, mixed with pyridinium chlorochromate (PCC, 52.0 g, 240 mmol, 2.00 eq), and stirred for 12 h at room temperature. After complete conversion (reaction checked by thin-layer chromatography), the reaction mixture was filtered and concentrated under reduced pressure. The remaining residue (SiO₂) was purified by column chromatography.2, Petroleum ether/ethyl acetate = 5/1 to 20/1) yielded 1-(2-bromopyrazin-3-yl)propan-1-one (21.0 g, 81.5% of the theory) in the form of a yellow solid.1H-NMR (400 MHz, CDCl3): δ (ppm) = 8.56 - 8.60 (m, 1 H) 8.49 (d, J=2.38 Hz, 1 H) 3.13 (q, J=7.17 Hz, 2 H) 1.25 (t, J=7.25 Hz, 3 H). Synthesis step 3: tert-Butyl-[1-(3-bromopyrazin-2-yl)propyl]carbamate 15 In the next step, ammonium acetate (96.8 g, 1.26 mol, 15.0 eq) was added to a solution of 1-(2-bromopyrazin-3-yl)propan-1-one (18.0 g, 83.7 mmol, 1.00 eq) in abs. MeOH (126 mL) at room temperature. The resulting reaction mixture was stirred for 2 h at a temperature of 60 °C, then treated with NaBH₄.3CN (52.6 g, 837 mmol, 10.0 eq) was added and stirred for 10 h at a temperature of 60°C. After complete conversion (reaction control by LCMS), the reaction mixture was concentrated under reduced pressure, and the resulting 1-(3-bromopyrazin-2-yl)propan-1-amine (18.0 g, 83.3 mmol, 1.00 eq) obtained as a yellow solid was used without further purification in the next reaction step in a mixture of tetrahydrofuran (36.0 mL) and H2O (54.0 mL) dissolved. Then Na2CO3 (26.5 g, 250 mmol, 3.00 eq) and Boc2O₂ (27.3 g, 125 mmol, 28.7 mL, 1.50 eq) was added and the resulting reaction mixture was stirred for 12 h at room temperature (25°C). After complete conversion (reaction checked by LC-MS), the reaction mixture was thoroughly extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), and rinsed over Na₂O.2SO4Dried, filtered, and concentrated under reduced pressure. Purification of the remaining residue (SiO₂) by column chromatography.2From a mixture of petroleum ether and ethyl acetate (5:1 to 20:1), tert-butyl-[1-(3-bromopyrazin-2-yl)propyl]carbamate (13.0 g, 49.3% of theory) was obtained as a colorless solid (30 g). (Petroleum ether/ethyl acetate = 5:1 to 20:1) BCS241005-Ausland STR 83 Synthesis stage 4: Methyl 3-(3-{1-[(tert-butoxycarbonyl)amino]propyl}pyrazin-2-yl)benzoate tert-Butyl-[1-(3-bromopyrazin-2-yl)propyl]carbamate (11.5 g, 36.4 mmol, 1.00 eq), methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzoate (14.3 g, 54.6 mmol, 1.50 eq), K2CO3(10.0 g, 72.7 mmol, 5 2.00 eq) and Pd(dppf)Cl2(2.66 g, 3.64 mmol, 0.100 eq) were dissolved under argon in abs. dioxane (57.5 mL) and H2O₂ (11.5 mL) was dissolved, and the resulting reaction mixture was stirred under argon at 100 °C for 12 h. The reaction progress was monitored by LC-MS, and after complete conversion of the starting materials, the reaction mixture was cooled to room temperature, extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), and rinsed over Na₂O₂.2SO410. Dried, filtered, and concentrated under reduced pressure. Purification of the remaining residue (SiO₂) by column chromatography.2From a mixture of petroleum ether and ethyl acetate (5:1 to 20:1), methyl 3-(3-{1-[(tert-butoxycarbonyl)amino]propyl}pyrazin-2-yl)benzoate (12.0 g, 89% of theory) was obtained as a yellowish solid. 15 Synthesis Step 5: Methyl 3-[3-(1-aminopropyl)pyrazin-2-yl]benzoate Methyl 3-(3-{1-[(tert-butoxycarbonyl)amino]propyl}pyrazin-2-yl)benzoate (4.00 g, 10.7 mmol, 1.00 eq) was then dissolved in HCl/dioxane (4.00 mL) and dichloromethane (20.0 mL) and stirred for 12 h at room temperature. The reaction mixture was then concentrated under reduced pressure, and the remaining residue was recrystallized from ethyl acetate (50.0 mL). In this way, methyl 3-[3-(1-aminopropyl)pyrazin-2-yl]benzoate (3.04 g, 92% of theory) was obtained as a yellowish solid.1H-NMR (400 MHz, CDCl3): δ (ppm) = 8.83 (q, J=2.36 Hz, 2 H) 8.74 (br s, 2 H) 8.17 - 8.21 (m, 1 H) 8.13 (dt, J=7.89, 1.25 Hz, 1 H) 7.98 - 8.03 (m, 1 H) 7.71 - 7.78 (m, 1 H) 4.36 (t, J=6.85 Hz, 1 H) 3.87 - 3.93 (m, 3 H) 1.75 - 1.91 (m, 2 H) 0.63 (t, J=7.46 Hz, 3 H). 25 BCS241005-Ausland STR 84 Synthesis step 6: No. I.2-48: (rac)-methyl-3-{3-[1-(3-chloro-5-iodobenzamido)propyl]pyrazin-2-yl}benzoate Methyl 3-[3-(1-aminopropyl)pyrazin-2-yl]benzoate (300 mg, 0.97 mmol, 1.0 eq) was dissolved under argon in a heated round-bottom flask in absolute acetonitrile (10 mL) and, after stirring for 5 minutes at room temperature, was treated with triethylamine (0.41 mL, 2.92 mmol, 3.0 eq), 3-chloro-5-iodobenzoic acid (275 mg, 0.97 mmol, 1.0 eq), and 50% propanephosphonic anhydride in THF (1.04 mL, 1.75 mmol, 1.8 eq). The resulting reaction mixture was stirred for 6 h at room temperature, then treated with dichloromethane and washed with dilute HCl (1 M). The organic phase was dried over 10 mg sodium sulfate, filtered, and concentrated under reduced pressure. Column chromatographic purification of the crude product (gradient heptane/ethyl acetate) yielded methyl-3-{3-[1-(3-chloro-5-iodobenzamido)propyl]pyrazin-2-yl}benzoate (I.2-48) as a colorless solid (304 mg, 57% of theory).1H-NMR (peak picking: 400 MHz, CDCl3): δ= 8.6366 (2.6); 8.6306 (3.3); 8.5933 (3.1); 8.5874 (2.4); 8.3196 (1.6); 8.3157 (2.6); 8.3117 (1.5); 8.1982 (1.4); 8.1787 15 (1.5); 8.0119 (1.9); 8.0084 (3.1); 8.0049 (1.8); 7.9370 (1.2); 7.9177 (1.4); 7.8423 (1.8); 7.8382 (2.8); 7.8341 (1.7); 7.7511 (2.0); 7.7470 (2.8); 7.7429 (1.6); 7.6635 (1.3); 7.6441 (2.4); 7.6249 (1.2); 7.2630 (9.0); 7.1555 (0.9); 7.1341 (0.9); 5.5674 (0.9); 5.5506 (0.9); 5.5315 (0.5); 5.3018 (7.6); 3.9517 (16.0); 2.0476 (0.8); 1.8385 (0.8); 1.8225 (0.8); 1.8045 (0.7); 1.7874 (0.8); 1.7691 (1.1); 1.7510 (0.9); 1.7344 (0.6); 1.5958 (2.0); 1.2607 (1.1); 0.8817 (0.8); 0.7828 (3.0); 0.7643 (6.4); 0.7458 (2.9); -0.0002 (11.2); - 20 0.0083 (0.7) No. I.2-98: Methyl 3-(3-{[3-bromo-5-(trifluoromethoxy)benzamido](cyclopropyl)methyl}pyrazin-2-yl)benzoate 25 Synthesis step 1: (3-bromopyrazin-2-yl)(cyclopropyl)methanol A solution of N-isopropylpropan-2-amine (58.6 g, 579 mmol, 82 mL, 2.30 eq) in absolute tetrahydrofuran (280 mL) was cooled to -78 °C under an argon atmosphere and diluted dropwise with 30 mg of a solution of n-butyllithium in absolute tetrahydrofuran (2.5 M, 221 mL, 2.20 eq). TheThe resulting reaction mixture (BCS241005-Ausland STR 85) was stirred for 30 minutes at a temperature of -30 °C, cooled again to -78 °C, and a solution of 2-bromopyrazine (40.0 g, 252 mmol, 1.00 eq) in abs. tetrahydrofuran (120 mL) was added dropwise. The resulting reaction mixture was then stirred for 30 minutes at a temperature of -78 °C, followed by the dropwise addition of a solution of cyclopropanecarbaldehyde (35.3 g, 503 mmol, 37.6 mL, 2.20 eq) in abs. tetrahydrofuran (40.0 mL), and the reaction mixture was stirred for 60 minutes at a temperature of -78 °C. After complete conversion (thin-layer chromatography and LC-MS control), the reaction mixture was treated with aqueous NH₃.4The mixture was treated with Cl solution (500 mL) and extracted several times with EtOAc (200 mL x 3). The combined organic phases were washed with saturated NaCl solution (200 mL x 10 mL), then rinsed over Na2SO4The residue was dried, filtered, and concentrated under reduced pressure. The remaining residue was purified by column chromatography (SiO₂).2Petroleum ether/ethyl acetate (5:1 to 20:1) and (3-bromopyrazin-2-yl)(cyclopropyl)methanol (45.0 g, 78% of theory) were obtained in the form of a yellowish oil. 15 Synthesis step 2: 3-bromopyrazin-2-yl)(cyclopropyl)methanone (3-Bromopyrazin-2-yl)(cyclopropyl)methanol (45.0 g, 196 mmol, 1.00 eq) was dissolved in absolute dichloromethane (315 mL), mixed with pyridinium chlorochromate (PCC, 84.7 g, 393 mmol, 2.00 eq), and stirred for 12 h at room temperature. After complete conversion (reaction checked by 20 thin-layer chromatography), the reaction mixture was filtered and concentrated under reduced pressure. The remaining residue (SiO₂) was purified by column chromatography.2, Petroleum ether/ethyl acetate = 5/1 to 20/1) yielded 3-bromopyrazin-2-yl)(cyclopropyl)methanone (24.0 g, 54% of theory) in the form of a yellow solid.1H-NMR (400 MHz, CDCl3): δ (ppm) = 8.51-8.55 (m, 1H) 8.38-8.42 (m, 1H) 2.76-2.85 (m, 1H), 1.29 (m, 2H), 1.06-1.14 (m, 2H). 25 Synthesis step 3: tert-Butyl-[(3-bromopyrazin-2-yl)(cyclopropyl)methyl]carbamate In the next step, ammonium acetate (91.7 g, 1.19 mol, 15.0 eq) was added to a solution of 3-bromopyrazin-2-yl)(cyclopropyl)methanone (18.0 g, 79.3 mmol, 1.00 eq) in abs. MeOH (126 mL) at room temperature (30°C). The resulting reaction mixture was stirred for 2 h at 60°C, then treated with NaBH₄.3CN (49.8 g, 793 mmol, 10.0 eq) added and incubated for 10 h at a temperature BCS241005-Abroad STR 86 was stirred further at 60°C. After complete conversion (reaction control via LCMS), the reaction mixture was concentrated under reduced pressure, and the 1-(3-bromopyrazin-2-yl)-1-cyclopropylmethanamine obtained as a yellow solid (18.0 g, 78.9 mmol, 1.00 eq) was used in the next reaction step without further purification in a mixture of tetrahydrofuran (36.0 mL) 5 and H2O (54.0 mL) dissolved. Then Na2CO3 (25.1 g, 237 mmol, 3.00 eq) and Boc2O₂ (25.8 g, 118 mmol, 1.50 eq) was added and the resulting reaction mixture was stirred for 12 h at room temperature. After complete conversion (reaction control by LC-MS), the reaction mixture was thoroughly extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), and rinsed over Na₂.2SO4dried, filtered, and concentrated under reduced pressure. Purification of the remaining residue (SiO₂) by column chromatography.2From a mixture of petroleum ether and ethyl acetate (5/1 to 20/1), tert-butyl-[(3-bromopyrazin-2-yl)(cyclopropyl)methyl]carbamate (11.0 g, 43% of theory) was obtained as a colorless solid. Synthesis step 4: Methyl-3-(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)methyl}pyrazin-2-yl)benzoate 15 tert-Butyl-[(3-bromopyrazin-2-yl)(cyclopropyl)methyl]carbamate (10.0 g, 30.5 mmol, 1.00 eq), methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzoate (11.9 g, 45.7 mmol, 1.50 eq), K2CO3(8.42 g, 60.9 mmol, 2.00 eq) and Pd(dppf)Cl2(2.23 g, 3.05 mmol, 0.100 eq) were dissolved under argon in abs. dioxane (50.0 mL) and H2O₂ (10.0 mL) was dissolved, and the resulting reaction mixture was stirred under argon at a temperature of 20–100 °C for 12 h. The reaction progress was monitored by LC-MS, and after complete conversion of the starting materials, the reaction mixture was cooled to room temperature, extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), and rinsed over Na₂O₂.2SO4Dried, filtered, and concentrated under reduced pressure. Purification of the remaining residue (SiO₂) by column chromatography.2From a reaction of petroleum ether/ethyl acetate (5:1 to 20:1), methyl 3-25(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)methyl}pyrazin-2-yl)benzoate (10.6 g, 90% of theory) was obtained as a yellowish solid. Synthesis step 5: Methyl 3-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoate BCS241005-Abroad STR 87 ```Methyl 3-(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)-methyl}pyrazin-2-yl)benzoate (4.00 g, 10.4 mmol, 1.00 eq) was dissolved in HCl/dioxane (4.00 mL) and dichloromethane (20.0 mL) and stirred at room temperature for 12 h. The reaction mixture was then concentrated under reduced pressure, and the remaining residue was recrystallized from ethyl acetate (50.0 mL). In this way, methyl 4-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoate (2.91 g, 87% of theory) was obtained as a colorless solid. Synthesis step 6: (rac)-methyl-3-(3-{[3-bromo-5-10(trifluoromethoxy)benzamido](cyclopropyl)methyl}pyrazin-2-yl)benzoate (I.2-98) Methyl 3-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoate (300 mg, 0.94 mmol, 1.0 eq) was dissolved in absolute dichloromethane under argon in a heated round-bottom flask and, after stirring for 10 minutes at room temperature, treated with triethylamine (0.39 mL, 2.81 mmol, 3.0 eq), 3-bromo-5-15(trifluoromethoxy)benzoic acid (262 mg, 0.92 mmol, 1.0 eq), and 50% propanephosphonic anhydride in THF (1.01 mL, 1.69 mmol, 1.8 eq). The resulting reaction mixture was stirred for 12 h at room temperature, then treated with dichloromethane and washed with dilute HCl (1 M). The organic phase was subsequently dried over magnesium sulfate, filtered, and concentrated under reduced pressure. Column chromatographic purification of the crude product (gradient 20 heptane/ethyl acetate) yielded methyl 3-(3-{[3-bromo-5-(trifluoromethoxy)benzamido](cyclopropyl)methyl}pyrazin-2-yl)benzoate (I.2-98) as a colorless solid (406 mg, 74% of theory).1H NMR (400 MHz, CDCl3): δ (ppm) = 8.64-8.63 (d, , 1H), 8.59-6.58 (d, 1H), 8.38 (s, 1H), 8.19-8.17 (d, 1H), 7.98-7.97 (d, 1H), 7.87 (s, 1H), 7.65-7.60 (m, , 2H), 7.53 (s, 1H), 5.13-5.09 (t, 1H), 3.95 (s, 3H), 1.25 - 1.19 (m, 1H), 0.55-0.48 (m, 1H), 0.42-0.30 (m, 25 2H), 0.06 - 0.02 (m, 1H). In analogy to the manufacturing examples mentioned above and quoted at the appropriate point BCS241005-Abroad STR 88 and taking into account the general information on the preparation of substituted arylpyrazines, the following compounds are obtained. In Tables I.1 to I.3, if a structural element is defined by a structural formula containing a dashed line, this dashed line indicates that the group in question is bonded to the rest of the molecule at that position. The corresponding stereochemical configuration at the stereocenter C-1 (see formula I.1 below) is indicated by the designations “Rac” for a racemic mixture of both enantiomers, “Ent-1” for the enantiomer with the lower retention time in chiral HPLC analysis or chiral preparative SFC, and “Ent-2” for the enantiomer with the higher retention time in chiral HPLC analysis or chiral preparative SFC. In the following 10 tables, the designations 1-methyleth-1-yl, 1-methylethyl, and propyl-2-yl represent an isopropyl group, and the different designations for the same group are common in the field. Table I.1: Preferred compounds of formula (I.1) are compounds I.1-1 to I.1-559, where Q has the meanings given in the respective row of Table I.1. Compounds I.1-1 to I.1-559 of Table I.1 are thus distinguished by the meaning of the respective entries for the substituents R.1, R7, R17, R18and R19defined in Table I.1, where R2, R5and R6for hydrogen. Table I.1: 20 BCS241005-Abroad STR 89 BCS241005-Abroad STR 90 BCS241005-Abroad STR 91 BCS241005-Abroad STR 92 BCS241005-Abroad STR 93 BCS241005-Abroad STR 94 BCS241005-Abroad STR 95 BCS241005-Abroad STR 96 BCS241005-Abroad STR 97 BCS241005-Abroad STR 98 BCS241005-Abroad STR 99 BCS241005-Abroad STR 100 BCS241005-Abroad STR 101 BCS241005-Abroad STR 102 BCS241005-Abroad STR 103 ```Table I.2: Preferred compounds of formula (I.2) are compounds I.2-1 to I.2-225, where Q has the meanings given in the respective row of Table I.2. Compounds I.2-1 to I.2-225 of Table I.2 are thus distinguished by the meaning of the respective entries for the substituents R.1, 5 R7, R18, R19and R20defined in Table I.2, where R2, R5and R6Table I.2: Represents hydrogen. BCS241005-Abroad STR 104 BCS241005-Abroad STR 105 BCS241005-Abroad STR 106 BCS241005-Abroad STR 107 BCS241005-Abroad STR 108 BCS241005-Abroad STR 109 ```Table I.3: Preferred compounds of formula (I.3) are compounds I.3-1 to I.3-18, where Q has the meanings given in the respective row of Table I.3. Compounds I.3-1 to I.3-18 of Table I.3 are thus distinguished by the meaning of the respective entries for the substituents R.1, 5 R7, R17, R18and R20defined in Table 3, where R2, R5and R6stand for hydrogen. ... BCS241005-Abroad STR 110 Table I.3: ``` Spectroscopic data of selected examples from the tables listed above: 5 The spectroscopic data of the table examples listed below were determined either using classical methods1H-NMR interpretation or evaluated using the NMR peak list method. a) classical NMR interpretation 10 BCS241005-Abroad STR 111 I.1-86: 1H-NMR (400 MHz, d6-DMSO): δ= 8.73 (d,1H); 8.66 (d,1H); 8.64 (d,1H); 8.06 (d,2H); 7.79 (d,2H); 7.32 (dd,1H); 7.29 (d,1H); 7.12 (d,1H); 5.26 (m,1H); 4.35 (t,2H); 3.21 (t,2H); 1.41 (d,3H) I.1-91: 1H-NMR (400 MHz, CDCl3): δ= 8.62 (d,1H); 8.58 (d,1H); 8.21 (d,2H); 7.75 (d,2H); 7.35 5 (dd,1H); 7.30 (d,1H); 7.18 (d,1H); 6.84 (d,1H); 6.02 (s,2H); 5.63 (m,1H); 3.97 (s,3H); 1.39 (d,3H) I.1-92: 1H-NMR (400 MHz, d6-DMSO): δ= 8.68 (d,1H); 8.65 (d,1H); 8.63 (d,1H); 8.06 (d,2H); 7.79 (d,2H); 7.74 (d,1H); 7.52 (dd,1H); 6.89 (d,1H); 5.83 (s,2H); 5.26 (m,1H); 1.42 (d,3H) 10 I.1-93: 1H-NMR (400 MHz, d6-DMSO): δ= 8.67 (d,1H); 8.66 (d,1H); 8.63 (d,1H); 8.07 (dd,2H); 7.80 (dd,2H); 7.42 (dd,1H); 7.37 (d,1H); 6.95 (d,1H); 6.07 (s,2H); 5.27 (m,1H); 1.42 (d,3H) I.1-102: 1H-NMR (600 MHz, d6-DMSO, ppm) 9.17 (bd, 1H), 8.98 (s, 2H), 8.70 (d, 1H), 8.67 (d, 1H), 8.07 (d, 2H), 7.80 (d, 2H), 5.32 (m, 1H), 3.90 (s, 3H), 2.65 (s, 3H), 1.47 (d, 3H). 15 I.1-103: 1H-NMR (600 MHz, d6-DMSO, ppm): δ = 8.65 (m, 1H), 8.67 (d, 1H), 8.64 (d, 1H), 8.07 (d, 2H), 7.81 (d, 2H), 7.56 (d, 2H), 7.33 (m, 1H), 5.28 (m, 1H), 3.90 (s, 3H), 2.26 (s, 3H), 1.44 (d, 3H). I.1-104: 1H-NMR (600 MHz, d6-DMSO, ppm): δ = 8.93 (bd, 1H), 8.75 (d, 1H), 8.71 (d, 1H), 8.46 (d, 20 1H), 8.11 (d, 2H), 7.79 (d, 2H), 7.47 (d, 1H), 7.16 (m, 1H), 5.34 (m, 1H), 3.91 (s, 3H), 1.42 (d, 3H). I.1-105: 1H-NMR (600 MHz, d6-DMSO, ppm): δ = 8.96 (s, 1H), 8.91 (d, 1H), 8.74 (s, 1H), 8.70 (s, 1H), 8.61 (s, 1H), 8.10 (d, 2H), 7.79 (d, 2H), 5.38 (m, 1H), 3.91 (s, 3H), 2.58 (s, 3H), 1.43 (d, 3H). 25 I.1-106: 1H-NMR (400 MHz, CDCl3): δ= 8.68 (d,1H); 8.66 (d,1H); 8.59 (d,1H); 8.44 (d,1H); 8.29 (dd,1H); 8.23 (d,2H); 7.73 (d,2H); 7.53 (d,1H); 5.69 (m,1H); 3.98 (s,3H); 3.48 (s,3H); 3.45 (s,3H); 1.44 (d,3H) I.1-107: 1H-NMR (400 MHz, CDCl3): δ= 8.67 (d,1H); 8.58 (d,1H); 8.24 (d,2H); 7.77 (d,1H); 7.74 30 (d,2H); 7.61 (dd,1H); 7.58 (d,1H); 7.42 (d,1H); 5.67 (m,1H); 5.09 (s,2H); 3.98 (s,3H); 1.41 (d,3H) I.1-108: 1H-NMR (400 MHz, CDCl3): δ= 8.65 (d,1H); 8.59 (d,1H); 8.23 (d,2H); 7.96 (dd,1H); 7.74 (d,2H); 7.66 (dd,1H); 7.59 (ddd,1H); 7.42 (d,1H); 5.67 (m,1H); 5.55 (d,1H); 5.06 (d,1H); 3.98 (s,3H); 1.41 (d,3H) 35 BCS241005-Abroad STR 112 I.1-109: 1H-NMR (400 MHz, d6-DMSO): δ= 9.06 (d,1H); 8.68 (d,1H); 8.66 (d,1H); 8.08 (d,2H); 7.80 (d,2H); 7.79 (d,1H); 7.53 (dd,1H); 7.43 (d,1H); 5.28 (m,1H); 4.79 (m,2H); 3.90 (s,3H); 3.88 (m,2H); 1.45 (d,3H) 5 I.1-110: 1H-NMR (400 MHz, CDCl3): δ= 8.65 (d,1H); 8.60 (d,1H); 8.22 (dd,2H); 8.13 (dd,1H); 8.10 (d,1H); 7.73 (d,2H); 7.39 (d,1H); 7.19 (d,1H); 5.66 (m,1H); 5.12 (s,2H); 3.97 (s,3H); 1.40 (d,3H) I.1-111: 1H-NMR (400 MHz, d6-DMSO): δ= 9.14 (d,1H); 8.67 (d,1H); 8.65 (d,1H); 8.34 (d,1H); 8.08 (d,2H); 7.96 (dd,1H); 7.82 (d,2H); 7.11 (d,1H); 5.29 (m,1H); 4.81 (m,2H); 3.90 (s,3H); 3.89 (m,2H); 10 1.45 (d,3H) I.1-112: 1H-NMR (400 MHz, d6-DMSO): δ= 9.03 (d,1H); 8.68 (d,1H); 8.66 (d,1H); 8.07 (d,2H); 7.79 (d,2H); 7.69 (d,1H); 7.37 (d,1H); 7.35 (s,1H); 5.28 (m,1H); 3.67 (t,2H); 3.58 (t,2H); 1.44 (d,3H) 15 I.1-113: 1H-NMR (400 MHz, d6-DMSO): δ= 8.97 (d,1H); 8.67 (d,1H); 8.64 (d,1H); 8.17 (d,1H); 8.06 (d,2H); 7.97 (dd,1H); 7.80 (d,2H); 7.01 (d,1H); 5.28 (m,1H); 3.67 (t,2H); 3.59 (t,2H); 1.43 (d,3H) I.1-114: 1H-NMR (400 MHz, CDCl3): δ= 8.68 (d,1H); 8.61 (d,1H); 8.37 (d,1H); 8.36 (dd,1H); 8.23 (d,2H); 8.08 (d,1H); 7.72 (d,2H); 7.58 (d,1H); 5.68 (m,1H); 4.76 (s,2H); 3.98 (s,3H); 1.43 (d,3H) 20 I.1-130: 1H-NMR (400 MHz, CDCl3): δ= 8.67 (d,1H); 8.60 (d,1H); 8.36 (d,1H); 8.27 (dd,1H); 8.23 (d,2H); 8.10 (d,1H); 7.72 (d,2H); 7.51 (d,1H); 5.68 (m,1H); 4.11 (s,4H); 3.98 (s,3H); 1.42 (d,3H) I.1-141: 1H-NMR (400 MHz, CDCl3): δ= 8.71 (d,1H); 8.60 (d,1H); 8.48 (d,1H); 8.32 (dd,1H); 8.25 25 (d,2H); 8.08 (d,1H); 8.06 (d,1H); 7.75 (d,2H); 5.66 (m,1H); 4.12 (s,4H); 1.48 (d,3H) I.1-162: 1H-NMR (400 MHz, d6-DMSO^, ppm) 9.68 (d, 2H), 8.06 (d, 2H), 7.82 (d, 2H), 7.71 (s, 1H), 7.68 (s, 1H), 7.45 (s, 1H), 5.45 (s, 1H), 5.35 (m, 1H), 3.89 (s, 1H), 1.84-1.82 (m, 2H), 1.74-1.71 (m, 2H), 1.43 (d, 3H). 30 I.1-172: 1H-NMR (400 MHz, CDCl3): δ= 8.73 (s,1H); 8.67 (d,1H); 8.62 (d,1H); 8.48 (s,2H); 8.31 (t,1H); 8.25 (d,2H); 8.19 (d,1H); 7.76 (d,2H); 7.51 (d,1H); 5.70 (m,1H); 3.98 (s,3H); 3.17 (s,3H); 1.46 (d,3H) I.1-173: 1H-NMR (400 MHz, d6-DMSO): δ= 9.02 (d,1H); 8.68 (d,1H); 8.66 (d,1H); 8.39 (d,1H); 8.08 35 (d,2H); 8.07 (d,1H); 7.82 (d,2H); 7.81 (dd,1H); 5.36 (m,1H); 2.83 (s,3H); 1.47 (d,3H) BCS241005-Abroad STR 113 I.1-184: 1H-NMR (400 MHz, d6-DMSO): δ= 9.12 (d,1H); 8.68 (d,1H); 8.66 (d,1H); 8.50 (m,1H); 8.18- 7.9 (m,6H); 7.82 (d,2H); 7.51 (m,1H); 5.38 (m,1H); 1.49 (d,3H) I.1-186: 1H-NMR (400 MHz, d6-DMSO): δ= 9.48 (d,1H); 8.72 (d,1H); 8.70 (d,1H); 8.68 (d,1H); 8.54 5 (t,1H); 8.47 (t,1H); 8.26 (t,1H); 8.07 (d,2H); 7.87 (d,1H); 7.82 (d,2H); 6.64 (dd,1H); 5.38 (m,1H); 3.32 (s,3H); 1.51 (d,3H) I.1-229: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.72 (bd, 1H), 8.67 (s, 1H), 8.64 (s, 1H), 8.08 (d, 2H), 8.05 (s, 1H), 7.80 (d, 2H), 7.50 (s, 1H), 5.24 (m, 1H), 3.91 (s, 3H), 1.42 (d, 3H). 10 I.1-230: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.74 (bd, 1H), 8.70 (s, 1H), 8.68 (s, 1H), 8.10 (d, 2H), 7.78 (d, 2H), 7.30 (s, 1H), 5.23 (m, 1H), 3.91 (s, 3H), 1.43 (d, 3H). I.1-232: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.72 (bd, 1H), 8.69 (s, 1H), 8.68 (s, 1H), 8.08 (d, 15 2H), 7.73 (d, 2H), 7.30 (s, 1H), 5.23 (m, 1H), 1.41 (d, 3H), 1.28 (t, 3H). I.1-239: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.84 (bd, 1H), 8.72 (d, 1H), 8.70 (d, 1H), 8.11 (d, 2H), 7.79 (d, 2H), 5.30 (m, 1H), 3.91 (s, 3H), 3.74 (s, 3H), 3.31 (s, 3H), 1.42 (d, 3H). 20 I.1-241: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.77-8.69 (m, 3H), 8.10 (d, 1H), 7.78 (d, 2H), 7.59 (s, 1H), 5.29 (m, 1H), 3.90 (s, 3H), 2.43 (s, 3H), 1.43 (d, 3H). I.1-250: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.77 (d, 1H), 8.74 (d, 1H), 8.38 (d, 1H), 8.12 (d, 2H), 7.95 (d, 2H), 5.33 (m, 1H), 3.95 (s, 3H), 3.91 (s, 3H), 1.39 (d, 3H). 25 I.2-2: 1H-NMR (400 MHz, d6-DMSO, ppm): δ = 8.96 (bd, 1H), 8.15-8.13 (m, 2H), 8.11 (m, 1H), 8.03 (m, 1H), 7.98 (m, 1H), 7.73 (m, 1H), 7.67-7.63 (m, 2H), 7.48 (m, 1H), 7.42 (m, 1H), 5.31 (m, 1H), 1.77- 1.74 (m, 2H), 1.56-1.53 (m, 2H), 1.48 (d, 3H). 30 I.2-156: 1H NMR (400 MHz, CDCl3): δ (ppm) = 8.64-8.63 (d, , 1H), 8.59-6.58 (d, 1H), 8.37 (s, 1H), 8.19- 8.17 (d, 1H), 7.99-7.97 (d, 1H), 7.87 (s, 1H), 7.65-7.60 (m, 2H), 7.53 (s, 1H), 5.13-5.09 (t, 1H), 3.95 (s, 3H), 1.25 - 1.19 (m, 1H), 0.55-0.48 (m, 1H), 0.42-0.30 (m, 2H), 0.06 - 0.02 (m, 1H). I.2-157: 1H NMR (400 MHz, CDCl3): δ (ppm) = 8.64-8.63 (d, , 1H), 8.59-6.58 (d, 1H), 8.38 (s, 1H), 8.20- 35 8.18 (d, 1H), 7.98-7.96 (d, 1H), 7.88 (s, 1H), 7.65-7.60 (m, , 2H), 7.52 (s, 1H), 5.13-5.09 (t, 1H), 3.95 (s, 3H), 1.25 - 1.19 (m, 1H), 0.55-0.48 (m, 1H), 0.42-0.30 (m, 2H), 0.06 - 0.02 (m, 1H). BCS241005-Abroad STR 114 b) NMR Peak List Procedure The1H-NMR data of selected examples can also be presented in the form of1H-NMR peak lists are recorded. For each signal peak, the ^-value in ppm is listed first, followed by the signal intensity in parentheses. The ^^-value-signal intensity pairs of different signal peaks are listed separated by semicolons. The peak list of an example therefore has the form: ^1(Intensity1 ); ^2(Intensity2);……..; ^i(Intensityi );……; ^n(Intensityn) 10 The intensity of sharp signals correlates with the height of the signals in a printed example of an NMR spectrum in cm and shows the true ratios of the signal intensities. For broad signals, multiple peaks or the center of the signal and its relative intensity compared to the most intense signal in the spectrum can be shown. To calibrate the chemical shift of 1H-NMR spectra, we use tetramethylsilane and/or the chemical shift of the solvent, especially in the case of spectra measured in DMSO. Therefore, the tetramethylsilane peak may appear in NMR peak lists, but it does not have to. The lists of1H-NMR peaks are similar to the classical ones.1H-NMR printouts and thus usually contain all the peaks listed in a classical NMR interpretation. Furthermore, they can be interpreted like classical NMR.1H-20 NMR printouts show solvent signals, signals of stereoisomers of the target compounds, which are also part of the invention, and/or peaks of impurities. When indicating compound signals in the delta region of solvents and/or water, our lists of1H-NMR peaks are the usual solvent peaks, for example peaks of DMSO in DMSO-D6and the peak of water, shown, which usually exhibits a high average intensity. 25 The peaks of stereoisomers of the target compounds and/or peaks of impurities usually have a lower average intensity than the peaks of the target compounds (for example, with a purity of >90%). Such stereoisomers and/or impurities may be typical for the respective manufacturing process. Their peaks can thus help to recognize the reproducibility of our manufacturing process by means of “by-product fingerprints.” An expert who calculates the peaks of the target compounds using known methods (MestreC, ACD simulation, but also with empirically evaluated expected values) can isolate the peaks of the target compounds as needed, using additional intensity filters if necessary. This isolation would be similar to the peak picking involved in classical 1H-NMR interpretation. Further details on1¹H NMR peak lists can be found in the 35 Research Disclosure Database, number 564025. Example No.: ¹H NMR peak lists can be found in the 35 Research Disclosure Database, number 564025. BCS241005-Abroad STR 115 I.1-1: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6688 (2.5); 8.6627 (3.1); 8.6111 (2.3); 8.6049 (2.0); 8.2496 (2.9); 8.2455 (4.8); 8.2406 (1.1); 8.2289 (1.0); 8.2240 (3.4); 8.0194 (1.1); 7.7490 (3.2); 7.7441 (1.0); 7.7324 (0.9); 7.7276 (3.0); 7.2609 (26.9); 5.7125 (0.5); 5.6956 (0.6); 5.6764 (0.6); 3.9778 (16.0); 1.5657 (0.7); 1.4524 (4.6); 1.4356 (4.7); 1.2553 (1.8); 0.0080 (1.1); 0.0022 (1.5); -0.0002 (37.4); -0.0026 (1.7); - 0.0042 (0.7); -0.0084 (1.1) I.1-2: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4468 (2.8); 9.4303 (3.0); 8.6580 (3.9); 8.6519 (14.0); 8.6480 (16.0); 8.6419 (4.8); 8.4821 (9.8); 8.2856 (4.5); 8.0102 (7.5); 7.9897 (8.8); 7.6739 (7.2); 7.6534 (6.6); 5.4230 (1.9); 5.4061 (3.0); 5.3891 (1.9); 3.3313 (5.2); 2.6805 (0.5); 2.6759 (1.2); 2.6712 (1.7); 2.6667 (1.2); 2.5418 (4.9); 2.5369 (0.9); 2.5323 (1.1); 2.5250 (4.9); 2.5203 (6.4); 2.5116 (95.7); 2.5071 (209.6); 2.5024 (292.9); 2.4979 (200.8); 2.4933 (88.0); 2.3341 (1.3); 2.3295 (1.7); 2.3248 (1.2); 2.3203 (0.5); 1.4922 (11.3); 1.4750 (11.3); 0.1458 (0.7); 0.0295 (0.6); 0.0080 (6.5); -0.0002 (230.9); -0.0085 (6.2); -0.1494 (0.7) I.1-3: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6681 (2.4); 8.6621 (2.9); 8.6115 (2.2); 8.6054 (1.8); 8.2494 (2.9); 8.2480 (2.8); 8.2453 (4.8); 8.2404 (1.2); 8.2287 (1.0); 8.2238 (3.3); 8.2197 (0.5); 8.1223 (0.5); 8.0192 (1.1); 7.7488 (3.1); 7.7439 (1.0); 7.7322 (0.9); 7.7273 (2.9); 7.7060 (0.5); 7.2611 (22.8); 5.7126 (0.5); 5.6956 (0.6); 5.6935 (0.6); 5.6765 (0.6); 3.9778 (16.0); 3.9533 (2.6); 1.5782 (1.7); 1.4520 (4.5); 1.4353 (4.5); 0.0079 (0.8); -0.0002 (30.1); -0.0085 (0.9) I.1-4: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6680 (1.8); 8.6619 (2.2); 8.6116 (1.9); 8.6055 (1.6); 8.2492 (2.9); 8.2449 (3.8); 8.2400 (1.1); 8.2282 (1.0); 8.2234 (3.3); 8.2192 (0.6); 8.0181 (1.2); 7.7498 (3.0); 7.7449 (1.0); 7.7332 (0.9); 7.7283 (2.9); 7.2624 (10.8); 5.7123 (0.5); 5.6953 (0.6); 5.6932 (0.6); 5.6761 (0.5); 3.9776 (16.0); 2.9581 (1.2); 2.9574 (1.2); 2.8851 (1.1); 2.8837 (1.1); 2.8043 (5.2); 1.4526 (4.5); 1.4358 (4.5); 1.4327 (1.2); 1.2915 (0.6); 1.2743 (0.6); -0.0002 (13.1) I.1-5: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6583 (2.5); 8.6523 (3.2); 8.6071 (2.6); 8.6011 (2.2); 8.2421 (0.5); 8.2380 (3.2); 8.2332 (1.2); 8.2214 (1.2); 8.2166 (3.5); 8.2125 (0.8); 7.9645 (1.8); 7.9606 (1.3); 7.9375 (1.8); 7.9359 (1.7); 7.7463 (2.0); 7.7419 (4.3); 7.7371 (1.4); 7.7252 (1.1); 7.7205 (3.2); 7.7164 (0.7); 7.3751 (0.6); 7.3559 (0.6); 7.2613 (14.2); 5.6860 (0.7); 5.6689 (0.8); 5.6498 (0.7); 3.9756 (16.0); 1.5699 (6.2); 1.4295 (5.3); 1.4128 (5.3); -0.0002 (15.4); -0.0084 (0.7) I.1-6: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2710 (3.2); 9.2545 (3.3); 8.6929 (7.7); 8.6868 (12.1); 8.6681 (13.8); 8.6620 (9.4); 8.1429 (5.8); 8.1391 (3.9); 8.0867 (5.5); 8.0851 (5.6); 8.0670 (1.7); 8.0627 (10.9); 8.0580 (3.6); 8.0463 (3.9); 8.0414 (16.0); 8.0369 (6.8); 7.7909 (1.9); 7.7868 (12.0); 7.7820 (3.8); 7.7703 (3.4); 7.7655 (10.5); 7.7613 (1.6); 5.3529 (2.1); 5.3359 (3.3); 5.3190 (2.2); 4.0570 (0.6); 4.0392 BCS241005-Foreign STR 116 (1.9); 4.0214 (1.9); 4.0036 (0.6); 3.8920 (1.0); 3.3837 (1.9); 2.6771 (0.5); 2.6726 (0.7); 2.6680 (0.5); 2.5431 (0.6); 2.5264 (2.0); 2.5217 (2.7); 2.5130 (39.7); 2.5084 (88.9); 2.5038 (125.6); 2.4992 (87.6); 2.4946 (39.3); 2.3355 (0.5); 2.3308 (0.7); 2.3262 (0.5); 1.9901 (8.9); 1.9108 (6.8); 1.4941 (12.6); 1.4769 (12.6); 1.3565 (1.7); 1.1934 (2.6); 1.1756 (5.3); 1.1578 (2.6); 0.0080 (2.6); 0.0064 (0.7); 0.0056 (0.7); 0.0047 (0.9); -0.0002 (86.2); -0.0050 (1.0); -0.0058 (0.8); -0.0067 (0.7); -0.0085 (2.4) I.1-7: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6670 (2.6); 8.6610 (3.2); 8.6114 (2.6); 8.6053 (2.1); 8.2449 (5.7); 8.2402 (1.4); 8.2284 (1.0); 8.2235 (3.5); 8.2193 (0.6); 8.0190 (1.4); 7.7482 (3.2); 7.7433 (1.2); 7.7317 (1.0); 7.7269 (3.1); 7.7226 (0.6); 7.4505 (0.5); 7.4311 (0.5); 7.2612 (14.8); 5.7124 (0.6); 5.6954 (0.7); 5.6933 (0.7); 5.6762 (0.6); 3.9777 (16.0); 2.8034 (1.8); 1.5696 (5.5); 1.4510 (5.0); 1.4343 (5.0); 0.0080 (0.5); -0.0002 (20.6); -0.0085 (0.6) I.1-8: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7156 (7.9); 8.7095 (9.5); 8.6357 (7.3); 8.6295 (6.4); 8.3037 (16.0); 8.2872 (2.8); 8.2823 (9.3); 8.2782 (1.6); 8.0231 (3.6); 7.8194 (1.8); 7.8079 (1.9); 7.8038 (9.8); 7.7990 (4.4); 7.7873 (2.8); 7.7825 (8.4); 7.7783 (1.3); 7.2643 (0.8); 7.2610 (47.9); 7.2570 (0.6); 5.7676 (1.5); 5.7488 (1.9); 5.7314 (1.6); 3.7575 (1.1); 1.8594 (1.3); 1.5268 (11.4); 1.5100 (11.5); 1.4324 (1.9); 1.2547 (0.8); 1.2424 (1.8); 1.2228 (0.9); 0.0080 (1.9); 0.0039 (0.6); 0.0030 (1.3); 0.0023 (2.2); -0.0002 (68.7); -0.0027 (3.1); -0.0034 (2.1); -0.0043 (1.2); -0.0051 (0.9); -0.0059 (0.8); -0.0067 (0.7); -0.0084 (2.0) I.1-9: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6914 (0.6); 8.6854 (0.7); 8.6707 (0.5); 8.6300 (0.7); 8.6238 (0.6); 8.2954 (0.7); 8.2744 (0.8); 7.7962 (0.8); 7.7752 (0.8); 7.6670 (0.6); 7.2606 (14.8); 5.3000 (16.0); 4.1322 (0.7); 4.1143 (0.8); 2.0469 (3.3); 1.4960 (1.2); 1.4792 (1.2); 1.3332 (0.8); 1.2841 (1.2); 1.2779 (1.5); 1.2599 (4.4); 1.2550 (4.8); 1.2423 (1.8); 0.8802 (0.7); -0.0002 (17.5); -0.0084 (0.9) I.1-10: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4284 (4.2); 9.4118 (4.4); 8.7014 (8.9); 8.6953 (14.2); 8.6771 (15.1); 8.6710 (10.1); 8.4528 (0.5); 8.4354 (14.8); 8.2820 (6.6); 8.0560 (12.5); 8.0516 (4.2); 8.0395 (4.6); 8.0349 (15.3); 7.7911 (14.4); 7.7866 (4.6); 7.7745 (4.3); 7.7700 (12.5); 5.4131 (0.5); 5.3963 (2.7); 5.3794 (4.2); 5.3624 (2.7); 5.3453 (0.6); 3.5955 (0.9); 2.6747 (0.7); 2.5452 (1.0); 2.5284 (2.1); 2.5237 (3.0); 2.5150 (43.9); 2.5104 (93.8); 2.5059 (129.5); 2.5013 (90.2); 2.4968 (40.5); 2.3376 (0.6); 2.3330 (0.7); 2.3282 (0.5); 1.5215 (16.0); 1.5043 (15.9); 0.0079 (1.9); -0.0002 (62.4); -0.0085 (1.8) I.1-11: 1H-NMR (400.6 MHz, CDCl3): δ= 8.8751 (5.7); 8.7310 (5.5); 8.7250 (6.6); 8.6359 (6.5); 8.6298 (9.4); 8.4925 (5.8); 8.3132 (6.0); 8.2928 (7.0); 8.0085 (2.5); 7.9891 (2.7); 7.8053 (6.2); 7.7850 (6.1); 7.2615 (42.5); 5.7614 (1.6); 5.7438 (2.4); 5.7259 (1.8); 5.7082 (0.6); 5.2999 (16.0); 2.3926 (0.8); 2.3737 (0.5); 2.1429 (0.8); 2.0618 (0.7); 2.0480 (1.6); 1.6158 (0.6); 1.6016 (0.6); 1.5421 (9.7); 1.5253 (10.2); 1.5033 (1.1); 1.3337 (1.7); 1.3148 (1.0); 1.2846 (3.1); 1.2782 (2.7); 1.2753 (3.0); 1.2582 (14.5); 1.2428 BCS241005-Abroad STR 117 (2.0); 0.9413 (0.9); 0.9245 (0.9); 0.8964 (1.4); 0.8816 (3.6); 0.8637 (1.8); 0.8364 (0.5); 0.0707 (6.3); 0.0080 (1.1); -0.0002 (48.8); -0.0085 (2.3) I.1-12: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6466 (2.5); 8.6406 (3.2); 8.5971 (2.9); 8.5910 (2.3); 8.2370 (3.2); 8.2325 (1.2); 8.2203 (1.4); 8.2160 (3.7); 8.0722 (1.8); 8.0053 (1.0); 7.9858 (1.1); 7.7803 (0.9); 7.7578 (4.4); 7.7532 (1.5); 7.7410 (1.4); 7.7367 (3.4); 7.6071 (0.8); 7.5877 (1.4); 7.5684 (0.6); 7.3835 (0.6); 7.3636 (0.6); 7.2612 (13.0); 5.7126 (0.8); 5.6956 (0.9); 5.6763 (0.8); 3.9740 (16.0); 1.5701 (2.0); 1.4330 (5.8); 1.4163 (5.8); 0.0079 (0.6); -0.0002 (14.0); -0.0084 (0.6) I.1-13: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6548 (2.6); 8.6487 (3.4); 8.6031 (3.0); 8.5970 (2.5); 8.2455 (3.4); 8.2407 (1.6); 8.2336 (2.4); 8.2293 (2.5); 8.2245 (4.1); 8.1723 (3.4); 8.1678 (1.3); 8.1557 (1.2); 8.1511 (4.0); 8.0360 (1.9); 7.9864 (1.9); 7.7687 (3.6); 7.7641 (1.4); 7.7521 (1.2); 7.7476 (3.5); 7.7132 (3.7); 7.7086 (1.3); 7.6965 (1.2); 7.6920 (3.5); 7.4179 (0.8); 7.3989 (0.9); 7.2606 (34.7); 5.7345 (0.7); 5.7154 (0.9); 5.6983 (0.8); 3.9759 (16.0); 3.9642 (15.9); 1.5536 (11.0); 1.4584 (5.4); 1.4416 (5.5); 0.0080 (1.1); -0.0002 (37.5); -0.0084 (1.8) I.1-14: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6591 (2.5); 8.6531 (3.1); 8.6041 (2.5); 8.5981 (2.1); 8.2382 (3.0); 8.2334 (1.0); 8.2217 (1.0); 8.2169 (3.4); 8.2126 (0.5); 7.8470 (1.5); 7.7422 (3.3); 7.7373 (1.1); 7.7308 (0.6); 7.7256 (1.6); 7.7209 (3.4); 7.7166 (0.6); 7.7047 (0.6); 7.4860 (0.6); 7.4659 (0.6); 7.2608 (19.5); 5.6906 (0.6); 5.6737 (0.7); 5.6544 (0.6); 3.9758 (16.0); 1.5641 (1.2); 1.4281 (5.1); 1.4114 (5.1); 0.8820 (0.6); 0.0080 (0.8); -0.0002 (28.6); -0.0085 (0.8) I.1-15: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6636 (2.6); 8.6576 (3.2); 8.6077 (2.5); 8.6016 (2.1); 8.2385 (3.0); 8.2338 (1.0); 8.2220 (1.0); 8.2172 (3.4); 8.2130 (0.6); 8.1187 (1.6); 8.1150 (1.0); 7.9858 (1.6); 7.9842 (1.6); 7.8958 (1.4); 7.8945 (1.4); 7.7458 (3.3); 7.7410 (1.1); 7.7292 (0.9); 7.7244 (3.1); 7.7202 (0.6); 7.3859 (0.5); 7.2616 (9.2); 5.6837 (0.6); 5.6666 (0.7); 5.6645 (0.7); 5.6474 (0.6); 3.9751 (16.0); 1.4354 (5.1); 1.4186 (5.0); 0.8818 (0.6); -0.0002 (13.4) I.1-16: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6521 (2.6); 8.6460 (3.1); 8.5901 (2.5); 8.5841 (2.1); 8.2352 (3.0); 8.2305 (1.0); 8.2188 (1.0); 8.2139 (3.4); 8.2098 (0.6); 8.1397 (1.4); 8.1345 (1.5); 7.9247 (0.8); 7.9197 (0.7); 7.9040 (0.8); 7.8989 (0.8); 7.7448 (3.2); 7.7400 (1.2); 7.7282 (1.0); 7.7235 (3.1); 7.7192 (0.7); 7.6051 (1.4); 7.5844 (1.2); 7.3572 (0.5); 7.2611 (13.6); 5.6909 (0.6); 5.6716 (0.7); 5.6546 (0.6); 3.9739 (16.0); 1.5773 (0.6); 1.4221 (5.2); 1.4053 (5.1); 0.8818 (0.9); 0.0079 (0.5); -0.0002 (19.8); -0.0085 (0.7) I.1-17: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6586 (2.5); 8.6525 (3.1); 8.5945 (2.4); 8.5884 (2.1); 8.2370 (3.0); 8.2322 (1.0); 8.2205 (1.0); 8.2156 (3.4); 8.2114 (0.6); 7.9369 (1.8); 7.7760 (5.4); 7.7735 (5.5); BCS241005-Abroad STR 118 7.7407 (3.3); 7.7358 (1.1); 7.7241 (1.0); 7.7193 (3.0); 7.7150 (0.6); 7.2605 (29.0); 5.6861 (0.6); 5.6691 (0.7); 5.6498 (0.6); 3.9759 (16.0); 1.5525 (0.9); 1.4209 (5.0); 1.4042 (5.0); 0.0080 (1.1); -0.0002 (42.5); - 0.0085 (1.3) I.1-18: 1H-NMR (400.6 MHz, CDCl3): δ= 9.2077 (0.6); 9.2028 (0.6); 9.0112 (0.5); 9.0078 (0.5); 8.6695 (0.9); 8.6634 (1.1); 8.6025 (0.9); 8.5965 (0.8); 8.3826 (0.6); 8.2443 (1.1); 8.2233 (1.2); 7.7423 (1.2); 7.7213 (1.1); 7.2617 (6.4); 3.9787 (5.4); 2.8085 (16.0); 1.4432 (1.9); 1.4265 (1.9); -0.0002 (9.0) I.1-19:1H-NMR (400.6 MHz, CDCl3): δ= 8.8844 (1.4); 8.8720 (1.4); 8.6731 (2.6); 8.6671 (3.0); 8.6018 (2.6); 8.5958 (2.2); 8.2476 (0.5); 8.2433 (3.2); 8.2386 (1.1); 8.2268 (1.1); 8.2221 (3.6); 8.2179 (0.6); 8.0443 (1.9); 7.8626 (1.0); 7.8592 (1.0); 7.8502 (1.0); 7.8469 (1.0); 7.7370 (0.6); 7.7328 (3.5); 7.7280 (1.2); 7.7163 (1.1); 7.7116 (3.3); 7.7073 (0.5); 7.5647 (0.5); 7.5448 (0.5); 7.2621 (11.9); 5.7050 (0.7); 5.6878 (0.8); 5.6689 (0.7); 3.9792 (16.0); 1.5822 (2.4); 1.4350 (5.5); 1.4183 (5.5); -0.0002 (12.3) I.1-20: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2424 (1.0); 9.2259 (1.0); 8.6905 (2.4); 8.6843 (3.8); 8.6662 (4.3); 8.6602 (2.9); 8.0619 (3.4); 8.0573 (1.1); 8.0455 (1.2); 8.0407 (4.1); 8.0366 (0.7); 8.0226 (1.8); 7.9333 (0.7); 7.9096 (0.7); 7.8833 (0.7); 7.8621 (0.7); 7.7931 (0.6); 7.7891 (3.8); 7.7843 (1.2); 7.7725 (1.1); 7.7678 (3.3); 7.7636 (0.5); 5.3526 (0.7); 5.3357 (1.0); 5.3188 (0.7); 3.3218 (16.0); 2.5251 (1.0); 2.5204 (1.4); 2.5116 (20.1); 2.5071 (44.9); 2.5025 (63.3); 2.4979 (44.3); 2.4933 (19.9); 1.9096 (0.6); 1.4929 (4.1); 1.4756 (4.1); 1.2466 (0.9); 0.8579 (1.8); 0.8403 (0.6); 0.0079 (1.1); -0.0002 (40.3); - 0.0085 (1.2) I.1-21: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2730 (1.3); 9.2565 (1.3); 8.6917 (3.0); 8.6856 (4.7); 8.6671 (5.3); 8.6609 (3.6); 8.2836 (2.3); 8.1405 (2.1); 8.1390 (2.1); 8.1158 (2.2); 8.1143 (2.1); 8.0668 (0.6); 8.0626 (4.1); 8.0580 (1.4); 8.0462 (1.4); 8.0414 (5.0); 8.0373 (0.8); 7.7903 (0.7); 7.7863 (4.6); 7.7815 (1.4); 7.7697 (1.3); 7.7650 (4.1); 7.7608 (0.6); 5.7578 (0.7); 5.3486 (0.8); 5.3318 (1.3); 5.3148 (0.8); 3.3220 (16.0); 2.5253 (1.1); 2.5207 (1.4); 2.5119 (23.4); 2.5073 (52.7); 2.5027 (74.5); 2.4981 (52.4); 2.4936 (23.7); 1.9895 (0.8); 1.9098 (1.0); 1.4907 (4.9); 1.4735 (4.9); 1.2464 (2.0); 0.8747 (1.0); 0.8578 (4.2); 0.8402 (1.4); 0.0080 (1.3); -0.0002 (49.6); -0.0085 (1.5) I.1-22: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2498 (1.2); 9.2333 (1.2); 8.6860 (2.8); 8.6798 (4.5); 8.6631 (5.1); 8.6570 (3.4); 8.2180 (1.8); 8.2128 (2.0); 8.1043 (1.0); 8.0994 (0.9); 8.0836 (1.2); 8.0786 (1.1); 8.0656 (0.6); 8.0613 (3.9); 8.0566 (1.3); 8.0449 (1.3); 8.0400 (4.8); 8.0359 (0.7); 7.8185 (1.9); 7.7974 (1.8); 7.7900 (4.5); 7.7852 (1.4); 7.7735 (1.2); 7.7688 (3.8); 7.7646 (0.6); 5.3490 (0.8); 5.3321 (1.2); 5.3151 (0.8); 4.0388 (0.6); 4.0210 (0.6); 3.3234 (16.0); 2.5257 (0.8); 2.5210 (1.1); 2.5123 (18.6); 2.5077 (42.1); 2.5031 (59.8); 2.4985 (42.0); 2.4939 (19.0); 1.9896 (2.6); 1.9102 (1.2); 1.4838 (4.8); BCS241005-Abroad STR 119 1.4666 (4.8); 1.2585 (0.8); 1.2461 (2.1); 1.1931 (0.8); 1.1753 (1.6); 1.1575 (0.8); 0.8746 (1.1); 0.8577 (4.4); 0.8401 (1.5); 0.0080 (1.1); -0.0002 (41.0); -0.0085 (1.2) I.1-23: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1034 (0.6); 9.2401 (1.2); 9.2236 (1.2); 8.6906 (2.8); 8.6844 (4.6); 8.6672 (5.3); 8.6611 (3.5); 8.0826 (2.4); 8.0716 (4.1); 8.0669 (1.3); 8.0552 (1.4); 8.0503 (5.0); 8.0462 (0.8); 7.9263 (4.1); 7.9199 (2.3); 7.7958 (0.7); 7.7917 (4.6); 7.7869 (1.4); 7.7752 (1.3); 7.7704 (4.0); 7.7663 (0.6); 5.3376 (0.8); 5.3207 (1.2); 5.3037 (0.8); 3.3235 (16.0); 2.5256 (0.9); 2.5209 (1.2); 2.5122 (18.7); 2.5076 (42.1); 2.5030 (59.5); 2.4984 (41.5); 2.4938 (18.5); 1.4832 (4.8); 1.4659 (4.8); 1.2463 (1.3); 0.8746 (0.6); 0.8578 (2.7); 0.8401 (0.9); 0.0080 (1.1); -0.0002 (41.4); -0.0050 (0.6); - 0.0085 (1.2) I.1-24: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3486 (1.6); 9.3321 (1.7); 9.1805 (2.7); 9.1756 (2.8); 9.1015 (2.1); 9.0993 (2.4); 9.0963 (2.4); 9.0945 (2.1); 8.7023 (4.0); 8.6961 (6.2); 8.6769 (7.1); 8.6708 (4.8); 8.5239 (1.6); 8.5203 (2.6); 8.5188 (2.5); 8.5151 (1.5); 8.0696 (0.8); 8.0653 (5.6); 8.0607 (1.8); 8.0489 (1.9); 8.0441 (6.7); 8.0400 (1.0); 7.7993 (1.0); 7.7951 (6.3); 7.7903 (1.9); 7.7786 (1.7); 7.7738 (5.4); 7.7697 (0.8); 5.3818 (1.1); 5.3648 (1.8); 5.3478 (1.1); 3.3272 (16.0); 2.6903 (11.5); 2.5261 (1.1); 2.5214 (1.5); 2.5126 (21.2); 2.5081 (47.4); 2.5035 (66.9); 2.4989 (46.8); 2.4943 (20.9); 1.9898 (0.8); 1.9104 (1.8); 1.5078 (6.8); 1.4906 (6.8); 1.2463 (1.0); 0.8745 (0.5); 0.8577 (2.0); 0.8401 (0.7); 0.0080 (1.2); -0.0002 (43.7); -0.0085 (1.2) I.1-25: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6984 (0.7); 8.6923 (1.2); 8.6761 (1.3); 8.6700 (0.8); 8.1844 (0.6); 8.0615 (1.0); 8.0403 (1.2); 7.7837 (1.1); 7.7625 (1.0); 5.7571 (0.6); 3.3195 (16.0); 2.5241 (0.7); 2.5194 (1.0); 2.5106 (15.8); 2.5061 (35.2); 2.5014 (49.7); 2.4969 (34.9); 2.4923 (15.7); 1.9888 (0.8); 1.5041 (1.2); 1.4869 (1.2); 1.3552 (1.0); 0.0080 (1.0); -0.0002 (34.0); -0.0085 (1.0) I.1-26: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6596 (2.5); 8.6535 (3.1); 8.6074 (2.5); 8.6014 (2.0); 8.2384 (3.1); 8.2336 (1.0); 8.2219 (1.0); 8.2170 (3.3); 8.2128 (0.5); 7.9654 (1.5); 7.9614 (1.0); 7.9402 (1.2); 7.9384 (1.5); 7.9367 (1.4); 7.7467 (1.6); 7.7422 (3.9); 7.7373 (1.0); 7.7256 (1.0); 7.7208 (3.0); 7.2611 (16.7); 5.6859 (0.6); 5.6689 (0.7); 5.6497 (0.6); 3.9757 (16.0); 3.9534 (0.7); 1.5875 (0.7); 1.4304 (5.0); 1.4136 (5.0); 0.0080 (0.7); -0.0002 (23.7); -0.0085 (0.6) I.1-27: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6197 (6.0); 8.2200 (1.6); 8.1986 (1.7); 8.1283 (1.4); 8.1250 (1.5); 8.0086 (1.3); 8.0055 (1.3); 7.7349 (1.5); 7.7135 (1.5); 7.5187 (1.7); 7.2989 (0.6); 7.2710 (0.5); 7.2603 (287.6); 7.2330 (1.0); 7.2267 (0.8); 6.9967 (1.7); 4.0972 (1.5); 3.9757 (1.3); 3.9670 (8.0); 3.9618 (1.6); 3.9507 (0.8); 3.4546 (0.5); 2.3575 (1.4); 2.2936 (0.6); 1.6303 (1.9); 1.4803 (1.0); 1.4417 (2.8); 1.4250 (2.9); 1.3328 (2.0); 1.2842 (3.5); 1.2542 (16.0); 1.2325 (4.1); 0.8801 (2.5); 0.8527 (1.7); 0.8352 BCS241005-Foreign STR 120 (1.3); 0.2383 (0.6); 0.1583 (0.9); 0.1455 (1.4); 0.0686 (0.6); 0.0386 (0.5); 0.0295 (0.6); 0.0080 (9.9); - 0.0002 (428.8); -0.0085 (14.1); -0.0274 (1.7); -0.0339 (1.3); -0.0454 (0.8); -0.1493 (1.3) I.1-28: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7805 (1.4); 8.7789 (1.5); 8.7742 (1.5); 8.7726 (1.5); 8.6557 (2.6); 8.6496 (3.1); 8.5825 (2.4); 8.5764 (2.1); 8.2337 (3.0); 8.2289 (1.0); 8.2172 (1.0); 8.2124 (3.3); 8.2082 (0.5); 7.9904 (1.4); 7.9840 (1.4); 7.9697 (1.5); 7.9634 (1.5); 7.7367 (3.2); 7.7319 (1.0); 7.7202 (0.9); 7.7154 (2.9); 7.5937 (1.8); 7.5920 (1.8); 7.5731 (1.6); 7.5714 (1.6); 7.2611 (22.8); 5.6892 (0.6); 5.6722 (0.7); 5.6530 (0.6); 3.9740 (16.0); 2.0455 (0.9); 1.5798 (1.2); 1.4172 (5.0); 1.4005 (5.0); 1.2597 (0.8); 0.8819 (0.8); 0.0080 (0.9); -0.0002 (32.8); -0.0085 (0.9) I.1-29:1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2710 (1.3); 9.2546 (1.4); 8.6927 (3.2); 8.6866 (5.1); 8.6680 (5.7); 8.6619 (3.9); 8.1428 (2.4); 8.1389 (1.6); 8.0865 (2.4); 8.0850 (2.4); 8.0667 (0.7); 8.0625 (4.6); 8.0579 (1.5); 8.0461 (1.7); 8.0413 (6.8); 8.0369 (2.9); 7.7905 (0.8); 7.7864 (5.0); 7.7816 (1.6); 7.7699 (1.4); 7.7652 (4.4); 7.7610 (0.7); 5.7582 (1.1); 5.3527 (0.9); 5.3358 (1.4); 5.3189 (0.9); 4.0391 (0.6); 4.0214 (0.7); 3.3257 (16.0); 2.5263 (1.0); 2.5217 (1.3); 2.5129 (17.8); 2.5084 (39.6); 2.5037 (55.9); 2.4992 (39.0); 2.4946 (17.4); 1.9900 (3.0); 1.9108 (1.1); 1.4941 (5.4); 1.4769 (5.3); 1.3565 (2.5); 1.2330 (0.5); 1.1934 (1.0); 1.1820 (1.8); 1.1756 (2.1); 1.1702 (0.6); 1.1579 (0.9); 0.0080 (0.7); -0.0002 (22.6); - 0.0085 (0.6) I.1-30: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7299 (0.8); 8.7282 (0.9); 8.7236 (0.9); 8.7218 (0.9); 8.6873 (1.0); 8.6811 (1.6); 8.6630 (1.9); 8.6569 (1.2); 8.0895 (0.7); 8.0832 (0.7); 8.0689 (1.8); 8.0651 (0.6); 8.0624 (0.9); 8.0485 (1.8); 7.7927 (1.6); 7.7880 (0.5); 7.7715 (1.4); 7.7466 (0.9); 7.7450 (0.9); 7.7258 (0.8); 7.7242 (0.9); 5.7570 (3.1); 4.0379 (0.9); 4.0202 (0.9); 3.3206 (16.0); 2.5243 (0.8); 2.5196 (1.0); 2.5108 (14.4); 2.5063 (32.2); 2.5016 (45.4); 2.4971 (31.6); 2.4925 (14.1); 1.9888 (4.3); 1.9088 (1.0); 1.4694 (1.7); 1.4522 (1.7); 1.3552 (0.5); 1.1923 (1.2); 1.1809 (0.7); 1.1746 (2.5); 1.1568 (1.2); - 0.0002 (17.6) I.1-31: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6755 (2.4); 8.6694 (2.8); 8.5967 (2.3); 8.5906 (2.0); 8.2385 (3.0); 8.2336 (1.0); 8.2220 (1.0); 8.2171 (3.3); 8.2129 (0.5); 7.7183 (3.2); 7.7134 (1.0); 7.7017 (0.9); 7.6969 (3.0); 7.2624 (7.6); 7.1943 (5.4); 5.6679 (0.6); 5.6509 (0.7); 5.6488 (0.7); 5.6319 (0.6); 3.9786 (16.0); 1.4111 (5.1); 1.3944 (5.1); 1.2550 (0.8); -0.0002 (11.8) I.1-32: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6792 (0.9); 8.6732 (1.1); 8.6608 (2.1); 8.6547 (2.6); 8.6075 (2.4); 8.6014 (2.0); 8.5946 (1.0); 8.5885 (0.9); 8.3039 (1.6); 8.2377 (2.5); 8.2331 (0.9); 8.2220 (1.7); 8.2168 (3.0); 8.2123 (0.5); 8.2018 (1.3); 8.0780 (1.3); 8.0069 (1.3); 7.7452 (2.8); 7.7405 (0.9); 7.7287 (0.9); 7.7241 (2.6); 7.6623 (1.4); 7.6576 (0.5); 7.6413 (1.2); 7.2610 (19.8); 5.6776 (0.6); 5.6605 (0.6); BCS241005-Abroad STR 121 5.6412 (0.6); 3.9744 (16.0); 2.0459 (1.4); 1.4336 (4.3); 1.4169 (4.3); 1.3749 (2.3); 1.3582 (2.3); 1.2598 (0.9); 0.0079 (0.8); -0.0002 (26.0); -0.0085 (0.8) I.1-33: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6513 (2.5); 8.6452 (3.2); 8.6028 (2.6); 8.5967 (2.0); 8.2319 (3.1); 8.2271 (1.0); 8.2154 (1.0); 8.2106 (3.3); 8.2063 (0.5); 7.7394 (0.5); 7.7352 (3.4); 7.7304 (1.0); 7.7186 (1.0); 7.7138 (3.0); 7.6717 (6.1); 7.6670 (6.4); 7.4993 (1.6); 7.4946 (2.9); 7.4898 (1.4); 7.2605 (32.6); 5.6605 (0.6); 5.6436 (0.7); 5.6242 (0.6); 5.3001 (1.1); 3.9737 (16.0); 1.5529 (3.1); 1.4093 (5.1); 1.3926 (5.1); 0.0079 (1.4); -0.0002 (51.1); -0.0085 (1.4) I.1-34: 1H-NMR (400.6 MHz, CDCl3): δ= 8.8155 (1.0); 8.8112 (1.7); 8.8069 (1.0); 8.6794 (2.6); 8.6733 (3.1); 8.6260 (1.5); 8.6222 (1.0); 8.6176 (2.7); 8.6115 (2.1); 8.4428 (1.6); 8.4414 (1.6); 8.2504 (0.5); 8.2461 (3.2); 8.2413 (1.0); 8.2296 (1.1); 8.2247 (3.5); 8.2206 (0.5); 7.7498 (0.6); 7.7456 (3.4); 7.7408 (1.1); 7.7291 (1.0); 7.7243 (3.1); 7.5995 (0.6); 7.5802 (0.6); 7.2649 (5.2); 5.7190 (0.6); 5.7017 (0.8); 5.6830 (0.6); 5.3006 (10.6); 3.9802 (16.0); 1.6642 (0.6); 1.4618 (5.1); 1.4451 (5.0); -0.0002 (5.9) I.1-35: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6892 (0.7); 8.6671 (0.8); 8.6610 (0.6); 8.0712 (0.6); 8.0499 (0.8); 7.7976 (0.7); 7.7762 (0.7); 3.8920 (2.9); 3.3192 (16.0); 2.5194 (0.6); 2.5106 (8.8); 2.5060 (19.6); 2.5014 (27.9); 2.4968 (19.6); 2.4922 (9.0); 1.4818 (0.8); 1.4646 (0.8); 0.0079 (0.8); -0.0002 (29.7); -0.0044 (0.5); -0.0085 (0.9) I.1-36: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1836 (0.7); 9.1672 (0.8); 8.6881 (1.7); 8.6820 (2.8); 8.6639 (3.2); 8.6578 (2.2); 8.0628 (2.5); 8.0581 (0.8); 8.0464 (0.9); 8.0416 (3.0); 7.9491 (1.2); 7.9449 (1.7); 7.9409 (1.3); 7.7816 (2.7); 7.7768 (0.9); 7.7651 (0.8); 7.7604 (2.5); 7.7549 (0.7); 7.7524 (0.7); 7.7490 (1.1); 7.7447 (0.8); 7.7425 (0.7); 7.7151 (1.1); 7.7122 (1.2); 7.7096 (0.9); 5.3129 (0.8); 3.3216 (16.0); 2.5248 (1.0); 2.5201 (1.3); 2.5113 (18.9); 2.5068 (41.9); 2.5022 (58.9); 2.4976 (41.2); 2.4930 (18.8); 1.9891 (0.9); 1.4783 (2.9); 1.4611 (2.9); 1.3556 (1.2); 1.1749 (0.6); 0.0080 (1.4); -0.0002 (47.9); - 0.0085 (1.4) I.1-37: 1H-NMR (400.6 MHz, CDCl3): δ= 8.8179 (0.9); 8.8135 (1.5); 8.8093 (0.9); 8.6789 (2.3); 8.6728 (2.8); 8.6265 (1.3); 8.6227 (0.9); 8.6159 (2.4); 8.6099 (2.0); 8.4442 (1.4); 8.4429 (1.4); 8.2465 (3.0); 8.2416 (1.0); 8.2300 (1.0); 8.2251 (3.3); 8.2209 (0.6); 7.7495 (0.5); 7.7453 (3.2); 7.7405 (1.0); 7.7288 (1.0); 7.7240 (2.9); 7.7198 (0.5); 7.2647 (5.2); 5.7203 (0.6); 5.7031 (0.7); 5.7015 (0.7); 5.6843 (0.6); 5.3007 (5.7); 3.9803 (16.0); 1.6563 (0.6); 1.4619 (4.7); 1.4451 (4.7); -0.0002 (6.8) I.1-38: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6681 (2.5); 8.6620 (3.0); 8.6076 (2.5); 8.6015 (2.1); 8.5083 (1.8); 8.3789 (1.6); 8.3406 (1.5); 8.3392 (1.6); 8.2452 (2.9); 8.2405 (1.0); 8.2287 (1.0); 8.2239 (3.5); 8.2198 (0.5); 7.7493 (0.5); 7.7451 (3.2); 7.7403 (1.0); 7.7285 (0.9); 7.7238 (3.2); 7.4964 (0.6); 7.4773 BCS241005-Foreign STR 122 (0.6); 7.2620 (20.1); 5.7106 (0.6); 5.6919 (0.8); 5.6747 (0.6); 4.1486 (1.1); 4.1308 (3.4); 4.1130 (3.4); 4.0951 (1.1); 3.9786 (15.1); 3.1441 (14.4); 2.0455 (16.0); 1.5789 (11.7); 1.4554 (4.9); 1.4386 (4.8); 1.2774 (4.4); 1.2596 (8.8); 1.2418 (4.2); 0.0079 (0.7); -0.0002 (22.3); -0.0085 (0.6) I.1-39: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6586 (2.5); 8.6525 (3.0); 8.6011 (2.4); 8.5950 (2.0); 8.2368 (3.0); 8.2320 (1.0); 8.2203 (1.0); 8.2154 (3.3); 7.7378 (3.2); 7.7330 (1.0); 7.7213 (0.9); 7.7165 (2.9); 7.6043 (2.4); 7.5990 (2.4); 7.2613 (16.3); 7.2469 (0.9); 7.2447 (1.0); 7.2424 (0.9); 5.6786 (0.6); 5.6616 (0.7); 5.6425 (0.6); 3.9751 (16.0); 1.5710 (7.7); 1.4210 (4.8); 1.4042 (4.8); -0.0002 (18.4); -0.0085 (0.5) I.1-40: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6579 (0.7); 8.6518 (0.8); 8.6044 (0.6); 8.5984 (0.5); 8.2388 (0.8); 8.2173 (0.9); 7.7450 (0.9); 7.7236 (0.8); 7.2604 (24.9); 6.6042 (0.7); 3.9755 (4.4); 1.5443 (16.0); 1.4333 (1.2); 1.4166 (1.2); 0.0080 (0.8); -0.0002 (28.6); -0.0085 (0.8) I.1-41: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6656 (0.9); 8.6595 (1.1); 8.6107 (0.9); 8.6046 (0.7); 8.2481 (1.1); 8.2247 (1.1); 8.2033 (1.2); 7.7448 (1.2); 7.7235 (1.0); 7.2607 (20.3); 4.6543 (1.1); 4.6385 (0.5); 4.2259 (1.4); 4.2080 (1.4); 2.8377 (0.6); 2.8219 (1.4); 2.8060 (0.6); 1.5514 (16.0); 1.4486 (1.6); 1.4319 (1.6); 1.3082 (1.7); 1.2904 (3.6); 1.2725 (1.9); 1.2657 (0.6); 0.8820 (1.1); 0.0080 (0.7); -0.0002 (22.6); - 0.0085 (0.7) I.1-43: 1H-NMR (400.6 MHz, CDCl3): δ= 9.2204 (3.5); 9.2162 (3.7); 9.2081 (3.6); 9.2039 (3.6); 8.6754 (8.2); 8.6693 (10.3); 8.6230 (8.7); 8.6169 (7.0); 8.3082 (10.0); 8.3035 (3.6); 8.2916 (3.7); 8.2868 (11.2); 8.2473 (11.3); 8.0206 (5.0); 7.7853 (10.7); 7.7806 (3.8); 7.7687 (3.5); 7.7640 (10.1); 7.7156 (3.2); 7.7114 (3.3); 7.6944 (4.4); 7.6902 (4.4); 7.5812 (4.7); 7.5688 (4.7); 7.5601 (3.6); 7.5477 (3.5); 7.5204 (0.5); 7.4713 (2.0); 7.4522 (2.1); 7.2620 (82.0); 5.8201 (0.8); 5.7861 (11.7); 5.7813 (11.8); 5.7471 (0.8); 5.7223 (0.6); 5.7057 (2.1); 5.6867 (2.6); 5.6695 (2.1); 5.6528 (0.6); 5.3005 (15.1); 4.1490 (0.5); 4.1311 (1.7); 4.1132 (1.7); 4.0954 (0.6); 2.1802 (0.5); 2.1325 (2.4); 2.1042 (1.8); 2.0458 (8.4); 1.5832 (10.8); 1.4609 (16.0); 1.4442 (16.0); 1.4242 (1.4); 1.3333 (0.7); 1.2845 (1.2); 1.2776 (2.7); 1.2597 (6.0); 1.2419 (2.4); 0.8802 (0.6); 0.0079 (3.0); -0.0002 (87.8); -0.0085 (2.9) I.1-44: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6851 (6.5); 8.6791 (8.9); 8.6256 (7.3); 8.6194 (7.2); 8.2802 (8.9); 8.2591 (9.9); 7.9074 (6.4); 7.7977 (5.4); 7.7828 (10.2); 7.7616 (9.5); 7.5540 (2.6); 7.5342 (8.0); 7.2626 (78.6); 7.2605 (183.6); 6.9969 (1.2); 6.7972 (3.5); 6.6165 (7.1); 6.4358 (3.5); 5.7356 (2.1); 5.7162 (2.9); 5.6994 (2.3); 2.1271 (1.6); 1.4847 (15.6); 1.4680 (16.0); 1.4322 (3.3); 1.2561 (4.0); 0.1458 (1.0); 0.0079 (3.8); 0.0020 (87.7); -0.0002 (209.3); -0.1489 (1.4) BCS241005-Abroad STR 123 I.1-45: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6850 (8.1); 8.6789 (10.1); 8.6223 (8.7); 8.6162 (7.5); 8.2793 (9.8); 8.2582 (11.0); 7.7752 (10.5); 7.7585 (3.4); 7.7541 (9.7); 7.6315 (9.4); 7.6264 (9.7); 7.5190 (2.5); 7.5030 (2.5); 7.2915 (0.5); 7.2604 (210.9); 6.9968 (1.2); 5.7366 (0.6); 5.7197 (2.0); 5.7017 (2.7); 5.6837 (2.2); 5.6665 (0.6); 4.1496 (0.8); 4.1317 (2.1); 4.1140 (2.2); 4.0961 (0.6); 2.1289 (1.9); 2.0464 (9.6); 1.4700 (16.0); 1.4532 (15.9); 1.2843 (1.2); 1.2779 (3.3); 1.2600 (8.3); 1.2422 (3.4); 0.8803 (1.0); 0.1458 (0.8); 0.0307 (0.7); 0.0148 (0.8); 0.0078 (7.1); -0.0002 (234.7); -0.0085 (8.2); -0.0284 (0.8); -0.1494 (0.9) I.1-46: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7002 (2.8); 8.6941 (3.5); 8.6281 (2.9); 8.6219 (2.5); 8.5479 (2.1); 8.4075 (1.8); 8.3464 (1.8); 8.2973 (3.2); 8.2927 (1.1); 8.2808 (1.1); 8.2761 (3.8); 7.7918 (3.4); 7.7873 (1.2); 7.7707 (3.4); 7.7070 (0.8); 7.6873 (0.9); 7.2607 (68.4); 5.7465 (0.7); 5.7277 (0.8); 5.7100 (0.6); 5.3003 (2.6); 3.1472 (16.0); 2.1307 (1.6); 2.0465 (1.4); 1.5112 (5.0); 1.4944 (5.1); 1.2844 (0.6); 1.2779 (0.7); 1.2599 (2.2); 1.2560 (2.2); 1.2422 (0.7); 0.0080 (2.2); -0.0002 (78.6); -0.0085 (2.5) I.1-47: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6714 (0.6); 8.2739 (0.5); 8.2525 (0.7); 8.2454 (0.5); 7.8147 (0.6); 7.7932 (0.5); 7.2606 (21.8); 5.0259 (1.9); 3.8280 (0.5); 3.7585 (1.4); 3.7425 (1.4); 1.5463 (16.0); 1.4656 (0.8); 1.4488 (0.8); 0.0079 (0.7); -0.0002 (23.5); -0.0085 (0.6) I.1-48: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3019 (0.6); 9.2854 (0.6); 8.7048 (1.5); 8.6987 (2.2); 8.6734 (2.6); 8.6673 (1.9); 8.2542 (1.0); 8.2504 (2.0); 8.2465 (1.2); 8.1621 (1.0); 8.1573 (1.5); 8.1534 (1.1); 8.1120 (1.3); 8.1077 (1.6); 8.1030 (1.0); 8.0844 (2.1); 8.0797 (0.6); 8.0680 (0.7); 8.0630 (2.5); 7.8126 (2.4); 7.8077 (0.7); 7.7960 (0.7); 7.7912 (2.1); 5.7573 (2.6); 5.3277 (0.6); 3.8966 (9.2); 3.3198 (16.0); 3.3095 (8.5); 3.2505 (0.5); 2.5243 (0.8); 2.5196 (1.2); 2.5109 (15.6); 2.5063 (33.7); 2.5017 (47.0); 2.4971 (31.9); 2.4926 (13.7); 1.9888 (1.9); 1.4992 (2.4); 1.4819 (2.3); 1.1924 (0.5); 1.1746 (1.0); 0.0081 (1.3); -0.0002 (49.1); -0.0085 (1.3) I.1-49: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4275 (2.5); 9.4109 (2.5); 8.7003 (5.8); 8.6942 (9.2); 8.6760 (10.4); 8.6699 (6.8); 8.4522 (0.7); 8.4343 (8.5); 8.2817 (3.8); 8.0586 (1.2); 8.0545 (8.2); 8.0498 (2.6); 8.0380 (2.9); 8.0332 (9.8); 8.0291 (1.4); 7.7938 (1.5); 7.7897 (9.3); 7.7850 (2.8); 7.7732 (2.7); 7.7685 (8.0); 7.7643 (1.2); 7.6295 (0.8); 7.6265 (0.5); 7.6177 (0.5); 7.6005 (0.6); 7.5680 (0.6); 5.3945 (1.6); 5.3775 (2.5); 5.3605 (1.6); 4.0395 (1.0); 4.0217 (1.0); 2.9979 (1.2); 2.6731 (0.6); 2.5436 (0.8); 2.5269 (1.5); 2.5222 (2.1); 2.5135 (35.2); 2.5089 (77.7); 2.5043 (108.6); 2.4997 (74.5); 2.4952 (32.8); 2.3314 (0.6); 1.9947 (1.3); 1.9902 (4.6); 1.9110 (16.0); 1.5201 (9.8); 1.5029 (9.7); 1.2592 (0.7); 1.2329 (2.9); 1.1938 (1.7); 1.1760 (3.2); 1.1582 (1.5); 0.8855 (0.6); 0.8773 (0.8); 0.8720 (0.6); 0.8587 (0.5); 0.8530 (0.7); 0.0079 (2.7); 0.0062 (0.7); 0.0053 (0.9); 0.0045 (1.2); -0.0002 (102.2); -0.0052 (1.3); -0.0060 (1.1); -0.0069 (1.0); -0.0085 (3.0) BCS241005-Abroad STR 124 I.1-50: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6961 (6.5); 8.6900 (7.6); 8.6162 (6.6); 8.6101 (5.7); 8.3084 (0.7); 8.2923 (14.5); 8.2757 (3.0); 8.2710 (7.6); 8.0155 (4.0); 7.7810 (7.9); 7.7761 (4.0); 7.7644 (3.0); 7.7598 (7.7); 7.7553 (3.2); 7.7178 (1.4); 7.7135 (8.9); 7.7103 (11.9); 7.7067 (5.1); 7.6982 (3.6); 7.6931 (16.0); 7.6894 (13.6); 7.6834 (9.1); 7.6801 (11.7); 7.6766 (5.1); 7.6681 (3.6); 7.6629 (15.7); 7.6593 (13.3); 7.5800 (1.5); 7.5764 (3.5); 7.5727 (3.5); 7.5691 (1.7); 7.5640 (2.1); 7.5583 (7.4); 7.5540 (7.4); 7.5486 (2.6); 7.5430 (4.2); 7.5394 (9.1); 7.5356 (8.4); 7.5319 (3.1); 7.4955 (8.0); 7.4938 (10.5); 7.4906 (7.0); 7.4882 (8.7); 7.4865 (10.5); 7.4831 (4.8); 7.4783 (8.6); 7.4749 (15.0); 7.4709 (11.5); 7.4675 (14.4); 7.4636 (4.1); 7.4610 (3.0); 7.4572 (6.6); 7.4541 (5.0); 7.4498 (6.2); 7.4470 (3.7); 7.2617 (58.6); 7.2573 (0.8); 7.2566 (0.8); 7.2550 (0.6); 6.2770 (1.0); 6.2629 (1.0); 5.7464 (1.4); 5.7290 (1.8); 5.7105 (1.5); 2.1115 (8.1); 2.0471 (0.5); 1.6441 (0.9); 1.6272 (0.9); 1.5988 (0.7); 1.5960 (0.7); 1.5847 (0.7); 1.5820 (0.7); 1.5011 (10.6); 1.4843 (10.8); 1.4615 (0.7); 1.4208 (4.6); 1.4066 (4.7); 1.3341 (2.9); 1.2846 (4.4); 1.2777 (1.5); 1.2560 (7.2); 1.2373 (1.3); 1.2332 (0.9); 1.1803 (1.2); 1.1644 (1.2); 1.0010 (0.5); 0.9826 (0.6); 0.8968 (0.8); 0.8802 (2.0); 0.8626 (0.9); 0.0080 (1.8); -0.0002 (66.2); -0.0085 (1.9) I.1-51: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3193 (0.7); 9.3029 (0.7); 8.6974 (1.7); 8.6913 (2.5); 8.6700 (3.0); 8.6640 (2.1); 8.2756 (1.2); 8.2717 (2.3); 8.2678 (1.3); 8.1849 (1.2); 8.1801 (1.6); 8.1762 (1.2); 8.1119 (1.4); 8.1077 (1.8); 8.1030 (1.2); 8.0725 (2.3); 8.0678 (0.7); 8.0560 (0.8); 8.0512 (2.8); 7.7956 (2.5); 7.7908 (0.8); 7.7791 (0.7); 7.7743 (2.2); 5.3309 (0.7); 3.3422 (16.0); 3.3113 (9.8); 2.6703 (0.6); 2.5408 (0.8); 2.5240 (1.4); 2.5194 (2.1); 2.5106 (30.0); 2.5061 (65.4); 2.5015 (91.5); 2.4968 (62.5); 2.4923 (27.0); 2.3285 (0.5); 1.4953 (2.6); 1.4781 (2.6); 0.0080 (1.5); -0.0002 (58.0); -0.0028 (1.9); - 0.0044 (0.6); -0.0085 (1.6) I.1-52: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6871 (0.6); 8.6810 (1.0); 8.6606 (1.2); 8.6545 (0.8); 8.0846 (0.9); 8.0632 (1.1); 7.8242 (1.0); 7.8028 (0.9); 7.5688 (0.5); 3.8939 (4.1); 3.3219 (16.0); 2.5113 (6.1); 2.5067 (13.5); 2.5021 (19.0); 2.4975 (13.1); 2.4929 (5.7); 1.4718 (1.1); 1.4546 (1.1); -0.0002 (8.6) I.1-53:1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9710 (0.8); 8.9668 (0.7); 8.7051 (0.7); 8.6990 (1.1); 8.6766 (1.3); 8.6705 (0.9); 8.0791 (1.0); 8.0577 (1.3); 7.8137 (1.2); 7.7923 (1.0); 3.8913 (4.7); 3.3220 (16.0); 2.5201 (0.6); 2.5114 (6.9); 2.5068 (14.7); 2.5023 (20.3); 2.4976 (13.9); 2.4931 (6.0); 1.9892 (1.1); 1.4981 (1.3); 1.4809 (1.2); 1.1749 (0.6); -0.0002 (8.9) I.1-54: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6794 (0.9); 8.6733 (1.5); 8.6568 (1.8); 8.6507 (1.1); 8.0708 (1.3); 8.0495 (1.6); 7.8500 (0.5); 7.8025 (1.5); 7.7812 (1.3); 7.5732 (0.8); 7.5541 (0.6); 3.3226 (16.0); 2.5244 (0.7); 2.5197 (1.0); 2.5110 (14.9); 2.5064 (32.9); 2.5018 (46.2); 2.4972 (31.6); 2.4926 (13.7); 1.9888 (2.4); 1.4688 (1.6); 1.4516 (1.6); 1.1924 (0.7); 1.1746 (1.5); 1.1568 (0.7); 0.0080 (1.4); -0.0002 (50.4); -0.0029 (1.2); -0.0085 (1.3) BCS241005-Foreign STR 125 I.1-55: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2846 (0.7); 9.2680 (0.7); 8.9804 (1.7); 8.9762 (1.7); 8.8089 (0.9); 8.8023 (0.9); 8.6977 (1.6); 8.6916 (2.6); 8.6730 (3.0); 8.6669 (2.0); 8.1721 (0.5); 8.1696 (0.7); 8.1676 (0.8); 8.1653 (1.0); 8.1630 (0.8); 8.1610 (0.6); 8.0645 (2.3); 8.0598 (0.7); 8.0481 (0.8); 8.0432 (2.8); 7.7912 (2.6); 7.7864 (0.8); 7.7747 (0.7); 7.7699 (2.2); 5.3468 (0.7); 3.3221 (16.0); 2.5247 (1.0); 2.5201 (1.4); 2.5113 (18.6); 2.5068 (40.4); 2.5022 (56.4); 2.4976 (38.5); 2.4930 (16.5); 2.1234 (1.0); 1.9891 (2.1); 1.9093 (0.6); 1.4956 (2.7); 1.4784 (2.7); 1.1926 (0.6); 1.1749 (1.2); 1.1571 (0.6); 0.0080 (2.0); 0.0066 (0.6); 0.0057 (0.6); 0.0048 (0.8); -0.0002 (71.2); -0.0085 (1.8) I.1-56: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6866 (8.8); 8.6805 (10.5); 8.6217 (8.6); 8.6157 (7.1); 8.3725 (1.6); 8.2859 (9.7); 8.2812 (3.2); 8.2693 (3.3); 8.2646 (11.1); 8.2256 (1.5); 8.1137 (4.0); 8.1093 (5.7); 8.1052 (4.2); 7.9821 (1.1); 7.9774 (2.2); 7.9352 (5.6); 7.8909 (5.0); 7.8861 (8.1); 7.8813 (3.9); 7.7813 (10.3); 7.7765 (3.2); 7.7600 (9.7); 7.5190 (3.1); 7.5011 (2.0); 7.4806 (2.2); 7.3102 (0.8); 7.2989 (0.8); 7.2900 (1.0); 7.2836 (1.0); 7.2605 (528.8); 7.2572 (11.0); 7.2548 (3.2); 7.2539 (2.9); 7.2532 (2.3); 7.2523 (2.0); 7.2515 (1.8); 7.2492 (1.4); 7.2476 (1.2); 7.2350 (1.2); 7.2292 (1.3); 6.9968 (3.0); 5.7070 (1.9); 5.6882 (2.4); 5.6712 (2.0); 1.6119 (1.8); 1.4717 (16.0); 1.4550 (15.8); 1.3329 (4.2); 1.2842 (5.7); 1.2563 (3.7); 1.1410 (1.5); 1.1254 (1.6); 0.8803 (1.1); 0.1458 (1.8); 0.0382 (0.8); 0.0295 (1.2); 0.0137 (0.9); 0.0121 (1.2); 0.0113 (1.3); 0.0105 (1.8); 0.0096 (2.6); 0.0080 (17.0); 0.0057 (6.6); 0.0049 (8.5); 0.0041 (11.0); -0.0002 (612.8); -0.0057 (6.3); -0.0066 (6.0); -0.0085 (16.8); -0.0129 (2.4); -0.0153 (1.6); -0.0185 (1.2); -0.0217 (1.1); -0.0256 (1.7); -0.0317 (1.5); -0.0502 (0.8); -0.1497 (1.7) I.1-57: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6675 (2.0); 8.6614 (2.5); 8.6101 (2.0); 8.6040 (1.7); 8.2735 (2.4); 8.2687 (0.8); 8.2521 (4.8); 8.0189 (1.0); 7.7500 (2.5); 7.7452 (0.8); 7.7335 (0.8); 7.7287 (2.3); 7.2616 (14.1); 5.6957 (0.6); 5.3002 (3.1); 4.5454 (0.9); 4.5434 (1.0); 4.5357 (1.1); 4.5342 (1.1); 4.5313 (1.0); 4.5292 (1.0); 4.5216 (1.1); 4.5201 (1.0); 3.7791 (1.6); 3.7695 (1.1); 3.7672 (1.7); 3.7555 (1.6); 3.4605 (16.0); 1.5765 (9.2); 1.4446 (3.7); 1.4279 (3.7); -0.0002 (15.2) I.1-58: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6736 (8.7); 8.6675 (10.8); 8.6173 (8.5); 8.6112 (7.0); 8.2721 (1.8); 8.2679 (10.8); 8.2630 (4.1); 8.2530 (10.6); 8.2518 (10.6); 8.2465 (12.4); 8.2423 (1.8); 8.0229 (4.4); 7.7852 (1.8); 7.7810 (11.2); 7.7762 (3.4); 7.7644 (3.3); 7.7596 (10.4); 7.7554 (1.5); 7.4576 (1.7); 7.4375 (1.8); 7.2614 (73.8); 6.9978 (0.5); 5.7313 (2.0); 5.7143 (2.4); 5.6951 (2.0); 5.6784 (0.5); 5.3002 (8.1); 2.7731 (2.1); 2.7607 (2.1); 2.7547 (5.3); 2.7399 (1.7); 2.7351 (2.1); 2.6850 (1.8); 2.6814 (1.9); 2.6667 (5.7); 2.6489 (2.2); 2.2473 (0.7); 2.1949 (1.2); 2.0455 (1.7); 1.9153 (2.0); 1.9089 (2.2); 1.8996 (6.1); 1.8963 (5.7); 1.8902 (7.7); 1.8841 (6.1); 1.8808 (6.0); 1.8714 (2.5); 1.8655 (2.0); 1.5784 (3.8); 1.4622 (15.9); 1.4455 (16.0); 1.3012 (0.6); 1.2825 (0.9); 1.2774 (1.2); 1.2636 (2.3); 1.2597 (2.5); 1.2418 (0.8); 0.8988 (1.2); 0.8819 (4.5); 0.8642 (1.6); 0.0079 (3.4); -0.0002 (117.3); -0.0060 (0.7); -0.0069 (0.6); -0.0085 (3.2) BCS241005-Abroad STR 126 I.1-59: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6637 (2.5); 8.6577 (3.1); 8.6043 (2.9); 8.5981 (2.4); 8.2385 (3.2); 8.2343 (1.0); 8.2224 (1.1); 8.2179 (3.8); 8.2136 (0.6); 8.1390 (1.2); 8.1347 (2.0); 8.1307 (1.4); 8.0553 (2.0); 8.0269 (1.5); 8.0222 (2.3); 8.0177 (1.1); 7.7385 (3.4); 7.7342 (1.1); 7.7224 (1.0); 7.7179 (3.4); 7.7135 (0.5); 7.3628 (0.6); 7.3429 (0.6); 7.2607 (29.2); 5.6762 (0.7); 5.6586 (0.8); 5.6403 (0.7); 3.9755 (16.0); 1.5645 (1.4); 1.4321 (5.5); 1.4154 (5.5); 1.2640 (0.8); 0.8818 (1.4); 0.8639 (0.6); 0.0078 (1.0); -0.0002 (38.6); -0.0085 (1.1) I.1-60: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7007 (8.0); 8.6946 (9.5); 8.6246 (9.0); 8.6184 (7.9); 8.2873 (9.8); 8.2708 (3.4); 8.2663 (11.7); 8.1641 (3.9); 8.1597 (6.4); 8.1557 (4.7); 8.0913 (6.3); 8.0335 (4.8); 8.0289 (7.7); 8.0243 (4.0); 7.7848 (10.7); 7.7804 (3.4); 7.7639 (10.4); 7.5324 (2.2); 7.5184 (2.2); 7.5128 (2.4); 7.2600 (272.6); 7.2299 (0.9); 6.9965 (1.6); 5.7274 (0.6); 5.7113 (2.2); 5.6934 (2.7); 5.6752 (2.2); 5.3000 (7.3); 4.1495 (0.6); 4.1315 (1.3); 4.1136 (1.2); 2.1267 (2.8); 2.0461 (6.3); 1.4848 (15.9); 1.4680 (16.0); 1.4322 (1.1); 1.3326 (1.9); 1.2840 (3.0); 1.2778 (3.1); 1.2560 (11.5); 1.2421 (3.3); 1.2229 (1.8); 0.8800 (2.2); 0.8625 (1.3); 0.1593 (0.6); 0.1456 (1.5); 0.0690 (0.8); 0.0079 (10.0); -0.0002 (388.5); - 0.0085 (12.3); -0.0305 (1.2); -0.1497 (1.4) I.1-61: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6691 (3.9); 8.6630 (4.7); 8.6106 (3.8); 8.6044 (3.1); 8.2755 (0.8); 8.2714 (4.8); 8.2665 (1.6); 8.2499 (9.8); 8.0195 (2.1); 7.7544 (0.9); 7.7502 (5.1); 7.7454 (1.6); 7.7336 (1.6); 7.7289 (4.7); 7.7246 (0.7); 7.4570 (0.8); 7.4378 (0.8); 7.2610 (43.8); 5.7170 (0.9); 5.6999 (1.1); 5.6808 (0.9); 5.3002 (4.4); 4.5397 (1.8); 4.5376 (1.8); 4.5295 (2.3); 4.5281 (2.2); 4.5252 (2.1); 4.5233 (2.1); 4.5153 (2.0); 4.5136 (1.9); 4.1310 (0.5); 4.1132 (0.5); 3.8180 (3.1); 3.8118 (1.0); 3.8079 (2.4); 3.8058 (3.4); 3.8001 (0.9); 3.7938 (2.9); 3.6407 (2.2); 3.6231 (7.2); 3.6057 (7.3); 3.5882 (2.3); 2.1286 (1.2); 2.0456 (2.6); 1.5720 (2.4); 1.4595 (0.6); 1.4487 (7.4); 1.4320 (7.4); 1.2764 (7.6); 1.2589 (16.0); 1.2414 (7.7); 0.0080 (2.2); 0.0064 (0.9); 0.0056 (1.1); -0.0002 (64.3); -0.0050 (0.6); -0.0085 (1.6) I.1-62: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7655 (2.9); 8.7612 (2.9); 8.6667 (6.8); 8.6607 (8.4); 8.6423 (2.3); 8.6382 (2.3); 8.6302 (2.4); 8.6260 (2.3); 8.6127 (6.5); 8.6066 (5.2); 8.2709 (1.3); 8.2667 (8.1); 8.2619 (2.4); 8.2453 (15.2); 8.2418 (7.5); 8.0154 (3.2); 7.8569 (1.3); 7.8525 (1.9); 7.8514 (1.8); 7.8470 (1.2); 7.8372 (1.4); 7.8330 (2.0); 7.8317 (1.9); 7.8274 (1.3); 7.7678 (1.4); 7.7636 (8.4); 7.7587 (2.4); 7.7470 (2.5); 7.7422 (7.5); 7.7379 (1.1); 7.4646 (1.3); 7.4450 (1.3); 7.3878 (1.8); 7.3857 (1.7); 7.3756 (1.8); 7.3736 (1.7); 7.3682 (1.7); 7.3662 (1.6); 7.3560 (1.7); 7.3540 (1.5); 7.2622 (30.9); 5.6977 (1.5); 5.6806 (1.7); 5.6785 (1.6); 5.6614 (1.4); 5.4432 (12.8); 5.2997 (10.1); 4.1488 (0.7); 4.1310 (2.1); 4.1131 (2.1); 4.0953 (0.7); 2.2616 (0.8); 2.2477 (1.1); 2.1948 (2.0); 2.1035 (1.7); 2.0455 (10.3); 1.4494 (11.6); 1.4326 (11.5); 1.3214 (0.7); 1.3036 (1.6); 1.2907 (1.8); 1.2861 (2.0); 1.2832 (2.0); 1.2773 (5.2); 1.2645 (7.8); 1.2595 (11.0); 1.2447 (1.5); 1.2416 (3.9); 1.2273 (0.5); 0.8988 (4.2); 0.8819 (16.0); 0.8642 (5.8); 0.0080 (1.4); -0.0002 (48.9); -0.0085 (1.2) BCS241005-Abroad STR 127 I.1-63: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6784 (1.4); 8.6723 (1.7); 8.6356 (1.0); 8.6326 (1.9); 8.6290 (4.4); 8.6258 (1.4); 8.6078 (1.4); 8.6016 (1.2); 8.5325 (0.6); 8.2478 (1.7); 8.2313 (2.0); 8.2267 (2.9); 7.7421 (1.8); 7.7373 (0.6); 7.7208 (1.8); 7.5187 (0.6); 7.2603 (92.0); 4.1309 (0.5); 4.1131 (0.6); 3.9803 (8.8); 3.1604 (16.0); 3.1378 (6.6); 2.0454 (2.6); 1.5493 (6.3); 1.4618 (2.6); 1.4450 (2.6); 1.2842 (0.6); 1.2775 (0.9); 1.2596 (1.9); 1.2418 (0.7); 0.0079 (3.6); -0.0002 (139.8); -0.0085 (4.0) I.1-64: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6238 (1.4); 8.6197 (1.6); 8.5784 (1.5); 8.5745 (1.3); 8.2176 (2.0); 8.2038 (2.1); 7.7445 (2.0); 7.7307 (1.9); 7.6441 (1.5); 7.6418 (1.5); 7.4422 (0.7); 7.4395 (0.7); 7.4287 (0.8); 7.4260 (0.8); 7.2601 (36.6); 7.2488 (1.4); 7.2353 (1.2); 7.2114 (0.4); 7.1981 (0.4); 5.6568 (0.4); 5.6447 (0.6); 5.6327 (0.4); 4.5458 (5.7); 3.9680 (8.3); 3.2126 (0.4); 3.2088 (0.4); 1.5577 (2.2); 1.4004 (0.4); 1.3883 (3.3); 1.3771 (3.1); 1.3598 (0.3); 1.2529 (0.8); -0.0001 (50.0); -0.0055 (2.4) I.1-64: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6216 (3.8); 8.5759 (3.6); 8.2197 (4.1); 8.2015 (4.7); 7.7469 (4.6); 7.7284 (4.3); 7.6423 (4.1); 7.4438 (1.8); 7.4236 (2.3); 7.2608 (22.6); 7.2301 (2.4); 7.2018 (1.3); 5.6612 (1.1); 5.6436 (1.6); 5.6263 (1.1); 4.5457 (9.3); 3.9683 (16.0); 1.6027 (0.9); 1.4194 (0.8); 1.3911 (6.5); 1.3745 (6.7); 1.3582 (0.7); 1.2531 (0.6); -0.0002 (31.1) I.1-65: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6203 (2.3); 8.6163 (2.7); 8.5790 (2.6); 8.5751 (2.2); 8.2171 (3.2); 8.2032 (3.4); 7.7490 (3.3); 7.7351 (3.1); 7.5923 (2.4); 7.5894 (2.3); 7.4117 (1.2); 7.4086 (1.1); 7.3980 (1.4); 7.3949 (1.3); 7.2602 (37.4); 7.2008 (0.9); 7.1937 (2.6); 7.1885 (1.0); 7.1801 (2.1); 5.6582 (0.7); 5.6465 (1.0); 5.6341 (0.7); 3.9732 (1.0); 3.9667 (13.3); 3.9532 (0.3); 3.3294 (1.0); 3.3240 (1.8); 3.3208 (1.5); 3.3163 (1.8); 3.3125 (2.2); 3.3107 (2.1); 3.2872 (2.2); 3.2853 (2.1); 3.2815 (1.8); 3.2770 (1.7); 3.2742 (1.7); 3.2685 (1.1); 1.5800 (2.2); 1.3918 (5.2); 1.3806 (5.2); 1.3713 (0.5); 1.3600 (0.3); - 0.0001 (50.0) I.1-67: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.5255 (0.6); 9.5089 (0.7); 8.7108 (1.4); 8.7046 (2.1); 8.6815 (2.3); 8.6754 (1.9); 8.6699 (0.9); 8.6528 (3.7); 8.6486 (4.0); 8.4957 (1.0); 8.4916 (1.9); 8.4874 (1.0); 8.4333 (0.7); 8.2540 (1.6); 8.2498 (1.5); 8.0840 (1.9); 8.0794 (0.6); 8.0675 (0.6); 8.0628 (2.4); 7.8161 (2.1); 7.8114 (0.7); 7.7996 (0.6); 7.7949 (2.0); 5.3705 (0.6); 4.0379 (0.6); 4.0201 (0.6); 3.4101 (2.8); 3.3994 (5.9); 3.3637 (14.8); 2.5410 (16.7); 2.5242 (1.0); 2.5195 (1.3); 2.5107 (19.4); 2.5062 (42.6); 2.5016 (59.2); 2.4970 (41.1); 2.4924 (18.1); 1.9887 (2.8); 1.9088 (16.0); 1.5253 (2.3); 1.5080 (2.3); 1.2586 (0.5); 1.2348 (2.2); 1.1924 (1.2); 1.1746 (1.8); 1.1568 (0.8); 0.0080 (1.8); 0.0057 (0.7); -0.0002 (57.7); -0.0085 (1.4) BCS241005-Abroad STR 128 I.1-69: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6362 (2.8); 8.6302 (3.0); 8.5268 (2.2); 8.5207 (2.0); 8.2397 (3.3); 8.2384 (1.9); 8.2348 (1.0); 8.2232 (1.2); 8.2194 (2.4); 8.2182 (3.4); 7.7145 (0.5); 7.7104 (3.4); 7.7054 (1.0); 7.6937 (1.2); 7.6889 (3.6); 7.6847 (0.6); 7.6692 (0.9); 7.6673 (0.7); 7.2614 (18.0); 5.7782 (0.6); 5.7615 (0.6); 5.7575 (0.6); 5.7409 (0.5); 3.9713 (16.0); 1.5615 (0.5); 1.4029 (4.4); 1.3863 (4.4); 1.2552 (0.5); 0.0080 (0.6); -0.0002 (21.0); -0.0085 (0.6) I.1-70: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6442 (2.6); 8.6381 (3.2); 8.5900 (2.9); 8.5840 (2.3); 8.2289 (3.4); 8.2243 (1.3); 8.2122 (1.4); 8.2077 (3.7); 8.0562 (2.8); 8.0511 (2.7); 7.7410 (3.7); 7.7364 (1.3); 7.7243 (1.4); 7.7199 (3.4); 7.7033 (2.1); 7.6826 (3.1); 7.6006 (1.8); 7.5954 (1.7); 7.5799 (1.2); 7.5747 (1.2); 7.3095 (0.7); 7.2898 (0.7); 7.2620 (8.1); 5.6652 (0.8); 5.6482 (1.0); 5.6291 (0.8); 3.9716 (16.0); 2.0453 (0.6); 1.5886 (1.0); 1.4082 (5.7); 1.3915 (5.7); -0.0002 (10.2) I.1-71: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1227 (0.7); 9.0909 (2.8); 9.0747 (2.9); 8.6810 (4.4); 8.6754 (6.1); 8.6561 (6.2); 8.6505 (4.4); 8.1739 (6.3); 8.1700 (6.2); 8.0728 (6.5); 8.0524 (7.5); 7.9209 (0.8); 7.9003 (1.1); 7.8336 (4.0); 7.8128 (5.6); 7.7940 (7.6); 7.7737 (6.5); 7.7167 (3.3); 7.7126 (3.1); 7.6961 (2.3); 7.6915 (2.3); 5.3095 (1.7); 5.2926 (2.5); 5.2757 (1.7); 3.3260 (16.0); 2.6732 (0.5); 2.5039 (85.6); 1.4599 (9.5); 1.4428 (9.5); 1.2332 (1.1); -0.0002 (35.1) I.1-72: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6211 (2.3); 8.6171 (2.5); 8.5736 (2.4); 8.5698 (2.1); 8.2322 (3.0); 8.2184 (3.3); 7.7323 (3.3); 7.7185 (3.1); 7.6573 (2.3); 7.6551 (2.4); 7.4522 (1.1); 7.4496 (1.2); 7.4387 (1.3); 7.4361 (1.3); 7.3151 (0.9); 7.3015 (1.0); 7.2847 (36.4); 7.2481 (2.1); 7.2347 (1.8); 5.6572 (0.7); 5.6452 (1.0); 5.6334 (0.7); 4.5467 (8.7); 3.2113 (0.4); 3.2076 (0.4); 2.5839 (0.6); 2.0348 (0.3); 1.9511 (0.3); 1.3952 (5.0); 1.3841 (4.7); 1.2535 (0.8); -0.0001 (50.0); -0.0229 (0.3) I.1-73: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6479 (3.2); 8.6440 (3.8); 8.6043 (3.6); 8.6005 (3.1); 8.2313 (4.2); 8.2175 (4.6); 7.7536 (4.5); 7.7399 (4.3); 7.6325 (3.4); 7.6297 (3.6); 7.4518 (1.7); 7.4488 (1.7); 7.4381 (2.0); 7.4350 (2.0); 7.4251 (1.6); 7.4119 (1.6); 7.2602 (36.0); 7.2057 (3.1); 7.1919 (2.8); 5.7400 (1.0); 5.7279 (1.4); 5.7158 (1.1); 3.3341 (1.6); 3.3280 (2.5); 3.3210 (2.4); 3.3171 (2.9); 3.3150 (2.8); 3.2896 (2.7); 3.2875 (3.0); 3.2836 (2.5); 3.2766 (2.5); 3.2704 (1.6); 1.4647 (7.2); 1.4535 (7.2); 1.2531 (1.1); -0.0001 (50.0) BCS241005-Abroad STR 129 I.1-74: 1H-NMR(600.3 MHz, d6-DMSO): δ= 8.8897 (1.3); 8.8786 (1.3); 8.7235 (0.3); 8.7195 (0.4); 8.6987 (0.4); 8.6947 (0.3); 8.6761 (2.2); 8.6722 (2.9); 8.6499 (3.0); 8.6459 (2.3); 8.0906 (3.3); 8.0767 (3.7); 7.8405 (3.6); 7.8267 (3.2); 7.7377 (0.5); 7.7237 (0.6); 7.6419 (1.1); 7.6390 (1.3); 7.6282 (1.1); 7.6254 (1.6); 7.6169 (2.8); 7.2367 (2.0); 7.2229 (1.9); 5.3178 (0.8); 5.3065 (1.2); 5.2951 (0.8); 3.8986 (13.0); 3.8893 (0.4); 3.6012 (0.3); 3.3190 (19.6); 2.8903 (0.6); 2.7310 (0.5); 2.5364 (0.5); 2.5187 (0.8); 2.5009 (50.0); 2.4806 (0.3); 1.7598 (0.4); 1.4558 (4.7); 1.4442 (5.1); 1.4311 (0.8); 1.2350 (0.4); 1.1733 (0.3); -0.0001 (21.6) I.1-75: 1H-NMR(600.3 MHz, d6-DMSO): δ= 8.7435 (2.3); 8.7325 (2.3); 8.7235 (0.3); 8.7195 (0.4); 8.6987 (0.4); 8.6949 (0.3); 8.6677 (4.1); 8.6637 (5.3); 8.6406 (5.6); 8.6366 (4.2); 8.0872 (6.3); 8.0735 (7.0); 7.9528 (0.4); 7.8249 (6.8); 7.8111 (6.1); 7.7376 (0.4); 7.7240 (0.4); 7.5112 (0.6); 7.5090 (0.6); 7.4980 (0.7); 7.4956 (0.7); 7.4102 (1.2); 7.4007 (2.2); 7.3981 (2.6); 7.3874 (3.0); 7.3850 (3.1); 7.3285 (5.1); 7.3152 (3.6); 7.2834 (5.2); 7.2811 (5.0); 5.8408 (4.2); 5.8030 (17.2); 5.2849 (0.4); 5.2738 (1.6); 5.2624 (2.4); 5.2511 (1.6); 5.2396 (0.4); 3.9129 (0.4); 3.8998 (24.6); 3.8893 (0.6); 3.6011 (0.6); 3.3263 (8.1); 2.8902 (2.1); 2.7309 (1.9); 2.5038 (37.5); 2.5011 (50.0); 2.4984 (37.5); 1.7597 (0.7); 1.4845 (0.5); 1.4424 (0.8); 1.4258 (9.0); 1.4143 (9.0); 0.9419 (0.5); 0.0170 (0.4); -0.0001 (38.0) I.1-76: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6152 (0.8); 8.6111 (1.0); 8.5707 (0.9); 8.5667 (0.8); 8.2146 (1.2); 8.2008 (1.2); 7.7484 (1.2); 7.7346 (1.1); 7.2975 (0.4); 7.2839 (0.6); 7.2736 (1.0); 7.2705 (0.8); 7.2600 (38.3); 7.1007 (0.8); 7.0873 (0.7); 4.4344 (0.7); 4.4266 (0.7); 4.4188 (0.7); 3.9707 (0.8); 3.9662 (4.9); 3.1697 (0.7); 3.1619 (0.7); 3.1542 (0.7); 1.5527 (2.6); 1.3842 (1.8); 1.3730 (1.8); 1.2529 (0.9); 0.0691 (1.7); 0.0178 (0.3); 0.0053 (1.9); -0.0001 (50.0); -0.0054 (1.5) I.1-77: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6480 (1.5); 8.6440 (1.7); 8.5809 (1.6); 8.5768 (1.5); 8.2209 (2.2); 8.2099 (0.8); 8.2069 (2.4); 7.7660 (2.2); 7.7631 (0.8); 7.7520 (2.2); 7.5558 (1.6); 7.5522 (1.7); 7.4515 (0.9); 7.4478 (0.8); 7.4373 (0.9); 7.4336 (0.9); 7.2603 (38.2); 7.2180 (0.4); 7.2045 (0.5); 6.8547 (1.7); 6.8405 (1.6); 5.6606 (0.5); 5.6479 (0.6); 5.6362 (0.5); 4.4657 (1.4); 4.4603 (0.9); 4.4579 (1.4); 4.4555 (0.9); 4.4501 (1.5); 3.9734 (0.5); 3.9672 (10.5); 3.1495 (1.5); 3.1443 (0.9); 3.1417 (1.4); 3.1393 (0.9); 3.1340 (1.5); 2.9588 (0.6); 2.8859 (0.6); 2.0345 (0.3); 1.9947 (0.6); 1.5642 (0.6); 1.5473 (1.2); 1.5361 (1.1); 1.4544 (1.2); 1.4434 (1.2); 1.4111 (3.6); 1.3998 (3.6); 1.2529 (0.7); 1.0264 (0.3); 0.0053 (1.6); -0.0001 (50.0); -0.0056 (1.6); -0.0209 (0.3) BCS241005-Foreign STR 130 I.1-78: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6756 (0.5); 8.6715 (0.6); 8.6210 (4.5); 8.6170 (5.5); 8.5919 (0.5); 8.5878 (0.6); 8.5786 (5.0); 8.5746 (4.3); 8.2175 (6.4); 8.2038 (6.6); 8.0191 (0.7); 7.7494 (6.2); 7.7355 (5.8); 7.6579 (0.8); 7.6426 (4.6); 7.6395 (4.6); 7.4860 (2.3); 7.4828 (2.3); 7.4721 (2.5); 7.4689 (2.4); 7.2674 (0.4); 7.2607 (38.2); 7.2527 (0.5); 7.1820 (1.2); 7.1689 (1.3); 6.8400 (4.4); 6.8261 (4.2); 5.7589 (20.4); 5.6715 (0.3); 5.6602 (1.3); 5.6486 (1.6); 5.6359 (1.3); 5.6247 (0.4); 4.1280 (0.3); 4.1161 (0.3); 3.9732 (3.5); 3.9677 (27.6); 3.9599 (0.8); 3.9532 (0.5); 2.9565 (5.9); 2.8845 (5.3); 2.0449 (1.4); 1.5665 (1.9); 1.3886 (9.9); 1.3775 (10.1); 1.3711 (1.7); 1.3599 (1.3); 1.2713 (0.5); 1.2594 (1.0); 1.2536 (0.6); 1.2476 (0.5); 0.0696 (0.3); 0.0053 (1.7); -0.0001 (50.0); -0.0055 (2.3) I.1-83: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6821 (1.0); 8.6760 (1.4); 8.6532 (1.7); 8.6472 (1.2); 8.0829 (1.4); 8.0615 (1.6); 7.8152 (1.6); 7.7938 (1.3); 7.5737 (0.6); 7.5695 (0.8); 7.5649 (0.7); 7.3821 (0.5); 7.3784 (1.0); 7.3746 (0.5); 7.3007 (0.6); 7.2963 (0.9); 3.8982 (6.3); 3.3180 (16.0); 2.5237 (1.1); 2.5190 (1.5); 2.5103 (22.0); 2.5057 (48.2); 2.5011 (67.6); 2.4965 (46.3); 2.4920 (20.1); 1.4586 (1.6); 1.4413 (1.6); 0.9945 (0.6); 0.9889 (0.7); 0.9734 (0.6); 0.9679 (0.6); 0.8582 (0.6); 0.7495 (0.6); 0.7454 (0.5); 0.7372 (0.5); 0.0079 (0.9); -0.0002 (32.3); -0.0027 (1.1); -0.0085 (0.9) I.1-84:1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6710 (0.5); 8.6643 (0.6); 8.6476 (0.7); 8.0787 (0.6); 8.0575 (0.6); 7.8214 (0.6); 3.8983 (1.3); 3.3184 (16.0); 2.5236 (1.1); 2.5189 (1.5); 2.5102 (18.8); 2.5056 (42.1); 2.5011 (61.0); 2.4964 (38.9); 2.4919 (16.8); 1.4570 (0.8); 1.4398 (0.8); 0.0079 (1.0); -0.0002 (35.0); -0.0085 (1.0) I.1-85:1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7583 (1.4); 8.7417 (1.5); 8.6629 (3.6); 8.6567 (5.0); 8.6388 (5.9); 8.6327 (3.8); 8.0917 (0.5); 8.0742 (4.7); 8.0699 (1.9); 8.0577 (1.7); 8.0529 (5.4); 7.8293 (0.6); 7.8054 (5.1); 7.8006 (1.6); 7.7888 (1.6); 7.7842 (4.4); 7.4160 (1.7); 7.4121 (1.7); 7.3961 (2.5); 7.3920 (2.8); 7.3350 (4.3); 7.3150 (2.7); 7.2985 (3.7); 7.2948 (3.4); 7.2858 (0.6); 5.8412 (1.8); 5.8046 (16.0); 5.2862 (0.9); 5.2695 (1.4); 5.2525 (0.9); 3.8998 (2.1); 3.7847 (0.6); 2.6749 (0.7); 2.6703 (1.0); 2.6658 (0.7); 2.5328 (0.9); 2.5281 (1.5); 2.5240 (3.6); 2.5194 (4.8); 2.5106 (59.3); 2.5061 (126.7); 2.5015 (174.5); 2.4969 (119.8); 2.4924 (52.0); 2.4680 (0.5); 2.3331 (0.8); 2.3286 (1.0); 2.3240 (0.7); 1.4276 (5.8); 1.4104 (5.8); 0.0080 (3.0); -0.0002 (97.7); -0.0059 (0.9); -0.0068 (0.8); -0.0085 (2.7) BCS241005-Abroad STR 131 I.1-87: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7224 (3.6); 8.7059 (3.7); 8.6601 (8.6); 8.6539 (13.3); 8.6352 (16.0); 8.6291 (11.1); 8.0753 (12.2); 8.0706 (3.9); 8.0588 (4.4); 8.0540 (14.7); 8.0499 (2.1); 7.8085 (13.6); 7.8036 (4.1); 7.7919 (3.9); 7.7872 (11.7); 7.7830 (1.7); 7.6227 (9.4); 7.6173 (9.8); 7.4683 (5.6); 7.4629 (4.9); 7.4470 (5.9); 7.4415 (5.7); 6.8291 (10.9); 6.8078 (10.4); 5.2764 (2.3); 5.2595 (3.6); 5.2426 (2.4); 4.4032 (5.5); 4.3951 (4.7); 4.3917 (5.5); 4.3880 (4.6); 4.3801 (5.5); 3.9004 (0.5); 3.4359 (3.6); 3.2096 (5.9); 3.2017 (4.6); 3.1981 (5.7); 3.1945 (4.5); 3.1866 (5.3); 2.6753 (1.0); 2.6706 (1.4); 2.6660 (1.0); 2.5244 (4.5); 2.5197 (6.2); 2.5110 (79.4); 2.5064 (171.2); 2.5018 (237.6); 2.4972 (162.2); 2.4927 (70.1); 2.4711 (1.0); 2.4665 (1.1); 2.3335 (1.0); 2.3289 (1.4); 2.3243 (1.0); 1.4233 (14.2); 1.4060 (14.1); 0.0268 (0.6); 0.0080 (4.4); -0.0002 (155.6); -0.0053 (1.0); -0.0061 (0.9); -0.0070 (0.8); -0.0085 (4.0); -0.0309 (0.5) I.1-88: 1H-NMR (400.6 MHz, CDCl3): δ= 8.0523 (0.8); 8.0311 (0.9); 7.6924 (0.7); 7.6739 (0.5); 7.6715 (1.0); 7.6692 (0.6); 7.5736 (0.6); 7.5712 (0.6); 7.4530 (0.5); 7.4503 (0.5); 7.4321 (0.6); 7.2601 (42.0); 6.2278 (6.9); 2.6383 (0.6); 1.5382 (16.0); 0.0080 (1.4); -0.0002 (45.9); -0.0085 (1.3) I.1-89:1H-NMR (400.6 MHz, CDCl3): δ= 8.6353 (2.3); 8.6293 (3.1); 8.5917 (2.4); 8.5857 (1.9); 8.2373 (2.9); 8.2325 (1.0); 8.2208 (1.0); 8.2159 (3.4); 8.2117 (0.5); 8.1466 (0.9); 8.1420 (1.6); 8.1373 (1.0); 8.0074 (1.6); 8.0060 (1.8); 8.0011 (1.7); 7.9998 (1.7); 7.9003 (0.6); 7.8978 (0.7); 7.8947 (0.6); 7.8921 (0.7); 7.8801 (0.8); 7.8775 (0.8); 7.8744 (0.8); 7.8719 (0.7); 7.7709 (3.2); 7.7659 (1.0); 7.7564 (1.8); 7.7534 (2.2); 7.7510 (2.5); 7.7495 (3.2); 7.7292 (0.6); 7.7265 (0.8); 7.7225 (0.6); 7.7098 (0.8); 7.7058 (1.0); 7.7032 (0.8); 7.5569 (1.1); 7.5373 (1.8); 7.5184 (1.1); 7.2602 (85.9); 6.5088 (1.5); 6.5043 (1.6); 6.5026 (1.7); 6.4981 (1.5); 5.7223 (0.6); 5.7055 (0.6); 5.6858 (0.6); 3.9726 (16.0); 1.5512 (4.9); 1.4390 (4.7); 1.4222 (4.7); 0.0079 (3.2); -0.0002 (123.3); -0.0085 (3.5) I.1-90: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6622 (2.4); 8.6561 (3.1); 8.6052 (2.6); 8.5991 (2.2); 8.2445 (4.9); 8.2400 (7.5); 8.2228 (1.1); 8.2180 (3.7); 8.2141 (2.4); 8.2099 (2.8); 8.2056 (1.2); 7.7383 (3.2); 7.7335 (1.1); 7.7217 (0.9); 7.7170 (3.1); 7.5186 (0.7); 7.4064 (0.6); 7.3859 (0.6); 7.2602 (133.3); 6.9966 (0.7); 5.6816 (0.6); 5.6625 (0.8); 5.6454 (0.6); 4.1310 (1.1); 4.1132 (1.1); 3.9768 (16.0); 3.1194 (1.6); 3.1080 (14.9); 2.0455 (5.1); 1.5459 (3.4); 1.4356 (4.9); 1.4189 (4.9); 1.2776 (1.5); 1.2598 (3.1); 1.2419 (1.5); 0.8638 (1.1); 0.8589 (1.8); 0.8360 (0.5); 0.8330 (0.6); 0.1457 (0.6); 0.0296 (0.6); 0.0112 (1.0); 0.0105 (0.9); 0.0080 (4.9); 0.0057 (1.6); 0.0048 (2.0); -0.0002 (183.5); -0.0065 (1.7); -0.0085 (5.1); -0.1494 (0.5) BCS241005-Abroad STR 132 I.1-94: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6920 (2.7); 8.6859 (3.1); 8.6179 (2.6); 8.6118 (2.2); 8.5304 (1.8); 8.5263 (2.2); 8.5257 (2.2); 8.5216 (1.7); 8.4457 (0.7); 8.3909 (0.6); 8.3519 (1.8); 8.3469 (3.0); 8.3419 (1.5); 8.2686 (0.6); 8.2443 (3.2); 8.2395 (1.0); 8.2277 (1.1); 8.2229 (3.5); 8.2187 (0.5); 8.1764 (0.5); 8.1728 (0.6); 8.1690 (1.8); 8.1648 (2.3); 8.1604 (1.6); 7.7543 (0.9); 7.7500 (3.4); 7.7452 (1.1); 7.7334 (1.0); 7.7286 (3.1); 7.6212 (0.6); 7.6017 (0.6); 7.2628 (8.8); 5.6966 (0.7); 5.6794 (0.8); 5.6606 (0.6); 3.9783 (16.0); 3.1506 (0.5); 3.0210 (0.5); 1.4594 (5.0); 1.4426 (5.0); -0.0002 (14.2) I.1-95: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6748 (0.9); 8.6687 (1.4); 8.6498 (1.7); 8.6437 (1.1); 8.0698 (1.3); 8.0485 (1.5); 7.7957 (1.4); 7.7744 (1.2); 7.5954 (0.6); 7.5913 (0.9); 7.5866 (0.6); 7.3991 (0.5); 7.3953 (0.9); 7.3915 (0.5); 7.3030 (0.6); 7.2985 (0.9); 4.0378 (0.5); 4.0201 (0.5); 3.3191 (16.0); 2.5238 (1.0); 2.5192 (1.5); 2.5105 (21.5); 2.5059 (46.9); 2.5013 (65.4); 2.4967 (44.7); 2.4921 (19.4); 1.9887 (2.5); 1.9085 (0.5); 1.4557 (1.5); 1.4385 (1.5); 1.1923 (0.7); 1.1745 (1.5); 1.1567 (0.7); 0.9951 (0.6); 0.9894 (0.7); 0.9740 (0.6); 0.9684 (0.7); 0.7553 (0.6); 0.7522 (0.5); 0.0080 (0.8); -0.0002 (26.2); - 0.0026 (0.9); -0.0085 (0.6) I.1-96: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6455 (2.5); 8.6394 (3.2); 8.5934 (2.4); 8.5873 (2.0); 8.5277 (2.3); 8.5222 (2.3); 8.2316 (3.0); 8.2268 (0.9); 8.2151 (1.0); 8.2102 (3.3); 7.9967 (1.2); 7.9912 (1.1); 7.9761 (1.6); 7.9706 (1.6); 7.8779 (2.7); 7.8573 (1.9); 7.7495 (0.5); 7.7453 (3.3); 7.7404 (1.0); 7.7287 (1.0); 7.7239 (3.0); 7.2647 (9.4); 5.6848 (0.6); 5.6677 (0.7); 5.6658 (0.6); 5.6486 (0.6); 4.1486 (0.8); 4.1307 (2.4); 4.1129 (2.5); 4.0951 (0.8); 3.9730 (15.8); 3.3202 (16.0); 2.1265 (0.6); 2.0456 (12.2); 1.6332 (1.0); 1.4298 (4.7); 1.4182 (0.8); 1.4130 (4.7); 1.2773 (3.5); 1.2595 (7.1); 1.2417 (3.4); 0.8591 (0.6); - 0.0002 (11.8) I.1-97: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.0992 (0.8); 9.3866 (1.5); 9.3702 (1.5); 8.6979 (3.1); 8.6918 (4.6); 8.6712 (5.0); 8.6652 (3.4); 8.5703 (2.2); 8.5654 (3.0); 8.5615 (2.4); 8.4244 (2.2); 8.4195 (4.0); 8.4144 (2.1); 8.2895 (2.4); 8.2853 (3.3); 8.2810 (2.2); 8.0632 (4.3); 8.0589 (1.6); 8.0467 (1.7); 8.0422 (5.2); 7.7847 (4.9); 7.7802 (1.7); 7.7681 (1.6); 7.7637 (4.3); 5.3558 (1.0); 5.3389 (1.5); 5.3219 (1.0); 3.3256 (16.0); 2.5259 (1.0); 2.5211 (1.5); 2.5124 (17.0); 2.5080 (35.7); 2.5034 (48.6); 2.4989 (34.3); 2.4944 (15.7); 1.5037 (5.6); 1.4864 (5.6); 1.2330 (0.9); -0.0002 (8.7) I.1-98:1H-NMR (400.6 MHz, CDCl3): δ= 8.6460 (2.5); 8.6399 (3.2); 8.5962 (2.3); 8.5901 (1.9); 8.2873 (2.0); 8.2816 (2.2); 8.2313 (3.0); 8.2265 (0.9); 8.2148 (0.9); 8.2099 (3.3); 8.0884 (1.1); 8.0826 (1.1); 8.0665 (1.2); 8.0607 (1.2); 7.7461 (3.0); 7.7413 (0.9); 7.7296 (0.9); 7.7247 (2.8); 7.2609 (33.0); 7.1632 (1.7); 7.1411 (1.6); 5.6851 (0.5); 5.6683 (0.6); 5.6489 (0.5); 4.0231 (12.9); 3.9727 (16.0); 2.1347 (0.6); 1.5573 (2.7); 1.4244 (0.5); 1.4186 (4.5); 1.4018 (4.5); 0.0079 (1.2); -0.0002 (41.9); -0.0027 (1.8); -0.0044 (0.6); -0.0085 (1.2) BCS241005-Abroad STR 133 I.1-99: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1000 (0.7); 9.0507 (0.9); 9.0343 (0.9); 8.6784 (1.9); 8.6723 (2.9); 8.6528 (3.2); 8.6467 (2.2); 8.3970 (2.2); 8.3913 (2.3); 8.1309 (1.0); 8.1253 (1.0); 8.1088 (1.2); 8.1032 (1.1); 8.0701 (2.6); 8.0657 (1.0); 8.0536 (1.0); 8.0490 (3.3); 7.8023 (3.0); 7.7978 (1.0); 7.7857 (0.9); 7.7812 (2.6); 7.4212 (1.8); 7.3987 (1.7); 5.3203 (0.6); 5.3035 (0.9); 5.2866 (0.6); 3.9712 (10.7); 3.3217 (16.0); 2.5245 (0.9); 2.5198 (1.4); 2.5111 (19.6); 2.5066 (41.9); 2.5020 (57.9); 2.4975 (40.7); 2.4930 (18.7); 1.4643 (3.4); 1.4471 (3.4); 0.0080 (1.4); -0.0002 (41.9); -0.0085 (1.4) I.1-100: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6925 (2.8); 8.6864 (3.5); 8.6278 (2.8); 8.6217 (2.4); 8.2879 (3.2); 8.2832 (1.7); 8.2792 (3.7); 8.2781 (3.7); 8.2754 (3.6); 8.2733 (3.9); 8.2666 (3.8); 8.2219 (1.9); 8.2176 (2.8); 8.2134 (1.5); 7.7815 (3.4); 7.7768 (1.1); 7.7649 (1.0); 7.7603 (3.2); 7.6088 (0.8); 7.5893 (0.8); 7.2606 (52.4); 5.7253 (0.6); 5.7066 (0.8); 5.6891 (0.6); 5.3002 (8.3); 3.1312 (1.7); 3.1126 (16.0); 1.4941 (4.6); 1.4773 (4.6); 0.0079 (1.7); -0.0002 (69.8); -0.0085 (2.1) I.1-101: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6581 (8.7); 8.6521 (11.8); 8.6138 (9.3); 8.6077 (7.4); 8.2679 (10.2); 8.2631 (3.5); 8.2514 (3.5); 8.2466 (11.9); 8.2132 (0.6); 8.1942 (3.5); 8.1896 (6.1); 8.1849 (3.8); 8.0330 (6.8); 8.0280 (6.7); 8.0268 (6.8); 7.9172 (2.3); 7.9147 (2.7); 7.9115 (2.4); 7.9091 (2.6); 7.8969 (2.7); 7.8944 (2.9); 7.8913 (2.7); 7.8888 (2.8); 7.8793 (0.5); 7.7899 (11.3); 7.7851 (3.5); 7.7734 (3.4); 7.7686 (11.2); 7.7643 (9.7); 7.7601 (9.1); 7.7451 (3.3); 7.7412 (3.7); 7.7385 (2.9); 7.5707 (5.2); 7.5510 (8.0); 7.5310 (3.1); 7.5187 (1.6); 7.2914 (0.6); 7.2602 (283.2); 7.2330 (0.6); 6.9966 (1.5); 6.5143 (5.7); 6.5097 (6.1); 6.5081 (6.3); 6.5035 (5.6); 5.8074 (0.6); 5.7909 (2.0); 5.7715 (2.3); 5.7542 (2.1); 5.7378 (0.6); 5.2999 (13.2); 3.9734 (2.4); 3.3186 (2.4); 1.5004 (15.9); 1.4837 (16.0); 1.4346 (1.2); 1.4176 (1.0); 1.3327 (0.6); 1.2843 (0.9); 1.2545 (1.4); 1.2464 (0.9); 0.1456 (1.0); 0.0691 (0.6); 0.0309 (0.9); 0.0079 (9.4); -0.0002 (372.8); -0.0085 (10.6); -0.0275 (0.6); -0.1494 (1.2) I.1-115: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1924 (0.5); 9.1757 (0.5); 8.9786 (6.1); 8.6942 (1.2); 8.6881 (1.9); 8.6677 (2.2); 8.6616 (1.5); 8.0664 (1.8); 8.0617 (0.6); 8.0500 (0.6); 8.0451 (2.1); 7.7914 (2.0); 7.7866 (0.6); 7.7749 (0.6); 7.7701 (1.7); 5.3276 (0.5); 4.0378 (0.5); 4.0201 (0.5); 3.3189 (16.0); 2.6701 (0.5); 2.6517 (6.1); 2.5407 (1.2); 2.5239 (1.6); 2.5192 (2.2); 2.5105 (26.9); 2.5059 (58.3); 2.5013 (81.6); 2.4967 (55.7); 2.4921 (24.0); 1.9887 (2.5); 1.9085 (1.0); 1.4819 (2.1); 1.4647 (2.0); 1.3551 (0.7); 1.1923 (0.8); 1.1745 (1.6); 1.1567 (0.8); 0.0080 (1.3); 0.0040 (0.6); -0.0002 (43.9); -0.0085 (1.1) I.1-116: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6693 (0.8); 8.6631 (1.3); 8.6455 (1.5); 8.6394 (1.0); 8.0707 (1.1); 8.0494 (1.4); 7.8027 (1.2); 7.7815 (1.1); 7.5877 (0.8); 7.5644 (0.8); 3.3182 (16.0); 2.5404 (1.2); 2.5342 (0.5); 2.5298 (0.6); 2.5236 (1.6); 2.5190 (2.1); 2.5102 (26.6); 2.5057 (57.6); 2.5010 (80.3); 2.4964 (54.6); 2.4919 (23.5); 2.2608 (1.5); 2.2573 (1.5); 1.9885 (1.8); 1.4476 (1.4); 1.4303 (1.4); 1.1922 (0.5); 1.1744 (1.1); 1.1566 (0.5); 0.0080 (1.1); -0.0002 (42.1); -0.0085 (1.1) BCS241005-Abroad STR 134 I.1-117: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9503 (0.6); 8.9308 (0.7); 8.7531 (1.6); 8.7470 (2.1); 8.7145 (2.7); 8.7084 (2.1); 8.4724 (1.6); 8.4716 (1.5); 8.4582 (1.6); 8.4574 (1.6); 8.1090 (2.2); 8.1043 (0.7); 8.0926 (0.7); 8.0878 (2.5); 7.7788 (2.3); 7.7739 (0.7); 7.7622 (0.7); 7.7575 (2.1); 7.4826 (1.5); 7.4767 (1.5); 7.1740 (1.2); 7.1673 (1.1); 7.1598 (1.1); 7.1531 (1.1); 5.3719 (0.5); 3.8767 (9.6); 3.3187 (16.0); 2.6701 (0.6); 2.5407 (1.4); 2.5240 (2.0); 2.5193 (2.5); 2.5105 (32.4); 2.5059 (70.5); 2.5014 (98.4); 2.4968 (67.4); 2.4922 (29.0); 2.3284 (0.6); 1.9887 (1.5); 1.4323 (2.7); 1.4155 (2.7); 1.3551 (0.8); 1.1746 (1.0); 0.0080 (1.4); -0.0002 (51.5); -0.0085 (1.4) I.1-118: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9637 (2.1); 8.9604 (2.0); 8.9216 (0.8); 8.9027 (0.8); 8.7376 (1.9); 8.7314 (2.7); 8.7068 (3.3); 8.7007 (2.4); 8.6204 (1.7); 8.6193 (1.8); 8.6169 (1.8); 8.6157 (1.6); 8.0933 (2.7); 8.0886 (0.8); 8.0768 (0.9); 8.0720 (3.2); 7.7747 (2.9); 7.7699 (0.9); 7.7582 (0.8); 7.7535 (2.6); 5.4029 (0.6); 5.3851 (0.7); 5.3672 (0.6); 3.3189 (16.0); 2.6703 (0.6); 2.5832 (7.9); 2.5409 (1.3); 2.5241 (1.7); 2.5194 (2.4); 2.5106 (33.8); 2.5061 (74.3); 2.5015 (103.9); 2.4969 (71.3); 2.4923 (31.1); 2.3286 (0.6); 1.9888 (1.9); 1.9087 (0.6); 1.4435 (3.4); 1.4266 (3.4); 1.3551 (1.0); 1.1924 (0.6); 1.1746 (1.2); 1.1568 (0.6); 0.0081 (1.5); -0.0002 (53.6); -0.0085 (1.4) I.1-119: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5370 (0.8); 8.5270 (0.8); 8.2713 (0.8); 8.2499 (0.9); 8.2090 (0.7); 8.1797 (0.6); 8.1698 (0.5); 7.7159 (0.8); 7.6945 (0.8); 7.2601 (45.7); 3.9737 (4.2); 1.7005 (1.4); 1.6829 (1.4); 1.5368 (16.0); 0.0080 (1.7); -0.0002 (59.9); -0.0085 (1.6) I.1-120: 1H-NMR (400.6 MHz, CDCl3): δ= 8.4614 (2.3); 8.4512 (2.5); 8.2811 (0.7); 8.2611 (0.8); 8.2294 (2.8); 8.1989 (3.1); 8.1888 (2.9); 8.0225 (1.3); 7.3022 (0.5); 7.2826 (0.5); 7.2617 (10.7); 5.2998 (1.3); 5.1883 (0.6); 5.1710 (0.7); 5.1692 (0.7); 5.1520 (0.6); 3.9755 (16.0); 2.1276 (1.6); 1.4328 (0.8); 1.4186 (1.2); 1.4140 (4.8); 1.3970 (4.7); 1.3334 (0.8); 1.2846 (1.2); 1.2553 (2.3); -0.0002 (14.2) I.1-121: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3113 (1.0); 9.2951 (1.1); 8.6865 (2.4); 8.6804 (3.7); 8.6623 (4.3); 8.6563 (2.9); 8.4201 (2.4); 8.4152 (2.4); 8.0682 (3.4); 8.0636 (1.1); 8.0518 (1.2); 8.0470 (4.1); 8.0399 (0.9); 8.0348 (0.7); 8.0192 (2.2); 8.0141 (2.3); 8.0012 (3.6); 7.9809 (1.1); 7.7949 (3.8); 7.7902 (1.1); 7.7784 (1.0); 7.7737 (3.2); 5.7568 (3.2); 5.3359 (0.7); 5.3188 (1.0); 5.3022 (0.7); 3.8950 (0.6); 3.3812 (16.0); 3.3489 (5.0); 3.1679 (1.8); 2.6746 (0.9); 2.6700 (1.2); 2.6654 (0.9); 2.5405 (2.9); 2.5345 (0.7); 2.5306 (0.6); 2.5237 (3.3); 2.5191 (4.8); 2.5103 (69.4); 2.5057 (150.7); 2.5011 (209.8); 2.4965 (144.1); 2.4920 (62.6); 2.3328 (0.9); 2.3282 (1.2); 2.3235 (0.8); 1.4744 (4.0); 1.4571 (3.9); 1.0551 (0.8); 0.0080 (3.5); -0.0002 (116.8); -0.0059 (0.7); -0.0085 (3.0) BCS241005-Abroad STR 135 I.1-122: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6666 (8.5); 8.6606 (11.0); 8.6163 (8.6); 8.6102 (6.9); 8.5957 (0.6); 8.2725 (10.0); 8.2678 (3.2); 8.2560 (3.3); 8.2512 (11.3); 8.2185 (0.7); 8.1373 (3.4); 8.1325 (5.5); 8.1278 (3.8); 8.0270 (13.0); 8.0255 (12.8); 7.9930 (0.7); 7.8602 (2.2); 7.8578 (2.6); 7.8545 (2.2); 7.8521 (2.4); 7.8400 (2.7); 7.8375 (2.9); 7.8343 (2.8); 7.8319 (2.7); 7.7903 (10.7); 7.7856 (3.5); 7.7738 (6.0); 7.7691 (11.3); 7.7573 (3.1); 7.7533 (3.6); 7.7506 (3.2); 7.6734 (11.3); 7.6721 (11.1); 7.5763 (3.9); 7.5563 (7.7); 7.5369 (4.4); 7.5187 (2.3); 7.2888 (1.1); 7.2685 (1.4); 7.2602 (409.9); 7.2372 (1.2); 7.2299 (0.7); 6.9966 (2.2); 5.7980 (0.6); 5.7813 (1.8); 5.7622 (2.2); 5.7448 (1.8); 5.7285 (0.6); 5.3001 (16.0); 3.9742 (2.7); 2.7788 (12.6); 1.4955 (15.3); 1.4788 (15.3); 1.4449 (1.4); 1.4281 (1.3); 1.2554 (2.0); 1.2464 (1.4); 0.1458 (1.3); 0.0690 (1.8); 0.0284 (1.3); 0.0111 (1.3); 0.0080 (12.8); -0.0002 (440.4); -0.0059 (5.4); - 0.0085 (12.0); -0.0233 (1.0); -0.0304 (0.8); -0.1494 (1.5) I.1-123: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6408 (2.6); 8.6347 (3.3); 8.5941 (2.9); 8.5881 (2.2); 8.2374 (3.2); 8.2329 (1.1); 8.2209 (1.2); 8.2164 (3.7); 8.0851 (1.3); 8.0806 (1.9); 8.0758 (1.2); 7.9854 (4.0); 7.8353 (0.8); 7.8319 (0.8); 7.8296 (0.8); 7.8149 (1.0); 7.8118 (0.9); 7.7653 (3.6); 7.7607 (1.2); 7.7441 (4.2); 7.7398 (1.3); 7.7232 (1.2); 7.6689 (3.6); 7.5633 (1.3); 7.5435 (2.1); 7.5237 (1.0); 7.4012 (0.7); 7.3811 (0.7); 7.2604 (59.8); 5.7143 (0.7); 5.6963 (0.8); 5.6781 (0.7); 3.9741 (16.0); 2.9217 (1.7); 2.7757 (7.8); 2.0077 (1.6); 1.5524 (6.0); 1.4368 (5.5); 1.4200 (5.5); 0.0691 (0.7); 0.0079 (2.5); -0.0002 (73.8); - 0.0084 (2.2) I.1-124: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6395 (0.8); 8.6334 (1.0); 8.5937 (0.8); 8.5876 (0.6); 8.2375 (1.0); 8.2160 (1.1); 8.0166 (1.1); 8.0151 (1.2); 7.7647 (1.0); 7.7479 (0.5); 7.7433 (1.2); 7.7007 (1.0); 7.6995 (1.0); 7.5453 (0.6); 7.2602 (51.7); 3.9741 (5.0); 2.7763 (3.7); 1.5421 (16.0); 1.4358 (1.5); 1.4191 (1.5); 0.0079 (1.5); -0.0002 (57.6); -0.0061 (0.5); -0.0085 (1.6) I.1-125: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8190 (0.9); 8.8017 (0.9); 8.7165 (2.3); 8.7105 (3.0); 8.6738 (3.7); 8.6677 (2.9); 8.1219 (3.2); 8.1171 (0.9); 8.1053 (1.1); 8.1005 (3.6); 7.8300 (0.6); 7.8258 (3.5); 7.8209 (1.0); 7.8092 (1.0); 7.8044 (3.0); 7.0621 (6.2); 6.7894 (6.2); 6.0953 (8.5); 5.7569 (5.5); 5.2485 (0.6); 5.2314 (1.0); 5.2142 (0.6); 3.9078 (13.4); 3.3192 (16.0); 2.5407 (0.7); 2.5239 (1.0); 2.5192 (1.4); 2.5105 (17.6); 2.5059 (38.2); 2.5013 (53.1); 2.4967 (36.2); 2.4922 (15.6); 1.9887 (1.1); 1.4195 (3.7); 1.4025 (3.7); 1.1745 (0.7); 0.0080 (1.2); -0.0002 (42.6); -0.0085 (1.1) I.1-126:1H-NMR (400.6 MHz, CDCl3): δ= 8.6638 (2.4); 8.6577 (2.9); 8.5972 (2.3); 8.5911 (1.9); 8.2724 (2.1); 8.2520 (2.4); 8.2382 (2.9); 8.2334 (0.9); 8.2217 (1.0); 8.2168 (3.2); 8.2048 (2.3); 8.2007 (2.3); 7.9028 (1.4); 7.8986 (1.3); 7.8824 (1.2); 7.8782 (1.2); 7.7391 (3.1); 7.7343 (0.9); 7.7226 (0.9); 7.7177 (2.8); 7.4600 (0.5); 7.4405 (0.5); 7.2628 (20.0); 5.6825 (0.6); 5.6655 (0.6); 5.6464 (0.6); 3.9772 (14.8); 3.3012 (16.0); 2.9589 (1.6); 2.8861 (1.4); 2.8847 (1.3); 2.1305 (0.6); 1.4279 (4.4); 1.4219 (0.6); 1.4112 (4.4); -0.0002 (13.4) BCS241005-Abroad STR 136 I.1-127: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6566 (6.0); 8.6505 (8.4); 8.6111 (6.8); 8.6051 (5.0); 8.2720 (7.9); 8.2506 (8.9); 8.1250 (4.0); 8.0705 (9.2); 7.8567 (1.8); 7.8364 (2.2); 7.7925 (8.3); 7.7711 (9.2); 7.7669 (3.6); 7.7448 (11.1); 7.5737 (3.2); 7.5536 (4.5); 7.5339 (2.5); 7.5187 (4.8); 7.4703 (1.4); 7.2603 (837.8); 7.2462 (1.2); 7.2297 (2.5); 6.9966 (4.5); 5.7606 (1.4); 5.7415 (1.8); 5.7248 (1.5); 1.5478 (16.0); 1.4782 (12.2); 1.4614 (11.6); 1.2559 (2.8); 0.1456 (2.9); 0.0328 (1.3); 0.0080 (24.5); -0.0002 (903.2); - 0.0085 (24.5); -0.0309 (2.4); -0.1496 (2.9) I.1-128: 1H-NMR (400.6 MHz, CDCl3): δ= 8.8117 (1.6); 8.8105 (1.7); 8.8056 (1.7); 8.8043 (1.6); 8.6565 (2.6); 8.6504 (3.1); 8.5855 (2.6); 8.5795 (2.3); 8.2381 (0.5); 8.2339 (3.2); 8.2292 (1.1); 8.2174 (1.1); 8.2127 (3.5); 8.2086 (0.6); 8.1072 (1.4); 8.1010 (1.4); 8.0865 (1.5); 8.0802 (1.5); 7.7442 (0.6); 7.7401 (3.5); 7.7354 (1.1); 7.7235 (1.1); 7.7188 (3.2); 7.7148 (0.6); 7.4297 (2.4); 7.4283 (2.4); 7.4090 (2.3); 7.4076 (2.2); 7.2633 (8.4); 5.6937 (0.7); 5.6749 (0.8); 5.6576 (0.7); 3.9739 (16.0); 2.0457 (0.6); 1.4209 (5.4); 1.4041 (5.4); -0.0002 (9.0) I.1-129: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7096 (1.0); 8.7035 (1.3); 8.6705 (1.6); 8.6644 (1.2); 8.0978 (1.3); 8.0766 (1.6); 7.7956 (1.4); 7.7743 (1.3); 7.0636 (2.7); 6.7946 (2.8); 6.0952 (3.4); 3.3197 (16.0); 2.5405 (0.7); 2.5237 (0.8); 2.5191 (1.1); 2.5103 (16.1); 2.5058 (35.0); 2.5012 (48.8); 2.4966 (33.5); 2.4920 (14.6); 1.9886 (1.8); 1.4187 (1.6); 1.4017 (1.6); 1.1922 (0.5); 1.1744 (1.1); 1.1566 (0.5); 0.0080 (0.9); -0.0002 (29.8); -0.0085 (0.8) I.1-133: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6384 (0.7); 8.6324 (0.9); 8.5926 (0.8); 8.5866 (0.7); 8.2373 (1.0); 8.2164 (1.0); 8.0892 (0.6); 8.0423 (1.3); 7.7648 (1.1); 7.7432 (2.0); 7.5443 (0.6); 7.2605 (31.8); 3.9742 (4.5); 1.5468 (16.0); 1.4355 (1.6); 1.4187 (1.6); 0.0079 (1.0); -0.0002 (30.4); -0.0085 (1.0) I.1-134:1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8376 (1.0); 8.8362 (1.0); 8.6885 (0.5); 8.6824 (0.8); 8.6601 (0.9); 8.6540 (0.7); 8.0853 (0.7); 8.0641 (0.9); 7.9162 (1.0); 7.9149 (0.9); 7.8279 (0.8); 7.8067 (0.7); 3.3190 (16.0); 2.5406 (0.7); 2.5238 (0.7); 2.5191 (1.0); 2.5104 (17.2); 2.5058 (37.9); 2.5012 (53.2); 2.4966 (36.6); 2.4920 (16.1); 1.4869 (0.8); 1.4697 (0.8); 0.0080 (1.1); -0.0002 (38.0); -0.0085 (1.1) I.1-135: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6641 (2.6); 8.6580 (3.2); 8.6045 (2.4); 8.5984 (2.0); 8.2412 (3.1); 8.2364 (1.0); 8.2247 (1.1); 8.2198 (3.4); 8.1986 (1.2); 8.1949 (2.4); 8.1912 (1.3); 7.9854 (1.2); 7.8880 (1.2); 7.7395 (3.3); 7.7347 (1.0); 7.7229 (1.0); 7.7181 (3.0); 7.5188 (0.8); 7.4482 (0.5); 7.4296 (0.6); 7.2603 (139.1); 6.9967 (0.8); 5.6946 (0.6); 5.6774 (0.7); 5.6587 (0.5); 3.9772 (15.9); 3.2139 (0.9); 3.1952 (2.9); 3.1767 (3.1); 3.1581 (0.9); 2.0455 (0.7); 1.5438 (16.0); 1.4400 (4.7); 1.4233 (4.6); 1.3473 (3.3); 1.3288 (7.3); 1.3101 (3.2); 1.2597 (0.6); 0.1458 (0.6); 0.0120 (1.0); 0.0080 (6.6); 0.0064 (2.5); 0.0048 (4.0); -0.0002 (218.7); -0.0059 (1.3); -0.0067 (1.6); -0.0085 (6.0); -0.0260 (0.5); -0.1492 (0.6) BCS241005-Abroad STR 137 I.1-136: 1H NMR (600.3 MHz, MeOD): δ= 8.6713 (4.6); 8.6672 (5.3); 8.6074 (5.5); 8.6032 (5.0); 8.3861 (8.3); 8.1921 (6.4); 8.1783 (7.1); 8.1342 (3.6); 7.8141 (6.9); 7.8003 (6.4); 7.3032 (4.8); 7.2928 (5.1); 7.2892 (5.6); 7.2788 (5.2); 7.1670 (6.6); 7.1626 (7.0); 7.1525 (6.7); 7.1480 (7.0); 6.9832 (3.8); 6.9787 (3.7); 6.9691 (7.1); 6.9647 (6.9); 6.9551 (3.5); 6.9507 (3.4); 5.5265 (0.8); 5.5150 (2.5); 5.5034 (2.6); 5.4919 (0.8); 4.8503 (7.2); 3.3666 (0.9); 3.3332 (4.5); 3.3305 (8.9); 3.3278 (12.8); 3.3251 (9.1); 3.3224 (4.7); 2.3608 (0.3); 2.3360 (50.0); 2.3210 (0.4); 2.0058 (0.6); 1.5554 (10.7); 1.5438 (10.8) I.1-137: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7698 (0.5); 8.7588 (1.6); 8.7526 (2.4); 8.7131 (2.4); 8.7070 (1.9); 8.1742 (0.8); 8.1555 (0.9); 8.1114 (2.1); 8.1066 (0.7); 8.0949 (0.7); 8.0900 (2.5); 7.8961 (0.6); 7.8918 (0.6); 7.8733 (0.5); 7.7963 (2.4); 7.7914 (0.7); 7.7798 (0.7); 7.7750 (2.1); 7.4453 (0.5); 7.4411 (0.5); 7.4247 (0.5); 7.4206 (0.5); 5.7576 (1.3); 5.3544 (0.6); 3.9081 (9.3); 3.3201 (16.0); 2.5415 (0.6); 2.5248 (0.6); 2.5201 (0.9); 2.5113 (12.8); 2.5068 (27.7); 2.5022 (38.6); 2.4976 (26.4); 2.4930 (11.5); 1.4415 (2.7); 1.4246 (2.7); 0.0080 (0.5); -0.0002 (19.4); -0.0085 (0.5) I.1-139:1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7716 (1.5); 8.7549 (5.5); 8.7489 (6.4); 8.7125 (6.8); 8.7064 (5.4); 8.1974 (1.0); 8.1772 (2.2); 8.1585 (2.5); 8.1382 (1.1); 8.0998 (0.8); 8.0955 (5.9); 8.0909 (1.8); 8.0791 (2.0); 8.0743 (6.8); 8.0702 (0.9); 7.9054 (1.6); 7.9010 (1.6); 7.8884 (1.4); 7.8869 (1.4); 7.8825 (1.5); 7.7751 (1.0); 7.7710 (6.5); 7.7662 (1.9); 7.7545 (1.8); 7.7498 (5.7); 7.7456 (0.8); 7.4475 (1.6); 7.4432 (1.6); 7.4269 (1.5); 7.4228 (1.5); 5.3826 (1.2); 5.3648 (1.6); 5.3470 (1.2); 4.0385 (1.2); 4.0207 (1.2); 3.3222 (16.0); 2.6715 (0.6); 2.5420 (1.6); 2.5349 (0.6); 2.5300 (0.8); 2.5253 (1.9); 2.5206 (2.4); 2.5118 (31.0); 2.5073 (67.2); 2.5027 (93.5); 2.4981 (63.9); 2.4935 (27.7); 2.3298 (0.5); 1.9895 (5.6); 1.9099 (2.3); 1.4413 (7.6); 1.4244 (7.6); 1.3556 (0.8); 1.1929 (1.6); 1.1813 (0.6); 1.1751 (3.3); 1.1573 (1.6); 0.0080 (0.9); -0.0002 (31.2); -0.0086 (0.8) I.1-140:1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1108 (3.2); 9.1723 (4.3); 9.1559 (4.5); 8.7658 (7.7); 8.7603 (7.7); 8.6901 (7.7); 8.6840 (11.8); 8.6655 (12.4); 8.6594 (8.3); 8.2067 (4.8); 8.2005 (4.8); 8.1859 (5.3); 8.1796 (5.2); 8.0737 (11.2); 8.0529 (13.5); 7.7978 (13.0); 7.7771 (11.3); 7.6103 (7.7); 7.5894 (7.3); 5.3568 (0.6); 5.3398 (2.7); 5.3229 (4.2); 5.3059 (2.8); 5.2891 (0.6); 3.4094 (0.6); 3.3919 (1.8); 3.3745 (1.9); 3.3570 (0.9); 3.3290 (11.5); 2.6733 (0.5); 2.5440 (1.0); 2.5132 (33.8); 2.5091 (66.7); 2.5047 (88.6); 2.5003 (64.3); 2.3317 (0.5); 1.9904 (0.8); 1.4748 (16.0); 1.4577 (16.0); 1.1088 (1.8); 1.0913 (3.6); 1.0739 (1.8); -0.0002 (15.3); -0.0084 (0.7) BCS241005-Abroad STR 138 I.1-142: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6502 (2.6); 8.6441 (3.2); 8.6030 (2.7); 8.5969 (2.1); 8.2307 (3.2); 8.2259 (1.0); 8.2142 (1.1); 8.2094 (3.4); 8.2051 (0.5); 7.8609 (5.9); 7.8566 (6.7); 7.8003 (1.8); 7.7960 (2.9); 7.7916 (1.4); 7.7398 (0.6); 7.7356 (3.4); 7.7308 (1.0); 7.7191 (1.0); 7.7143 (3.0); 7.2715 (0.6); 7.2619 (10.0); 5.6539 (0.6); 5.6370 (0.7); 5.6346 (0.7); 5.6176 (0.6); 3.9729 (16.0); 1.4103 (5.1); 1.3936 (5.1); -0.0002 (12.4) I.1-143: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1302 (1.1); 9.1139 (1.1); 8.6857 (2.1); 8.6796 (3.1); 8.6602 (3.4); 8.6542 (2.3); 8.0717 (3.0); 8.0507 (3.6); 8.0025 (1.2); 7.9982 (2.5); 7.9939 (2.2); 7.9777 (6.8); 7.9734 (4.7); 7.7849 (3.4); 7.7639 (3.0); 5.3081 (0.7); 5.2913 (1.0); 5.2742 (0.7); 3.3279 (16.0); 2.5263 (0.7); 2.5129 (12.7); 2.5085 (25.9); 2.5040 (34.8); 2.4995 (24.7); 2.4951 (11.5); 1.4650 (3.9); 1.4478 (3.9); 0.0079 (0.6); -0.0002 (15.1); -0.0085 (0.6) I.1-144: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6470 (2.5); 8.6409 (3.1); 8.5911 (2.5); 8.5850 (2.0); 8.2299 (3.0); 8.2251 (1.0); 8.2134 (1.0); 8.2086 (3.4); 7.9070 (2.3); 7.9019 (2.4); 7.7467 (0.5); 7.7425 (3.2); 7.7377 (1.0); 7.7260 (1.0); 7.7212 (3.0); 7.6513 (1.2); 7.6461 (1.1); 7.6305 (1.6); 7.6253 (1.6); 7.5302 (2.8); 7.5094 (2.0); 7.2619 (14.3); 5.6709 (0.6); 5.6539 (0.7); 5.6515 (0.7); 5.6345 (0.6); 3.9721 (16.0); 1.4100 (5.0); 1.3933 (5.0); -0.0002 (13.0) I.1-145: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6490 (2.6); 8.6429 (3.2); 8.5917 (2.6); 8.5856 (2.1); 8.2302 (3.1); 8.2254 (1.0); 8.2137 (1.1); 8.2089 (3.4); 8.2047 (0.5); 7.9083 (2.5); 7.9031 (2.5); 7.7482 (0.6); 7.7439 (3.3); 7.7392 (1.0); 7.7274 (1.0); 7.7227 (3.0); 7.6523 (1.2); 7.6471 (1.2); 7.6315 (1.7); 7.6263 (1.6); 7.5296 (2.9); 7.5088 (2.1); 7.3450 (0.5); 7.3256 (0.5); 7.2619 (13.4); 5.6712 (0.7); 5.6542 (0.8); 5.6520 (0.7); 5.6349 (0.6); 3.9720 (16.0); 1.4119 (5.2); 1.3951 (5.2); -0.0002 (13.0) I.1-146: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6437 (2.5); 8.6376 (3.2); 8.5897 (2.6); 8.5836 (2.1); 8.2289 (3.1); 8.2242 (1.0); 8.2124 (1.0); 8.2076 (3.4); 8.2034 (0.5); 8.0563 (2.4); 8.0512 (2.5); 7.7454 (0.5); 7.7412 (3.3); 7.7364 (1.1); 7.7246 (1.0); 7.7199 (3.1); 7.7031 (2.0); 7.6824 (3.0); 7.6007 (1.7); 7.5954 (1.6); 7.5799 (1.1); 7.5747 (1.1); 7.3105 (0.5); 7.2906 (0.5); 7.2626 (16.1); 5.6650 (0.6); 5.6481 (0.7); 5.6457 (0.7); 5.6288 (0.6); 3.9717 (16.0); 1.5987 (2.0); 1.4079 (5.1); 1.3911 (5.0); -0.0002 (9.3) I.1-147: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6332 (1.7); 8.6271 (2.1); 8.5811 (1.7); 8.5750 (1.3); 8.2276 (2.1); 8.2228 (0.7); 8.2063 (2.2); 7.8119 (2.0); 7.8072 (0.6); 7.7954 (0.7); 7.7905 (2.1); 7.7570 (2.2); 7.7522 (0.7); 7.7357 (2.0); 7.5186 (0.7); 7.3596 (2.2); 7.3381 (2.0); 7.2602 (128.8); 6.9966 (0.7); 5.3001 (0.9); 3.9706 (10.6); 1.8228 (0.6); 1.8097 (1.6); 1.8035 (1.7); 1.7912 (0.6); 1.5405 (16.0); 1.4784 (0.7); 1.4649 (1.7); 1.4587 (1.7); 1.4458 (0.5); 1.4109 (3.3); 1.3942 (3.4); 0.1459 (0.6); 0.0079 (4.9); -0.0002 (158.0); -0.0085 (4.2); -0.1494 (0.6) BCS241005-Abroad STR 139 I.1-148: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6353 (1.5); 8.6292 (1.9); 8.5913 (1.6); 8.5852 (1.2); 8.2324 (1.8); 8.2277 (0.6); 8.2159 (0.6); 8.2111 (2.0); 7.7610 (2.0); 7.7561 (0.6); 7.7444 (0.6); 7.7397 (1.8); 7.6915 (0.5); 7.6803 (0.6); 7.6755 (1.9); 7.6715 (2.0); 7.5394 (0.6); 7.5354 (0.8); 7.4601 (0.8); 7.4398 (0.9); 7.2606 (27.6); 3.9718 (9.4); 1.7833 (0.7); 1.7708 (1.5); 1.7644 (1.6); 1.7522 (0.8); 1.5506 (16.0); 1.4704 (1.5); 1.4635 (1.3); 1.4200 (3.0); 1.4033 (3.0); 0.0079 (1.0); -0.0002 (33.9); -0.0085 (0.9) I.1-149: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6439 (2.6); 8.6378 (3.2); 8.5901 (2.6); 8.5840 (2.1); 8.2333 (0.5); 8.2291 (3.2); 8.2244 (1.0); 8.2126 (1.1); 8.2078 (3.3); 8.2036 (0.5); 8.0564 (2.6); 8.0513 (2.6); 7.7450 (0.6); 7.7408 (3.5); 7.7360 (1.0); 7.7242 (1.1); 7.7195 (3.0); 7.7040 (2.1); 7.6833 (3.0); 7.6008 (1.7); 7.5955 (1.6); 7.5800 (1.2); 7.5748 (1.2); 7.3073 (0.5); 7.2875 (0.5); 7.2620 (12.4); 5.6653 (0.6); 5.6482 (0.8); 5.6460 (0.7); 5.6289 (0.6); 3.9719 (16.0); 1.5827 (5.1); 1.4078 (5.2); 1.3911 (5.1); -0.0002 (13.2) I.1-150: 1H-NMR (400.6 MHz, CDCl3): δ= 8.9334 (2.4); 8.9286 (2.4); 8.7990 (2.1); 8.7934 (2.1); 8.6582 (2.7); 8.6522 (3.2); 8.5961 (2.7); 8.5901 (2.2); 8.2795 (1.8); 8.2744 (2.9); 8.2691 (1.7); 8.2397 (0.5); 8.2354 (3.3); 8.2308 (1.0); 8.2190 (1.1); 8.2143 (3.4); 7.7440 (0.6); 7.7399 (3.9); 7.7350 (1.1); 7.7233 (1.2); 7.7185 (3.4); 7.2692 (3.6); 5.6899 (0.7); 5.6727 (0.8); 5.6538 (0.7); 3.9753 (16.0); 2.0455 (0.6); 1.4239 (5.8); 1.4072 (5.8); -0.0002 (3.2) I.1-151: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1981 (1.6); 9.1827 (1.6); 8.8774 (3.0); 8.8269 (2.7); 8.8229 (2.6); 8.6880 (3.2); 8.6679 (3.2); 8.3843 (2.8); 8.0723 (3.4); 8.0522 (3.8); 7.7909 (3.8); 7.7710 (3.4); 5.3374 (1.0); 5.3208 (1.4); 5.3039 (1.0); 3.3297 (16.0); 2.5039 (49.6); 1.4791 (5.2); 1.4623 (5.2); - 0.0002 (11.1) I.1-152:1H-NMR (400.6 MHz, CDCl3): δ= 8.6577 (2.5); 8.6516 (3.1); 8.6063 (2.7); 8.6002 (2.2); 8.2356 (3.2); 8.2309 (1.0); 8.2191 (1.1); 8.2144 (3.5); 8.2102 (0.5); 7.8582 (1.4); 7.8543 (2.6); 7.8504 (1.4); 7.7420 (0.6); 7.7377 (3.4); 7.7330 (1.1); 7.7212 (1.0); 7.7165 (3.2); 7.6103 (1.4); 7.5272 (1.3); 7.3365 (0.6); 7.3164 (0.6); 7.2621 (30.2); 5.6673 (0.7); 5.6483 (0.8); 5.6311 (0.7); 3.9752 (16.0); 1.5663 (14.7); 1.4171 (5.2); 1.4004 (5.2); 0.0079 (1.2); -0.0002 (39.8); -0.0084 (1.1) I.1-153: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6573 (2.3); 8.6512 (2.8); 8.6008 (2.4); 8.5947 (2.0); 8.2358 (2.9); 8.2312 (0.9); 8.2193 (1.0); 8.2146 (3.2); 7.7380 (3.1); 7.7333 (1.0); 7.7215 (1.0); 7.7168 (2.9); 7.4764 (1.9); 7.4711 (2.2); 7.4583 (0.7); 7.4527 (0.8); 7.4490 (0.5); 7.3458 (0.5); 7.2621 (30.2); 7.1244 (0.6); 7.1219 (0.6); 7.1028 (0.6); 5.6738 (0.6); 5.6567 (0.7); 5.6375 (0.6); 3.9756 (14.7); 1.5641 (16.0); 1.4136 (4.9); 1.3969 (4.9); 0.0080 (1.2); -0.0002 (40.0); -0.0085 (1.1) BCS241005-Abroad STR 140 I.1-154: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9652 (0.7); 8.9486 (0.7); 8.6760 (1.5); 8.6699 (2.5); 8.6535 (2.9); 8.6474 (1.9); 8.0766 (2.2); 8.0720 (0.7); 8.0602 (0.8); 8.0554 (2.6); 7.8169 (2.5); 7.8122 (0.7); 7.8004 (0.7); 7.7957 (2.1); 7.7582 (0.7); 7.7544 (0.5); 7.7427 (0.5); 7.7390 (0.8); 7.7355 (0.6); 7.6770 (0.8); 7.6729 (1.3); 7.6688 (0.7); 7.4930 (0.7); 7.4898 (0.8); 7.4882 (0.9); 7.4850 (0.6); 7.4588 (1.0); 7.4396 (1.3); 5.7568 (1.2); 5.3214 (0.7); 3.3268 (16.0); 2.5249 (0.6); 2.5202 (0.8); 2.5115 (11.6); 2.5070 (25.4); 2.5024 (35.3); 2.4978 (24.1); 2.4932 (10.5); 1.7842 (0.7); 1.7723 (1.6); 1.7649 (2.0); 1.7535 (0.9); 1.5672 (0.6); 1.5645 (0.5); 1.5541 (1.8); 1.5472 (1.8); 1.4665 (2.6); 1.4493 (2.6); 1.3557 (0.7); 0.0080 (0.6); -0.0002 (24.4); -0.0085 (0.6) I.1-155: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1896 (0.5); 9.1733 (0.6); 8.6877 (1.2); 8.6816 (2.0); 8.6634 (2.2); 8.6574 (1.5); 8.0870 (0.8); 8.0831 (1.4); 8.0792 (0.9); 8.0639 (1.8); 8.0594 (0.6); 8.0475 (0.6); 8.0428 (2.1); 7.8539 (0.8); 7.7825 (2.0); 7.7778 (0.6); 7.7660 (0.6); 7.7613 (1.7); 7.7437 (0.7); 7.7409 (0.8); 7.7382 (0.7); 5.3101 (0.6); 3.3208 (16.0); 2.5245 (0.8); 2.5198 (1.1); 2.5111 (17.8); 2.5065 (38.7); 2.5019 (53.8); 2.4974 (36.8); 2.4928 (16.1); 1.9890 (1.4); 1.4759 (2.1); 1.4587 (2.1); 1.1748 (0.8); 0.0080 (0.7); -0.0002 (24.1); -0.0085 (0.6) I.1-156: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1415 (2.1); 9.1251 (2.1); 8.6866 (4.7); 8.6805 (7.7); 8.6634 (8.6); 8.6574 (5.5); 8.0632 (6.8); 8.0586 (2.1); 8.0468 (2.4); 8.0421 (8.0); 8.0379 (1.1); 7.7846 (7.6); 7.7799 (2.3); 7.7681 (2.2); 7.7635 (6.5); 7.7420 (1.4); 7.7386 (1.6); 7.7363 (1.6); 7.7328 (1.4); 7.7188 (1.4); 7.7154 (1.7); 7.7130 (1.5); 7.7096 (1.4); 7.6409 (2.8); 7.5972 (1.4); 7.5769 (1.4); 5.3326 (1.4); 5.3157 (2.1); 5.2988 (1.4); 3.3228 (14.4); 2.6715 (0.7); 2.5420 (0.5); 2.5348 (0.6); 2.5302 (0.8); 2.5253 (2.2); 2.5206 (2.9); 2.5118 (38.3); 2.5073 (82.0); 2.5027 (113.2); 2.4981 (77.1); 2.4936 (33.3); 2.3298 (0.7); 2.0865 (16.0); 1.9890 (0.6); 1.9098 (0.9); 1.4785 (8.3); 1.4612 (8.3); 1.3559 (1.7); 1.1815 (0.7); 1.1412 (1.0); 0.0080 (1.5); -0.0002 (52.4); -0.0086 (1.4) I.1-157: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6670 (2.5); 8.6610 (3.1); 8.6110 (2.7); 8.6049 (2.2); 8.2491 (3.8); 8.2451 (5.0); 8.2402 (1.2); 8.2283 (1.1); 8.2236 (3.5); 8.2195 (0.6); 8.0189 (1.4); 7.7528 (0.6); 7.7486 (3.4); 7.7439 (1.1); 7.7321 (1.0); 7.7274 (3.1); 7.7232 (0.5); 7.4575 (0.6); 7.4376 (0.6); 7.2614 (15.5); 5.7124 (0.7); 5.6953 (0.8); 5.6763 (0.7); 3.9778 (16.0); 1.5744 (13.2); 1.4517 (5.3); 1.4350 (5.3); 0.0080 (0.6); -0.0002 (18.5); -0.0085 (0.5) I.1-158: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7064 (8.2); 8.7003 (9.8); 8.6340 (8.4); 8.6279 (7.4); 8.2961 (16.0); 8.2922 (14.2); 8.2802 (3.6); 8.2756 (10.6); 8.0246 (4.9); 7.7976 (10.2); 7.7931 (3.3); 7.7810 (3.2); 7.7765 (9.4); 7.7349 (2.4); 7.7156 (2.4); 7.5192 (0.5); 7.2607 (94.5); 5.7605 (2.0); 5.7432 (2.6); 5.7245 (2.0); 5.3001 (2.3); 1.5186 (14.6); 1.5018 (14.5); 0.0080 (3.3); -0.0002 (112.7); -0.0085 (3.3) BCS241005-Abroad STR 141 I.1-159: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6901 (0.7); 8.6840 (1.0); 8.6632 (1.2); 8.6571 (0.8); 8.0843 (1.0); 8.0629 (1.1); 7.8209 (1.1); 7.7995 (0.9); 7.5904 (0.7); 3.8957 (4.2); 3.3201 (16.0); 2.5195 (0.5); 2.5108 (8.5); 2.5062 (18.6); 2.5016 (26.1); 2.4970 (17.8); 2.4924 (7.8); 1.9888 (0.8); 1.8024 (0.7); 1.7948 (0.7); 1.6031 (0.7); 1.5959 (0.7); 1.4756 (1.1); 1.4584 (1.1); -0.0002 (14.9) I.1-160: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6481 (4.0); 8.6421 (5.4); 8.5983 (4.5); 8.5920 (3.9); 8.2529 (5.2); 8.2319 (5.8); 7.8298 (4.9); 7.8084 (5.7); 7.7802 (5.7); 7.7593 (5.1); 7.5187 (4.4); 7.3665 (5.9); 7.3451 (5.1); 7.2601 (783.9); 6.9965 (4.2); 5.7111 (1.7); 3.9675 (1.7); 3.6253 (3.2); 2.1111 (1.6); 1.8272 (1.7); 1.8136 (4.3); 1.8073 (4.1); 1.7952 (1.9); 1.5434 (16.0); 1.4830 (3.8); 1.4689 (5.5); 1.4628 (5.8); 1.4482 (10.3); 1.4314 (9.2); 1.2547 (2.5); 0.1459 (4.0); 0.0080 (29.8); -0.0002 (964.4); -0.0085 (27.7); - 0.1494 (3.7) I.1-161: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6759 (0.5); 8.6591 (0.6); 8.0471 (0.6); 7.7980 (0.5); 3.3202 (16.0); 2.5192 (0.7); 2.5104 (10.2); 2.5059 (22.2); 2.5013 (30.9); 2.4967 (21.1); 2.4921 (9.2); 1.9886 (1.4); 1.4726 (0.6); 1.4554 (0.6); 1.1745 (0.8); -0.0002 (15.0) I.1-163: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6867 (0.6); 8.6806 (1.0); 8.6645 (1.2); 8.6584 (0.8); 8.0612 (0.9); 8.0400 (1.1); 7.7926 (1.0); 7.7714 (0.9); 7.7588 (0.7); 3.3214 (16.0); 2.5410 (0.6); 2.5242 (0.7); 2.5195 (0.9); 2.5108 (12.8); 2.5062 (27.7); 2.5016 (38.4); 2.4970 (26.1); 2.4924 (11.3); 1.8301 (0.5); 1.8218 (0.7); 1.6410 (0.7); 1.6331 (0.5); 1.4859 (1.0); 1.4686 (1.0); -0.0002 (14.9) I.1-164: 1H-NMR (400.6 MHz, CDCl3): δ= 9.1222 (5.4); 8.6486 (2.5); 8.6425 (3.2); 8.6062 (2.7); 8.6001 (2.0); 8.5058 (1.8); 8.5025 (1.8); 8.2462 (0.5); 8.2419 (3.0); 8.2371 (1.0); 8.2254 (1.1); 8.2206 (3.4); 8.2162 (0.6); 8.1997 (1.6); 8.1785 (1.9); 7.9494 (1.5); 7.9450 (1.4); 7.9280 (1.2); 7.9236 (1.2); 7.7750 (3.2); 7.7702 (1.0); 7.7585 (1.0); 7.7537 (2.9); 7.4622 (0.5); 7.4428 (0.5); 7.2604 (71.7); 5.7483 (0.6); 5.7312 (0.7); 5.7117 (0.6); 4.1311 (1.1); 4.1132 (1.1); 3.9765 (16.0); 2.0455 (5.3); 1.5466 (4.6); 1.4482 (5.0); 1.4315 (4.9); 1.2774 (1.5); 1.2596 (3.1); 1.2418 (1.4); 0.0079 (2.6); -0.0002 (89.9); -0.0085 (2.4) I.1-165: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6991 (0.5); 8.6929 (0.8); 8.6702 (0.9); 8.6642 (0.6); 8.1603 (0.7); 8.0983 (0.5); 8.0733 (0.7); 8.0522 (0.9); 7.7937 (0.8); 7.7726 (0.7); 3.8986 (3.1); 3.3203 (16.0); 2.5108 (7.5); 2.5062 (16.2); 2.5017 (22.5); 2.4971 (15.5); 2.4925 (6.8); 1.4876 (0.9); 1.4704 (0.9); -0.0002 (9.6) BCS241005-Abroad STR 142 I.1-166: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.5830 (1.0); 9.5228 (16.0); 9.0118 (2.3); 8.9955 (2.4); 8.6832 (5.4); 8.6771 (8.2); 8.6576 (9.6); 8.6515 (6.5); 8.6150 (4.7); 8.6116 (4.6); 8.1563 (0.5); 8.1130 (4.1); 8.0917 (6.1); 8.0850 (7.5); 8.0804 (2.4); 8.0685 (2.7); 8.0638 (9.1); 7.9767 (4.1); 7.9723 (3.9); 7.9553 (3.1); 7.9509 (3.1); 7.8324 (8.4); 7.8276 (2.4); 7.8159 (2.4); 7.8112 (7.3); 5.3628 (1.5); 5.3460 (2.3); 5.3291 (1.5); 4.1290 (1.9); 3.5421 (2.4); 3.5153 (2.3); 3.5087 (0.7); 3.1676 (0.8); 2.6799 (0.9); 2.6753 (2.1); 2.6707 (2.9); 2.6661 (2.1); 2.5443 (0.9); 2.5412 (3.5); 2.5355 (1.9); 2.5309 (1.8); 2.5245 (7.1); 2.5198 (10.3); 2.5111 (166.8); 2.5065 (365.9); 2.5019 (511.8); 2.4973 (350.3); 2.4928 (153.8); 2.4792 (1.8); 2.4749 (1.3); 2.4705 (0.9); 2.4613 (0.6); 2.4520 (0.8); 2.3381 (0.9); 2.3336 (2.1); 2.3290 (2.9); 2.3243 (2.0); 2.3195 (0.8); 1.4863 (10.1); 1.4690 (9.6); 1.2585 (0.7); 1.2343 (1.5); 0.9565 (1.0); 0.9482 (1.0); 0.9422 (2.6); 0.9389 (2.0); 0.9244 (1.2); 0.1456 (0.8); 0.0375 (0.6); 0.0080 (7.2); -0.0002 (287.2); -0.0085 (8.0); -0.0243 (0.5); -0.0277 (0.6); -0.0315 (0.8); -0.1493 (0.8) I.1-167: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6499 (1.0); 8.6438 (1.2); 8.6210 (1.7); 8.5993 (1.0); 8.5932 (0.8); 8.2399 (1.2); 8.2185 (1.4); 8.1309 (1.8); 7.8117 (0.5); 7.8070 (0.8); 7.8031 (0.6); 7.7587 (1.3); 7.7374 (1.2); 7.7107 (0.5); 7.7061 (1.0); 7.7014 (0.6); 7.6578 (0.6); 7.6539 (0.9); 7.6499 (0.5); 7.2604 (55.7); 4.1310 (0.6); 4.1132 (0.6); 3.9747 (6.2); 2.5940 (6.2); 2.0455 (2.6); 1.5438 (16.0); 1.4378 (1.9); 1.4210 (1.9); 1.2775 (0.8); 1.2597 (1.6); 1.2418 (0.7); 0.0080 (2.2); -0.0002 (69.2); -0.0085 (2.1) I.1-168: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6401 (1.6); 8.6340 (2.0); 8.5948 (1.8); 8.5887 (1.4); 8.3668 (1.3); 8.2354 (2.1); 8.2308 (0.7); 8.2189 (0.8); 8.2143 (2.2); 7.8819 (2.0); 7.8719 (1.5); 7.8680 (1.4); 7.7697 (2.3); 7.7650 (0.7); 7.7531 (0.7); 7.7486 (1.9); 7.2605 (45.7); 5.7228 (0.5); 4.1311 (0.6); 4.1133 (0.6); 3.9739 (10.1); 2.8702 (9.9); 2.0455 (2.9); 1.5462 (16.0); 1.4313 (3.4); 1.4147 (3.4); 1.2775 (0.8); 1.2596 (1.7); 1.2418 (0.8); 0.0079 (1.7); -0.0002 (54.5); -0.0085 (1.6) I.1-170: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6424 (1.6); 8.6363 (2.4); 8.6126 (2.0); 8.6065 (1.4); 8.3385 (1.2); 8.2451 (2.2); 8.2405 (0.7); 8.2286 (0.8); 8.2240 (2.4); 7.9568 (0.6); 7.9387 (0.6); 7.9336 (0.6); 7.9182 (0.5); 7.8966 (1.6); 7.8854 (0.6); 7.8790 (1.4); 7.8747 (1.5); 7.8677 (0.7); 7.7975 (2.4); 7.7929 (0.8); 7.7810 (0.7); 7.7764 (2.2); 7.5773 (0.8); 7.5732 (0.7); 7.5656 (0.8); 7.5597 (1.6); 7.5536 (0.7); 7.5462 (0.6); 7.5422 (0.7); 7.2603 (40.6); 5.7564 (0.6); 3.9754 (10.8); 2.0455 (0.6); 1.5465 (16.0); 1.4671 (3.7); 1.4503 (3.7); 0.0079 (1.6); -0.0002 (48.5); -0.0085 (1.5) BCS241005-Abroad STR 143 I.1-171: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6493 (2.5); 8.6432 (3.3); 8.5987 (2.9); 8.5926 (2.4); 8.3672 (2.2); 8.3635 (2.3); 8.2374 (3.3); 8.2329 (1.2); 8.2209 (1.2); 8.2164 (3.7); 7.9438 (1.1); 7.9396 (1.0); 7.9228 (1.8); 7.9186 (1.8); 7.8667 (2.8); 7.8457 (1.6); 7.7644 (3.7); 7.7600 (1.2); 7.7479 (1.1); 7.7435 (3.3); 7.5233 (0.7); 7.5039 (0.7); 7.2609 (36.9); 5.7345 (0.7); 5.7156 (0.9); 5.6981 (0.7); 4.1311 (0.7); 4.1132 (0.7); 3.9753 (16.0); 2.0456 (3.2); 1.5543 (5.3); 1.4348 (5.7); 1.4182 (5.7); 1.2774 (1.0); 1.2596 (2.0); 1.2418 (0.9); 0.0079 (1.4); -0.0002 (43.0); -0.0084 (1.5) I.1-174:1H-NMR (400.6 MHz, CDCl3): δ= 8.6487 (2.5); 8.6439 (3.0); 8.5918 (3.0); 8.5862 (2.6); 8.2515 (3.8); 8.2315 (4.2); 7.9090 (2.7); 7.9049 (2.8); 7.7423 (4.1); 7.7222 (3.9); 7.6526 (1.3); 7.6492 (1.2); 7.6319 (1.7); 7.6280 (1.8); 7.5346 (2.9); 7.5134 (2.2); 7.3212 (1.1); 7.3010 (1.2); 7.2625 (21.6); 7.2609 (22.3); 5.6739 (1.0); 5.6562 (1.3); 5.6391 (1.0); 4.5541 (2.2); 4.5425 (3.0); 4.5302 (2.5); 3.8893 (2.4); 3.8766 (3.2); 3.8654 (2.4); 3.7414 (2.2); 3.7321 (3.2); 3.7190 (3.2); 3.6082 (3.1); 3.5953 (3.3); 3.5851 (2.3); 3.4064 (15.8); 3.4049 (16.0); 2.0459 (0.8); 1.5765 (2.5); 1.4082 (6.3); 1.3916 (6.3); 1.2597 (1.1); 1.2434 (0.5); 0.0015 (31.4); -0.0002 (32.4) I.1-175: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6577 (5.6); 8.6348 (5.7); 8.3754 (5.9); 8.2701 (6.2); 8.2496 (7.4); 7.9675 (2.5); 7.9478 (3.0); 7.9092 (6.6); 7.8973 (6.9); 7.8744 (4.2); 7.8106 (6.9); 7.7905 (7.0); 7.5817 (3.4); 7.5661 (5.0); 7.5492 (2.9); 7.2909 (1.6); 7.2600 (205.0); 7.2577 (186.6); 5.8333 (1.7); 5.8152 (2.6); 5.7961 (1.6); 3.4933 (4.3); 1.5225 (16.0); 1.5058 (14.9); 1.2525 (1.9); 0.1457 (1.8); 0.0289 (3.4); -0.0002 (304.3); -0.0025 (269.4); -0.1496 (1.7) I.1-176: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6578 (2.7); 8.6517 (3.2); 8.6158 (3.2); 8.6101 (2.6); 8.2539 (3.8); 8.2336 (4.1); 8.1452 (3.1); 7.8053 (1.3); 7.7806 (4.6); 7.7601 (3.8); 7.7270 (3.0); 7.7063 (2.0); 7.5897 (1.2); 7.5698 (1.4); 7.5197 (0.5); 7.2605 (94.6); 6.9981 (0.6); 5.7980 (0.9); 5.7793 (1.2); 5.7627 (1.0); 4.2388 (16.0); 3.4951 (0.6); 1.5791 (1.8); 1.4821 (6.9); 1.4654 (6.9); 1.2567 (0.7); 0.1465 (0.5); - 0.0002 (120.9); -0.1490 (0.7) I.1-178: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6458 (2.5); 8.6397 (3.1); 8.5920 (2.7); 8.5860 (2.2); 8.2301 (3.1); 8.2256 (1.1); 8.2137 (1.1); 8.2090 (3.6); 8.0676 (2.5); 8.0625 (2.6); 7.7410 (3.4); 7.7364 (1.1); 7.7245 (1.0); 7.7199 (3.2); 7.6959 (1.2); 7.6907 (1.2); 7.6751 (1.6); 7.6699 (1.5); 7.5307 (2.9); 7.5099 (2.2); 7.2984 (0.6); 7.2797 (0.6); 7.2604 (46.8); 5.6684 (0.7); 5.6497 (0.8); 5.6318 (0.7); 3.9724 (16.0); 1.5484 (5.1); 1.4094 (5.4); 1.3927 (5.4); 1.2648 (0.6); 0.8820 (0.8); 0.0080 (1.8); -0.0002 (67.7); -0.0084 (2.0) BCS241005-Abroad STR 144 I.1-179: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6456 (2.6); 8.6395 (3.1); 8.5905 (2.8); 8.5844 (2.2); 8.2298 (3.2); 8.2252 (1.0); 8.2133 (1.2); 8.2087 (3.4); 7.8961 (2.5); 7.8909 (2.6); 7.7396 (3.6); 7.7349 (1.0); 7.7231 (1.2); 7.7186 (3.1); 7.7088 (2.3); 7.6880 (2.9); 7.5580 (1.6); 7.5527 (1.5); 7.5372 (1.3); 7.5320 (1.2); 7.3154 (0.6); 7.2949 (0.6); 7.2603 (56.6); 5.6688 (0.7); 5.6520 (0.8); 5.6325 (0.7); 3.9725 (16.0); 1.5455 (12.6); 1.4074 (5.5); 1.3907 (5.5); 0.0079 (2.8); -0.0002 (82.1); -0.0085 (2.2) I.1-180: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6880 (0.7); 8.6620 (0.8); 8.6559 (0.6); 8.0978 (0.7); 8.0766 (0.8); 7.9246 (0.5); 7.8602 (0.8); 7.8390 (0.6); 5.7571 (1.2); 3.8900 (2.8); 3.3195 (16.0); 2.5240 (0.7); 2.5193 (0.9); 2.5105 (13.1); 2.5060 (28.2); 2.5014 (39.0); 2.4968 (26.7); 2.4923 (11.7); 1.5030 (0.8); 1.4858 (0.8); 0.0080 (0.6); -0.0002 (20.7); -0.0085 (0.6) I.1-181: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6534 (2.5); 8.6473 (3.3); 8.6123 (2.9); 8.6062 (2.2); 8.3395 (2.0); 8.3353 (2.0); 8.3118 (1.5); 8.2898 (1.7); 8.2476 (3.3); 8.2430 (1.1); 8.2310 (1.2); 8.2264 (3.6); 7.9738 (1.4); 7.9693 (1.3); 7.9517 (1.2); 7.9472 (1.2); 7.9262 (1.3); 7.9055 (1.4); 7.8762 (1.5); 7.8737 (1.5); 7.8576 (1.7); 7.8551 (1.5); 7.7911 (3.6); 7.7865 (1.2); 7.7746 (1.1); 7.7700 (3.3); 7.5087 (0.6); 7.4895 (0.7); 7.4145 (1.4); 7.3947 (1.7); 7.3754 (1.2); 7.2603 (32.5); 5.7713 (0.7); 5.7525 (0.8); 5.7350 (0.7); 3.9774 (16.0); 1.5758 (0.8); 1.4711 (5.5); 1.4543 (5.5); 0.0080 (1.5); -0.0002 (46.8); -0.0084 (1.4) I.1-182: 1H-NMR (400.6 MHz, CDCl3): δ= 9.0869 (4.2); 8.6503 (2.4); 8.6443 (3.1); 8.6064 (2.9); 8.6004 (2.3); 8.5699 (2.4); 8.5667 (2.3); 8.2418 (3.4); 8.2372 (1.3); 8.2252 (1.5); 8.2207 (3.7); 8.0499 (1.5); 8.0291 (2.6); 7.9793 (1.7); 7.9754 (1.6); 7.9583 (1.0); 7.9544 (1.0); 7.7803 (3.7); 7.7757 (1.4); 7.7637 (1.4); 7.7592 (3.4); 7.5558 (0.8); 7.5366 (0.8); 7.2624 (18.9); 5.7570 (0.8); 5.7398 (0.9); 5.7206 (0.8); 3.9758 (16.0); 2.9565 (0.6); 2.8849 (0.6); 2.0453 (0.6); 1.4514 (5.8); 1.4347 (5.8); 1.2591 (1.1); 1.2561 (1.1); 1.2439 (0.5); 0.0079 (0.8); -0.0002 (14.0); -0.0084 (0.6) I.1-183:1H-NMR (400.6 MHz, CDCl3): δ= 8.6606 (2.6); 8.6546 (3.2); 8.6083 (2.9); 8.6023 (2.4); 8.4616 (4.0); 8.4581 (4.2); 8.2462 (3.3); 8.2416 (1.1); 8.2297 (1.1); 8.2251 (3.7); 8.2051 (1.6); 8.2013 (2.8); 8.1975 (1.4); 8.0797 (2.2); 8.0733 (2.2); 7.7954 (2.2); 7.7912 (2.2); 7.7609 (3.6); 7.7563 (1.1); 7.7444 (1.1); 7.7398 (3.3); 7.5023 (0.7); 7.4819 (0.7); 7.2609 (53.7); 6.5656 (1.6); 6.5611 (1.8); 6.5593 (1.8); 6.5548 (1.6); 5.7189 (0.7); 5.7011 (0.8); 5.6826 (0.7); 4.1310 (1.4); 4.1132 (1.4); 3.9773 (16.0); 3.1523 (15.2); 2.1032 (0.7); 2.0455 (6.4); 1.5747 (2.6); 1.4649 (5.2); 1.4482 (5.3); 1.2843 (0.7); 1.2775 (1.9); 1.2596 (4.3); 1.2418 (1.8); 0.0079 (1.9); -0.0002 (67.6); -0.0085 (1.9) BCS241005-Abroad STR 145 I.1-185: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6810 (8.8); 8.6749 (10.7); 8.6166 (9.3); 8.6105 (7.7); 8.2636 (10.1); 8.2591 (3.4); 8.2471 (3.7); 8.2425 (11.5); 8.1095 (8.7); 8.1043 (8.7); 7.7709 (11.0); 7.7664 (3.4); 7.7544 (3.7); 7.7499 (10.2); 7.7382 (4.4); 7.7330 (4.2); 7.7174 (5.2); 7.7122 (5.0); 7.5561 (2.6); 7.5395 (11.2); 7.5188 (8.2); 7.2611 (48.3); 5.7509 (0.6); 5.7339 (2.2); 5.7151 (2.6); 5.6977 (2.2); 5.6815 (0.5); 4.1502 (0.9); 4.1323 (2.6); 4.1145 (2.7); 4.0967 (0.9); 2.1333 (10.0); 2.0472 (12.2); 1.4796 (16.0); 1.4629 (16.0); 1.4322 (1.8); 1.2780 (3.4); 1.2602 (7.2); 1.2423 (4.4); 1.2225 (0.8); 0.0079 (2.1); -0.0002 (69.0); - 0.0085 (2.0) I.1-187: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6705 (6.5); 8.6644 (9.0); 8.6326 (8.0); 8.6265 (6.2); 8.3468 (5.1); 8.2703 (9.0); 8.2494 (9.8); 8.0544 (5.0); 7.9304 (2.4); 7.9089 (3.8); 7.9049 (3.7); 7.8367 (11.4); 7.8152 (10.0); 7.8017 (9.7); 7.7808 (8.6); 7.6413 (3.8); 7.6370 (4.3); 7.6290 (2.4); 7.6199 (3.5); 7.6153 (3.7); 7.5188 (1.4); 7.2900 (1.3); 7.2604 (262.6); 6.9968 (1.5); 5.8245 (1.8); 5.8068 (2.4); 5.7884 (1.9); 3.4937 (2.8); 1.5182 (16.0); 1.5015 (15.6); 1.2563 (1.6); 0.1587 (1.2); 0.1458 (1.4); 0.0295 (1.3); 0.0080 (10.0); -0.0002 (334.4); -0.0084 (10.0); -0.1494 (1.4) I.1-188:1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4724 (0.8); 8.6541 (0.6); 8.0614 (0.5); 3.3942 (0.5); 3.3812 (0.5); 3.3179 (16.0); 2.6744 (0.5); 2.6697 (0.7); 2.6652 (0.5); 2.5235 (1.9); 2.5188 (2.6); 2.5100 (40.1); 2.5055 (87.2); 2.5009 (121.8); 2.4963 (83.7); 2.4918 (36.7); 2.3280 (0.7); 1.4866 (0.6); 1.4694 (0.6); 1.2351 (0.6); 0.0080 (2.5); -0.0002 (91.0); -0.0085 (2.5) I.1-189: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6450 (2.4); 8.6395 (2.9); 8.5889 (3.0); 8.5830 (2.4); 8.2576 (3.7); 8.2374 (4.0); 8.0577 (2.8); 8.0531 (2.8); 7.7418 (4.0); 7.7215 (3.7); 7.7051 (2.1); 7.6844 (3.1); 7.6014 (1.7); 7.5971 (1.6); 7.5808 (1.2); 7.5763 (1.1); 7.3003 (0.9); 7.2800 (1.0); 7.2607 (16.2); 5.6656 (0.9); 5.6479 (1.2); 5.6301 (0.9); 4.5388 (2.0); 4.5293 (2.3); 4.5250 (2.2); 4.5155 (2.1); 3.7752 (2.4); 3.7637 (3.2); 3.7518 (2.2); 3.4587 (16.0); 1.5708 (8.4); 1.4323 (0.5); 1.4018 (6.0); 1.3852 (6.0); 1.2560 (2.0); 0.8822 (0.6); -0.0002 (19.2); -0.0070 (0.8) I.1-190:1H-NMR (400.6 MHz, CDCl3): δ= 8.6451 (2.2); 8.6390 (2.6); 8.5900 (2.4); 8.5840 (1.9); 8.2500 (2.7); 8.2455 (0.9); 8.2335 (0.9); 8.2290 (2.9); 8.0575 (2.2); 8.0524 (2.2); 7.7404 (3.0); 7.7359 (0.9); 7.7238 (0.9); 7.7194 (2.6); 7.7064 (1.8); 7.6857 (2.6); 7.6014 (1.4); 7.5962 (1.3); 7.5807 (1.0); 7.5755 (1.0); 7.2997 (0.6); 7.2795 (0.6); 7.2608 (26.9); 5.6672 (0.6); 5.6501 (0.7); 5.6310 (0.6); 4.5526 (1.4); 4.5406 (1.6); 4.5283 (1.6); 3.8879 (1.7); 3.8757 (1.8); 3.8637 (1.6); 3.7404 (1.7); 3.7321 (1.5); 3.7293 (2.1); 3.7245 (1.4); 3.7173 (2.5); 3.6068 (2.5); 3.5996 (1.4); 3.5947 (2.0); 3.5919 (1.4); 3.5837 (1.6); 3.4045 (16.0); 1.5536 (4.1); 1.4049 (4.4); 1.3881 (4.4); 0.0079 (1.0); -0.0002 (33.4); -0.0085 (0.9) BCS241005-Abroad STR 146 I.1-191: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6448 (2.5); 8.6387 (3.1); 8.5868 (2.8); 8.5808 (2.3); 8.2262 (3.2); 8.2218 (1.0); 8.2098 (1.1); 8.2052 (3.5); 8.0581 (2.6); 8.0529 (2.6); 7.7258 (3.5); 7.7212 (1.1); 7.7047 (5.2); 7.6839 (3.1); 7.6008 (1.6); 7.5956 (1.6); 7.5801 (1.1); 7.5749 (1.1); 7.2974 (0.6); 7.2780 (0.7); 7.2607 (28.4); 5.6697 (0.7); 5.6524 (0.8); 5.6334 (0.7); 5.3174 (1.0); 5.3018 (1.4); 5.2862 (1.0); 1.5622 (3.7); 1.4149 (15.0); 1.3993 (16.0); 1.3858 (5.4); 0.0079 (1.1); -0.0002 (35.5); -0.0084 (1.0) I.1-192: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6364 (2.6); 8.6304 (3.1); 8.5637 (2.7); 8.5577 (2.3); 8.2347 (3.2); 8.2301 (1.1); 8.2182 (1.1); 8.2135 (3.7); 8.2094 (0.6); 7.7549 (3.5); 7.7502 (1.1); 7.7384 (1.1); 7.7338 (3.3); 7.7296 (0.5); 7.5415 (1.3); 7.5375 (1.5); 7.5215 (1.6); 7.5176 (1.7); 7.4596 (1.4); 7.4557 (1.4); 7.4405 (1.8); 7.4365 (1.5); 7.2757 (1.8); 7.2607 (27.2); 7.2562 (3.0); 7.2365 (1.3); 7.1788 (0.5); 5.6964 (0.7); 5.6796 (0.8); 5.6768 (0.8); 5.6597 (0.7); 3.9736 (16.0); 2.0453 (1.1); 1.5475 (11.2); 1.4429 (5.8); 1.4262 (5.8); 1.2596 (0.7); 0.0079 (1.0); -0.0002 (33.4); -0.0085 (1.0) I.1-193: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6325 (2.6); 8.6264 (3.1); 8.5704 (2.7); 8.5644 (2.2); 8.2332 (0.6); 8.2290 (3.3); 8.2244 (1.2); 8.2125 (1.2); 8.2078 (3.7); 7.7482 (3.6); 7.7437 (1.3); 7.7317 (1.1); 7.7270 (3.3); 7.6324 (2.5); 7.6116 (2.8); 7.4355 (2.6); 7.4306 (2.8); 7.4133 (0.6); 7.3934 (0.6); 7.3196 (1.8); 7.3146 (1.6); 7.2987 (1.6); 7.2938 (1.5); 7.2609 (18.6); 5.6894 (0.8); 5.6700 (0.9); 5.6531 (0.7); 3.9714 (16.0); 2.0452 (0.8); 1.5531 (5.0); 1.4385 (5.8); 1.4218 (5.7); 1.2595 (0.6); 0.0079 (0.8); -0.0002 (22.9); -0.0085 (0.7) I.1-194: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6583 (7.6); 8.6522 (8.7); 8.5860 (7.9); 8.5800 (6.7); 8.2675 (9.3); 8.2465 (10.2); 7.7821 (10.0); 7.7611 (9.3); 7.5513 (4.0); 7.5473 (4.4); 7.5314 (4.5); 7.5274 (5.0); 7.5191 (0.9); 7.4964 (4.1); 7.4925 (3.8); 7.4772 (5.1); 7.4733 (4.4); 7.3325 (2.3); 7.3135 (2.5); 7.2860 (5.2); 7.2662 (11.3); 7.2608 (113.8); 7.2468 (4.1); 6.9972 (0.6); 5.7559 (0.6); 5.7399 (2.1); 5.7230 (2.5); 5.7035 (2.1); 5.6858 (0.5); 1.4888 (16.0); 1.4722 (15.9); 0.1455 (0.6); 0.0330 (0.8); 0.0079 (4.8); -0.0002 (133.5); -0.0085 (5.3); -0.1494 (0.7) I.1-195: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6756 (6.5); 8.6696 (7.6); 8.6013 (7.8); 8.5953 (6.8); 8.2581 (10.1); 8.2373 (11.3); 7.7767 (10.6); 7.7558 (10.0); 7.6904 (7.7); 7.6696 (8.7); 7.6211 (2.4); 7.6013 (2.5); 7.4466 (8.8); 7.4416 (9.4); 7.3332 (5.4); 7.3282 (4.9); 7.3123 (4.8); 7.3073 (4.5); 7.2607 (70.2); 5.7662 (0.6); 5.7495 (2.3); 5.7304 (2.9); 5.7133 (2.3); 5.6970 (0.6); 1.5062 (16.0); 1.4896 (15.9); 0.0281 (0.5); 0.0079 (3.7); -0.0002 (101.8); -0.0084 (3.4) BCS241005-Abroad STR 147 I.1-196: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0822 (0.6); 9.0649 (0.6); 8.7318 (1.6); 8.7257 (2.0); 8.6890 (2.4); 8.6829 (1.9); 8.1291 (2.1); 8.1243 (0.7); 8.1125 (0.8); 8.1077 (2.5); 7.8287 (2.3); 7.8238 (0.7); 7.8121 (0.7); 7.8073 (2.1); 7.4841 (2.8); 7.4830 (3.1); 7.4799 (4.6); 7.2215 (1.3); 7.2183 (1.4); 7.2173 (1.6); 7.2142 (1.2); 5.2809 (0.7); 3.9089 (9.1); 3.3198 (16.0); 2.5409 (0.6); 2.5296 (0.7); 2.5241 (1.1); 2.5193 (1.4); 2.5106 (11.8); 2.5060 (24.6); 2.5014 (33.8); 2.4969 (23.5); 2.4923 (10.5); 1.4512 (2.7); 1.4342 (2.7); -0.0002 (14.6) I.1-197: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7242 (1.1); 8.7181 (1.4); 8.6830 (1.8); 8.6769 (1.4); 8.1307 (1.5); 8.1141 (0.6); 8.1093 (1.8); 7.8762 (1.4); 7.8716 (1.4); 7.8265 (1.7); 7.8217 (0.5); 7.8099 (0.5); 7.8052 (1.5); 7.6208 (0.8); 7.6160 (0.7); 7.6004 (0.8); 7.5956 (0.8); 7.1893 (1.4); 7.1689 (1.2); 5.2441 (0.5); 3.9092 (6.4); 3.3193 (16.0); 2.5327 (0.6); 2.5238 (1.2); 2.5192 (1.5); 2.5104 (11.8); 2.5058 (24.2); 2.5013 (33.0); 2.4967 (22.7); 2.4921 (10.0); 1.4391 (1.9); 1.4220 (1.8); -0.0002 (14.0) I.1-198: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1470 (2.0); 9.1017 (0.9); 9.0842 (1.0); 8.7285 (2.4); 8.7224 (3.1); 8.6883 (3.6); 8.6823 (2.9); 8.1075 (3.1); 8.1029 (1.0); 8.0911 (1.1); 8.0863 (3.7); 8.0821 (0.5); 7.8023 (3.4); 7.7975 (1.0); 7.7858 (1.0); 7.7811 (3.0); 7.4879 (4.8); 7.4845 (7.0); 7.2432 (1.9); 7.2392 (2.6); 7.2358 (1.7); 5.3010 (0.6); 5.2839 (1.0); 5.2667 (0.7); 3.3349 (16.0); 2.5252 (1.0); 2.5205 (1.4); 2.5117 (18.2); 2.5072 (39.4); 2.5026 (54.3); 2.4981 (37.1); 2.4935 (16.0); 1.4496 (3.8); 1.4326 (3.8); 0.0080 (1.2); -0.0002 (42.9); -0.0085 (1.2) I.1-199: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7200 (1.1); 8.7139 (1.5); 8.6820 (1.8); 8.6759 (1.4); 8.1072 (1.4); 8.0908 (0.5); 8.0861 (1.7); 7.8816 (1.5); 7.8769 (1.5); 7.7972 (1.6); 7.7760 (1.4); 7.6223 (0.8); 7.6176 (0.7); 7.6019 (0.8); 7.5972 (0.8); 7.1931 (1.4); 7.1728 (1.3); 3.3317 (16.0); 2.6708 (0.6); 2.5245 (1.6); 2.5199 (2.3); 2.5111 (31.3); 2.5065 (67.4); 2.5020 (92.7); 2.4974 (63.2); 2.4929 (27.3); 2.3290 (0.5); 1.4384 (1.8); 1.4214 (1.8); 0.0080 (2.6); -0.0002 (85.3); -0.0060 (0.6); -0.0085 (2.2) I.1-200: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6441 (2.5); 8.6381 (3.1); 8.5862 (2.8); 8.5801 (2.3); 8.2336 (0.5); 8.2293 (3.2); 8.2248 (1.0); 8.2129 (1.1); 8.2083 (3.5); 7.7458 (0.6); 7.7416 (3.5); 7.7371 (1.1); 7.7252 (1.0); 7.7207 (3.2); 7.6995 (0.5); 7.6940 (0.6); 7.6807 (0.6); 7.6749 (0.7); 7.6673 (0.6); 7.6540 (0.5); 7.6485 (0.6); 7.5572 (0.6); 7.3179 (0.5); 7.2984 (0.5); 7.2625 (7.1); 7.2416 (0.8); 7.2369 (0.7); 7.2205 (0.6); 7.2174 (0.8); 7.1963 (0.5); 5.6722 (0.7); 5.6552 (0.8); 5.6360 (0.7); 3.9723 (16.0); 1.6101 (1.4); 1.4041 (5.7); 1.3874 (5.7); -0.0002 (8.8) BCS241005-Abroad STR 148 I.1-201: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6503 (2.6); 8.6442 (3.1); 8.5942 (2.8); 8.5881 (2.2); 8.2358 (0.6); 8.2315 (3.2); 8.2270 (1.0); 8.2151 (1.1); 8.2105 (3.5); 8.2062 (0.5); 7.7412 (0.6); 7.7370 (3.5); 7.7323 (1.1); 7.7205 (1.1); 7.7160 (3.2); 7.3551 (0.5); 7.3490 (0.7); 7.3435 (1.7); 7.3378 (1.9); 7.3346 (1.3); 7.3275 (1.5); 7.3242 (2.0); 7.3186 (1.5); 7.2616 (10.6); 6.9782 (0.6); 6.9626 (0.7); 6.9568 (1.2); 6.9510 (0.6); 6.9355 (0.6); 5.6690 (0.7); 5.6519 (0.8); 5.6327 (0.7); 3.9737 (16.0); 1.5869 (3.1); 1.4056 (5.7); 1.3889 (5.7); -0.0002 (13.7) I.1-202: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6600 (2.6); 8.6539 (3.1); 8.5998 (2.8); 8.5938 (2.3); 8.2350 (3.3); 8.2304 (1.0); 8.2184 (1.1); 8.2139 (3.5); 7.8384 (2.7); 7.8336 (2.9); 7.7325 (3.6); 7.7278 (1.1); 7.7113 (4.4); 7.3439 (0.6); 7.3247 (0.6); 7.2605 (30.3); 5.6627 (0.7); 5.6450 (0.8); 5.6266 (0.7); 3.9747 (16.0); 2.0455 (0.6); 1.5524 (8.7); 1.4156 (5.5); 1.3989 (5.4); 0.0079 (1.3); -0.0002 (42.7); -0.0085 (1.2) I.1-203: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7001 (8.8); 8.6940 (10.4); 8.6236 (9.2); 8.6174 (8.0); 8.2866 (10.0); 8.2823 (3.3); 8.2701 (3.6); 8.2656 (11.2); 8.1678 (0.6); 8.1632 (0.6); 7.8927 (9.6); 7.8878 (10.1); 7.7816 (11.0); 7.7772 (3.5); 7.7650 (3.4); 7.7606 (10.3); 7.7556 (2.5); 7.7515 (4.5); 7.7480 (5.6); 7.7437 (4.1); 7.6273 (2.6); 7.6078 (2.7); 7.2615 (53.2); 5.7305 (0.5); 5.7139 (2.1); 5.6959 (2.8); 5.6778 (2.2); 5.6609 (0.6); 2.8241 (0.8); 1.4839 (15.2); 1.4672 (16.0); 1.4322 (1.0); 1.3034 (0.7); 1.2844 (1.3); 1.2815 (1.3); 1.2635 (3.6); 1.2226 (0.6); 0.8986 (1.6); 0.8819 (5.7); 0.8641 (2.5); -0.0002 (67.5); -0.0084 (3.5); - 0.0340 (0.5) I.1-204: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1056 (2.7); 8.9760 (2.8); 8.9599 (2.8); 8.6775 (4.5); 8.6720 (6.0); 8.6537 (6.0); 8.6483 (4.4); 8.0702 (6.4); 8.0499 (7.2); 7.8909 (1.4); 7.8701 (1.9); 7.8421 (1.4); 7.7965 (7.3); 7.7762 (6.3); 7.7065 (2.0); 7.5365 (1.1); 7.5155 (2.1); 7.4902 (2.0); 7.4687 (0.9); 5.3127 (1.8); 5.2954 (2.6); 5.2792 (1.7); 3.3258 (16.0); 2.6726 (0.6); 2.5035 (85.0); 2.3307 (0.6); 1.4606 (9.6); 1.4436 (9.4); -0.0002 (24.8) I.1-205: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1090 (2.5); 9.0405 (3.9); 9.0241 (3.9); 8.6839 (6.5); 8.6780 (9.2); 8.6596 (9.3); 8.6537 (6.5); 8.0712 (9.4); 8.0507 (10.9); 7.7908 (10.7); 7.7703 (9.4); 7.5232 (6.4); 7.5074 (6.1); 7.4583 (1.4); 7.4526 (1.9); 7.4356 (2.6); 7.4299 (3.5); 7.4128 (1.4); 7.4074 (1.8); 5.3342 (0.7); 5.3180 (2.5); 5.3012 (3.7); 5.2843 (2.4); 5.2672 (0.6); 3.3922 (0.6); 3.3744 (0.8); 3.3282 (16.0); 2.6730 (0.6); 2.5080 (72.5); 2.5042 (90.1); 2.5003 (70.4); 2.3313 (0.6); 1.4690 (13.9); 1.4518 (13.6); 1.0914 (0.9); -0.0002 (31.4) I.1-206: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6553 (2.2); 8.6492 (2.8); 8.6018 (2.5); 8.5958 (2.0); 8.2319 (2.9); 8.2109 (3.3); 7.8222 (0.5); 7.8095 (10.0); 7.7300 (3.2); 7.7090 (3.0); 7.3089 (0.7); 7.2891 (0.8); 7.2604 (32.0); 5.6526 (0.7); 5.6336 (0.8); 5.6165 (0.7); 3.9742 (14.0); 1.5470 (16.0); 1.4084 (5.1); 1.3917 (5.1); 0.0078 (1.8); -0.0002 (45.7); -0.0085 (1.5) BCS241005-Abroad STR 149 I.1-207: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6549 (2.6); 8.6489 (3.2); 8.6023 (2.8); 8.5962 (2.3); 8.2317 (3.3); 8.2273 (1.2); 8.2152 (1.2); 8.2106 (3.7); 7.9671 (2.8); 7.9621 (3.0); 7.8507 (3.0); 7.8457 (2.8); 7.7308 (3.6); 7.7263 (1.3); 7.7143 (1.2); 7.7097 (3.3); 7.2956 (0.8); 7.2765 (0.8); 7.2607 (20.6); 5.6498 (0.8); 5.6310 (0.9); 5.6137 (0.7); 3.9739 (16.0); 1.5611 (4.2); 1.4097 (5.6); 1.3930 (5.6); 1.2641 (0.8); 0.8819 (1.3); 0.8642 (0.5); 0.0079 (1.1); -0.0002 (29.2); -0.0085 (1.0) I.1-208: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6372 (1.6); 8.6312 (2.0); 8.5928 (1.8); 8.5867 (1.4); 8.2297 (2.1); 8.2251 (0.7); 8.2131 (0.8); 8.2086 (2.3); 8.1424 (0.9); 8.1383 (1.6); 8.1341 (0.8); 7.8494 (0.6); 7.8468 (0.7); 7.8428 (0.5); 7.8297 (0.6); 7.8271 (0.7); 7.8231 (0.5); 7.7747 (0.6); 7.7719 (0.7); 7.7682 (0.6); 7.7551 (1.1); 7.7510 (3.0); 7.7342 (0.8); 7.7297 (2.0); 7.2612 (13.2); 7.2021 (0.8); 7.1826 (1.5); 7.1631 (0.7); 5.6592 (0.6); 3.9715 (10.2); 1.5616 (16.0); 1.4117 (3.6); 1.3950 (3.6); 0.0078 (0.6); -0.0002 (13.3) I.1-209: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6324 (2.1); 8.6263 (2.5); 8.5769 (2.2); 8.5708 (1.8); 8.2256 (2.5); 8.2210 (0.9); 8.2091 (1.0); 8.2044 (2.9); 7.8052 (2.7); 7.8006 (0.9); 7.7886 (1.0); 7.7839 (3.2); 7.7493 (2.8); 7.7447 (1.0); 7.7327 (0.9); 7.7281 (2.6); 7.5477 (3.1); 7.5430 (1.0); 7.5310 (0.9); 7.5264 (2.7); 7.3187 (0.5); 7.2989 (0.6); 7.2613 (12.7); 5.6814 (0.6); 5.6641 (0.7); 5.6451 (0.6); 3.9698 (12.7); 1.5677 (16.0); 1.4027 (4.4); 1.3860 (4.4); 0.0080 (0.5); -0.0002 (13.4) I.1-210: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6487 (2.6); 8.6427 (3.4); 8.6056 (3.1); 8.5995 (2.4); 8.2302 (3.5); 8.2260 (1.3); 8.2136 (1.4); 8.2093 (4.0); 8.1806 (1.6); 8.1769 (3.0); 8.1732 (1.8); 8.0648 (6.5); 8.0611 (6.2); 7.7371 (3.8); 7.7328 (1.4); 7.7204 (1.3); 7.7161 (3.6); 7.2631 (8.1); 7.2369 (0.8); 7.2174 (0.8); 5.6412 (0.8); 5.6236 (1.0); 5.6050 (0.8); 3.9728 (16.0); 1.5999 (1.1); 1.4088 (5.9); 1.3920 (5.8); - 0.0002 (11.7) I.1-211: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0227 (0.6); 9.0062 (0.6); 8.6809 (1.3); 8.6748 (1.9); 8.6527 (2.2); 8.6467 (1.5); 8.2751 (1.5); 8.2700 (1.4); 8.0808 (1.8); 8.0761 (0.6); 8.0643 (0.7); 8.0595 (2.2); 7.9742 (1.5); 7.9537 (1.7); 7.8066 (2.1); 7.8018 (0.6); 7.7900 (0.6); 7.7853 (1.8); 7.5044 (0.8); 7.4992 (0.8); 7.4839 (0.8); 7.4786 (0.8); 5.2694 (0.6); 3.9012 (7.9); 3.3207 (16.0); 2.5248 (1.2); 2.5201 (1.5); 2.5113 (11.1); 2.5068 (22.8); 2.5022 (31.1); 2.4976 (21.4); 2.4931 (9.4); 1.9893 (0.5); 1.4496 (2.2); 1.4323 (2.1); 0.8576 (0.8); 0.0081 (0.6); -0.0002 (19.4); -0.0085 (0.6) I.1-212:1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1465 (0.9); 9.1835 (3.2); 9.1682 (3.2); 8.6856 (6.3); 8.6655 (6.3); 8.0659 (7.1); 8.0460 (8.5); 8.0227 (16.0); 7.7791 (7.7); 7.7592 (6.7); 5.3117 (2.0); 5.2951 (2.8); 5.2788 (2.0); 3.3423 (10.3); 2.6722 (0.7); 2.5058 (83.1); 2.3339 (0.6); 1.4786 (10.3); 1.4618 (10.0); -0.0002 (25.0) BCS241005-Foreign STR 150 I.1-213: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1290 (3.1); 9.1847 (3.6); 9.1696 (3.5); 8.6859 (6.8); 8.6651 (6.8); 8.1539 (6.7); 8.0677 (8.1); 8.0462 (12.1); 7.7813 (8.2); 7.7616 (7.2); 5.3081 (2.3); 5.2929 (3.1); 5.2765 (2.1); 3.3406 (16.0); 2.6728 (0.9); 2.5061 (89.5); 2.3325 (0.6); 1.4757 (11.3); 1.4593 (10.6); -0.0002 (23.7) I.1-214:1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1250 (6.2); 9.0143 (4.7); 8.9981 (4.7); 8.6791 (7.8); 8.6732 (10.9); 8.6541 (11.3); 8.6482 (7.7); 8.1770 (9.4); 8.0809 (11.3); 8.0603 (13.0); 7.8753 (4.9); 7.8559 (5.1); 7.8092 (14.6); 7.7885 (13.7); 7.2470 (4.2); 7.2275 (7.7); 7.2080 (3.7); 5.3253 (0.8); 5.3090 (2.8); 5.2922 (4.3); 5.2753 (2.8); 5.2587 (0.7); 3.6178 (1.2); 3.6014 (2.8); 3.5851 (1.2); 3.3910 (1.4); 3.3735 (1.5); 3.3382 (13.4); 2.6732 (0.8); 2.5082 (106.3); 2.5043 (129.5); 2.3315 (0.8); 1.7754 (1.2); 1.7593 (3.1); 1.7512 (1.5); 1.7430 (1.2); 1.4523 (16.0); 1.4352 (15.7); 1.1085 (1.4); 1.0910 (2.6); 1.0735 (1.3); -0.0002 (62.9) I.1-215: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6510 (2.6); 8.6449 (3.1); 8.5889 (2.7); 8.5828 (2.2); 8.2418 (0.5); 8.2376 (3.2); 8.2329 (1.0); 8.2211 (1.1); 8.2163 (3.5); 8.2122 (0.6); 7.9394 (1.8); 7.9192 (2.3); 7.7606 (0.6); 7.7564 (3.5); 7.7517 (1.1); 7.7399 (1.1); 7.7352 (3.3); 7.7308 (0.7); 7.7235 (2.4); 7.7030 (2.0); 7.4291 (0.6); 7.4094 (0.6); 7.2626 (12.6); 5.7114 (0.7); 5.6944 (0.8); 5.6751 (0.7); 3.9756 (16.0); 1.6060 (0.7); 1.4257 (5.4); 1.4090 (5.4); 0.0079 (0.6); -0.0002 (18.6); -0.0085 (0.5) I.1-216: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6499 (2.6); 8.6438 (3.1); 8.5886 (2.6); 8.5825 (2.2); 8.2374 (3.1); 8.2327 (1.0); 8.2209 (1.1); 8.2161 (3.6); 8.2119 (0.6); 7.9390 (1.8); 7.9188 (2.2); 7.7603 (0.6); 7.7561 (3.4); 7.7513 (1.1); 7.7395 (1.1); 7.7348 (3.2); 7.7303 (0.7); 7.7233 (2.4); 7.7029 (1.9); 7.4275 (0.5); 7.4078 (0.6); 7.2626 (12.1); 5.7112 (0.7); 5.6941 (0.8); 5.6919 (0.8); 5.6749 (0.7); 3.9755 (16.0); 1.5913 (2.0); 1.4249 (5.3); 1.4081 (5.3); 0.8818 (0.6); -0.0002 (17.5); -0.0085 (0.5) I.1-217: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1260 (7.3); 8.9539 (4.1); 8.9374 (4.3); 8.6714 (7.7); 8.6653 (12.7); 8.6492 (13.6); 8.6431 (8.6); 8.0768 (11.3); 8.0726 (4.2); 8.0603 (4.4); 8.0559 (14.1); 7.8184 (12.2); 7.8136 (6.1); 7.8086 (13.8); 7.8024 (6.5); 7.7972 (16.0); 7.7920 (6.1); 7.7877 (12.0); 7.6060 (14.1); 7.6015 (4.5); 7.5893 (4.1); 7.5848 (12.1); 5.3246 (0.5); 5.3076 (2.5); 5.2907 (3.9); 5.2738 (2.6); 5.2566 (0.6); 3.3393 (5.7); 2.6733 (0.6); 2.5269 (1.7); 2.5222 (2.6); 2.5133 (32.7); 2.5089 (68.8); 2.5044 (93.6); 2.4999 (66.2); 2.4955 (30.1); 2.3315 (0.6); 1.4434 (14.7); 1.4262 (14.6); 1.0909 (0.6); 0.0080 (2.5); -0.0002 (73.8); -0.0085 (2.4) BCS241005-Abroad STR 151 I.1-218: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6676 (2.5); 8.6616 (3.0); 8.5885 (2.3); 8.5824 (2.0); 8.2292 (3.1); 8.2243 (1.0); 8.2127 (1.0); 8.2078 (3.4); 8.2036 (0.5); 7.7071 (3.1); 7.7022 (1.0); 7.6905 (0.9); 7.6857 (2.9); 7.3678 (6.2); 7.2626 (6.9); 5.6326 (0.6); 5.6157 (0.6); 5.6131 (0.6); 5.5962 (0.6); 3.9738 (16.0); 2.0460 (0.8); 1.6226 (0.6); 1.4059 (4.8); 1.3892 (4.8); 1.2643 (0.5); 1.2599 (0.8); 0.8818 (1.1); - 0.0002 (10.5) I.1-219: 1H-NMR (400.6 MHz, CDCl3): δ= 8.8457 (1.5); 8.8430 (1.7); 8.8256 (1.6); 8.8230 (1.6); 8.6486 (1.3); 8.6425 (3.6); 8.6363 (4.4); 8.6303 (1.6); 8.2365 (3.1); 8.2317 (1.0); 8.2200 (1.0); 8.2151 (3.5); 8.2109 (0.5); 7.7663 (3.4); 7.7615 (1.1); 7.7498 (1.0); 7.7449 (3.1); 7.5407 (0.9); 7.5380 (1.2); 7.5219 (2.3); 7.5192 (2.2); 7.4953 (2.1); 7.4753 (2.1); 7.4565 (1.1); 7.2606 (22.0); 5.7167 (0.6); 5.6999 (0.7); 5.6962 (0.7); 5.6794 (0.6); 5.2999 (2.2); 3.9761 (16.0); 1.4943 (5.0); 1.4776 (5.0); 1.2544 (1.0); 0.0079 (0.9); -0.0002 (32.9); -0.0085 (0.9) I.1-220: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4210 (2.0); 9.4042 (2.1); 8.7135 (4.9); 8.7074 (7.8); 8.6887 (8.9); 8.6826 (5.9); 8.0722 (0.9); 8.0680 (6.9); 8.0634 (2.3); 8.0516 (2.3); 8.0468 (8.4); 8.0427 (1.3); 7.9924 (16.0); 7.7557 (1.2); 7.7516 (7.7); 7.7469 (2.5); 7.7351 (2.2); 7.7304 (7.0); 7.7263 (1.1); 5.2889 (1.4); 5.2718 (2.3); 5.2548 (1.5); 3.3296 (0.8); 3.1716 (2.5); 2.5274 (0.7); 2.5228 (0.9); 2.5140 (14.5); 2.5094 (32.7); 2.5048 (46.2); 2.5003 (32.5); 2.4957 (14.6); 2.1843 (0.7); 1.9118 (1.2); 1.4917 (8.7); 1.4745 (8.7); 1.3568 (6.1); 1.1824 (0.9); 0.0080 (0.7); -0.0002 (25.3); -0.0085 (0.7) I.1-221:1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0953 (0.6); 9.0773 (0.7); 8.7364 (1.4); 8.7303 (2.1); 8.7047 (2.4); 8.6986 (1.8); 8.5565 (1.1); 8.5545 (1.2); 8.5359 (1.2); 8.5340 (1.2); 8.0787 (2.0); 8.0741 (0.7); 8.0623 (0.7); 8.0575 (2.4); 7.8267 (1.0); 7.8246 (1.2); 7.8077 (1.4); 7.8058 (1.3); 7.7887 (2.2); 7.7839 (0.7); 7.7722 (0.6); 7.7674 (2.0); 7.6344 (1.1); 7.6154 (1.2); 7.6139 (1.3); 7.5950 (1.0); 5.7577 (1.0); 5.4249 (0.6); 3.3214 (16.0); 2.5249 (0.9); 2.5203 (1.2); 2.5115 (16.4); 2.5069 (36.5); 2.5023 (51.3); 2.4977 (36.0); 2.4932 (16.2); 1.4888 (2.5); 1.4719 (2.5); 0.0080 (0.6); -0.0002 (21.1); -0.0085 (0.6) I.1-222: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6427 (1.7); 8.6367 (4.2); 8.6294 (3.3); 8.6233 (1.3); 8.2479 (0.9); 8.2456 (1.6); 8.2420 (3.5); 8.2371 (1.0); 8.2279 (1.0); 8.2255 (2.2); 8.2205 (3.5); 8.2163 (0.5); 7.7580 (3.3); 7.7531 (1.0); 7.7415 (0.9); 7.7366 (3.0); 7.6267 (1.3); 7.6244 (1.6); 7.6234 (1.5); 7.6211 (1.3); 7.6178 (1.3); 7.6149 (1.2); 7.6016 (1.2); 7.5986 (1.1); 7.4276 (0.8); 7.4241 (0.8); 7.4114 (0.7); 7.4077 (1.4); 7.4041 (0.8); 7.3913 (0.7); 7.3878 (0.7); 7.2614 (10.3); 5.7500 (0.6); 5.7332 (0.6); 5.7297 (0.6); 5.7129 (0.6); 5.2997 (2.2); 3.9780 (16.0); 1.4878 (5.0); 1.4711 (5.0); 1.2551 (0.5); -0.0002 (15.3) BCS241005-Abroad STR 152 I.1-223: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6268 (2.1); 8.6207 (3.6); 8.6044 (2.9); 8.5983 (1.7); 8.5872 (1.0); 8.5812 (1.6); 8.5637 (0.8); 8.2234 (0.6); 8.2192 (3.2); 8.2144 (1.0); 8.2027 (1.1); 8.1978 (3.5); 8.1954 (1.9); 8.1905 (0.6); 8.1788 (0.6); 8.1739 (1.7); 7.7443 (0.5); 7.7400 (3.4); 7.7352 (1.0); 7.7235 (1.0); 7.7186 (3.2); 7.7143 (0.9); 7.6925 (0.5); 7.2632 (16.0); 5.6562 (0.6); 5.6393 (0.7); 5.6358 (0.7); 5.6190 (0.6); 5.3003 (2.8); 3.9710 (16.0); 3.9609 (5.1); 3.9533 (0.9); 3.0125 (3.6); 2.3256 (1.1); 1.4261 (6.4); 1.4197 (2.9); 1.4094 (6.1); 1.2922 (0.7); 1.2745 (0.7); 1.2103 (1.4); 1.1512 (0.6); 1.1331 (1.0); 0.0079 (0.6); -0.0002 (23.9); -0.0085 (0.7) I.1-224: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6780 (2.4); 8.6719 (3.1); 8.6322 (2.6); 8.6261 (2.0); 8.2326 (3.2); 8.2278 (1.0); 8.2161 (1.0); 8.2113 (3.4); 8.2071 (0.5); 7.6962 (3.3); 7.6914 (1.0); 7.6797 (1.0); 7.6749 (3.0); 7.2605 (30.5); 5.6443 (0.7); 5.6266 (0.9); 5.6092 (0.7); 3.9771 (16.0); 1.5446 (5.4); 1.4571 (5.2); 1.4405 (5.2); 0.0079 (1.2); -0.0002 (45.3); -0.0085 (1.3) I.1-225: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6481 (2.4); 8.6420 (2.9); 8.5860 (2.4); 8.5799 (2.0); 8.2302 (2.8); 8.2254 (1.0); 8.2137 (1.0); 8.2089 (3.2); 8.2047 (0.5); 7.7302 (3.0); 7.7254 (1.0); 7.7137 (0.9); 7.7089 (2.8); 7.4563 (2.4); 7.4511 (2.5); 7.2607 (27.5); 6.6034 (2.5); 6.5981 (2.5); 5.6451 (0.6); 5.6282 (0.6); 5.6250 (0.6); 5.6082 (0.6); 4.1499 (16.0); 3.9736 (15.4); 1.6086 (0.7); 1.3957 (5.0); 1.3790 (5.0); 0.0079 (1.1); -0.0002 (39.6); -0.0085 (1.1) I.1-226: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8204 (0.9); 8.8032 (0.9); 8.6903 (2.0); 8.6842 (3.2); 8.6646 (3.7); 8.6585 (2.5); 8.0746 (2.8); 8.0699 (1.0); 8.0581 (1.0); 8.0533 (3.4); 8.0492 (0.6); 7.7779 (3.1); 7.7731 (1.0); 7.7613 (0.9); 7.7566 (2.8); 7.4127 (3.2); 7.4075 (3.4); 6.9330 (3.2); 6.9278 (3.2); 5.3203 (0.6); 5.3032 (1.0); 5.2859 (0.6); 3.9079 (16.0); 3.3238 (12.1); 2.5249 (0.6); 2.5202 (0.8); 2.5114 (13.0); 2.5069 (29.3); 2.5023 (41.6); 2.4977 (29.4); 2.4931 (13.4); 1.4368 (3.7); 1.4196 (3.7); 1.3557 (1.6); 0.0080 (1.0); -0.0002 (35.0); -0.0058 (0.5); -0.0085 (1.0) I.1-227: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3567 (2.4); 9.3396 (2.4); 8.7292 (5.9); 8.7231 (8.4); 8.6981 (10.2); 8.6920 (7.4); 8.0917 (1.1); 8.0875 (8.0); 8.0828 (2.8); 8.0710 (2.7); 8.0662 (9.8); 7.9604 (2.1); 7.9576 (3.3); 7.9553 (2.5); 7.9403 (2.6); 7.9382 (3.9); 7.9354 (2.7); 7.8601 (2.1); 7.8583 (4.2); 7.8563 (2.4); 7.8390 (3.0); 7.8370 (5.7); 7.8350 (3.0); 7.8016 (1.4); 7.7974 (8.9); 7.7926 (2.9); 7.7809 (2.4); 7.7762 (8.0); 7.7720 (1.2); 7.7360 (2.5); 7.7329 (2.6); 7.7184 (2.9); 7.7151 (3.7); 7.7117 (2.0); 7.6971 (2.2); 7.6940 (2.2); 7.4734 (2.4); 7.4715 (2.6); 7.4557 (2.6); 7.4536 (4.3); 7.4515 (2.9); 7.4358 (2.1); 7.4338 (2.2); 6.8717 (1.1); 6.6415 (0.7); 5.7581 (7.7); 5.4423 (1.7); 5.4252 (2.8); 5.4080 (1.8); 3.8854 (1.6); 3.3251 (9.5); 2.6719 (0.7); 2.5425 (1.7); 2.5257 (1.4); 2.5211 (2.1); 2.5123 (36.1); 2.5077 (81.6); 2.5031 (115.4); 2.4985 (81.0); 2.4939 (36.4); 2.3302 (0.7); 2.1839 (1.8); 1.9104 (2.0); 1.4918 (10.2); 1.4747 (10.2); 1.3562 (16.0); 1.2334 (0.8); 1.1819 (1.7); 1.1753 (0.6); 0.0080 (2.4); 0.0057 (0.6); -0.0002 (91.7); -0.0085 (2.6) BCS241005-Abroad STR 153 I.1-228: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1272 (0.9); 9.0920 (1.3); 9.0742 (1.4); 8.7221 (3.2); 8.7159 (5.1); 8.6980 (6.0); 8.6919 (4.0); 8.0954 (0.6); 8.0911 (4.6); 8.0864 (1.6); 8.0747 (1.6); 8.0699 (5.5); 8.0658 (0.9); 7.7658 (0.8); 7.7617 (5.1); 7.7569 (1.6); 7.7452 (1.4); 7.7405 (4.7); 7.7362 (0.7); 6.8707 (0.5); 5.7574 (4.1); 5.3032 (1.0); 5.2859 (1.6); 5.2685 (1.0); 3.3222 (16.0); 2.5417 (0.9); 2.5249 (1.0); 2.5203 (1.3); 2.5115 (21.3); 2.5069 (47.8); 2.5023 (67.6); 2.4977 (47.7); 2.4932 (21.6); 2.1835 (0.8); 1.4419 (6.0); 1.4249 (6.0); 1.3556 (7.6); 1.1813 (1.2); 0.0080 (1.4); -0.0002 (53.6); -0.0085 (1.6) I.1-231: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7300 (0.5); 8.6740 (1.1); 8.6680 (1.7); 8.6475 (1.9); 8.6414 (1.4); 8.0718 (1.5); 8.0671 (0.6); 8.0553 (0.6); 8.0506 (1.9); 8.0394 (1.8); 8.0351 (1.8); 7.7890 (1.7); 7.7843 (0.6); 7.7724 (0.5); 7.7678 (1.6); 7.5035 (1.8); 7.4991 (1.7); 5.2339 (0.5); 3.3193 (16.0); 2.5238 (0.8); 2.5192 (1.4); 2.5104 (20.5); 2.5059 (43.7); 2.5013 (60.4); 2.4967 (41.4); 2.4921 (18.1); 1.9887 (1.7); 1.4321 (2.0); 1.4149 (2.0); 1.3551 (0.6); 1.1923 (0.5); 1.1745 (1.1); 1.1567 (0.5); 0.0080 (1.1); 0.0056 (0.5); -0.0002 (32.5); -0.0085 (0.8) I.1-233: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6967 (0.7); 8.6906 (1.2); 8.6708 (1.4); 8.6646 (0.9); 8.3920 (1.2); 8.3910 (1.2); 8.0938 (1.1); 8.0724 (1.3); 7.7884 (1.2); 7.7671 (1.1); 3.9009 (5.1); 3.3190 (16.0); 2.5239 (0.5); 2.5193 (0.8); 2.5105 (11.3); 2.5059 (25.2); 2.5013 (35.4); 2.4967 (24.4); 2.4921 (10.8); 2.2613 (3.9); 1.4059 (1.4); 1.3888 (1.4); -0.0002 (8.6) I.1-234: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7028 (0.6); 8.6966 (0.9); 8.6748 (1.1); 8.6688 (0.8); 8.1014 (0.9); 8.0800 (1.0); 7.7933 (1.0); 7.7719 (0.9); 6.4660 (0.8); 6.4637 (0.8); 3.9031 (3.9); 3.3181 (16.0); 2.5237 (0.7); 2.5190 (0.9); 2.5102 (14.0); 2.5057 (30.9); 2.5011 (43.4); 2.4965 (29.7); 2.4919 (12.9); 2.4317 (2.3); 2.4296 (2.2); 1.4224 (1.1); 1.4053 (1.1); -0.0002 (11.2) I.1-235: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7251 (1.4); 8.7189 (2.1); 8.6938 (2.5); 8.6877 (1.8); 8.1064 (2.1); 8.1016 (0.6); 8.0899 (0.7); 8.0850 (2.5); 7.7959 (2.2); 7.7910 (0.7); 7.7793 (0.6); 7.7745 (2.0); 5.2994 (0.7); 3.9035 (9.4); 3.3184 (16.0); 2.6699 (0.5); 2.6617 (12.8); 2.5407 (0.8); 2.5238 (0.9); 2.5192 (1.3); 2.5104 (18.5); 2.5059 (40.7); 2.5012 (57.2); 2.4966 (39.2); 2.4921 (17.1); 1.9887 (1.6); 1.4472 (2.6); 1.4300 (2.6); 1.1745 (1.0); 0.0080 (1.3); 0.0039 (0.6); 0.0022 (1.7); -0.0002 (44.0); -0.0027 (2.0); -0.0043 (0.6); -0.0085 (1.2) BCS241005-Abroad STR 154 I.1-236: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6910 (1.4); 8.6849 (2.3); 8.6686 (2.7); 8.6624 (1.7); 8.6347 (0.6); 8.6172 (0.6); 8.3948 (2.3); 8.3938 (2.3); 8.0736 (2.0); 8.0689 (0.7); 8.0571 (0.7); 8.0523 (2.4); 7.7611 (2.2); 7.7563 (0.7); 7.7446 (0.6); 7.7399 (2.0); 5.2928 (0.7); 4.0378 (1.3); 4.0201 (1.3); 3.3194 (16.0); 2.6702 (0.6); 2.5407 (1.4); 2.5239 (1.7); 2.5193 (2.3); 2.5105 (31.8); 2.5059 (69.7); 2.5013 (97.5); 2.4967 (66.4); 2.4921 (28.8); 2.3284 (0.6); 2.2682 (7.2); 1.9887 (6.2); 1.9085 (2.0); 1.4059 (2.5); 1.3888 (2.6); 1.3551 (2.3); 1.1923 (1.9); 1.1745 (3.8); 1.1567 (1.8); 0.8525 (0.7); 0.8459 (0.7); 0.0080 (2.1); 0.0048 (0.6); 0.0039 (0.9); 0.0023 (2.7); -0.0002 (74.5); -0.0026 (3.3); -0.0042 (1.1); -0.0051 (0.7); -0.0059 (0.6); -0.0067 (0.6); -0.0085 (2.0) I.1-237: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9422 (2.5); 8.9253 (2.5); 8.6982 (6.1); 8.6921 (9.8); 8.6844 (0.6); 8.6737 (11.7); 8.6676 (8.0); 8.0867 (1.3); 8.0825 (9.0); 8.0778 (2.9); 8.0661 (3.1); 8.0612 (10.5); 8.0571 (1.6); 8.0526 (0.6); 7.7718 (1.6); 7.7677 (10.0); 7.7629 (3.4); 7.7512 (2.8); 7.7464 (9.0); 7.7421 (1.6); 6.9102 (0.6); 6.4739 (9.1); 6.4716 (9.0); 5.2872 (1.9); 5.2701 (3.1); 5.2530 (2.0); 4.0563 (1.1); 4.0385 (3.4); 4.0207 (3.4); 4.0029 (1.1); 3.3234 (13.8); 2.6715 (0.6); 2.5420 (1.2); 2.5253 (1.8); 2.5206 (2.4); 2.5119 (31.4); 2.5073 (68.9); 2.5027 (96.4); 2.4981 (66.0); 2.4935 (28.8); 2.4343 (24.1); 2.4321 (23.4); 2.3298 (0.6); 2.2684 (1.5); 2.1836 (0.7); 2.1328 (1.3); 2.1256 (1.2); 1.9893 (16.0); 1.9099 (4.4); 1.4453 (0.6); 1.4242 (11.4); 1.4071 (11.2); 1.3560 (6.4); 1.2588 (0.6); 1.2347 (0.8); 1.1927 (4.8); 1.1815 (0.8); 1.1749 (9.7); 1.1698 (0.5); 1.1572 (4.7); 0.8693 (1.2); 0.8521 (3.3); 0.8481 (2.5); 0.8457 (3.6); 0.8392 (1.1); 0.8280 (1.0); 0.8215 (1.2); 0.8183 (1.9); 0.8126 (0.6); 0.8074 (0.6); 0.7955 (0.6); 0.7923 (0.5); 0.7783 (0.7); 0.7595 (0.6); 0.7524 (1.2); 0.0079 (1.9); 0.0062 (0.5); 0.0053 (0.6); 0.0045 (0.8); -0.0002 (73.5); -0.0053 (0.8); -0.0061 (0.6); -0.0069 (0.6); -0.0085 (2.1) I.1-238: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3611 (1.1); 9.3446 (1.2); 8.7186 (2.9); 8.7125 (4.5); 8.6907 (5.4); 8.6846 (3.7); 8.0872 (0.6); 8.0829 (4.2); 8.0782 (1.3); 8.0665 (1.4); 8.0616 (5.0); 8.0575 (0.7); 7.7701 (0.7); 7.7660 (4.6); 7.7612 (1.4); 7.7495 (1.3); 7.7448 (4.1); 7.7405 (0.6); 5.3254 (0.9); 5.3085 (1.4); 5.2914 (0.9); 4.0557 (0.8); 4.0379 (2.6); 4.0202 (2.6); 4.0024 (0.8); 3.3204 (16.0); 2.6748 (0.8); 2.6666 (27.4); 2.5409 (1.5); 2.5241 (1.8); 2.5194 (2.4); 2.5107 (33.9); 2.5061 (74.2); 2.5015 (104.1); 2.4969 (71.4); 2.4924 (31.0); 2.3286 (0.6); 2.1322 (0.7); 2.1250 (0.7); 1.9887 (12.2); 1.9087 (2.9); 1.4478 (5.3); 1.4307 (5.3); 1.3552 (3.4); 1.1923 (3.7); 1.1746 (7.3); 1.1568 (3.6); 0.8696 (0.6); 0.8523 (1.7); 0.8482 (1.2); 0.8458 (1.8); 0.8394 (0.5); 0.8282 (0.6); 0.8218 (0.6); 0.8186 (0.9); 0.7527 (0.6); 0.0079 (2.3); 0.0063 (0.6); 0.0054 (0.7); 0.0046 (0.9); 0.0038 (1.2); -0.0002 (78.9); -0.0027 (3.2); -0.0043 (1.1); -0.0052 (0.8); -0.0060 (0.7); -0.0068 (0.6); -0.0085 (2.2) BCS241005-Foreign STR 155 I.1-240: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8418 (0.5); 8.7230 (1.2); 8.7169 (2.0); 8.6998 (2.4); 8.6937 (1.6); 8.1033 (1.8); 8.0985 (0.6); 8.0868 (0.6); 8.0820 (2.1); 7.7759 (2.0); 7.7712 (0.6); 7.7595 (0.6); 7.7547 (1.8); 5.3054 (0.6); 4.0377 (0.6); 4.0200 (0.6); 3.7408 (8.0); 3.3184 (16.0); 2.5405 (1.1); 2.5237 (1.3); 2.5190 (1.8); 2.5103 (26.8); 2.5057 (58.6); 2.5011 (82.0); 2.4965 (56.2); 2.4919 (24.4); 2.1116 (6.7); 1.9885 (3.0); 1.9084 (0.6); 1.4322 (2.3); 1.4152 (2.3); 1.3550 (0.9); 1.1922 (0.9); 1.1744 (1.9); 1.1566 (0.9); 0.0079 (1.3); 0.0046 (0.6); -0.0002 (41.8); -0.0027 (1.4); -0.0085 (1.1) I.1-242:1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1785 (1.5); 9.1736 (1.5); 8.7391 (1.0); 8.7330 (1.3); 8.7051 (1.6); 8.6990 (1.1); 8.2962 (1.5); 8.2912 (1.5); 8.1233 (1.3); 8.1021 (1.6); 7.8121 (1.5); 7.7909 (1.3); 3.9101 (5.8); 3.3198 (16.0); 2.5242 (0.6); 2.5195 (0.8); 2.5108 (11.9); 2.5063 (25.8); 2.5017 (35.8); 2.4971 (24.6); 2.4926 (10.8); 1.9890 (1.6); 1.4210 (1.8); 1.4041 (1.8); 1.1747 (0.9); 0.0080 (0.7); -0.0002 (24.9); -0.0085 (0.7) I.1-243: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7296 (0.8); 8.7235 (1.0); 8.6916 (1.2); 8.6855 (0.9); 8.2093 (2.4); 8.1053 (1.0); 8.0840 (1.2); 7.7915 (1.2); 7.7703 (1.0); 3.9053 (4.6); 3.3193 (16.0); 2.5241 (0.7); 2.5194 (0.9); 2.5106 (12.2); 2.5061 (26.1); 2.5015 (36.1); 2.4969 (24.7); 2.4923 (10.7); 1.9888 (1.5); 1.4202 (1.4); 1.4032 (1.4); 1.1746 (0.8); 0.0080 (0.8); -0.0002 (26.2); -0.0086 (0.7) I.1-244: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7059 (0.6); 8.6773 (0.7); 8.6712 (0.5); 8.3024 (1.2); 8.0781 (0.6); 8.0570 (0.7); 7.7752 (0.7); 7.7540 (0.6); 3.8971 (2.6); 3.3187 (16.0); 2.5238 (0.6); 2.5191 (0.9); 2.5103 (12.6); 2.5058 (27.1); 2.5012 (37.4); 2.4967 (25.7); 2.4921 (11.2); 1.4677 (0.8); 1.4505 (0.8); 0.0080 (0.8); -0.0002 (26.2); -0.0085 (0.7) I.1-245: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1786 (3.4); 9.1772 (3.3); 9.1503 (0.8); 9.1335 (0.8); 8.7053 (2.0); 8.6992 (2.8); 8.6703 (3.2); 8.6642 (2.4); 8.5362 (3.4); 8.5347 (3.3); 8.0867 (2.7); 8.0820 (0.8); 8.0703 (1.0); 8.0655 (3.2); 7.8059 (0.5); 7.8017 (3.1); 7.7969 (0.9); 7.7852 (0.9); 7.7805 (2.6); 5.2865 (0.6); 5.2695 (0.9); 5.2524 (0.6); 3.8979 (11.9); 3.3224 (16.0); 2.5251 (0.6); 2.5204 (0.8); 2.5117 (11.1); 2.5071 (24.0); 2.5025 (33.3); 2.4980 (22.8); 2.4934 (9.9); 1.4684 (3.5); 1.4512 (3.5); 0.0080 (0.7); -0.0002 (24.8); -0.0085 (0.7) I.1-246: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7245 (3.6); 8.1270 (1.3); 8.1060 (1.5); 7.7819 (1.4); 7.7609 (1.2); 7.3574 (1.0); 6.8977 (0.8); 6.8952 (0.8); 3.9087 (5.3); 3.3197 (16.0); 2.5242 (0.6); 2.5194 (0.9); 2.5106 (12.4); 2.5061 (26.2); 2.5016 (35.9); 2.4971 (24.8); 2.4926 (11.0); 2.4298 (3.2); 2.4277 (3.0); 1.3745 (1.8); 1.3577 (1.8); 0.0080 (0.7); -0.0002 (23.1); -0.0085 (0.7) BCS241005-Abroad STR 156 I.1-247: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7313 (2.1); 8.7290 (2.3); 8.1303 (1.2); 8.1091 (1.4); 7.8452 (1.3); 7.8314 (1.4); 7.7887 (1.4); 7.7675 (1.2); 7.3964 (1.0); 7.1306 (0.6); 7.1168 (0.6); 3.9097 (5.4); 3.3205 (16.0); 2.5197 (0.6); 2.5110 (8.7); 2.5064 (18.9); 2.5018 (26.3); 2.4972 (18.0); 2.4927 (7.8); 1.9890 (1.1); 1.3915 (1.6); 1.3748 (1.6); 1.1748 (0.6); 0.0080 (0.5); -0.0002 (19.5); -0.0085 (0.5) I.1-248: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7080 (1.0); 8.7019 (1.5); 8.6757 (1.6); 8.6696 (1.2); 8.1171 (1.5); 8.1007 (0.5); 8.0961 (1.7); 7.9121 (1.5); 7.9037 (1.6); 7.8239 (1.7); 7.8193 (0.5); 7.8029 (1.4); 7.6822 (1.5); 7.6738 (1.4); 5.2449 (0.5); 3.9035 (6.2); 3.3208 (16.0); 2.5194 (0.5); 2.5106 (8.7); 2.5061 (18.7); 2.5016 (25.8); 2.4970 (17.7); 2.4925 (7.8); 1.9889 (1.9); 1.4204 (2.0); 1.4034 (2.0); 1.1923 (0.5); 1.1746 (1.0); 1.1568 (0.5); -0.0002 (15.7) I.1-249: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7030 (0.6); 8.6969 (0.8); 8.6712 (0.9); 8.6651 (0.6); 8.1036 (0.8); 8.0827 (0.9); 7.8063 (1.7); 7.7861 (0.7); 3.9032 (3.5); 3.3209 (16.0); 2.5105 (7.0); 2.5060 (15.3); 2.5015 (21.3); 2.4969 (14.8); 2.4924 (6.7); 2.2832 (2.7); 1.9888 (1.4); 1.4174 (1.0); 1.4003 (1.0); 1.1746 (0.8); -0.0002 (12.7) I.1-251: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9939 (0.7); 8.9771 (0.7); 8.6931 (1.5); 8.6870 (2.1); 8.6624 (2.3); 8.6563 (1.6); 8.0859 (2.1); 8.0814 (0.6); 8.0694 (0.7); 8.0649 (2.5); 7.7935 (2.4); 7.7890 (0.7); 7.7770 (0.7); 7.7726 (2.0); 7.7143 (1.7); 7.7042 (1.8); 7.2558 (2.0); 7.2457 (1.9); 5.2284 (0.7); 3.8997 (8.6); 3.3207 (16.0); 2.5244 (0.7); 2.5197 (0.9); 2.5109 (13.1); 2.5064 (28.0); 2.5019 (38.6); 2.4973 (26.7); 2.4928 (11.7); 1.9890 (1.0); 1.4439 (2.7); 1.4267 (2.7); 1.1747 (0.5); 0.0080 (0.7); -0.0002 (22.8); -0.0085 (0.6) I.1-252: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0901 (1.2); 9.0735 (1.2); 8.7043 (2.1); 8.6983 (2.8); 8.6736 (3.0); 8.6676 (2.1); 8.0798 (3.2); 8.0594 (3.5); 7.9365 (4.7); 7.7733 (3.6); 7.7531 (3.1); 5.7578 (1.5); 5.2460 (0.8); 5.2291 (1.2); 5.2121 (0.8); 3.8981 (11.6); 3.3231 (16.0); 2.5075 (26.3); 2.5035 (32.9); 1.9900 (2.1); 1.4621 (4.5); 1.4449 (4.5); 1.1932 (0.6); 1.1754 (1.1); 1.1577 (0.5); -0.0002 (13.6) I.1-253: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0128 (1.4); 8.9958 (1.4); 8.6960 (2.3); 8.6916 (3.0); 8.6659 (3.0); 8.6641 (3.1); 8.6601 (2.3); 8.6581 (2.2); 8.0875 (3.6); 8.0678 (4.0); 7.7944 (4.0); 7.7746 (3.7); 7.7677 (2.8); 7.7573 (2.5); 7.1582 (2.5); 7.1563 (2.6); 7.1481 (2.5); 7.1461 (2.4); 5.2518 (0.9); 5.2347 (1.4); 5.2179 (0.9); 3.9015 (12.5); 3.3241 (15.9); 3.3222 (16.0); 2.5044 (46.5); 2.5030 (46.6); 1.9915 (0.9); 1.9896 (1.0); 1.4481 (5.3); 1.4309 (5.2); 1.1750 (0.5); 0.0020 (15.7); -0.0002 (16.6) BCS241005-Abroad STR 157 I.1-254: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6853 (0.5); 8.6791 (0.8); 8.6569 (0.9); 8.6508 (0.6); 8.0799 (0.7); 8.0586 (0.9); 7.7915 (0.8); 7.7702 (0.7); 7.7362 (0.6); 7.7264 (0.6); 7.0753 (0.7); 7.0655 (0.7); 3.8995 (3.2); 3.3193 (16.0); 2.5192 (0.6); 2.5104 (9.6); 2.5059 (21.0); 2.5013 (29.3); 2.4967 (20.1); 2.4921 (8.8); 1.9887 (0.9); 1.8595 (0.6); 1.8522 (0.6); 1.5197 (0.6); 1.5125 (0.6); 1.4390 (0.9); 1.4217 (0.8); 1.1745 (0.5); 0.0080 (0.8); -0.0002 (26.2); -0.0085 (0.7) I.1-255: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0371 (0.5); 8.6987 (1.1); 8.6926 (1.7); 8.6695 (1.8); 8.6634 (1.3); 8.0782 (1.6); 8.0618 (0.5); 8.0572 (1.8); 7.9039 (2.9); 7.7724 (1.8); 7.7677 (0.5); 7.7559 (0.5); 7.7514 (1.5); 5.7573 (1.1); 5.2153 (0.5); 3.8984 (6.5); 3.3210 (16.0); 2.5246 (0.6); 2.5200 (0.8); 2.5112 (10.4); 2.5067 (22.2); 2.5021 (30.7); 2.4975 (21.0); 2.4930 (9.1); 1.9892 (1.1); 1.4543 (2.0); 1.4371 (2.0); 1.1749 (0.6); 0.0080 (0.6); -0.0002 (19.4); -0.0085 (0.5) I.1-256: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6990 (0.6); 8.6928 (0.8); 8.6676 (0.9); 8.6615 (0.6); 8.0773 (0.8); 8.0560 (0.9); 7.8194 (0.9); 7.7981 (0.8); 3.8905 (3.3); 3.3213 (16.0); 2.5244 (0.6); 2.5197 (0.8); 2.5110 (6.2); 2.5065 (12.8); 2.5019 (17.5); 2.4973 (12.0); 2.4927 (5.3); 1.4976 (1.0); 1.4804 (0.9); -0.0002 (7.6) I.1-257:1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6940 (1.0); 8.6878 (1.5); 8.6667 (1.7); 8.6606 (1.2); 8.6572 (0.6); 8.6523 (0.9); 8.6476 (0.6); 8.2203 (0.5); 8.0679 (1.4); 8.0514 (0.5); 8.0468 (1.7); 7.8042 (1.6); 7.7831 (1.4); 7.7490 (0.6); 7.7290 (1.0); 7.7090 (0.5); 3.3357 (16.0); 2.5256 (0.8); 2.5209 (1.0); 2.5121 (12.5); 2.5076 (26.7); 2.5030 (36.6); 2.4985 (25.0); 2.4939 (10.8); 1.4950 (1.7); 1.4777 (1.7); - 0.0002 (15.6) I.1-258: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1275 (1.6); 9.0624 (2.3); 9.0460 (2.4); 8.6757 (4.1); 8.6696 (6.2); 8.6520 (6.5); 8.6459 (4.2); 8.3141 (4.9); 8.3090 (4.8); 8.0732 (6.0); 8.0524 (7.1); 7.9819 (4.5); 7.9614 (5.1); 7.7952 (6.8); 7.7744 (5.9); 7.5228 (2.6); 7.5178 (2.5); 7.5023 (2.4); 7.4972 (2.4); 5.2889 (1.4); 5.2719 (2.1); 5.2552 (1.4); 3.6012 (0.6); 3.3355 (16.0); 2.6722 (0.7); 2.5077 (89.7); 2.5033 (117.2); 2.4990 (84.6); 2.3305 (0.7); 1.7595 (0.7); 1.4443 (7.9); 1.4272 (7.8); 1.0909 (0.5); 0.0077 (3.8); -0.0002 (74.8); -0.0084 (3.2) I.1-259: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1294 (1.2); 9.0992 (2.1); 9.0828 (2.1); 8.6810 (3.7); 8.6749 (5.9); 8.6569 (6.2); 8.6508 (4.1); 8.2257 (2.8); 8.2220 (5.3); 8.2184 (3.2); 8.1340 (11.1); 8.1303 (10.5); 8.0727 (5.5); 8.0518 (6.7); 7.7876 (6.3); 7.7668 (5.6); 5.2870 (1.2); 5.2703 (1.9); 5.2533 (1.2); 3.3337 (16.0); 2.6762 (0.7); 2.6718 (1.0); 2.6671 (0.7); 2.5253 (2.8); 2.5116 (57.4); 2.5073 (119.1); 2.5029 (161.6); 2.4984 (116.4); 2.4942 (54.9); 2.3343 (0.7); 2.3301 (0.9); 2.3254 (0.7); 1.4499 (7.2); 1.4327 (7.1); 0.0079 (3.4); -0.0002 (90.1); -0.0084 (3.4) BCS241005-Abroad STR 158 I.1-260: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1303 (2.2); 9.1460 (3.0); 9.1295 (3.0); 8.6852 (4.8); 8.6792 (7.3); 8.6634 (7.5); 8.6574 (4.7); 8.0815 (7.2); 8.0609 (8.4); 8.0081 (5.6); 7.9878 (6.8); 7.8149 (14.0); 7.7944 (11.9); 5.3463 (1.8); 5.3295 (2.8); 5.3128 (1.8); 3.3416 (16.0); 2.5090 (59.4); 2.5050 (73.4); 2.5011 (54.8); 1.4734 (10.3); 1.4562 (10.1); -0.0002 (27.5) I.1-261: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6601 (2.7); 8.6541 (3.1); 8.5975 (3.1); 8.5928 (2.7); 8.2407 (4.0); 8.2207 (4.4); 8.0579 (0.6); 8.0008 (2.8); 7.9944 (3.0); 7.8404 (3.1); 7.7765 (4.6); 7.7558 (9.3); 7.5752 (3.1); 7.5187 (0.6); 7.4139 (1.0); 7.3937 (1.0); 7.2622 (80.2); 7.2603 (84.4); 6.9965 (0.6); 6.5034 (3.0); 5.7068 (1.1); 5.6904 (1.4); 5.6725 (1.0); 4.1315 (0.9); 4.1144 (1.0); 3.9745 (16.0); 2.8322 (0.8); 2.5836 (15.2); 2.0477 (3.9); 1.6731 (1.3); 1.4531 (6.8); 1.4359 (6.4); 1.2775 (1.4); 1.2597 (3.2); 1.2438 (1.2); 0.1473 (0.7); 0.0018 (117.6); -0.0002 (121.2); -0.1486 (0.6) I.1-262:1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2592 (0.8); 9.2429 (0.8); 8.6978 (1.8); 8.6917 (2.8); 8.6702 (3.2); 8.6642 (2.2); 8.4604 (2.1); 8.4552 (2.1); 8.0971 (1.1); 8.0918 (1.1); 8.0774 (2.9); 8.0763 (3.1); 8.0726 (1.1); 8.0707 (1.6); 8.0610 (0.9); 8.0562 (3.2); 7.8716 (2.4); 7.8505 (2.1); 7.8082 (2.9); 7.8034 (0.9); 7.7917 (0.8); 7.7869 (2.6); 5.3260 (0.5); 5.3091 (0.8); 5.2921 (0.5); 3.8938 (11.2); 3.3322 (16.0); 2.5251 (1.4); 2.5205 (1.8); 2.5116 (25.2); 2.5071 (55.4); 2.5025 (76.9); 2.4980 (52.8); 2.4934 (23.0); 1.9898 (2.2); 1.4853 (3.1); 1.4681 (3.1); 1.1922 (0.6); 1.1745 (1.3); 1.1567 (0.6); 0.0080 (2.2); - 0.0002 (76.0); -0.0068 (0.5); -0.0085 (2.0) I.1-263: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2663 (0.8); 9.2500 (0.8); 8.7034 (1.9); 8.6973 (2.9); 8.6753 (3.2); 8.6692 (2.2); 8.1374 (2.1); 8.1163 (2.6); 8.1020 (2.3); 8.0977 (2.3); 8.0855 (2.7); 8.0808 (0.8); 8.0689 (0.9); 8.0642 (3.3); 7.9355 (1.5); 7.9310 (1.3); 7.9145 (1.2); 7.9099 (1.2); 7.8105 (3.1); 7.8056 (0.9); 7.7939 (0.9); 7.7892 (2.7); 5.3267 (0.5); 5.3098 (0.8); 5.2928 (0.5); 3.8966 (11.6); 3.3336 (16.0); 2.5257 (0.9); 2.5210 (1.1); 2.5121 (16.3); 2.5076 (35.6); 2.5031 (49.4); 2.4985 (34.0); 2.4939 (14.8); 1.9901 (1.4); 1.4892 (3.2); 1.4720 (3.2); 1.1747 (0.8); 0.0080 (1.3); -0.0002 (48.6); -0.0085 (1.4) I.1-264: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2784 (4.1); 9.2620 (4.3); 8.6902 (8.8); 8.6841 (14.2); 8.6669 (16.0); 8.6608 (10.4); 8.4877 (10.7); 8.4825 (10.8); 8.1122 (5.6); 8.1069 (5.2); 8.0911 (6.6); 8.0858 (6.6); 8.0677 (12.6); 8.0631 (4.2); 8.0512 (4.6); 8.0465 (15.4); 7.8747 (12.1); 7.8536 (10.4); 7.7910 (14.1); 7.7864 (4.4); 7.7744 (4.2); 7.7699 (12.4); 5.3475 (0.5); 5.3314 (2.6); 5.3145 (4.0); 5.2977 (2.6); 5.2804 (0.5); 4.0553 (0.6); 4.0374 (1.7); 4.0196 (1.8); 4.0018 (0.5); 3.5936 (0.7); 3.5834 (0.9); 3.5020 (1.1); 3.3878 (0.5); 3.3336 (9.5); 2.6761 (1.4); 2.6716 (2.0); 2.6671 (1.5); 2.5408 (1.1); 2.5363 (1.6); 2.5316 (2.2); 2.5255 (6.1); 2.5207 (8.8); 2.5118 (119.3); 2.5073 (257.9); 2.5028 (355.2); 2.4982 (246.1); 2.4937 (107.8); 2.4810 (0.8); 2.4762 (0.5); 2.4715 (0.6); 2.4669 (0.5); 2.3344 (1.5); 2.3299 (2.1); 2.3252 (1.4); 2.2420 (0.8); 1.9899 (8.2); 1.9095 (5.3); 1.4813 (15.4); 1.4641 (15.4); BCS241005-Abroad STR 159 1.2981 (0.8); 1.2582 (1.3); 1.2334 (1.8); 1.1923 (2.4); 1.1746 (4.7); 1.1568 (2.3); 1.0258 (0.7); 1.0101 (0.6); 0.8542 (0.9); 0.8357 (0.5); 0.1456 (0.9); 0.0378 (0.5); 0.0286 (1.0); 0.0080 (7.9); -0.0002 (272.8); -0.0085 (7.2); -0.1495 (0.9) I.1-265: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1286 (0.7); 9.2834 (0.6); 9.2669 (0.6); 8.6960 (1.2); 8.6898 (1.9); 8.6719 (2.2); 8.6658 (1.4); 8.1412 (1.4); 8.1229 (1.7); 8.1197 (2.6); 8.0746 (1.8); 8.0700 (0.6); 8.0580 (0.8); 8.0535 (2.2); 7.9484 (1.0); 7.9438 (0.8); 7.9275 (0.8); 7.9228 (0.8); 7.7925 (2.0); 7.7760 (0.6); 7.7714 (1.7); 5.3146 (0.6); 3.3348 (16.0); 2.5255 (0.9); 2.5208 (1.2); 2.5120 (15.1); 2.5075 (32.2); 2.5030 (43.9); 2.4984 (30.1); 2.4939 (13.0); 1.4857 (2.1); 1.4684 (2.1); 0.0080 (1.1); - 0.0002 (36.0); -0.0085 (1.0) I.1-266: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9907 (0.7); 8.9742 (0.7); 8.6867 (1.6); 8.6806 (2.4); 8.6569 (2.6); 8.6509 (1.9); 8.0889 (2.2); 8.0843 (0.8); 8.0723 (0.8); 8.0677 (2.8); 7.8203 (2.6); 7.8156 (0.8); 7.8037 (0.8); 7.7991 (2.3); 7.4376 (1.1); 7.4334 (1.7); 7.4296 (1.2); 7.2820 (1.0); 7.2785 (1.1); 7.2761 (1.3); 7.2726 (1.1); 7.1670 (1.1); 7.1616 (1.5); 7.1565 (1.0); 5.2849 (0.7); 3.8984 (9.6); 3.7959 (10.7); 3.3333 (16.0); 2.5252 (0.8); 2.5206 (1.2); 2.5117 (16.7); 2.5072 (35.9); 2.5027 (49.2); 2.4982 (34.3); 2.4936 (15.2); 1.4597 (2.8); 1.4424 (2.8); 0.0080 (1.0); -0.0002 (33.1); -0.0085 (1.0) I.1-267: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6798 (0.7); 8.6562 (0.8); 8.6501 (0.6); 8.0884 (0.7); 8.0671 (0.8); 7.8186 (0.8); 7.7973 (0.7); 7.5670 (0.6); 3.8989 (2.8); 3.7898 (3.2); 3.3318 (16.0); 2.5246 (0.7); 2.5199 (1.0); 2.5111 (14.6); 2.5066 (31.6); 2.5020 (43.6); 2.4974 (29.9); 2.4929 (13.0); 1.4578 (0.8); 1.4405 (0.8); 0.0080 (1.0); -0.0002 (31.9); -0.0085 (0.9) I.1-268: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1246 (1.3); 9.0052 (1.4); 8.9888 (1.5); 8.6800 (2.6); 8.6739 (3.6); 8.6540 (3.9); 8.6480 (2.6); 8.0753 (3.7); 8.0546 (4.4); 7.8011 (4.2); 7.7805 (3.7); 7.4562 (3.0); 7.4524 (1.9); 7.2974 (1.9); 7.2923 (2.3); 7.2887 (1.8); 7.1692 (1.9); 7.1642 (2.8); 7.1590 (1.6); 5.3086 (0.9); 5.2918 (1.4); 5.2748 (0.9); 3.8193 (0.5); 3.7993 (16.0); 3.3362 (12.1); 2.5076 (48.9); 2.5033 (61.9); 2.4990 (44.5); 1.4579 (5.0); 1.4407 (5.1); -0.0002 (20.5); -0.0084 (1.2) I.1-269: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1251 (1.0); 9.0146 (1.5); 8.9983 (1.5); 8.6799 (2.6); 8.6739 (3.7); 8.6540 (3.9); 8.6480 (2.6); 8.0767 (3.8); 8.0562 (4.5); 7.8022 (4.3); 7.7816 (3.8); 7.5993 (2.2); 7.5960 (3.2); 7.5926 (2.0); 7.3279 (1.8); 7.3228 (2.5); 7.3194 (2.0); 7.2914 (2.2); 7.2867 (2.7); 7.2816 (1.5); 5.3067 (0.9); 5.2899 (1.4); 5.2730 (0.9); 3.7942 (16.0); 3.3383 (11.8); 2.5080 (37.8); 2.5038 (47.6); 2.4994 (34.4); 1.4564 (5.1); 1.4393 (5.1); -0.0002 (15.3); -0.0083 (0.9) I.1-270: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6756 (1.9); 8.6548 (1.2); 8.2316 (1.6); 8.1276 (1.4); 8.1083 (1.6); 7.7193 (0.7); 7.6879 (1.0); 7.6500 (0.6); 7.6314 (0.6); 7.5821 (1.0); 7.5412 (1.0); 7.3744 BCS241005-Foreign STR 160 (2.7); 7.2634 (13.6); 4.1492 (1.0); 4.1313 (2.9); 4.1135 (2.9); 4.0957 (1.0); 4.0652 (0.8); 3.9852 (16.0); 2.0477 (14.6); 1.5872 (7.9); 1.4429 (1.6); 1.4284 (1.8); 1.3921 (0.6); 1.3726 (0.6); 1.3346 (1.3); 1.2784 (3.4); 1.2605 (6.5); 1.2427 (3.3); 0.9544 (0.6); 0.9359 (1.2); 0.9175 (0.5); -0.0002 (16.9); -0.0084 (1.0) I.1-271: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6655 (2.0); 8.6430 (1.3); 8.2274 (1.8); 8.1224 (1.3); 8.1043 (1.5); 8.0782 (0.8); 8.0437 (1.1); 7.6630 (1.3); 7.6454 (1.3); 7.5271 (3.2); 7.5064 (2.4); 7.2632 (15.5); 7.1280 (0.5); 5.2051 (0.6); 4.1492 (0.8); 4.1314 (2.4); 4.1136 (2.4); 4.0957 (0.9); 4.0821 (0.6); 4.0653 (1.0); 4.0485 (0.6); 3.9832 (16.0); 2.0479 (12.9); 1.6106 (0.6); 1.5801 (11.4); 1.4373 (1.9); 1.4215 (2.0); 1.3915 (0.9); 1.3723 (0.8); 1.3544 (0.8); 1.3325 (1.4); 1.2785 (2.8); 1.2606 (5.4); 1.2428 (2.7); 0.9543 (0.8); 0.9360 (1.5); 0.9175 (0.7); -0.0002 (19.2) I.1-272:1H-NMR (400.6 MHz, CDCl3): δ= 8.6548 (2.6); 8.6488 (3.3); 8.6049 (2.8); 8.5988 (2.2); 8.2659 (3.4); 8.2540 (0.6); 8.2497 (3.1); 8.2450 (1.1); 8.2331 (1.1); 8.2285 (3.6); 8.2243 (0.6); 8.0270 (1.5); 7.7837 (3.4); 7.7790 (1.1); 7.7671 (1.1); 7.7625 (3.2); 7.3327 (0.6); 7.3122 (0.6); 7.2610 (26.7); 5.6494 (0.7); 5.6295 (0.6); 3.9773 (16.0); 1.8154 (0.8); 1.7985 (1.2); 1.7802 (1.5); 1.7617 (0.9); 1.5641 5 (5.5); 1.2651 (0.9); 0.8820 (1.6); 0.8643 (0.6); 0.7725 (2.6); 0.7540 (5.7); 0.7354 (2.4); 0.0079 (1.1); - 0.0002 (32.4); -0.0085 (1.0) I.1-274: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6986 (2.6); 8.6926 (3.2); 8.6459 (2.9); 8.6398 (2.3); 8.2522 (3.7); 8.2401 (0.6); 8.2358 (3.3); 8.2313 (1.1); 8.2194 (1.2); 8.2147 (3.6); 8.0224 (1.6); 7.7432 10 (3.6); 7.7387 (1.2); 7.7267 (1.1); 7.7222 (3.3); 7.6153 (0.6); 7.5962 (0.6); 7.2626 (20.0); 6.1370 (0.6); 6.1205 (1.0); 6.1013 (0.7); 5.9777 (0.6); 5.9617 (0.5); 5.9523 (0.7); 5.9356 (1.1); 5.9190 (0.6); 5.9096 (0.8); 5.8936 (0.6); 5.2627 (1.5); 5.2374 (1.4); 5.0457 (1.3); 5.0029 (1.2); 3.9806 (16.0); 1.6175 (1.0); 0.0080 (0.6); -0.0002 (17.0) 15 I.1-275: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6499 (2.9); 8.6440 (3.4); 8.6077 (3.4); 8.6018 (2.5); 8.2834 (5.4); 8.2595 (3.9); 8.2388 (4.2); 8.0386 (2.3); 7.8164 (4.2); 7.7957 (3.8); 7.2949 (1.0); 7.2624 (18.2); 5.6041 (1.0); 5.5844 (1.5); 5.5621 (1.1); 3.9778 (16.0); 2.0263 (0.6); 2.0095 (0.9); 1.9917 (0.9); 1.9744 (0.6); 1.5803 (9.6); 1.2637 (0.9); 0.8963 (6.7); 0.8796 (6.7); 0.8643 (0.7); 0.6207 (6.0); 0.6038 (5.9); -0.0002 (21.7); -0.0082 (1.2) 20 I.1-276: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6378 (2.2); 8.6318 (2.7); 8.5964 (2.7); 8.5905 (2.0); 8.2490 (3.1); 8.2283 (3.3); 7.8097 (3.4); 7.7891 (3.1); 7.7391 (2.4); 7.6070 (1.9); 7.3927 (1.8); 7.2640 (6.5); 7.1945 (0.9); 7.1718 (0.9); 5.5607 (0.9); 5.5410 (1.2); 5.5187 (0.9); 3.9737 (12.5); 2.1749 (16.0); 1.9734 (0.8); 1.9558 (0.8); 1.9384 (0.5); 1.6156 (0.6); 0.8720 (5.2); 0.8552 (5.0); 0.6067 (5.0); 0.589825 (4.8); -0.0002 (7.9) BCS241005-Abroad STR 161 I.1-277: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6317 (1.3); 8.6258 (1.6); 8.5961 (1.6); 8.5902 (1.2); 8.2457 (1.8); 8.2250 (2.0); 7.8072 (2.0); 7.7865 (1.8); 7.7085 (3.1); 7.7039 (3.0); 7.5153 (0.9); 7.5108 (1.4); 7.5063 (0.8); 7.2665 (2.4); 5.5462 (0.5); 5.5265 (0.7); 5.5040 (0.5); 3.9726 (7.7); 2.1745 (16.0); 1.6521 (1.0); 0.8704 (3.0); 0.8536 (3.0); 0.6000 (2.9); 0.5831 (2.9); -0.0002 (2.9) 5 I.1-278: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6763 (2.8); 8.6703 (3.2); 8.6247 (3.2); 8.6188 (2.6); 8.2208 (3.9); 8.2002 (4.2); 7.9075 (3.0); 7.9026 (2.9); 7.7362 (4.2); 7.7155 (3.8); 7.6570 (1.4); 7.6520 (1.2); 7.6363 (1.9); 7.6313 (1.7); 7.5340 (3.2); 7.5132 (2.3); 7.4662 (1.0); 7.4472 (1.1); 7.2619 (24.8); 6.1029 (0.8); 6.0868 (1.3); 6.0680 (0.9); 5.9446 (0.7); 5.9289 (0.6); 5.9190 (0.8); 5.9026 (1.2); 5.8862 (0.7); 5.8762 (0.8); 5.8606 (0.7); 5.2225 (1.9); 5.1975 (1.8); 5.0151 (1.8); 4.9725 (1.6); 3.9751 (16.0); 2.1748 (0.9); 1.5626 (1.3); 1.2641 (2.1); 0.8985 (1.0); 0.8820 (2.4); 0.8641 (1.1); -0.0002 (30.8) I.1-279: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6790 (2.7); 8.6730 (3.3); 8.6365 (3.3); 8.6305 (2.5); 8.2220 (3.7); 8.2012 (4.0); 8.0025 (2.0); 7.9989 (3.2); 7.9952 (1.8); 7.8433 (1.8); 7.8391 (2.8); 7.8350 15 (1.7); 7.7403 (2.2); 7.7360 (3.8); 7.7315 (5.4); 7.7103 (3.6); 7.4128 (0.9); 7.3935 (0.9); 7.2616 (45.6); 6.0831 (0.7); 6.0663 (1.2); 6.0476 (0.8); 5.9433 (0.7); 5.9278 (0.6); 5.9179 (0.8); 5.9012 (1.1); 5.8851 (0.7); 5.8752 (0.8); 5.8593 (0.7); 5.2294 (1.7); 5.2035 (1.6); 5.0191 (1.6); 4.9754 (1.5); 3.9754 (16.0); 1.5542 (3.4); 1.2642 (1.6); 0.8987 (0.7); 0.8820 (2.0); 0.8643 (0.9); -0.0002 (56.8); -0.0084 (3.2) 20 I.1-280: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6861 (2.8); 8.6802 (3.3); 8.6362 (3.3); 8.6303 (2.6); 8.2244 (3.9); 8.2039 (4.3); 7.7322 (4.3); 7.7115 (5.9); 7.5687 (2.3); 7.4930 (1.1); 7.4734 (1.2); 7.3781 (2.2); 7.2616 (37.7); 6.0961 (0.8); 6.0787 (1.4); 6.0607 (1.0); 5.9445 (0.7); 5.9287 (0.6); 5.9188 (0.8); 5.9022 (1.3); 5.8856 (0.7); 5.8761 (0.9); 5.8603 (0.7); 5.2343 (2.0); 5.2086 (1.9); 5.0216 (1.9); 4.9782 (1.7); 3.9767 (16.0); 1.5599 (1.9); 1.2639 (2.0); 0.8985 (0.9); 0.8818 (2.2); 0.8644 (1.0); -0.0002 (46.9) 25 I.1-281: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6797 (2.9); 8.6741 (3.3); 8.6365 (3.5); 8.6305 (2.5); 8.2219 (4.1); 8.2014 (4.4); 7.8623 (6.3); 7.8584 (6.7); 7.8020 (3.1); 7.7301 (4.4); 7.7097 (4.0); 7.4276 (1.2); 7.4080 (1.2); 7.2618 (28.6); 6.0848 (0.9); 6.0667 (1.5); 6.0482 (1.0); 5.9428 (0.7); 5.9271 (0.6); 5.9171 (0.8); 5.9003 (1.3); 5.8839 (0.7); 5.8739 (0.8); 5.8588 (0.7); 5.2288 (2.1); 5.2035 (2.0); 5.018930 (2.0); 4.9763 (1.8); 3.9756 (16.0); 1.5569 (2.7); 1.2633 (1.8); 0.8974 (0.8); 0.8816 (1.9); 0.8642 (0.9); - 0.0002 (35.4) I.1-282: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6350 (2.8); 8.6291 (3.3); 8.5867 (3.1); 8.5808 (2.4); 8.2364 (3.5); 8.2153 (4.0); 7.9251 (2.8); 7.9201 (2.8); 7.7790 (3.9); 7.7581 (3.6); 7.6709 (1.4); 7.6658 35 (1.2); 7.6501 (1.9); 7.6450 (1.7); 7.5441 (3.0); 7.5232 (2.3); 7.2621 (26.5); 7.1988 (0.9); 7.1783 (0.9); 5.6070 (1.0); 5.5887 (0.9); 3.9726 (16.0); 1.7756 (0.9); 1.7586 (1.0); 1.7501 (0.9); 1.7408 (0.8); 1.7315 (1.2); 1.7130 (0.9); 1.5657 (3.8); 0.7438 (3.0); 0.7253 (6.4); 0.7068 (2.9); -0.0002 (32.5); -0.0084 (1.7) BCS241005-Abroad STR 162 I.1-283: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6335 (2.8); 8.6276 (3.3); 8.5794 (3.2); 8.5734 (2.6); 8.2246 (3.8); 8.2040 (4.3); 7.9381 (3.0); 7.9331 (2.9); 7.8324 (4.3); 7.8118 (3.9); 7.6832 (1.4); 7.6782 (1.3); 7.6625 (1.9); 7.6574 (1.7); 7.5471 (3.2); 7.5264 (2.4); 7.2870 (1.1); 7.2625 (16.0); 5.1297 (1.1); 5 5.1087 (2.1); 5.0878 (1.2); 3.9697 (16.0); 1.5763 (1.3); 1.3027 (0.5); 1.2635 (2.2); 1.1385 (0.8); 1.1259 (0.7); 1.1182 (0.9); 1.1052 (0.5); 0.8982 (1.0); 0.8817 (2.6); 0.8640 (1.2); 0.5030 (0.6); 0.4981 (0.6); 0.4821 (0.8); 0.4741 (0.8); 0.3501 (0.7); 0.3296 (1.4); 0.3205 (2.0); 0.3073 (1.5); 0.2978 (0.7); -0.0002 (18.9); -0.0593 (0.6); -0.0698 (0.9); -0.0837 (1.1); -0.0963 (0.6) 10 I.1-285: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6458 (2.8); 8.6398 (3.4); 8.5983 (3.2); 8.5923 (2.6); 8.2402 (3.7); 8.2195 (4.1); 7.7741 (4.1); 7.7535 (3.7); 7.7275 (1.9); 7.7235 (3.0); 7.7196 (1.8); 7.5870 (2.0); 7.3837 (1.9); 7.2621 (24.2); 7.2290 (1.0); 7.2089 (1.0); 5.6065 (1.0); 5.5881 (0.9); 5.5695 (0.5); 3.9744 (16.0); 1.7836 (0.9); 1.7652 (1.0); 1.7589 (0.9); 1.7488 (0.9); 1.7403 (1.3); 1.7221 (1.0); 1.7053 (0.5); 1.5677 (1.4); 1.2639 (1.0); 0.8818 (1.2); 0.8643 (0.6); 0.7515 (3.1); 0.7330 (6.6); 0.7145 (3.0); - 15 0.0002 (29.4); -0.0080 (1.8) I.1-287: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6401 (3.0); 8.6368 (3.4); 8.5894 (3.5); 8.2271 (4.3); 8.2075 (4.7); 7.8232 (4.8); 7.8041 (4.4); 7.7395 (3.7); 7.5964 (3.1); 7.3869 (2.9); 7.2995 (1.6); 7.2781 (2.1); 7.2619 (30.0); 7.2599 (29.1); 5.1251 (1.4); 5.1049 (2.5); 5.0838 (1.3); 3.9714 (16.0); 1.5642 (4.1); 20 1.2639 (2.1); 1.1454 (1.1); 1.1251 (1.1); 0.8962 (0.9); 0.8819 (1.9); 0.8641 (1.0); 0.5172 (1.0); 0.4926 (1.2); 0.4736 (0.7); 0.3383 (2.2); 0.3261 (2.3); 0.3150 (1.9); 0.3016 (0.9); -0.0002 (37.4); -0.0022 (35.5); -0.0600 (1.0); -0.0724 (1.2); -0.0827 (1.4) I.1-288: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6455 (2.7); 8.6395 (3.3); 8.5939 (3.1); 8.5879 (2.5); 25 8.2404 (3.6); 8.2361 (1.3); 8.2195 (3.9); 7.7749 (3.9); 7.7705 (1.4); 7.7541 (3.6); 7.4930 (3.1); 7.4880 (2.9); 7.4740 (1.1); 7.4700 (1.1); 7.2620 (28.7); 7.2455 (1.2); 7.2247 (1.0); 7.1311 (0.9); 7.1097 (0.9); 5.6113 (0.9); 5.5931 (0.9); 3.9745 (16.0); 1.7817 (0.9); 1.7657 (0.9); 1.7540 (0.9); 1.7472 (0.8); 1.7357 (1.2); 1.7173 (0.9); 1.7010 (0.6); 1.5691 (1.2); 0.7501 (3.0); 0.7316 (6.3); 0.7130 (2.8); -0.0002 (35.0); - 0.0084 (1.8) 30 I.1-289: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6416 (2.9); 8.6357 (3.3); 8.5868 (3.2); 8.5808 (2.5); 8.2289 (3.6); 8.2081 (4.1); 7.8258 (4.0); 7.8050 (3.7); 7.5052 (3.2); 7.5001 (3.1); 7.4867 (1.2); 7.4816 (1.2); 7.3109 (0.9); 7.2919 (1.0); 7.2624 (16.2); 7.1348 (0.9); 7.1133 (1.0); 5.1374 (1.0); 5.1164 (1.9); 5.0955 (1.0); 3.9717 (16.0); 1.5790 (1.4); 1.1413 (0.8); 1.1337 (0.6); 1.1286 (0.6); 1.1207 (0.8); 0.511735 (0.5); 0.5052 (0.5); 0.4903 (0.8); 0.4855 (0.7); 0.4815 (0.7); 0.3552 (0.6); 0.3412 (1.1); 0.3347 (1.3); 0.3260 (1.8); 0.3154 (1.3); 0.3124 (1.3); 0.3033 (0.6); -0.0002 (19.7); -0.0083 (1.1); -0.0596 (0.5); -0.0715 (0.8); -0.0856 (0.9); -0.0982 (0.5) BCS241005-Abroad STR 163 I.1-290: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6499 (2.7); 8.6439 (3.3); 8.5994 (3.1); 8.5934 (2.5); 8.2406 (3.6); 8.2198 (4.0); 7.8766 (2.1); 7.8729 (3.2); 7.8692 (1.8); 7.7773 (4.0); 7.7564 (3.7); 7.6311 (2.0); 7.5334 (1.8); 7.2623 (18.9); 7.2513 (1.2); 7.2289 (1.0); 5.6014 (0.9); 5.5832 (0.9); 3.9741 (16.0); 5 1.7855 (1.0); 1.7663 (1.5); 1.7472 (1.5); 1.7290 (1.0); 1.7122 (0.6); 1.3033 (0.6); 1.2642 (2.6); 0.8986 (1.2); 0.8819 (3.3); 0.8642 (1.5); 0.7543 (3.0); 0.7358 (6.4); 0.7172 (2.9); -0.0002 (23.0); -0.0083 (1.2) I.1-291: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6434 (2.8); 8.6374 (3.4); 8.5921 (3.2); 8.5861 (2.6); 8.2283 (3.7); 8.2075 (4.1); 7.8911 (1.9); 7.8874 (3.0); 7.8837 (1.8); 7.8262 (4.1); 7.8054 (3.7); 7.6403 10 (2.0); 7.5380 (1.9); 7.3047 (0.9); 7.2849 (0.9); 7.2626 (13.3); 5.1183 (1.0); 5.0975 (1.9); 5.0766 (1.1); 3.9714 (16.0); 1.5846 (0.6); 1.2638 (1.2); 1.1485 (0.7); 1.1406 (0.5); 1.1359 (0.6); 1.1279 (0.8); 0.8986 (0.5); 0.8818 (1.5); 0.8642 (0.7); 0.5203 (0.5); 0.4985 (0.8); 0.4941 (0.7); 0.4888 (0.7); 0.3489 (0.7); 0.3388 (1.5); 0.3261 (1.4); 0.3155 (1.2); 0.3023 (0.7); -0.0002 (16.1); -0.0083 (1.0); -0.0590 (0.6); - 0.0705 (0.8); -0.0824 (0.9); -0.0926 (0.5) 15 I.1-294: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7139 (5.7); 8.6843 (2.2); 8.2618 (1.9); 8.1888 (1.4); 8.1213 (2.1); 7.7724 (2.3); 7.7476 (2.2); 7.6677 (1.3); 7.6484 (1.4); 7.6292 (1.7); 7.5925 (2.0); 7.5211 (1.9); 7.3974 (4.0); 7.2626 (39.8); 5.4229 (0.7); 5.3368 (0.9); 5.3023 (2.1); 3.7746 (6.2); 3.7589 (14.6); 3.7428 (6.7); 3.6616 (0.6); 2.1332 (3.8); 1.8942 (0.8); 1.8770 (6.1); 1.8686 (7.7); 1.8610 (16.0); 1.8525 20 (7.9); 1.8448 (6.3); 1.8279 (1.2); 1.5122 (3.2); 1.4960 (3.5); 1.4315 (1.6); 1.4130 (2.7); 1.4001 (2.7); 1.2560 (0.7); 0.9406 (0.5); -0.0002 (46.5) I.1-295: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7051 (3.8); 8.6767 (1.6); 8.2514 (1.3); 8.1713 (1.0); 8.1362 (1.6); 8.1038 (2.3); 8.0809 (1.0); 7.7458 (1.3); 7.7123 (0.9); 7.6607 (0.9); 7.6399 (0.8); 7.5525 25 (2.3); 7.5314 (2.2); 7.5013 (1.2); 7.2629 (26.2); 5.3567 (0.6); 5.3022 (4.3); 3.7745 (5.9); 3.7584 (14.4); 3.7422 (6.2); 2.1299 (2.8); 1.8937 (0.7); 1.8769 (6.0); 1.8689 (7.4); 1.8607 (16.0); 1.8522 (7.2); 1.8444 (6.0); 1.8273 (1.0); 1.5122 (2.2); 1.4957 (2.4); 1.4323 (1.4); 1.4200 (1.9); 1.4039 (1.8); -0.0002 (31.2); - 0.0082 (1.9) 30 I.1-296: 1H-NMR (400.6 MHz, CDCl3): δ= 9.3019 (0.6); 9.2846 (0.6); 8.7160 (1.0); 8.7100 (1.6); 8.6936 (1.7); 8.6876 (1.0); 8.1569 (1.3); 8.1520 (1.2); 8.0888 (1.6); 8.0681 (1.8); 7.8356 (1.0); 7.8147 (1.4); 7.7859 (1.8); 7.7653 (1.6); 7.7143 (0.8); 7.7092 (0.7); 7.6934 (0.6); 7.6884 (0.6); 6.1336 (0.5); 5.8628 (0.6); 5.2150 (0.7); 5.1894 (0.7); 4.9703 (0.7); 4.9273 (0.6); 3.9006 (5.8); 3.3340 (16.0); 2.5073 (27.5); 2.5030 (35.3); 2.4986 (25.4); 2.4944 (12.6); -0.0002 (12.0); -0.0083 (0.7) 35 BCS241005-Abroad STR 164 I.1-297: 1H-NMR (400.6 MHz, d6-DMSO): δ= 9.0595 (0.8); 9.0442 (0.8); 8.7244 (1.8); 8.6875 (1.2); 8.6818 (1.8); 8.1326 (1.7); 8.1159 (1.8); 7.8280 (2.0); 7.8110 (1.7); 7.7789 (1.0); 7.7589 (1.0); 7.3282 (0.5); 7.3083 (1.0); 7.2892 (0.6); 7.1707 (1.1); 7.1519 (0.9); 5.2457 (0.7); 3.9677 (0.5); 3.9105 (5.0); 3.9069 (5.4); 3.3903 (1.6); 3.3325 (15.3); 3.3288 (16.0); 2.5578 (9.0); 2.5017 (70.2); 2.4977 (72.8); 5 1.4403 (2.6); 1.4238 (2.4); 0.0568 (0.9); -0.0002 (9.2); -0.0042 (9.1) I.1-298: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1565 (2.2); 9.0641 (2.1); 9.0468 (2.2); 8.7250 (4.0); 8.7190 (5.1); 8.6854 (5.4); 8.6794 (4.2); 8.1151 (5.6); 8.0945 (6.5); 7.8045 (6.3); 7.7840 (8.0); 7.7640 (3.0); 7.7604 (2.7); 7.3334 (2.0); 7.3142 (4.0); 7.2946 (2.4); 7.1797 (2.8); 7.1760 (2.7); 7.1609 (2.4); 10 7.1573 (2.1); 5.2784 (1.3); 5.2612 (2.1); 5.2442 (1.4); 3.3439 (16.0); 2.5078 (45.9); 2.5035 (58.6); 2.4992 (42.2); 1.4459 (7.6); 1.4290 (7.7); -0.0002 (11.2); -0.0083 (0.6) I.1-299: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1303 (2.9); 9.1450 (3.6); 9.1300 (3.8); 8.6797 (7.4); 8.6633 (7.2); 8.0807 (7.3); 8.0617 (8.7); 8.0073 (7.1); 7.9879 (8.3); 7.8145 (16.0); 7.7951 (14.6); 5.3453 15 (2.2); 5.3294 (3.2); 5.3128 (2.4); 3.3416 (12.4); 2.6738 (0.7); 2.5052 (83.7); 2.3328 (1.0); 1.4725 (11.4); 1.4568 (11.5); 1.2425 (6.2); 0.8571 (4.3); 0.8404 (2.4); -0.0002 (5.1) I.1-300: 1H-NMR (400.6 MHz, d6-DMSO): δ= 9.0703 (0.6); 9.0533 (0.5); 8.7341 (1.0); 8.7284 (1.1); 8.6895 (1.2); 8.6837 (0.9); 8.1316 (1.4); 8.1113 (1.6); 7.8311 (1.5); 7.8107 (1.4); 7.5417 (1.5); 7.5275 20 (0.9); 7.5218 (0.8); 7.2551 (1.1); 7.2496 (1.0); 5.2864 (0.5); 3.9089 (4.9); 3.3326 (16.0); 2.5053 (40.3); 2.5019 (49.7); 1.4565 (2.0); 1.4396 (2.0); -0.0002 (9.8) I.1-301: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1464 (0.9); 9.0805 (0.7); 9.0632 (0.8); 8.7296 (1.6); 8.7235 (1.9); 8.6871 (2.1); 8.6810 (1.7); 8.1104 (2.0); 8.0893 (2.3); 7.8046 (2.3); 7.7835 (2.0); 7.5673 25 (0.7); 7.5461 (2.4); 7.5310 (1.6); 7.5253 (1.5); 7.5097 (0.5); 7.5040 (0.6); 7.2957 (1.7); 7.2901 (1.6); 5.2866 (0.7); 5.2693 (0.5); 3.3382 (16.0); 2.5115 (19.6); 2.5072 (37.4); 2.5027 (48.2); 2.4982 (35.6); 2.4939 (19.1); 1.4539 (2.6); 1.4369 (2.7); -0.0002 (9.0); -0.0085 (0.7) I.1-302: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6569 (2.7); 8.6509 (3.2); 8.6033 (3.1); 8.5973 (2.5); 30 8.2327 (3.7); 8.2120 (4.0); 7.7876 (11.4); 7.7313 (4.0); 7.7106 (3.7); 7.3260 (0.8); 7.3062 (0.9); 7.2624 (16.0); 5.6514 (0.9); 5.6340 (1.1); 5.6153 (0.9); 3.9749 (16.0); 1.5730 (11.3); 1.4086 (6.1); 1.3919 (6.2); -0.0002 (19.8); -0.0083 (1.1) I.1-303: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1964 (1.7); 9.1803 (1.8); 8.6607 (2.6); 8.6551 (4.6); 35 8.6464 (4.7); 8.6405 (2.3); 8.0330 (4.3); 8.0123 (16.0); 7.6966 (4.2); 7.6764 (3.8); 5.3359 (1.0); 5.3191 (1.6); 5.3025 (1.0); 2.5079 (55.0); 2.5042 (65.0); 2.3311 (0.6); 1.4585 (5.7); 1.4414 (5.8); -0.0002 (27.6) BCS241005-Abroad STR 165 I.1-304: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6327 (2.5); 8.6267 (3.5); 8.6047 (3.3); 8.5987 (2.2); 8.2279 (3.6); 8.2235 (1.3); 8.2111 (1.7); 8.2071 (3.9); 7.8289 (0.5); 7.8048 (0.8); 7.8006 (0.9); 7.7964 (0.6); 7.7846 (1.2); 7.7805 (1.2); 7.7765 (0.6); 7.7686 (0.6); 7.7644 (0.8); 7.7602 (0.6); 7.7470 (4.1); 7.7426 (1.5); 7.7262 (3.6); 7.3221 (0.7); 7.3181 (0.9); 7.3025 (0.6); 7.2982 (1.0); 7.2941 (0.7); 7.2785 (0.5); 7.2740 (0.5); 7.2640 (6.1); 7.2061 (0.5); 7.2026 (0.5); 7.1942 (0.6); 7.1908 (0.6); 7.1859 (0.8); 7.1824 (0.8); 7.1741 (0.8); 7.1708 (0.8); 5.7139 (0.5); 5.7095 (0.6); 5.6931 (0.8); 5.6785 (0.6); 5.3016 (1.4); 3.9721 (16.0); 1.5962 (3.2); 1.4401 (6.3); 1.4234 (6.4); -0.0002 (7.5) I.1-305: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6471 (2.8); 8.6412 (3.2); 8.5890 (3.1); 8.5831 (2.6); 10 8.2302 (3.8); 8.2095 (4.1); 7.7408 (4.1); 7.7201 (3.8); 7.6355 (1.4); 7.6309 (1.4); 7.6120 (1.4); 7.6074 (1.5); 7.5517 (1.0); 7.5471 (0.9); 7.5307 (1.9); 7.5262 (1.7); 7.4946 (1.8); 7.4772 (1.9); 7.4567 (1.0); 7.3575 (0.9); 7.3380 (0.9); 7.2638 (6.3); 5.6742 (0.9); 5.6566 (1.2); 5.6383 (0.9); 3.9732 (16.0); 1.6134 (3.2); 1.4053 (6.4); 1.3886 (6.4); -0.0002 (7.7) I.1-306: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.5061 (1.2); 9.4897 (1.2); 8.8287 (1.6); 8.8238 (2.3); 8.8196 (1.7); 8.7237 (1.8); 8.7198 (2.6); 8.7145 (2.5); 8.7121 (3.0); 8.7059 (3.6); 8.7002 (2.4); 8.6965 (3.1); 8.6792 (3.4); 8.6731 (2.5); 8.0703 (3.2); 8.0494 (3.9); 7.8164 (3.7); 7.7955 (3.2); 5.3916 (0.8); 5.3747 (1.1); 5.3579 (0.8); 3.8854 (12.4); 3.3346 (16.0); 2.7120 (13.1); 2.5077 (35.3); 2.5033 (45.2); 2.4989 (33.1); 1.9902 (1.0); 1.5314 (4.3); 1.5143 (4.3); 1.1748 (0.6); -0.0002 (11.4); -0.0084 (0.7) I.1-307: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1124 (0.8); 9.5247 (0.5); 9.5082 (0.6); 8.8556 (0.7); 8.8510 (1.1); 8.8466 (0.7); 8.7199 (1.8); 8.7158 (2.2); 8.7044 (1.2); 8.6983 (1.5); 8.6762 (1.5); 8.6702 (1.1); 8.0594 (1.4); 8.0387 (1.6); 7.8001 (1.6); 7.7794 (1.4); 5.3788 (0.5); 3.3328 (16.0); 2.7139 (5.6); 2.6713 (0.6); 2.5105 (39.6); 2.5066 (74.1); 2.5022 (94.4); 2.4978 (67.7); 2.4937 (33.6); 2.3292 (0.7); 1.5275 (1.8); 1.5101 (1.9); -0.0002 (39.8); - 0.0083 (2.4) I.1-308: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7101 (0.6); 8.6941 (0.6); 8.0881 (0.6); 8.0675 (0.7); 8.0209 (0.5); 7.8322 (0.5); 7.7861 (0.7); 7.7654 (0.6); 3.8992 (2.3); 3.3341 (16.0); 2.5069 (20.2); 2.5025 (25.7); 2.4982 (18.5); -0.0002 (4.3) I.1-309: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1416 (3.2); 9.3135 (6.1); 9.2952 (6.1); 8.7053 (13.8); 8.6870 (13.2); 8.0704 (13.7); 8.0539 (16.0); 8.0391 (14.9); 7.8559 (7.3); 7.8351 (9.0); 7.7631 (14.8); 7.7460 (13.3); 7.6921 (8.2); 7.6711 (6.3); 6.1477 (2.5); 6.1246 (3.8); 6.1063 (2.8); 6.0814 (2.1); 5.8838 (3.7); 5.8696 (6.8); 5.8526 (3.3); 5.2150 (7.0); BCS241005-Abroad STR 166 5.1892 (6.5); 4.9624 (6.9); 4.9194 (6.0); 3.4110 (10.5); 2.6715 (11.1); 2.5022 (847.6); 2.4984 (832.3); 2.3295 (9.9); 0.1413 (2.0); -0.0002 (208.5); -0.0044 (203.9) I.1-310: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1369 (2.9); 9.0542 (4.8); 9.0382 (4.9); 8.6823 (7.9); 8.6770 (10.0); 8.6590 (10.6); 8.6543 (7.1); 8.0733 (10.8); 8.0531 (12.3); 7.8336 (5.4); 7.7988 (13.4); 7.7785 (11.0); 7.7092 (2.1); 7.6870 (14.6); 7.6711 (6.2); 7.6502 (2.0); 5.3178 (2.9); 5.3013 (4.3); 5.2846 (3.0); 5.2665 (0.9); 3.3429 (5.5); 2.6748 (0.6); 2.5061 (94.4); 2.3331 (1.0); 1.4655 (16.0); 1.4485 (15.9); -0.0002 (30.1) I.1-311: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6339 (2.6); 8.6280 (3.3); 8.5948 (3.2); 8.5888 (2.4); 8.2284 (3.7); 8.2075 (4.1); 8.1663 (2.3); 8.1478 (2.3); 7.8453 (0.5); 7.8372 (0.5); 7.7312 (4.0); 7.7103 (3.7); 7.3162 (2.4); 7.2892 (2.4); 7.2638 (6.8); 5.6802 (0.5); 5.6759 (0.6); 5.6591 (0.8); 5.6450 (0.6); 3.9734 (16.0); 1.5903 (3.5); 1.4287 (6.3); 1.4120 (6.3); -0.0002 (7.8) I.1-312: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.2028 (0.5); 8.9928 (4.2); 8.9762 (4.1); 8.7193 (7.3); 8.7161 (9.0); 8.6901 (8.9); 8.6876 (8.9); 8.6844 (6.9); 8.0975 (10.4); 8.0788 (11.7); 7.7875 (11.3); 7.7684 (10.3); 7.5599 (1.3); 7.5442 (2.1); 7.5363 (2.5); 7.5191 (2.6); 7.5012 (1.0); 7.2753 (1.8); 7.2527 (8.0); 7.2442 (5.9); 7.2262 (2.9); 7.2064 (0.8); 5.3276 (0.9); 5.3112 (3.0); 5.2944 (4.2); 5.2779 (2.8); 5.2617 (0.7); 3.3447 (1.5); 2.6701 (1.6); 2.5048 (87.9); 2.5017 (83.6); 1.4352 (16.0); 1.4185 (15.3); -0.0002 (15.9); -0.0028 (14.5) I.1-313: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1539 (2.9); 9.0129 (4.3); 8.9963 (4.1); 8.7275 (7.4); 8.7245 (8.7); 8.6943 (8.9); 8.0960 (10.9); 8.0777 (11.5); 7.8755 (1.0); 7.8604 (1.0); 7.8344 (1.2); 7.7923 (8.1); 7.7813 (12.8); 7.7678 (10.1); 7.7631 (11.0); 7.6563 (6.4); 7.6399 (6.2); 5.3270 (1.0); 5.3100 (2.9); 5.2932 (4.2); 5.2763 (2.7); 5.2589 (0.7); 3.3413 (14.0); 2.6729 (1.9); 2.5083 (101.9); 2.5046 (99.8); 2.3310 (0.6); 1.4406 (16.0); 1.4237 (15.3); 1.3570 (2.2); 1.2732 (0.7); 1.2359 (0.6); 1.1829 (1.8); 1.1725 (1.8); 0.0032 (16.4); -0.0002 (17.7) I.1-314: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6380 (2.5); 8.6321 (3.5); 8.6110 (3.5); 8.6051 (2.3); 8.2255 (3.8); 8.2048 (4.2); 7.9242 (1.3); 7.9034 (2.1); 7.8833 (1.8); 7.8655 (0.7); 7.7338 (4.1); 7.7131 (3.9); 7.3849 (1.7); 7.3814 (1.6); 7.3632 (1.6); 7.3598 (1.5); 7.2635 (7.6); 5.6965 (0.6); 5.6919 (0.6); 5.6779 (0.9); 5.6612 (0.7); 5.3017 (0.7); 3.9719 (16.0); 1.5844 (4.8); 1.4328 (6.5); 1.4161 (6.5); -0.0002 (8.4) BCS241005-Abroad STR 167 I.1-315: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6581 (2.0); 8.6522 (2.3); 8.6008 (2.3); 8.5949 (1.8); 8.2330 (2.7); 8.2122 (3.0); 7.7301 (3.0); 7.7146 (3.0); 7.7100 (3.5); 7.5474 (1.2); 7.5427 (1.0); 7.5256 (1.2); 7.5209 (1.1); 7.3463 (0.6); 7.3272 (0.7); 7.2620 (21.1); 5.6560 (0.7); 5.6382 (0.9); 5.6201 (0.7); 3.9753 (11.6); 1.5625 (16.0); 1.4056 (4.6); 1.3889 (4.6); -0.0002 (23.3); -0.0083 (1.3) I.1-318: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6850 (7.9); 8.6790 (9.0); 8.6284 (8.9); 8.6225 (7.2); 8.4437 (7.9); 8.2739 (4.2); 8.2543 (4.5); 8.0849 (3.9); 8.0657 (4.2); 7.7756 (8.5); 7.7245 (3.8); 7.7051 (6.6); 7.6857 (3.3); 7.6289 (6.4); 7.4981 (3.9); 7.4755 (4.0); 7.3657 (6.0); 7.2630 (20.7); 5.5406 (2.8); 5.5198 (4.6); 5.4985 (2.8); 3.7775 (0.8); 3.7613 (2.0); 3.7452 (0.9); 2.1366 (0.8); 2.1100 (0.5); 2.0924 (1.4); 2.0754 (2.3); 2.0576 (2.4); 2.0402 (1.6); 2.0228 (0.7); 1.8779 (0.8); 1.8693 (1.0); 1.8615 (2.2); 1.8532 (1.0); 1.8453 (0.9); 1.2401 (0.7); 0.9286 (16.0); 0.9119 (15.9); 0.6517 (15.2); 0.6349 (15.1); -0.0002 (22.6) I.1-319: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6773 (7.2); 8.6712 (8.4); 8.6179 (8.2); 8.6119 (6.8); 8.4003 (7.0); 8.2611 (3.6); 8.2416 (4.0); 8.0185 (3.2); 7.9992 (3.7); 7.7456 (4.9); 7.7419 (7.6); 7.7380 (4.6); 7.7113 (3.4); 7.6918 (6.1); 7.6725 (3.0); 7.5957 (5.4); 7.4295 (2.9); 7.4085 (3.2); 7.3642 (5.2); 7.2624 (56.8); 5.6189 (1.1); 5.5999 (2.6); 5.5838 (2.6); 5.5639 (1.3); 3.7724 (2.3); 3.7561 (6.3); 3.7400 (2.9); 3.7110 (1.7); 2.1296 (5.3); 1.9046 (0.6); 1.8886 (1.1); 1.8750 (3.2); 1.8684 (4.4); 1.8589 (8.4); 1.8512 (5.5); 1.8421 (4.6); 1.8217 (3.6); 1.8033 (2.7); 1.7865 (1.7); 1.7682 (1.1); 1.2559 (0.6); 1.2423 (0.8); 1.2221 (0.6); 0.8101 (7.1); 0.7917 (16.0); 0.7732 (7.6); -0.0002 (61.4) I.1-320: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6705 (12.9); 8.6646 (15.3); 8.6162 (15.2); 8.6101 (12.5); 8.4500 (11.9); 8.4001 (1.4); 8.2510 (6.3); 8.2313 (6.9); 8.0576 (5.7); 8.0385 (6.4); 8.0122 (1.0); 7.9934 (1.0); 7.7485 (13.2); 7.6953 (5.9); 7.6759 (10.6); 7.6566 (5.2); 7.5971 (10.1); 7.5206 (1.0); 7.4748 (5.2); 7.4554 (5.4); 7.3669 (10.6); 7.2621 (153.0); 6.9984 (0.8); 5.1164 (4.4); 5.0956 (8.1); 5.0749 (4.7); 3.9546 (0.7); 3.7708 (5.5); 3.7545 (13.5); 3.7385 (6.0); 2.1271 (15.4); 1.8743 (6.1); 1.8668 (7.6); 1.8581 (16.0); 1.8500 (7.8); 1.8421 (6.5); 1.4327 (3.6); 1.2546 (2.8); 1.2423 (4.4); 1.2332 (3.2); 1.2219 (4.2); 1.2094 (2.6); 1.2010 (1.9); 0.9584 (0.6); 0.9400 (1.2); 0.8057 (1.6); 0.7877 (3.1); 0.7690 (1.4); 0.5747 (1.0); 0.5532 (2.5); 0.5413 (3.5); 0.5270 (2.9); 0.5067 (1.6); 0.4407 (1.3); 0.4267 (2.4); 0.4147 (2.6); 0.4062 (3.5); 0.3940 (3.4); 0.3715 (2.6); 0.3573 (3.3); 0.3465 (3.9); 0.3344 (4.2); 0.3220 (3.1); 0.1459 (0.8); 0.0666 (1.3); 0.0552 (2.9); 0.0407 (3.6); 0.0308 (4.0); 0.0174 (3.3); -0.0002 (165.6); -0.1495 (0.9) BCS241005-Abroad STR 168 I.1-321: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6792 (7.0); 8.6746 (7.7); 8.6124 (7.7); 8.6068 (6.6); 8.2563 (9.8); 8.2363 (10.8); 7.7696 (10.5); 7.7496 (9.9); 7.6476 (4.8); 7.6264 (6.5); 7.6175 (9.8); 7.5539 (3.7); 7.5344 (3.8); 7.2640 (39.6); 7.1403 (6.6); 7.1198 (6.2); 5.7735 (0.7); 5.7553 (2.4); 5.7374 (3.6); 5.7200 (2.5); 5.7041 (0.8); 3.7725 (2.1); 3.7574 (4.9); 3.7414 (2.4); 2.1349 (1.6); 1.8760 (2.0); 1.8676 (2.9); 1.8593 (5.3); 1.8520 (3.0); 1.8443 (2.3); 1.4804 (15.5); 1.4638 (16.0); 1.4332 (2.0); 1.2560 (1.0); -0.0002 (43.1) I.1-322: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6381 (2.8); 8.6321 (3.3); 8.5871 (3.1); 8.5811 (2.5); 8.2461 (3.6); 8.2253 (4.0); 8.1765 (1.0); 8.1716 (1.0); 7.9500 (2.9); 7.9449 (2.9); 7.9276 (0.6); 7.9227 (0.6); 7.9067 (0.6); 7.9018 (0.6); 7.8235 (4.0); 7.8027 (3.6); 7.6932 (1.4); 7.6881 (1.3); 7.6724 (1.9); 7.6673 (1.7); 7.5754 (1.0); 7.5533 (3.6); 7.5323 (2.4); 7.2625 (18.2); 7.2277 (1.0); 7.2041 (1.0); 5.5539 (1.0); 5.5343 (1.4); 5.5118 (1.0); 3.9712 (16.0); 3.9484 (0.5); 1.9895 (0.5); 1.9724 (0.9); 1.9550 (0.9); 1.9371 (0.6); 1.2631 (2.2); 0.8986 (1.1); 0.8818 (3.3); 0.8734 (6.4); 0.8640 (2.3); 0.8567 (6.1); 0.5994 (5.7); 0.5825 (5.7); -0.0002 (22.0); -0.0084 (1.2) I.1-323: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6440 (1.6); 8.6380 (1.9); 8.5939 (1.8); 8.5880 (1.4); 8.2502 (2.1); 8.2296 (2.4); 7.8187 (2.3); 7.7981 (2.1); 7.5182 (1.9); 7.5131 (1.5); 7.4978 (0.6); 7.4931 (0.7); 7.2685 (2.1); 7.2619 (0.6); 7.2390 (0.6); 7.1373 (0.5); 7.1161 (0.6); 5.5626 (0.6); 5.5432 (0.8); 5.5208 (0.6); 3.9736 (8.9); 2.1758 (16.0); 1.9768 (0.5); 1.9594 (0.5); 0.8743 (3.5); 0.8575 (3.4); 0.6079 (3.3); 0.5911 (3.3); -0.0002 (2.3) I.1-324: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6190 (2.7); 8.6131 (3.5); 8.5897 (3.4); 8.5837 (2.3); 8.2438 (3.7); 8.2230 (4.1); 7.8236 (4.1); 7.8028 (3.7); 7.4974 (2.0); 7.4940 (3.1); 7.3439 (1.9); 7.3386 (2.3); 7.3350 (1.8); 7.2642 (7.1); 7.2041 (1.9); 7.1988 (2.5); 7.1943 (1.6); 7.1343 (1.0); 7.1112 (1.1); 5.5460 (1.0); 5.5263 (1.4); 5.5037 (1.0); 5.3017 (5.2); 3.9694 (15.7); 3.8531 (16.0); 2.1742 (0.6); 1.9808 (0.5); 1.9638 (0.9); 1.9460 (0.9); 1.9287 (0.6); 1.6147 (5.0); 1.2564 (0.5); 0.8730 (6.2); 0.8562 (6.0); 0.5941 (5.9); 0.5772 (5.8); -0.0002 (7.8) I.1-325: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6141 (2.8); 8.6081 (3.4); 8.5704 (3.2); 8.5644 (2.5); 8.2593 (3.6); 8.2550 (1.3); 8.2426 (1.7); 8.2385 (4.0); 7.8470 (4.0); 7.8426 (1.4); 7.8261 (3.5); 7.7325 (1.8); 7.7286 (2.8); 7.7246 (1.7); 7.5964 (1.9); 7.3912 (1.8); 7.2627 (14.2); 7.1130 (0.8); 7.0914 (0.9); 5.7327 (1.0); 5.7111 (1.9); 5.6894 (1.0); 5.3021 (7.8); 3.9798 (16.0); 2.5874 (0.8); 2.5672 (0.8); 1.8659 (0.7); 1.8588 (0.8); 1.8437 (1.1); 1.8223 (1.0); 1.8010 (0.5); 1.7166 (0.6); 1.7109 (0.6); 1.6888 (0.7); 1.6248 (0.6); 1.6149 (0.9); 1.6064 (1.1); 1.5969 (1.1); 1.5821 (10.2); 1.4166 (0.7); 1.3933 (0.8); -0.0002 (16.8); -0.0083 (0.9) BCS241005-Abroad STR 169 I.1-326: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6285 (2.8); 8.6226 (3.4); 8.5820 (3.3); 8.5761 (2.6); 8.2755 (6.1); 8.2714 (5.8); 8.2499 (4.3); 8.0339 (2.3); 7.8599 (4.2); 7.8391 (3.7); 7.2639 (6.6); 7.2420 (1.0); 7.2203 (1.0); 5.7822 (1.0); 5.7604 (2.0); 5.7386 (1.0); 5.3020 (7.4); 3.9841 (16.0); 2.6250 (0.9); 2.6046 (0.9); 1.9107 (0.6); 1.8997 (0.7); 1.8909 (0.8); 1.8817 (0.8); 1.8710 (0.6); 1.8609 (1.1); 1.8391 (1.0); 1.8176 (0.6); 1.8118 (0.5); 1.7301 (0.6); 1.7255 (0.7); 1.7029 (0.8); 1.6817 (0.5); 1.6337 (2.5); 1.6191 (1.4); 1.6097 (1.2); 1.5986 (1.3); 1.5906 (0.9); 1.5794 (0.6); 1.4218 (0.8); 1.3980 (0.8); 1.3718 (0.5); -0.0002 (7.9) I.1-327: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6048 (2.8); 8.5989 (3.4); 8.5583 (3.2); 8.5524 (2.5); 8.2555 (3.6); 8.2348 (4.2); 7.9356 (2.9); 7.9306 (2.9); 7.8546 (4.0); 7.8339 (3.8); 7.6802 (1.4); 7.6751 (1.3); 7.6594 (1.9); 7.6543 (1.8); 7.5514 (3.1); 7.5307 (2.3); 7.2630 (11.2); 7.0991 (0.9); 7.0776 (1.0); 5.7308 (1.0); 5.7092 (2.0); 5.6875 (1.0); 5.3020 (10.9); 3.9779 (16.0); 2.5803 (0.8); 2.5597 (0.9); 1.8579 (0.7); 1.8411 (1.4); 1.8203 (1.3); 1.7995 (0.6); 1.7047 (0.6); 1.6823 (0.8); 1.6288 (0.5); 1.6206 (0.7); 1.6087 (1.0); 1.5895 (7.9); 1.5808 (1.6); 1.4171 (0.8); 1.3936 (0.8); 1.3666 (0.5); -0.0002 (13.2); -0.0083 (0.8) I.1-328: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6130 (2.7); 8.6070 (3.4); 8.5656 (3.2); 8.5597 (2.5); 8.2594 (3.6); 8.2386 (4.0); 7.8481 (4.0); 7.8274 (3.6); 7.5010 (3.3); 7.4959 (2.6); 7.4806 (1.1); 7.4757 (1.2); 7.2634 (8.4); 7.1294 (1.3); 7.1143 (1.3); 7.1079 (1.3); 5.7363 (1.0); 5.7148 (2.0); 5.6932 (1.0); 5.3020 (10.5); 3.9798 (16.0); 2.5830 (0.8); 2.5629 (0.8); 1.8731 (0.5); 1.8638 (0.8); 1.8530 (0.8); 1.8437 (1.4); 1.8325 (0.6); 1.8229 (1.3); 1.8018 (0.5); 1.7092 (0.6); 1.6866 (0.8); 1.6335 (0.5); 1.6253 (0.6); 1.6046 (6.5); 1.5851 (1.2); 1.5782 (1.0); 1.4195 (0.7); 1.3928 (0.8); 1.3692 (0.5); -0.0002 (10.0); -0.0082 (0.5) I.1-329: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6097 (2.3); 8.6038 (2.9); 8.5696 (2.8); 8.5637 (2.1); 8.2563 (3.2); 8.2356 (3.6); 7.8442 (3.6); 7.8235 (3.2); 7.6990 (5.4); 7.6943 (5.3); 7.5144 (1.6); 7.5099 (2.6); 7.5053 (1.3); 7.2622 (19.9); 7.0821 (0.8); 7.0617 (0.8); 5.7213 (0.9); 5.7000 (1.7); 5.6781 (0.9); 5.3021 (4.7); 3.9791 (13.7); 2.5845 (0.8); 2.5640 (0.8); 1.8633 (0.8); 1.8539 (0.8); 1.8418 (1.2); 1.8204 (1.0); 1.7088 (0.6); 1.6867 (0.7); 1.6229 (0.6); 1.6132 (0.8); 1.6043 (1.1); 1.5953 (1.1); 1.5832 (1.1); 1.5660 (16.0); 1.4156 (0.7); 1.3920 (0.8); 1.2611 (0.5); 0.8817 (0.5); -0.0002 (23.7); -0.0082 (1.3) BCS241005-Foreign STR 170 I.1-330: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5972 (2.7); 8.5914 (3.4); 8.5633 (3.4); 8.5574 (2.4); 8.2542 (3.7); 8.2334 (4.2); 7.8638 (4.1); 7.8431 (3.7); 7.4849 (3.1); 7.3302 (2.3); 7.2625 (17.1); 7.2024 (2.0); 7.1974 (2.5); 7.1927 (1.6); 7.0657 (1.0); 7.0442 (1.1); 5.7209 (1.0); 5.6992 (2.0); 5.6776 (1.0); 5.3020 (6.3); 3.9759 (15.6); 3.8511 (16.0); 2.5807 (0.9); 2.5601 (0.9); 1.8666 (1.0); 1.8570 (0.9); 1.8462 (1.5); 1.8368 (0.8); 1.8251 (1.3); 1.8037 (0.6); 1.7045 (0.7); 1.6815 (0.9); 1.6596 (0.6); 1.6177 (0.8); 1.6099 (1.1); 1.5996 (1.3); 1.5909 (1.5); 1.5726 (14.3); 1.4162 (0.8); 1.3930 (0.9); 1.3661 (0.6); -0.0002 (20.3) I.1-331: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6418 (1.7); 8.6358 (2.0); 8.5985 (2.0); 8.5927 (1.5); 8.2338 (2.3); 8.2133 (2.5); 7.7619 (2.6); 7.7413 (2.3); 7.6024 (1.9); 7.4026 (1.4); 7.2617 (26.1); 7.2210 (1.6); 5.6858 (0.6); 5.6682 (0.8); 5.6499 (0.6); 3.9726 (9.4); 1.5556 (16.0); 1.4296 (8.9); 1.4232 (4.9); 1.4062 (4.1); 0.9236 (0.7); 0.9075 (2.4); 0.8974 (1.1); 0.8346 (1.3); 0.8249 (2.5); 0.8084 (0.8); -0.0002 (28.1) I.1-332: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6423 (2.8); 8.6363 (3.4); 8.5999 (3.3); 8.5939 (2.5); 8.2344 (3.8); 8.2137 (4.2); 7.7629 (4.2); 7.7422 (3.8); 7.5967 (2.9); 7.4380 (2.2); 7.2620 (24.7); 7.2105 (2.2); 5.6908 (0.9); 5.6725 (1.2); 5.6543 (0.9); 3.9728 (16.0); 3.0037 (0.9); 2.9862 (1.2); 2.9690 (1.0); 1.5648 (11.0); 1.4253 (6.6); 1.4086 (6.4); 1.2860 (15.6); 1.2688 (15.2); -0.0002 (26.2); -0.0080 (1.3) I.1-333: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6376 (6.2); 8.6336 (7.2); 8.5773 (6.4); 8.5733 (5.8); 8.2246 (7.8); 8.2106 (8.8); 7.7418 (8.1); 7.7278 (8.1); 7.5923 (2.8); 7.5895 (3.5); 7.5785 (2.7); 7.5757 (4.0); 7.5649 (6.6); 7.5624 (5.2); 7.2903 (1.7); 7.2804 (1.3); 7.2771 (1.6); 7.2603 (33.7); 7.2414 (0.3); 7.1170 (5.5); 7.1033 (5.3); 5.6823 (0.5); 5.6710 (1.8); 5.6586 (2.3); 5.6469 (1.9); 5.6356 (0.5); 3.9714 (37.1); 3.9525 (0.3); 2.0432 (0.4); 1.5635 (50.0); 1.5450 (0.4); 1.4001 (13.7); 1.3890 (13.9); 1.2845 (0.3); 1.2583 (0.7); 0.8819 (0.4); 0.0755 (1.0); 0.0697 (22.6); 0.0635 (1.1); 0.0053 (1.4); -0.0001 (38.6); -0.0056 (1.8); -0.0191 (0.3) I.1-334: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1499 (1.6); 9.4968 (4.0); 9.4771 (4.3); 8.7517 (9.0); 8.7457 (10.8); 8.7003 (11.7); 8.6943 (10.0); 8.5632 (15.7); 8.3197 (7.0); 8.0991 (10.8); 8.0782 (14.2); 7.9404 (13.3); 7.9196 (10.6); 5.1678 (2.6); 5.1475 (3.8); 5.1443 (3.7); 5.1240 (2.9); 3.3456 (7.7); 2.6788 (0.5); 2.5325 (1.8); 2.5188 (36.6); 2.5146 (71.2); 2.5102 (92.8); 2.5057 (69.7); 2.5015 (37.9); 2.3371 (0.5); 2.2739 (1.2); 2.2571 (1.9); 2.2500 (1.7); 2.2404 (1.8); 2.2334 (2.0); 2.2165 (1.4); 2.2000 (0.6); 1.2740 (0.6); 1.2597 (0.6); 1.2283 (2.5); 1.1841 (2.2); 1.1723 (1.8); 1.1459 (0.7); 0.9442 (15.7); 0.9278 (16.0); 0.7773 (0.6); 0.5129 (14.2); 0.4961 (14.6); -0.0002 (14.3); -0.0084 (1.3) BCS241005-Abroad STR 171 I.1-335: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7242 (0.8); 8.7182 (1.0); 8.6759 (1.1); 8.6699 (0.9); 8.1730 (0.9); 8.1680 (0.9); 8.0900 (1.0); 8.0693 (1.3); 7.9451 (1.2); 7.9244 (1.0); 7.8622 (0.6); 7.8570 (0.5); 7.7547 (1.0); 7.7338 (0.7); 3.3333 (16.0); 2.5110 (25.1); 2.5070 (47.2); 2.5026 (60.2); 2.4982 (42.8); 2.4940 (20.8); 2.0865 (2.9); 1.2343 (0.8); 1.1805 (1.4); 1.1689 (1.4); 1.1395 (1.0); 0.9126 (1.5); 0.8962 (1.5); 0.4714 (1.4); 0.4545 (1.3); -0.0002 (8.4) I.1-337: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3540 (0.7); 9.3360 (0.7); 8.7042 (1.3); 8.6984 (1.7); 8.6704 (1.8); 8.6644 (1.3); 8.4895 (2.7); 8.3101 (1.2); 8.0689 (1.7); 8.0485 (2.3); 7.9389 (2.2); 7.9185 (1.7); 5.4611 (0.6); 5.4552 (0.5); 3.3353 (16.0); 2.5076 (43.5); 2.5036 (54.9); 2.4995 (40.2); 2.0873 (4.1); 1.9103 (2.6); 1.7152 (0.6); 1.3551 (0.7); 1.2329 (1.2); -0.0002 (7.3) I.1-338: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1442 (0.7); 9.0108 (2.2); 8.9929 (2.4); 8.6845 (4.2); 8.6786 (5.5); 8.6517 (5.9); 8.6457 (4.3); 8.1160 (5.0); 8.1111 (4.8); 8.0914 (5.4); 8.0708 (7.5); 7.9707 (7.2); 7.9502 (5.2); 7.8458 (2.1); 7.8408 (1.9); 7.8248 (3.1); 7.8198 (2.9); 7.7445 (5.4); 7.7235 (3.7); 5.3945 (1.4); 5.3763 (1.7); 5.3697 (1.7); 5.3514 (1.5); 3.3375 (14.8); 2.8080 (0.5); 2.7890 (0.9); 2.7665 (1.0); 2.7464 (0.6); 2.6734 (0.6); 2.5087 (70.4); 2.5044 (88.7); 2.5001 (63.6); 2.3313 (0.7); 2.0876 (16.0); 2.0049 (1.0); 1.9909 (2.6); 1.9112 (0.8); 1.7165 (0.7); 1.6955 (1.4); 1.6740 (1.9); 1.6308 (0.7); 1.5666 (1.1); 1.5600 (1.2); 1.5397 (1.7); 1.5296 (1.6); 1.2598 (1.0); 1.2388 (1.4); 1.1931 (0.8); 1.1816 (0.8); 1.1753 (1.3); 1.1695 (0.8); 1.1575 (0.6); - 0.0002 (12.2); -0.0084 (0.7) I.1-346: 1H-NMR (400 MHz, CDCl3): δ= 8.6536 (2.9); 8.6476 (3.5); 8.6095 (3.4); 8.6035 (2.6); 8.3868 (2.3); 8.3673 (2.4); 8.2662 (5.4); 8.2341 (4.0); 8.2133 (4.3); 7.7507 (4.2); 7.7299 (3.8); 7.4613 (2.5); 7.4392 (2.5); 7.2654 (6.0); 7.2461 (1.4); 7.2264 (1.4); 6.3869 (4.7); 5.6777 (0.9); 5.6602 (1.2); 5.6417 (0.9); 3.9720 (16.0); 3.5734 (8.0); 3.2864 (0.5); 2.1737 (5.6); 1.4368 (5.9); 1.4200 (5.8); 1.2561 (1.4); -0.0002 (7.1) I.1-347: 1H-NMR (400 MHz, CDCl3): δ= 8.6108 (0.7); 8.5963 (0.7); 8.5641 (0.5); 8.5582 (0.6); 8.5100 (0.6); 8.2042 (0.8); 8.1842 (1.5); 8.1645 (0.8); 7.7189 (0.9); 7.6979 (1.6); 7.6870 (0.7); 7.6769 (0.9); 7.6668 (0.9); 7.3837 (0.5); 7.3616 (0.9); 7.2658 (2.7); 3.9571 (3.7); 3.9539 (3.5); 3.9433 (0.7); 3.7886 (0.8); 3.7711 (9.1); 2.1740 (16.0); 1.7215 (2.3); 1.6478 (2.6); 1.6249 (0.7); 1.3558 (1.2); 1.3390 (1.2); 1.3241 (1.3); 1.3074 (1.3); 1.2558 (0.5); - 0.0002 (3.2) BCS241005-Abroad STR 172 I.1-348: 1H-NMR (400 MHz, CDCl3): δ= 8.6591 (1.4); 8.6531 (1.7); 8.6124 (1.6); 8.6064 (1.3); 8.4467 (1.2); 8.4271 (1.2); 8.2749 (2.8); 8.2353 (1.9); 8.2146 (2.1); 7.7485 (2.0); 7.7277 (1.9); 7.4720 (1.2); 7.4498 (1.3); 7.2629 (7.5); 7.2366 (0.7); 7.2166 (0.7); 5.6651 (0.6); 3.9735 (7.7); 3.7880 (16.0); 2.1744 (4.8); 1.6064 (1.0); 1.4394 (2.9); 1.4227 (2.9); 1.2566 (0.6); -0.0002 (9.0) I.1-349: 1H-NMR (400 MHz, CDCl3): δ= 8.6016 (2.2); 8.5961 (4.9); 8.5917 (3.0); 8.5856 (1.0); 8.5766 (2.3); 8.5706 (1.4); 8.2001 (2.5); 8.1935 (2.7); 8.1886 (0.9); 8.1836 (0.9); 8.1787 (2.9); 8.1720 (2.9); 7.6952 (2.7); 7.6904 (0.9); 7.6830 (0.5); 7.6788 (3.5); 7.6739 (3.2); 7.6696 (0.5); 7.6623 (0.8); 7.6574 (2.5); 7.2626 (15.2); 5.4342 (0.7); 5.4169 (1.0); 5.3997 (0.7); 5.3004 (16.0); 4.9722 (0.7); 4.9578 (0.8); 4.9431 (0.7); 4.9287 (0.7); 4.8954 (0.7); 4.8805 (0.8); 4.8673 (0.7); 4.8524 (0.7); 3.9621 (13.8); 3.9585 (13.2); 3.2737 (0.6); 3.2709 (0.6); 3.2460 (1.0); 3.2434 (1.0); 3.2325 (0.6); 3.2305 (0.6); 3.2175 (1.1); 3.2152 (1.0); 3.1530 (0.6); 3.1510 (0.6); 3.1386 (0.6); 3.1365 (0.6); 2.0204 (5.8); 1.9778 (6.1); 1.6035 (1.4); 1.3494 (4.3); 1.3381 (4.3); 1.3327 (4.6); 1.3213 (4.1); 0.0079 (0.6); -0.0002 (22.1); -0.0085 (0.7) I.1-351: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6931 (0.5); 8.6453 (0.6); 8.6389 (5.8); 8.6316 (0.5); 8.3818 (0.7); 8.3644 (0.8); 8.0575 (0.5); 7.9820 (2.2); 7.9772 (0.7); 7.9655 (0.8); 7.9607 (2.6); 7.6434 (2.5); 7.6385 (0.8); 7.6268 (0.7); 7.6220 (2.2); 7.3241 (1.4); 7.3186 (9.1); 7.3120 (1.8); 7.3064 (0.5); 5.0216 (0.8); 5.0045 (0.5); 3.8991 (2.6); 3.8950 (9.7); 3.6968 (0.6); 3.6508 (0.8); 3.3195 (16.0); 3.3027 (0.7); 3.3001 (0.7); 3.2585 (0.6); 3.2559 (0.6); 2.5407 (0.6); 2.5240 (0.7); 2.5193 (1.0); 2.5105 (15.1); 2.5060 (33.3); 2.5014 (46.8); 2.4968 (32.5); 2.4922 (14.4); 1.9887 (1.5); 1.9314 (5.6); 1.8874 (1.1); 1.3466 (2.9); 1.3298 (2.9); 1.2491 (1.1); 1.2326 (0.8); 1.1745 (0.9); 0.8581 (1.1); 0.0080 (0.9); -0.0002 (35.2); -0.0085 (1.0) I.1-352: 1H-NMR (400.6 MHz, d6-DMSO): δ= 8.7040 (0.7); 8.6918 (0.8); 8.6441 (1.7); 8.6379 (5.6); 8.6335 (4.5); 8.6273 (1.4); 8.3639 (1.0); 8.3463 (1.0); 8.0566 (0.6); 8.0354 (0.7); 7.9835 (3.2); 7.9788 (1.0); 7.9670 (1.1); 7.9622 (3.7); 7.6994 (0.7); 7.6782 (0.6); 7.6232 (3.5); 7.6184 (1.0); 7.6067 (1.0); 7.6020 (3.1); 7.4090 (0.6); 7.4054 (0.5); 7.3586 (0.6); 7.3345 (1.2); 7.3275 (2.2); 7.3200 (10.2); 7.3147 (2.1); 7.3115 (1.1); 7.3091 (1.4); 7.3052 (0.7); 5.0500 (0.7); 5.0329 (1.0); 5.0157 (0.7); 4.0378 (1.1); 4.0201 (1.1); 3.7008 (0.9); 3.6548 (1.1); 3.3197 (16.0); 3.3117 (1.6); 3.2672 (0.8); 3.2645 (0.8); 2.6701 (0.6); 2.5407 (1.4); 2.5239 (1.3); 2.5192 (1.9); 2.5105 (30.5); 2.5059 (67.0); 2.5013 (94.3); 2.4967 (64.8); 2.4922 (28.4); 2.3284 (0.6); 1.9886 (5.2); 1.9350 (7.9); 1.9087 (1.3); 1.8916 (1.5); 1.3553 (1.4); 1.3454 (4.0); 1.3285 (4.0); 1.2498 (0.8); 1.2330 (1.0); 1.1922 (1.5); 1.1809 (0.6); 1.1744 (3.1); 1.1566 (1.5); 0.0080 (1.9); -0.0002 (70.8); -0.0085 (2.0) BCS241005-Abroad STR 173 I.1-353: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7119 (0.6); 8.7061 (0.8); 8.6755 (0.8); 8.6694 (0.6); 8.6491 (0.5); 8.3359 (0.5); 8.3317 (0.5); 8.2528 (0.6); 8.0901 (0.8); 8.0696 (1.0); 7.8424 (0.9); 7.8298 (0.9); 7.8257 (1.0); 6.6179 (0.6); 5.7615 (2.1); 3.8818 (3.1); 3.3327 (16.0); 2.8424 (2.0); 2.8378 (1.8); 2.5066 (42.0); 2.5022 (52.7); 2.4979 (37.8); 1.5162 (1.1); 1.4990 (1.1); -0.0002 (12.2); -0.0083 (0.7) I.1-354: 1H-NMR(400.6 MHz, d6-DMSO): δ= 7.8269 (0.6); 3.3310 (16.0); 2.8450 (0.9); 2.8402 (0.8); 2.6707 (0.6); 2.5102 (39.2); 2.5062 (73.9); 2.5018 (94.4); 2.4974 (67.4); 2.4931 (33.1); 2.3291 (0.7); 1.4936 (0.5); -0.0002 (43.8); -0.0085 (2.4) I.1-355: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0665 (1.6); 9.0483 (1.6); 8.6892 (3.0); 8.6832 (4.1); 8.6583 (4.4); 8.6523 (3.1); 8.0830 (3.8); 8.0623 (5.3); 7.9526 (5.0); 7.9320 (3.7); 7.8068 (1.2); 7.7843 (1.3); 7.6979 (2.4); 7.6292 (1.2); 7.6074 (1.2); 5.4138 (1.0); 5.3956 (1.2); 5.3890 (1.2); 5.3706 (1.0); 3.3364 (16.0); 2.8043 (0.6); 2.7821 (0.7); 2.6729 (0.6); 2.5082 (73.6); 2.5039 (93.9); 2.4995 (67.5); 2.3355 (0.6); 2.3309 (0.8); 2.1189 (0.7); 2.0873 (12.7); 2.0108 (0.7); 1.9104 (3.6); 1.7230 (0.6); 1.7004 (1.1); 1.6821 (1.4); 1.6409 (0.5); 1.5787 (0.8); 1.5603 (1.1); 1.5380 (1.1); 1.5187 (0.8); 1.3555 (1.4); 1.2986 (0.6); 1.2706 (0.8); 1.2581 (1.1); 1.2338 (1.5); 1.1813 (1.1); 1.1695 (1.6); 1.1406 (1.6); 1.0267 (0.5); 1.0109 (0.5); 0.8550 (0.6); -0.0002 (13.1); -0.0081 (0.7) I.1-356: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1104 (0.6); 9.0923 (0.6); 8.6913 (1.1); 8.6853 (1.4); 8.6587 (1.5); 8.6527 (1.1); 8.0815 (1.3); 8.0607 (1.9); 8.0156 (0.8); 8.0117 (1.3); 8.0078 (0.8); 7.9468 (1.8); 7.9261 (1.3); 7.7734 (1.5); 3.3342 (16.0); 2.5074 (42.1); 2.5030 (53.9); 2.4986 (38.7); 2.4944 (19.2); 2.0869 (3.4); 1.9098 (0.7); -0.0002 (8.7) I.1-357: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6413 (2.7); 8.6353 (3.3); 8.5952 (3.2); 8.5892 (2.4); 8.2318 (3.7); 8.2111 (4.0); 7.7997 (1.6); 7.7954 (2.6); 7.7908 (1.6); 7.7521 (4.0); 7.7314 (3.6); 7.6974 (1.4); 7.6781 (1.6); 7.4943 (0.9); 7.4769 (1.3); 7.4743 (1.3); 7.4048 (1.6); 7.3853 (2.4); 7.3656 (1.0); 7.3304 (0.8); 7.3109 (0.8); 7.2629 (11.2); 5.6868 (0.9); 5.6696 (1.1); 5.6506 (0.9); 3.9730 (16.0); 1.5870 (9.9); 1.4140 (6.3); 1.3972 (6.3); -0.0002 (12.0); -0.0084 (0.7) I.1-358: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6370 (2.7); 8.6310 (3.2); 8.5838 (3.1); 8.5778 (2.5); 8.2289 (3.6); 8.2080 (4.0); 7.7690 (3.7); 7.7644 (1.4); 7.7527 (5.6); 7.7479 (5.6); 7.7321 (3.8); 7.4290 (4.2); 7.4243 (1.4); 7.4077 (3.8); 7.3248 (0.8); 7.3053 (0.8); 7.2623 (18.7); 5.6898 (0.9); 5.6724 (1.1); 5.6536 (0.9); 3.9717 (16.0); 1.5727 (15.4); 1.4083 (6.2); 1.3916 (6.3); -0.0002 (20.0); -0.0083 (1.1) I.1-359: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6413 (1.8); 8.6354 (2.1); 8.5957 (2.1); 8.5898 (1.6); 8.2315 (2.5); 8.2110 (2.7); 7.9479 (1.9); 7.7510 (2.9); 7.7303 (2.9); 7.6482 (0.9); 7.6270 (1.0); 7.3436 (1.1); BCS241005-Abroad STR 174 7.3239 (1.9); 7.3041 (1.3); 7.2926 (0.9); 7.2622 (16.2); 5.6828 (0.6); 5.6641 (0.8); 5.6470 (0.6); 3.9730 (10.1); 1.5651 (16.0); 1.4135 (4.4); 1.3968 (4.4); 1.2613 (0.6); 0.8818 (0.6); -0.0002 (17.5) I.1-360: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6365 (2.8); 8.6305 (3.2); 8.5822 (3.2); 8.5763 (2.6); 8.2281 (3.8); 8.2073 (4.2); 7.7518 (4.2); 7.7310 (3.9); 7.6982 (3.4); 7.6769 (5.0); 7.5902 (4.9); 7.5689 (3.4); 7.3294 (1.0); 7.3104 (1.0); 7.2630 (9.3); 5.6862 (1.0); 5.6682 (1.2); 5.6501 (0.9); 3.9712 (16.0); 1.5944 (8.2); 1.4067 (6.6); 1.3900 (6.5); -0.0002 (10.1); -0.0084 (0.6) I.1-361: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6590 (0.5); 8.0426 (0.6); 7.7981 (0.5); 3.3320 (16.0); 2.5064 (39.0); 2.5020 (50.1); 2.4976 (36.1); 2.4934 (18.0); 1.4761 (0.6); 1.4587 (0.6); 1.3963 (1.7); 0.8241 (0.5); -0.0002 (9.6); -0.0084 (0.6) I.1-362: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1119 (0.5); 9.0576 (1.0); 9.0412 (1.0); 8.6833 (1.9); 8.6772 (2.8); 8.6601 (3.2); 8.6540 (2.1); 8.0683 (2.7); 8.0472 (3.2); 7.8051 (3.0); 7.7841 (2.6); 7.7318 (2.0); 7.5727 (1.4); 7.3741 (1.4); 5.3412 (0.6); 5.3242 (0.9); 5.3071 (0.6); 3.3345 (16.0); 2.9961 (0.6); 2.9789 (0.8); 2.9615 (0.6); 2.5256 (1.2); 2.5120 (29.8); 2.5077 (58.0); 2.5032 (75.5); 2.4987 (55.8); 2.4943 (29.8); 1.9901 (0.8); 1.4795 (3.3); 1.4623 (3.5); 1.3553 (0.6); 1.2410 (0.9); 1.2378 (1.0); 1.2254 (7.1); 1.2227 (6.8); 1.2083 (7.0); 1.2054 (6.4); 1.1747 (0.7); 1.1693 (0.5); 0.0078 (0.9); -0.0002 (16.8); - 0.0085 (1.2) I.1-363: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1553 (4.6); 9.1390 (4.8); 8.6873 (7.6); 8.6814 (11.0); 8.6636 (11.7); 8.6576 (7.6); 8.0648 (11.2); 8.0442 (13.1); 7.9614 (9.2); 7.8215 (4.8); 7.8171 (4.3); 7.7975 (5.1); 7.7931 (4.7); 7.7756 (12.9); 7.7551 (11.3); 5.3324 (0.7); 5.3157 (2.8); 5.2990 (4.3); 5.2822 (2.9); 5.2647 (0.8); 3.3417 (2.6); 2.6747 (0.6); 2.5098 (86.7); 2.5058 (107.0); 2.5017 (78.9); 2.3331 (0.9); 1.4775 (15.8); 1.4603 (16.0); 1.3564 (0.9); 1.1699 (0.6); -0.0002 (15.3) I.1-364: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1537 (2.2); 9.0639 (1.9); 9.0468 (1.9); 8.7306 (3.8); 8.7247 (4.6); 8.6952 (5.0); 8.6892 (3.6); 8.0991 (5.3); 8.0787 (6.0); 7.7826 (6.0); 7.7621 (5.2); 7.5670 (2.1); 7.5457 (2.8); 7.5432 (2.8); 7.4590 (2.2); 7.4411 (2.5); 7.4202 (1.6); 5.3038 (1.3); 5.2870 (2.0); 5.2699 (1.3); 3.3403 (16.0); 2.5086 (40.4); 2.5047 (49.5); 1.4384 (7.6); 1.4215 (7.5); 1.1699 (0.8); - 0.0002 (5.2) I.1-365: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6403 (2.8); 8.6344 (3.3); 8.5958 (3.4); 8.5898 (2.6); 8.2318 (3.9); 8.2113 (4.3); 7.7567 (4.2); 7.7360 (3.9); 7.4411 (3.1); 7.3867 (2.2); 7.2620 (19.0); 7.2492 (1.5); 7.0259 (2.2); 5.6789 (0.9); 5.6614 (1.3); 5.6431 (1.0); 3.9720 (16.0); 1.9826 (0.7); 1.9742 (0.8); 1.9618 (1.4); 1.9491 (0.8); 1.9408 (0.7); 1.5677 (7.6); 1.4164 (6.5); 1.3997 (6.5); 1.0811 (0.9); 1.0692 (2.3); BCS241005-Abroad STR 175 1.0647 (2.3); 1.0484 (2.3); 1.0438 (2.0); 1.0323 (0.9); 0.7810 (1.0); 0.7690 (3.0); 0.7649 (2.5); 0.7569 (2.6); 0.7525 (2.7); 0.7402 (0.8); -0.0002 (23.1); -0.0082 (1.3) I.1-366: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6523 (2.7); 8.6463 (3.1); 8.6012 (3.2); 8.5953 (2.5); 8.2323 (3.8); 8.2118 (4.1); 7.7368 (4.1); 7.7162 (3.8); 7.5756 (2.8); 7.4355 (1.3); 7.4138 (1.3); 7.3380 (1.0); 7.3192 (1.0); 7.2627 (13.8); 7.2510 (1.3); 7.2457 (1.6); 7.2306 (1.1); 7.2255 (1.4); 5.6645 (1.0); 5.6465 (1.3); 5.6288 (1.0); 3.9745 (15.3); 1.5788 (16.0); 1.4081 (6.6); 1.3914 (6.5); -0.0002 (14.5) I.1-367: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6467 (2.7); 8.6407 (3.2); 8.5941 (3.1); 8.5881 (2.5); 8.2314 (3.7); 8.2107 (4.0); 7.9006 (1.4); 7.8951 (1.4); 7.8833 (1.4); 7.8779 (1.4); 7.7437 (4.1); 7.7229 (4.4); 7.7178 (1.6); 7.7116 (1.1); 7.7070 (1.1); 7.7014 (1.0); 7.6959 (1.0); 7.6903 (0.9); 7.3011 (0.8); 7.2813 (0.9); 7.2627 (16.0); 7.2296 (1.5); 7.2082 (2.6); 7.1869 (1.3); 5.6708 (0.9); 5.6532 (1.1); 5.6348 (0.9); 3.9736 (16.0); 1.5797 (15.1); 1.4084 (6.4); 1.3918 (6.4); 1.2611 (0.6); 0.8818 (0.6); -0.0002 (16.8); - 0.0083 (1.0) I.1-368: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1084 (1.9); 9.0856 (3.0); 9.0693 (3.1); 8.6849 (5.2); 8.6792 (6.7); 8.6598 (7.2); 8.6540 (4.8); 8.0707 (7.2); 8.0502 (8.3); 7.7876 (8.3); 7.7672 (7.2); 7.7389 (6.2); 7.6247 (2.9); 7.6020 (4.6); 7.5740 (2.9); 5.3160 (1.9); 5.2990 (2.8); 5.2824 (1.9); 3.3258 (16.0); 2.5075 (68.3); 2.5038 (79.3); 2.3311 (0.7); 1.4692 (10.6); 1.4520 (10.6); 1.3566 (0.7); 1.1704 (0.6); - 0.0002 (27.0) I.1-369: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1051 (5.7); 9.0207 (4.4); 9.0045 (4.6); 8.6809 (6.9); 8.6756 (9.1); 8.6558 (9.8); 8.6515 (6.5); 8.0728 (10.6); 8.0531 (16.0); 8.0403 (5.1); 8.0367 (4.6); 7.8467 (2.3); 7.8419 (2.2); 7.8349 (2.5); 7.8279 (3.0); 7.8198 (2.8); 7.8134 (3.0); 7.8076 (3.1); 7.7973 (12.2); 7.7774 (10.6); 7.4978 (3.6); 7.4758 (6.6); 7.4535 (3.3); 5.3322 (0.6); 5.3155 (2.7); 5.2987 (4.2); 5.2821 (2.8); 5.2658 (0.8); 3.8226 (0.6); 3.3276 (8.7); 2.6741 (0.5); 2.5049 (81.5); 2.3331 (0.8); 1.4645 (15.6); 1.4474 (15.5); 1.3577 (1.6); 1.1890 (0.7); 1.1705 (1.0); 1.1507 (0.7); 0.0015 (28.0); -0.0002 (29.4) I.1-370: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6744 (7.2); 8.6685 (8.6); 8.6185 (8.6); 8.6125 (7.0); 8.2628 (10.0); 8.2423 (11.1); 7.7804 (10.8); 7.7600 (10.2); 7.5282 (3.3); 7.5085 (3.4); 7.4854 (8.2); 7.4637 (0.9); 7.4256 (5.9); 7.2609 (35.2); 7.0370 (5.7); 5.7632 (0.6); 5.7465 (2.4); 5.7289 (3.2); 5.7107 (2.4); 5.6930 (0.7); 3.7721 (0.7); 3.7563 (1.8); 3.7400 (0.8); 2.1322 (6.0); 2.0004 (0.8); 1.9877 (1.7); 1.9792 (2.0); 1.9670 (3.5); 1.9544 (2.2); 1.9460 (2.0); 1.9334 (1.1); 1.8747 (0.8); 1.8664 (0.9); 1.8585 (2.0); 1.8496 (1.0); 1.8425 (0.8); 1.4894 (15.6); 1.4727 (16.0); 1.4323 (2.3); 1.2577 (0.6); 1.2414 (1.2); 1.2229 (0.5); 1.0814 (2.1); 1.0692 (5.7); 1.0644 (6.0); 1.0483 (6.1); 1.0438 (5.6); 1.0323 (2.5); 0.7889 (2.3); 0.7770 (7.8); 0.7729 (6.6); 0.7648 (6.6); 0.7604 (7.8); 0.7481 (2.4); -0.0002 (42.9) BCS241005-Ausland STR 176 I.1-371: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.0995 (1.5); 9.0770 (1.6); 8.6932 (2.8); 8.6851 (4.4); 8.6612 (4.6); 8.6531 (3.0); 8.0648 (3.4); 8.0584 (3.5); 7.7966 (1.2); 7.7901 (1.1); 7.7685 (2.6); 7.7618 (5.6); 7.7353 (3.7); 7.7218 (4.6); 7.6938 (2.1); 7.4682 (3.3); 7.4649 (3.4); 7.2905 (2.0); 7.2863 (1.9); 7.2642 (1.8); 7.2600 (1.8); 5.4114 (0.9); 5.3888 (1.5); 5.3660 (1.0); 3.9453 (0.4); 3.8542 (15.8); 3.8181 (16.0); 3.3329 (19.2); 2.5092 (12.1); 2.5034 (16.2); 2.4976 (11.9); 1.4500 (5.5); 1.4272 (5.4); -0.0002 (3.8) I.1-372: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1291 (3.4); 9.0281 (4.4); 9.0119 (4.6); 8.6820 (7.8); 8.6760 (11.0); 8.6567 (11.6); 8.6508 (7.7); 8.0802 (10.8); 8.0598 (12.7); 7.8676 (5.8); 7.8635 (8.6); 7.8591 (5.6); 7.8085 (12.6); 7.7881 (11.0); 7.7605 (4.9); 7.7411 (5.4); 7.5892 (3.4); 7.5696 (4.5); 7.4754 (5.2); 7.4557 (7.9); 7.4360 (3.5); 5.3386 (0.6); 5.3216 (2.8); 5.3048 (4.3); 5.2878 (2.9); 5.2711 (0.8); 3.3416 (4.6); 2.5095 (65.4); 2.5053 (81.3); 2.5012 (59.4); 2.3321 (0.6); 1.4616 (16.0); 1.4444 (16.0); 1.3566 (1.8); 1.1822 (0.7); -0.0002 (38.1); -0.0078 (2.5) I.1-373: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1254 (8.8); 8.9738 (4.8); 8.9574 (4.9); 8.6697 (9.9); 8.6525 (10.4); 8.0783 (10.7); 8.0581 (12.2); 7.8443 (11.3); 7.8231 (13.8); 7.8123 (13.7); 7.7919 (10.9); 7.5067 (12.1); 7.4857 (10.6); 5.3191 (3.0); 5.3024 (4.3); 5.2853 (2.9); 3.3397 (6.8); 2.6741 (0.8); 2.5050 (96.4); 2.3312 (1.0); 1.4513 (16.0); 1.4344 (15.7); 1.1821 (0.9); -0.0002 (33.4) I.1-374: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1242 (4.6); 9.0343 (4.4); 9.0180 (4.5); 8.6810 (7.7); 8.6750 (11.0); 8.6555 (11.7); 8.6495 (7.8); 8.0791 (11.3); 8.0585 (13.2); 8.0104 (5.9); 8.0063 (8.8); 8.0021 (5.4); 7.8069 (13.2); 7.7958 (6.5); 7.7864 (12.0); 7.7765 (5.9); 7.7189 (3.9); 7.6991 (4.3); 7.4088 (4.6); 7.3891 (8.0); 7.3694 (3.9); 5.3330 (0.7); 5.3164 (2.7); 5.2995 (4.2); 5.2827 (2.8); 5.2659 (0.8); 3.6013 (0.6); 3.3371 (16.0); 2.6727 (0.8); 2.5082 (107.6); 2.5040 (134.6); 2.4997 (97.0); 2.3310 (1.0); 1.7592 (0.7); 1.4583 (15.6); 1.4411 (15.6); 1.3557 (0.8); -0.0002 (66.0); -0.0077 (3.9) I.1-375: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1049 (0.6); 8.9569 (0.6); 8.9408 (0.6); 8.6705 (1.1); 8.6645 (1.6); 8.6479 (1.6); 8.6418 (1.0); 8.0713 (1.6); 8.0510 (1.9); 7.8023 (1.9); 7.7821 (1.6); 7.7654 (1.5); 7.7441 (2.1); 7.6419 (2.1); 7.6206 (1.5); 5.2956 (0.6); 3.3172 (16.0); 2.6698 (0.9); 2.5046 (85.1); 2.5008 (107.0); 2.4969 (80.2); 2.3277 (1.0); 1.9881 (0.5); 1.4456 (2.3); 1.4285 (2.3); -0.0002 (41.8); - 0.0083 (2.8) I.1-376: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3012 (1.8); 9.2845 (1.8); 8.7136 (3.8); 8.6915 (3.9); 8.2309 (0.6); 8.1803 (3.8); 8.1397 (0.6); 8.1171 (0.8); 8.0877 (4.0); 8.0699 (4.3); 7.8360 (0.9); 7.8128 (2.3); 7.7868 (5.8); 7.7677 (4.0); 7.7267 (0.6); 7.7003 (2.7); 7.6793 (2.0); 6.1776 (0.6); 6.1605 (0.8); 6.1351 (1.3); 6.1188 (0.8); 6.0915 (0.7); 5.8836 (1.2); 5.8664 (1.9); 5.8488 (1.0); 5.2165 (2.1); 5.1911 (2.0); 4.9724 (2.1); 4.9296 (1.9); 3.9493 (1.5); 3.9000 (12.4); 3.3834 (3.2); 3.3333 (16.0); 2.6697 (0.8); BCS241005-Abroad STR 177 2.5514 (19.7); 2.5046 (120.0); 2.5012 (121.1); 2.3309 (0.7); 1.9935 (0.6); 0.0490 (3.5); 0.0022 (24.3); - 0.0002 (28.7); -0.0019 (28.5) I.1-377: 1H-NMR(600.3 MHz, MeOD): δ= 8.6951 (1.4); 8.6910 (1.6); 8.6342 (1.6); 8.6302 (1.5); 8.1999 (1.8); 8.1862 (2.0); 8.1085 (1.6); 8.1052 (1.7); 7.7840 (1.9); 7.7699 (2.1); 7.7656 (1.0); 7.7550 (0.9); 7.7516 (0.9); 7.6187 (1.7); 7.6048 (1.4); 6.1506 (0.3); 6.1392 (0.4); 6.1335 (0.4); 6.1221 (0.7); 6.1106 (0.4); 6.1050 (0.4); 6.0935 (0.4); 5.9896 (0.8); 5.9781 (0.7); 5.2573 (1.0); 5.2402 (0.9); 5.0222 (0.9); 4.9936 (0.9); 4.8459 (36.9); 4.8218 (0.4); 3.3320 (17.5); 3.3293 (34.5); 3.3266 (50.0); 3.3240 (37.7); 3.3214 (20.8); 3.3018 (0.3) I.1-378: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1411 (0.9); 9.1215 (1.0); 8.7300 (2.5); 8.7240 (3.1); 8.6797 (3.7); 8.6737 (3.1); 8.0929 (2.8); 8.0884 (0.9); 8.0764 (1.1); 8.0717 (3.8); 7.9327 (7.4); 7.9279 (10.0); 7.9225 (1.2); 7.9104 (1.0); 7.9059 (2.7); 7.8099 (1.8); 7.8051 (3.2); 7.8004 (1.5); 5.0980 (0.6); 5.0781 (0.8); 5.0744 (0.8); 5.0544 (0.7); 3.1741 (16.0); 2.5253 (0.5); 2.5165 (6.7); 2.5120 (14.4); 2.5074 (19.8); 2.5028 (13.5); 2.4983 (5.8); 2.4640 (1.0); 1.9144 (2.4); 1.2301 (0.7); 1.1836 (0.6); 1.1717 (1.0); 0.9151 (4.0); 0.8987 (3.9); 0.4838 (3.5); 0.4669 (3.4); -0.0002 (15.4) I.1-379: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0381 (2.2); 9.0200 (2.3); 8.6885 (5.4); 8.6824 (7.2); 8.6542 (8.2); 8.6481 (6.2); 8.0894 (6.0); 8.0851 (2.2); 8.0728 (2.5); 8.0683 (8.5); 7.9493 (7.8); 7.9448 (2.5); 7.9325 (2.2); 7.9283 (5.8); 7.8730 (14.1); 7.8682 (16.0); 7.8021 (4.0); 7.7973 (6.6); 7.7925 (3.1); 5.3992 (1.5); 5.3810 (1.6); 5.3743 (1.7); 5.3561 (1.5); 3.9121 (0.5); 3.5110 (2.2); 3.4131 (0.5); 3.2426 (0.6); 3.1730 (6.2); 2.8003 (0.8); 2.7790 (0.9); 2.7575 (0.5); 2.5287 (0.6); 2.5240 (0.9); 2.5153 (16.5); 2.5108 (35.5); 2.5062 (49.4); 2.5016 (34.6); 2.4971 (15.7); 2.0239 (0.7); 2.0161 (0.8); 2.0081 (0.8); 1.9960 (0.9); 1.9131 (2.8); 1.7249 (0.7); 1.7031 (1.2); 1.6979 (1.1); 1.6806 (1.6); 1.6593 (0.9); 1.6396 (0.6); 1.5941 (0.6); 1.5848 (0.8); 1.5771 (1.1); 1.5675 (0.9); 1.5587 (1.4); 1.5489 (1.1); 1.5393 (1.4); 1.5191 (0.8); 1.2995 (1.3); 1.2858 (0.9); 1.2588 (2.6); 1.2305 (2.0); 1.1890 (0.5); 1.1830 (0.7); 1.1711 (0.7); 0.8514 (0.6); 0.0080 (0.8); -0.0002 (30.8); -0.0085 (1.0) I.1-380: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9256 (1.1); 8.9073 (1.1); 8.6825 (2.2); 8.6766 (2.7); 8.6473 (2.9); 8.6413 (2.1); 8.0943 (2.6); 8.0737 (3.7); 7.9826 (3.5); 7.9620 (2.5); 7.6530 (2.4); 7.3785 (1.8); 7.3156 (1.6); 7.3108 (2.1); 7.3058 (1.2); 5.3897 (0.7); 5.3714 (0.8); 5.3644 (0.8); 5.3464 (0.7); 3.8138 (12.1); 3.3352 (16.0); 2.5074 (59.5); 2.5031 (74.4); 2.4988 (53.4); 2.3303 (0.6); 2.0868 (14.5); 2.0172 (0.6); 1.9099 (8.4); 1.6780 (0.9); 1.6641 (1.1); 1.6472 (0.7); 1.5308 (0.9); 1.5226 (0.9); 1.2252 (0.7); 1.1810 (0.6); 1.1691 (0.6); 1.1399 (0.6); -0.0002 (9.5) I.1-381: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0277 (0.9); 9.0081 (1.0); 8.7243 (1.9); 8.7184 (2.2); 8.6735 (2.4); 8.6676 (2.0); 8.0941 (2.2); 8.0734 (3.1); 7.9626 (2.9); 7.9421 (2.2); 7.7027 (2.1); 7.4283 BCS241005-Foreign STR 178 (1.3); 7.4244 (1.6); 7.3238 (1.3); 7.3192 (1.8); 7.3141 (1.1); 5.0806 (0.6); 5.0604 (0.8); 5.0370 (0.6); 3.8220 (10.5); 3.3345 (16.0); 2.5251 (1.6); 2.5073 (58.3); 2.5030 (74.4); 2.4987 (55.4); 2.0868 (3.2); 1.2339 (0.7); 1.1809 (1.1); 1.1692 (1.2); 0.9120 (3.5); 0.8957 (3.5); 0.4603 (3.1); 0.4435 (3.2); -0.0002 (9.8); -0.0084 (0.9) I.1-382: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6592 (1.6); 8.6532 (2.0); 8.6191 (1.8); 8.6132 (1.4); 8.0560 (1.6); 8.0260 (0.9); 8.0059 (0.9); 7.8540 (1.7); 7.6072 (1.3); 7.5271 (1.3); 7.3802 (0.7); 7.2605 (32.0); 3.9644 (9.4); 2.1878 (7.1); 1.5481 (16.0); 1.3321 (1.4); 1.3193 (1.4); 1.2625 (0.5); -0.0002 (30.8); -0.0082 (1.8) I.1-383: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6537 (1.6); 8.6476 (1.9); 8.6022 (1.7); 8.5961 (1.3); 8.0543 (1.5); 8.0254 (0.8); 8.0059 (0.8); 7.8028 (1.2); 7.6809 (0.7); 7.6763 (0.6); 7.6602 (1.0); 7.6554 (0.9); 7.5649 (1.8); 7.5441 (1.2); 7.3909 (0.6); 7.2606 (19.0); 3.9636 (9.6); 2.1888 (6.7); 1.5543 (16.0); 1.3319 (1.2); 1.3162 (1.2); -0.0002 (18.0); -0.0083 (0.9) I.1-384: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6446 (2.4); 8.6385 (3.3); 8.6136 (2.9); 8.6076 (2.0); 8.0522 (2.5); 8.0236 (1.3); 8.0040 (1.4); 7.5306 (2.4); 7.4482 (1.9); 7.3379 (0.8); 7.3190 (0.7); 7.2611 (17.8); 7.1709 (1.9); 3.9620 (16.0); 2.4344 (11.0); 2.1925 (11.2); 1.5636 (8.0); 1.3382 (2.0); 1.3225 (2.1); 1.2645 (0.7); 0.8819 (0.7); -0.0002 (16.8); -0.0084 (0.9) I.1-385: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6594 (1.6); 8.6533 (2.0); 8.6184 (1.8); 8.6123 (1.3); 8.0559 (1.4); 8.0264 (0.8); 8.0066 (0.8); 7.7121 (1.1); 7.7083 (1.6); 7.7044 (1.0); 7.5653 (1.1); 7.3757 (1.6); 7.2608 (16.4); 3.9646 (9.8); 2.1880 (6.7); 1.5555 (16.0); 1.3323 (1.2); 1.3194 (1.2); 0.8820 (0.5); -0.0002 (15.6); -0.0082 (0.8) I.1-386: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6955 (1.1); 8.6894 (1.4); 8.6612 (1.1); 8.6552 (0.8); 7.8869 (0.5); 7.8612 (0.8); 7.8253 (0.5); 4.0381 (1.3); 4.0203 (1.3); 3.3183 (16.0); 2.5100 (29.4); 2.5059 (55.4); 2.5015 (70.8); 2.4970 (50.4); 2.4928 (24.6); 2.1366 (0.7); 1.9887 (5.6); 1.1925 (1.5); 1.1747 (3.0); 1.1570 (1.5); -0.0002 (37.1); -0.0084 (2.1) I.1-387: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0875 (0.5); 9.0705 (0.5); 8.6909 (1.2); 8.6847 (1.6); 8.6586 (1.3); 8.6523 (1.0); 7.9244 (0.6); 7.8872 (0.9); 7.8395 (0.5); 7.8219 (0.6); 7.7987 (0.9); 7.7780 (0.6); 4.0557 (0.6); 4.0381 (1.7); 4.0203 (1.8); 4.0025 (0.6); 3.3180 (16.0); 2.6703 (0.5); 2.5058 (69.1); 2.5014 (88.4); 2.4970 (63.2); 2.4928 (31.1); 2.3330 (0.6); 2.3286 (0.7); 2.1394 (0.9); 1.9887 (7.3); 1.1925 (2.0); 1.1747 (3.9); 1.1569 (2.0); -0.0002 (52.3); -0.0083 (2.8) BCS241005-Ausland STR 179 I.1-388: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6852 (0.8); 8.6791 (1.0); 8.6501 (0.8); 8.6442 (0.6); 7.3470 (0.5); 4.0376 (0.9); 4.0200 (0.9); 3.3165 (16.0); 2.6695 (0.7); 2.5229 (2.3); 2.5093 (48.8); 2.5052 (93.3); 2.5008 (120.6); 2.4964 (86.7); 2.4920 (43.0); 2.3784 (2.9); 2.3278 (0.9); 2.1397 (0.5); 1.9883 (4.0); 1.1922 (1.0); 1.1744 (2.1); 1.1567 (1.0); -0.0002 (64.2); -0.0084 (3.6) I.1-389: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.0134 (0.8); 9.1039 (1.4); 9.0869 (1.4); 8.6960 (2.8); 8.6899 (3.9); 8.6616 (3.1); 8.6556 (2.4); 7.9425 (1.4); 7.8850 (1.4); 7.8445 (1.2); 7.8240 (1.3); 7.7554 (2.1); 7.7179 (1.2); 4.0560 (1.1); 4.0382 (3.5); 4.0204 (3.6); 4.0027 (1.2); 3.6014 (0.7); 3.3181 (16.0); 2.6704 (0.8); 2.5101 (57.0); 2.5060 (109.1); 2.5017 (141.4); 2.4972 (101.8); 2.4930 (50.5); 2.3288 (1.0); 2.1370 (2.0); 1.9889 (15.1); 1.9090 (0.7); 1.7600 (0.9); 1.4157 (0.9); 1.3554 (1.0); 1.1926 (4.0); 1.1748 (8.1); 1.1571 (4.0); -0.0002 (73.5); -0.0084 (4.0) I.1-390: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6309 (2.7); 8.6248 (3.3); 8.5861 (3.2); 8.5801 (2.4); 8.2310 (3.6); 8.2102 (4.0); 7.7711 (5.1); 7.7507 (4.6); 7.6031 (0.7); 7.5973 (0.7); 7.5913 (0.8); 7.5823 (0.9); 7.5762 (0.9); 7.5702 (0.9); 7.5644 (0.7); 7.2625 (18.8); 7.2398 (1.1); 7.2207 (1.0); 7.0654 (1.3); 7.0441 (1.6); 7.0409 (1.5); 7.0196 (1.2); 5.6932 (0.9); 5.6754 (1.1); 5.6570 (0.9); 3.9708 (16.0); 3.2683 (0.9); 3.2511 (1.2); 3.2340 (0.9); 1.5754 (14.8); 1.4142 (6.3); 1.3975 (6.3); 1.2887 (10.9); 1.2714 (10.8); - 0.0002 (19.9); -0.0083 (1.0) I.1-391: 1H-NMR(400.6 MHz, CDCl3): δ= 8.2112 (0.5); 7.7619 (0.5); 7.2618 (17.1); 3.9721 (1.9); 1.5539 (16.0); 1.4159 (0.8); 1.3994 (0.8); 1.2727 (1.9); 1.2554 (1.9); -0.0002 (18.1) I.1-392: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6346 (2.8); 8.6291 (3.3); 8.5861 (3.3); 8.5803 (2.6); 8.2315 (3.9); 8.2110 (4.3); 8.0107 (0.7); 7.7918 (2.9); 7.7866 (2.9); 7.7692 (4.3); 7.7488 (4.0); 7.5140 (1.2); 7.4933 (1.9); 7.4885 (1.7); 7.4461 (0.6); 7.4262 (0.6); 7.4051 (3.2); 7.3846 (2.3); 7.2613 (106.0); 6.9977 (0.7); 5.6954 (0.9); 5.6781 (1.3); 5.6595 (1.1); 3.9713 (16.0); 3.7852 (0.6); 3.4592 (0.6); 3.4413 (1.2); 3.4250 (1.4); 3.4078 (1.1); 1.5487 (11.5); 1.5104 (2.1); 1.4160 (6.8); 1.3991 (6.6); 1.2942 (4.1); 1.2815 (11.4); 1.2650 (10.9); 0.1450 (0.8); -0.0002 (131.8); -0.1491 (0.8) I.1-393: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6810 (2.5); 8.6750 (3.6); 8.6561 (3.5); 8.6501 (2.2); 8.0347 (1.5); 8.0312 (1.5); 8.0150 (1.7); 8.0114 (1.6); 7.9229 (1.5); 7.9195 (1.4); 7.8980 (1.5); 7.8946 (1.3); 7.8255 (2.9); 7.6298 (1.2); 7.6111 (1.9); 7.5922 (1.3); 7.5804 (2.1); 7.5138 (2.0); 7.2611 (14.9); 5.3442 (0.8); 5.3270 (1.1); 5.3093 (0.8); 3.9806 (16.0); 1.5639 (13.0); 1.4465 (5.0); 1.4298 (5.0); 1.2657 (0.8); 0.8819 (0.9); -0.0002 (16.5); -0.0083 (0.9) I.1-394: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6752 (1.9); 8.6694 (2.4); 8.6396 (2.4); 8.6336 (1.7); 8.0310 (1.1); 8.0109 (1.2); 7.9212 (1.1); 7.8965 (1.1); 7.7767 (1.6); 7.6498 (1.0); 7.6451 (0.9); 7.6291 (1.6); BCS241005-International STR 180 7.6244 (1.4); 7.6143 (1.5); 7.5959 (0.8); 7.5499 (2.2); 7.5292 (1.5); 7.2607 (18.8); 5.3546 (0.6); 5.3379 (0.9); 5.3201 (0.6); 3.9797 (11.1); 1.5527 (16.0); 1.4434 (3.9); 1.4268 (3.9); 1.2629 (0.5); -0.0002 (21.3) I.1-395: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6642 (2.4); 8.6584 (4.0); 8.6481 (4.2); 8.6429 (2.2); 8.0293 (1.8); 8.0091 (2.0); 7.9163 (1.9); 7.8912 (1.9); 7.6476 (1.3); 7.6288 (2.2); 7.6093 (1.2); 7.4985 (3.1); 7.4188 (2.5); 7.2605 (22.0); 7.2594 (22.1); 7.2117 (1.0); 7.1577 (2.6); 5.3525 (1.0); 5.3350 (1.4); 5.3180 (1.0); 3.9775 (16.0); 2.4208 (13.6); 1.5523 (11.6); 1.4544 (6.2); 1.4376 (6.0); -0.0002 (25.8); -0.0014 (25.2) I.1-396: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6811 (2.5); 8.6751 (3.5); 8.6550 (3.6); 8.6490 (2.3); 8.0348 (1.5); 8.0316 (1.6); 8.0150 (1.7); 8.0117 (1.7); 7.9231 (1.6); 7.8980 (1.6); 7.6802 (2.9); 7.6296 (1.3); 7.6108 (2.0); 7.5920 (1.2); 7.5386 (2.2); 7.3627 (2.1); 7.2615 (10.6); 5.3471 (0.8); 5.3296 (1.2); 5.3122 (0.8); 3.9807 (16.0); 1.5734 (9.3); 1.4453 (5.4); 1.4286 (5.3); 1.2649 (0.8); 0.8817 (0.8); -0.0002 (11.6); - 0.0081 (0.6) I.1-397: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1164 (1.1); 9.0994 (1.1); 8.7611 (2.3); 8.7550 (2.7); 8.7040 (2.8); 8.6978 (2.3); 8.0130 (2.4); 7.8624 (1.2); 7.8588 (1.2); 7.8426 (3.2); 7.8393 (2.8); 7.7614 (1.0); 7.7362 (1.0); 7.6965 (1.0); 7.6783 (2.9); 7.6587 (0.8); 5.1185 (0.6); 5.1010 (0.9); 5.0838 (0.6); 4.0568 (1.2); 4.0389 (3.7); 4.0212 (3.8); 4.0034 (1.4); 3.6020 (1.0); 3.3220 (11.9); 2.5114 (22.4); 2.5074 (42.2); 2.5030 (54.2); 2.4986 (38.8); 2.4944 (19.3); 1.9896 (16.0); 1.9101 (0.6); 1.7602 (1.1); 1.5056 (4.0); 1.4885 (4.0); 1.3563 (1.6); 1.1932 (4.2); 1.1754 (8.4); 1.1576 (4.2); -0.0002 (16.8); -0.0084 (1.0) I.1-398: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0881 (0.5); 8.7500 (0.9); 8.6967 (0.9); 7.8501 (1.9); 7.8298 (1.3); 7.7699 (0.9); 7.7515 (1.0); 7.7258 (0.5); 7.6763 (0.6); 3.3172 (16.0); 2.6662 (1.2); 2.5018 (58.8); 2.4978 (56.2); 1.9888 (1.1); 1.9855 (1.0); 1.5014 (1.8); 1.4847 (1.6); 1.1747 (0.6); 1.1713 (0.6); - 0.0002 (14.5); -0.0036 (14.0) I.1-399: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7433 (0.5); 8.6915 (0.6); 3.3184 (16.0); 2.5056 (37.6); 2.5012 (47.7); 2.4968 (33.9); 2.3591 (1.9); 1.4969 (0.8); 1.4797 (0.8); -0.0002 (17.1); -0.0084 (0.9) I.1-400: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7605 (0.9); 8.7544 (1.1); 8.7034 (1.1); 8.6973 (0.9); 7.8768 (0.6); 7.8730 (0.9); 7.8692 (0.6); 7.8577 (0.5); 7.8380 (0.6); 7.8344 (0.6); 7.7336 (0.8); 7.6741 (0.6); 7.6541 (0.8); 3.3201 (16.0); 2.5103 (18.5); 2.5062 (35.0); 2.5018 (44.9); 2.4973 (32.0); 2.4930 (15.7); 1.9889 (1.1); 1.9090 (0.8); 1.5063 (1.6); 1.4891 (1.6); 1.3554 (0.6); 1.1748 (0.6); -0.0002 (16.6); -0.0084 (0.9) BCS241005-Ausland STR 181 I.1-401: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6490 (2.7); 8.6430 (3.2); 8.5940 (3.2); 8.5880 (2.6); 8.2309 (3.9); 8.2104 (4.3); 7.7358 (4.2); 7.7154 (3.9); 7.3414 (2.9); 7.3369 (3.0); 7.3224 (3.4); 7.2610 (15.5); 6.9781 (0.7); 6.9622 (0.9); 6.9567 (1.4); 6.9508 (0.8); 6.9408 (0.5); 6.9351 (0.7); 5.6688 (1.0); 5.6512 (1.3); 5.6329 (1.0); 3.9736 (16.0); 1.5607 (9.3); 1.4046 (6.8); 1.3879 (6.9); 1.2631 (0.7); 0.8821 (0.7); - 0.0002 (19.3) I.1-402: 1H-NMR(300.0 MHz, d6-DMSO): δ= 13.5388 (0.8); 13.5301 (0.8); 9.1164 (4.4); 9.0946 (4.6); 8.7045 (8.0); 8.6965 (11.9); 8.6652 (12.2); 8.6571 (8.9); 8.0695 (9.6); 8.0632 (10.3); 7.9110 (7.2); 7.8844 (9.5); 7.8259 (9.8); 7.8212 (10.9); 7.7946 (3.5); 7.7881 (3.2); 7.7665 (6.9); 7.7601 (7.0); 7.7289 (6.2); 7.7235 (6.5); 7.7176 (13.7); 7.7025 (4.9); 7.6972 (4.9); 7.6896 (6.7); 7.5611 (0.4); 7.5227 (0.4); 5.7577 (2.1); 5.3219 (0.6); 5.2999 (2.7); 5.2776 (4.2); 5.2551 (2.8); 5.2329 (0.6); 4.0942 (0.8); 3.5087 (1.0); 3.3234 (4.6); 3.1695 (14.2); 2.7291 (0.3); 2.5030 (45.4); 1.4775 (16.0); 1.4546 (15.8); 1.2332 (0.7); - 0.0002 (13.0) I.1-405: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1093 (0.8); 9.0388 (2.5); 9.0226 (2.6); 8.6834 (4.4); 8.6774 (6.3); 8.6590 (6.7); 8.6530 (4.5); 8.0705 (6.4); 8.0499 (7.6); 7.7900 (7.3); 7.7693 (6.4); 7.5223 (4.1); 7.5066 (4.1); 7.4578 (1.0); 7.4521 (1.3); 7.4351 (1.8); 7.4294 (2.4); 7.4125 (1.0); 7.4069 (1.3); 5.3174 (1.6); 5.3007 (2.5); 5.2836 (1.7); 3.3273 (16.0); 2.5079 (57.8); 2.5037 (71.5); 2.4996 (52.8); 2.3307 (0.5); 1.4685 (9.3); 1.4514 (9.3); -0.0002 (15.4) I.1-406: 1H-NMR(400.6 MHz, CDCl3): δ= 13.2487 (5.2); 8.6784 (2.9); 8.6728 (3.2); 8.6058 (3.3); 8.6000 (2.7); 8.2398 (4.1); 8.2196 (4.5); 7.7028 (4.9); 7.6825 (4.8); 7.3621 (2.5); 7.3406 (2.8); 7.2625 (10.8); 7.0160 (2.9); 6.9948 (2.6); 5.6713 (1.0); 5.6536 (1.5); 5.6361 (1.0); 3.9801 (16.0); 2.0475 (0.8); 1.5797 (9.8); 1.4095 (7.0); 1.3929 (7.0); 1.2606 (0.9); -0.0002 (12.3) I.1-407: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.6554 (2.9); 13.1202 (3.0); 9.4879 (1.5); 9.4739 (1.5); 8.7022 (4.0); 8.6967 (7.2); 8.6886 (7.1); 8.6829 (3.6); 8.0680 (6.3); 8.0477 (7.2); 8.0049 (3.5); 7.9830 (3.7); 7.7516 (7.1); 7.7314 (6.3); 7.1962 (3.2); 7.1745 (3.1); 5.3776 (1.6); 5.3609 (2.5); 5.3439 (1.6); 3.3412 (16.0); 2.6733 (0.6); 2.5050 (90.8); 2.3325 (0.9); 1.5044 (9.1); 1.4873 (9.1); 1.3559 (1.2); 1.2314 (0.6); 1.1819 (0.8); -0.0002 (12.4) I.1-408: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6459 (0.9); 8.6402 (1.0); 8.5958 (1.1); 8.5898 (0.8); 8.2289 (1.3); 8.2083 (1.4); 7.7360 (1.4); 7.7156 (1.3); 7.4975 (1.0); 7.4931 (1.0); 7.3853 (1.1); 7.3812 (0.9); 7.2606 (16.3); 5.9916 (0.8); 3.9721 (5.1); 1.5521 (16.0); 1.4026 (2.1); 1.3860 (2.2); -0.0002 (15.6) I.1-409: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1038 (0.5); 10.9317 (0.6); 8.9838 (1.1); 8.9674 (1.1); 8.6782 (1.8); 8.6723 (2.5); 8.6534 (2.7); 8.6475 (1.7); 8.0761 (2.6); 8.0557 (3.1); 7.7903 (3.0); 7.7699 BCS241005-International STR 182 (2.6); 7.5570 (2.2); 7.5525 (2.1); 7.3083 (2.2); 7.3039 (2.0); 5.2814 (0.6); 5.2639 (1.0); 5.2473 (0.7); 3.3194 (16.0); 2.6703 (0.6); 2.5057 (80.6); 2.5016 (100.4); 2.4974 (72.8); 2.3288 (0.8); 1.4388 (3.7); 1.4216 (3.7); -0.0002 (29.2) I.1-410: 1H-NMR(400.6 MHz, CDCl3): δ= 12.2773 (5.5); 8.6797 (2.7); 8.6737 (3.3); 8.6308 (3.2); 8.6248 (2.5); 8.2371 (3.8); 8.2164 (4.0); 7.7081 (4.1); 7.6874 (3.7); 7.5347 (5.8); 7.5143 (0.9); 7.2611 (11.9); 7.1052 (5.4); 5.6547 (0.9); 5.6374 (1.2); 5.6192 (0.9); 3.9772 (16.0); 1.5724 (12.5); 1.4140 (6.4); 1.3974 (6.5); -0.0002 (13.4); -0.0081 (0.8) I.1-411: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2948 (1.2); 9.2777 (1.3); 8.7180 (2.1); 8.7121 (3.7); 8.7008 (3.9); 8.6949 (2.1); 8.1103 (5.0); 8.0881 (3.7); 8.0678 (4.2); 7.7554 (4.0); 7.7351 (3.6); 7.1558 (5.2); 5.7575 (1.1); 5.3766 (0.9); 5.3595 (1.3); 5.3425 (0.9); 3.3279 (16.0); 2.5077 (39.0); 2.5037 (48.7); 2.4997 (35.4); 1.4622 (5.1); 1.4453 (5.1); -0.0002 (8.4) I.1-412: 1H-NMR(400.6 MHz, CDCl3): δ= 8.8921 (1.1); 8.8879 (1.0); 8.7009 (1.0); 8.6953 (1.0); 8.6596 (1.1); 8.6537 (1.2); 8.5966 (1.2); 8.5908 (1.0); 8.2371 (1.5); 8.2165 (1.6); 8.1272 (0.7); 8.1219 (1.0); 8.1168 (0.6); 7.7356 (1.6); 7.7148 (1.5); 7.2605 (19.0); 3.9766 (6.0); 1.5493 (16.0); 1.4226 (2.6); 1.4059 (2.5); -0.0002 (21.9) I.1-413: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6657 (1.8); 8.6597 (2.1); 8.5984 (2.0); 8.5924 (1.7); 8.5307 (1.6); 8.5180 (1.7); 8.2363 (2.5); 8.2158 (2.8); 7.7252 (2.7); 7.7046 (2.6); 7.6898 (2.2); 7.5830 (1.2); 7.5704 (1.2); 7.4796 (0.6); 7.4604 (0.6); 7.2616 (14.6); 5.6745 (0.6); 5.6566 (0.8); 5.6386 (0.6); 3.9772 (10.5); 1.5702 (16.0); 1.5689 (16.0); 1.4146 (4.4); 1.3979 (4.4); 1.2600 (0.5); -0.0002 (13.7) I.1-414: 1H-NMR(400.6 MHz, d6-DMSO):δ= 9.2834 (1.1); 9.2671 (1.2); 8.6927 (2.0); 8.6866 (3.2); 8.6694 (3.4); 8.6633 (2.2); 8.5162 (2.0); 8.5035 (2.1); 8.0690 (3.1); 8.0484 (3.7); 7.8120 (2.6); 7.7783 (3.6); 7.7577 (3.1); 7.6996 (1.6); 7.6963 (1.4); 7.6870 (1.6); 7.6835 (1.4); 5.3254 (0.7); 5.3085 (1.2); 5.2916 (0.8); 3.3264 (16.0); 2.5248 (0.9); 2.5111 (23.1); 2.5070 (44.7); 2.5027 (58.1); 2.4982 (42.0); 2.4941 (21.2); 1.4781 (4.3); 1.4609 (4.4); -0.0002 (12.3); -0.0083 (0.7) I.1-415: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8511 (0.6); 8.8466 (0.6); 8.7515 (0.6); 8.7456 (0.6); 8.6930 (0.5); 8.6870 (0.8); 8.6675 (0.8); 8.6615 (0.5); 8.2468 (0.6); 8.0694 (0.8); 8.0491 (0.9); 7.7893 (0.8); 7.7689 (0.8); 3.3234 (16.0); 2.5061 (15.5); 2.5018 (19.8); 2.4975 (14.1); 1.4808 (1.1); 1.4636 (1.0); -0.0002 (4.6) I.1-416: 1H-NMR(400.6 MHz, CDCl3): δ= 9.3388 (4.4); 9.1487 (10.4); 8.6692 (2.8); 8.6632 (3.1); 8.5932 (3.1); 8.5872 (2.5); 8.2424 (3.7); 8.2216 (4.0); 7.7365 (4.0); 7.7158 (3.7); 7.5103 (0.8); 7.4912 BCS241005-Foreign STR 183 (0.8); 7.2632 (10.6); 5.7159 (0.9); 5.6982 (1.2); 5.6799 (0.9); 4.1310 (0.7); 4.1130 (0.7); 3.9785 (16.0); 2.0455 (3.1); 1.6055 (11.4); 1.4315 (6.6); 1.4148 (6.6); 1.2773 (0.8); 1.2595 (1.7); 1.2417 (0.8); -0.0002 (12.0); -0.0083 (0.7) I.1-418: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6479 (1.0); 8.6418 (1.3); 8.5882 (1.1); 8.5821 (0.9); 8.2328 (1.3); 8.2116 (1.5); 7.7425 (1.5); 7.7260 (0.5); 7.7214 (1.4); 7.2984 (0.7); 7.2754 (0.7); 7.2606 (20.0); 7.2536 (0.6); 3.9733 (6.8); 1.5494 (16.0); 1.4126 (2.3); 1.3959 (2.3); 0.0079 (0.7); -0.0002 (23.6); -0.0085 (0.7) I.1-419: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6447 (2.5); 8.6386 (3.2); 8.5970 (2.7); 8.5909 (2.1); 8.2352 (3.2); 8.2305 (1.0); 8.2187 (1.1); 8.2139 (3.5); 8.2097 (0.5); 7.7613 (0.6); 7.7571 (3.5); 7.7523 (1.1); 7.7404 (1.3); 7.7357 (4.3); 7.5227 (1.3); 7.3802 (1.3); 7.3288 (0.6); 7.3093 (0.6); 7.2622 (7.9); 6.7649 (0.8); 6.7376 (0.9); 6.7210 (0.9); 6.6938 (0.9); 5.8805 (2.2); 5.8367 (2.0); 5.6931 (0.7); 5.6761 (0.8); 5.6739 (0.8); 5.6568 (0.7); 5.4370 (2.1); 5.4097 (2.0); 3.9727 (16.0); 1.5998 (6.7); 1.4269 (5.2); 1.4101 (5.2); -0.0002 (9.2) I.1-420: 1H-NMR(300.0 MHz, d6-DMSO): δ= 13.5173 (2.4); 9.2135 (4.6); 9.1919 (4.8); 8.7129 (7.7); 8.7050 (11.2); 8.6739 (11.3); 8.6660 (8.2); 7.9559 (9.8); 7.9107 (7.5); 7.8842 (9.9); 7.8351 (0.4); 7.8074 (10.2); 7.8032 (10.8); 7.7507 (7.7); 7.7224 (11.6); 7.6953 (4.7); 7.6905 (4.5); 6.5801 (0.5); 5.3389 (0.6); 5.3171 (2.7); 5.2947 (4.2); 5.2722 (2.8); 5.2496 (0.6); 3.3208 (22.7); 2.7284 (0.4); 2.5077 (40.1); 2.5024 (51.8); 2.4973 (38.0); 2.2713 (0.4); 1.9092 (0.3); 1.7545 (0.5); 1.6037 (0.4); 1.5799 (0.4); 1.4916 (16.0); 1.4688 (15.8); 1.3693 (0.3); 1.3556 (1.4); 1.2707 (1.0); 1.2338 (1.6); 1.1853 (0.9); 1.1694 (4.3); 1.0842 (0.6); 0.8521 (0.4); 0.1950 (0.4); -0.0001 (68.2) I.1-421: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.1030 (1.4); 9.0811 (1.5); 8.7210 (2.9); 8.7130 (3.9); 8.6761 (4.1); 8.6680 (3.1); 8.0533 (3.3); 8.0469 (3.4); 7.9389 (2.7); 7.9122 (3.6); 7.8665 (3.5); 7.8615 (3.7); 7.7881 (1.2); 7.7815 (1.1); 7.7594 (4.2); 7.7534 (4.4); 7.7321 (1.7); 7.7268 (1.7); 7.7144 (4.4); 7.6864 (2.0); 5.3196 (0.9); 5.2971 (1.4); 5.2746 (0.9); 3.9052 (16.0); 3.3429 (0.8); 2.5178 (2.2); 2.5126 (2.8); 2.0855 (3.6); 1.7692 (0.4); 1.4904 (5.3); 1.4675 (5.2); -0.0002 (1.2) I.1-422: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.1828 (1.3); 9.1605 (1.4); 8.7230 (2.8); 8.7149 (3.9); 8.6796 (4.1); 8.6715 (3.0); 7.9319 (2.1); 7.9264 (3.4); 7.9212 (4.8); 7.8944 (3.5); 7.8296 (3.3); 7.8246 (3.6); 7.7496 (2.2); 7.7362 (2.3); 7.7307 (2.0); 7.7091 (2.8); 7.7042 (3.6); 5.3281 (0.9); 5.3057 (1.3); 5.2831 (0.8); 3.8918 (16.0); 3.3215 (14.6); 3.2986 (0.3); 2.5081 (17.0); 2.5028 (21.6); 2.1837 (0.4); 1.4960 (5.1); 1.4731 (5.0); 1.3560 (2.5); 1.2335 (0.4); 0.0107 (0.5); -0.0001 (11.1); -0.0111 (0.4) BCS241005-Ausland STR 184 I.1-423: 1H-NMR(300.1 MHz, d6-DMSO): δ= 8.9571 (1.6); 8.9411 (1.7); 8.6739 (3.7); 8.6400 (4.3); 7.8186 (2.3); 7.7234 (3.1); 7.6642 (0.5); 7.5855 (4.2); 7.5107 (0.5); 7.4323 (2.2); 7.4062 (1.8); 5.0518 (0.9); 3.8855 (16.0); 3.8181 (5.2); 3.6347 (1.0); 3.3281 (12.8); 2.5027 (26.6); 1.4795 (3.4); 1.3658 (0.9); - 0.0002 (19.9) I.1-424: 1H-NMR(300.1 MHz, d6-DMSO): δ= 13.2256 (0.4); 13.1203 (2.5); 8.9786 (6.1); 8.9570 (6.2); 8.6641 (13.4); 8.6378 (16.0); 7.8541 (7.8); 7.7193 (12.2); 7.6329 (6.7); 7.6045 (11.4); 7.5813 (15.3); 7.5064 (0.7); 7.4287 (6.4); 7.4046 (5.8); 5.2079 (0.7); 5.0235 (2.9); 3.8094 (15.4); 3.6411 (2.7); 3.5136 (0.4); 3.4694 (0.3); 3.3238 (14.1); 3.2155 (0.4); 2.5099 (40.6); 2.5044 (50.8); 2.4991 (37.7); 2.2740 (0.3); 2.0765 (1.0); 1.4774 (10.6); 1.3443 (2.6); 1.2331 (0.6); -0.0001 (64.4) I.1-425: 1H-NMR(300.1 MHz, d6-DMSO): δ= 8.8365 (0.8); 8.6629 (2.2); 8.6311 (2.7); 7.9259 (1.3); 7.6661 (2.9); 7.6125 (2.0); 7.5867 (3.8); 7.4519 (0.9); 7.4276 (0.9); 5.0065 (0.5); 3.8933 (16.0); 3.8165 (2.7); 3.7784 (1.0); 3.6658 (0.5); 3.3190 (5.5); 2.5079 (9.3); 2.5024 (11.7); 2.4970 (8.6); 1.4638 (1.8); 1.3463 (0.5); -0.0002 (16.4) I.1-426: 1H-NMR(300.1 MHz, d6-DMSO): δ= 13.3121 (0.4); 13.1647 (1.2); 13.1497 (1.2); 13.0202 (0.5); 12.9195 (0.4); 12.5217 (0.4); 9.9797 (0.4); 8.8562 (3.4); 8.6534 (8.4); 8.6263 (9.6); 8.5501 (0.4); 8.1736 (0.5); 7.9586 (5.2); 7.6770 (10.4); 7.6174 (8.1); 7.5927 (16.0); 7.4363 (3.6); 7.4151 (3.5); 5.1864 (0.7); 5.1134 (0.4); 4.9832 (2.0); 3.8041 (10.1); 3.6853 (1.9); 3.6705 (2.0); 3.5221 (0.4); 3.4631 (0.5); 3.3177 (7.3); 3.1512 (0.4); 3.0648 (0.4); 2.7274 (0.5); 2.5079 (52.0); 2.5022 (65.5); 2.4967 (47.8); 2.3843 (0.5); 2.2818 (0.5); 1.7558 (0.4); 1.6824 (0.4); 1.5533 (0.5); 1.4623 (7.1); 1.3219 (1.9); 1.2342 (0.8); 0.1954 (0.5); 0.0694 (0.7); -0.0001 (100.9); -0.0112 (4.8); -0.1978 (0.4) I.1-427: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0954 (0.8); 9.0788 (0.9); 8.6817 (1.9); 8.6756 (3.0); 8.6588 (3.4); 8.6526 (2.2); 8.0626 (2.6); 8.0580 (0.9); 8.0461 (1.0); 8.0414 (3.3); 7.9858 (0.6); 7.9668 (1.2); 7.9615 (0.6); 7.9550 (0.7); 7.9450 (0.6); 7.9395 (0.5); 7.9335 (0.6); 7.7920 (3.0); 7.7874 (0.9); 7.7755 (0.9); 7.7709 (2.7); 7.6134 (1.0); 7.5916 (1.0); 7.5881 (1.0); 7.5665 (0.8); 5.3309 (0.6); 5.3139 (0.9); 5.2971 (0.6); 4.0561 (0.6); 4.0383 (2.0); 4.0206 (2.0); 4.0028 (0.7); 3.3209 (16.0); 2.5248 (1.1); 2.5201 (1.7); 2.5113 (23.2); 2.5067 (49.5); 2.5022 (68.3); 2.4976 (47.1); 2.4931 (20.8); 1.9937 (1.0); 1.9891 (9.3); 1.9093 (2.4); 1.4722 (3.4); 1.4549 (3.4); 1.3556 (1.2); 1.1927 (2.6); 1.1749 (5.4); 1.1695 (0.5); 1.1571 (2.6); 0.0080 (1.3); -0.0002 (42.2); -0.0085 (1.1) I.1-428: 1H-NMR(400.6 MHz, CDCl3): δ= 8.8453 (0.8); 8.8415 (1.3); 8.8378 (0.7); 8.6603 (1.7); 8.6543 (2.0); 8.6099 (1.3); 8.6029 (1.4); 8.5954 (1.7); 8.5893 (1.4); 8.2382 (2.1); 8.2335 (0.6); 8.2217 (0.7); 8.2169 (2.3); 7.8815 (0.5); 7.8790 (0.5); 7.8598 (0.5); 7.7379 (2.2); 7.7331 (0.7); 7.7213 (0.7); 7.7166 BCS241005-Foreign STR 185 (2.0); 7.2613 (20.1); 5.6858 (0.5); 3.9768 (10.7); 2.0455 (1.2); 1.5636 (16.0); 1.4251 (3.5); 1.4084 (3.5); 1.2596 (0.7); 0.0080 (0.8); -0.0002 (23.9); -0.0085 (0.6) I.1-429: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8176 (0.6); 8.8135 (1.1); 8.8095 (0.6); 8.7136 (1.0); 8.7066 (1.0); 8.6926 (1.0); 8.6865 (1.6); 8.6674 (1.7); 8.6613 (1.1); 8.0715 (1.4); 8.0549 (0.5); 8.0503 (2.0); 8.0457 (0.6); 7.7953 (1.6); 7.7907 (0.5); 7.7743 (1.4); 3.3262 (16.0); 2.5204 (0.6); 2.5115 (8.6); 2.5071 (18.3); 2.5025 (25.2); 2.4980 (17.5); 2.4934 (7.8); 1.4839 (1.9); 1.4666 (1.9); -0.0002 (7.7) I.1-430: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6769 (8.6); 8.6708 (10.7); 8.6226 (9.4); 8.6165 (7.7); 8.2671 (10.1); 8.2626 (3.4); 8.2506 (3.5); 8.2460 (11.8); 7.7810 (13.9); 7.7767 (10.9); 7.7650 (3.6); 7.7605 (10.8); 7.5560 (4.9); 7.5429 (2.8); 7.5232 (2.7); 7.3919 (4.6); 7.2606 (106.6); 6.9970 (0.6); 6.7720 (2.8); 6.7447 (3.1); 6.7282 (3.2); 6.7008 (3.2); 5.8932 (7.5); 5.8493 (6.7); 5.7745 (0.5); 5.7579 (2.2); 5.7390 (2.6); 5.7216 (2.2); 5.7048 (0.5); 5.4437 (7.2); 5.4164 (7.0); 3.7534 (1.2); 1.8737 (0.6); 1.8654 (0.6); 1.8571 (1.5); 1.8486 (0.6); 1.8405 (0.7); 1.4928 (16.0); 1.4761 (16.0); 1.4322 (1.3); 1.2425 (1.3); 1.2225 (0.5); 0.0080 (3.6); -0.0002 (130.0); -0.0084 (4.0); -0.0383 (0.5) I.1-431: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6573 (2.5); 8.6513 (2.9); 8.6062 (2.9); 8.6003 (2.3); 8.2789 (3.9); 8.2689 (5.2); 8.2584 (4.1); 8.0295 (2.0); 7.7868 (3.7); 7.7661 (3.4); 7.3331 (0.9); 7.3115 (1.0); 7.2621 (25.0); 5.6531 (1.0); 5.6337 (0.9); 4.5448 (1.4); 4.5413 (1.5); 4.5345 (2.3); 4.5286 (2.1); 4.5214 (1.6); 3.7829 (2.4); 3.7711 (3.2); 3.7595 (2.2); 3.4641 (16.0); 1.8069 (0.9); 1.7914 (1.2); 1.7752 (1.5); 1.7573 (1.0); 1.5661 (3.5); 1.2547 (2.7); 0.7701 (2.9); 0.7517 (6.0); 0.7332 (2.6); 0.0696 (0.6); -0.0002 (31.1); -0.0082 (1.5) I.1-432: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6573 (1.8); 8.6512 (2.3); 8.6103 (1.9); 8.6042 (1.5); 8.2664 (2.2); 8.2419 (2.1); 8.2372 (0.7); 8.2254 (0.8); 8.2207 (2.4); 8.0293 (1.0); 7.7941 (2.3); 7.7893 (0.7); 7.7775 (0.7); 7.7729 (2.0); 7.2611 (22.7); 3.9743 (0.6); 3.9562 (0.8); 3.9522 (1.0); 3.9345 (1.0); 3.8312 (0.6); 3.8124 (0.5); 3.7472 (0.5); 3.7333 (0.5); 1.8198 (0.6); 1.8042 (0.7); 1.7885 (1.0); 1.7704 (0.7); 1.5620 (16.0); 0.7773 (1.6); 0.7589 (3.7); 0.7402 (1.5); 0.0080 (0.8); -0.0002 (27.5); -0.0085 (0.8) I.1-433: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6572 (1.6); 8.6517 (2.3); 8.6403 (0.8); 8.6091 (1.6); 8.6032 (1.3); 8.3264 (1.9); 8.3059 (2.1); 8.2646 (2.8); 8.0266 (1.2); 7.8079 (2.0); 7.7873 (1.9); 7.7619 (0.8); 7.7582 (0.8); 7.7431 (0.5); 7.5128 (0.9); 7.4933 (0.8); 7.3238 (0.5); 7.3034 (0.6); 7.2914 (0.6); 7.2608 (17.1); 5.6561 (0.6); 5.6369 (0.6); 5.5467 (2.1); 5.5369 (2.0); 1.8164 (0.5); 1.8010 (0.7); 1.7844 (0.9); 1.7669 (0.6); 1.5629 (16.0); 1.2648 (0.6); 0.8820 (0.6); 0.7753 (1.6); 0.7570 (3.3); 0.7384 (1.5); -0.0002 (16.1) BCS241005-Ausland STR 186 I.1-434: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6644 (1.4); 8.6584 (1.7); 8.6258 (1.6); 8.6198 (1.2); 8.2770 (2.0); 8.2610 (3.2); 8.2566 (2.8); 8.0323 (1.1); 7.8515 (2.0); 7.8307 (1.8); 7.2814 (0.5); 7.2607 (19.4); 5.6210 (0.6); 5.6006 (0.5); 5.0248 (5.5); 1.8223 (0.5); 1.8181 (0.5); 1.8044 (0.7); 1.7995 (0.8); 1.7867 (0.5); 1.7814 (0.6); 1.5543 (16.0); 1.2623 (0.6); 0.8820 (0.6); 0.7809 (1.6); 0.7624 (3.3); 0.7438 (1.5); - 0.0002 (18.1); -0.0083 (1.1) I.1-435: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6505 (4.9); 8.6458 (5.6); 8.6040 (5.8); 8.5981 (4.5); 8.2620 (11.2); 8.2268 (7.1); 8.2067 (7.8); 8.0278 (4.8); 7.7784 (7.7); 7.7582 (7.1); 7.3060 (2.3); 7.2843 (2.8); 7.2605 (69.9); 7.2590 (67.1); 6.3689 (0.6); 5.6605 (1.0); 5.6438 (2.2); 5.6235 (2.2); 5.6072 (1.0); 4.6682 (4.0); 4.6524 (8.2); 4.6367 (4.3); 4.2436 (2.2); 4.2264 (7.0); 4.2086 (7.1); 4.1911 (2.8); 4.1761 (0.6); 2.8384 (4.3); 2.8224 (8.6); 2.8066 (4.3); 1.8273 (0.9); 1.8098 (2.0); 1.7935 (3.3); 1.7764 (3.7); 1.7582 (2.3); 1.7408 (1.0); 1.5487 (14.8); 1.3066 (8.2); 1.2900 (16.0); 1.2709 (10.3); 0.8976 (2.3); 0.8811 (5.2); 0.8638 (2.6); 0.7708 (5.9); 0.7524 (12.3); 0.7342 (5.8); -0.0002 (86.8); -0.0016 (85.0); -0.1515 (0.7) I.1-436: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6718 (0.7); 8.6658 (0.8); 8.6209 (0.8); 8.6148 (0.6); 8.2197 (0.8); 8.1984 (1.0); 7.9058 (0.6); 7.9007 (0.7); 7.7349 (0.9); 7.7137 (0.9); 7.5327 (0.8); 7.5119 (0.6); 7.2609 (12.4); 3.9742 (4.4); 1.5558 (16.0); -0.0002 (14.6) I.1-437: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6557 (1.9); 8.6496 (2.3); 8.6017 (2.0); 8.5956 (1.6); 8.2550 (2.2); 8.2504 (0.8); 8.2385 (0.8); 8.2338 (2.6); 7.7375 (2.4); 7.7329 (0.8); 7.7209 (0.8); 7.7163 (2.4); 7.7132 (1.4); 7.7090 (1.8); 7.7050 (1.1); 7.5691 (1.1); 7.3761 (1.0); 7.2614 (24.0); 5.6522 (0.6); 4.5546 (1.2); 4.5428 (1.3); 4.5305 (1.3); 3.8893 (1.4); 3.8772 (1.5); 3.8651 (1.3); 3.7412 (1.4); 3.7332 (1.2); 3.7302 (1.8); 3.7254 (1.3); 3.7182 (2.1); 3.6078 (2.1); 3.6007 (1.3); 3.5958 (1.7); 3.5930 (1.3); 3.5847 (1.4); 3.4052 (14.6); 2.8038 (0.8); 1.5674 (16.0); 1.4132 (3.7); 1.3965 (3.7); 0.0080 (0.9); -0.0002 (27.1); -0.0085 (0.7) I.1-438: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6535 (0.8); 8.6474 (1.0); 8.6043 (0.9); 8.5982 (0.7); 8.2556 (1.0); 8.2343 (1.1); 7.7482 (1.0); 7.7270 (1.0); 7.6996 (0.7); 7.3759 (0.6); 7.3739 (0.6); 7.2612 (18.2); 5.4369 (1.8); 2.8038 (4.7); 1.5667 (16.0); 1.4115 (1.6); 1.3948 (1.6); 0.0079 (0.7); -0.0002 (21.0); -0.0085 (0.6) I.1-439: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.1769 (1.4); 9.1544 (1.4); 8.6950 (2.7); 8.6868 (4.4); 8.6654 (4.7); 8.6573 (2.9); 7.9361 (2.4); 7.9322 (2.1); 7.9246 (2.2); 7.9181 (0.9); 7.8967 (2.3); 7.8901 (1.8); 7.8010 (3.5); 7.7733 (2.3); 7.7534 (3.1); 7.7271 (3.5); 7.4555 (3.0); 7.4514 (3.1); 7.2906 (1.9); 7.2860 (1.8); 7.2643 (1.7); 7.2597 (1.7); 5.4338 (0.8); 5.4111 (1.3); 5.3884 (0.8); 3.8511 (15.3); 3.8147 (16.0); 3.3245 (19.7); 2.5158 (6.7); 2.5099 (13.0); 2.5040 (17.2); 2.4980 (11.8); 2.4924 (5.4); 1.4657 (5.0); 1.4428 (5.0); 0.0108 (0.4); -0.0002 (9.5) BCS241005-Ausland STR 187 I.1-440: 1H-NMR(300.1 MHz, d6-DMSO): δ= 12.7371 (0.3); 9.2147 (1.6); 9.1923 (1.6); 8.6895 (2.7); 8.6813 (5.0); 8.6639 (5.1); 8.6559 (3.0); 7.9609 (2.7); 7.9439 (2.0); 7.9375 (1.1); 7.9159 (2.3); 7.9095 (2.0); 7.8099 (4.0); 7.7821 (2.8); 7.7568 (3.2); 7.7306 (3.6); 7.4363 (3.4); 7.4330 (3.5); 7.2885 (2.0); 7.2844 (2.0); 7.2624 (1.8); 7.2582 (1.8); 5.4289 (0.9); 5.4063 (1.4); 5.3835 (0.9); 3.8505 (16.0); 3.3424 (9.5); 2.5107 (7.6); 2.5049 (10.1); 2.4992 (7.2); 1.4637 (5.4); 1.4408 (5.4); -0.0002 (4.7) I.1-441: 1H-NMR(400.1 MHz, d6-DMSO): δ= 9.1301 (1.8); 9.1132 (1.8); 8.6936 (2.8); 8.6876 (4.0); 8.6649 (4.1); 8.6589 (2.8); 8.1023 (3.3); 8.0974 (3.4); 7.8877 (1.6); 7.8827 (1.5); 7.8663 (1.9); 7.8612 (1.8); 7.7575 (3.0); 7.7378 (3.3); 7.6478 (1.7); 7.6278 (1.5); 7.4602 (3.8); 7.2867 (2.2); 7.2671 (2.0); 5.4134 (1.0); 5.3964 (1.6); 5.3792 (1.0); 4.1293 (0.4); 4.1162 (1.0); 4.1030 (1.1); 4.0899 (0.4); 3.8500 (15.9); 3.8152 (16.0); 3.5089 (0.7); 3.3399 (41.0); 3.3163 (0.4); 3.1761 (4.2); 3.1630 (4.1); 2.5045 (27.6); 1.4545 (6.0); 1.4374 (5.9); -0.0002 (2.7) I.1-442: 1H-NMR(300.1 MHz, d6-DMSO): δ= 12.7694 (0.3); 9.1591 (1.6); 9.1368 (1.6); 8.6881 (2.9); 8.6799 (5.2); 8.6628 (5.4); 8.6547 (3.1); 8.1347 (3.6); 8.1277 (3.8); 7.9122 (1.7); 7.9051 (1.6); 7.8835 (2.1); 7.8764 (2.0); 7.7616 (3.3); 7.7355 (3.7); 7.6599 (1.6); 7.6552 (1.7); 7.6312 (1.4); 7.6266 (1.4); 7.4460 (3.3); 7.4420 (3.4); 7.2879 (2.0); 7.2834 (1.9); 7.2618 (1.8); 7.2572 (1.8); 5.4180 (0.9); 5.3952 (1.4); 5.3725 (0.9); 3.8532 (16.0); 3.3418 (3.1); 2.5172 (3.1); 2.5114 (6.1); 2.5055 (8.1); 2.4996 (5.6); 1.4555 (5.3); 1.4327 (5.2); -0.0002 (3.8) I.1-443: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6625 (0.9); 8.6565 (1.2); 8.6153 (1.0); 8.6092 (0.8); 8.2975 (1.1); 8.2762 (1.3); 7.7717 (1.2); 7.7504 (1.2); 7.7076 (0.8); 7.7032 (0.9); 7.6992 (0.6); 7.5791 (0.5); 7.5666 (0.8); 7.5620 (0.5); 7.5581 (0.7); 7.2615 (15.0); 5.7851 (1.3); 5.7793 (1.2); 2.8038 (15.9); 1.5692 (16.0); 1.4240 (1.8); 1.4073 (1.8); 0.0080 (0.5); -0.0002 (18.5) I.1-444: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6760 (2.2); 8.6699 (2.9); 8.6329 (2.8); 8.6269 (2.1); 8.2208 (3.2); 8.2161 (1.0); 8.2042 (1.2); 8.1996 (3.5); 8.0023 (1.6); 7.9986 (2.9); 7.9949 (1.6); 7.8423 (1.5); 7.8380 (2.4); 7.8338 (1.5); 7.7398 (1.8); 7.7354 (3.0); 7.7309 (4.8); 7.7261 (1.2); 7.7141 (1.1); 7.7095 (3.2); 7.4105 (0.6); 7.3905 (0.6); 7.2609 (40.7); 6.0835 (0.6); 6.0673 (0.9); 6.0480 (0.6); 5.9437 (0.7); 5.9280 (0.5); 5.9183 (0.7); 5.9013 (0.9); 5.8853 (0.6); 5.8755 (0.8); 5.8599 (0.6); 5.2276 (1.4); 5.2019 (1.3); 5.0177 (1.2); 4.9739 (1.1); 3.9744 (16.0); 1.5618 (3.6); 0.0079 (1.4); -0.0002 (46.0); -0.0085 (1.4) I.1-445: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6762 (2.0); 8.6701 (2.6); 8.6326 (2.5); 8.6266 (2.0); 8.2207 (3.1); 8.2160 (1.0); 8.2042 (1.1); 8.1994 (3.6); 8.1953 (0.6); 8.0025 (1.5); 7.9988 (2.9); 7.9951 (1.6); 7.8416 (1.4); 7.8373 (2.4); 7.8332 (1.6); 7.7400 (1.6); 7.7356 (2.9); 7.7312 (4.7); 7.7264 (1.2); 7.7144 (1.0); 7.7098 (3.2); 7.4150 (0.6); 7.3953 (0.6); 7.2613 (20.9); 6.0836 (0.5); 6.0675 (0.8); 6.0643 (0.8); BCS241005-Abroad STR 188 6.0479 (0.6); 5.9441 (0.7); 5.9284 (0.5); 5.9187 (0.7); 5.9017 (1.0); 5.8858 (0.6); 5.8759 (0.8); 5.8603 (0.6); 5.2272 (1.3); 5.2018 (1.3); 5.0166 (1.2); 4.9740 (1.1); 3.9742 (16.0); 1.5744 (1.6); 0.0080 (0.6); - 0.0002 (24.1); -0.0085 (0.7) I.1-446: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.2987 (1.6); 9.2769 (1.6); 8.6962 (2.8); 8.6881 (4.4); 8.6666 (4.4); 8.6586 (2.9); 8.3157 (3.9); 8.0906 (4.0); 8.0857 (3.8); 8.0803 (3.9); 8.0747 (4.7); 8.0687 (5.6); 8.0410 (5.0); 7.7930 (4.8); 7.7655 (4.0); 5.3621 (0.9); 5.3400 (1.5); 5.3172 (1.0); 3.3261 (8.6); 2.7288 (0.4); 2.6058 (16.0); 2.5083 (38.9); 2.5026 (51.0); 2.4971 (37.5); 1.5004 (5.5); 1.4775 (5.5); 1.2332 (0.7); 0.0105 (1.2); -0.0002 (24.9) I.1-447: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.2871 (1.5); 9.2653 (1.5); 8.7068 (2.8); 8.6987 (4.3); 8.6722 (4.5); 8.6641 (3.0); 8.3041 (2.1); 8.2993 (3.8); 8.2945 (2.3); 8.0911 (2.0); 8.0844 (4.3); 8.0803 (6.1); 8.0529 (8.2); 8.0468 (2.7); 7.8163 (4.8); 7.7885 (4.0); 5.3575 (0.9); 5.3350 (1.4); 5.3126 (0.9); 3.8830 (15.6); 3.3317 (15.1); 2.6073 (16.0); 2.5157 (7.6); 2.5102 (15.2); 2.5043 (20.3); 2.4984 (14.9); 1.5065 (5.2); 1.4835 (5.2); 0.0107 (0.6); -0.0002 (16.2); -0.0112 (0.7) I.1-448: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.2057 (4.6); 9.1842 (4.8); 8.7083 (7.9); 8.7003 (11.6); 8.6712 (11.7); 8.6632 (8.3); 7.9385 (8.3); 7.9274 (6.9); 7.9067 (8.1); 7.8992 (7.4); 7.8930 (6.0); 7.8805 (9.8); 7.8174 (10.4); 7.8130 (11.3); 7.8007 (10.6); 7.7729 (6.8); 7.7291 (6.0); 7.7245 (5.6); 7.7028 (4.5); 7.6979 (4.3); 5.3448 (0.6); 5.3240 (2.7); 5.3013 (4.2); 5.2791 (2.7); 5.2550 (0.6); 3.3320 (9.5); 2.5103 (20.7); 2.5049 (26.6); 2.0773 (0.8); 1.4911 (16.0); 1.4683 (15.9); 1.2315 (0.9); -0.0002 (10.5) I.1-449: 1H-NMR(300.1 MHz, d6-DMSO): δ= 13.5449 (0.8); 9.1630 (4.7); 9.1412 (4.9); 8.7126 (8.8); 8.7045 (13.1); 8.6750 (13.6); 8.6669 (9.8); 8.1209 (10.2); 8.1139 (10.8); 7.9247 (8.3); 7.8983 (13.4); 7.8728 (6.0); 7.8657 (5.9); 7.8302 (10.8); 7.8253 (11.6); 7.7391 (6.5); 7.7339 (5.8); 7.7126 (4.9); 7.7073 (4.7); 7.6521 (4.8); 7.6475 (5.1); 7.6233 (4.1); 7.6189 (4.0); 5.3368 (0.6); 5.3142 (2.8); 5.2919 (4.3); 5.2694 (2.8); 5.2461 (0.6); 3.3449 (1.6); 2.5153 (9.4); 2.5094 (12.6); 2.5035 (9.0); 2.0824 (1.6); 1.4906 (16.0); 1.4677 (15.8); -0.0001 (3.8) I.1-450: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.1218 (1.7); 9.0995 (1.8); 8.7163 (2.9); 8.7087 (4.0); 8.6749 (4.0); 8.6671 (3.1); 8.2138 (0.4); 8.2066 (0.4); 8.1330 (1.2); 8.0830 (3.5); 8.0768 (3.6); 7.9459 (0.3); 7.9271 (2.7); 7.9005 (3.5); 7.8749 (1.6); 7.8689 (1.6); 7.8391 (6.0); 7.7463 (2.2); 7.7196 (1.7); 7.7149 (1.7); 7.6410 (1.9); 7.6143 (1.6); 5.3359 (0.4); 5.3141 (1.0); 5.2918 (1.6); 5.2684 (1.0); 3.9637 (2.1); 3.8930 (16.0); 3.3261 (18.5); 2.5031 (22.1); 1.4879 (6.2); 1.4653 (6.9); 1.4431 (1.1); 1.2326 (0.4); - 0.0002 (6.4) ``` BCS241005-Ausland STR 189 I.1-451: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.1887 (1.7); 9.1672 (1.7); 8.7196 (3.1); 8.7119 (4.0); 8.6780 (4.2); 8.6702 (3.0); 8.6576 (0.4); 7.9238 (4.6); 7.9094 (3.5); 7.8978 (4.0); 7.8809 (2.7); 7.8748 (2.0); 7.8487 (4.0); 7.8443 (3.9); 7.7988 (3.6); 7.7711 (2.2); 7.7487 (2.4); 7.7439 (2.1); 7.7220 (1.8); 7.7172 (1.6); 5.3308 (1.0); 5.3080 (1.5); 5.2854 (1.0); 3.9618 (0.5); 3.8924 (16.0); 3.3337 (18.4); 3.3099 (0.5); 2.5104 (6.9); 2.5049 (8.6); 1.5351 (0.6); 1.4943 (6.0); 1.4716 (6.0); -0.0001 (3.8) I.1-452: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.0812 (1.7); 9.0588 (1.8); 8.6835 (2.6); 8.6754 (4.4); 8.6559 (4.6); 8.6480 (3.0); 8.2169 (0.5); 8.2100 (0.5); 8.1341 (0.7); 8.0763 (3.5); 8.0695 (3.7); 7.9515 (0.3); 7.9294 (2.2); 7.9010 (2.6); 7.8796 (1.7); 7.8726 (1.6); 7.8509 (2.1); 7.8439 (2.0); 7.6395 (1.9); 7.6103 (1.8); 7.5974 (2.3); 7.5729 (6.5); 5.3584 (1.1); 5.3357 (1.6); 5.3129 (1.0); 3.9660 (1.3); 3.8583 (16.0); 3.8194 (0.4); 3.3322 (6.0); 2.5392 (14.1); 2.5120 (11.0); 2.5065 (14.1); 2.5013 (10.4); 1.5307 (0.6); 1.5075 (0.7); 1.4777 (6.2); 1.4549 (6.2); -0.0001 (5.2) I.1-453: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.1464 (1.8); 9.1240 (1.8); 8.6847 (2.7); 8.6771 (4.3); 8.6575 (4.3); 8.6500 (2.7); 7.9131 (5.6); 7.8958 (3.1); 7.8852 (2.7); 7.7964 (3.2); 7.7692 (2.0); 7.5972 (2.4); 7.5737 (6.6); 5.3727 (1.1); 5.3500 (1.7); 5.3273 (1.1); 3.9635 (0.5); 3.8574 (16.0); 3.3335 (4.1); 2.5389 (14.6); 2.5070 (15.8); 1.4817 (6.4); 1.4590 (6.3); -0.0002 (5.9) I.1-454: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6481 (3.2); 8.6422 (3.9); 8.5980 (3.4); 8.5921 (2.9); 8.2401 (3.7); 8.2195 (4.6); 7.7755 (4.6); 7.7549 (4.1); 7.7249 (3.1); 7.5880 (2.4); 7.3828 (2.2); 7.2622 (17.4); 7.2465 (1.4); 7.2249 (1.2); 5.6236 (0.6); 5.6056 (1.2); 5.5864 (1.1); 5.5683 (0.6); 3.9742 (16.0); 1.8026 (0.6); 1.7845 (1.1); 1.7667 (1.4); 1.7433 (1.5); 1.7249 (1.2); 1.7076 (0.6); 0.7523 (3.6); 0.7345 (6.9); 0.7165 (3.8); -0.0003 (21.2) I.1-455: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6481 (2.9); 8.6422 (3.3); 8.5984 (3.3); 8.5925 (2.6); 8.2404 (3.9); 8.2198 (4.3); 7.7758 (4.3); 7.7552 (4.0); 7.7249 (3.1); 7.5880 (2.4); 7.3828 (2.2); 7.2622 (17.4); 7.2465 (1.4); 7.2249 (1.2); 5.6236 (0.6); 5.6056 (1.2); 5.5864 (1.1); 5.5683 (0.6); 3.9742 (16.0); 1.8026 (0.6); 1.7845 (1.1); 1.7667 (1.4); 1.7433 (1.5); 1.7249 (1.2); 1.7076 (0.6); 0.7528 (3.4); 0.7345 (6.9); 0.7159 (3.2); -0.0002 (21.2) I.1-456: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6444 (2.7); 8.6384 (3.3); 8.5992 (3.2); 8.5933 (2.5); 8.2398 (3.7); 8.2191 (4.1); 7.8720 (2.0); 7.8684 (3.1); 7.8648 (1.8); 7.7732 (4.1); 7.7526 (3.8); 7.6282 (2.0); 7.5355 (1.9); 7.2622 (18.5); 7.2088 (1.0); 7.1878 (1.0); 5.6038 (1.0); 5.5849 (1.0); 5.5669 (0.5); 3.9741 (16.0); 1.7828 (0.9); 1.7644 (1.1); 1.7589 (1.0); 1.7480 (0.9); 1.7405 (1.3); 1.7223 (1.0); 1.7057 (0.5); 1.5702 (1.6); 0.7508 (3.1); 0.7322 (6.6); 0.7137 (3.0); -0.0002 (22.7); -0.0083 (1.3) BCS241005-Ausland STR 190 I.1-457: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6421 (2.9); 8.6375 (3.4); 8.5979 (3.5); 8.5930 (2.7); 8.2384 (4.3); 8.2185 (4.7); 7.8676 (3.6); 7.7714 (4.7); 7.7515 (4.4); 7.6262 (2.9); 7.5349 (2.8); 7.2620 (17.8); 7.2608 (17.9); 7.2018 (1.4); 7.1818 (1.4); 5.6203 (0.7); 5.6032 (1.4); 5.5838 (1.4); 5.5660 (0.6); 3.9732 (16.0); 1.7982 (0.7); 1.7811 (1.2); 1.7638 (1.6); 1.7389 (1.6); 1.7203 (1.2); 1.7029 (0.7); 1.5670 (4.4); 0.7491 (3.9); 0.7308 (7.5); 0.7124 (3.4); -0.0002 (22.6); -0.0014 (22.1) I.1-458: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6842 (2.7); 8.6783 (3.3); 8.6362 (3.3); 8.6302 (2.6); 8.2244 (3.8); 8.2038 (4.2); 7.7314 (4.2); 7.7105 (5.6); 7.7061 (3.7); 7.5683 (2.2); 7.4810 (1.0); 7.4598 (1.0); 7.3794 (2.0); 7.2618 (34.7); 6.0962 (0.7); 6.0794 (1.3); 6.0604 (0.9); 5.9422 (0.7); 5.9263 (0.6); 5.9168 (0.8); 5.9001 (1.2); 5.8836 (0.7); 5.8741 (0.8); 5.8583 (0.7); 5.2327 (1.9); 5.2074 (1.8); 5.0204 (1.8); 4.9779 (1.6); 3.9767 (16.0); 1.5555 (9.9); -0.0002 (43.1); -0.0080 (2.6) I.1-459: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6877 (2.7); 8.6817 (3.2); 8.6363 (3.2); 8.6303 (2.6); 8.2248 (3.7); 8.2042 (4.1); 7.7335 (4.1); 7.7129 (5.6); 7.7094 (3.8); 7.5706 (2.0); 7.5067 (1.0); 7.4874 (1.0); 7.3780 (1.9); 7.2620 (21.0); 6.0978 (0.7); 6.0812 (1.2); 6.0620 (0.8); 5.9461 (0.7); 5.9304 (0.6); 5.9207 (0.8); 5.9040 (1.2); 5.8876 (0.7); 5.8781 (0.8); 5.8623 (0.7); 5.2348 (1.8); 5.2094 (1.7); 5.0216 (1.7); 4.9795 (1.5); 3.9766 (16.0); -0.0002 (25.8); -0.0082 (1.4) I.1-460: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6556 (2.8); 8.6496 (3.2); 8.6000 (3.2); 8.5940 (2.5); 8.2866 (5.0); 8.2389 (3.8); 8.2180 (4.1); 8.0318 (2.2); 7.8376 (4.1); 7.8168 (3.6); 7.4449 (0.9); 7.4249 (1.0); 7.2630 (12.5); 5.1501 (1.0); 5.1292 (1.8); 5.1081 (1.1); 3.9755 (16.0); 1.5983 (2.0); 1.1848 (0.8); 1.1723 (0.6); 1.1638 (0.7); 0.5488 (0.6); 0.5420 (0.5); 0.5272 (0.8); 0.5227 (0.8); 0.5176 (0.7); 0.3821 (0.6); 0.3764 (0.6); 0.3715 (0.8); 0.3616 (1.6); 0.3509 (1.5); 0.3381 (1.3); 0.3254 (0.7); -0.0002 (13.7); -0.0083 (0.8); -0.0445 (0.6); -0.0560 (0.9); -0.0677 (1.0); -0.0780 (0.5) I.1-461: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6567 (3.0); 8.6508 (3.2); 8.6002 (3.4); 8.5943 (2.6); 8.2869 (5.9); 8.2389 (4.1); 8.2184 (4.4); 8.0317 (2.6); 7.8380 (4.4); 7.8174 (4.0); 7.4502 (1.1); 7.4299 (1.1); 7.2629 (14.5); 5.1489 (1.2); 5.1279 (2.1); 5.1071 (1.2); 3.9755 (16.0); 1.5901 (2.0); 1.1979 (0.5); 1.1853 (0.9); 1.1729 (0.7); 1.1647 (0.9); 1.1519 (0.6); 0.5498 (0.7); 0.5425 (0.6); 0.5277 (0.9); 0.5068 (0.5); 0.3716 (0.9); 0.3620 (1.9); 0.3502 (1.8); 0.3384 (1.5); 0.3248 (0.8); -0.0002 (15.9); -0.0344 (0.6); -0.0451 (0.8); -0.0557 (1.0); -0.0680 (1.1) I.1-462: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6408 (2.8); 8.6350 (3.2); 8.5905 (3.3); 8.5847 (2.6); 8.2280 (4.0); 8.2076 (4.4); 7.8246 (4.4); 7.8041 (4.0); 7.7388 (3.1); 7.5965 (2.4); 7.3869 (2.3); 7.2996 (1.1); 7.2791 (1.3); 7.2629 (10.4); 5.1276 (1.2); 5.1067 (2.2); 5.0859 (1.2); 3.9714 (16.0); 1.5907 (2.9); 1.1456 (0.9); 1.1332 (0.7); 1.1251 (0.9); 1.1128 (0.5); 0.5160 (0.7); 0.5086 (0.6); 0.4899 (0.9); 0.4738 (0.5); BCS241005-Abroad STR 191 0.3576 (0.7); 0.3468 (0.9); 0.3378 (1.8); 0.3268 (1.9); 0.3145 (1.5); 0.3028 (0.8); -0.0002 (11.4); -0.0577 (0.7); -0.0700 (1.0); -0.0819 (1.1) I.1-463: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6482 (2.2); 8.6424 (2.5); 8.5926 (2.6); 8.5868 (2.2); 8.2291 (3.6); 8.2084 (4.1); 7.8297 (4.1); 7.8091 (3.6); 7.7472 (1.9); 7.7435 (2.9); 7.7397 (1.8); 7.6000 (2.1); 7.3857 (2.0); 7.3429 (0.9); 7.3237 (1.0); 7.2629 (11.1); 5.1204 (1.0); 5.0996 (1.8); 5.0787 (1.0); 3.9714 (16.0); 1.1503 (0.8); 1.1375 (0.6); 1.1296 (0.8); 0.5209 (0.6); 0.5141 (0.5); 0.4993 (0.8); 0.4951 (0.8); 0.4901 (0.7); 0.3604 (0.5); 0.3495 (0.8); 0.3397 (1.6); 0.3290 (1.5); 0.3163 (1.3); 0.3038 (0.7); -0.0002 (12.3); -0.0083 (0.8); -0.0587 (0.6); -0.0702 (0.8); -0.0818 (0.9); -0.0923 (0.5) I.1-464: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6426 (1.1); 8.6365 (1.3); 8.5932 (1.3); 8.5871 (1.0); 8.2399 (1.5); 8.2191 (1.6); 7.7729 (1.6); 7.7521 (1.5); 7.4919 (1.4); 7.4866 (1.2); 7.2619 (22.4); 7.2306 (0.5); 3.9745 (6.5); 1.7326 (0.5); 1.5585 (16.0); 0.7483 (1.3); 0.7299 (2.7); 0.7113 (1.2); -0.0002 (24.1); -0.0083 (1.2) I.1-465: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6429 (1.3); 8.6372 (1.6); 8.5931 (1.6); 8.5871 (1.2); 8.2395 (1.9); 8.2192 (2.1); 7.7730 (2.0); 7.7525 (2.0); 7.4917 (1.8); 7.4865 (1.7); 7.4675 (0.8); 7.2618 (42.0); 7.2335 (1.1); 7.2107 (0.8); 7.1298 (0.6); 7.1104 (0.6); 5.6114 (0.6); 5.5943 (0.6); 3.9744 (7.9); 1.7806 (0.5); 1.7618 (0.6); 1.7513 (0.6); 1.7329 (0.7); 1.7151 (0.6); 1.5559 (16.0); 0.7486 (1.7); 0.7301 (3.4); 0.7115 (1.6); 0.0302 (0.5); -0.0002 (45.6); - 0.0081 (2.7) I.1-466: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6398 (1.7); 8.6339 (2.0); 8.5859 (1.9); 8.5799 (1.6); 8.2283 (2.3); 8.2078 (2.6); 7.8241 (2.6); 7.8036 (2.3); 7.5039 (2.1); 7.4993 (2.1); 7.4807 (0.8); 7.3020 (0.7); 7.2801 (0.8); 7.2622 (19.6); 7.1328 (0.7); 7.1121 (0.7); 5.1385 (0.7); 5.1173 (1.3); 5.0966 (0.7); 3.9716 (9.5); 1.5638 (16.0); 1.1404 (0.5); 1.1194 (0.5); 0.4889 (0.5); 0.3253 (1.2); 0.3125 (0.9); -0.0002 (21.5); - 0.0082 (1.3); -0.0723 (0.6); -0.0856 (0.6) I.1-467: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6430 (2.4); 8.6372 (2.8); 8.5872 (3.0); 8.5814 (2.4); 8.2290 (3.8); 8.2083 (4.3); 7.8266 (4.2); 7.8059 (3.8); 7.5060 (3.4); 7.5014 (3.5); 7.4832 (1.4); 7.3187 (1.0); 7.2976 (1.2); 7.2622 (33.7); 7.1341 (1.1); 7.1121 (1.2); 5.1356 (1.1); 5.1148 (2.0); 5.0938 (1.1); 3.9717 (16.0); 1.5694 (3.7); 1.1424 (0.8); 1.1305 (0.7); 1.1221 (0.9); 1.1095 (0.5); 0.5135 (0.6); 0.4908 (0.8); 0.4714 (0.5); 0.3351 (1.4); 0.3264 (2.0); 0.3126 (1.5); 0.3035 (0.7); -0.0002 (37.1); -0.0490 (0.6); -0.0599 (0.7); -0.0715 (1.0); -0.0854 (1.1) BCS241005-Ausland STR 192 I.1-468: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6402 (0.7); 8.6342 (0.9); 8.5911 (0.9); 8.5851 (0.7); 8.2275 (1.0); 8.2069 (1.2); 7.8853 (0.8); 7.8229 (1.1); 7.8023 (1.0); 7.6376 (0.6); 7.5382 (0.6); 7.2617 (16.9); 5.1005 (0.6); 3.9713 (4.3); 1.5567 (16.0); -0.0002 (18.3) I.1-469: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6408 (2.5); 8.6349 (2.9); 8.5914 (3.0); 8.5854 (2.4); 8.2280 (3.8); 8.2074 (4.2); 7.8912 (2.1); 7.8876 (3.1); 7.8839 (1.8); 7.8246 (4.2); 7.8040 (3.7); 7.6404 (2.1); 7.5387 (2.0); 7.2962 (0.9); 7.2630 (15.7); 5.1196 (1.1); 5.0987 (2.0); 5.0779 (1.1); 3.9715 (16.0); 1.5873 (13.1); 1.1478 (0.8); 1.1351 (0.6); 1.1271 (0.8); 0.5187 (0.6); 0.5117 (0.5); 0.4971 (0.8); 0.4929 (0.8); 0.4872 (0.7); 0.3588 (0.5); 0.3482 (0.8); 0.3387 (1.6); 0.3258 (1.5); 0.3146 (1.3); 0.3017 (0.7); -0.0002 (16.9); -0.0081 (1.0); -0.0595 (0.6); -0.0709 (0.9); -0.0825 (1.0); -0.0928 (0.6) I.1-470: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6572 (2.1); 8.6512 (2.5); 8.6077 (2.6); 8.6016 (2.0); 8.2692 (3.7); 8.2514 (3.4); 8.2466 (1.2); 8.2348 (1.4); 8.2301 (3.6); 8.2259 (0.6); 8.0286 (1.6); 7.7852 (3.6); 7.7804 (1.2); 7.7686 (1.3); 7.7639 (3.1); 7.7597 (0.5); 7.3396 (0.7); 7.3189 (0.7); 7.2627 (19.2); 5.6499 (0.8); 5.6314 (0.7); 3.9783 (16.0); 1.8153 (0.9); 1.7990 (1.4); 1.7805 (1.6); 1.7622 (0.9); 1.5820 (6.3); 0.7722 (2.7); 0.7537 (5.7); 0.7351 (2.4); 0.0080 (1.1); -0.0002 (21.8); -0.0085 (0.8) I.1-471: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6578 (2.7); 8.6519 (3.2); 8.6074 (3.2); 8.6015 (2.6); 8.2686 (5.8); 8.2509 (4.1); 8.2303 (4.4); 8.0282 (2.5); 7.7850 (4.3); 7.7644 (4.0); 7.3436 (1.1); 7.3231 (1.2); 7.2622 (28.7); 5.6673 (0.6); 5.6493 (1.2); 5.6300 (1.1); 5.6117 (0.6); 3.9782 (16.0); 1.8345 (0.6); 1.8159 (1.2); 1.7990 (2.0); 1.7813 (2.2); 1.7631 (1.4); 1.7467 (0.6); 1.5694 (8.6); 0.7727 (3.5); 0.7541 (6.9); 0.7355 (3.1); 0.0694 (0.6); -0.0002 (31.7); -0.0083 (1.7) I.1-472: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6675 (2.6); 8.6614 (3.1); 8.6034 (2.7); 8.5973 (2.2); 8.2519 (1.5); 8.2483 (2.7); 8.2447 (1.8); 8.2413 (3.3); 8.2365 (1.0); 8.2247 (1.2); 8.2200 (3.5); 8.2158 (0.5); 7.9881 (1.4); 7.9860 (1.2); 7.9297 (1.3); 7.9277 (1.4); 7.7464 (0.6); 7.7422 (3.5); 7.7375 (1.1); 7.7257 (1.1); 7.7210 (3.2); 7.4850 (0.6); 7.4655 (0.6); 7.2627 (10.0); 5.6958 (0.7); 5.6785 (0.8); 5.6598 (0.6); 4.1308 (1.0); 4.1130 (1.0); 3.9773 (16.0); 3.1289 (15.2); 2.0455 (4.8); 1.6587 (0.6); 1.4440 (5.1); 1.4272 (5.1); 1.2774 (1.4); 1.2596 (2.8); 1.2417 (1.3); 0.9009 (6.2); 0.0079 (0.6); -0.0002 (15.4) I.1-473: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6215 (2.2); 8.6154 (3.0); 8.5883 (2.6); 8.5822 (1.8); 8.2263 (2.8); 8.2215 (0.9); 8.2097 (1.0); 8.2050 (3.3); 7.7812 (0.5); 7.7771 (3.1); 7.7723 (1.0); 7.7605 (0.9); 7.7558 (2.9); 7.4040 (3.1); 7.2617 (5.5); 7.2096 (0.5); 7.1312 (1.4); 5.6922 (0.6); 5.6752 (0.7); 5.6725 (0.7); 5.6555 (0.6); 3.9674 (14.8); 2.3579 (16.0); 2.0448 (1.0); 1.4164 (4.9); 1.3996 (4.9); 1.2591 (0.6); - 0.0002 (8.4) BCS241005-Ausland STR 193 I.1-478: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6497 (2.5); 8.6436 (3.0); 8.5862 (2.6); 8.5801 (2.2); 8.2333 (3.1); 8.2287 (1.0); 8.2168 (1.0); 8.2121 (3.5); 8.2079 (0.5); 7.8096 (1.0); 7.8059 (1.4); 7.8022 (1.1); 7.7468 (0.5); 7.7426 (3.3); 7.7380 (1.1); 7.7261 (1.0); 7.7214 (3.1); 7.6799 (1.1); 7.6749 (1.0); 7.6590 (1.5); 7.6541 (1.5); 7.5647 (2.8); 7.5439 (2.0); 7.3579 (0.5); 7.3382 (0.5); 7.2613 (17.6); 5.6805 (0.6); 5.6632 (0.8); 5.6442 (0.7); 3.9733 (16.0); 1.5725 (7.9); 1.4145 (5.2); 1.3977 (5.2); 0.0080 (0.7); -0.0002 (23.5); -0.0084 (0.7) I.1-479: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6495 (2.6); 8.6434 (3.1); 8.5900 (2.6); 8.5839 (2.2); 8.2331 (3.1); 8.2284 (1.0); 8.2166 (1.1); 8.2118 (3.5); 8.2076 (0.5); 7.9404 (2.4); 7.9350 (2.5); 7.7570 (1.3); 7.7516 (1.3); 7.7449 (0.6); 7.7407 (3.5); 7.7358 (2.5); 7.7302 (1.5); 7.7242 (1.1); 7.7195 (3.1); 7.4046 (1.0); 7.4010 (1.0); 7.3833 (0.9); 7.3797 (0.9); 7.3480 (0.6); 7.3284 (0.6); 7.2621 (9.1); 5.6756 (0.7); 5.6585 (0.8); 5.6565 (0.8); 5.6394 (0.6); 3.9739 (16.0); 2.1720 (0.5); 1.5890 (8.0); 1.4110 (5.2); 1.3943 (5.2); -0.0002 (11.3) I.1-480: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7090 (2.8); 8.7029 (3.2); 8.6282 (3.0); 8.6221 (2.6); 8.3096 (1.6); 8.3059 (3.0); 8.3022 (2.1); 8.2978 (3.3); 8.2932 (1.1); 8.2813 (1.2); 8.2766 (3.8); 8.0231 (1.5); 8.0210 (1.4); 7.9360 (1.5); 7.7926 (3.5); 7.7881 (1.1); 7.7760 (1.2); 7.7715 (3.8); 7.7488 (0.9); 7.2620 (17.7); 5.7410 (0.7); 5.7227 (0.8); 5.7048 (0.7); 3.1551 (0.7); 3.1320 (16.0); 1.5149 (4.7); 1.4981 (4.7); 1.2422 (1.2); 1.2392 (0.6); 0.9008 (0.8); 0.0080 (0.6); -0.0002 (26.8); -0.0085 (0.9) I.1-481: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6583 (2.2); 8.6523 (2.8); 8.6198 (2.6); 8.6137 (1.9); 8.2327 (2.7); 8.2283 (0.9); 8.2162 (1.0); 8.2117 (3.0); 7.7664 (3.0); 7.7619 (0.9); 7.7498 (0.9); 7.7454 (2.7); 7.5261 (0.7); 7.5063 (0.7); 7.4552 (3.2); 7.2611 (9.8); 7.1479 (1.4); 5.7936 (0.6); 5.7765 (0.7); 5.7569 (0.6); 4.1321 (0.6); 4.1143 (0.6); 2.3672 (16.0); 2.0468 (2.8); 1.5099 (4.2); 1.4932 (4.2); 1.2778 (0.8); 1.2600 (1.6); 1.2420 (0.9); 0.9008 (1.9); -0.0002 (14.9); -0.0085 (0.5) I.1-482: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6493 (2.6); 8.6433 (3.1); 8.5857 (2.6); 8.5797 (2.2); 8.2327 (3.2); 8.2280 (1.0); 8.2163 (1.1); 8.2115 (3.4); 8.2073 (0.6); 7.7378 (3.4); 7.7332 (1.1); 7.7213 (1.0); 7.7166 (3.1); 7.7045 (1.1); 7.6992 (1.2); 7.6787 (1.0); 7.6736 (1.2); 7.6302 (0.7); 7.6270 (0.8); 7.6222 (0.6); 7.6090 (0.8); 7.6057 (0.9); 7.6009 (0.7); 7.4026 (0.5); 7.3841 (0.9); 7.3627 (1.0); 7.3428 (0.6); 7.2608 (27.6); 5.6778 (0.7); 5.6586 (0.8); 5.6415 (0.7); 3.9742 (16.0); 1.5543 (13.9); 1.4059 (5.4); 1.3892 (5.3); 0.0080 (1.0); -0.0002 (35.7); -0.0085 (1.1) I.1-483: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6830 (0.5); 8.6769 (0.9); 8.6608 (1.0); 8.6547 (0.6); 8.0613 (0.8); 8.0402 (1.0); 7.9167 (0.8); 7.7954 (0.6); 7.7884 (0.9); 7.7741 (0.5); 7.7673 (0.8); 3.3257 (16.0); 2.5115 (7.0); 2.5070 (15.3); 2.5024 (21.4); 2.4978 (14.9); 2.4932 (6.6); 1.9891 (2.1); 1.4741 (1.0); 1.4569 (1.0); 1.1927 (0.6); 1.1749 (1.2); 1.1572 (0.6); -0.0002 (12.8) BCS241005-Ausland STR 194 I.1-485: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1211 (1.6); 9.1047 (1.6); 8.6866 (3.7); 8.6805 (5.7); 8.6610 (6.3); 8.6549 (4.2); 8.0706 (5.1); 8.0660 (1.6); 8.0542 (1.8); 8.0495 (6.2); 8.0454 (0.9); 7.8886 (0.8); 7.8838 (0.8); 7.8102 (9.7); 7.8054 (13.2); 7.7845 (6.0); 7.7805 (5.2); 7.7758 (4.8); 7.7710 (2.3); 7.7681 (1.8); 7.7634 (5.1); 7.7592 (0.7); 5.3142 (1.1); 5.2974 (1.6); 5.2805 (1.1); 4.0570 (0.6); 4.0392 (1.8); 4.0215 (1.8); 4.0037 (0.6); 3.3305 (16.0); 2.5269 (0.9); 2.5222 (1.3); 2.5134 (16.7); 2.5089 (35.8); 2.5043 (49.3); 2.4997 (33.7); 2.4952 (14.7); 1.9902 (8.2); 1.4696 (6.4); 1.4524 (6.4); 1.3566 (1.3); 1.2325 (0.6); 1.1934 (2.3); 1.1822 (0.7); 1.1757 (4.7); 1.1704 (0.5); 1.1579 (2.3); 0.8879 (3.3); 0.0080 (0.8); - 0.0002 (28.8); -0.0085 (0.8) I.1-486: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6739 (0.8); 8.6592 (0.9); 8.6531 (0.6); 8.0704 (0.7); 8.0492 (0.9); 7.7928 (0.8); 7.7717 (0.8); 4.0382 (0.5); 4.0205 (0.5); 3.3256 (16.0); 2.5113 (6.2); 2.5068 (13.7); 2.5023 (19.1); 2.4977 (13.2); 2.4931 (5.9); 1.9890 (2.5); 1.4676 (0.9); 1.4504 (0.9); 1.1927 (0.7); 1.1749 (1.4); 1.1571 (0.7); -0.0002 (11.9) I.1-487: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6720 (0.9); 8.6660 (1.2); 8.6211 (1.0); 8.6150 (0.8); 8.2199 (1.2); 8.1986 (1.3); 7.9062 (0.9); 7.9011 (0.9); 7.7352 (1.2); 7.7139 (1.2); 7.6347 (0.6); 7.6295 (0.6); 7.5328 (1.1); 7.5121 (0.8); 7.2612 (13.9); 3.9743 (6.0); 1.5592 (16.0); 0.0079 (0.5); -0.0002 (15.7) I.1-488: 1H-NMR(400.6 MHz, CDCl3): δ= 8.5894 (0.7); 8.5833 (0.6); 8.2396 (0.9); 8.2184 (1.0); 8.0014 (2.3); 7.9795 (2.4); 7.9393 (0.6); 7.9342 (0.6); 7.8018 (0.8); 7.7807 (0.7); 7.5310 (0.8); 7.5102 (0.6); 7.2610 (13.6); 7.2461 (1.1); 7.2431 (1.1); 7.2244 (1.1); 7.2212 (1.0); 3.9703 (4.7); 2.8933 (16.0); 2.8392 (1.9); 2.8207 (6.1); 2.8022 (6.2); 2.7838 (2.0); 1.2094 (6.6); 1.1910 (13.4); 1.1725 (6.4); 0.7633 (0.6); 0.7449 (1.4); 0.7264 (0.6); -0.0002 (15.4) I.1-489: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6316 (1.0); 8.6256 (1.3); 8.5837 (1.1); 8.5776 (0.8); 8.2349 (1.2); 8.2137 (1.4); 7.9237 (1.0); 7.9186 (1.0); 7.7773 (1.3); 7.7561 (1.2); 7.6484 (0.6); 7.6432 (0.6); 7.5426 (1.2); 7.5218 (0.8); 7.2611 (14.1); 3.9717 (6.3); 1.5590 (16.0); 0.7437 (1.0); 0.7252 (2.2); 0.7066 (1.0); -0.0002 (16.2) I.1-490: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6290 (0.6); 8.6229 (0.8); 8.5764 (0.6); 8.2236 (0.8); 8.2023 (0.9); 7.9354 (0.6); 7.9302 (0.7); 7.8288 (0.9); 7.8076 (0.8); 7.5470 (0.8); 7.5262 (0.6); 7.2605 (27.0); 3.9690 (4.3); 1.5455 (16.0); 0.0079 (1.0); -0.0002 (31.6); -0.0085 (0.8) I.1-491: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6302 (1.6); 8.6242 (1.9); 8.5767 (1.4); 8.5710 (1.2); 8.2236 (3.0); 8.2189 (1.0); 8.2071 (1.1); 8.2023 (3.6); 8.1982 (0.6); 7.9360 (2.4); 7.9308 (2.5); 7.8298 (3.3); 7.8250 (1.1); 7.8132 (1.0); 7.8085 (3.1); 7.6809 (1.2); 7.6757 (1.1); 7.6601 (1.6); 7.6549 (1.6); 7.5463 BCS241005-Foreign STR 195 (2.9); 7.5255 (2.1); 7.2609 (43.6); 5.1342 (0.8); 5.1134 (1.5); 5.0927 (0.8); 3.9689 (16.0); 2.6182 (0.5); 1.5722 (1.3); 1.2550 (0.8); 1.1384 (0.6); 1.1175 (0.6); 0.4811 (0.5); 0.4759 (0.5); 0.4717 (0.5); 0.3394 (0.6); 0.3350 (0.7); 0.3295 (0.9); 0.3256 (0.6); 0.3201 (1.3); 0.3096 (0.9); 0.3061 (1.0); 0.0080 (1.6); - 0.0002 (51.1); -0.0085 (1.5); -0.0658 (0.5); -0.0803 (0.6) I.1-493: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6498 (2.1); 8.6437 (2.5); 8.5854 (2.1); 8.5793 (1.8); 8.2545 (2.4); 8.2498 (0.8); 8.2380 (0.8); 8.2332 (2.8); 7.8134 (0.8); 7.8096 (1.2); 7.8059 (0.9); 7.7445 (2.6); 7.7399 (0.8); 7.7279 (0.8); 7.7233 (2.5); 7.6824 (0.9); 7.6774 (0.8); 7.6615 (1.3); 7.6565 (1.2); 7.5651 (2.3); 7.5443 (1.6); 7.3491 (0.5); 7.2636 (8.0); 5.6820 (0.5); 5.6631 (0.6); 5.6458 (0.5); 4.5538 (1.3); 4.5419 (1.4); 4.5389 (1.1); 4.5297 (1.5); 3.8887 (1.6); 3.8765 (1.7); 3.8645 (1.5); 3.7411 (1.6); 3.7330 (1.4); 3.7300 (1.9); 3.7252 (1.4); 3.7180 (2.3); 3.6078 (2.3); 3.6007 (1.4); 3.5957 (1.9); 3.5929 (1.4); 3.5846 (1.5); 3.4047 (16.0); 1.6156 (6.4); 1.4123 (4.0); 1.3955 (4.0); -0.0002 (9.8) I.1-494: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6504 (2.1); 8.6444 (2.6); 8.5897 (2.2); 8.5837 (1.8); 8.2543 (2.6); 8.2497 (0.8); 8.2378 (0.9); 8.2331 (2.9); 7.9425 (2.0); 7.9372 (2.1); 7.7587 (1.1); 7.7533 (1.0); 7.7415 (2.9); 7.7373 (2.0); 7.7319 (1.3); 7.7250 (0.9); 7.7204 (2.6); 7.4059 (0.8); 7.4023 (0.8); 7.3845 (0.7); 7.3809 (0.7); 7.3506 (0.6); 7.3312 (0.6); 7.2628 (10.4); 5.6774 (0.6); 5.6585 (0.6); 5.6411 (0.6); 4.5549 (1.4); 4.5430 (1.5); 4.5399 (1.2); 4.5307 (1.5); 3.8896 (1.6); 3.8774 (1.8); 3.8654 (1.5); 3.7416 (1.6); 3.7335 (1.4); 3.7306 (2.0); 3.7257 (1.4); 3.7185 (2.4); 3.6081 (2.4); 3.6010 (1.4); 3.5961 (1.9); 3.5933 (1.4); 3.5850 (1.6); 3.4052 (16.0); 1.5937 (8.2); 1.4084 (4.2); 1.3917 (4.2); -0.0002 (12.7) I.1-495: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6514 (2.1); 8.6453 (2.6); 8.6019 (2.2); 8.5959 (1.8); 8.2524 (2.6); 8.2478 (0.8); 8.2359 (0.9); 8.2312 (2.8); 7.7366 (2.8); 7.7319 (0.8); 7.7200 (0.9); 7.7154 (2.5); 7.6742 (4.8); 7.6695 (5.0); 7.4990 (1.3); 7.4943 (2.4); 7.4896 (1.2); 7.2626 (10.4); 5.6618 (0.5); 5.6448 (0.6); 5.6254 (0.5); 4.5543 (1.3); 4.5425 (1.5); 4.5392 (1.1); 4.5301 (1.5); 3.8893 (1.6); 3.8771 (1.7); 3.8651 (1.5); 3.7416 (1.6); 3.7334 (1.4); 3.7305 (2.0); 3.7256 (1.4); 3.7185 (2.4); 3.6080 (2.4); 3.6008 (1.4); 3.5960 (1.9); 3.5931 (1.4); 3.5849 (1.6); 3.4052 (16.0); 1.5872 (6.2); 1.4071 (4.1); 1.3904 (4.1); - 0.0002 (13.5) I.1-496: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6489 (1.7); 8.6429 (2.1); 8.5875 (1.8); 8.5814 (1.5); 8.2538 (2.0); 8.2492 (0.7); 8.2373 (0.7); 8.2326 (2.4); 7.7518 (0.5); 7.7438 (2.3); 7.7357 (0.6); 7.7302 (0.6); 7.7273 (0.8); 7.7227 (2.2); 7.2992 (0.9); 7.2763 (1.1); 7.2615 (20.7); 7.2544 (0.8); 5.6628 (0.5); 4.5537 (1.1); 4.5418 (1.2); 4.5387 (1.0); 4.5296 (1.2); 3.8886 (1.3); 3.8764 (1.4); 3.8644 (1.2); 3.7410 (1.3); 3.7328 (1.1); 3.7298 (1.6); 3.7250 (1.2); 3.7178 (2.0); 3.6076 (1.9); 3.6004 (1.1); 3.5956 (1.6); 3.5927 (1.2); 3.5845 (1.3); 3.4049 (13.2); 1.5690 (9.6); 1.5668 (16.0); 1.4108 (3.4); 1.3941 (3.4); 0.0079 (0.7); -0.0002 (25.9); -0.0085 (0.7) BCS241005-Ausland STR 196 I.1-497: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6503 (0.9); 8.6442 (1.1); 8.5847 (1.0); 8.5787 (0.8); 8.2536 (1.1); 8.2324 (1.3); 7.7383 (1.2); 7.7173 (1.2); 7.2612 (17.1); 4.5546 (0.6); 4.5426 (0.7); 4.5304 (0.7); 3.8893 (0.7); 3.8770 (0.8); 3.8650 (0.7); 3.7412 (0.7); 3.7332 (0.6); 3.7301 (0.9); 3.7254 (0.6); 3.7181 (1.0); 3.6078 (1.0); 3.6007 (0.6); 3.5957 (0.8); 3.5930 (0.6); 3.5846 (0.7); 3.4052 (7.0); 1.5581 (16.0); 1.4035 (1.8); 1.3868 (1.8); 0.0080 (0.6); -0.0002 (21.1); -0.0084 (0.6) I.1-498: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6312 (2.4); 8.6252 (3.3); 8.5899 (2.8); 8.5839 (2.1); 8.2262 (3.0); 8.2215 (1.0); 8.2097 (1.0); 8.2049 (3.4); 8.2007 (0.6); 7.8364 (2.3); 7.8309 (2.6); 7.7609 (0.6); 7.7568 (3.3); 7.7520 (1.2); 7.7483 (1.4); 7.7426 (1.3); 7.7405 (1.2); 7.7356 (3.1); 7.7313 (0.6); 7.7269 (1.3); 7.7213 (1.2); 7.2629 (8.4); 7.2252 (0.6); 7.2060 (0.6); 6.9695 (2.0); 6.9479 (1.9); 5.6753 (0.6); 5.6582 (0.7); 5.6559 (0.7); 5.6389 (0.6); 3.9693 (16.0); 3.9511 (14.4); 2.0454 (1.0); 1.6093 (2.4); 1.4070 (5.1); 1.3902 (5.1); 1.2772 (0.5); 1.2638 (0.9); 1.2595 (1.2); 0.9007 (1.0); 0.8818 (1.5); 0.8640 (0.6); - 0.0002 (11.1) I.1-499: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6358 (2.5); 8.6297 (3.1); 8.5817 (2.7); 8.5756 (2.2); 8.2324 (3.2); 8.2279 (1.1); 8.2160 (1.1); 8.2112 (3.7); 7.7670 (0.6); 7.7627 (3.6); 7.7581 (1.2); 7.7462 (1.1); 7.7416 (3.4); 7.7374 (0.5); 7.4806 (2.2); 7.4759 (2.3); 7.4234 (2.1); 7.4031 (2.7); 7.3234 (0.6); 7.3034 (0.6); 7.2659 (1.9); 7.2635 (7.4); 7.2457 (1.2); 7.2409 (1.2); 5.6881 (0.7); 5.6691 (0.8); 5.6518 (0.7); 3.9711 (16.0); 3.9528 (13.9); 2.0452 (0.8); 1.6266 (1.2); 1.4162 (5.5); 1.3994 (5.4); -0.0002 (5.4) I.1-500: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9686 (1.3); 8.9521 (1.3); 8.6737 (2.6); 8.6676 (4.2); 8.6499 (4.7); 8.6438 (3.1); 8.0682 (3.5); 8.0471 (4.3); 7.8005 (3.5); 7.7796 (3.0); 7.4950 (2.4); 7.4900 (3.3); 7.4686 (4.6); 7.4523 (2.7); 7.4479 (2.1); 7.4318 (0.9); 7.4274 (0.8); 5.3347 (0.8); 5.3176 (1.2); 5.3007 (0.8); 3.8892 (16.0); 3.3205 (15.9); 2.6747 (0.8); 2.6700 (1.2); 2.6655 (0.8); 2.5239 (3.8); 2.5191 (5.3); 2.5103 (68.2); 2.5058 (144.1); 2.5013 (197.9); 2.4967 (135.7); 2.4921 (59.3); 2.3328 (0.8); 2.3284 (1.2); 2.3237 (0.8); 1.4665 (4.7); 1.4492 (4.7); 0.1457 (0.6); 0.0281 (0.6); 0.0080 (5.7); -0.0002 (178.9); - 0.0085 (4.7); -0.1493 (0.6) I.1-501: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8524 (1.1); 8.8361 (1.2); 8.6693 (2.1); 8.6633 (3.1); 8.6430 (3.3); 8.6369 (2.2); 8.0735 (3.0); 8.0527 (3.6); 7.9476 (2.4); 7.9422 (2.5); 7.8154 (1.4); 7.8066 (3.7); 7.7938 (1.6); 7.7860 (3.2); 7.1876 (2.1); 7.1657 (1.9); 5.2993 (0.7); 5.2826 (1.1); 5.2657 (0.7); 3.8972 (11.8); 3.3247 (16.0); 2.5246 (1.3); 2.5110 (23.0); 2.5067 (46.1); 2.5023 (61.2); 2.4978 (43.5); 2.4935 (20.3); 1.4454 (4.0); 1.4282 (4.0); 0.0079 (1.6); -0.0002 (39.0); -0.0084 (1.5) I.1-513: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6494 (1.2); 8.6437 (1.4); 8.5887 (1.6); 8.5828 (1.3); 8.2331 (3.1); 8.2287 (1.0); 8.2166 (1.0); 8.2121 (3.4); 7.8254 (0.7); 7.8073 (0.7); 7.7629 (0.6); 7.7573 (0.6); 7.7520 (0.8); 7.7441 (3.5); 7.7360 (0.8); 7.7303 (0.9); 7.7233 (3.2); 7.3331 (0.6); 7.3136 (0.6); 7.2979 BCS241005-Abroad STR 197 (1.3); 7.2752 (1.7); 7.2616 (15.4); 7.2531 (1.2); 5.6785 (0.7); 5.6612 (0.8); 5.6423 (0.7); 5.3002 (10.5); 3.9732 (16.0); 1.5789 (1.9); 1.4144 (5.5); 1.3976 (5.5); 0.0080 (0.6); -0.0002 (19.1) I.1-514: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6443 (1.1); 8.5888 (1.4); 8.5832 (1.2); 8.2331 (3.1); 8.2288 (1.0); 8.2165 (1.1); 8.2121 (3.4); 7.8257 (0.8); 7.8077 (0.8); 7.7633 (0.7); 7.7578 (0.6); 7.7525 (0.8); 7.7443 (3.6); 7.7365 (0.9); 7.7309 (1.0); 7.7235 (3.2); 7.3341 (0.6); 7.3139 (0.6); 7.2980 (1.3); 7.2753 (1.7); 7.2619 (12.9); 7.2531 (1.2); 5.6784 (0.7); 5.6613 (0.8); 5.6423 (0.7); 5.3002 (10.3); 3.9732 (16.0); 1.5934 (1.5); 1.4146 (5.6); 1.3979 (5.5); -0.0002 (15.8) I.1-515: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6813 (0.5); 8.6752 (0.9); 8.6585 (1.0); 8.6524 (0.6); 8.0623 (0.7); 8.0412 (1.0); 7.7916 (0.8); 7.7705 (0.8); 5.7569 (4.0); 3.3234 (16.0); 2.5200 (0.5); 2.5112 (7.4); 2.5066 (16.2); 2.5021 (22.5); 2.4975 (15.6); 2.4929 (6.9); 1.4718 (1.0); 1.4546 (1.0); 1.3554 (0.6); 1.1810 (0.5); 0.8892 (0.6); 0.0080 (0.5); -0.0002 (18.3) I.1-516: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0955 (0.8); 9.0791 (0.8); 8.6814 (1.8); 8.6753 (2.9); 8.6585 (3.3); 8.6524 (2.1); 8.0622 (2.6); 8.0575 (0.8); 8.0456 (0.9); 8.0409 (3.2); 7.9858 (0.6); 7.9667 (1.1); 7.9614 (0.6); 7.9549 (0.7); 7.9449 (0.6); 7.9334 (0.6); 7.7914 (2.8); 7.7867 (0.9); 7.7749 (0.8); 7.7702 (2.6); 7.6134 (0.9); 7.5916 (0.9); 7.5881 (1.0); 7.5665 (0.8); 5.7573 (6.3); 5.3307 (0.5); 5.3136 (0.8); 5.2969 (0.5); 3.3209 (16.0); 2.5245 (0.9); 2.5199 (1.4); 2.5111 (24.9); 2.5066 (54.2); 2.5020 (75.3); 2.4974 (51.8); 2.4928 (23.0); 1.9936 (1.3); 1.9890 (1.3); 1.9091 (1.4); 1.4718 (3.2); 1.4546 (3.2); 1.3555 (1.5); 1.1811 (1.6); 1.1748 (0.9); 0.8892 (1.5); 0.8849 (0.6); 0.0079 (1.8); -0.0002 (63.4); -0.0060 (0.6); - 0.0069 (0.5); -0.0085 (1.7) I.1-517: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7599 (2.6); 8.6492 (6.6); 8.6432 (8.9); 8.6267 (2.1); 8.6045 (7.1); 8.5984 (5.5); 8.2527 (7.8); 8.2481 (2.6); 8.2361 (2.7); 8.2315 (8.7); 8.2275 (1.4); 7.9173 (1.3); 7.9125 (1.4); 7.8535 (1.8); 7.8337 (1.9); 7.7479 (8.3); 7.7433 (2.6); 7.7313 (2.6); 7.7268 (7.8); 7.6871 (1.0); 7.6824 (1.0); 7.6643 (15.2); 7.6596 (16.0); 7.5605 (0.7); 7.5231 (0.5); 7.4956 (4.2); 7.4909 (7.5); 7.4862 (3.7); 7.3882 (1.4); 7.3759 (1.5); 7.3689 (1.5); 7.3569 (1.4); 7.2908 (1.7); 7.2718 (1.7); 7.2620 (49.0); 5.6444 (1.7); 5.6273 (2.0); 5.6081 (1.6); 5.4402 (12.6); 5.3871 (1.2); 5.3001 (10.5); 2.1161 (0.5); 2.0456 (1.0); 1.6741 (3.8); 1.4060 (13.0); 1.3893 (12.9); 1.3332 (0.8); 1.2845 (1.1); 1.2773 (0.7); 1.2594 (2.3); 1.2554 (2.6); 1.2419 (0.6); 0.8816 (0.7); 0.0080 (1.8); -0.0002 (58.9); -0.0085 (1.7) I.1-518: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6507 (2.5); 8.6446 (3.2); 8.6030 (2.7); 8.5970 (2.1); 8.2316 (3.2); 8.2269 (1.0); 8.2151 (1.1); 8.2103 (3.4); 7.8203 (1.5); 7.8163 (2.7); 7.8122 (1.6); 7.7351 (3.4); 7.7304 (1.1); 7.7171 (2.3); 7.7136 (5.0); 7.7089 (1.9); 7.6515 (1.7); 7.6470 (2.8); 7.6424 (1.4); 7.2970 (0.5); 7.2772 (0.6); 7.2611 (29.7); 5.6569 (0.7); 5.6398 (0.8); 5.6206 (0.7); 3.9735 (16.0); 1.5618 (11.3); 1.4098 (5.3); 1.3931 (5.3); 0.0080 (1.1); -0.0002 (35.7); -0.0085 (1.0) BCS241005-Ausland STR 198 I.1-519: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6519 (2.4); 8.6459 (3.4); 8.6169 (2.8); 8.6109 (2.0); 8.1524 (2.2); 8.1323 (2.4); 7.8978 (2.4); 7.8927 (2.5); 7.7614 (1.4); 7.7573 (1.4); 7.7413 (1.2); 7.7372 (1.3); 7.6612 (1.2); 7.6580 (1.7); 7.6547 (1.2); 7.6415 (1.2); 7.6363 (1.1); 7.6207 (1.6); 7.6155 (1.6); 7.5313 (2.9); 7.5105 (2.0); 7.2613 (17.9); 7.2128 (0.5); 7.1931 (0.6); 5.6181 (0.7); 5.6008 (0.8); 5.5818 (0.7); 3.9834 (16.0); 1.5652 (9.2); 1.4466 (5.2); 1.4298 (5.1); 0.0079 (0.7); -0.0002 (22.0); -0.0085 (0.6) I.1-520: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6468 (2.4); 8.6428 (3.0); 8.6121 (2.5); 8.6081 (2.0); 8.1452 (2.1); 8.1319 (2.2); 8.0454 (2.3); 8.0420 (2.3); 7.7548 (1.2); 7.7521 (1.3); 7.7415 (1.2); 7.7388 (1.2); 7.6993 (2.0); 7.6855 (2.6); 7.6551 (1.6); 7.5859 (1.4); 7.5824 (1.4); 7.5721 (1.1); 7.5686 (1.1); 7.2654 (0.7); 7.2594 (36.8); 7.1865 (0.5); 7.1734 (0.5); 5.6062 (0.6); 5.5946 (0.8); 5.5820 (0.6); 3.9876 (0.4); 3.9817 (14.3); 1.5423 (27.0); 1.5350 (0.4); 1.4416 (4.7); 1.4304 (4.8); 1.2538 (0.8); 0.0054 (2.0); -0.0001 (50.0); -0.0056 (1.2) I.1-521: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6625 (2.4); 8.6565 (3.4); 8.6289 (3.0); 8.6229 (2.1); 8.1568 (2.3); 8.1367 (2.6); 7.7536 (1.4); 7.7495 (1.5); 7.7335 (1.3); 7.7294 (1.4); 7.7038 (1.5); 7.6998 (2.4); 7.6957 (1.5); 7.6582 (1.3); 7.6551 (1.8); 7.6518 (1.2); 7.5563 (1.5); 7.3773 (1.4); 7.2611 (21.2); 7.2405 (0.6); 7.2210 (0.6); 5.6176 (0.7); 5.6004 (0.8); 5.5815 (0.7); 3.9852 (16.0); 1.5615 (5.7); 1.4541 (5.4); 1.4373 (5.4); 0.0079 (0.9); -0.0002 (26.3); -0.0085 (0.8) I.1-522: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6621 (2.4); 8.6561 (3.4); 8.6296 (2.9); 8.6235 (2.0); 8.1565 (2.2); 8.1364 (2.5); 7.8501 (1.5); 7.8462 (2.6); 7.8423 (1.5); 7.7540 (1.4); 7.7499 (1.4); 7.7339 (1.2); 7.7298 (1.4); 7.6579 (1.2); 7.6547 (1.7); 7.6514 (1.2); 7.5990 (1.4); 7.5968 (1.3); 7.5270 (1.3); 7.2612 (22.0); 7.2298 (0.6); 7.2103 (0.6); 5.6149 (0.7); 5.5978 (0.8); 5.5788 (0.7); 3.9850 (16.0); 1.5621 (1.5); 1.4543 (5.2); 1.4375 (5.2); 0.0079 (0.9); -0.0002 (27.2); -0.0085 (0.7) I.1-523: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6750 (2.0); 8.6689 (2.7); 8.6374 (2.4); 8.6313 (1.7); 8.2407 (2.8); 8.1680 (1.8); 8.1480 (2.1); 8.0210 (1.2); 7.7643 (1.1); 7.7602 (1.2); 7.7442 (1.0); 7.7401 (1.1); 7.6699 (1.0); 7.6666 (1.4); 7.2608 (33.8); 5.6618 (0.6); 5.6431 (0.7); 5.6256 (0.6); 3.9889 (13.2); 1.5538 (16.0); 1.4885 (4.4); 1.4717 (4.3); 0.0080 (1.2); -0.0002 (42.5); -0.0085 (1.2) I.1-524: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6578 (2.4); 8.6518 (3.4); 8.6279 (3.1); 8.6219 (2.1); 8.1542 (2.3); 8.1341 (2.6); 7.7529 (1.4); 7.7488 (1.5); 7.7328 (1.3); 7.7287 (1.4); 7.6646 (6.1); 7.6599 (7.3); 7.5007 (1.6); 7.4960 (2.9); 7.4913 (1.4); 7.2609 (31.0); 7.2092 (0.6); 7.1893 (0.7); 5.6083 (0.7); 5.5908 (0.9); 5.5719 (0.8); 3.9845 (16.0); 1.5563 (7.2); 1.4463 (5.6); 1.4295 (5.6); 0.0079 (1.4); -0.0002 (37.9); -0.0085 (1.2) BCS241005-Ausland STR 199 I.1-525: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6551 (2.4); 8.6491 (3.5); 8.6226 (2.8); 8.6166 (2.0); 8.0912 (2.2); 8.0712 (2.4); 7.8487 (1.4); 7.8448 (2.5); 7.8409 (1.4); 7.6548 (1.4); 7.6507 (1.5); 7.6348 (1.2); 7.6307 (1.4); 7.5995 (1.3); 7.5973 (1.2); 7.5627 (1.6); 7.5268 (1.2); 7.5208 (0.6); 7.2615 (15.0); 7.2313 (0.6); 7.2112 (0.6); 6.9249 (1.3); 6.7396 (2.2); 6.5547 (1.4); 5.6369 (0.6); 5.6199 (0.7); 5.6174 (0.7); 5.6003 (0.6); 3.9751 (16.0); 1.5791 (1.1); 1.4536 (4.9); 1.4368 (4.9); 1.2645 (1.1); 0.8987 (0.6); 0.8819 (2.1); 0.8642 (0.8); 0.0080 (0.5); -0.0002 (17.9); -0.0085 (0.5) I.1-526: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6538 (2.4); 8.6477 (3.4); 8.6219 (2.9); 8.6158 (2.0); 8.0912 (2.2); 8.0712 (2.4); 7.7019 (1.4); 7.6979 (2.3); 7.6938 (1.5); 7.6532 (1.4); 7.6491 (1.5); 7.6332 (1.3); 7.6291 (1.4); 7.5591 (2.6); 7.3826 (0.7); 7.3802 (1.0); 7.3777 (1.2); 7.3755 (1.2); 7.2614 (16.9); 7.2293 (0.6); 7.2095 (0.6); 6.9255 (1.3); 6.7403 (2.2); 6.5553 (1.4); 5.6395 (0.6); 5.6226 (0.7); 5.6199 (0.7); 5.6028 (0.6); 3.9754 (16.0); 1.5712 (11.7); 1.4522 (5.1); 1.4355 (5.0); 1.2645 (1.2); 0.8987 (0.6); 0.8820 (2.0); 0.8642 (0.8); 0.0079 (0.6); -0.0002 (20.6); -0.0085 (0.6) I.1-527: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6664 (2.4); 8.6604 (3.4); 8.6303 (2.8); 8.6243 (2.1); 8.2397 (3.4); 8.1027 (2.2); 8.0827 (2.4); 8.0207 (1.5); 7.6668 (1.4); 7.6627 (1.5); 7.6468 (1.2); 7.6427 (1.4); 7.5749 (1.7); 7.3523 (0.6); 7.3327 (0.6); 7.2614 (16.0); 6.9222 (1.3); 6.7370 (2.4); 6.5519 (1.4); 5.6832 (0.7); 5.6660 (0.8); 5.6467 (0.7); 3.9787 (16.0); 1.5756 (13.9); 1.4867 (5.2); 1.4699 (5.2); 1.2648 (0.5); 0.8820 (0.9); 0.0079 (0.6); -0.0002 (19.3); -0.0085 (0.5) I.1-528: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6431 (1.8); 8.6371 (2.6); 8.6098 (2.1); 8.6038 (1.5); 8.0862 (1.7); 8.0661 (1.8); 8.0449 (1.9); 8.0398 (1.9); 7.7053 (1.6); 7.6845 (2.2); 7.6583 (1.0); 7.6542 (1.1); 7.6383 (0.9); 7.6342 (1.0); 7.5927 (1.2); 7.5875 (1.2); 7.5720 (0.9); 7.5665 (1.3); 7.5626 (1.3); 7.2613 (18.0); 6.9313 (1.0); 6.7461 (1.6); 6.5610 (1.0); 5.6184 (0.6); 5.6156 (0.5); 3.9734 (12.1); 2.0456 (0.5); 1.5643 (16.0); 1.4436 (3.8); 1.4268 (3.8); 1.2645 (0.7); 1.2599 (0.7); 0.8820 (1.1); 0.0080 (0.7); -0.0002 (22.0); -0.0085 (0.6) I.1-529: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6501 (2.4); 8.6441 (3.5); 8.6212 (3.0); 8.6152 (2.0); 8.0887 (2.3); 8.0687 (2.5); 7.6630 (6.0); 7.6583 (6.2); 7.6518 (1.5); 7.6477 (1.5); 7.6318 (1.3); 7.6277 (1.4); 7.5628 (1.8); 7.5004 (1.6); 7.4958 (2.9); 7.4911 (1.4); 7.2614 (16.4); 7.2017 (0.6); 7.1821 (0.6); 6.9293 (1.3); 6.7442 (2.3); 6.5590 (1.4); 5.6305 (0.7); 5.6135 (0.8); 5.6107 (0.8); 5.5938 (0.7); 3.9748 (16.0); 2.0458 (0.8); 1.5714 (2.0); 1.4447 (5.4); 1.4279 (5.3); 1.2646 (0.9); 1.2599 (1.0); 0.8820 (1.4); 0.8643 (0.6); 0.0079 (0.6); -0.0002 (19.8); -0.0085 (0.6) I.1-530: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6453 (2.4); 8.6393 (3.4); 8.6107 (2.8); 8.6047 (2.0); 8.0869 (2.2); 8.0668 (2.4); 7.8963 (2.4); 7.8912 (2.5); 7.6588 (1.4); 7.6547 (1.5); 7.6426 (1.3); 7.6382 (1.8); 7.6347 (1.5); 7.6218 (1.7); 7.6166 (1.6); 7.5643 (1.7); 7.5319 (2.9); 7.5111 (2.0); 7.2611 (32.8); 7.2081 BCS241005-Foreign STR 200 (0.6); 7.1873 (0.6); 6.9337 (1.3); 6.7485 (2.1); 6.5634 (1.4); 5.6411 (0.6); 5.6241 (0.7); 5.6214 (0.7); 5.6044 (0.6); 3.9738 (16.0); 2.0458 (1.4); 1.5642 (3.8); 1.4455 (5.2); 1.4287 (5.1); 1.2775 (0.9); 1.2645 (1.6); 1.2599 (1.9); 1.2420 (0.6); 0.8988 (0.8); 0.8820 (2.8); 0.8643 (1.1); 0.0080 (1.2); -0.0002 (39.8); - 0.0085 (1.1) I.1-532: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6891 (6.1); 8.6831 (8.5); 8.6557 (7.8); 8.6496 (5.7); 8.2198 (6.0); 8.1998 (6.6); 7.7603 (3.5); 7.7563 (3.7); 7.7402 (3.2); 7.7362 (3.6); 7.6991 (15.4); 7.6944 (16.0); 7.6648 (4.9); 7.5193 (0.8); 7.5140 (4.6); 7.5094 (8.2); 7.5047 (4.1); 7.4230 (1.7); 7.4039 (1.7); 7.2908 (0.8); 7.2609 (119.8); 6.9972 (0.6); 5.6656 (1.7); 5.6476 (2.2); 5.6295 (1.7); 5.6119 (0.5); 5.3003 (6.0); 1.4990 (12.8); 1.4823 (12.9); 0.0296 (0.8); 0.0079 (3.9); -0.0002 (139.1); -0.0085 (4.2); -0.1493 (0.6) I.1-533: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6254 (2.4); 8.6213 (2.9); 8.5824 (2.5); 8.5784 (2.1); 7.9447 (2.2); 7.9315 (2.3); 7.8601 (5.0); 7.8572 (5.6); 7.8014 (1.5); 7.7985 (2.5); 7.7957 (1.2); 7.2961 (1.8); 7.2937 (2.0); 7.2671 (0.5); 7.2603 (28.9); 7.2428 (0.5); 7.2399 (0.4); 7.2377 (0.5); 7.2260 (1.6); 7.2235 (1.4); 7.2128 (1.2); 7.2103 (1.2); 5.7047 (0.6); 5.6918 (0.7); 5.6803 (0.6); 4.2695 (0.5); 4.2578 (0.6); 4.2541 (0.9); 4.2424 (0.8); 4.2002 (0.8); 4.1886 (0.9); 4.1848 (0.6); 4.1732 (0.6); 3.9341 (14.0); 2.0044 (1.2); 1.5768 (0.4); 1.5635 (1.2); 1.5570 (50.0); 1.5343 (0.3); 1.5032 (3.1); 1.4916 (6.5); 1.4800 (3.1); 1.3855 (4.6); 1.3743 (4.6); 0.0054 (0.8); -0.0001 (26.3); -0.0055 (0.9) I.1-534: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6470 (2.6); 8.6410 (3.2); 8.5934 (2.8); 8.5874 (2.3); 8.2505 (3.7); 8.0203 (1.6); 7.9628 (2.4); 7.9431 (2.6); 7.4342 (0.6); 7.4151 (0.6); 7.3049 (2.2); 7.3015 (2.3); 7.2617 (16.2); 7.2460 (1.5); 7.2422 (1.4); 7.2263 (1.4); 7.2225 (1.3); 5.7695 (0.7); 5.7521 (0.8); 5.7331 (0.7); 4.2826 (0.5); 4.2651 (0.6); 4.2595 (1.1); 4.2420 (1.0); 4.2148 (1.0); 4.1974 (1.1); 4.1917 (0.6); 4.1743 (0.6); 3.9401 (16.0); 1.5802 (10.9); 1.5158 (3.4); 1.4984 (7.2); 1.4810 (3.4); 1.4294 (5.3); 1.4126 (5.3); 0.0079 (0.6); -0.0002 (19.6); -0.0085 (0.6) I.1-535: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6251 (2.3); 8.6190 (3.4); 8.5949 (2.9); 8.5888 (2.0); 7.7142 (1.4); 7.7102 (2.3); 7.7061 (1.4); 7.5587 (1.4); 7.3788 (1.2); 7.2611 (27.9); 7.2124 (0.6); 7.1920 (0.6); 7.1737 (2.2); 7.0567 (1.3); 7.0535 (1.2); 7.0336 (1.3); 7.0304 (1.2); 5.7413 (0.6); 5.7241 (0.7); 5.7215 (0.7); 5.7044 (0.6); 3.9786 (16.0); 3.9732 (14.2); 1.5602 (13.2); 1.4123 (4.9); 1.3955 (4.9); 0.0080 (1.0); - 0.0002 (33.8); -0.0085 (0.9) I.1-536: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6251 (2.6); 8.6190 (3.2); 8.5748 (2.8); 8.5688 (2.3); 7.9500 (2.4); 7.9302 (2.6); 7.9071 (2.5); 7.9019 (2.6); 7.6495 (1.2); 7.6443 (1.1); 7.6287 (1.7); 7.6235 (1.6); 7.5329 (3.0); 7.5121 (2.1); 7.2994 (2.2); 7.2959 (2.4); 7.2859 (0.7); 7.2617 (15.6); 7.2385 (1.5); 7.2347 (1.4); 7.2187 (1.4); 7.2149 (1.3); 5.7258 (0.7); 5.7087 (0.8); 5.6893 (0.7); 4.2774 (0.6); 4.2598 (0.6); 4.2542 (1.0); 4.2367 (1.0); 4.2040 (1.0); 4.1866 (1.1); 4.1809 (0.6); 4.1635 (0.6); 3.9347 (16.0); 1.5814 BCS241005-Foreign STR 201 (3.8); 1.5078 (3.5); 1.4904 (7.2); 1.4730 (3.4); 1.3907 (5.3); 1.3740 (5.3); 0.0079 (0.6); -0.0002 (18.4); - 0.0085 (0.5) I.1-537: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2541 (0.5); 9.2500 (0.6); 9.2418 (0.6); 9.2377 (0.6); 8.6984 (1.0); 8.6923 (1.5); 8.6695 (1.7); 8.6635 (1.2); 8.1654 (1.4); 8.1442 (1.6); 7.8837 (0.7); 7.8795 (0.7); 7.8349 (1.5); 7.8136 (1.4); 7.7989 (0.9); 7.7944 (2.3); 7.7896 (3.6); 7.7868 (1.0); 7.7778 (0.6); 7.7729 (1.1); 7.7682 (1.1); 7.7655 (0.7); 7.7636 (0.6); 5.6740 (2.8); 3.3220 (16.0); 2.5250 (0.5); 2.5204 (0.7); 2.5116 (9.0); 2.5070 (19.4); 2.5025 (26.7); 2.4979 (18.3); 2.4933 (8.0); 1.4729 (1.7); 1.4557 (1.7); - 0.0002 (15.6) I.1-538: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1297 (4.2); 9.1132 (4.4); 8.6857 (8.7); 8.6796 (13.5); 8.6611 (14.7); 8.6550 (9.7); 8.0729 (12.4); 8.0685 (4.4); 8.0564 (5.0); 8.0518 (14.8); 8.0196 (0.6); 7.9556 (6.3); 7.9516 (10.7); 7.9477 (7.1); 7.9228 (0.8); 7.9191 (1.1); 7.9148 (0.6); 7.8917 (6.4); 7.8871 (11.9); 7.8826 (6.5); 7.8462 (7.8); 7.8423 (9.5); 7.8379 (5.9); 7.7825 (13.9); 7.7780 (4.6); 7.7659 (4.6); 7.7614 (12.1); 5.3341 (0.6); 5.3171 (2.7); 5.3002 (4.2); 5.2833 (2.8); 5.2663 (0.6); 3.3444 (1.1); 2.5290 (1.3); 2.5243 (2.2); 2.5155 (25.4); 2.5111 (52.6); 2.5065 (71.1); 2.5020 (49.6); 2.4975 (22.4); 1.4686 (16.0); 1.4514 (15.9); 1.2298 (0.8); 0.0080 (1.3); -0.0002 (35.0); -0.0085 (1.1) I.1-543: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6890 (0.7); 8.6647 (0.8); 8.6586 (0.5); 8.1146 (0.6); 8.0933 (0.8); 7.9837 (2.8); 7.7995 (0.7); 7.7783 (0.6); 5.4363 (1.1); 3.3240 (16.0); 2.5118 (4.4); 2.5073 (9.5); 2.5027 (13.1); 2.4982 (8.9); 2.4936 (3.9); 1.4775 (0.8); 1.4602 (0.8); -0.0002 (11.2) I.1-544: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2541 (1.2); 9.2499 (1.2); 9.2418 (1.2); 9.2376 (1.2); 9.1654 (0.9); 9.1490 (0.9); 8.7018 (2.1); 8.6957 (3.1); 8.6727 (3.5); 8.6666 (2.5); 8.1624 (2.9); 8.1578 (0.9); 8.1459 (1.0); 8.1412 (3.4); 8.0051 (12.9); 7.9059 (1.0); 7.9018 (1.0); 7.8848 (1.5); 7.8806 (1.4); 7.8285 (3.2); 7.8238 (1.0); 7.8119 (1.0); 7.8072 (2.9); 7.7978 (1.8); 7.7855 (1.6); 7.7766 (1.2); 7.7643 (1.2); 5.6736 (6.0); 5.3018 (0.6); 5.2850 (0.9); 5.2681 (0.6); 3.3223 (16.0); 2.5256 (0.8); 2.5209 (1.1); 2.5122 (15.5); 2.5077 (33.4); 2.5031 (46.2); 2.4985 (31.7); 2.4940 (13.9); 1.9898 (2.2); 1.4824 (3.5); 1.4652 (3.5); 1.2308 (0.6); 1.1931 (0.7); 1.1753 (1.3); 1.1576 (0.6); 0.0079 (1.2); -0.0002 (39.7); -0.0085 (1.1) I.1-545: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6360 (1.6); 8.6301 (2.0); 8.5859 (2.1); 8.5799 (1.7); 7.9533 (2.4); 7.9336 (2.6); 7.7147 (1.5); 7.7106 (2.6); 7.7067 (1.6); 7.5660 (1.6); 7.3736 (1.6); 7.3283 (0.7); 7.3085 (0.8); 7.2981 (2.3); 7.2949 (2.5); 7.2625 (9.2); 7.2352 (1.4); 7.2316 (1.4); 7.2155 (1.3); 7.2119 (1.3); 5.7254 (0.7); 5.7065 (0.9); 5.6891 (0.7); 4.2783 (0.6); 4.2607 (0.6); 4.2551 (1.0); 4.2376 (1.0); 4.2075 (1.0); 4.1901 (1.1); 4.1844 (0.6); 4.1669 (0.6); 3.9362 (16.0); 1.5102 (3.4); 1.4929 (7.1); 1.4755 (3.4); 1.3982 (5.3); 1.3814 (5.3); -0.0002 (10.4) BCS241005-Ausland STR 202 I.1-546: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6297 (2.5); 8.6236 (3.3); 8.5854 (2.8); 8.5793 (2.2); 7.9515 (2.4); 7.9317 (2.5); 7.6719 (5.9); 7.6672 (6.3); 7.5002 (1.6); 7.4955 (3.0); 7.4907 (1.5); 7.2971 (2.0); 7.2936 (2.2); 7.2611 (31.1); 7.2518 (0.7); 7.2313 (1.6); 7.2274 (1.4); 7.2115 (1.4); 7.2077 (1.3); 5.7173 (0.6); 5.6978 (0.7); 5.6808 (0.6); 4.2785 (0.5); 4.2610 (0.6); 4.2554 (1.0); 4.2378 (1.0); 4.2061 (1.0); 4.1887 (1.0); 4.1831 (0.6); 4.1656 (0.6); 3.9355 (16.0); 1.5605 (6.8); 1.5106 (3.4); 1.4932 (7.2); 1.4758 (3.3); 1.3882 (5.1); 1.3714 (5.1); 0.0079 (0.9); -0.0002 (34.8); -0.0085 (1.0) I.1-547: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6352 (2.6); 8.6292 (3.2); 8.5861 (3.1); 8.5801 (2.5); 7.9531 (2.6); 7.9333 (2.7); 7.8612 (1.8); 7.8578 (3.0); 7.8543 (1.9); 7.6091 (2.0); 7.5249 (2.0); 7.3236 (0.9); 7.2990 (3.2); 7.2961 (3.2); 7.2639 (4.7); 7.2356 (1.6); 7.2322 (1.6); 7.2159 (1.5); 7.2124 (1.5); 5.7230 (0.8); 5.7049 (1.1); 5.6868 (0.8); 4.2778 (0.6); 4.2602 (0.7); 4.2547 (1.2); 4.2372 (1.2); 4.2074 (1.2); 4.1900 (1.2); 4.1844 (0.7); 4.1669 (0.6); 3.9360 (16.0); 1.5100 (3.7); 1.4926 (7.5); 1.4753 (3.6); 1.3983 (6.0); 1.3815 (6.0); -0.0002 (5.4) I.1-548: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6199 (2.2); 8.6138 (3.4); 8.5938 (2.8); 8.5878 (1.8); 7.6708 (5.7); 7.6661 (6.1); 7.5033 (1.6); 7.4986 (2.9); 7.4939 (1.4); 7.2613 (17.7); 7.1796 (2.4); 7.1558 (0.5); 7.0555 (1.3); 7.0523 (1.2); 7.0324 (1.3); 7.0292 (1.2); 5.7354 (0.6); 5.7184 (0.7); 5.7155 (0.7); 5.6984 (0.6); 3.9777 (16.0); 3.9738 (14.1); 1.5650 (9.6); 1.4031 (4.8); 1.3863 (4.8); 0.0080 (0.6); -0.0002 (20.1); -0.0085 (0.6) I.1-549: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6244 (2.4); 8.6184 (3.5); 8.5954 (2.9); 8.5894 (2.0); 7.8599 (1.4); 7.8560 (2.5); 7.8521 (1.5); 7.6011 (1.4); 7.5989 (1.3); 7.5306 (1.3); 7.2614 (19.0); 7.1999 (0.6); 7.1743 (2.4); 7.0569 (1.3); 7.0536 (1.3); 7.0338 (1.3); 7.0305 (1.2); 5.7390 (0.6); 5.7219 (0.7); 5.7191 (0.7); 5.7020 (0.6); 3.9784 (16.0); 3.9728 (14.2); 1.5691 (6.2); 1.4117 (4.9); 1.3948 (4.9); 0.0079 (0.6); - 0.0002 (21.6); -0.0085 (0.6) I.1-550: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6138 (2.4); 8.6078 (3.5); 8.5822 (2.8); 8.5762 (2.0); 8.0553 (2.5); 8.0502 (2.5); 7.7069 (2.1); 7.6862 (3.0); 7.5970 (1.6); 7.5918 (1.6); 7.5763 (1.2); 7.5711 (1.2); 7.2624 (10.7); 7.1810 (2.6); 7.1606 (0.6); 7.0624 (1.3); 7.0591 (1.2); 7.0392 (1.3); 7.0359 (1.2); 5.7365 (0.6); 5.7196 (0.7); 5.7166 (0.7); 5.6995 (0.6); 3.9763 (16.0); 3.9703 (14.0); 2.0079 (1.1); 1.5927 (4.1); 1.4038 (4.8); 1.3870 (4.8); -0.0002 (12.0) I.1-551: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6368 (1.8); 8.6307 (2.4); 8.6012 (2.0); 8.5951 (1.4); 8.2477 (2.3); 8.0239 (1.0); 7.2617 (11.4); 7.1853 (1.5); 7.0701 (0.9); 7.0669 (0.9); 7.0471 (0.9); 7.0438 (0.9); 5.7686 (0.5); 5.7660 (0.5); 3.9822 (16.0); 1.5780 (10.3); 1.4443 (3.4); 1.4274 (3.4); -0.0002 (12.7) BCS241005-Ausland STR 203 I.1-556: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6071 (0.8); 8.6020 (1.9); 8.5964 (1.8); 8.5906 (0.7); 8.2073 (1.6); 8.1870 (1.7); 7.7468 (1.7); 7.7265 (1.6); 7.7011 (0.6); 7.6728 (1.2); 7.6533 (1.0); 7.3841 (1.0); 7.3615 (1.0); 7.2622 (16.0); 4.0244 (0.9); 3.9804 (1.0); 3.9562 (6.2); 3.7770 (6.8); 3.7695 (6.9); 3.3901 (0.9); 3.3460 (0.8); 2.1745 (0.7); 1.6878 (0.5); 1.6731 (5.4); 1.6543 (0.6); 1.6472 (0.7); 1.5606 (16.0); 1.2632 (1.0); 0.8816 (1.1); 0.8636 (0.5); 0.6542 (1.2); 0.6358 (2.6); 0.6174 (1.2); -0.0002 (16.7) I.1-557: 1H-NMR(400.6 MHz, CDCl3): δ= 8.5444 (0.6); 8.5064 (0.6); 8.1916 (0.6); 8.1707 (0.7); 7.7269 (0.7); 7.7062 (0.6); 7.2618 (16.5); 3.9542 (2.6); 3.7739 (3.2); 3.7696 (3.1); 1.7483 (2.0); 1.5553 (16.0); 0.7287 (0.5); 0.7105 (1.1); -0.0002 (17.4); -0.0083 (0.8) I.1-558: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6452 (1.1); 8.6392 (1.3); 8.6063 (1.3); 8.6004 (0.9); 8.4498 (0.9); 8.4300 (0.9); 8.2938 (2.0); 8.2397 (1.4); 8.2190 (1.5); 7.7847 (1.5); 7.7639 (1.4); 7.4761 (0.9); 7.4540 (0.9); 7.2620 (20.6); 3.9731 (5.7); 3.7906 (12.0); 2.1747 (1.3); 1.7649 (0.5); 1.5627 (16.0); 1.2638 (0.9); 0.8819 (1.1); 0.8639 (0.5); 0.7656 (1.1); 0.7470 (2.3); 0.7285 (1.0); -0.0002 (21.6); -0.0084 (1.2) I.1-559: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6406 (1.0); 8.6347 (1.3); 8.6040 (1.2); 8.5980 (0.9); 8.3882 (0.8); 8.3688 (0.9); 8.2842 (2.0); 8.2377 (1.4); 8.2168 (1.5); 7.7837 (1.5); 7.7628 (1.3); 7.4654 (0.9); 7.4432 (0.9); 7.2607 (18.6); 6.3856 (1.7); 3.9716 (5.8); 3.5753 (2.8); 1.7640 (0.5); 1.5540 (16.0); 1.2646 (1.0); 0.8820 (1.2); 0.8643 (0.5); 0.7651 (1.1); 0.7466 (2.4); 0.7281 (1.0); -0.0002 (17.6); -0.0083 (0.9) I.2-1:1H-NMR (400.6 MHz, d6-DMSO): δ= 8.6960 (0.6); 8.6899 (0.9); 8.6698 (1.1); 8.6637 (0.7); 8.1709 (0.5); 7.9183 (0.6); 7.6570 (0.5); 7.6563 (0.5); 3.8362 (4.2); 3.3236 (16.0); 2.5201 (0.6); 2.5114 (7.1); 2.5069 (15.2); 2.5023 (21.0); 2.4977 (14.4); 2.4931 (6.3); 1.4896 (1.0); 1.4724 (1.0); -0.0002 5 (14.8). I.2-3:1H-NMR (400.6 MHz, CDCl3): δ= 8.6683 (2.4); 8.6622 (2.9); 8.6095 (2.4); 8.6034 (2.0); 8.3098 (1.0); 8.3058 (1.8); 8.3020 (1.1); 8.2464 (3.0); 8.2172 (0.7); 8.2139 (1.0); 8.2101 (0.7); 8.1977 (0.8); 8.1940 (1.0); 8.1906 (0.7); 8.0157 (1.3); 7.8970 (0.6); 7.8927 (0.8); 7.8896 (0.7); 7.8779 (0.8); 7.8736 10 (1.0); 7.8704 (0.8); 7.6731 (1.0); 7.6539 (1.7); 7.6345 (0.8); 7.2605 (47.4); 5.6849 (0.6); 5.6662 (0.7); 5.6492 (0.6); 3.9529 (16.0); 1.5547 (1.6); 1.4898 (5.0); 1.4731 (5.0); 0.8821 (0.6); 0.0079 (1.7); -0.0002 (58.8); -0.0085 (1.9) I.2-4: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6351 (2.3); 8.6291 (3.0); 8.5895 (2.7); 8.5834 (2.1); 8.3044 15 (1.1); 8.3003 (2.1); 8.2962 (1.2); 8.2017 (0.7); 8.1985 (1.1); 8.1948 (0.8); 8.1822 (0.8); 8.1789 (1.2); 8.1752 (0.8); 7.9179 (0.7); 7.9146 (0.9); 7.9105 (0.7); 7.8988 (0.8); 7.8954 (1.0); 7.8914 (0.8); 7.6916 (0.5); 7.6878 (1.0); 7.6848 (0.9); 7.6766 (1.1); 7.6719 (3.2); 7.6679 (3.3); 7.6598 (1.2); 7.6404 (2.0); 7.6211 (0.9); 7.5541 (0.6); 7.5513 (0.7); 7.5493 (0.6); 7.5465 (0.6); 7.5346 (0.9); 7.5308 (1.3); 7.5269 BCS241005-Foreign STR 204 (0.8); 7.4561 (1.4); 7.4360 (1.6); 7.4158 (0.8); 7.3557 (0.6); 7.3366 (0.6); 7.2617 (12.8); 5.6605 (0.7); 5.6434 (0.8); 5.6241 (0.7); 5.2997 (9.6); 3.9444 (16.0); 3.9282 (0.8); 1.7801 (1.1); 1.7674 (2.7); 1.7610 (2.8); 1.7488 (1.3); 1.5906 (1.1); 1.4817 (0.8); 1.4789 (0.8); 1.4680 (2.9); 1.4609 (7.5); 1.4440 (5.4); 0.0079 (0.6); -0.0002 (16.2); -0.0085 (0.5) 5 I.2-5: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.0766 (0.5); 9.4251 (0.9); 9.4087 (1.0); 8.6947 (2.0); 8.6886 (3.6); 8.6742 (4.0); 8.6680 (2.4); 8.4308 (3.2); 8.2785 (1.4); 8.1844 (1.1); 8.1806 (2.0); 8.1766 (1.2); 8.0305 (0.7); 8.0274 (1.1); 8.0235 (0.7); 8.0111 (0.8); 8.0079 (1.1); 8.0041 (0.8); 7.9509 (0.7); 7.9478 (0.9); 7.9435 (0.6); 7.9318 (0.8); 7.9275 (1.0); 7.9243 (0.7); 7.6541 (1.0); 7.6349 (1.9); 7.6156 (0.9); 5.3771 (0.6); 5.3603 (0.9); 5.3432 (0.6); 3.3222 (16.0); 2.5254 (0.8); 2.5207 (1.2); 2.5120 (20.4); 2.5074 (44.2); 2.5029 (61.5); 2.4983 (42.3); 2.4937 (18.5); 1.9895 (1.0); 1.5273 (3.6); 1.5101 (3.6); 1.1753 (0.6); 0.0080 (0.8); -0.0002 (27.7); -0.0086 (0.8) I.2-7: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.0972 (0.5); 9.1827 (1.4); 9.1664 (1.4); 8.6833 (3.0); 15 8.6771 (5.4); 8.6631 (6.0); 8.6570 (3.6); 8.1851 (1.6); 8.1810 (3.0); 8.1772 (1.7); 8.0434 (1.1); 8.0403 (1.6); 8.0363 (1.1); 8.0240 (1.2); 8.0203 (1.6); 8.0169 (1.2); 7.9443 (3.2); 7.9401 (4.4); 7.9363 (3.0); 7.9252 (1.2); 7.9209 (1.5); 7.9178 (1.1); 7.7415 (1.9); 7.7388 (1.5); 7.7366 (1.2); 7.7138 (2.0); 7.7110 (2.1); 7.7084 (1.6); 7.6579 (1.5); 7.6386 (2.7); 7.6191 (1.3); 5.3196 (0.9); 5.3028 (1.4); 5.2859 (0.9); 4.0386 (0.5); 4.0208 (0.5); 3.3223 (16.0); 2.5253 (1.4); 2.5205 (1.8); 2.5118 (27.4); 2.5072 (59.6); 20 2.5026 (83.0); 2.4980 (56.9); 2.4935 (24.8); 1.9894 (2.4); 1.4882 (5.4); 1.4710 (5.4); 1.3560 (0.7); 1.1929 (0.7); 1.1751 (1.4); 1.1573 (0.7); 0.0080 (1.1); -0.0002 (38.5); -0.0085 (1.0) I.2-8: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6664 (2.4); 8.6603 (2.9); 8.6050 (2.6); 8.5989 (2.2); 8.3045 (1.0); 8.3003 (2.0); 8.2965 (1.1); 8.2116 (0.7); 8.2082 (1.0); 8.2046 (0.7); 8.1921 (0.8); 8.1884 (1.1); 25 8.1851 (0.8); 7.9685 (1.7); 7.9645 (1.2); 7.9416 (1.6); 7.9402 (1.6); 7.8988 (0.7); 7.8946 (0.8); 7.8913 (0.7); 7.8796 (0.8); 7.8753 (1.0); 7.8722 (0.8); 7.7407 (1.5); 7.6670 (1.0); 7.6477 (1.8); 7.6283 (0.8); 7.4606 (0.5); 7.4418 (0.6); 7.2617 (9.9); 5.6589 (0.7); 5.6417 (0.8); 5.6228 (0.6); 3.9500 (16.0); 1.4749 (5.2); 1.4582 (5.2); 1.2635 (0.8); 1.2600 (0.8); 0.8818 (1.2); -0.0002 (12.0) 30 I.2-9:1H-NMR (400.6 MHz, CDCl3): δ= 8.6456 (4.2); 8.5974 (4.2); 8.2869 (4.1); 8.2020 (2.2); 8.1826 (2.4); 7.8772 (2.1); 7.8588 (2.5); 7.6655 (9.4); 7.6398 (2.8); 7.6216 (1.4); 7.4922 (3.9); 7.3206 (1.6); 7.2996 (1.6); 7.2608 (23.5); 5.6281 (1.2); 5.6113 (1.9); 5.5938 (1.3); 3.9481 (16.0); 1.5606 (14.8); 1.4461 (7.6); 1.4293 (7.8); 1.2620 (0.6); -0.0002 (28.5) 35 I.2-10: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6634 (2.0); 8.6573 (2.5); 8.6063 (2.1); 8.6002 (1.7); 8.3326 (0.8); 8.3283 (1.5); 8.3250 (0.9); 8.3239 (0.9); 8.2458 (2.6); 8.2446 (2.6); 8.2434 (2.6); 8.2402 (1.3); 8.2359 (0.7); 8.2234 (0.6); 8.2194 (0.9); 8.2163 (0.6); 8.0139 (1.1); 7.9040 (0.5); 7.9010 (0.7); 7.8996 BCS241005-Foreign STR 205 (0.7); 7.8965 (0.6); 7.8849 (0.6); 7.8818 (0.7); 7.8804 (0.8); 7.8773 (0.6); 7.6713 (0.8); 7.6519 (1.5); 7.6335 (0.6); 7.6325 (0.7); 7.2630 (6.3); 5.6844 (0.5); 5.6655 (0.6); 5.6484 (0.5); 5.2998 (3.7); 4.5262 (1.3); 4.5186 (1.2); 4.5146 (1.4); 4.5111 (1.2); 4.5029 (1.5); 3.7576 (1.7); 3.7518 (0.6); 3.7456 (1.8); 3.7400 (0.6); 3.7338 (1.5); 3.4196 (16.0); 1.6293 (3.0); 1.4919 (4.0); 1.4752 (4.0); 1.2638 (0.9); 1.2595 5 (0.9); 0.8817 (1.6); 0.8639 (0.6); -0.0002 (7.6) I.2-11: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6703 (2.4); 8.6642 (2.9); 8.6091 (2.6); 8.6030 (2.1); 8.3110 (1.0); 8.3068 (1.9); 8.3029 (1.1); 8.2484 (3.2); 8.2172 (0.7); 8.2138 (1.0); 8.2102 (0.7); 8.1977 (0.8); 8.1940 (1.1); 8.1907 (0.7); 8.0143 (1.4); 7.8997 (0.6); 7.8955 (0.8); 7.8922 (0.7); 7.8805 (0.8); 7.8763 10 (1.0); 7.8731 (0.8); 7.6734 (1.0); 7.6541 (1.8); 7.6347 (0.8); 7.5020 (0.5); 7.4830 (0.5); 7.2612 (13.3); 5.6855 (0.6); 5.6667 (0.8); 5.6494 (0.6); 3.9527 (16.0); 1.4919 (5.2); 1.4752 (5.2); 0.0079 (0.5); -0.0002 (16.8); -0.0085 (0.5) I.2-12: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7137 (2.1); 8.6244 (2.0); 8.3798 (2.8); 8.2705 (1.7); 8.2531 15 (3.9); 7.9941 (3.2); 7.9627 (4.6); 7.8526 (1.8); 7.7374 (3.4); 7.7182 (1.4); 7.6989 (2.3); 7.6793 (1.1); 7.5835 (0.9); 7.5652 (0.9); 7.5186 (1.0); 7.2602 (172.6); 6.9967 (0.9); 5.6885 (0.8); 5.6712 (1.1); 5.6538 (0.8); 1.5210 (5.2); 1.5045 (5.0); 1.4792 (1.0); 1.4420 (1.9); 1.4270 (1.2); 1.4194 (0.6); 1.4091 (1.1); 1.3877 (0.6); 1.3331 (3.4); 1.2841 (5.4); 1.2546 (16.0); 1.2366 (2.2); 0.8941 (1.2); 0.8797 (2.4); 0.8617 (1.4); 0.1457 (0.7); 0.0289 (0.5); 0.0080 (6.5); -0.0002 (214.8); -0.0085 (6.1); -0.1494 (0.8) 20 I.2-15: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7058 (7.2); 8.6999 (8.5); 8.6269 (8.1); 8.6210 (7.2); 8.5535 (1.4); 8.3924 (7.0); 8.2753 (16.0); 8.2539 (4.0); 8.1187 (0.7); 7.9986 (6.2); 7.9882 (3.8); 7.9687 (3.7); 7.7488 (2.6); 7.7292 (3.0); 7.7217 (3.9); 7.7024 (6.0); 7.6834 (2.7); 7.2610 (75.4); 5.7328 (0.6); 5.7153 (2.2); 5.6973 (3.1); 5.6797 (2.3); 5.6632 (0.6); 5.3002 (2.5); 2.1302 (3.7); 1.5324 (14.5); 1.5156 (15.1); 25 1.3328 (0.7); 1.2843 (1.0); 1.2551 (4.0); 0.8805 (0.6); 0.0080 (1.2); -0.0002 (82.0); -0.0082 (5.0) I.2-16: 1H-NMR (400.6 MHz, CDCl3): δ= 7.6791 (1.0); 7.6745 (0.8); 7.2600 (6.3); 1.4755 (0.9); 1.4588 (0.9); 1.3329 (0.8); 1.2839 (2.0); 1.2556 (16.0); 1.1610 (0.6); 1.1429 (0.6); 1.1209 (0.5); 1.0758 (0.6); 0.8965 (1.3); 0.8801 (2.9); 0.8744 (2.1); 0.8698 (1.8); 0.8624 (1.9); 0.8529 (2.9); 0.8362 (2.2); -0.0002 30 (7.4) I.2-17:1H-NMR (400.6 MHz, d6-DMSO): δ= 9.1837 (3.0); 9.1673 (3.1); 8.6839 (5.7); 8.6778 (10.2); 8.6637 (10.6); 8.6576 (6.1); 8.1864 (3.5); 8.1823 (6.4); 8.1782 (3.6); 8.0441 (2.1); 8.0410 (3.2); 8.0374 (2.1); 8.0248 (2.4); 8.0215 (3.5); 8.0180 (2.2); 7.9447 (6.1); 7.9408 (9.1); 7.9369 (5.2); 7.9264 (2.5); 35 7.9227 (3.2); 7.9193 (2.1); 7.7418 (4.2); 7.7141 (4.3); 7.7115 (4.4); 7.6590 (3.3); 7.6396 (5.9); 7.6204 (2.7); 5.3203 (1.9); 5.3034 (3.0); 5.2864 (2.0); 3.5739 (0.7); 3.5687 (0.7); 3.5087 (0.8); 3.3714 (0.7); 3.3406 (0.5); 3.1702 (16.0); 2.6767 (0.6); 2.6722 (0.8); 2.6676 (0.6); 2.5427 (0.6); 2.5258 (2.2); 2.5211 BCS241005-Foreign STR 206 (3.1); 2.5124 (47.5); 2.5079 (101.6); 2.5034 (139.6); 2.4989 (96.7); 2.4944 (42.8); 2.4717 (0.5); 2.3350 (0.6); 2.3305 (0.8); 2.3258 (0.6); 1.4888 (11.6); 1.4717 (11.6); 1.2588 (0.8); 1.2335 (6.0); 0.8530 (0.8); 0.0079 (1.6); -0.0002 (54.9); -0.0085 (1.6) 5 I.2-18:1H-NMR (400.6 MHz, d6-DMSO): δ= 8.6838 (0.8); 8.6777 (1.5); 8.6632 (1.5); 8.6571 (0.9); 8.1855 (0.5); 8.1813 (0.9); 8.1772 (0.5); 8.0205 (0.5); 7.9458 (0.9); 7.9420 (1.4); 7.9380 (0.9); 7.7416 (0.6); 7.7146 (0.6); 7.7121 (0.6); 7.6392 (0.8); 3.1691 (16.0); 2.5127 (8.8); 2.5082 (19.0); 2.5037 (26.2); 2.4992 (18.3); 2.4947 (8.2); 1.4885 (1.7); 1.4714 (1.7); 1.2338 (0.8); -0.0002 (10.6) 10 I.2-19: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6766 (2.0); 8.6705 (2.6); 8.6300 (2.3); 8.6239 (1.8); 8.3603 (0.9); 8.3561 (1.6); 8.3517 (0.9); 8.2467 (2.7); 8.2399 (0.8); 8.2364 (0.9); 8.2325 (0.6); 8.2200 (0.7); 8.2166 (0.9); 8.2129 (0.6); 8.0217 (1.1); 7.9983 (0.6); 7.9951 (0.7); 7.9909 (0.5); 7.9791 (0.7); 7.9758 (0.8); 7.9717 (0.6); 7.7280 (0.9); 7.7085 (1.6); 7.6892 (0.7); 7.2611 (20.0); 5.6825 (0.5); 5.6655 (0.6); 5.6464 (0.5); 5.0096 (4.4); 5.0025 (4.4); 1.5596 (16.0); 1.4949 (4.3); 1.4781 (4.3); 0.0080 (0.7); -0.0002 15 (23.8); -0.0084 (0.6) I.2-20: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6477 (2.3); 8.6417 (3.0); 8.6016 (2.7); 8.5955 (2.1); 8.2908 (1.1); 8.2867 (2.0); 8.2828 (1.1); 8.2046 (0.7); 8.2014 (1.1); 8.1975 (0.7); 8.1850 (0.8); 8.1816 (1.2); 7.9961 (1.4); 7.9924 (2.8); 7.9888 (1.5); 7.8795 (0.9); 7.8755 (0.6); 7.8639 (0.9); 7.8599 (1.0); 7.8565 20 (0.8); 7.8374 (1.5); 7.8331 (2.4); 7.8290 (1.4); 7.7356 (1.6); 7.7313 (2.3); 7.7271 (1.3); 7.6580 (1.1); 7.6388 (1.9); 7.6192 (0.9); 7.2602 (66.4); 5.6215 (0.7); 5.6044 (0.8); 5.5853 (0.6); 3.9475 (16.0); 1.5476 (5.1); 1.4451 (5.4); 1.4284 (5.3); 0.0079 (3.1); -0.0002 (94.7); -0.0085 (2.7) I.2-21:1H-NMR (400.6 MHz, CDCl3): δ= 8.6606 (5.6); 8.6547 (6.5); 8.6206 (3.0); 8.6084 (9.6); 8.6027 25 (6.3); 8.3874 (5.8); 8.2912 (3.1); 8.2716 (3.3); 8.2382 (11.1); 8.0145 (4.8); 7.9207 (2.7); 7.9016 (3.2); 7.7455 (1.4); 7.7413 (1.3); 7.7263 (3.2); 7.7222 (2.9); 7.7070 (2.0); 7.7029 (1.9); 7.6942 (2.9); 7.6749 (4.9); 7.6555 (2.3); 7.5064 (3.8); 7.4868 (3.2); 7.4581 (2.0); 7.4388 (2.0); 7.3836 (0.6); 7.3623 (0.8); 7.2618 (26.0); 7.2525 (2.7); 7.2333 (1.9); 5.6899 (1.9); 5.6724 (2.6); 5.6542 (1.9); 5.5309 (16.0); 4.8436 (2.3); 2.0456 (1.9); 1.4859 (12.8); 1.4693 (12.8); 1.2847 (0.7); 1.2770 (0.9); 1.2594 (2.1); 1.2420 (0.7); 30 0.8819 (0.8); -0.0002 (35.1) I.2-22: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6434 (2.1); 8.6379 (2.5); 8.5898 (2.4); 8.5840 (2.1); 8.2892 (2.4); 8.2749 (2.5); 8.1996 (1.3); 8.1800 (1.4); 7.8888 (1.1); 7.8719 (1.4); 7.7177 (1.1); 7.6972 (1.4); 7.6569 (1.2); 7.6373 (1.9); 7.6181 (0.9); 7.5122 (2.2); 7.4915 (1.8); 7.2836 (1.3); 7.2605 (41.3); 7.2580 35 (37.5); 5.6305 (0.8); 5.6134 (1.2); 5.5959 (0.8); 3.9456 (12.1); 3.9434 (11.0); 1.5526 (16.0); 1.4475 (5.2); 1.4308 (5.2); -0.0002 (52.2); -0.0027 (47.4); -0.0302 (0.7) BCS241005-Abroad STR 207 I.2-23: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6401 (3.0); 8.6361 (3.5); 8.5862 (3.2); 8.5822 (2.8); 8.2917 (1.4); 8.2889 (2.6); 8.2861 (1.5); 8.1967 (0.9); 8.1945 (1.4); 8.1922 (0.9); 8.1837 (1.0); 8.1814 (1.4); 8.1792 (0.9); 8.0627 (3.0); 8.0593 (3.0); 7.8843 (0.8); 7.8819 (1.1); 7.8794 (0.9); 7.8715 (1.0); 7.8690 (1.3); 7.8667 (0.9); 7.6849 (1.4); 7.6814 (1.4); 7.6711 (1.7); 7.6676 (1.7); 7.6493 (1.3); 7.6364 (2.4); 7.6235 (1.2); 7.5225 (3.2); 7.5087 (2.7); 7.3061 (0.7); 7.2929 (0.7); 7.2596 (40.5); 7.2536 (0.4); 5.6303 (0.8); 5.6188 (1.0); 5.6063 (0.8); 5.2981 (1.5); 3.9449 (18.9); 2.6130 (10.5); 1.5483 (44.5); 1.4435 (6.6); 1.4324 (6.6); 1.2542 (0.8); 0.0691 (5.5); 0.0051 (1.6); -0.0001 (50.0); -0.0058 (1.8) I.2-24: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6476 (2.3); 8.6415 (3.0); 8.5990 (2.7); 8.5929 (2.1); 8.2913 10 (1.1); 8.2871 (2.0); 8.2829 (1.1); 8.2043 (0.7); 8.2009 (1.0); 8.1973 (0.7); 8.1847 (0.8); 8.1812 (1.2); 8.1778 (0.8); 7.8989 (1.3); 7.8954 (2.4); 7.8919 (1.4); 7.8837 (0.7); 7.8803 (0.9); 7.8761 (0.7); 7.8644 (0.8); 7.8611 (1.0); 7.8571 (0.8); 7.6579 (1.1); 7.6386 (1.9); 7.6194 (0.9); 7.5853 (0.6); 7.5793 (0.8); 7.5757 (0.7); 7.5663 (0.6); 7.5605 (0.8); 7.5567 (0.7); 7.4948 (0.7); 7.4911 (0.8); 7.4852 (0.6); 7.4726 (0.7); 7.4690 (0.8); 7.4632 (0.6); 7.2946 (0.6); 7.2745 (0.6); 7.2603 (47.9); 7.2309 (0.5); 5.6265 (0.7);15 5.6090 (0.8); 5.5902 (0.6); 3.9472 (16.0); 1.5443 (15.8); 1.4448 (5.4); 1.4281 (5.4); 0.0079 (1.7); - 0.0002 (67.9); -0.0085 (2.2); -0.0295 (0.7) I.2-25: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6441 (0.8); 8.6400 (0.8); 8.5812 (0.7); 8.5772 (0.6); 8.2938 (0.3); 8.2911 (0.6); 8.2886 (0.3); 8.1969 (0.3); 8.1835 (0.3); 7.8035 (0.4); 7.8010 (0.3); 7.6710 (0.3); 20 7.6676 (0.3); 7.6571 (0.4); 7.6536 (0.7); 7.6400 (0.6); 7.5577 (0.8); 7.5438 (0.6); 7.2630 (8.2); 3.9453 (5.0); 3.4872 (16.2); 2.0124 (0.6); 2.0047 (50.0); 1.9959 (0.4); 1.5865 (1.0); 1.4501 (1.6); 1.4389 (1.6); 0.9856 (0.5); 0.0053 (0.3); -0.0001 (9.4) I.2-26: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6437 (1.0); 8.6396 (1.1); 8.5810 (1.0); 8.5770 (0.9); 8.2941 25 (0.4); 8.2914 (0.8); 8.2888 (0.5); 8.1962 (0.4); 8.1940 (0.3); 8.1855 (0.3); 8.1831 (0.5); 8.1809 (0.3); 7.8866 (0.4); 7.8762 (0.3); 7.8736 (0.4); 7.8714 (0.3); 7.8044 (0.6); 7.6723 (0.4); 7.6690 (0.4); 7.6584 (0.6); 7.6550 (0.6); 7.6534 (0.5); 7.6400 (0.8); 7.6271 (0.4); 7.5575 (1.0); 7.5436 (0.8); 7.2650 (5.2); 5.6266 (0.4); 5.2998 (1.7); 4.1392 (0.4); 4.1273 (1.2); 4.1154 (1.2); 4.1035 (0.4); 3.9451 (6.0); 3.4849 (15.5); 2.1160 (0.3); 2.0431 (5.5); 2.0268 (0.5); 2.0123 (0.4); 2.0046 (50.0); 1.9960 (0.6); 1.8897 (0.3); 30 1.6139 (0.4); 1.4506 (2.1); 1.4394 (2.1); 1.3023 (0.4); 1.2902 (0.5); 1.2805 (0.5); 1.2771 (0.4); 1.2705 (2.0); 1.2656 (1.1); 1.2586 (3.4); 1.2468 (1.7); 0.8936 (1.2); 0.8821 (2.9); 0.8702 (1.4); -0.0001 (6.0) I.2-27: 1H-NMR (600 MHz, CDCl3): δ= 8.6497 (6.4); 8.6457 (7.4); 8.5979 (7.6); 8.5939 (6.7); 8.2922 (3.9); 8.2895 (7.1); 8.2868 (4.2); 8.2010 (2.4); 8.1989 (3.8); 8.1968 (2.5); 8.1880 (2.6); 8.1859 (4.0); 35 8.1838 (2.6); 7.8772 (2.3); 7.8750 (3.2); 7.8726 (2.4); 7.8645 (2.6); 7.8621 (3.6); 7.8599 (2.7); 7.8506 (4.7); 7.8481 (8.3); 7.8457 (5.0); 7.6529 (3.6); 7.6400 (6.6); 7.6271 (3.1); 7.6039 (5.1); 7.5210 (5.0); 7.3336 (2.0); 7.3207 (2.1); 7.2600 (43.9); 7.2429 (0.4); 5.6418 (0.6); 5.6305 (2.3); 5.6185 (3.0); 5.6066 BCS241005-Foreign STR 208 (2.4); 5.5953 (0.7); 5.2981 (3.1); 3.9475 (47.6); 3.9304 (0.5); 2.6138 (1.4); 1.5590 (30.0); 1.4498 (17.3); 1.4386 (17.5); 1.2541 (2.2); 0.0051 (1.8); -0.0001 (50.0); -0.0055 (2.1); -0.0172 (0.5) I.2-28: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6497 (7.8); 8.6458 (8.8); 8.5978 (9.0); 8.5939 (7.8); 8.2900 5 (8.6); 8.1990 (4.6); 8.1860 (4.8); 7.8756 (4.2); 7.8628 (4.8); 7.8485 (9.4); 7.6529 (4.3); 7.6400 (7.7); 7.6272 (3.7); 7.6042 (6.8); 7.5211 (6.6); 7.3373 (2.8); 7.3245 (2.8); 7.2605 (29.3); 5.6422 (0.8); 5.6309 (2.9); 5.6190 (4.0); 5.6071 (2.9); 5.5958 (0.8); 5.2980 (1.8); 3.9683 (0.4); 3.9474 (50.0); 2.6147 (1.2); 1.5730 (11.7); 1.4500 (20.0); 1.4388 (20.1); 1.3338 (0.4); 1.2848 (0.5); 1.2557 (1.4); -0.0001 (33.8) 10 I.2-29: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6497 (7.8); 8.6458 (8.8); 8.5978 (9.0); 8.5939 (7.8); 8.2900 (8.6); 8.1990 (4.6); 8.1860 (4.8); 7.8756 (4.2); 7.8628 (4.8); 7.8485 (9.4); 7.6529 (4.3); 7.6400 (7.7); 7.6272 (3.7); 7.6042 (6.8); 7.5211 (6.6); 7.3373 (2.8); 7.3245 (2.8); 7.2621 (7.1); 3.9473 (1.2); 3.4925 (4.9); 3.4839 (5.1); 2.0121 (0.7); 2.0046 (50.0); 1.9959 (0.4); 1.5640 (2.9); 1.4480 (0.4); 1.4369 (0.4); 0.9592 (0.3); 0.9503 (0.9); 0.9416 (0.9); 0.0055 (0.3); -0.0001 (9.4); -0.0053 (0.3) 15 I.2-30: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6497 (6.4); 8.6457 (7.4); 8.5979 (7.6); 8.5939 (6.7); 8.2922 (3.9); 8.2895 (7.1); 8.2868 (4.2); 8.2010 (2.4); 8.1989 (3.8); 8.1968 (2.5); 8.1880 (2.6); 8.1859 (4.0); 8.1838 (2.6); 7.8772 (2.3); 7.8750 (3.2); 7.8726 (2.4); 7.8645 (2.6); 7.8621 (3.6); 7.8599 (2.7); 7.8506 (4.7); 7.8481 (8.3); 7.8457 (5.0); 7.6529 (3.6); 7.6400 (6.6); 7.6271 (3.1); 7.6039 (5.1); 7.5210 (5.0); 7.3336 (2.0); 7.3207 (2.1); 7.2594 (35.9); 3.9475 (1.0); 3.4953 (9.6); 3.4860 (9.7); 2.0432 (0.6); 2.0042 (50.0); 1.9956 (0.4); 1.9807 (0.4); 1.5343 (29.7); 1.4470 (0.4); 1.4359 (0.4); 1.2656 (0.6); 1.2588 (0.6); 1.2469 (0.3); 0.9130 (0.8); 0.9037 (2.5); 0.8944 (3.1); 0.8851 (1.1); 0.8823 (1.6); 0.8704 (0.8); 0.0053 (1.7); -0.0001 (48.8); -0.0053 (1.7); -0.0236 (0.4) 25 I.2-31: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6415 (7.4); 8.6375 (8.7); 8.5928 (8.6); 8.5888 (7.5); 8.3038 (4.1); 8.3011 (7.6); 8.2984 (4.6); 8.1951 (4.0); 8.1820 (4.2); 7.9181 (3.4); 7.9053 (3.8); 7.9028 (3.1); 7.7462 (0.8); 7.6528 (3.8); 7.6399 (7.0); 7.6271 (3.4); 7.5908 (7.6); 7.4390 (5.2); 7.3275 (1.8); 7.3148 (1.8); 7.2994 (1.0); 7.2599 (37.5); 7.2010 (5.1); 5.6646 (0.7); 5.6533 (2.5); 5.6413 (3.2); 5.6293 (2.5); 5.6180 (0.7); 5.2975 (0.5); 3.9428 (49.8); 3.9229 (0.4); 3.4898 (0.6); 3.0144 (0.5); 3.0031 (1.4); 2.9918 (2.8); 2.9803 (3.4); 2.9688 (2.5); 2.9573 (1.0); 2.6262 (0.3); 2.0034 (1.1); 1.6611 (0.3); 1.5719 (0.4); 1.5609 (0.4); 1.4662 (18.1); 1.4550 (18.2); 1.2987 (7.1); 1.2871 (7.4); 1.2790 (41.6); 1.2675 (41.5); 1.2478 (0.5); 0.9501 (0.5); 0.0052 (1.7); -0.0001 (50.0); -0.0054 (2.0); -0.0201 (0.3) I.2-32: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6375 (3.1); 8.6336 (3.6); 8.5922 (3.4); 8.5883 (2.9); 8.2999 35 (3.4); 8.1943 (1.7); 8.1812 (1.8); 7.9154 (1.7); 7.9027 (1.9); 7.6526 (1.6); 7.6397 (2.8); 7.6268 (1.4); 7.5898 (3.7); 7.4388 (2.7); 7.3144 (0.8); 7.3025 (0.9); 7.2634 (10.0); 7.2026 (2.6); 5.6505 (1.0); 5.6386 (1.4); 5.6267 (1.0); 3.9426 (17.3); 3.4840 (9.4); 3.0054 (0.4); 2.9939 (1.0); 2.9824 (1.4); 2.9709 (1.0); BCS241005-Abroad STR 209 2.9594 (0.4); 2.0032 (50.0); 1.9876 (0.4); 1.9829 (0.5); 1.4634 (8.1); 1.4522 (8.2); 1.2952 (0.7); 1.2806 (15.6); 1.2691 (15.4); -0.0001 (10.4) I.2-33: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6428 (5.2); 8.6387 (6.1); 8.5922 (5.8); 8.5881 (5.0); 8.3005 5 (2.8); 8.2978 (5.0); 8.2950 (2.9); 8.1996 (1.8); 8.1975 (2.7); 8.1953 (1.8); 8.1865 (1.8); 8.1844 (2.7); 8.1823 (1.7); 8.0695 (9.6); 7.8994 (1.7); 7.8971 (2.4); 7.8948 (1.7); 7.8867 (1.9); 7.8843 (2.6); 7.8821 (1.8); 7.8608 (5.4); 7.6542 (2.7); 7.6414 (7.6); 7.6284 (2.2); 7.6090 (3.4); 7.3574 (1.6); 7.3445 (1.6); 7.2615 (19.5); 5.6639 (0.5); 5.6526 (1.7); 5.6407 (2.1); 5.6286 (1.6); 5.6173 (0.4); 4.0342 (0.5); 4.0147 (33.1); 3.9645 (0.5); 3.9450 (33.4); 3.4870 (13.2); 2.0230 (0.7); 2.0175 (0.4); 2.0034 (50.0); 1.9949 10 (0.3); 1.5850 (1.8); 1.4670 (12.2); 1.4558 (12.2); 0.0195 (0.3); 0.0053 (1.1); -0.0001 (25.6); -0.0054 (0.7) I.2-34: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6428 (8.4); 8.6388 (9.7); 8.5920 (9.2); 8.5880 (8.0); 8.2979 (8.2); 8.1976 (4.4); 8.1845 (4.6); 8.0692 (15.0); 7.8966 (4.0); 7.8838 (4.4); 7.8601 (9.0); 7.6539 (4.2); 15 7.6411 (12.9); 7.6281 (3.6); 7.6090 (6.1); 7.3540 (2.9); 7.3410 (2.9); 7.2608 (24.8); 5.6645 (0.8); 5.6532 (2.7); 5.6411 (3.6); 5.6293 (2.7); 5.6180 (0.7); 4.0652 (0.3); 4.0346 (0.4); 4.0146 (49.7); 3.9650 (0.3); 3.9450 (50.0); 3.4872 (0.8); 2.6119 (0.6); 2.0031 (19.8); 1.5831 (12.4); 1.4667 (19.2); 1.4555 (19.2); 1.2562 (0.7); 0.0051 (1.7); -0.0001 (33.1) 20 I.2-35: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6414 (2.4); 8.6353 (3.0); 8.5955 (2.7); 8.5894 (2.1); 8.3000 (1.0); 8.2958 (2.0); 8.2918 (1.1); 8.2021 (0.7); 8.1986 (1.1); 8.1951 (0.7); 8.1827 (0.8); 8.1790 (1.1); 8.1755 (0.7); 7.9127 (0.6); 7.9089 (0.8); 7.9053 (0.7); 7.8936 (0.8); 7.8894 (1.0); 7.8862 (0.8); 7.6586 (1.1); 7.6394 (1.9); 7.6200 (0.9); 7.5254 (1.7); 7.4497 (1.3); 7.3128 (0.5); 7.2931 (0.6); 7.2603 (57.4); 7.1671 (1.2); 5.6515 (0.6); 5.6341 (0.8); 5.6153 (0.6); 3.9437 (16.0); 2.4473 (1.7); 2.4311 (8.5); 1.547425 (2.1); 1.4583 (5.4); 1.4416 (5.3); 0.0080 (2.5); -0.0002 (79.4); -0.0085 (2.1) I.2-36:1H-NMR (400.6 MHz, CDCl3): δ= 8.6750 (2.4); 8.6690 (2.9); 8.6117 (2.6); 8.6056 (2.2); 8.2963 (1.1); 8.2922 (2.0); 8.2881 (1.2); 8.2144 (0.7); 8.2110 (1.1); 8.2074 (0.7); 8.1948 (0.8); 8.1914 (1.1); 8.1879 (0.7); 8.0061 (1.4); 8.0026 (2.6); 7.9992 (1.5); 7.9252 (1.3); 7.8679 (0.6); 7.8644 (0.9); 7.8605 30 (0.7); 7.8487 (0.8); 7.8448 (1.0); 7.8413 (0.8); 7.6670 (1.1); 7.6475 (2.1); 7.6407 (1.2); 7.6382 (1.4); 7.6357 (1.2); 7.6286 (1.0); 7.5039 (0.6); 7.4846 (0.6); 7.2628 (6.3); 5.6509 (0.7); 5.6334 (0.8); 5.6152 (0.7); 3.9535 (16.0); 1.4578 (5.3); 1.4412 (5.2); -0.0002 (8.5) I.2-37:1H-NMR (400.6 MHz, CDCl3): δ= 8.6565 (2.3); 8.6504 (2.9); 8.6030 (2.6); 8.5970 (2.1); 8.2924 35 (1.0); 8.2884 (1.9); 8.2844 (1.1); 8.2078 (0.7); 8.2045 (1.0); 8.2007 (0.7); 8.1882 (0.8); 8.1847 (1.1); 8.1812 (0.7); 7.9662 (2.6); 7.9612 (2.9); 7.8787 (0.6); 7.8756 (0.8); 7.8712 (0.7); 7.8596 (0.8); 7.8552 (1.1); 7.8507 (3.2); 7.8456 (2.7); 7.6613 (1.0); 7.6421 (1.8); 7.6228 (0.8); 7.3223 (0.5); 7.3029 (0.6); BCS241005-Abroad STR 210 7.2623 (15.3); 5.6212 (0.6); 5.6042 (0.8); 5.5852 (0.6); 3.9501 (16.0); 2.0478 (0.6); 1.5861 (2.0); 1.4468 (5.0); 1.4301 (5.0); 0.0079 (0.7); -0.0002 (21.5); -0.0085 (0.6) I.2-38: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6467 (2.4); 8.6406 (2.9); 8.5917 (2.5); 8.5856 (2.0); 8.2939 5 (1.0); 8.2900 (1.8); 8.2861 (1.0); 8.2042 (0.7); 8.2010 (1.0); 8.1971 (0.7); 8.1847 (0.8); 8.1811 (1.0); 8.1776 (0.7); 8.0558 (2.4); 8.0506 (2.4); 7.8914 (0.6); 7.8883 (0.8); 7.8839 (0.7); 7.8722 (0.8); 7.8679 (0.9); 7.8647 (0.7); 7.7047 (2.0); 7.6840 (2.8); 7.6594 (1.0); 7.6402 (1.7); 7.6209 (0.8); 7.5993 (1.6); 7.5941 (1.5); 7.5785 (1.1); 7.5733 (1.1); 7.3249 (0.5); 7.3054 (0.5); 7.2619 (36.1); 5.6343 (0.6); 5.6173 (0.7); 5.5981 (0.6); 3.9465 (16.0); 1.5625 (7.5); 1.4465 (4.9); 1.4299 (4.9); 0.0080 (1.4); -0.0002 (51.9); 10 -0.0085 (1.6) I.2-39: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6480 (2.3); 8.6419 (2.9); 8.5920 (2.6); 8.5859 (2.1); 8.2951 (1.0); 8.2909 (2.0); 8.2865 (1.1); 8.2045 (0.7); 8.2007 (1.0); 8.1975 (0.7); 8.1850 (0.8); 8.1811 (1.1); 8.1780 (0.8); 7.9062 (2.3); 7.9011 (2.4); 7.8918 (0.7); 7.8875 (0.9); 7.8843 (0.7); 7.8726 (0.8); 7.8683 15 (1.0); 7.8652 (0.8); 7.6591 (1.1); 7.6490 (1.2); 7.6438 (1.2); 7.6398 (2.0); 7.6282 (1.6); 7.6229 (1.8); 7.5306 (2.8); 7.5099 (2.0); 7.3441 (0.5); 7.3249 (0.5); 7.2626 (12.1); 5.6392 (0.6); 5.6202 (0.8); 5.6031 (0.6); 3.9465 (16.0); 2.0476 (0.6); 1.5983 (1.0); 1.4475 (5.1); 1.4308 (5.1); 1.2606 (0.5); -0.0002 (17.3); -0.0085 (0.5) 20 I.2-40: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6566 (2.3); 8.6506 (2.9); 8.6023 (2.5); 8.5963 (2.0); 8.2923 (1.0); 8.2884 (1.8); 8.2846 (1.0); 8.2077 (0.7); 8.2045 (1.0); 8.2006 (0.7); 8.1882 (0.8); 8.1849 (1.0); 8.1811 (0.7); 7.8776 (0.6); 7.8746 (0.8); 7.8733 (0.8); 7.8701 (0.6); 7.8585 (0.8); 7.8553 (0.9); 7.8541 (0.9); 7.8510 (0.7); 7.8092 (11.4); 7.6611 (1.0); 7.6421 (1.7); 7.6231 (0.8); 7.3208 (0.5); 7.2626 (12.0); 5.6234 (0.6); 5.6064 (0.7); 5.5874 (0.6); 3.9501 (16.0); 1.5911 (1.6); 1.4457 (4.9); 1.4290 (4.9); 0.0080 25 (0.5); -0.0002 (17.1) I.2-41: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6330 (2.7); 8.6271 (3.2); 8.5882 (3.3); 8.5823 (2.5); 8.1617 (2.8); 8.1562 (2.8); 8.0627 (2.9); 8.0578 (2.8); 7.8208 (1.4); 7.8154 (1.3); 7.8003 (1.7); 7.7949 (1.6); 7.6900 (1.5); 7.6850 (1.4); 7.6692 (2.0); 7.6639 (2.1); 7.6589 (3.2); 7.6382 (2.4); 7.5317 (3.0); 7.5110 30 (2.3); 7.2629 (13.0); 7.2339 (1.1); 7.2140 (1.1); 5.6364 (1.0); 5.6179 (1.3); 5.6000 (1.0); 4.1487 (0.6); 4.1311 (1.8); 4.1132 (1.8); 4.0952 (0.7); 4.0647 (0.6); 3.9518 (16.0); 2.0476 (9.3); 1.5817 (8.2); 1.4498 (6.6); 1.4331 (6.5); 1.2783 (2.1); 1.2605 (4.1); 1.2427 (2.1); 0.9357 (0.9); -0.0002 (16.0) I.2-42: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6428 (2.5); 8.6368 (3.2); 8.6004 (3.1); 8.5945 (2.4); 8.1621 35 (2.6); 8.1566 (2.6); 7.8512 (1.8); 7.8476 (2.9); 7.8439 (1.7); 7.8100 (1.3); 7.8044 (1.2); 7.7894 (1.7); 7.7838 (1.6); 7.6630 (2.8); 7.6423 (2.2); 7.6037 (2.0); 7.5295 (1.9); 7.2623 (14.6); 7.2362 (1.0); 5.6373 BCS241005-Abroad STR 211 (0.8); 5.6198 (1.1); 5.6010 (0.8); 3.9550 (16.0); 1.5733 (5.7); 1.4560 (5.9); 1.4393 (6.0); -0.0002 (17.7); -0.0084 (1.0) I.2-43: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6833 (2.2); 8.6750 (2.3); 8.6600 (2.6); 8.6542 (3.6); 8.6391 5 (3.6); 8.6333 (2.2); 7.9889 (0.8); 7.9753 (2.4); 7.9557 (2.0); 7.7216 (1.7); 7.6885 (3.2); 7.6842 (3.4); 7.6747 (2.3); 7.6334 (0.7); 7.6164 (0.7); 7.5813 (1.5); 7.5516 (1.8); 7.5328 (4.4); 7.5122 (2.8); 7.4979 (2.6); 7.3707 (3.7); 7.2635 (15.7); 7.1718 (1.1); 7.1533 (1.1); 5.2610 (0.5); 5.2440 (0.8); 5.2262 (0.6); 5.2038 (1.0); 5.1862 (1.4); 5.1683 (1.0); 4.1491 (1.1); 4.1312 (3.0); 4.1134 (3.1); 4.0955 (1.1); 4.0819 (0.6); 4.0650 (1.1); 4.0484 (0.6); 3.9677 (14.2); 3.9445 (7.6); 2.0476 (16.0); 1.5978 (9.4); 1.4658 (6.2); 10 1.4489 (6.2); 1.3912 (0.6); 1.3722 (0.8); 1.3571 (3.5); 1.3406 (3.3); 1.2783 (3.5); 1.2605 (6.8); 1.2426 (3.5); 0.9541 (0.9); 0.9357 (1.6); 0.9173 (0.8); -0.0002 (19.6) I.2-44: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6495 (2.4); 8.6437 (3.4); 8.6229 (3.4); 8.6170 (2.3); 8.1980 (3.0); 8.1713 (2.0); 8.1671 (2.7); 7.8862 (1.8); 7.8819 (2.8); 7.8776 (1.6); 7.6991 (2.8); 7.5573 (2.1); 15 7.3745 (2.0); 7.2623 (14.2); 7.2405 (1.1); 5.5884 (0.9); 5.5706 (1.2); 5.5527 (0.9); 3.9577 (16.0); 1.5745 (7.4); 1.4929 (6.3); 1.4762 (6.3); 1.2629 (0.8); 0.8819 (0.9); -0.0002 (16.7) I.2-45: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6714 (1.1); 8.1397 (1.1); 8.1347 (0.9); 8.1189 (1.1); 8.1138 (1.1); 8.0858 (0.8); 7.6441 (1.0); 7.6229 (0.9); 7.5287 (1.1); 7.5084 (0.9); 7.2620 (22.4); 3.9387 (1.8); 20 3.9193 (1.4); 2.0479 (2.1); 1.5588 (16.0); 1.4314 (0.7); 1.3497 (0.8); 1.3360 (0.8); 1.2606 (0.7); -0.0002 (27.4); -0.0084 (1.4) I.2-46: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6750 (1.8); 8.6649 (2.0); 8.6582 (1.4); 8.6507 (2.6); 8.6448 (3.5); 8.6278 (3.4); 8.6218 (2.1); 7.9833 (0.7); 7.9706 (2.4); 7.9586 (1.1); 7.9512 (2.1); 7.9188 (1.5); 25 7.9138 (1.4); 7.8833 (2.9); 7.8786 (2.6); 7.7028 (1.4); 7.6988 (1.4); 7.6839 (1.8); 7.6799 (1.6); 7.6600 (0.8); 7.6392 (1.0); 7.6201 (1.4); 7.6148 (1.3); 7.5989 (2.4); 7.5942 (2.1); 7.5787 (0.7); 7.5489 (1.8); 7.5290 (4.6); 7.5241 (4.1); 7.5034 (4.1); 7.4931 (2.5); 7.2628 (25.8); 7.1466 (1.0); 7.1285 (1.0); 5.2420 (0.7); 5.2246 (0.6); 5.2042 (1.0); 5.1861 (1.3); 5.1682 (0.9); 4.1489 (1.1); 4.1312 (3.1); 4.1134 (3.1); 4.0955 (1.1); 4.0815 (0.5); 4.0648 (0.9); 3.9657 (14.1); 3.9399 (6.9); 2.0476 (16.0); 1.6096 (0.6); 1.580530 (15.8); 1.4579 (6.0); 1.4410 (6.0); 1.3912 (0.5); 1.3550 (3.2); 1.3386 (3.0); 1.2784 (3.7); 1.2605 (7.2); 1.2427 (3.6); 0.9540 (0.7); 0.9358 (1.4); 0.9173 (0.7); -0.0002 (31.9); -0.0083 (1.7) I.2-47: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6402 (0.6); 8.6342 (0.7); 8.6117 (0.7); 8.1985 (0.7); 8.1631 (0.6); 7.8983 (0.7); 7.8929 (1.0); 7.8877 (0.6); 7.5308 (0.7); 7.2617 (22.6); 3.9551 (3.6); 2.0481 (0.6); 35 1.5505 (16.0); 1.4878 (1.4); 1.4712 (1.4); -0.0002 (27.9); -0.0083 (1.6) BCS241005-Abroad STR 212 I.2-49: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7005 (2.5); 8.6945 (3.0); 8.6441 (2.7); 8.6380 (2.2); 8.3330 (1.2); 8.3288 (2.2); 8.3248 (1.2); 8.2488 (3.6); 8.2205 (0.7); 8.2170 (1.1); 8.2136 (0.8); 8.2009 (0.8); 8.1973 (1.2); 8.1941 (0.8); 8.0172 (1.6); 7.8975 (0.7); 7.8943 (1.0); 7.8901 (0.7); 7.8783 (0.9); 7.8751 (1.1); 7.8709 (0.8); 7.6661 (1.2); 7.6467 (2.5); 7.6273 (1.3); 7.2627 (15.0); 6.1122 (0.6); 6.0956 (1.0); 6.0764 (0.7); 6.0282 (0.7); 6.0030 (0.8); 5.9862 (1.1); 5.9695 (0.6); 5.9604 (0.7); 5.9441 (0.6); 5.3147 (1.5); 5.2893 (1.4); 5.1289 (1.4); 5.0862 (1.3); 3.9539 (16.0); -0.0002 (10.8) I.2-50:1H-NMR (400.6 MHz, CDCl3): δ= 8.6882 (2.9); 8.6825 (3.2); 8.6338 (3.4); 8.6284 (2.7); 8.3150 (3.1); 8.2061 (1.8); 8.1866 (1.9); 8.1515 (1.1); 7.8869 (2.3); 7.8633 (7.3); 7.8600 (7.7); 7.7939 (3.2); 10 7.6524 (1.6); 7.6331 (2.6); 7.6138 (1.3); 7.5083 (1.3); 7.4892 (1.3); 7.2627 (9.2); 6.0595 (0.9); 6.0422 (1.8); 6.0241 (1.3); 5.9999 (0.9); 5.9843 (0.5); 5.9752 (0.9); 5.9580 (1.3); 5.9418 (0.7); 5.9327 (0.8); 5.9168 (0.6); 5.3017 (5.5); 5.2841 (2.5); 5.2592 (2.2); 5.1017 (2.3); 5.0596 (2.1); 3.9479 (16.0); 1.2560 (1.0); 0.8807 (0.6); -0.0002 (11.4); -0.0016 (11.2) 15 I.2-51: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6343 (2.8); 8.6283 (3.2); 8.5813 (3.2); 8.5754 (2.5); 8.3198 (2.8); 8.1973 (1.5); 8.1777 (1.6); 7.9471 (1.4); 7.9273 (2.0); 7.9213 (3.3); 7.9161 (2.9); 7.6644 (2.7); 7.6443 (4.2); 7.6391 (2.0); 7.6252 (1.3); 7.5374 (3.1); 7.5166 (2.3); 7.2633 (7.8); 7.2136 (1.0); 7.1927 (1.0); 5.6068 (0.5); 5.5879 (1.0); 5.5717 (1.0); 5.5523 (0.5); 5.3017 (5.7); 3.9499 (16.0); 2.0477 (1.1); 1.8592 (0.6); 1.8408 (1.0); 1.8227 (0.9); 1.8065 (0.7); 1.7839 (0.8); 1.7654 (1.2); 1.7474 (1.0); 1.7306 (0.7); 1.6078 (0.8); 1.2782 (0.7); 1.2607 (1.6); 1.2428 (0.6); 0.8816 (1.2); 0.8639 (0.6); 0.7835 (3.3); 0.7651 (6.7); 0.7465 (3.1); -0.0002 (9.8) I.2-52: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6419 (2.6); 8.6359 (3.2); 8.5927 (3.0); 8.5867 (2.4); 8.3230 (1.6); 8.3192 (2.5); 8.3152 (1.5); 8.2015 (1.3); 8.1850 (1.1); 8.1819 (1.4); 7.9352 (1.2); 7.9194 (1.1); 25 7.9160 (1.4); 7.7206 (1.8); 7.7167 (2.8); 7.7128 (1.7); 7.6670 (1.3); 7.6477 (2.2); 7.6283 (1.1); 7.5809 (1.9); 7.3795 (1.8); 7.2626 (9.1); 7.2219 (0.9); 7.2009 (0.9); 5.5897 (0.9); 5.5734 (0.9); 5.3016 (5.3); 3.9525 (16.0); 1.8474 (0.8); 1.8315 (0.7); 1.8133 (0.6); 1.7897 (0.6); 1.7712 (1.0); 1.7532 (0.8); 1.7364 (0.6); 1.5996 (4.6); 1.2637 (1.7); 0.8987 (0.8); 0.8821 (2.1); 0.8644 (0.9); 0.7889 (2.9); 0.7704 (6.2); 0.7519 (2.8); -0.0002 (11.1); -0.0083 (0.6) 30 I.2-53: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6768 (2.7); 8.6710 (3.2); 8.6238 (3.2); 8.6178 (2.5); 8.3159 (2.8); 8.2028 (1.5); 8.1832 (1.6); 7.9029 (3.0); 7.8979 (3.0); 7.8861 (1.6); 7.8668 (1.7); 7.6497 (2.7); 7.6296 (3.9); 7.6238 (2.0); 7.6113 (1.3); 7.5290 (3.1); 7.5082 (2.3); 7.4813 (1.1); 7.4617 (1.1); 7.2620 (18.4); 6.0715 (0.8); 6.0546 (1.5); 6.0359 (1.1); 5.9945 (0.8); 5.9792 (0.5); 5.9696 (0.8); 5.9529 (1.3); 5.9363 (0.7); 5.9273 (0.8); 5.9110 (0.7); 5.2738 (2.0); 5.2487 (1.9); 5.0953 (2.0); 5.0528 (1.8); 3.9464 (16.0); 2.1748 (0.6); 1.5693 (1.0); -0.0002 (22.8) BCS241005-Abroad STR 213 I.2-54: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6780 (2.6); 8.6721 (3.2); 8.6355 (3.2); 8.6295 (2.4); 8.3119 (2.6); 8.2049 (1.4); 8.1853 (1.5); 7.9942 (1.9); 7.9908 (3.0); 7.8797 (1.2); 7.8605 (1.5); 7.8393 (1.8); 7.8352 (2.7); 7.8310 (1.7); 7.7345 (1.9); 7.7306 (2.8); 7.7263 (1.6); 7.6515 (1.3); 7.6320 (2.3); 7.6128 (1.1); 7.4166 (0.9); 7.3981 (0.9); 7.2620 (26.9); 6.0529 (0.7); 6.0361 (1.3); 6.0175 (1.0); 5.9910 (0.8); 5.9661 (0.8); 5.9496 (1.2); 5.9331 (0.6); 5.9237 (0.8); 5.9077 (0.6); 5.2792 (1.9); 5.2542 (1.8); 5.0981 (1.8); 5.0557 (1.7); 3.9484 (16.0); 1.5616 (13.5); -0.0002 (32.9); -0.0082 (1.8) I.2-55:1H-NMR (400.6 MHz, CDCl3): δ= 8.6845 (1.0); 8.6785 (1.2); 8.6356 (1.2); 8.6296 (0.9); 8.3151 (1.0); 8.2073 (0.6); 8.1872 (0.6); 7.8601 (0.6); 7.7007 (1.1); 7.6535 (0.5); 7.6343 (0.9); 7.5634 (0.8); 10 7.3757 (0.8); 7.2617 (22.6); 6.0490 (0.5); 5.2841 (0.7); 5.2586 (0.6); 5.1024 (0.7); 5.0592 (0.6); 3.9494 (6.0); 1.5527 (16.0); -0.0002 (28.3); -0.0079 (1.6) I.2-56: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6824 (1.3); 8.1448 (1.3); 8.1241 (1.2); 8.1191 (1.1); 8.0925 (0.5); 7.8685 (0.6); 7.6481 (1.0); 7.6271 (1.4); 7.5871 (0.6); 7.5260 (1.4); 7.2617 (29.3); 3.9400 (2.2); 15 2.0480 (1.2); 1.5540 (16.0); 1.4362 (0.8); 1.3539 (1.0); 1.3404 (0.9); -0.0002 (34.7); -0.0081 (1.9) I.2-57:1H-NMR (400.6 MHz, CDCl3): δ= 8.6936 (7.7); 8.6876 (9.2); 8.6461 (8.9); 8.6400 (7.0); 8.3286 (7.7); 8.3231 (7.4); 7.8685 (5.3); 7.8608 (9.9); 7.8481 (5.3); 7.8425 (4.8); 7.6978 (8.1); 7.6770 (6.5); 7.6054 (6.0); 7.5096 (5.8); 7.4880 (3.2); 7.4690 (3.2); 7.2622 (77.8); 5.6905 (0.6); 5.6732 (2.4); 5.6554 20 (3.3); 5.6376 (2.4); 5.6210 (0.8); 5.3020 (0.6); 3.7753 (2.1); 3.7588 (5.5); 3.7423 (2.5); 1.8769 (2.1); 1.8604 (6.3); 1.8522 (3.0); 1.8439 (2.5); 1.4918 (15.2); 1.4750 (16.0); 1.4329 (1.1); 1.2564 (0.9); - 0.0002 (93.1); -0.1493 (0.7) I.2-58: δ= 8.7031 (13.8); 8.2351 (3.4); 8.1687 (6.1); 8.1456 (8.4); 7.8719 (4.9); 7.6792 (16.0); 7.6582 (15.2); 7.5988 (6.2); 7.5174 (7.3); 7.4550 (2.4); 7.2622 (160.4); 6.9979 (1.0); 5.3022 (4.4); 3.7716 (3.4); 3.7563 (8.9); 3.7400 (4.2); 2.1269 (2.3); 1.8755 (3.8); 1.8590 (9.8); 1.8504 (5.0); 1.8430 (4.2); 1.4707 (7.5); 1.4324 (3.8); 1.3810 (7.3); 1.2517 (1.7); -0.0002 (189.2); -0.1500 (1.5) I.2-59: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7183 (1.7); 8.7122 (2.8); 8.7064 (3.4); 8.7003 (4.0); 8.6932 30 (2.5); 8.6872 (1.6); 8.6624 (3.7); 8.6564 (2.8); 8.1211 (1.7); 8.1175 (1.7); 8.1016 (1.9); 8.0981 (1.8); 8.0764 (0.9); 8.0660 (1.1); 8.0528 (0.9); 7.7853 (1.7); 7.7814 (1.6); 7.7661 (2.1); 7.7625 (1.9); 7.7373 (2.7); 7.7175 (3.9); 7.5911 (3.2); 7.5713 (4.0); 7.5647 (3.1); 7.5525 (2.0); 7.5419 (3.4); 7.5317 (2.1); 7.4448 (1.6); 7.4259 (1.6); 7.3745 (1.7); 7.3592 (2.7); 7.2635 (17.9); 5.3021 (2.4); 5.2883 (0.9); 5.2714 (0.6); 5.2154 (1.1); 5.1976 (1.6); 5.1796 (1.1); 3.7839 (6.1); 3.7678 (14.4); 3.7519 (6.3); 3.6626 (0.5); 2.1275 (4.2); 1.8988 (0.7); 1.8815 (6.1); 1.8735 (7.5); 1.8653 (16.0); 1.8570 (7.4); 1.8492 (6.0); 1.8323 (1.0); 1.5177 (6.5); 1.5007 (6.6); 1.4328 (0.7); 1.3840 (3.8); 1.3674 (3.8); 0.9376 (0.6); -0.0002 (21.7) BCS241005-Abroad STR 214 I.2-60: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6910 (5.6); 8.6850 (7.1); 8.6533 (6.8); 8.6472 (5.0); 8.2885 (4.1); 8.2850 (6.4); 8.2814 (3.7); 8.2013 (4.1); 8.1971 (5.5); 8.1930 (3.5); 7.9537 (4.0); 7.9493 (5.9); 7.9448 (3.4); 7.7223 (4.0); 7.7185 (6.0); 7.7146 (3.6); 7.5658 (4.4); 7.5406 (2.6); 7.5213 (2.7); 7.3540 (4.1); 7.2629 (26.8); 5.6466 (1.7); 5.6290 (2.4); 5.6111 (1.8); 5.5940 (0.5); 5.3021 (0.8); 3.7781 (5.8); 3.7618 (14.2); 3.7559 (6.2); 3.7454 (6.1); 1.8959 (0.6); 1.8787 (5.8); 1.8709 (6.9); 1.8624 (16.0); 1.8540 (7.0); 1.8461 (5.9); 1.8292 (0.9); 1.5346 (11.2); 1.5178 (11.4); 1.4328 (0.5); -0.0002 (32.0); -0.0083 (1.9) I.2-61: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6937 (4.6); 8.6890 (5.2); 8.6424 (5.4); 8.6370 (4.2); 8.3421 10 (4.9); 8.3375 (4.6); 8.0593 (5.0); 8.0561 (4.9); 7.8686 (2.4); 7.8646 (2.2); 7.8481 (2.9); 7.8439 (2.7); 7.6870 (7.0); 7.6665 (6.3); 7.5676 (2.5); 7.5484 (2.7); 7.4905 (4.7); 7.4699 (3.9); 7.2637 (14.2); 7.2622 (13.3); 5.6734 (1.7); 5.6553 (2.4); 5.6381 (1.6); 5.3020 (1.1); 3.7776 (7.0); 3.7628 (15.4); 3.7465 (7.1); 2.1224 (3.3); 1.8948 (0.9); 1.8775 (6.6); 1.8690 (8.8); 1.8622 (16.0); 1.8538 (8.5); 1.8460 (6.4); 1.8288 (1.1); 1.4937 (10.1); 1.4770 (10.2); 1.4324 (0.8); 1.2554 (0.9); 1.2398 (0.6); -0.0002 (17.0); -0.0017 15 (16.4) I.2-62: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6977 (3.1); 8.6673 (1.3); 8.2478 (0.9); 8.1480 (1.6); 8.1286 (2.2); 8.0874 (0.9); 8.0511 (1.0); 7.6849 (1.1); 7.6647 (4.2); 7.6437 (3.4); 7.5802 (0.5); 7.5211 (0.8); 7.4960 (1.3); 7.2633 (16.3); 5.3021 (4.3); 3.7744 (6.3); 3.7587 (14.6); 3.7425 (6.4); 2.1211 (1.1); 1.8938 20 (1.0); 1.8764 (6.2); 1.8682 (7.8); 1.8603 (16.0); 1.8520 (7.6); 1.8441 (6.0); 1.8272 (1.0); 1.4909 (1.7); 1.4769 (1.8); 1.4325 (0.7); 1.3825 (1.6); -0.0002 (20.0) I.2-63: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6953 (6.3); 8.6820 (6.9); 8.6759 (9.1); 8.6700 (8.9); 8.6494 (8.3); 8.6435 (5.5); 8.1086 (3.3); 8.0925 (4.1); 8.0322 (2.3); 8.0204 (3.6); 8.0083 (2.4); 7.9052 (5.2); 25 7.8906 (7.0); 7.8863 (6.8); 7.7666 (3.5); 7.7483 (4.2); 7.6674 (2.1); 7.6476 (3.2); 7.6276 (3.5); 7.6079 (4.8); 7.5857 (4.8); 7.5659 (7.0); 7.5436 (9.6); 7.5324 (8.8); 7.5212 (10.0); 7.5005 (5.4); 7.2618 (276.0); 7.2220 (5.1); 7.2024 (4.4); 6.9988 (1.8); 5.2670 (2.1); 5.2502 (1.7); 5.2178 (2.3); 5.1991 (3.2); 5.1821 (2.4); 3.7700 (4.4); 3.7547 (11.0); 3.7391 (4.7); 2.1215 (5.8); 1.8739 (5.4); 1.8581 (12.9); 1.8499 (7.0); 1.8420 (5.5); 1.6737 (2.8); 1.4929 (15.5); 1.4762 (16.0); 1.4334 (2.8); 1.3833 (11.4); 1.3666 (11.2); 30 1.2544 (2.4); 0.1462 (1.7); -0.0002 (331.6); -0.1491 (2.0) I.2-64: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6457 (1.0); 8.6244 (1.0); 7.5206 (0.8); 7.2616 (132.5); 6.9982 (0.9); 5.3023 (1.0); 3.7485 (1.0); 2.1098 (1.0); 1.8549 (1.4); 1.5540 (16.0); 1.4993 (3.4); 1.4827 (2.9); 1.4324 (3.9); 1.2556 (3.4); 1.2437 (2.6); 1.2224 (1.7); 0.8800 (0.9); 0.1459 (1.2); -0.0002 (154.1); 35 -0.1496 (1.1) BCS241005-Foreign STR 215 I.2-65: 1H-NMR (400.6 MHz, d6-DMSO): δ= 9.2956 (0.8); 9.2783 (0.9); 8.7128 (1.4); 8.7068 (2.2); 8.6910 (2.3); 8.6850 (1.4); 8.1588 (2.6); 8.1537 (2.0); 8.0640 (0.8); 8.0444 (0.9); 7.9550 (0.8); 7.9357 (0.9); 7.8328 (1.4); 7.8119 (1.9); 7.7046 (1.1); 7.6989 (1.4); 7.6835 (1.0); 7.6783 (2.1); 7.6588 (0.7); 6.1676 (0.7); 5.8212 (0.8); 5.2486 (1.0); 5.2229 (0.9); 5.0219 (0.9); 4.9787 (0.9); 3.8419 (8.7); 3.3320 5 (16.0); 2.6710 (0.5); 2.5067 (64.6); 2.5023 (83.8); 2.4979 (60.9); 2.4937 (30.5); 2.3293 (0.6); -0.0002 (28.9); -0.0083 (1.7) I.2-66: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1342 (0.8); 9.1805 (2.8); 9.1642 (2.8); 8.6811 (5.7); 8.6651 (5.9); 8.3216 (1.8); 8.1736 (5.1); 8.0396 (3.5); 8.0194 (16.0); 7.9313 (2.8); 7.9122 (3.1); 7.6595 10 (2.0); 7.6405 (3.4); 7.6215 (1.8); 5.2971 (1.7); 5.2803 (2.5); 5.2636 (1.7); 3.3390 (6.1); 2.6757 (0.6); 2.5052 (85.0); 2.3331 (0.7); 1.4861 (8.9); 1.4694 (8.9); 1.2423 (4.3); 0.8572 (3.2); 0.8403 (1.7); -0.0002 (5.7) I.2-67: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6554 (2.6); 8.6494 (3.1); 8.6014 (3.1); 8.5954 (2.5); 8.2876 15 (2.6); 8.2040 (1.4); 8.1845 (1.5); 7.8730 (1.2); 7.8538 (1.5); 7.7849 (10.9); 7.6611 (1.3); 7.6417 (2.3); 7.6224 (1.1); 7.3390 (0.8); 7.3190 (0.9); 7.2622 (17.4); 5.6219 (0.9); 5.6039 (1.1); 5.5860 (0.9); 3.9498 (16.0); 2.0477 (0.6); 1.5698 (9.5); 1.4445 (6.1); 1.4278 (6.2); -0.0002 (21.5); -0.0081 (1.2) I.2-68: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1241 (2.9); 9.0933 (4.1); 9.0770 (4.1); 8.6735 (8.3); 20 8.6579 (8.7); 8.3219 (1.9); 8.1922 (7.6); 8.0496 (11.5); 8.0288 (5.0); 7.9517 (4.2); 7.9334 (4.6); 7.7783 (3.3); 7.7577 (5.6); 7.7108 (7.1); 7.6897 (4.2); 7.6653 (3.4); 7.6461 (5.3); 7.6270 (2.7); 5.3039 (2.5); 5.2868 (3.6); 5.2707 (2.4); 3.3414 (16.0); 2.6728 (1.1); 2.5057 (98.6); 2.3326 (1.1); 1.4757 (13.3); 1.4588 (13.0); 1.2436 (6.2); 0.8716 (2.5); 0.8571 (4.6); 0.8403 (2.3); -0.0002 (7.1) 25 I.2-69: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1289 (1.1); 9.1000 (2.4); 9.0835 (2.6); 8.6763 (3.9); 8.6706 (5.7); 8.6555 (6.0); 8.6496 (3.9); 8.3210 (2.4); 8.1912 (4.8); 8.1691 (5.0); 8.1644 (4.8); 8.0491 (2.5); 8.0296 (2.8); 7.9497 (2.4); 7.9303 (2.7); 7.8301 (3.3); 7.8092 (4.7); 7.7100 (2.9); 7.7054 (2.7); 7.6891 (2.3); 7.6847 (2.1); 7.6649 (2.2); 7.6456 (3.6); 7.6265 (1.8); 5.2946 (1.5); 5.2782 (2.2); 5.2612 (1.5); 3.3375 (16.0); 2.6725 (0.6); 2.5039 (105.3); 2.3307 (0.8); 1.4694 (8.2); 1.4525 (8.3); 1.2443 (2.6); 30 0.8732 (1.0); 0.8576 (2.4); 0.8400 (1.1); -0.0002 (10.1) I.2-70: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1155 (0.7); 9.1816 (0.8); 9.1651 (0.8); 8.6823 (1.7); 8.6612 (1.6); 8.1721 (1.6); 8.1478 (1.8); 8.0368 (2.2); 8.0236 (1.0); 7.9317 (0.8); 7.9135 (0.8); 7.6602 (0.6); 7.6422 (1.0); 5.2737 (0.7); 3.3346 (16.0); 2.6693 (1.6); 2.5695 (3.2); 2.5024 (72.0); 1.4817 (2.6); 35 1.4652 (2.4); 1.2438 (1.0); 0.8576 (0.7); -0.0002 (5.1) BCS241005-Abroad STR 216 I.2-71: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6345 (2.7); 8.6286 (3.4); 8.5909 (3.2); 8.5850 (2.5); 8.3484 (2.8); 8.1997 (1.4); 8.1801 (1.6); 7.9794 (1.3); 7.9603 (1.5); 7.8775 (3.1); 7.6759 (1.4); 7.6565 (2.6); 7.6444 (2.4); 7.6380 (2.1); 7.5394 (2.1); 7.2630 (9.3); 7.1608 (1.0); 7.1380 (1.1); 5.5485 (1.1); 5.5294 (1.4); 5.5261 (1.3); 5.5069 (1.1); 5.3018 (8.2); 3.9581 (16.0); 2.0340 (0.6); 2.0168 (1.0); 1.9995 (1.0); 5 1.9822 (0.6); 1.5977 (3.0); 1.2617 (0.6); 0.8863 (6.5); 0.8695 (6.3); 0.6474 (6.0); 0.6305 (6.0); -0.0002 (11.6); -0.0081 (0.8) I.2-72: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6304 (2.7); 8.6245 (3.2); 8.5757 (3.2); 8.5697 (2.5); 8.3752 (2.7); 8.1887 (1.4); 8.1690 (1.6); 7.9946 (1.3); 7.9757 (1.5); 7.9271 (2.9); 7.9222 (2.8); 7.6706 (1.4); 10 7.6655 (1.3); 7.6497 (3.1); 7.6448 (1.9); 7.6304 (2.5); 7.6110 (1.2); 7.5395 (3.1); 7.5188 (2.3); 7.2620 (23.6); 5.1396 (1.1); 5.1192 (2.1); 5.0986 (1.1); 3.9517 (16.0); 1.5705 (3.0); 1.2629 (1.7); 1.2167 (0.6); 1.2043 (0.9); 1.1919 (0.7); 1.1843 (0.9); 1.1711 (0.6); 0.8985 (0.8); 0.8819 (1.9); 0.8643 (0.9); 0.5195 (0.7); 0.5097 (0.8); 0.4943 (0.7); 0.4055 (0.6); 0.3937 (0.7); 0.3850 (0.8); 0.3729 (1.0); 0.3613 (0.8); 0.3526 (0.8); 0.3383 (1.0); 0.3260 (1.0); 0.3137 (0.7); 0.0577 (0.8); 0.0455 (0.9); 0.0336 (1.0); 0.0211 15 (1.0); -0.0002 (28.1) I.2-73: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6499 (2.8); 8.6439 (3.2); 8.5959 (3.2); 8.5900 (2.5); 8.3896 (2.7); 8.2704 (5.1); 8.2018 (1.4); 8.1820 (1.6); 8.0253 (2.2); 7.9910 (1.3); 7.9716 (1.5); 7.6636 (1.3); 7.6443 (2.4); 7.6250 (1.2); 7.3978 (0.9); 7.3778 (0.9); 7.2621 (19.7); 5.1582 (1.0); 5.1374 (2.0); 5.1168 20 (1.1); 3.9589 (16.0); 1.5750 (11.2); 1.3031 (1.3); 1.2638 (6.4); 1.2281 (1.3); 1.2158 (0.8); 1.2081 (0.5); 0.8985 (2.9); 0.8819 (7.4); 0.8643 (3.4); 0.5630 (0.6); 0.5524 (0.8); 0.5374 (0.7); 0.4365 (0.6); 0.4249 (0.6); 0.4161 (0.8); 0.4040 (0.9); 0.3892 (0.6); 0.3835 (0.7); 0.3765 (0.8); 0.3663 (0.9); 0.3538 (1.0); 0.3415 (0.7); 0.0712 (0.7); 0.0588 (0.8); 0.0466 (0.9); 0.0342 (0.7); -0.0002 (23.8); -0.0082 (1.4) 25 I.2-74: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6250 (2.8); 8.6191 (3.3); 8.5776 (3.2); 8.5717 (2.4); 8.3482 (2.6); 8.1952 (1.4); 8.1755 (1.5); 7.9926 (1.2); 7.9731 (1.4); 7.9399 (2.9); 7.9349 (2.8); 7.6828 (1.4); 7.6776 (1.5); 7.6733 (1.5); 7.6620 (2.1); 7.6546 (2.8); 7.6344 (1.2); 7.5512 (3.1); 7.5304 (2.3); 7.2619 (26.8); 7.1487 (0.9); 7.1258 (1.0); 5.5514 (1.0); 5.5328 (1.3); 5.5287 (1.2); 5.5100 (1.0); 3.9560 (16.0); 2.0232 (0.5); 2.0060 (0.9); 1.9888 (0.9); 1.9713 (0.6); 1.5629 (11.7); 0.8795 (6.2); 0.8627 (6.0); 0.643530 (5.8); 0.6267 (5.7); -0.0002 (33.5); -0.0084 (1.8) BCS241005-Abroad STR 217 I.2-75: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6630 (2.5); 8.6570 (3.1); 8.6018 (2.6); 8.5958 (2.2); 8.3421 (1.1); 8.3380 (2.0); 8.3342 (1.1); 8.2682 (3.3); 8.2163 (0.7); 8.2130 (1.0); 8.2093 (0.7); 8.1968 (0.8); 8.1932 (1.1); 8.1898 (0.8); 8.0209 (1.4); 7.9586 (0.7); 7.9544 (0.9); 7.9512 (0.7); 7.9394 (0.8); 7.9350 (1.0); 7.9320 (0.8); 7.6807 (1.1); 7.6613 (1.9); 7.6419 (0.9); 7.4019 (0.6); 7.3812 (0.6); 7.2632 (8.2); 5.6316 (0.7); 5.6152 (0.6); 5.6115 (0.5); 5.3019 (16.0); 3.9575 (16.0); 1.8822 (0.7); 1.8665 (0.6); 1.8634 (0.6); 1.8480 (0.5); 1.8430 (0.7); 1.8243 (0.9); 1.8059 (0.7); 1.2557 (0.6); 0.8154 (2.4); 0.7969 (5.4); 0.7783 (2.3); -0.0002 (11.0) I.2-76: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6499 (2.5); 8.6438 (3.0); 8.5937 (2.7); 8.5876 (2.2); 8.3247 10 (1.1); 8.3206 (2.1); 8.3163 (1.2); 8.2042 (0.8); 8.2011 (1.1); 8.1973 (0.7); 8.1847 (0.9); 8.1815 (1.2); 8.1777 (0.8); 8.1658 (0.7); 8.1614 (0.7); 7.9520 (0.7); 7.9488 (1.0); 7.9446 (0.7); 7.9328 (0.9); 7.9296 (1.1); 7.9255 (0.8); 7.8819 (5.7); 7.8775 (6.1); 7.8013 (1.7); 7.7970 (2.8); 7.7926 (1.3); 7.6674 (1.2); 7.6480 (2.0); 7.6287 (1.0); 7.2636 (10.8); 7.2403 (0.7); 5.5666 (0.7); 5.5504 (0.7); 5.3021 (5.2); 3.9526 (16.0); 1.8452 (0.8); 1.8294 (0.6); 1.8266 (0.7); 1.8110 (0.6); 1.8028 (0.7); 1.7842 (1.0); 1.7659 (0.7); 15 1.7495 (0.5); 0.7911 (2.6); 0.7727 (5.6); 0.7541 (2.4); -0.0002 (3.1) I.2-77: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6422 (2.7); 8.6363 (3.2); 8.5938 (3.2); 8.5879 (2.5); 8.3194 (2.7); 8.2016 (1.4); 8.1821 (1.5); 7.9361 (1.3); 7.9168 (1.5); 7.8667 (2.0); 7.8632 (3.0); 7.6672 (1.4); 7.6478 (2.5); 7.6279 (2.7); 7.5304 (2.0); 7.2632 (7.5); 7.2132 (1.0); 7.1926 (1.0); 5.5865 (1.0); 5.5703 20 (1.0); 5.5509 (0.5); 5.3018 (7.8); 3.9525 (16.0); 1.8654 (0.5); 1.8470 (0.9); 1.8305 (0.8); 1.8128 (0.7); 1.7923 (0.8); 1.7736 (1.1); 1.7556 (0.9); 1.7388 (0.6); 1.6098 (2.2); 1.2634 (1.0); 0.8818 (1.2); 0.8641 (0.5); 0.7891 (3.2); 0.7706 (6.6); 0.7521 (3.0); -0.0002 (9.3); -0.0077 (0.6) I.2-78:1H-NMR (400.6 MHz, CDCl3): δ= 8.6288 (2.7); 8.6230 (3.4); 8.5910 (3.4); 8.5852 (2.6); 8.3438 25 (2.9); 8.1957 (1.6); 8.1765 (1.7); 8.0279 (3.3); 7.9779 (1.5); 7.9589 (1.7); 7.8491 (3.0); 7.7630 (3.1); 7.6717 (1.4); 7.6525 (2.6); 7.6331 (1.3); 7.2617 (26.8); 7.0974 (1.2); 7.0739 (1.2); 5.5251 (1.2); 5.5033 (1.5); 5.4834 (1.2); 3.9574 (16.0); 2.0302 (0.6); 2.0126 (1.1); 1.9948 (1.1); 1.9780 (0.7); 1.5599 (10.8); 1.3032 (0.6); 1.2632 (2.5); 0.8852 (7.8); 0.8684 (7.1); 0.6369 (6.5); 0.6200 (6.3); -0.0002 (33.7) 30 I.2-79: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6475 (2.9); 8.6415 (3.3); 8.6007 (3.2); 8.5948 (2.5); 8.3689 (1.8); 8.3649 (2.7); 8.3610 (1.5); 8.2794 (4.8); 8.2102 (1.4); 8.1905 (1.5); 8.0329 (2.1); 7.9861 (1.3); 7.9702 (1.2); 7.9667 (1.4); 7.6873 (1.3); 7.6680 (2.3); 7.6486 (1.1); 7.2861 (0.9); 7.2639 (6.9); 5.5950 (1.0); 5.5758 (1.4); 5.5727 (1.2); 5.5533 (1.0); 5.3017 (5.8); 3.9630 (16.0); 2.0715 (0.5); 2.0543 (0.9); 2.0369 (0.9); 2.0195 (0.6); 1.6427 (2.5); 1.2637 (2.3); 0.9117 (6.1); 0.8949 (6.7); 0.8817 (3.2); 0.864035 (1.4); 0.6627 (5.8); 0.6458 (5.7); -0.0002 (7.4) BCS241005-Abroad STR 218 I.2-80: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6857 (2.7); 8.6797 (3.2); 8.6365 (3.2); 8.6305 (2.4); 8.3149 (2.6); 8.2072 (1.5); 8.1880 (1.5); 7.8804 (1.4); 7.8609 (1.8); 7.8481 (3.0); 7.6538 (1.4); 7.6347 (2.5); 7.6061 (2.2); 7.5245 (2.2); 7.4904 (1.1); 7.4704 (1.1); 7.2618 (51.8); 6.0650 (0.7); 6.0480 (1.4); 6.0294 (1.0); 5.9941 (0.8); 5.9778 (0.5); 5.9691 (0.8); 5.9523 (1.2); 5.9355 (0.6); 5.9265 (0.8); 5.9106 (0.6); 5 5.2865 (1.9); 5.2615 (1.7); 5.1029 (1.8); 5.0604 (1.8); 3.9492 (16.0); 1.5595 (9.5); 0.0692 (1.0); -0.0002 (63.2); -0.0081 (3.3) I.2-81: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6342 (2.8); 8.6283 (3.4); 8.5897 (3.2); 8.5838 (2.5); 8.3528 (1.7); 8.3490 (2.6); 8.3449 (1.5); 8.2000 (1.4); 8.1805 (1.5); 7.9798 (1.2); 7.9638 (1.2); 7.9604 (1.4); 10 7.7355 (1.9); 7.7317 (2.9); 7.7277 (1.7); 7.6764 (1.3); 7.6570 (2.4); 7.6377 (1.1); 7.6026 (2.0); 7.3892 (1.9); 7.2630 (8.9); 7.1695 (0.9); 7.1469 (1.0); 5.5532 (1.0); 5.5344 (1.3); 5.5306 (1.2); 5.5119 (1.0); 5.3018 (2.5); 3.9583 (16.0); 2.0328 (0.5); 2.0158 (0.9); 1.9987 (0.9); 1.9812 (0.6); 1.5999 (3.6); 1.2637 (1.8); 0.8981 (1.0); 0.8851 (6.9); 0.8683 (6.4); 0.6496 (5.8); 0.6327 (5.7); -0.0002 (11.2); -0.0083 (0.6) 15 I.2-82: 1H-NMR (400.6 MHz, CDCl3): δ= 8.7183 (2.7); 8.7123 (2.9); 8.6442 (3.0); 8.6383 (2.5); 8.5477 (2.0); 8.3352 (2.7); 8.2645 (5.0); 8.2204 (1.4); 8.2009 (1.6); 8.1209 (0.9); 8.0135 (2.2); 7.9078 (1.3); 7.8885 (1.5); 7.7781 (1.0); 7.7585 (1.0); 7.6710 (1.3); 7.6515 (2.3); 7.6323 (1.1); 7.2620 (21.0); 6.1251 (0.7); 6.1073 (1.3); 6.0891 (1.0); 6.0473 (0.7); 6.0220 (0.8); 6.0053 (1.2); 5.9888 (0.6); 5.9794 (0.8); 5.9634 (0.6); 5.3268 (1.9); 5.3019 (5.8); 5.1387 (1.8); 5.0958 (1.6); 3.9537 (16.0); 3.9326 (0.6); 2.0119 20 (1.7); 1.2553 (0.5); -0.0002 (25.8); -0.0083 (1.7) I.2-83: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6989 (2.7); 8.6930 (3.1); 8.6439 (3.2); 8.6380 (2.5); 8.3283 (2.8); 8.2453 (5.6); 8.2167 (1.7); 8.1970 (1.7); 8.0173 (2.4); 7.8924 (1.4); 7.8731 (1.6); 7.6652 (1.5); 7.6458 (2.6); 7.6268 (2.1); 7.6093 (1.1); 7.2625 (9.9); 6.1098 (0.8); 6.0924 (1.5); 6.0741 (1.0); 6.0259 25 (0.8); 6.0096 (0.5); 6.0009 (0.8); 5.9839 (1.3); 5.9673 (0.7); 5.9580 (0.8); 5.9419 (0.6); 5.3127 (2.2); 5.3017 (4.0); 5.2877 (2.0); 5.1281 (2.0); 5.0856 (1.8); 3.9537 (16.0); 1.2555 (0.9); -0.0002 (12.3) I.2-84: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6424 (2.8); 8.6365 (3.2); 8.5931 (3.2); 8.5873 (2.5); 8.3191 (2.9); 8.2019 (1.6); 8.1826 (1.7); 7.9352 (1.4); 7.9158 (1.6); 7.7165 (3.1); 7.6672 (1.5); 7.6479 (2.5); 30 7.6286 (1.2); 7.5806 (2.4); 7.3794 (2.3); 7.2622 (15.3); 7.2196 (1.2); 7.1979 (1.2); 5.6086 (0.6); 5.5902 (1.2); 5.5729 (1.1); 5.5542 (0.6); 5.3019 (3.8); 3.9526 (16.0); 1.8658 (0.6); 1.8472 (1.0); 1.8293 (1.0); 1.8133 (0.8); 1.7893 (0.8); 1.7709 (1.2); 1.7530 (1.0); 1.7361 (0.7); 1.5755 (5.2); 0.7887 (3.5); 0.7703 (6.9); 0.7517 (3.1); -0.0002 (18.8) 35 BCS241005-Abroad STR 219 I.2-85: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6424 (2.6); 8.6365 (3.1); 8.5934 (3.0); 8.5874 (2.4); 8.3229 (1.6); 8.3192 (2.5); 8.3150 (1.5); 8.2018 (1.3); 8.1854 (1.1); 8.1823 (1.4); 7.9353 (1.2); 7.9194 (1.1); 7.9160 (1.3); 7.7205 (1.8); 7.7167 (2.8); 7.7127 (1.7); 7.6677 (1.3); 7.6483 (2.3); 7.6290 (1.1); 7.5807 (1.9); 7.3801 (1.8); 7.2623 (16.1); 7.2193 (0.9); 7.1979 (0.9); 5.5899 (0.9); 5.5737 (0.9); 5.3020 (5.3); 5.39527 (16.0); 2.0111 (4.0); 1.8474 (0.8); 1.8317 (0.7); 1.8131 (0.6); 1.7895 (0.7); 1.7711 (1.0); 1.7529 (0.8); 1.7364 (0.6); 1.5772 (5.2); 0.7889 (2.9); 0.7704 (6.2); 0.7519 (2.8); -0.0002 (19.7); -0.0082 (1.1) I.2-86: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6300 (2.7); 8.6241 (3.4); 8.5912 (3.2); 8.5853 (2.4); 8.3444 (2.7); 8.1968 (1.4); 8.1771 (1.5); 7.9762 (1.2); 7.9568 (1.4); 7.8906 (6.3); 7.8863 (6.5); 7.8158 (2.1); 10 7.8115 (3.1); 7.8072 (1.5); 7.6724 (1.3); 7.6531 (2.4); 7.6337 (1.1); 7.2620 (21.0); 7.1108 (0.9); 7.0876 (1.0); 5.5289 (1.0); 5.5098 (1.4); 5.4871 (1.0); 3.9578 (16.0); 2.0476 (0.8); 2.0313 (0.6); 2.0137 (0.9); 1.9965 (0.9); 1.9794 (0.6); 1.5660 (8.2); 1.2613 (1.9); 0.8980 (1.1); 0.8855 (6.9); 0.8687 (6.4); 0.6391 (5.8); 0.6222 (5.8); -0.0002 (26.2); -0.0083 (1.5) 15 I.2-87: 1H-NMR (400.6 MHz, d6-DMSO): δ= 9.1846 (2.1); 9.1682 (2.1); 8.6843 (3.5); 8.6783 (5.3); 8.6639 (5.6); 8.6578 (3.3); 8.1754 (4.0); 8.0422 (2.1); 8.0226 (2.5); 7.9786 (16.0); 7.9270 (2.0); 7.9076 (2.2); 7.6558 (1.8); 7.6365 (3.2); 7.6172 (1.5); 5.2962 (1.2); 5.2796 (1.9); 5.2627 (1.3); 3.3370 (0.6); 2.5097 (43.0); 2.5055 (53.0); 2.5012 (38.8); 1.4834 (7.0); 1.4663 (7.0); -0.0002 (26.0); -0.0082 (1.8) 20 I.2-88: 1H-NMR (400.6 MHz, d6-DMSO): δ= 8.7130 (0.7); 8.7071 (1.0); 8.6915 (1.0); 8.6856 (0.6); 8.1607 (0.8); 8.0230 (0.8); 8.0182 (0.8); 7.8501 (0.6); 7.8294 (0.8); 7.6772 (0.8); 3.8401 (3.9); 3.3342 (16.0); 2.5061 (27.9); 2.5025 (34.5); -0.0002 (5.0) I.2-89: 1H-NMR (400.6 MHz, d6-DMSO): δ= 13.1234 (1.0); 9.3163 (5.7); 9.2990 (6.0); 8.7891 (0.6); 25 8.7060 (8.3); 8.7001 (14.0); 8.6884 (14.6); 8.6824 (8.1); 8.1762 (10.4); 8.0594 (5.8); 8.0430 (15.6); 8.0388 (16.0); 7.9231 (5.4); 7.9042 (6.2); 7.8485 (8.7); 7.8275 (11.4); 7.6875 (6.7); 7.6823 (7.0); 7.6775 (6.1); 7.6668 (6.1); 7.6585 (10.1); 7.6388 (4.4); 7.5080 (0.5); 6.1977 (1.9); 6.1807 (2.2); 6.1722 (2.4); 6.1549 (4.5); 6.1382 (2.6); 6.1289 (2.4); 6.1124 (2.5); 5.8538 (3.1); 5.8371 (5.6); 5.8203 (3.0); 5.2461 (6.3); 5.2206 (6.0); 5.0070 (6.0); 4.9641 (5.7); 4.6306 (0.9); 3.6330 (3.1); 2.6717 (2.8); 2.5069 (342.8); 2.5030 (428.8); 2.3305 (4.5); 0.1451 (0.9); 0.0295 (1.0); -0.0002 (157.6); -0.1493 (1.1) BCS241005-Foreign STR 220 I.2-90: 1H-NMR (400.6 MHz, d6-DMSO): δ= 9.0978 (1.2); 9.0812 (1.2); 8.6765 (2.0); 8.6704 (3.5); 8.6584 (3.6); 8.6524 (2.0); 8.1999 (2.4); 8.0445 (1.2); 8.0251 (1.4); 7.9707 (1.1); 7.9513 (1.3); 7.6617 (1.2); 7.6422 (3.7); 7.6385 (2.9); 7.6232 (1.1); 7.5364 (1.8); 7.2884 (1.8); 5.3379 (0.7); 5.3211 (1.1); 5.3038 (0.7); 3.3356 (16.0); 2.5079 (50.2); 2.5036 (63.7); 2.4992 (45.5); 1.9904 (1.7); 1.9105 (1.3); 1.4898 (4.2); 1.4725 (4.2); 1.4160 (0.8); 1.3962 (10.9); 1.3556 (1.7); 1.1927 (0.5); 1.1811 (0.6); 1.1749 (1.2); 1.1696 (1.0); 1.1571 (0.5); 0.9434 (1.0); 0.9300 (2.7); 0.8315 (1.1); 0.8217 (3.3); 0.8164 (2.8); 0.8082 (0.8); -0.0002 (12.2); -0.0084 (0.7) I.2-91: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6449 (2.7); 8.6389 (3.2); 8.5926 (3.1); 8.5866 (2.5); 8.2956 10 (2.7); 8.1998 (1.4); 8.1803 (1.5); 8.1097 (2.9); 7.8883 (1.3); 7.8691 (1.5); 7.7819 (2.1); 7.7646 (2.1); 7.6606 (1.4); 7.6412 (2.4); 7.6219 (1.1); 7.4613 (1.0); 7.4421 (1.1); 7.2643 (10.6); 6.3418 (0.7); 5.6513 (0.9); 5.6338 (1.2); 5.6157 (0.9); 5.3022 (8.2); 4.0813 (0.5); 4.0646 (1.1); 4.0477 (0.6); 3.9461 (16.0); 3.0441 (7.2); 3.0320 (7.2); 2.0479 (4.3); 1.6468 (6.0); 1.6277 (0.5); 1.6100 (0.6); 1.4661 (6.0); 1.4494 (6.0); 1.2601 (0.8); 1.2447 (0.5); 0.9539 (0.9); 0.9355 (1.7); 0.9171 (0.8); -0.0002 (11.7); -0.0081 (0.7) 15 I.2-92: 1H-NMR (400 MHz, CDCl3): δ= 8.6419 (2.6); 8.6360 (3.2); 8.5973 (3.1); 8.5913 (2.4); 8.2995 (2.5); 8.2007 (1.3); 8.1810 (1.4); 7.9173 (1.2); 7.8979 (1.4); 7.6621 (1.2); 7.6426 (2.2); 7.6233 (1.1); 7.5986 (1.8); 7.5949 (2.9); 7.5911 (1.7); 7.4012 (1.8); 7.2829 (0.9); 7.2617 (35.4); 7.2172 (2.0); 5.6529 (0.8); 5.6362 (1.1); 5.6171 (0.8); 3.9453 (16.0); 1.5600 (13.0); 1.4631 (5.9); 1.4464 (6.1); 1.4286 (12.1);20 0.9222 (0.9); 0.9059 (3.1); 0.8958 (1.5); 0.8334 (1.9); 0.8235 (3.5); 0.8068 (1.1); -0.0002 (38.0); - 0.0084 (2.0) I.2-93: 1H-NMR (400 MHz, CDCl3): δ= 8.6849 (0.6); 8.6789 (0.8); 8.6625 (0.8); 8.3179 (0.6); 8.2101 (0.5); 3.3326 (16.0); 2.8002 (1.2); 2.7890 (1.2); 2.5108 (21.1); 2.5067 (39.4); 2.5023 (50.0); 2.4979 25 (35.8); 2.4937 (17.6); 1.4993 (0.9); 1.4823 (0.9); -0.0002 (8.9); -0.0081 (0.5) I.2-94: 1H-NMR (400 MHz, CDCl3): δ= 8.6838 (2.2); 8.6783 (2.5); 8.6349 (2.7); 8.6292 (2.1); 8.3151 (2.7); 8.2069 (1.5); 8.1874 (1.6); 7.8798 (1.3); 7.8602 (1.5); 7.7013 (2.9); 7.6533 (1.4); 7.6340 (2.4); 7.6147 (1.2); 7.5632 (2.2); 7.4943 (1.0); 7.4755 (1.1); 7.3740 (2.1); 7.2622 (16.0); 6.0653 (0.8); 6.0481 30 (1.4); 6.0300 (1.0); 5.9913 (0.8); 5.9752 (0.5); 5.9662 (0.8); 5.9496 (1.2); 5.9329 (0.6); 5.9238 (0.8); 5.9076 (0.6); 5.3019 (2.3); 5.2834 (2.0); 5.2586 (1.8); 5.1015 (1.9); 5.0593 (1.8); 3.9492 (16.0); 1.5718 (14.6); -0.0002 (18.1); -0.0083 (0.8) BCS241005-Abroad STR 221 I.2-95: 1H-NMR (400 MHz, CDCl3): δ= 8.6839 (2.1); 8.6783 (2.4); 8.6349 (2.6); 8.6292 (2.1); 8.3153 (2.7); 8.2067 (1.4); 8.1872 (1.5); 7.8800 (1.3); 7.8607 (1.5); 7.7016 (2.9); 7.6535 (1.4); 7.6341 (2.4); 7.6147 (1.1); 7.5635 (2.2); 7.4971 (1.0); 7.4777 (1.0); 7.3744 (2.0); 7.2626 (11.2); 6.0656 (0.7); 6.0485 (1.4); 6.0301 (1.0); 5.9915 (0.7); 5.9665 (0.8); 5.9497 (1.2); 5.9332 (0.6); 5.9239 (0.8); 5.9079 (0.6); 5 5.3018 (5.0); 5.2835 (2.0); 5.2584 (1.8); 5.1020 (1.9); 5.0596 (1.7); 3.9491 (16.0); 1.5825 (10.0); - 0.0002 (12.6) I.2-96: 1H-NMR (400 MHz, CDCl3): δ= 8.6331 (2.8); 8.6271 (3.3); 8.5872 (3.2); 8.5812 (2.4); 8.3740 (1.7); 8.3700 (2.6); 8.1900 (1.3); 8.1704 (1.5); 7.9800 (1.2); 7.9608 (1.4); 7.8813 (6.2); 7.8770 (6.3); 10 7.8071 (2.0); 7.8029 (3.0); 7.7986 (1.5); 7.6494 (1.3); 7.6300 (2.3); 7.6106 (1.1); 7.2623 (18.2); 7.2328 (1.0); 7.2123 (0.9); 5.1120 (1.0); 5.0914 (1.9); 5.0707 (1.0); 3.9537 (16.0); 2.1746 (0.8); 1.5733 (15.0); 1.2640 (1.5); 1.2220 (0.5); 1.2098 (0.9); 1.2015 (0.6); 1.1978 (0.6); 1.1891 (0.8); 0.8984 (0.7); 0.8818 (1.9); 0.8642 (0.8); 0.5284 (0.6); 0.5175 (0.7); 0.5081 (0.6); 0.5022 (0.6); 0.4109 (0.5); 0.3988 (0.6); 0.3903 (0.7); 0.3781 (0.8); 0.3609 (0.6); 0.3477 (0.7); 0.3378 (0.8); 0.3258 (0.9); 0.3134 (0.6); 0.0575 15 (0.7); 0.0454 (0.8); 0.0337 (0.8); 0.0205 (0.7); -0.0002 (20.8); -0.0084 (1.1) I.2-97: 1H-NMR (400 MHz, CDCl3): δ= 8.6337 (2.7); 8.6282 (3.3); 8.5868 (3.3); 8.5811 (2.6); 8.3698 (3.0); 8.1892 (1.6); 8.1697 (1.8); 8.0184 (3.3); 7.9845 (1.5); 7.9652 (1.7); 7.8391 (3.0); 7.7565 (3.1); 7.6487 (1.5); 7.6293 (2.6); 7.6099 (1.3); 7.2623 (16.0); 7.2379 (1.3); 7.2180 (1.2); 5.1035 (1.2); 5.0829 20 (2.3); 5.0622 (1.2); 3.9533 (16.0); 1.5770 (2.2); 1.2632 (1.9); 1.2300 (0.5); 1.2226 (0.6); 1.2096 (1.0); 1.1983 (0.8); 1.1893 (1.0); 1.1770 (0.6); 0.8978 (0.8); 0.8815 (1.9); 0.8641 (0.9); 0.5296 (0.7); 0.5180 (0.9); 0.5040 (0.8); 0.4104 (0.7); 0.3979 (0.7); 0.3898 (0.9); 0.3771 (1.0); 0.3663 (0.5); 0.3584 (0.9); 0.3471 (0.9); 0.3364 (1.0); 0.3240 (1.2); 0.3121 (0.8); 0.0548 (0.9); 0.0425 (1.0); 0.0304 (1.2); 0.0182 (1.0); -0.0002 (18.4) 25 I.2-98: 1H-NMR (400 MHz, CDCl3): δ= 8.6398 (2.8); 8.6339 (3.3); 8.5880 (3.2); 8.5820 (2.5); 8.3752 (2.7); 8.1924 (1.4); 8.1728 (1.5); 7.9845 (1.3); 7.9654 (1.5); 7.8782 (2.0); 7.8748 (3.0); 7.8713 (1.8); 7.6525 (1.3); 7.6329 (4.1); 7.6138 (1.3); 7.5306 (2.0); 7.2907 (0.9); 7.2630 (9.5); 5.3017 (6.3); 5.1268 (1.0); 5.1061 (2.0); 5.0855 (1.1); 3.9539 (16.0); 1.6072 (0.6); 1.2632 (1.3); 1.2269 (0.6); 1.2144 (0.9); 1.2026 (0.6); 1.1939 (0.9); 1.1815 (0.5); 0.8981 (0.6); 0.8817 (1.5); 0.8640 (0.7); 0.5345 (0.6); 0.5242 (0.8); 0.5093 (0.7); 0.4143 (0.5); 0.4073 (0.5); 0.4022 (0.6); 0.3940 (0.7); 0.3816 (0.9); 0.3711 (0.5); 0.3660 (0.6); 0.3613 (0.6); 0.3533 (0.8); 0.3434 (0.9); 0.3313 (1.0); 0.3183 (0.7); 0.0559 (0.7); 0.0437 (0.8); 0.0309 (0.8); 0.0195 (0.7); -0.0002 (11.1); -0.0084 (0.8) 35 BCS241005-Abroad STR 222 I.2-99: 1H-NMR (400 MHz, CDCl3): δ= 8.6388 (2.8); 8.6329 (3.2); 8.5872 (3.3); 8.5812 (2.6); 8.3755 (2.8); 8.1932 (1.5); 8.1736 (1.6); 7.9831 (1.4); 7.9639 (1.6); 7.7281 (3.0); 7.6532 (1.4); 7.6338 (2.5); 7.6144 (1.3); 7.5869 (2.3); 7.3804 (2.1); 7.2876 (1.1); 7.2632 (9.6); 5.3019 (2.1); 5.1350 (1.1); 5.1144 (2.2); 5.0938 (1.1); 3.9542 (16.0); 1.6272 (1.6); 1.2636 (0.6); 1.2251 (0.6); 1.2125 (1.0); 1.2002 (0.7); 1.1920 (0.9); 1.1798 (0.6); 0.8816 (0.7); 0.5319 (0.7); 0.5217 (0.8); 0.5067 (0.7); 0.4139 (0.6); 0.4013 (0.7); 0.3925 (0.9); 0.3805 (1.0); 0.3664 (0.7); 0.3535 (0.8); 0.3436 (1.0); 0.3311 (1.1); 0.3183 (0.8); 0.0566 (0.8); 0.0446 (0.9); 0.0317 (1.0); 0.0199 (0.8); -0.0002 (10.5) I.2-100: 1H-NMR(400 MHz, d6-DMSO): 10δ=8.7140 (0.6); 8.7080 (1.0); 8.6919 (1.1); 8.6858 (0.7); 8.1843 (0.8); 8.1793 (0.8); 8.1637 (0.7); 7.7849 (0.5); 7.6982 (1.2); 7.6780 (0.9); 3.8415 (4.0); 3.3326 (16.0); 2.5248 (0.8); 2.5112 (20.0); 2.5069 (38.7); 2.5025 (50.2); 2.4980 (37.4); 2.4938 (20.1); 0.0077 (1.3); -0.0002 (23.7); -0.0084 (2.0) I.2-105: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6401 (2.6); 8.6341 (3.2); 8.5947 (3.1); 8.5887 (2.4); 8.2960 (2.7); 8.1993 (1.4); 8.1796 (1.5); 7.9101 (1.2); 7.8907 (1.5); 7.6599 (1.3); 7.6405 (2.4); 7.6211 (1.1); 7.4354 (2.8); 7.3850 (2.0); 7.2828 (1.0); 7.2617 (24.8); 7.0213 (2.0); 5.6466 (0.9); 5.6280 (1.2); 5.6106 (0.9); 3.9443 (16.0); 1.9823 (0.6); 1.9739 (0.7); 1.9615 (1.2); 1.9491 (0.7); 1.9405 (0.6); 1.5621 (9.7); 1.4560 (6.3); 1.4393 (6.2); 1.0806 (0.7); 1.0683 (2.0); 1.0639 (2.0); 1.0474 (2.1); 1.0429 (1.8); 1.0314 (0.8); 0.7795 (0.9); 0.7675 (2.7); 0.7635 (2.2); 0.7554 (2.1); 0.7511 (2.5); 0.7387 (0.7); -0.0002 (29.9); - 0.0084 (1.4) I.2-106: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6620 (7.4); 8.6559 (8.9); 8.6119 (8.5); 8.6059 (6.8); 8.3657 (7.1); 8.2415 (3.7); 8.2218 (4.0); 7.9751 (3.3); 7.9556 (3.9); 7.6959 (3.4); 7.6764 (6.1); 7.6568 (2.9); 7.5190 (0.8); 7.4471 (7.6); 7.3953 (5.6); 7.3780 (3.3); 7.3576 (3.1); 7.2604 (116.1); 7.0171 (5.2); 5.6813 (2.2); 5.6648 (3.0); 5.6456 (2.3); 5.6297 (0.7); 3.7681 (1.1); 3.7518 (2.3); 2.1236 (0.9); 1.9838 (0.9); 1.9715 (1.7); 1.9630 (1.9); 1.9504 (3.3); 1.9379 (2.1); 1.9294 (2.0); 1.9163 (1.1); 1.8721 (1.3); 1.8559 (2.9); 1.8393 (1.3); 1.4840 (15.8); 1.4672 (16.0); 1.4322 (2.6); 1.2425 (0.9); 1.0651 (2.0); 1.0528 (5.2); 1.0484 (5.5); 1.0320 (5.8); 1.0274 (5.2); 1.0158 (2.5); 0.7716 (2.2); 0.7595 (7.0); 0.7556 (5.7); 0.7470 (5.8); 0.7430 (7.0); 0.7309 (2.1); 0.1464 (0.6); -0.0002 (142.2); -0.0083 (8.4); -0.1491 (0.8) I.2-107: 1H-NMR(300.0 MHz, d6-DMSO): δ= 12.7329 (1.8); 9.1049 (1.7); 9.0831 (1.8); 8.6133 (13.7); 8.1010 (3.6); 8.0946 (3.7); 7.9571 (3.4); 7.9494 (3.9); 7.8860 (1.8); 7.8782 (1.5); 7.8573 (2.0); 7.8496 (1.7); 7.8163 (1.4); 7.8097 (1.3); 7.7882 (2.5); 7.7816 (2.5); 7.7247 (4.5); 7.6967 (2.4); 7.2909 (2.9); 7.2619 (2.6); 5.3648 (1.0); 5.3424 (1.6); 5.3198 (1.1); 3.8950 (16.0); 3.8583 (0.7); 3.3327 (8.2); 2.5048 (9.8); 2.0775 (8.5); 1.4653 (6.0); 1.4424 (5.8); -0.0002 (3.1) BCS241005-Abroad STR 223 I.2-108: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.0855 (1.4); 9.0636 (1.5); 8.6300 (1.5); 8.6217 (6.5); 8.6185 (6.4); 8.6101 (1.6); 8.0856 (3.1); 8.0792 (3.2); 7.9424 (2.5); 7.9350 (3.7); 7.9190 (1.8); 7.9108 (1.0); 7.8905 (1.8); 7.8826 (1.3); 7.8060 (1.2); 7.7993 (1.0); 7.7781 (2.2); 7.7715 (2.2); 7.7257 (3.9); 7.6977 (2.0); 7.3118 (2.4); 7.2831 (2.3); 5.3497 (0.9); 5.3271 (1.4); 5.3045 (0.9); 3.8947 (14.7); 3.8608 (0.8); 3.8157 (0.8); 3.7996 (0.4); 3.7666 (16.0); 3.3182 (21.0); 3.2948 (0.7); 2.5077 (25.0); 2.5019 (33.4); 2.4961 (24.1); 1.4673 (5.3); 1.4444 (5.2); -0.0002 (13.8) I.2-109: 1H-NMR(300.0 MHz, d6-DMSO): δ= 12.7407 (3.8); 9.2148 (1.5); 9.1930 (1.5); 8.6185 (16.0); 7.9972 (2.2); 7.9918 (4.0); 7.9865 (2.3); 7.9485 (3.3); 7.9407 (3.9); 7.8788 (1.7); 7.8709 (1.4); 7.8502 (1.9); 7.8422 (1.6); 7.7595 (4.7); 7.7567 (6.0); 7.7546 (5.7); 7.2880 (2.8); 7.2589 (2.6); 5.3741 (0.9); 5.3517 (1.4); 5.3292 (1.0); 3.8905 (15.8); 3.3230 (30.0); 2.5136 (14.0); 2.5077 (24.7); 2.5023 (31.4); 2.4971 (20.0); 1.4766 (5.4); 1.4537 (5.3); 0.0108 (0.6); -0.0002 (16.2); -0.0112 (0.5) I.2-110: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.1967 (1.4); 9.1746 (1.5); 8.6387 (1.3); 8.6299 (7.3); 8.6281 (7.3); 8.6194 (1.4); 7.9823 (2.0); 7.9776 (3.2); 7.9726 (2.1); 7.9366 (2.4); 7.9291 (3.7); 7.9138 (1.9); 7.9060 (1.0); 7.8853 (1.7); 7.8775 (1.3); 7.7507 (3.9); 7.3097 (2.5); 7.2810 (2.3); 5.3642 (0.9); 5.3418 (1.4); 5.3192 (0.9); 3.8912 (14.7); 3.7626 (16.0); 3.3183 (6.6); 2.5082 (18.0); 2.5023 (23.9); 2.4965 (17.1); 2.0752 (0.6); 1.4826 (5.2); 1.4598 (5.2); 0.0105 (0.4); -0.0001 (9.8); -0.0110 (0.4) I.2-111: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6377 (1.5); 8.6318 (1.9); 8.5942 (1.8); 8.5883 (1.4); 8.3154 (1.5); 8.1992 (0.8); 8.1794 (0.9); 7.9334 (0.7); 7.9145 (0.8); 7.8729 (3.6); 7.8687 (3.7); 7.8069 (1.2); 7.8028 (1.7); 7.7984 (0.9); 7.6644 (0.8); 7.6450 (1.4); 7.6258 (0.7); 7.2618 (25.6); 7.1585 (0.5); 7.1365 (0.6); 5.5713 (0.5); 5.5544 (0.6); 5.3021 (3.8); 3.9523 (9.4); 1.8404 (0.5); 1.7680 (0.6); 1.7502 (0.5); 1.5568 (16.0); 0.7830 (1.8); 0.7644 (3.7); 0.7459 (1.7); -0.0002 (28.2); -0.0082 (1.5) I.2-112: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6422 (2.8); 8.6363 (3.2); 8.5936 (3.3); 8.5877 (2.5); 8.3192 (2.9); 8.2017 (1.6); 8.1821 (1.6); 7.9361 (1.4); 7.9170 (1.6); 7.8636 (3.1); 7.6672 (1.5); 7.6478 (2.6); 7.6277 (3.0); 7.5298 (2.2); 7.2632 (8.2); 7.2149 (1.1); 7.1942 (1.1); 5.6050 (0.6); 5.5865 (1.1); 5.5698 (1.1); 5.5504 (0.5); 5.3018 (5.9); 3.9526 (16.0); 1.8647 (0.6); 1.8469 (1.0); 1.8289 (0.9); 1.8123 (0.8); 1.7922 (0.9); 1.7735 (1.2); 1.7555 (1.0); 1.7386 (0.7); 1.6043 (8.2); 0.7889 (3.4); 0.7704 (6.8); 0.7519 (3.0); -0.0002 (9.2) I.2-113: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6419 (2.3); 8.6364 (2.5); 8.5938 (2.7); 8.5881 (2.1); 8.3193 (2.8); 8.2018 (1.6); 8.1821 (1.6); 7.9362 (1.4); 7.9170 (1.6); 7.8636 (3.1); 7.6672 (1.5); BCS241005-International STR 224 7.6478 (2.6); 7.6278 (3.0); 7.5299 (2.2); 7.2632 (8.3); 7.2148 (1.1); 7.1935 (1.1); 5.6048 (0.6); 5.5863 (1.1); 5.5698 (1.1); 5.5506 (0.5); 5.3018 (6.0); 3.9526 (16.0); 1.8649 (0.6); 1.8470 (1.0); 1.8290 (0.9); 1.8121 (0.8); 1.7924 (0.9); 1.7736 (1.2); 1.7556 (1.0); 1.7386 (0.7); 1.6031 (8.1); 0.7889 (3.5); 0.7704 (6.8); 0.7520 (3.0); -0.0002 (9.4) I.2-114: 1H-NMR(400.2 MHz, d6-DMSO): δ= 9.0105 (2.2); 8.9929 (2.5); 8.7797 (6.8); 8.7735 (8.2); 8.7190 (4.6); 8.7133 (4.7); 7.9827 (7.0); 7.9778 (8.9); 7.9561 (2.9); 7.9354 (2.7); 7.9309 (2.2); 7.8165 (4.5); 7.7609 (3.5); 7.7408 (7.7); 7.6480 (1.0); 7.6275 (1.0); 7.5998 (3.8); 5.1838 (0.4); 5.0935 (1.3); 5.0761 (1.9); 5.0590 (1.2); 5.0414 (0.3); 3.8761 (0.3); 3.8475 (2.9); 3.7182 (16.0); 3.5082 (1.0); 3.3229 (46.2); 2.6756 (0.3); 2.6713 (0.4); 2.6667 (0.4); 2.5111 (23.5); 2.5067 (48.0); 2.5022 (65.3); 2.4977 (47.4); 2.4933 (22.5); 2.3291 (0.4); 1.4853 (16.0); 1.4682 (15.5); 1.2327 (0.3); 0.0079 (1.3); -0.0002 (29.1); -0.0084 (1.2) I.2-115: 1H-NMR(300.1 MHz, d6-DMSO): δ= 13.1836 (2.2); 9.0486 (2.6); 9.0267 (3.2); 8.7651 (7.5); 8.7576 (9.1); 8.7083 (10.9); 8.7003 (9.1); 8.0417 (4.8); 7.9779 (5.7); 7.9729 (5.9); 7.9507 (6.3); 7.9442 (5.5); 7.8564 (9.3); 7.7421 (3.8); 7.7191 (9.1); 7.6428 (6.4); 7.6070 (1.0); 5.1853 (0.6); 5.0612 (1.5); 5.0386 (2.1); 5.0160 (1.5); 3.5105 (0.7); 3.3207 (7.0); 2.5037 (38.8); 1.4763 (16.0); 1.4536 (15.9); 1.2362 (0.3); -0.0002 (43.0) I.2-116: 1H-NMR(400.2 MHz, d6-DMSO): δ= 9.0678 (3.5); 8.7143 (12.7); 8.7086 (15.6); 8.6710 (10.6); 7.9122 (16.0); 7.7562 (15.5); 7.6886 (11.7); 7.6420 (0.4); 7.5388 (0.3); 7.4811 (12.4); 7.4610 (11.3); 6.5306 (0.5); 4.9721 (3.0); 3.8060 (3.5); 3.7430 (3.1); 3.5085 (1.5); 3.3244 (76.6); 3.3022 (3.0); 2.6762 (1.0); 2.6718 (1.4); 2.6674 (1.0); 2.5115 (69.4); 2.5072 (144.3); 2.5027 (198.3); 2.4982 (147.3); 2.4939 (73.8); 2.4264 (0.3); 2.3340 (1.0); 2.3295 (1.4); 2.3248 (1.1); 2.1503 (7.9); 1.4188 (11.4); 1.2337 (0.5); 0.1462 (0.4); 0.0079 (4.0); -0.0002 (93.4); -0.0083 (4.3); -0.1492 (0.4) I.2-117: 1H-NMR(400.2 MHz, d6-DMSO): δ= 8.9602 (1.8); 8.7052 (7.5); 8.6992 (9.0); 8.6614 (5.8); 8.1351 (0.3); 8.0183 (4.2); 7.9047 (2.6); 7.7696 (0.7); 7.7472 (2.2); 7.7257 (6.4); 7.7223 (6.6); 7.7105 (16.0); 7.6896 (4.2); 7.4907 (8.1); 7.4706 (7.2); 4.9513 (1.5); 3.8040 (2.0); 3.5079 (0.4); 3.3249 (18.1); 5 3.3019 (1.2); 2.6763 (0.4); 2.6715 (0.5); 2.6669 (0.4); 2.5115 (26.6); 2.5071 (54.8); 2.5025 (74.8); 2.4980 (55.0); 2.4936 (26.9); 2.3339 (0.5); 2.3294 (0.6); 2.3249 (0.5); 2.1557 (3.3); 2.0759 (1.2); 1.5204 (0.3); 1.5024 (0.4); 1.4064 (6.0); 0.0080 (1.7); -0.0002 (40.6); -0.0084 (1.9) I.2-118:1H-NMR(300.1 MHz, d6-DMSO): BCS241005-Abroad STR 225 δ= 12.8877 (2.9); 8.9865 (3.5); 8.9658 (3.4); 8.6901 (10.5); 8.6820 (14.6); 8.6522 (11.9); 8.6443 (8.5); 8.0895 (0.4); 8.0418 (10.7); 8.0369 (10.5); 7.9641 (0.7); 7.9228 (5.4); 7.8968 (5.9); 7.8512 (0.9); 7.8205 (0.9); 7.7697 (4.4); 7.7635 (3.9); 7.7417 (10.1); 7.7356 (9.7); 7.7079 (16.0); 7.6801 (6.0); 7.4745 (9.0); 7.4474 (7.8); 6.5217 (0.6); 4.9512 (2.1); 3.3173 (210.0); 2.7272 (1.1); 2.7211 (0.8); 2.5861 (0.4); 2.5070 (132.3); 2.5012 (174.5); 2.4954 (124.4); 2.2761 (1.0); 2.2715 (1.2); 2.2657 (1.1); 2.1563 (7.6); 2.0738 (10.9); 1.4007 (7.4); 1.2659 (0.4); 1.2365 (0.6); 0.1948 (0.4); 0.0103 (2.9); -0.0001 (65.9); -0.1989 (0.4) I.2-119: 1H-NMR(300.1 MHz, d6-DMSO):δ= 13.7184 (0.4); 12.9695 (0.6); 12.8889 (2.1); 12.7378 (0.4); 10.0331 (0.4); 9.0939 (3.4); 9.0718 (3.3); 8.6980 (10.9); 8.6899 (16.0); 8.6612 (12.8); 8.6530 (8.9); 8.1375 (0.4); 8.0133 (0.5); 7.9660 (0.7); 7.9318 (13.2); 7.8918 (6.5); 7.8275 (1.0); 7.7919 (0.9); 7.7458 (10.1); 7.7074 (10.2); 7.6642 (0.4); 7.4966 (0.4); 7.4635 (8.1); 7.4361 (7.2); 6.5205 (1.1); 5.0855 (0.4); 4.9723 (2.2); 4.9545 (2.0); 3.6611 (0.4); 3.3819 (0.4); 3.3179 (281.0); 2.7273 (1.7); 2.7215 (1.3); 2.5973 (0.6); 2.5686 (0.7); 2.5072 (224.0); 2.5015 (291.7); 2.4959 (206.7); 2.2720 (2.0); 2.1507 (8.7); 1.5879 (0.4); 1.4134 (7.1); 1.2402 (0.6); 1.1535 (0.4); 0.1951 (0.5); 0.0103 (4.4); -0.0001 (93.6); -0.0110 (3.3); - 0.1972 (0.6) I.2-120: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6362 (2.6); 8.6303 (3.2); 8.5950 (3.2); 8.5891 (2.4); 8.2478 (1.3); 8.2418 (1.3); 8.2309 (1.3); 8.2250 (1.3); 7.9086 (0.7); 7.9026 (0.8); 7.8976 (0.8); 7.8914 (0.8); 7.8873 (0.8); 7.8813 (0.9); 7.8764 (0.8); 7.8704 (0.7); 7.7040 (1.8); 7.7003 (2.8); 7.6964 (1.7); 7.5586 (2.0); 7.3748 (1.9); 7.3628 (1.4); 7.3412 (1.5); 7.3371 (1.4); 7.3156 (1.2); 7.2831 (0.9); 7.2614 (12.4); 5.6251 (0.9); 5.6078 (1.1); 5.5892 (0.9); 3.9616 (16.0); 1.5746 (9.0); 1.4663 (6.3); 1.4496 (6.3); -0.0002 (13.2) I.2-122: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6377 (1.9); 8.6317 (2.1); 8.5731 (2.0); 8.5671 (1.7); 8.1932 (1.7); 8.1883 (1.6); 7.8522 (1.3); 7.8484 (2.0); 7.8447 (1.1); 7.7232 (0.9); 7.7182 (0.8); 7.7035 (1.0); 7.6986 (0.9); 7.6071 (1.3); 7.5215 (1.2); 7.4484 (1.3); 7.4288 (1.1); 7.3468 (0.6); 7.3271 (0.6); 7.2608 (15.9); 5.6715 (0.6); 5.6540 (0.7); 5.6352 (0.6); 3.9033 (11.0); 2.7051 (7.7); 1.5575 (16.0); 1.4531 (4.1); 1.4365 (4.1); 1.2649 (0.5); 0.8820 (0.6); -0.0002 (18.0); -0.0084 (1.0) I.2-123: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6323 (2.7); 8.6263 (3.0); 8.5559 (3.0); 8.5498 (2.4); 8.1965 (2.4); 8.1917 (2.2); 7.8075 (2.0); 7.7320 (1.3); 7.7271 (1.2); 7.7124 (1.5); 7.7075 (1.3); 7.6743 (1.3); 7.6694 (1.1); 7.6535 (1.8); 7.6486 (1.6); 7.5603 (2.9); 7.5395 (2.1); 7.4479 (1.8); 7.4283 (1.6); 7.3800 (0.8); 7.3607 (0.8); 7.2619 (9.4); 5.6834 (0.8); 5.6660 (1.1); 5.6475 (0.8); 5.2997 (8.8); 3.9011 (16.0); 2.7034 (11.3); 1.5892 (11.0); 1.4534 (6.0); 1.4367 (6.0); 1.2613 (0.6); 0.8818 (0.7); -0.0002 (10.6); -0.0081 (0.6) BCS241005-Ausland STR 226 I.2-124: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6239 (2.0); 8.6180 (2.3); 8.5670 (2.3); 8.5611 (1.8); 8.2006 (1.9); 8.1958 (1.8); 7.7493 (1.0); 7.7444 (0.9); 7.7297 (1.1); 7.7248 (1.0); 7.5253 (1.8); 7.4469 (2.2); 7.4263 (1.3); 7.3055 (0.7); 7.2863 (0.8); 7.2607 (16.4); 7.1678 (1.4); 5.6857 (0.7); 5.6683 (0.8); 5.6500 (0.6); 3.8974 (11.8); 2.7028 (8.8); 2.4326 (8.2); 1.5578 (16.0); 1.4560 (4.7); 1.4394 (4.6); -0.0002 (18.5); -0.0082 (1.0) I.2-125: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6381 (1.0); 8.6321 (1.2); 8.5726 (1.2); 8.5665 (1.0); 8.1938 (1.0); 8.1888 (0.9); 7.7229 (0.5); 7.7025 (1.6); 7.6983 (1.2); 7.5646 (0.7); 7.4489 (0.7); 7.4290 (0.6); 7.3716 (0.8); 7.2606 (15.7); 3.9035 (6.3); 2.7054 (4.4); 1.5501 (16.0); 1.4529 (2.4); 1.4363 (2.4); -0.0002 (17.9); -0.0081 (1.0) I.2-126: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6342 (2.6); 8.6283 (3.2); 8.5909 (3.2); 8.5850 (2.4); 8.3137 (2.6); 8.1970 (1.4); 8.1772 (1.5); 8.0071 (3.1); 7.9334 (1.2); 7.9143 (1.5); 7.8427 (1.8); 7.8385 (2.7); 7.8345 (1.7); 7.7492 (2.0); 7.7449 (2.8); 7.6612 (1.3); 7.6423 (2.3); 7.6230 (1.1); 7.2605 (27.0); 7.1397 (0.9); 7.1196 (1.0); 5.5673 (1.0); 5.5499 (1.0); 5.5309 (0.5); 3.9509 (16.0); 1.8570 (0.6); 1.8388 (0.9); 1.8225 (0.8); 1.8044 (0.8); 1.7869 (0.9); 1.7683 (1.1); 1.7501 (0.9); 1.7333 (0.6); 1.5530 (7.0); 0.7830 (3.2); 0.7644 (6.4); 0.7459 (2.9); -0.0002 (33.1); -0.0084 (1.4) I.2-127: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6335 (2.7); 8.6278 (3.3); 8.5907 (3.3); 8.5849 (2.5); 8.3134 (2.9); 8.1966 (1.6); 8.1768 (1.7); 8.0069 (3.3); 7.9330 (1.5); 7.9140 (1.7); 7.8383 (2.9); 7.7445 (3.0); 7.6610 (1.5); 7.6418 (2.6); 7.6223 (1.3); 7.2606 (22.0); 7.1374 (1.1); 7.1166 (1.1); 5.5852 (0.6); 5.5671 (1.1); 5.5498 (1.1); 5.5307 (0.6); 3.9508 (16.0); 1.8563 (0.7); 1.8381 (1.0); 1.8201 (1.0); 1.8037 (0.9); 1.7861 (1.0); 1.7675 (1.2); 1.7494 (1.1); 1.7321 (0.7); 1.5547 (11.7); 0.7823 (3.5); 0.7639 (7.0); 0.7455 (3.2); -0.0002 (27.0); -0.0082 (1.6) I.2-128: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6265 (2.0); 8.6205 (2.4); 8.5728 (2.4); 8.5668 (1.8); 8.3731 (2.0); 8.1868 (1.0); 8.1675 (1.1); 7.9899 (0.9); 7.9705 (1.0); 7.9241 (2.1); 7.9191 (2.1); 7.6672 (1.0); 7.6620 (0.9); 7.6468 (2.2); 7.6414 (1.4); 7.6281 (1.8); 7.6087 (0.9); 7.5383 (2.3); 7.5176 (1.8); 7.2604 (33.0); 7.2325 (1.0); 5.1449 (0.8); 5.1244 (1.5); 5.1038 (0.8); 3.9508 (12.2); 2.0076 (2.8); 1.5478 (16.0); 1.2039 (0.7); 1.1832 (0.6); 0.5080 (0.6); 0.3840 (0.6); 0.3725 (0.7); 0.3610 (0.6); 0.3524 (0.6); 0.3375 (0.7); 0.3256 (0.7); 0.0609 (0.5); 0.0491 (0.6); 0.0372 (0.6); 0.0245 (0.6); -0.0002 (39.9); -0.0083 (2.0) I.2-129: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6272 (2.7); 8.6212 (3.2); 8.5730 (3.1); 8.5670 (2.5); 8.3731 (2.7); 8.1873 (1.4); 8.1674 (1.6); 7.9907 (1.2); 7.9709 (1.5); 7.9244 (2.9); 7.9192 (2.8); 7.6677 (1.3); 7.6622 (1.2); 7.6469 (3.0); 7.6414 (1.8); 7.6279 (2.4); 7.6083 (1.2); 7.5380 (3.0); 7.5173 (2.5); 7.2602 (76.0); 5.1440 (1.1); 5.1237 (2.1); 5.1031 (1.1); 3.9507 (16.0); 2.0078 (2.1); 1.5437 (14.7); 1.2038 (0.9); BCS241005-Abroad STR 227 1.1836 (0.9); 0.5089 (0.8); 0.3938 (0.8); 0.3832 (0.8); 0.3724 (1.0); 0.3519 (0.9); 0.3374 (0.9); 0.3249 (1.0); 0.3123 (0.7); 0.0608 (1.0); 0.0496 (1.0); 0.0352 (1.2); -0.0002 (94.0) I.2-130: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6269 (1.7); 8.6209 (2.0); 8.5885 (2.0); 8.5827 (1.4); 8.3425 (1.7); 8.1947 (0.9); 8.1752 (1.0); 8.0276 (1.9); 7.9763 (0.9); 7.9569 (0.9); 7.8481 (1.7); 7.7623 (1.8); 7.6701 (0.8); 7.6507 (1.5); 7.6312 (0.7); 7.2608 (18.6); 7.0983 (0.6); 7.0764 (0.6); 5.5246 (0.7); 5.5054 (0.9); 5.4829 (0.7); 3.9567 (9.6); 2.0078 (2.0); 1.9963 (0.6); 1.5559 (16.0); 0.8850 (4.0); 0.8681 (3.8); 0.6384 (3.8); 0.6215 (3.7); -0.0002 (18.0); -0.0082 (1.0) I.2-131: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6272 (1.5); 8.6212 (1.9); 8.5886 (1.8); 8.5827 (1.3); 8.3424 (1.5); 8.1946 (0.8); 8.1751 (0.8); 8.0313 (1.1); 8.0276 (1.8); 8.0240 (1.0); 7.9763 (0.7); 7.9569 (0.8); 7.8524 (1.0); 7.8482 (1.6); 7.8442 (0.9); 7.7667 (1.1); 7.7624 (1.6); 7.7583 (0.9); 7.6702 (0.7); 7.6509 (1.3); 7.6314 (0.6); 7.2607 (27.4); 7.0997 (0.5); 7.0765 (0.5); 5.5247 (0.6); 5.5052 (0.7); 5.4830 (0.6); 3.9568 (9.2); 2.0078 (2.0); 1.9966 (0.6); 1.5526 (16.0); 0.8852 (3.5); 0.8683 (3.4); 0.6385 (3.3); 0.6216 (3.2); -0.0002 (26.1); -0.0083 (1.5) I.2-132: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6747 (2.5); 8.6687 (3.1); 8.6320 (3.1); 8.6261 (2.4); 8.3107 (2.5); 8.2032 (1.3); 8.1833 (1.4); 7.9926 (1.8); 7.9891 (3.0); 7.9855 (1.7); 7.8777 (1.2); 7.8587 (1.4); 7.8383 (1.8); 7.8341 (2.7); 7.8301 (1.6); 7.7324 (1.9); 7.7284 (2.7); 7.7243 (1.5); 7.6488 (1.3); 7.6295 (2.2); 7.6102 (1.1); 7.4047 (0.9); 7.3848 (0.9); 7.2603 (35.2); 6.0538 (0.6); 6.0363 (1.3); 6.0177 (1.0); 5.9901 (0.8); 5.9650 (0.8); 5.9485 (1.2); 5.9321 (0.6); 5.9226 (0.8); 5.9068 (0.6); 5.2762 (1.8); 5.2509 (1.7); 5.0961 (1.7); 5.0537 (1.6); 3.9474 (16.0); 1.5462 (15.6); -0.0002 (43.0); -0.0082 (2.6) I.2-133: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6747 (1.0); 8.6687 (1.2); 8.6322 (1.1); 8.6261 (0.9); 8.3105 (0.9); 8.1836 (0.5); 7.9927 (0.7); 7.9892 (1.1); 7.9855 (0.6); 7.8386 (0.6); 7.8346 (1.0); 7.8304 (0.6); 7.7325 (0.7); 7.7284 (1.0); 7.7243 (0.6); 7.6296 (0.8); 7.2601 (31.1); 5.2765 (0.6); 5.2510 (0.6); 5.0961 (0.6); 5.0534 (0.5); 3.9474 (6.0); 1.5403 (16.0); -0.0002 (38.4); -0.0083 (2.1) I.2-134: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6354 (1.6); 8.6296 (1.9); 8.5841 (1.8); 8.5782 (1.5); 8.3727 (1.6); 8.1911 (0.8); 8.1715 (0.9); 7.9787 (0.8); 7.9594 (0.9); 7.7249 (1.7); 7.6509 (0.8); 7.6314 (1.4); 7.6121 (0.7); 7.5835 (1.2); 7.3784 (1.2); 7.2607 (16.0); 5.1385 (0.6); 5.1179 (1.2); 5.0973 (0.6); 3.9531 (9.2); 1.5574 (16.0); 1.2119 (0.5); 1.1914 (0.5); 0.3802 (0.5); 0.3429 (0.5); 0.3306 (0.6); 0.0474 (0.5); 0.0351 (0.6); -0.0002 (15.0); -0.0083 (0.9) I.2-135: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6353 (1.0); 8.6294 (1.2); 8.5840 (1.2); 8.5782 (1.0); 8.3725 (1.1); 8.1905 (0.6); 8.1714 (0.7); 7.9778 (0.6); 7.9591 (0.6); 7.7246 (1.2); 7.6504 (0.6); 7.6312 (1.0); BCS241005-Abroad STR 228 7.6120 (0.5); 7.5841 (0.9); 7.3785 (0.9); 7.2606 (15.6); 5.1174 (0.9); 3.9531 (6.3); 1.5518 (16.0); 0.0456 (0.5); 0.0350 (0.6); 0.0225 (0.6); -0.0002 (15.0) I.2-136: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6306 (2.0); 8.6248 (2.4); 8.5791 (2.4); 8.5732 (1.9); 8.3173 (2.1); 8.1955 (1.1); 8.1759 (1.2); 7.9420 (1.0); 7.9181 (2.8); 7.9131 (2.2); 7.6616 (2.0); 7.6568 (1.0); 7.6417 (3.0); 7.6358 (1.4); 7.6230 (1.0); 7.5374 (2.4); 7.5166 (1.7); 7.2604 (26.5); 7.1889 (0.8); 7.1682 (0.8); 5.5883 (0.8); 5.5714 (0.8); 3.9492 (12.4); 1.8404 (0.7); 1.8236 (0.6); 1.8063 (0.5); 1.7811 (0.6); 1.7627 (0.9); 1.7447 (0.7); 1.7282 (0.5); 1.5496 (16.0); 0.7828 (2.5); 0.7644 (5.1); 0.7459 (2.4); -0.0002 (32.3); -0.0080 (2.0) I.2-137: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6307 (2.3); 8.6248 (2.8); 8.5791 (2.7); 8.5732 (2.2); 8.3174 (2.3); 8.1958 (1.2); 8.1759 (1.3); 7.9421 (1.1); 7.9184 (3.1); 7.9131 (2.6); 7.6618 (2.2); 7.6567 (1.2); 7.6418 (3.2); 7.6358 (1.6); 7.6232 (1.0); 7.5374 (2.7); 7.5168 (2.0); 7.2605 (29.6); 7.1901 (0.8); 7.1695 (0.8); 5.5886 (0.8); 5.5714 (0.8); 3.9492 (14.2); 1.8405 (0.8); 1.8224 (0.7); 1.8064 (0.6); 1.7816 (0.6); 1.7631 (1.0); 1.7451 (0.8); 1.7281 (0.6); 1.5503 (16.0); 0.7830 (2.7); 0.7645 (5.7); 0.7459 (2.6); -0.0002 (36.2); -0.0084 (2.1) I.2-138: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6720 (1.6); 8.6660 (1.9); 8.6205 (1.9); 8.6147 (1.5); 8.3142 (1.6); 8.2014 (0.8); 8.1817 (1.0); 7.9000 (1.7); 7.8947 (1.6); 7.8827 (0.9); 7.8632 (1.0); 7.6469 (1.5); 7.6415 (0.8); 7.6269 (1.9); 7.6202 (1.2); 7.6094 (0.7); 7.5284 (1.8); 7.5077 (1.4); 7.4563 (0.6); 7.4368 (0.6); 7.2600 (40.2); 6.0538 (0.9); 6.0355 (0.6); 5.9923 (0.5); 5.9670 (0.5); 5.9501 (0.7); 5.2703 (1.1); 5.2444 (1.0); 5.0931 (1.1); 5.0500 (1.0); 3.9457 (9.6); 2.1717 (0.9); 1.5401 (16.0); -0.0002 (51.0) I.2-139: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6723 (2.5); 8.6663 (3.0); 8.6206 (2.9); 8.6145 (2.3); 8.3143 (2.4); 8.3104 (1.4); 8.2014 (1.3); 8.1817 (1.4); 7.9000 (2.7); 7.8950 (2.6); 7.8832 (1.2); 7.8638 (1.4); 7.6470 (2.2); 7.6414 (1.3); 7.6276 (2.8); 7.6207 (1.8); 7.6091 (1.1); 7.5284 (2.9); 7.5076 (2.1); 7.4579 (0.8); 7.4385 (0.8); 7.2603 (34.1); 6.0711 (0.6); 6.0549 (1.1); 6.0354 (0.9); 5.9922 (0.7); 5.9669 (0.8); 5.9504 (1.1); 5.9338 (0.6); 5.9245 (0.8); 5.9085 (0.6); 5.2701 (1.7); 5.2448 (1.6); 5.0928 (1.6); 5.0503 (1.5); 3.9457 (16.0); 2.0074 (1.0); 1.5463 (10.8); -0.0002 (42.6); -0.0084 (2.4) I.2-140: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6753 (2.5); 8.6695 (3.0); 8.6320 (3.0); 8.6260 (2.4); 8.3108 (2.7); 8.2031 (1.5); 8.1840 (1.6); 7.8768 (1.5); 7.8536 (6.5); 7.8499 (6.2); 7.7970 (2.7); 7.6489 (1.4); 7.6296 (2.4); 7.6106 (1.1); 7.4183 (1.0); 7.3995 (1.1); 7.2601 (27.5); 6.0547 (0.7); 6.0370 (1.4); 6.0183 (1.1); 5.9890 (0.7); 5.9640 (0.8); 5.9476 (1.2); 5.9310 (0.6); 5.9213 (0.8); 5.9057 (0.6); 5.2757 (2.0); 5.2509 (1.8); 5.0966 (1.9); 5.0539 (1.7); 3.9475 (14.8); 1.5469 (16.0); -0.0002 (34.1) BCS241005-Ausland STR 229 I.2-141: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6758 (2.5); 8.6698 (3.1); 8.6321 (3.0); 8.6261 (2.3); 8.3110 (2.4); 8.2034 (1.3); 8.1837 (1.4); 7.8772 (1.2); 7.8540 (6.5); 7.8497 (6.3); 7.8007 (2.0); 7.7965 (2.8); 7.7923 (1.4); 7.6491 (1.3); 7.6297 (2.2); 7.6104 (1.1); 7.4228 (0.8); 7.4028 (0.9); 7.2606 (20.6); 6.0543 (0.6); 6.0377 (1.2); 6.0187 (0.9); 5.9895 (0.8); 5.9645 (0.8); 5.9477 (1.2); 5.9314 (0.6); 5.9220 (0.8); 5.9060 (0.6); 5.2763 (1.8); 5.2511 (1.6); 5.0971 (1.7); 5.0545 (1.6); 3.9476 (16.0); 1.5536 (4.7); -0.0002 (25.2); -0.0083 (1.4) I.2-142: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6321 (0.7); 8.6261 (0.9); 8.5881 (0.9); 8.5823 (0.7); 8.3460 (0.7); 7.8760 (0.8); 7.6543 (0.7); 7.6423 (0.6); 7.5381 (0.5); 7.2605 (16.7); 3.9572 (4.4); 1.5485 (16.0); 0.8852 (1.7); 0.8683 (1.7); 0.6488 (1.6); 0.6319 (1.6); -0.0002 (16.1); -0.0084 (0.9) I.2-143: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6321 (2.2); 8.6262 (2.6); 8.5882 (2.6); 8.5823 (2.0); 8.3466 (2.2); 8.1981 (1.2); 8.1784 (1.3); 7.9767 (1.0); 7.9572 (1.2); 7.8764 (2.5); 7.6740 (1.1); 7.6546 (2.1); 7.6428 (1.8); 7.5383 (1.6); 7.2610 (17.1); 7.1561 (0.8); 7.1335 (0.8); 5.5483 (0.8); 5.5293 (1.1); 5.5070 (0.9); 3.9573 (12.9); 2.0175 (0.8); 2.0075 (1.2); 2.0004 (0.8); 1.9831 (0.5); 1.5630 (16.0); 0.8855 (5.2); 0.8687 (5.0); 0.6489 (4.9); 0.6320 (4.8); -0.0002 (16.3); -0.0083 (1.0) I.2-144: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6857 (2.4); 8.6798 (2.8); 8.6357 (2.9); 8.6298 (2.3); 8.3156 (2.6); 8.2069 (1.4); 8.1873 (1.5); 7.8816 (1.2); 7.8621 (1.6); 7.8524 (2.0); 7.8488 (3.0); 7.6537 (1.3); 7.6343 (2.3); 7.6141 (1.9); 7.6074 (2.2); 7.5243 (2.0); 7.4996 (1.0); 7.4802 (1.0); 7.2628 (9.6); 6.0655 (0.7); 6.0486 (1.3); 6.0297 (1.0); 5.9950 (0.8); 5.9700 (0.8); 5.9532 (1.2); 5.9367 (0.6); 5.9275 (0.8); 5.9114 (0.6); 5.3017 (3.4); 5.2861 (1.9); 5.2609 (1.8); 5.1030 (1.8); 5.0607 (1.6); 3.9490 (16.0); 1.5931 (0.7); -0.0002 (10.8); -0.0083 (0.6) I.2-145: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6843 (1.5); 8.6784 (1.7); 8.6363 (1.9); 8.6307 (1.5); 8.3148 (2.0); 8.2071 (1.1); 8.1874 (1.2); 7.8796 (0.9); 7.8604 (1.2); 7.8502 (1.6); 7.8466 (2.4); 7.8428 (1.4); 7.6538 (1.0); 7.6344 (1.8); 7.6147 (1.1); 7.6055 (1.6); 7.5252 (1.5); 7.4811 (0.7); 7.4618 (0.8); 7.2619 (25.0); 6.0475 (1.0); 6.0286 (0.7); 5.9928 (0.6); 5.9678 (0.6); 5.9509 (0.9); 5.9344 (0.5); 5.9251 (0.6); 5.3021 (3.8); 5.2855 (1.4); 5.2602 (1.3); 5.1026 (1.3); 5.0598 (1.2); 3.9492 (13.0); 1.5614 (16.0); -0.0002 (28.1); -0.0084 (1.4) I.2-146: 1H-NMR(300.1 MHz, d6-DMSO): δ= 8.9065 (2.2); 8.8839 (2.5); 8.7724 (8.5); 8.7642 (10.4); 8.7093 (7.0); 8.7017 (6.1); 8.2112 (0.4); 7.9852 (7.0); 7.9644 (4.6); 7.9352 (4.4); 7.9228 (5.6); 7.7578 (3.4); 7.7299 (2.8); 7.6970 (2.2); 7.6715 (9.8); 7.6608 (5.8); 7.6326 (1.4); 5.1651 (0.4); 5.0985 (0.5); 5.0777 (1.4); 5.0548 (2.0); 5.0324 (1.3); 3.8443 (2.6); 3.7212 (16.0); 3.3250 (2.2); 2.5104 (17.0); 2.5047 (21.1); 2.4989 (15.0); 2.0774 (1.6); 1.4809 (15.0); 1.4582 (14.6); -0.0002 (8.4) BCS241005-Ausland STR 230 I.2-147: 1H-NMR(300.1 MHz, d6-DMSO): δ= 13.1992 (2.3); 8.9446 (2.3); 8.9222 (2.5); 8.7555 (6.7); 8.7481 (7.3); 8.6987 (10.4); 8.6906 (8.0); 8.0631 (4.0); 7.9822 (5.5); 7.9757 (6.6); 7.9622 (9.2); 7.9556 (9.0); 7.7388 (3.0); 7.7102 (3.2); 7.6745 (13.8); 7.6460 (1.6); 7.6191 (0.9); 5.1632 (0.5); 5.0343 (1.4); 5.0126 (1.9); 4.9909 (1.3); 3.3203 (4.0); 2.5080 (36.6); 2.5027 (44.2); 2.0754 (4.5); 1.4639 (16.0); 1.4411 (15.8); -0.0002 (56.5) I.2-148: 1H-NMR(300.0 MHz, d6-DMSO): δ= 12.6945 (2.0); 8.8287 (9.2); 8.8051 (8.8); 8.6495 (10.8); 8.6278 (16.0); 8.6203 (10.7); 8.0647 (0.4); 7.9841 (4.9); 7.9566 (4.6); 7.8913 (10.6); 7.7809 (1.3); 7.6368 (11.8); 7.2156 (6.8); 7.1872 (6.5); 5.2303 (0.5); 5.1824 (0.7); 5.0159 (2.6); 4.9564 (0.4); 3.8244 (15.8); 3.6702 (2.4); 3.5089 (0.4); 3.3227 (33.2); 2.7286 (0.7); 2.7228 (0.5); 2.5139 (42.3); 2.5082 (81.8); 2.5023 (111.4); 2.4966 (75.6); 2.4908 (36.0); 2.4331 (0.4); 2.2713 (0.6); 1.7545 (0.5); 1.4909 (9.0); 1.4712 (9.5); 1.3817 (1.2); 1.3298 (2.0); 1.3138 (2.1); 1.2368 (0.6); 0.0108 (2.0); -0.0002 (61.8); -0.0112 (2.0) I.2-149: 1H-NMR(300.0 MHz, d6-DMSO): δ= 8.7916 (4.9); 8.7678 (4.9); 8.6694 (6.6); 8.6622 (8.4); 8.6356 (14.2); 8.6274 (9.5); 7.9601 (2.7); 7.9319 (2.5); 7.8460 (7.4); 7.7727 (0.9); 7.7382 (0.7); 7.7176 (1.0); 7.7103 (1.1); 7.6271 (7.0); 7.2291 (5.4); 7.2000 (5.0); 5.1666 (0.4); 5.1428 (0.4); 5.0747 (1.4); 5.0541 (1.8); 5.0333 (1.3); 3.8353 (11.9); 3.8171 (5.2); 3.8058 (3.8); 3.7948 (4.2); 3.7495 (16.0); 3.6864 (1.5); 3.3231 (14.0); 2.5083 (37.9); 2.5028 (49.5); 2.4974 (35.7); 2.0758 (0.8); 1.4985 (6.4); 1.4785 (6.6); 1.3467 (1.2); 1.2334 (0.6); 0.0106 (0.8); -0.0002 (19.8); -0.0111 (0.8) I.2-150: 1H-NMR(300.0 MHz, d6-DMSO): δ= 12.6812 (7.1); 9.3083 (0.5); 9.2863 (0.4); 8.9462 (6.3); 8.9229 (7.0); 8.6615 (10.8); 8.6398 (16.0); 8.6318 (10.5); 8.4243 (1.3); 8.4162 (1.2); 8.1404 (0.4); 8.1361 (0.3); 8.0698 (0.9); 8.0647 (1.4); 8.0590 (1.0); 7.9816 (3.8); 7.9526 (3.7); 7.8822 (5.2); 7.8254 (2.2); 7.7919 (5.9); 7.6918 (5.9); 7.5930 (4.4); 7.5298 (0.5); 7.5090 (0.4); 7.2200 (4.1); 7.1910 (4.3); 5.4757 (0.3); 5.4532 (0.5); 5.4313 (0.4); 5.2000 (0.5); 5.1652 (0.4); 5.0531 (2.2); 3.9633 (0.9); 3.8961 (0.3); 3.8296 (13.3); 3.6664 (1.9); 3.3316 (59.0); 2.7319 (0.4); 2.5110 (37.0); 2.5052 (49.5); 2.4996 (34.7); 1.5357 (3.4); 1.5118 (8.6); 1.4864 (8.2); 1.3495 (1.7); 1.2670 (0.4); 1.2329 (1.2); 0.8531 (0.4); 0.0107 (0.7); -0.0002 (21.7); -0.0112 (0.7) I.2-151: 1H-NMR(300.1 MHz, d6-DMSO): δ= 8.9424 (0.3); 8.8978 (4.5); 8.8748 (4.8); 8.7809 (0.4); 8.6721 (9.2); 8.6463 (12.6); 8.6382 (9.1); 8.5027 (0.4); 7.9514 (2.9); 7.9231 (3.0); 7.8442 (4.8); 7.7363 (5.0); 7.6986 (6.3); 7.6252 (0.9); 7.6094 (0.8); 7.5896 (0.8); 7.5417 (3.6); 7.2285 (3.8); 7.1994 (4.0); 5.1637 (0.7); 5.1218 (2.0); 5.1001 (2.3); 3.9977 (0.4); 3.8389 (11.9); 3.7461 (16.0); 3.6024 (0.7); 3.5821 (0.6); 3.5129 (0.8); 3.4796 (0.4); 3.4268 (0.3); 3.3997 (0.4); 3.3200 (18.0); 3.1801 (0.3); 2.7295 (0.5); 2.7255 (0.4); 2.5029 (41.9); 2.2720 (0.4); 1.5095 (7.0); 1.4892 (7.6); 1.3806 (1.6); 1.3558 (1.7); 1.2344 (0.8); 1.2191 (0.6); -0.0002 (10.2); -0.0621 (0.3) BCS241005-Ausland STR 231 I.2-152: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6463 (2.4); 8.6402 (3.1); 8.5986 (2.6); 8.5926 (2.1); 8.3669 (1.1); 8.3628 (1.9); 8.3591 (1.1); 8.2773 (3.2); 8.2121 (0.7); 8.2090 (1.0); 8.2051 (0.8); 8.1926 (0.8); 8.1888 (1.1); 8.1856 (0.8); 8.0312 (1.4); 7.9877 (0.7); 7.9847 (0.8); 7.9803 (0.7); 7.9685 (0.8); 7.9642 (1.0); 7.9611 (0.7); 7.6853 (1.0); 7.6661 (1.8); 7.6465 (0.9); 7.2845 (0.6); 7.2613 (18.8); 5.5942 (0.8); 5.5752 (0.9); 5.5717 (0.9); 5.5526 (0.8); 3.9622 (16.0); 2.0553 (0.6); 2.0373 (0.6); 1.5762 (2.5); 0.9110 (5.0); 0.8942 (4.9); 0.6640 (4.7); 0.6472 (4.6); 0.0080 (0.6); -0.0002 (22.1); -0.0085 (0.7) I.2-153: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6455 (2.2); 8.6395 (2.8); 8.5984 (2.3); 8.5924 (1.8); 8.3664 (1.0); 8.3623 (1.7); 8.3585 (1.0); 8.2766 (2.8); 8.2119 (0.6); 8.2087 (0.9); 8.2049 (0.6); 8.1924 (0.7); 8.1886 (0.9); 8.1854 (0.6); 8.0316 (1.2); 7.9864 (0.6); 7.9833 (0.7); 7.9790 (0.6); 7.9673 (0.7); 7.9630 (0.8); 7.9598 (0.6); 7.6853 (0.9); 7.6660 (1.6); 7.6465 (0.7); 7.2778 (0.5); 7.2610 (22.0); 5.5946 (0.7); 5.5756 (0.8); 5.5720 (0.8); 5.5530 (0.7); 3.9622 (13.4); 2.0543 (0.6); 2.0363 (0.6); 1.5640 (16.0); 0.9103 (4.3); 0.8934 (4.2); 0.6641 (4.0); 0.6472 (3.9); 0.0079 (0.9); -0.0002 (25.9); -0.0085 (0.7) I.2-154: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6481 (1.5); 8.6421 (1.8); 8.5937 (1.6); 8.5877 (1.3); 8.3920 (0.6); 8.3878 (1.1); 8.3839 (0.6); 8.2691 (1.9); 8.2005 (0.6); 8.1810 (0.6); 8.0235 (0.8); 7.9887 (0.5); 7.9686 (0.6); 7.6621 (0.6); 7.6426 (1.1); 7.6234 (0.5); 7.2607 (26.6); 5.1400 (0.8); 3.9580 (9.3); 1.5534 (16.0); 0.0079 (1.0); -0.0002 (31.3); -0.0085 (0.8) I.2-155: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6479 (1.4); 8.6418 (1.8); 8.5936 (1.6); 8.5876 (1.3); 8.3919 (0.7); 8.3879 (1.2); 8.3837 (0.7); 8.2686 (2.0); 8.2005 (0.6); 8.1808 (0.7); 8.0237 (0.9); 7.9884 (0.6); 7.9691 (0.6); 7.6619 (0.6); 7.6426 (1.2); 7.6233 (0.6); 7.2608 (21.2); 5.1402 (0.9); 5.1195 (0.5); 3.9580 (9.2); 1.5553 (16.0); 0.0079 (0.9); -0.0002 (25.5); -0.0085 (0.8) I.2-158: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6275 (1.2); 8.6217 (1.5); 8.5883 (1.4); 8.5825 (1.1); 8.3428 (1.2); 8.1949 (0.6); 8.1755 (0.7); 7.9739 (0.6); 7.9545 (0.7); 7.8894 (2.7); 7.8853 (2.8); 7.8105 (1.3); 7.6703 (0.6); 7.6509 (1.1); 7.6316 (0.5); 7.2605 (18.2); 5.5285 (0.5); 5.5090 (0.6); 5.4869 (0.5); 3.9569 (7.0); 2.0077 (0.8); 1.5495 (16.0); 0.8848 (2.9); 0.8680 (2.8); 0.6405 (2.8); 0.6237 (2.7); -0.0002 (20.5); - 0.0082 (1.2) I.2-159: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6271 (0.6); 8.6215 (0.7); 8.5880 (0.7); 8.3421 (0.6); 7.8857 (1.4); 7.8109 (0.6); 7.6504 (0.5); 7.2603 (18.5); 3.9569 (3.2); 1.5432 (16.0); 0.8845 (1.4); 0.8678 (1.4); 0.6403 (1.4); 0.6237 (1.3); -0.0002 (21.4) I.2-161: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6319 (1.2); 8.6260 (1.4); 8.5867 (1.4); 8.5809 (1.1); 8.3466 (1.2); 8.1984 (0.6); 8.1787 (0.7); 7.9771 (0.6); 7.9574 (0.6); 7.7306 (1.3); 7.6741 (0.6); 7.6549 (1.0); BCS241005-Abroad STR 232 7.6354 (0.5); 7.6009 (1.0); 7.3860 (0.9); 7.2608 (13.9); 5.5332 (0.6); 3.9574 (7.0); 1.5579 (16.0); 0.8844 (2.8); 0.8676 (2.7); 0.6505 (2.7); 0.6337 (2.6); -0.0002 (15.0); -0.0083 (0.7) I.2-162: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6492 (1.9); 8.6432 (2.8); 8.6213 (2.6); 8.6152 (1.7); 8.1106 (1.3); 8.1070 (2.3); 8.1034 (1.3); 7.8914 (0.6); 7.8880 (0.7); 7.8852 (0.7); 7.8818 (0.6); 7.8695 (0.6); 7.8660 (0.7); 7.8634 (0.7); 7.8599 (0.6); 7.7020 (1.2); 7.6981 (2.1); 7.6940 (1.3); 7.6475 (0.6); 7.6435 (0.7); 7.6375 (0.6); 7.6260 (0.6); 7.6220 (0.7); 7.6159 (0.6); 7.5555 (1.3); 7.3741 (1.2); 7.2608 (21.7); 5.6079 (0.6); 5.5904 (0.8); 5.5718 (0.6); 3.9569 (13.8); 1.5556 (16.0); 1.4897 (4.8); 1.4730 (4.8); 0.0079 (1.0); -0.0002 (26.4); -0.0084 (0.9) I.2-164: 1H-NMR(400.1 MHz, d6-DMSO): δ= 12.9399 (1.8); 9.0780 (2.1); 9.0616 (2.2); 8.6488 (3.0); 8.6428 (6.5); 8.6351 (6.6); 8.6291 (3.0); 8.0954 (4.0); 8.0911 (3.8); 8.0624 (4.5); 8.0577 (4.3); 7.7824 (3.1); 7.7656 (4.9); 7.7609 (4.8); 7.7120 (5.3); 7.6910 (3.1); 7.4535 (3.0); 7.4336 (2.7); 5.3286 (1.3); 5.3117 (2.0); 5.2948 (1.3); 3.7901 (0.4); 3.3319 (15.8); 2.5930 (16.0); 2.5084 (19.7); 2.5041 (25.3); 2.4999 (18.2); 1.4667 (7.5); 1.4495 (7.4); -0.0002 (13.4); -0.0082 (0.6) I.2-165: 1H-NMR(400.1 MHz, d6-DMSO): δ= 9.0582 (1.6); 9.0418 (1.7); 8.6617 (2.5); 8.6556 (4.3); 8.6417 (4.4); 8.6358 (3.0); 8.0649 (3.0); 8.0604 (3.3); 8.0465 (3.5); 8.0417 (3.7); 7.8182 (1.5); 7.8135 (1.6); 7.7986 (1.8); 7.7939 (1.9); 7.7776 (1.4); 7.7727 (1.4); 7.7566 (2.4); 7.7517 (2.5); 7.7157 (3.9); 7.6947 (2.1); 7.4759 (2.2); 7.4562 (2.1); 5.3154 (1.0); 5.2983 (1.6); 5.2814 (1.1); 5.2643 (0.4); 3.7886 (16.0); 3.3240 (26.0); 2.6712 (0.5); 2.6667 (0.5); 2.5772 (12.7); 2.5067 (37.5); 2.5024 (48.6); 2.4981 (37.3); 2.0757 (0.4); 1.4691 (5.9); 1.4519 (6.0); -0.0002 (15.4) I.2-166: 1H-NMR(400.1 MHz, d6-DMSO): δ= 12.9448 (2.5); 9.1858 (2.0); 9.1694 (2.1); 8.6573 (2.9); 8.6513 (7.1); 8.6448 (7.3); 8.6387 (3.0); 8.0921 (3.7); 8.0880 (3.6); 7.9585 (2.9); 7.9547 (4.3); 7.9510 (2.8); 7.7796 (2.0); 7.7748 (1.9); 7.7600 (2.4); 7.7549 (3.0); 7.7471 (3.2); 7.7279 (3.2); 7.7259 (3.2); 7.4498 (3.0); 7.4299 (2.7); 5.3495 (1.2); 5.3326 (1.9); 5.3157 (1.2); 3.3326 (11.2); 2.5902 (16.0); 2.5145 (9.6); 2.5105 (17.8); 2.5061 (22.9); 2.5016 (16.2); 2.4975 (7.6); 1.4836 (7.4); 1.4665 (7.3); 0.0078 (0.6); 0.0012 (7.9); -0.0002 (8.6) I.2-167: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6318 (2.1); 8.6258 (3.6); 8.6107 (3.0); 8.6046 (1.7); 8.0352 (0.6); 8.0300 (0.8); 8.0251 (0.6); 8.0211 (0.6); 8.0163 (0.8); 8.0112 (0.6); 7.8311 (0.5); 7.8254 (0.5); 7.8142 (0.6); 7.8062 (0.6); 7.8003 (0.5); 7.7891 (0.5); 7.6993 (1.4); 7.6952 (2.3); 7.6912 (1.4); 7.5518 (1.4); 7.5497 (1.2); 7.3759 (1.2); 7.3739 (1.2); 7.2616 (14.6); 7.2059 (0.5); 7.1866 (0.6); 5.6037 (0.7); 5.5865 (0.8); 5.5846 (0.8); 5.5674 (0.7); 3.9802 (16.0); 1.5756 (15.5); 1.5008 (5.2); 1.4840 (5.2); 0.8819 (0.7); 0.0080 (0.5); -0.0002 (17.4) BCS241005-Ausland STR 233 I.2-168: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6262 (2.3); 8.6202 (3.4); 8.5960 (2.7); 8.5900 (1.9); 8.0363 (0.5); 8.0312 (0.8); 8.0263 (0.6); 8.0223 (0.6); 8.0173 (0.8); 8.0124 (0.5); 7.8395 (0.5); 7.8225 (0.5); 7.8164 (0.7); 7.8145 (0.7); 7.8085 (0.6); 7.7972 (0.6); 7.7916 (1.4); 7.7878 (1.4); 7.7839 (1.1); 7.6663 (1.1); 7.6613 (1.0); 7.6455 (1.6); 7.6405 (1.5); 7.5619 (3.0); 7.5412 (1.9); 7.2617 (13.5); 7.2110 (0.5); 7.1915 (0.5); 5.6114 (0.6); 5.5943 (0.8); 5.5923 (0.8); 5.5752 (0.6); 3.9777 (16.0); 1.5816 (12.5); 1.5010 (5.2); 1.4842 (5.2); 1.2643 (0.6); 1.2599 (0.6); 0.8819 (1.1); -0.0002 (15.8) I.2-169: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7110 (0.6); 8.7049 (0.8); 8.6657 (0.9); 8.6596 (0.7); 7.9187 (0.6); 3.3216 (16.0); 2.5242 (0.9); 2.5195 (1.2); 2.5107 (14.9); 2.5062 (32.0); 2.5016 (44.1); 2.4970 (30.6); 2.4925 (13.6); 1.4893 (1.0); 1.4722 (1.0); 0.0080 (1.1); -0.0002 (37.9); -0.0085 (1.1) I.2-170: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1596 (0.7); 9.1427 (0.7); 8.7063 (1.6); 8.7002 (2.1); 8.6618 (2.3); 8.6557 (1.8); 7.9049 (1.1); 7.9013 (1.0); 7.8921 (1.5); 7.8873 (1.1); 7.8819 (0.6); 7.8711 (1.2); 7.8661 (1.0); 7.7885 (1.9); 7.7677 (1.3); 5.3302 (0.7); 4.0558 (0.7); 4.0380 (2.1); 4.0203 (2.2); 4.0025 (0.7); 3.3190 (16.0); 2.6704 (0.6); 2.5241 (1.7); 2.5194 (2.5); 2.5106 (34.3); 2.5061 (73.1); 2.5015 (100.4); 2.4970 (68.8); 2.4924 (30.1); 2.3286 (0.6); 1.9888 (9.9); 1.9087 (1.4); 1.4872 (2.5); 1.4701 (2.5); 1.3553 (1.0); 1.1925 (2.7); 1.1747 (5.6); 1.1569 (2.7); 0.0079 (2.5); -0.0002 (83.3); -0.0085 (2.3) I.2-171: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.2002 (1.7); 9.1786 (1.8); 8.6149 (14.7); 7.9657 (3.0); 7.9505 (4.5); 7.9425 (4.4); 7.9259 (2.7); 7.9195 (2.2); 7.8882 (1.8); 7.8802 (1.5); 7.8595 (2.0); 7.8517 (1.8); 7.8082 (3.9); 7.7805 (2.8); 7.2881 (2.8); 7.2591 (2.6); 5.3847 (1.0); 5.3626 (1.6); 5.3401 (1.1); 3.8907 (16.0); 3.3297 (5.0); 2.5102 (7.8); 2.5044 (10.4); 2.4987 (7.7); 1.4754 (5.9); 1.4526 (5.9); -0.0002 (5.6) I.2-172: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.1887 (1.4); 9.1668 (1.4); 8.6344 (1.3); 8.6254 (9.3); 8.6165 (1.2); 7.9564 (2.6); 7.9525 (2.6); 7.9455 (4.4); 7.9375 (4.4); 7.9286 (2.4); 7.9185 (2.7); 7.9117 (1.9); 7.9002 (1.8); 7.8923 (1.3); 7.8104 (3.3); 7.7827 (2.2); 7.3140 (2.3); 7.2855 (2.1); 5.3731 (0.9); 5.3503 (1.4); 5.3281 (0.9); 3.8932 (14.4); 3.7640 (16.0); 3.3346 (10.6); 2.5098 (7.2); 2.5040 (9.2); 2.4983 (6.4); 1.4808 (5.2); 1.4579 (5.0); -0.0002 (4.0) I.2-173: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.1321 (1.6); 9.1101 (1.6); 8.6270 (9.6); 8.1369 (3.1); 8.1302 (3.4); 7.9515 (2.6); 7.9440 (3.8); 7.9238 (1.9); 7.9139 (2.2); 7.9062 (1.6); 7.8953 (1.9); 7.8853 (2.6); 7.8775 (1.9); 7.6561 (1.6); 7.6315 (1.3); 7.6276 (1.3); 7.3175 (2.6); 7.2886 (2.4); 5.3609 (1.0); 5.3383 (1.5); 5.3156 (1.0); 3.8975 (15.0); 3.7667 (16.0); 3.3322 (16.4); 2.5121 (4.0); 2.5066 (5.1); 1.4786 (5.6); 1.4559 (5.4); -0.0002 (2.4) BCS241005-Ausland STR 234 I.2-174: 1H-NMR(400.1 MHz, d6-DMSO): δ= 9.0133 (3.7); 8.9356 (0.3); 8.7100 (13.7); 8.7046 (16.0); 8.6682 (11.1); 8.1252 (0.7); 8.0754 (8.6); 8.0091 (0.5); 7.9177 (5.2); 7.8578 (8.5); 7.8537 (8.2); 7.8364 (9.9); 7.8321 (9.5); 7.6467 (10.6); 7.6255 (8.6); 7.4995 (15.3); 7.4793 (13.9); 4.9534 (2.8); 3.9643 (0.8); 3.9343 (0.4); 3.8525 (3.0); 3.8214 (3.6); 3.7609 (3.0); 3.7219 (3.1); 3.3361 (161.0); 3.3125 (2.3); 2.5417 (0.5); 2.5100 (35.8); 2.5057 (46.6); 2.5015 (33.5); 2.3325 (0.5); 2.1570 (6.4); 2.0114 (0.4); 1.4133 (11.7); 1.2994 (0.4); 1.2322 (2.1); 0.8515 (0.4); -0.0002 (16.1) I.2-175: 1H-NMR(300.0 MHz, d6-DMSO): δ= 8.8849 (6.4); 8.8609 (6.2); 8.6674 (10.2); 8.6410 (15.0); 8.6329 (10.2); 7.9811 (1.1); 7.9458 (3.1); 7.9166 (3.2); 7.8342 (6.2); 7.7311 (9.0); 7.2282 (4.0); 7.1980 (4.1); 5.2079 (0.5); 5.1827 (0.6); 5.0780 (2.1); 3.9823 (0.4); 3.9676 (0.5); 3.8373 (13.6); 3.7365 (16.0); 3.6549 (1.7); 3.6144 (0.7); 3.5508 (0.4); 3.5046 (0.3); 3.3243 (106.6); 3.3007 (3.2); 2.7335 (0.4); 2.5083 (39.0); 2.5030 (50.8); 2.2735 (0.4); 1.6144 (0.4); 1.5833 (0.4); 1.5088 (7.6); 1.4891 (7.8); 1.3495 (1.6); 1.2341 (2.4); 1.0589 (0.3); 0.8523 (0.6); 0.8238 (0.4); 0.8057 (0.4); -0.0001 (20.1) I.2-176: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.1342 (1.5); 9.1123 (1.6); 8.7130 (0.4); 8.7039 (3.1); 8.6955 (4.4); 8.6863 (0.5); 8.6689 (4.1); 8.6608 (2.8); 8.0941 (3.2); 8.0873 (3.6); 8.0579 (2.9); 8.0507 (3.2); 7.9238 (1.4); 7.9163 (1.3); 7.8961 (1.9); 7.8887 (1.8); 7.8787 (1.6); 7.8717 (1.4); 7.8500 (1.9); 7.8430 (1.7); 7.7347 (3.3); 7.7260 (0.6); 7.7182 (0.6); 7.7070 (2.5); 7.6529 (1.4); 7.6482 (1.6); 7.6342 (0.7); 7.6241 (1.2); 7.6197 (1.2); 7.5968 (0.4); 5.3023 (0.8); 5.2800 (1.3); 5.2574 (0.8); 3.8871 (2.2); 3.8290 (16.0); 3.6192 (1.9); 3.3381 (21.4); 3.3140 (0.5); 2.5113 (6.3); 2.5055 (8.4); 2.4998 (5.9); 1.5236 (0.7); 1.4927 (5.0); 1.4698 (4.9); -0.0002 (4.2) I.2-177: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.1944 (1.3); 9.1723 (1.3); 8.7043 (2.8); 8.6960 (4.0); 8.6696 (4.1); 8.6615 (2.7); 8.0543 (2.8); 8.0471 (3.0); 7.9288 (2.4); 7.9217 (3.5); 7.9126 (2.5); 7.9016 (2.0); 7.8940 (1.8); 7.8848 (2.2); 7.8782 (1.6); 7.8052 (3.1); 7.7775 (1.9); 7.7323 (3.2); 7.7046 (2.5); 5.3178 (0.7); 5.2951 (1.2); 5.2725 (0.7); 3.8882 (1.2); 3.8292 (16.0); 3.6169 (0.9); 3.5696 (1.7); 3.3367 (21.9); 3.3135 (0.5); 2.5166 (3.4); 2.5108 (6.8); 2.5049 (9.0); 2.4990 (6.2); 1.5284 (0.3); 1.4968 (4.6); 1.4739 (4.5); -0.0002 (5.2) I.2-178: 1H-NMR(300.0 MHz, d6-DMSO): δ= 13.5115 (0.9); 13.4382 (0.4); 9.2017 (4.6); 9.1802 (4.8); 8.6875 (7.4); 8.6794 (12.8); 8.6593 (13.1); 8.6513 (8.4); 8.0563 (9.0); 8.0492 (9.8); 7.9326 (8.0); 7.9219 (7.5); 7.8938 (6.7); 7.8874 (5.8); 7.8756 (4.6); 7.8683 (4.1); 7.8480 (5.7); 7.8406 (5.6); 7.7973 (10.2); 7.7696 (6.8); 7.6978 (10.1); 7.6701 (7.6); 5.3422 (0.6); 5.3196 (2.6); 5.2969 (4.1); 5.2741 (2.7); 5.2516 (0.7); 3.3272 (10.6); 2.5102 (20.4); 2.5045 (26.8); 2.4992 (19.9); 1.4897 (16.0); 1.4668 (15.8); 1.2321 (1.0); -0.0001 (12.0) BCS241005-Ausland STR 235 I.2-179: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.1431 (4.5); 9.1217 (4.6); 8.6823 (7.8); 8.6743 (13.2); 8.6550 (13.7); 8.6470 (8.4); 8.6287 (0.4); 8.1130 (9.8); 8.1061 (10.3); 8.0415 (8.4); 8.0343 (9.1); 7.8897 (4.6); 7.8827 (4.4); 7.8609 (6.4); 7.8544 (9.0); 7.8489 (4.8); 7.8280 (5.4); 7.8207 (5.3); 7.6885 (10.0); 7.6610 (7.4); 7.6439 (4.7); 7.6395 (5.0); 7.6154 (3.9); 7.6109 (4.0); 5.3269 (0.6); 5.3045 (2.7); 5.2819 (4.1); 5.2595 (2.7); 5.2387 (0.6); 3.6134 (0.4); 3.5908 (0.3); 3.5095 (4.4); 3.4635 (0.8); 3.3276 (6.2); 2.5092 (26.4); 2.5035 (34.7); 2.4977 (24.8); 1.9110 (0.4); 1.4809 (16.0); 1.4581 (15.7); 1.2577 (0.3); 1.2378 (0.6); -0.0002 (13.0) I.2-180: 1H-NMR(400.1 MHz, d6-DMSO): δ= 9.1468 (1.6); 9.1303 (1.7); 8.6177 (15.4); 8.1501 (3.7); 8.1448 (3.7); 7.9591 (3.2); 7.9532 (3.6); 7.9155 (1.8); 7.9102 (1.7); 7.8940 (2.2); 7.8887 (2.2); 7.8828 (1.8); 7.8768 (1.5); 7.8612 (1.8); 7.8553 (1.6); 7.6556 (1.6); 7.6522 (1.6); 7.6340 (1.4); 7.6307 (1.3); 7.2907 (2.9); 7.2689 (2.6); 5.3677 (1.0); 5.3508 (1.5); 5.3339 (1.0); 3.8960 (16.0); 3.3419 (1.7); 2.5157 (2.2); 2.5113 (4.3); 2.5069 (5.7); 2.5024 (4.0); 2.4981 (1.8); 2.0800 (0.4); 1.4702 (5.7); 1.4530 (5.6); - 0.0002 (2.2) I.2-181: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6402 (1.0); 8.6351 (1.1); 8.5724 (1.3); 8.5670 (1.2); 8.1952 (1.7); 8.1906 (1.7); 7.7260 (0.8); 7.7213 (0.8); 7.7092 (1.6); 7.7057 (3.0); 7.7015 (2.2); 7.5670 (1.4); 7.4492 (1.4); 7.4295 (1.2); 7.3739 (1.4); 7.3715 (1.6); 7.2623 (7.1); 5.6746 (0.6); 5.6576 (0.7); 5.6386 (0.6); 5.2998 (8.9); 3.9037 (16.0); 2.7051 (9.3); 1.6318 (0.7); 1.4554 (4.6); 1.4388 (4.6); -0.0002 (10.8) I.2-182: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6407 (0.9); 8.6352 (1.0); 8.5726 (1.2); 8.5670 (1.0); 8.1954 (1.7); 8.1905 (1.7); 7.7260 (0.9); 7.7210 (0.9); 7.7094 (1.5); 7.7057 (3.1); 7.7014 (2.3); 7.5670 (1.3); 7.4492 (1.4); 7.4295 (1.2); 7.3740 (1.4); 7.3716 (1.5); 7.3568 (0.5); 7.2622 (6.7); 5.6747 (0.6); 5.6577 (0.7); 5.6385 (0.6); 5.2998 (10.2); 3.9037 (16.0); 2.7051 (9.0); 1.6347 (1.0); 1.4554 (5.0); 1.4388 (5.0); - 0.0002 (10.0) I.2-183: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6351 (1.2); 8.6293 (1.4); 8.5564 (1.6); 8.5505 (1.4); 8.1976 (1.8); 8.1927 (1.8); 7.8120 (1.1); 7.8083 (1.4); 7.8046 (1.1); 7.7338 (0.9); 7.7288 (0.9); 7.7141 (1.1); 7.7092 (1.0); 7.6761 (1.0); 7.6711 (1.0); 7.6552 (1.5); 7.6503 (1.4); 7.5603 (2.7); 7.5395 (1.9); 7.4484 (1.4); 7.4287 (1.2); 7.3870 (0.5); 7.3677 (0.6); 7.2620 (7.2); 5.6843 (0.6); 5.6672 (0.8); 5.6482 (0.6); 5.2997 (4.9); 3.9013 (16.0); 2.7037 (9.2); 1.6301 (0.8); 1.4553 (5.1); 1.4386 (5.0); -0.0002 (10.6) I.2-184: 1H-NMR(300.1 MHz, d6-DMSO): δ= 9.2840 (1.4); 9.2620 (1.5); 8.7065 (2.6); 8.6984 (4.1); 8.6746 (4.3); 8.6665 (2.8); 8.3019 (2.0); 8.2972 (3.6); 8.2923 (2.2); 8.1844 (3.0); 8.1795 (1.9); 8.0950 (1.7); 8.0887 (3.1); 8.0835 (2.3); 8.0563 (2.5); 8.0506 (4.0); 8.0452 (3.1); 8.0199 (1.7); 8.0154 (1.3); 7.9899 (1.4); 7.9684 (1.3); 7.9635 (1.6); 7.6909 (1.5); 7.6651 (2.6); 7.6393 (1.2); 5.3431 (0.8); 5.3206 (1.3); 5.2980 (0.9); 3.8209 (16.0); 3.3307 (26.6); 2.6081 (15.4); 2.5148 (11.7); 2.5093 (23.2); 2.5034 (30.7); 2.4976 (22.3); 1.5114 (5.0); 1.4885 (5.0); 0.0107 (0.8); -0.0002 (19.8); -0.0111 (0.8) BCS241005-Ausland STR 236 I.2-185: 1H-NMR(300.0 MHz, d6-DMSO): δ= 9.0584 (3.5); 9.0393 (3.6); 8.7119 (10.1); 8.7043 (13.6); 8.6700 (11.1); 8.1349 (1.3); 8.0303 (0.8); 8.0121 (0.6); 7.9843 (0.8); 7.9790 (0.8); 7.8968 (15.5); 7.8853 (12.2); 7.8561 (11.6); 7.8508 (10.4); 7.8206 (1.8); 7.7970 (16.0); 7.7693 (8.5); 7.7238 (0.6); 7.5539 (0.4); 7.5308 (0.7); 7.5034 (1.1); 7.4790 (8.5); 7.4525 (7.4); 4.9871 (3.0); 3.9842 (0.3); 3.9635 (2.6); 3.8487 (3.7); 3.8362 (3.2); 3.7914 (4.1); 3.5123 (3.5); 3.4153 (0.3); 3.3962 (0.4); 3.3717 (0.3); 3.3288 (58.6); 3.3043 (1.4); 2.6924 (0.5); 2.5062 (27.7); 2.2733 (0.4); 2.1472 (11.6); 2.0646 (1.1); 1.5381 (0.8); 1.5144 (0.9); 1.4765 (2.2); 1.4296 (10.3); 1.4129 (10.1); 1.2355 (0.6); 1.1976 (0.4); 1.1641 (0.4); 1.1309 (0.4); 1.1101 (0.4); 1.1012 (0.4); -0.0001 (10.1) I.2-186: 1H-NMR(300.0 MHz, d6-DMSO): δ= 13.0416 (0.4); 13.0272 (0.5); 12.9659 (0.5); 12.9401 (0.6); 12.9074 (0.5); 12.8257 (0.4); 12.7992 (0.4); 9.0358 (3.7); 9.0126 (3.8); 8.9600 (0.4); 8.6902 (10.4); 8.6822 (16.0); 8.6557 (12.8); 8.6480 (9.3); 8.0991 (10.5); 8.0935 (11.1); 8.0167 (0.5); 8.0008 (0.5); 7.9803 (0.6); 7.9292 (6.0); 7.9015 (6.8); 7.8803 (6.8); 7.8736 (6.6); 7.8517 (8.1); 7.8450 (8.2); 7.7730 (0.7); 7.7111 (0.4); 7.6416 (6.8); 7.6145 (5.5); 7.4750 (9.1); 7.4482 (8.0); 4.9533 (2.0); 3.9637 (0.5); 3.5333 (0.4); 3.5092 (0.6); 3.4912 (0.4); 3.3272 (6.6); 3.1488 (0.4); 2.7240 (0.5); 2.5035 (51.7); 2.2661 (0.7); 2.1609 (8.1); 2.0192 (0.3); 1.4038 (7.6); 1.2755 (0.4); 1.2328 (0.5); 0.0690 (0.5); -0.0001 (23.2) I.2-187: 1H-NMR(400.1 MHz, d6-DMSO): δ= 12.8036 (0.4); 12.7800 (0.5); 12.7048 (1.7); 8.8769 (8.0); 8.8592 (7.5); 8.6524 (8.1); 8.6305 (10.7); 8.1621 (0.3); 8.1197 (0.6); 8.0623 (1.0); 7.9834 (4.4); 7.9597 (4.5); 7.9425 (5.8); 7.8981 (5.5); 7.8243 (0.9); 7.8012 (1.3); 7.7623 (3.1); 7.7410 (3.2); 7.6181 (0.9); 7.5688 (3.5); 7.5498 (2.8); 7.2616 (0.3); 7.2211 (4.9); 7.1993 (5.0); 5.2053 (0.6); 5.1913 (0.6); 5.0730 (0.4); 5.0183 (2.6); 3.9633 (1.3); 3.8302 (16.0); 3.8071 (3.2); 3.7218 (1.1); 3.6736 (2.4); 3.5090 (0.3); 3.4069 (0.5); 3.3332 (59.6); 3.2502 (0.4); 2.6723 (0.5); 2.5078 (55.8); 2.5035 (74.6); 2.4992 (54.2); 2.3305 (0.4); 2.0765 (0.6); 1.4962 (9.1); 1.4814 (9.4); 1.4335 (1.2); 1.4062 (0.6); 1.3198 (2.2); 1.2361 (0.4); 0.0078 (1.4); -0.0002 (34.7) I.2-188: 1H-NMR(300.0 MHz, d6-DMSO): δ= 8.8357 (5.0); 8.8117 (5.0); 8.6647 (9.0); 8.6403 (13.0); 8.6323 (8.8); 8.2109 (0.5); 8.1305 (0.4); 8.0755 (0.4); 7.9687 (3.1); 7.9396 (3.0); 7.8888 (4.6); 7.8604 (5.1); 7.7301 (2.2); 7.7095 (2.8); 7.5764 (3.2); 7.5508 (2.1); 7.2349 (5.2); 7.2058 (4.9); 5.1993 (0.5); 5.1650 (0.5); 5.0842 (1.6); 5.0641 (2.0); 3.9976 (0.3); 3.9128 (0.4); 3.8412 (12.5); 3.7411 (16.0); 3.5081 (0.4); 3.3244 (83.2); 3.3002 (2.6); 2.5853 (0.4); 2.5030 (44.0); 1.6259 (0.4); 1.5957 (0.5); 1.5031 (7.1); 1.4834 (7.3); 1.4151 (1.1); 1.3919 (1.3); 1.3382 (1.5); 1.2718 (0.6); 1.2578 (0.7); 1.2332 (1.8); 0.9125 (0.5); 0.8525 (0.4); 0.8272 (0.4); -0.0002 (16.0) I.2-189: 1H-NMR(400.1 MHz, d6-DMSO): δ= 9.0786 (1.2); 9.0648 (1.3); 8.6922 (4.8); 8.6861 (6.5); 8.6576 (4.2); 8.6518 (3.3); 7.9144 (5.7); 7.8940 (4.5); 7.8893 (3.9); 7.8731 (4.1); 7.8683 (3.5); 7.7904 BCS241005-Foreign STR 237 (5.9); 7.7694 (4.1); 7.4531 (2.0); 7.4334 (1.8); 4.9806 (0.7); 3.5080 (1.7); 3.3316 (35.8); 2.5117 (15.0); 2.5074 (30.6); 2.5029 (40.9); 2.4985 (29.0); 2.4941 (13.5); 2.1518 (2.2); 2.0762 (16.0); 1.4125 (1.9); 0.0080 (0.7); -0.0002 (17.9); -0.0084 (0.6) I.2-190: 1H-NMR(400.1 MHz, d6-DMSO): δ= 12.7726 (0.4); 12.7018 (1.3); 8.9265 (9.1); 8.9088 (9.0); 8.6555 (8.1); 8.6328 (11.1); 8.1587 (0.6); 7.9667 (3.9); 7.9484 (4.1); 7.8782 (6.4); 7.7934 (7.2); 7.7611 (5.0); 7.7186 (4.7); 7.6986 (2.6); 7.2169 (3.9); 7.1954 (4.2); 5.2260 (0.6); 5.0863 (0.5); 5.0402 (2.6); 3.8898 (0.4); 3.8290 (16.0); 3.7706 (0.7); 3.7493 (0.5); 3.6394 (2.4); 3.4249 (0.4); 3.3352 (40.2); 2.6735 (0.4); 2.5403 (0.5); 2.5084 (49.5); 2.5040 (66.2); 2.4997 (47.2); 2.3303 (0.4); 2.0773 (0.4); 1.5027 (9.1); 1.4877 (9.2); 1.3308 (2.0); 0.0079 (1.2); -0.0001 (35.3); -0.0084 (1.2) I.2-191: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6263 (1.5); 8.6205 (1.8); 8.5757 (2.1); 8.5699 (1.7); 8.3527 (1.2); 8.3487 (2.1); 8.3446 (1.2); 8.1977 (0.7); 8.1947 (1.1); 8.1782 (0.8); 8.1750 (1.2); 7.9937 (0.9); 7.9742 (1.0); 7.9417 (2.4); 7.9366 (2.4); 7.6846 (1.1); 7.6794 (1.0); 7.6728 (1.2); 7.6638 (1.5); 7.6586 (1.5); 7.6534 (2.1); 7.6339 (1.0); 7.5497 (2.8); 7.5289 (2.1); 7.2614 (29.3); 7.1659 (0.6); 7.1427 (0.6); 5.5499 (0.8); 5.5310 (1.0); 5.5271 (1.0); 5.5084 (0.8); 3.9557 (16.0); 2.0107 (0.7); 1.9932 (0.7); 1.5750 (14.2); 0.8808 (5.3); 0.8640 (5.1); 0.6438 (5.0); 0.6269 (4.9); 0.0079 (1.1); -0.0002 (33.2); -0.0085 (0.9) I.2-192: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6255 (1.0); 8.6203 (1.1); 8.5759 (1.4); 8.5702 (1.2); 8.3531 (1.1); 8.3491 (1.9); 8.3451 (1.1); 8.1978 (0.7); 8.1946 (1.0); 8.1910 (0.7); 8.1783 (0.8); 8.1749 (1.1); 8.1714 (0.7); 7.9973 (0.6); 7.9940 (0.9); 7.9901 (0.6); 7.9781 (0.7); 7.9744 (1.0); 7.9709 (0.7); 7.9418 (2.4); 7.9367 (2.5); 7.6845 (1.2); 7.6793 (1.2); 7.6727 (1.1); 7.6637 (1.6); 7.6585 (1.6); 7.6533 (2.0); 7.6339 (0.9); 7.5490 (2.9); 7.5282 (2.1); 7.2624 (10.2); 7.1668 (0.6); 7.1445 (0.6); 5.5498 (0.8); 5.5311 (1.0); 5.5269 (0.9); 5.5082 (0.8); 3.9557 (16.0); 2.0104 (0.7); 1.9930 (0.7); 1.6113 (4.6); 0.8808 (5.2); 0.8639 (5.0); 0.6437 (4.8); 0.6268 (4.7); -0.0002 (11.9) I.2-193: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6306 (2.4); 8.6246 (3.2); 8.5849 (2.7); 8.5789 (2.1); 8.3719 (1.1); 8.3678 (1.9); 8.3640 (1.1); 8.1917 (0.7); 8.1883 (1.0); 8.1845 (0.8); 8.1721 (0.8); 8.1683 (1.1); 8.1650 (0.8); 8.0198 (1.5); 8.0161 (2.8); 8.0124 (1.6); 7.9837 (0.7); 7.9794 (0.9); 7.9763 (0.7); 7.9646 (0.8); 7.9603 (1.0); 7.9572 (0.7); 7.8439 (1.4); 7.8395 (2.2); 7.8355 (1.5); 7.7584 (1.6); 7.7541 (2.2); 7.7499 (1.4); 7.6468 (1.0); 7.6275 (1.8); 7.6081 (0.8); 7.2606 (56.4); 7.2182 (0.6); 7.1990 (0.5); 5.1087 (0.8); 5.0880 (1.5); 5.0673 (0.8); 3.9526 (16.0); 3.4948 (1.0); 1.5516 (8.0); 1.2093 (0.6); 1.1887 (0.6); 0.3776 (0.6); 0.3366 (0.6); 0.3245 (0.6); 0.0583 (0.5); 0.0468 (0.5); 0.0348 (0.5); 0.0223 (0.5); 0.0080 (2.1); -0.0002 (66.6); -0.0085 (1.7) I.2-194: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6313 (2.2); 8.6252 (2.8); 8.5849 (2.5); 8.5788 (2.0); 8.3723 (1.0); 8.3683 (2.0); 8.3644 (1.1); 8.1916 (0.7); 8.1883 (1.0); 8.1846 (0.8); 8.1721 (0.8); 8.1685 (1.1); BCS241005-International STR 238 8.1650 (0.8); 8.0205 (1.4); 8.0168 (2.8); 8.0131 (1.6); 7.9852 (0.7); 7.9820 (0.9); 7.9778 (0.7); 7.9660 (0.8); 7.9619 (1.0); 7.9587 (0.8); 7.8430 (1.4); 7.8387 (2.2); 7.8346 (1.5); 7.7592 (1.5); 7.7550 (2.3); 7.7507 (1.4); 7.6471 (1.0); 7.6278 (1.8); 7.6086 (0.9); 7.2613 (20.9); 7.2292 (0.5); 7.2100 (0.6); 5.1071 (0.8); 5.0864 (1.5); 5.0658 (0.8); 3.9526 (16.0); 3.4925 (6.2); 1.5720 (1.3); 1.2098 (0.6); 1.1893 (0.6); 0.3774 (0.6); 0.3368 (0.6); 0.3246 (0.6); 0.0462 (0.5); 0.0319 (0.6); 0.0080 (0.8); -0.0002 (24.5); -0.0085 (0.8) I.2-195: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6313 (1.1); 8.6253 (1.4); 8.5850 (1.5); 8.5790 (1.2); 8.3726 (0.7); 8.3684 (1.4); 8.3644 (0.8); 8.1890 (0.7); 8.1727 (0.5); 8.1691 (0.8); 8.1657 (0.5); 7.9782 (0.6); 7.9623 (0.5); 7.9582 (0.7); 7.8807 (3.7); 7.8764 (4.1); 7.8065 (1.1); 7.8022 (1.9); 7.7978 (0.9); 7.6479 (0.7); 7.6285 (1.3); 7.6091 (0.6); 7.2611 (24.2); 5.1135 (0.6); 5.0928 (1.1); 5.0722 (0.6); 3.9530 (10.9); 1.5601 (16.0); 0.0079 (0.9); -0.0002 (27.7); -0.0085 (0.8) I.2-196: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6311 (0.7); 8.6250 (0.9); 8.5848 (0.8); 8.5788 (0.6); 8.3682 (0.6); 7.8806 (1.6); 7.8762 (1.8); 7.8022 (0.8); 7.6283 (0.5); 7.2610 (11.5); 3.9530 (4.7); 1.5588 (16.0); - 0.0002 (13.3) I.2-200: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1701 (1.7); 9.1525 (1.7); 8.6905 (3.9); 8.6845 (6.1); 8.6652 (7.0); 8.6591 (4.7); 8.2043 (2.1); 8.2003 (3.7); 8.1965 (2.1); 8.0688 (1.3); 8.0658 (1.9); 8.0618 (1.3); 8.0494 (1.5); 8.0463 (2.0); 8.0424 (1.5); 8.0136 (2.9); 8.0095 (6.2); 8.0055 (4.3); 8.0018 (1.3); 7.9900 (1.5); 7.9856 (1.8); 7.9826 (1.2); 7.7604 (5.1); 7.7583 (6.5); 7.7566 (6.0); 7.7545 (4.7); 7.6865 (1.9); 7.6673 (3.3); 7.6480 (1.5); 5.1685 (0.5); 5.1531 (0.9); 5.1361 (0.9); 5.1318 (0.9); 5.1148 (0.5); 4.0566 (1.1); 4.0389 (3.4); 4.0211 (3.5); 4.0034 (1.1); 3.6019 (0.5); 3.3258 (15.1); 2.6721 (0.6); 2.5258 (1.7); 2.5211 (2.6); 2.5123 (35.0); 2.5078 (74.6); 2.5032 (102.7); 2.4986 (70.3); 2.4941 (30.6); 2.3348 (0.5); 2.3303 (0.7); 1.9897 (16.0); 1.9666 (0.5); 1.9500 (0.7); 1.9294 (0.8); 1.9103 (7.2); 1.8864 (0.6); 1.8712 (0.8); 1.8526 (1.0); 1.8340 (0.5); 1.7602 (0.6); 1.3562 (1.2); 1.1932 (4.5); 1.1754 (9.0); 1.1577 (4.4); 0.8098 (3.4); 0.7916 (7.6); 0.7732 (3.1); 0.0080 (2.0); -0.0002 (66.4); -0.0085 (1.9) I.2-201: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4422 (4.3); 9.4257 (4.4); 8.7055 (10.2); 8.6994 (14.0); 8.6714 (16.0); 8.6653 (11.8); 8.2215 (5.0); 8.2174 (8.9); 8.2136 (5.0); 8.0556 (2.7); 8.0526 (4.5); 8.0482 (3.9); 8.0442 (4.4); 8.0402 (5.6); 8.0366 (11.3); 8.0325 (14.0); 8.0286 (9.8); 8.0247 (5.1); 8.0206 (5.4); 8.0177 (2.7); 7.7852 (6.3); 7.7827 (6.3); 7.7684 (5.4); 7.7659 (6.1); 7.6540 (4.5); 7.6348 (8.0); 7.6154 (3.8); 4.6665 (2.9); 4.6501 (3.2); 4.6434 (3.2); 4.6268 (3.0); 4.0568 (0.7); 4.0390 (2.3); 4.0213 (2.3); 4.0035 (0.8); 3.8447 (1.1); 3.6020 (0.6); 3.5695 (0.5); 3.3262 (15.5); 2.6768 (0.8); 2.6723 (1.2); 2.6676 (0.8); 2.5260 (3.8); 2.5214 (5.1); 2.5125 (65.9); 2.5080 (141.4); 2.5035 (194.9); 2.4989 (133.8); 2.4943 (58.4); 2.3351 (1.0); 2.3306 (1.2); 2.3260 (0.8); 2.2011 (1.0); 2.1840 (0.5); 1.9899 (10.5); 1.9106 (9.8); 1.7601 (0.7); 1.3660 (0.9); 1.3564 (5.4); 1.3459 (1.8); 1.3346 (1.7); 1.3231 (1.8); 1.3139 (1.1); 1.3029 BCS241005-Foreign STR 239 (0.8); 1.2336 (0.8); 1.1933 (3.0); 1.1755 (6.0); 1.1577 (2.8); 0.5405 (0.6); 0.5264 (0.9); 0.5180 (1.5); 0.5066 (2.0); 0.4980 (1.5); 0.4947 (1.5); 0.4837 (1.2); 0.4730 (0.8); 0.4111 (0.7); 0.3970 (1.3); 0.3857 (1.6); 0.3764 (2.0); 0.3653 (1.6); 0.3540 (1.0); 0.3432 (0.6); 0.2894 (0.8); 0.2776 (1.6); 0.2658 (2.2); 0.2539 (2.2); 0.2404 (1.5); 0.2286 (0.6); 0.0080 (3.9); -0.0002 (130.9); -0.0085 (3.4); -0.1275 (0.7); - 0.1398 (1.7); -0.1509 (2.3); -0.1634 (2.1); -0.1765 (1.4); -0.1881 (0.6) I.2-206: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6161 (2.2); 8.6101 (2.8); 8.5662 (2.4); 8.5601 (1.9); 7.7145 (1.3); 7.7105 (2.2); 7.7064 (1.4); 7.6045 (2.4); 7.5992 (2.6); 7.5645 (1.3); 7.5624 (1.2); 7.4742 (2.1); 7.4689 (1.9); 7.3789 (0.9); 7.3763 (1.2); 7.3743 (1.2); 7.3053 (0.5); 7.2852 (0.5); 7.2665 (3.2); 5.7446 (0.6); 5.7277 (0.6); 5.7249 (0.7); 5.7079 (0.6); 3.9950 (16.0); 3.9858 (12.2); 3.9226 (14.3); 1.7052 (0.9); 1.4620 (4.4); 1.4453 (4.4); 0.9009 (0.8); -0.0002 (3.8) I.2-211: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6223 (2.1); 8.6162 (3.1); 8.5951 (2.9); 8.5891 (1.9); 7.9371 (2.5); 7.9318 (2.6); 7.6967 (1.3); 7.6928 (2.3); 7.6887 (1.4); 7.6156 (2.2); 7.6104 (2.1); 7.5423 (1.4); 7.3695 (1.3); 7.2627 (9.0); 7.2427 (0.7); 5.6535 (0.6); 5.6364 (0.8); 5.6338 (0.8); 5.6167 (0.7); 4.1838 (16.0); 4.0357 (13.0); 3.7483 (0.8); 1.8544 (1.0); 1.5052 (5.0); 1.4884 (5.0); -0.0002 (10.0) I.2-212: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6116 (2.2); 8.6056 (2.8); 8.5666 (2.5); 8.5606 (2.0); 7.6692 (5.2); 7.6645 (5.4); 7.5999 (2.4); 7.5946 (2.6); 7.5006 (1.4); 7.4960 (2.5); 7.4912 (1.3); 7.4728 (2.2); 7.4676 (2.0); 7.2612 (21.7); 7.2436 (0.6); 7.2229 (0.6); 5.7375 (0.6); 5.7206 (0.7); 5.7174 (0.7); 5.7006 (0.6); 3.9942 (16.0); 3.9857 (12.8); 3.9220 (14.6); 1.5973 (2.9); 1.4519 (4.8); 1.4352 (4.8); 1.3036 (0.7); 1.2861 (0.9); 1.2644 (3.3); 0.8987 (1.7); 0.8820 (5.2); 0.8643 (2.1); 0.0079 (0.9); -0.0002 (26.5); -0.0084 (0.8) I.2-213: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6064 (2.2); 8.6004 (2.8); 8.5551 (2.4); 8.5490 (1.9); 7.9064 (2.1); 7.9013 (2.2); 7.6467 (1.0); 7.6415 (1.0); 7.6259 (1.4); 7.6207 (1.4); 7.6054 (2.4); 7.6001 (2.6); 7.5276 (2.6); 7.5068 (1.8); 7.4820 (2.0); 7.4767 (1.8); 7.2816 (0.5); 7.2691 (2.2); 7.2615 (0.5); 5.7436 (0.6); 5.7268 (0.6); 5.7238 (0.6); 5.7068 (0.6); 3.9925 (16.0); 3.9838 (11.8); 3.9193 (14.4); 1.4556 (4.3); 1.4389 (4.3); -0.0002 (2.5) I.2-214: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6159 (0.8); 8.6099 (1.0); 8.5670 (0.9); 8.5610 (0.7); 7.7055 (0.8); 7.7015 (0.5); 7.6019 (0.9); 7.5966 (1.0); 7.5598 (0.5); 7.4676 (0.8); 7.4624 (0.7); 7.2604 (25.0); 3.9949 (6.0); 3.9850 (4.7); 3.9226 (5.5); 1.5530 (16.0); 1.4611 (1.7); 1.4444 (1.7); 0.0079 (0.8); -0.0002 (29.3); -0.0085 (0.9) I.2-215: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6071 (3.4); 8.6031 (4.1); 8.5630 (3.6); 8.5590 (3.1); 7.8574 (7.3); 7.8546 (8.1); 7.8019 (2.2); 7.7990 (3.7); 7.7961 (1.8); 7.5955 (3.5); 7.5919 (3.7); 7.4723 (3.1); BCS241005-Abroad STR 240 7.4688 (2.9); 7.2604 (41.5); 7.2164 (0.9); 7.2031 (0.9); 5.7257 (0.9); 5.7144 (1.1); 5.7125 (1.0); 5.7012 (0.9); 5.2984 (13.9); 3.9927 (22.6); 3.9845 (18.2); 3.9210 (20.9); 2.0044 (2.4); 1.5814 (0.4); 1.5599 (50.0); 1.5414 (0.6); 1.4469 (6.9); 1.4357 (7.0); 1.2539 (0.4); 1.2152 (0.5); 1.2050 (0.5); 0.0053 (1.4); - 0.0001 (38.1); -0.0056 (1.3) I.2-216: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6284 (2.2); 8.6223 (2.7); 8.5738 (2.3); 8.5678 (1.9); 8.2472 (2.8); 8.0205 (1.2); 7.6154 (2.4); 7.6101 (2.5); 7.4825 (1.9); 7.4773 (1.8); 7.2614 (22.1); 5.7907 (0.5); 5.7737 (0.6); 5.7539 (0.5); 3.9999 (16.0); 3.9936 (11.9); 3.9279 (14.4); 1.5773 (5.0); 1.4927 (4.3); 1.4759 (4.3); 0.0079 (0.8); -0.0002 (27.2); -0.0085 (0.7) I.2-217: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6158 (2.2); 8.6098 (2.8); 8.5679 (2.3); 8.5618 (1.9); 7.8559 (1.2); 7.8520 (2.2); 7.8481 (1.3); 7.6019 (3.4); 7.5966 (3.1); 7.5274 (1.1); 7.4690 (1.9); 7.4637 (1.8); 7.2611 (31.4); 7.2469 (0.6); 5.7415 (0.5); 5.7246 (0.6); 5.7218 (0.6); 5.7048 (0.5); 3.9948 (16.0); 3.9849 (11.8); 3.9225 (14.5); 1.5675 (8.3); 1.4609 (4.2); 1.4442 (4.2); 0.0079 (1.0); -0.0002 (37.6); -0.0085 (1.2) I.2-223: 1H-NMR(400.6 MHz, CDCl3): δ= 8.5995 (1.6); 8.5898 (1.6); 8.5479 (1.2); 8.5421 (1.4); 8.5026 (1.4); 8.4968 (1.1); 8.2769 (1.2); 8.2605 (1.2); 8.1386 (0.8); 8.0200 (0.8); 7.9107 (0.6); 7.8949 (1.1); 7.8759 (0.7); 7.6972 (0.8); 7.6730 (1.7); 7.6544 (1.1); 7.6453 (1.3); 7.6265 (1.2); 7.6120 (1.4); 7.5945 (1.3); 7.5756 (0.5); 7.3793 (1.0); 7.3566 (1.1); 7.3486 (1.3); 7.3262 (1.3); 7.2605 (48.6); 5.3175 (1.0); 5.3000 (9.1); 4.0198 (0.9); 3.9758 (1.0); 3.9381 (6.4); 3.9255 (7.0); 3.8837 (1.0); 3.8402 (1.3); 3.7762 (8.0); 3.7671 (16.0); 3.3805 (1.0); 3.3705 (1.1); 3.3371 (0.9); 3.3267 (1.0); 2.9566 (5.3); 2.8844 (4.9); 2.1717 (0.8); 1.8532 (0.7); 1.7460 (6.1); 1.6667 (5.2); 1.5580 (8.1); 1.2535 (0.6); 0.7645 (1.4); 0.7461 (2.8); 0.7275 (1.3); 0.6935 (1.3); 0.6752 (2.5); 0.6566 (1.1); -0.0002 (60.8); -0.0083 (3.3) I.2-224: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6421 (1.0); 8.6361 (1.2); 8.5992 (1.2); 8.5932 (0.9); 8.4442 (0.8); 8.4241 (0.8); 8.3186 (0.9); 8.2829 (1.9); 8.1991 (0.5); 8.1794 (0.5); 7.9333 (0.5); 7.6468 (0.9); 7.4718 (0.9); 7.4494 (0.9); 7.2601 (38.9); 3.9525 (5.6); 3.7898 (11.3); 1.5400 (16.0); 0.8076 (1.1); 0.7892 (2.3); 0.7706 (1.0); -0.0002 (48.7); -0.0083 (2.6) I.2-225: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6461 (2.8); 8.6401 (3.5); 8.6021 (3.5); 8.5962 (2.7); 8.4875 (0.7); 8.3880 (2.3); 8.3689 (2.4); 8.3200 (3.0); 8.2813 (5.4); 8.2002 (1.5); 8.1805 (1.7); 8.0242 (0.8); 7.9610 (1.3); 7.9424 (1.6); 7.6684 (1.4); 7.6491 (2.5); 7.6295 (1.3); 7.4646 (2.5); 7.4426 (2.6); 7.2617 (63.2); 7.1209 (1.3); 7.0995 (1.4); 6.3870 (5.1); 5.5902 (1.0); 5.5719 (1.0); 5.5521 (0.5); 3.9527 (16.0); 3.7501 (0.5); 3.5751 (9.3); 2.9611 (5.2); 2.8883 (4.8); 1.8722 (1.0); 1.8556 (1.7); 1.8387 (1.5); 1.8208 (1.6); 1.8022 (1.6); 1.7844 (1.2); 1.7673 (0.8); 1.2534 (0.7); 0.8089 (3.1); 0.7904 (6.6); 0.7720 (2.9); - 0.0002 (78.0) BCS241005-Abroad STR 241 I.3-1: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5808 (1.5); 8.5744 (3.9); 8.5675 (4.1); 8.5611 (1.6); 8.1470 (1.2); 8.1443 (1.2); 8.1274 (1.3); 8.1246 (1.3); 7.7213 (0.6); 7.7180 (0.6); 7.7025 (1.4); 7.6992 (1.4); 7.6896 (1.5); 7.6853 (2.8); 7.6813 (2.2); 7.6071 (0.8); 7.6039 (0.9); 7.5878 (1.3); 7.5846 (1.4); 7.5687 (0.6); 7.5655 (0.6); 7.5441 (1.6); 7.4900 (1.2); 7.4711 (1.0); 7.4284 (0.6); 7.4091 (0.6); 7.3602 (1.5); 7.2609 (9.0); 5.2992 (0.7); 5.2811 (0.9); 5.2634 (0.7); 3.6571 (16.0); 1.3711 (6.0); 1.3543 (5.9); 1.2645 (1.6); 0.8987 (0.8); 0.8819 (2.5); 0.8643 (1.0); -0.0002 (12.7) I.3-2:1H-NMR (400.6 MHz, d6-DMSO3): δ= 12.7619 (0.9); 9.0751 (1.9); 9.0579 (1.9); 8.6062 (8.6); 10 8.5999 (10.1); 8.5357 (12.0); 8.5294 (10.4); 8.0050 (4.9); 8.0027 (3.3); 7.9857 (6.1); 7.9834 (4.0); 7.9781 (4.1); 7.9744 (6.0); 7.9706 (4.0); 7.9429 (0.6); 7.7817 (0.6); 7.7785 (0.6); 7.7758 (0.6); 7.7537 (5.5); 7.7512 (5.2); 7.7490 (5.0); 7.7465 (4.6); 7.7434 (5.1); 7.6493 (5.2); 7.6387 (8.2); 7.5921 (3.3); 7.5817 (2.1); 7.5728 (3.1); 7.5702 (2.3); 7.5618 (2.4); 7.5508 (1.9); 5.7577 (12.1); 5.1166 (1.8); 5.0995 (2.7); 5.0822 (1.8); 4.0387 (0.8); 4.0209 (0.8); 3.3225 (5.7); 2.6759 (0.7); 2.6714 (0.9); 2.6668 (0.7); 2.5251 (4.9); 2.5205 (6.0); 2.5117 (47.1); 2.5071 (97.1); 2.5025 (132.2); 2.4980 (91.0); 2.4934 (40.0); 2.3342 (0.6); 2.3296 (0.8); 2.3249 (0.5); 1.9894 (3.4); 1.9099 (1.2); 1.3570 (16.0); 1.3400 (13.6); 1.2700 (0.7); 1.2587 (0.6); 1.2340 (1.5); 1.1929 (1.4); 1.1818 (3.3); 1.1751 (2.7); 1.1701 (1.0); 1.1573 (1.2); 1.0740 (1.6); 1.0565 (3.2); 1.0390 (1.5); 0.8715 (0.6); 0.0080 (3.5); -0.0002 (104.6); -0.0085 (3.0) 20 I.3-3: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5711 (1.4); 8.5647 (4.1); 8.5590 (4.4); 8.5526 (1.5); 8.1498 (1.2); 8.1471 (1.2); 8.1303 (1.2); 8.1274 (1.2); 7.8896 (2.5); 7.8845 (2.6); 7.7184 (0.6); 7.7151 (0.6); 7.6996 (1.4); 7.6962 (1.4); 7.6808 (1.0); 7.6774 (0.9); 7.6300 (1.2); 7.6248 (1.1); 7.6092 (1.7); 7.6042 (2.2); 7.5857 (1.3); 7.5824 (1.4); 7.5666 (0.6); 7.5633 (0.6); 7.5167 (3.1); 7.4958 (3.2); 7.4762 (1.0); 7.4006 (0.6); 7.3809 (0.6); 7.2607 (14.0); 5.2967 (0.6); 5.2795 (0.8); 5.2609 (0.7); 3.6489 (16.0); 2.0455 (0.5); 1.3578 (5.9); 1.3410 (5.9); 0.0079 (0.6); -0.0002 (19.9); -0.0085 (0.6) I.3-4:1H-NMR (400.6 MHz, CDCl3): δ= 8.5810 (1.7); 8.5746 (3.5); 8.5631 (3.7); 8.5567 (1.8); 8.1483 (1.1); 8.1455 (1.1); 8.1287 (1.2); 8.1259 (1.2); 7.7190 (0.6); 7.7157 (0.6); 7.7002 (1.4); 7.6968 (1.4); 7.6813 (1.0); 7.6781 (0.9); 7.6503 (5.6); 7.6456 (5.8); 7.6060 (0.8); 7.6028 (0.9); 7.5867 (1.3); 7.5835 30 (1.4); 7.5677 (0.6); 7.5643 (0.6); 7.4840 (2.7); 7.4793 (3.1); 7.4746 (1.5); 7.4674 (1.0); 7.3822 (0.5); 7.3624 (0.6); 7.2605 (17.8); 5.2894 (0.7); 5.2722 (0.8); 5.2534 (0.7); 3.6575 (16.0); 2.0455 (0.7); 1.5647 (0.7); 1.3612 (5.9); 1.3445 (5.9); 1.2643 (1.0); 1.2597 (1.0); 0.8987 (0.5); 0.8820 (1.6); 0.8642 (0.7); 0.0079 (0.8); -0.0002 (25.3); -0.0085 (0.7) 35 I.3-5: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5908 (1.5); 8.5844 (3.8); 8.5768 (4.1); 8.5705 (1.6); 8.2182 (3.5); 8.1387 (1.2); 8.1359 (1.2); 8.1192 (1.3); 8.1163 (1.2); 8.0021 (1.6); 7.7305 (0.6); 7.7273 (0.6); 7.7118 (1.5); 7.7084 (1.4); 7.6929 (1.0); 7.6896 (0.9); 7.6117 (0.9); 7.6084 (0.9); 7.5924 (1.3); 7.5892 BCS241005-Foreign STR 242 (1.4); 7.5733 (0.6); 7.5700 (0.6); 7.5348 (0.6); 7.5187 (0.7); 7.4994 (1.2); 7.4806 (1.0); 7.2604 (29.5); 5.3518 (0.7); 5.3338 (0.9); 5.3159 (0.7); 3.6626 (16.0); 1.5556 (1.6); 1.4121 (5.8); 1.3954 (5.8); 0.0079 (1.4); -0.0002 (42.0); -0.0085 (1.1) 5 I.3-6: 1H-NMR (400.6 MHz, d6-DMSO): δ= 8.5978 (2.6); 8.5915 (3.0); 8.5264 (3.6); 8.5200 (3.1); 8.0787 (1.7); 8.0739 (1.7); 8.0024 (1.0); 7.9831 (1.1); 7.7957 (0.9); 7.7906 (0.8); 7.7748 (1.4); 7.7696 (1.4); 7.7221 (3.3); 7.7011 (2.0); 7.6567 (1.4); 7.6465 (2.1); 7.5943 (0.7); 7.5840 (0.6); 7.5748 (0.7); 7.5641 (0.6); 5.0975 (0.6); 5.0798 (0.9); 5.0627 (0.6); 4.0556 (0.8); 4.0378 (2.6); 4.0200 (2.6); 4.0023 (0.9); 3.3186 (16.0); 2.6745 (0.6); 2.6699 (0.8); 2.6653 (0.6); 2.5371 (0.8); 2.5324 (0.7); 2.5237 (2.2); 2.5190 (3.2); 2.5103 (46.3); 2.5057 (99.7); 2.5011 (137.9); 2.4966 (94.3); 2.4920 (41.3); 2.3328 (0.5); 2.3282 (0.8); 2.3236 (0.5); 1.9886 (11.9); 1.9084 (4.6); 1.3551 (1.0); 1.3423 (4.2); 1.3251 (4.1); 1.1922 (3.5); 1.1807 (1.1); 1.1744 (7.1); 1.1567 (3.4); 0.0080 (3.4); -0.0002 (126.8); -0.0060 (1.1); -0.0069 (1.0); -0.0085 (3.6) 15 I.3-7:1H-NMR (400.6 MHz, CDCl3): δ= 8.5906 (1.6); 8.5842 (3.9); 8.5766 (4.2); 8.5703 (1.7); 8.2178 (3.7); 8.1386 (1.2); 8.1358 (1.2); 8.1189 (1.3); 8.1161 (1.3); 8.0019 (1.6); 7.7304 (0.6); 7.7270 (0.6); 7.7115 (1.5); 7.7082 (1.5); 7.6927 (1.0); 7.6893 (0.9); 7.6114 (0.9); 7.6082 (1.0); 7.5921 (1.3); 7.5889 (1.4); 7.5730 (0.7); 7.5698 (0.7); 7.5359 (0.6); 7.5186 (0.7); 7.4996 (1.2); 7.4807 (1.0); 7.2605 (18.6); 5.3517 (0.7); 5.3335 (0.9); 5.3161 (0.7); 3.6626 (16.0); 1.5627 (0.6); 1.4121 (6.0); 1.3954 (5.9); 0.0079 20 (0.9); -0.0002 (22.5); -0.0085 (0.7) I.3-8: 1H-NMR(400.6 MHz, d6-DMSO): δ= 12.7626 (1.9); 9.3341 (2.6); 9.3171 (2.5); 8.6160 (8.8); 8.6097 (9.8); 8.5455 (11.3); 8.5392 (9.5); 8.4653 (13.1); 8.2935 (6.6); 8.0070 (5.3); 7.9877 (5.4); 7.6506 (7.7); 7.6391 (7.1); 7.6198 (1.1); 7.5890 (3.2); 7.5784 (2.5); 7.5696 (3.4); 7.5603 (1.8); 7.5477 (1.6); 25 6.8705 (0.6); 6.6265 (0.5); 5.1721 (2.0); 5.1546 (2.9); 5.1375 (1.9); 3.3206 (16.0); 2.6710 (1.7); 2.5110 (107.3); 2.5067 (196.5); 2.5022 (248.2); 2.4977 (171.6); 2.4934 (77.8); 2.3292 (1.4); 2.1839 (1.1); 1.9893 (0.7); 1.9094 (0.6); 1.3929 (15.3); 1.3756 (15.0); 1.3560 (8.2); 1.2694 (0.8); 1.2352 (1.1); 1.1814 (3.4); 1.1697 (1.2); 0.1458 (0.6); 0.0079 (8.2); -0.0002 (125.9); -0.0085 (4.6) 30 I.3-9: 1H-NMR(400.6 MHz, d6-DMSO): δ= 12.7653 (1.7); 9.3367 (2.6); 9.3198 (2.4); 8.6175 (6.6); 8.6115 (7.2); 8.5471 (7.8); 8.5413 (6.5); 8.4676 (12.1); 8.2936 (6.1); 8.0101 (4.5); 7.9906 (4.7); 7.6526 (7.2); 7.6412 (6.3); 7.6219 (1.4); 7.5906 (2.6); 7.5804 (2.4); 7.5704 (3.0); 7.5492 (1.3); 5.1752 (2.0); 5.1578 (2.7); 5.1410 (1.7); 4.0578 (1.6); 4.0397 (4.2); 4.0219 (4.0); 4.0043 (1.4); 3.6020 (0.5); 3.3255 (10.8); 2.6735 (1.9); 2.5075 (80.6); 2.5040 (93.0); 2.3324 (1.1); 2.1852 (0.7); 1.9903 (16.0); 1.760435 (0.5); 1.3955 (13.2); 1.3784 (12.4); 1.3582 (1.4); 1.2707 (0.6); 1.2343 (0.9); 1.1936 (4.8); 1.1758 (8.5); 1.1585 (4.2); -0.0002 (26.0) BCS241005-Abroad STR 243 I.3-10: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.5065 (0.8); 8.5002 (1.1); 8.4669 (1.6); 8.4606 (2.0); 8.2858 (0.5); 8.1131 (0.5); 7.7420 (0.7); 7.7286 (0.5); 5.2763 (1.5); 3.3209 (16.0); 2.5417 (0.5); 2.5247 (1.2); 2.5201 (1.4); 2.5113 (11.2); 2.5068 (22.8); 2.5022 (31.0); 2.4976 (21.4); 2.4931 (9.5); 2.0863 (5.4); 1.2648 (1.0); 1.2476 (1.0); -0.0002 (9.3) 5 I.3-11: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5934 (1.4); 8.5871 (4.0); 8.5808 (4.2); 8.5744 (1.5); 8.2212 (3.8); 8.1415 (1.2); 8.1390 (1.2); 8.1218 (1.3); 8.1188 (1.3); 8.0038 (1.7); 7.7336 (0.6); 7.7304 (0.6); 7.7148 (1.4); 7.7115 (1.5); 7.6960 (1.0); 7.6927 (1.0); 7.6146 (0.8); 7.6114 (1.0); 7.5952 (1.3); 7.5920 (1.4); 7.5762 (0.7); 7.5729 (0.7); 7.5499 (0.6); 7.5305 (0.6); 7.5018 (1.2); 7.4826 (1.0); 7.2618 (23.9); 5.3512 (0.7); 5.3332 (0.9); 5.3155 (0.7); 3.6648 (16.0); 2.1748 (1.6); 1.5801 (0.7); 1.4129 (6.0); 1.3962 (6.0); 1.2571 (0.6); 0.0080 (1.1); -0.0002 (34.6); -0.0085 (1.1) I.3-12:1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6491 (1.5); 8.6428 (1.7); 8.5648 (1.9); 8.5585 (1.7); 8.4652 (1.8); 8.3063 (0.9); 7.9993 (0.9); 7.9971 (0.5); 7.9799 (0.9); 7.7100 (1.2); 7.6996 (1.1); 7.6967 15 (0.8); 7.6274 (0.5); 5.1717 (0.5); 3.5237 (5.7); 3.3356 (16.0); 2.5214 (0.8); 2.5126 (10.1); 2.5081 (21.6); 2.5036 (29.7); 2.4990 (20.6); 2.4945 (9.1); 2.0872 (1.4); 1.3857 (2.2); 1.3684 (2.2); 0.0079 (0.8); - 0.0002 (23.9); -0.0085 (0.7) I.3-13: 1H-NMR (400.6 MHz, CDCl3): δ= 8.5635 (0.9); 8.5570 (4.5); 8.5543 (5.0); 8.5479 (1.0); 8.5161 20 (5.6); 8.1711 (1.1); 8.1684 (1.2); 8.1489 (1.8); 8.1278 (0.7); 7.7159 (0.5); 7.7125 (0.6); 7.7038 (0.7); 7.7007 (0.7); 7.6970 (1.4); 7.6936 (1.4); 7.6861 (0.7); 7.6829 (0.8); 7.6782 (1.0); 7.6747 (1.1); 7.6680 (0.8); 7.6044 (0.8); 7.6011 (1.0); 7.5970 (0.6); 7.5928 (0.5); 7.5851 (1.2); 7.5818 (1.4); 7.5659 (0.6); 7.5627 (0.7); 7.5508 (0.6); 7.5469 (0.6); 7.5390 (1.2); 7.5335 (1.1); 7.5286 (0.8); 7.5189 (1.1); 7.4725 (0.9); 7.4689 (0.9); 7.4544 (1.3); 7.4506 (1.3); 7.4024 (0.7); 7.3979 (0.7); 7.3900 (1.2); 7.3855 (1.4); 25 7.3785 (0.9); 7.3714 (1.0); 7.3671 (0.9); 7.3634 (0.6); 7.3538 (0.9); 7.3506 (1.0); 7.3325 (1.0); 7.2604 (33.0); 7.2183 (0.6); 7.1986 (0.6); 7.1245 (0.6); 7.1128 (1.3); 7.0940 (1.0); 5.3859 (1.0); 5.3690 (1.0); 5.3487 (0.7); 4.1309 (0.6); 4.1130 (0.6); 3.6857 (9.2); 3.6725 (16.0); 3.4584 (0.7); 3.4332 (0.8); 3.4109 (1.0); 2.1339 (1.0); 2.1148 (1.4); 2.1076 (1.3); 2.0884 (1.6); 2.0797 (0.6); 2.0606 (0.7); 2.0453 (2.6); 2.0168 (1.2); 1.9958 (1.5); 1.9815 (0.7); 1.9763 (0.9); 1.9605 (0.9); 1.5577 (2.8); 1.4779 (5.5); 1.4612 30 (5.5); 1.4161 (3.2); 1.3994 (3.2); 1.2772 (1.1); 1.2595 (2.2); 1.2416 (0.8); 0.8990 (0.6); 0.8820 (2.0); 0.8643 (0.8); 0.0080 (1.3); -0.0002 (46.7); -0.0084 (1.4) I.3-14: 1H-NMR(400.6 MHz, d6-DMSO): δ= 12.7565 (0.8); 9.0061 (0.7); 8.9894 (0.7); 8.6024 (4.0); 8.5961 (4.8); 8.5297 (5.8); 8.5233 (5.1); 8.0062 (1.6); 7.9869 (2.0); 7.8579 (0.5); 7.8531 (0.5); 7.8406 35 (6.0); 7.8358 (7.0); 7.7881 (3.3); 7.7834 (5.0); 7.7786 (2.3); 7.6604 (1.3); 7.6572 (1.4); 7.6419 (3.3); 7.5984 (1.4); 7.5921 (0.7); 7.5790 (1.4); 7.5723 (0.7); 7.5637 (0.6); 7.5571 (0.8); 5.0946 (0.8); 5.0777 (1.3); 5.0603 (0.8); 4.0556 (1.1); 4.0378 (3.4); 4.0200 (3.4); 4.0022 (1.1); 3.3183 (15.0); 2.6745 (0.8); BCS241005-Abroad STR 244 2.6699 (1.2); 2.6654 (0.9); 2.5400 (0.6); 2.5237 (2.7); 2.5191 (4.0); 2.5103 (67.0); 2.5057 (146.1); 2.5011 (203.9); 2.4965 (139.7); 2.4920 (61.1); 2.3328 (0.9); 2.3282 (1.2); 2.3235 (0.8); 2.0112 (0.5); 1.9886 (16.0); 1.3551 (1.4); 1.3441 (6.3); 1.3268 (6.3); 1.2343 (0.6); 1.1922 (4.7); 1.1807 (1.3); 1.1744 (9.7); 1.1566 (4.6); 0.8879 (0.5); 0.8711 (0.6); 0.1457 (0.6); 0.0118 (0.5); 0.0110 (0.7); 0.0102 (0.9); 0.0079 (5.8); 0.0063 (1.9); 0.0054 (2.1); 0.0046 (2.8); -0.0002 (191.3); -0.0043 (2.2); -0.0052 (1.5); -0.0060 (1.2); -0.0068 (1.1); -0.0085 (5.0); -0.1494 (0.6) The present invention further relates to the use of one or more compounds of the general formula (I) and/or their salts, as defined above, 10 preferably in one of the embodiments characterized as preferred or particularly preferred, in particular one or more compounds of formulas (I.1-1) to (I.3-18) and/or their salts, each as defined above, as a herbicide and/or plant growth regulator, preferably in crops of useful and/or ornamental plants. 15 The present invention further relates to a method for controlling pests and/or regulating plant growth, characterized in that an effective amount of - one or more compounds of the general formula (I) and/or their salts, as defined above, preferably in one of the embodiments characterized as preferred or particularly preferred, in particular one or more compounds of formulas (I.1-1) to (I.3-18) and/or their salts, each as defined above, or - an agent of the invention, as defined below, is applied to the (pest) plants, (pest) plant seeds, the soil in which or on which the (pest) plants 25 grow, or the cultivation area. The present invention also relates to a method for controlling unwanted plants, preferably in crops, characterized in that an effective amount 30 - of one or more compounds of the general formula (I) and/or their salts, as defined above, preferably in one of the embodiments characterized as preferred or particularly preferred, in particular one or more compounds of formulas (I.1-1) to (I.3-18) and/or their salts, each as defined above, or 35 - of an agent according to the invention, as defined below, BCS241005-Abroad STR 245 is applied to unwanted plants (e.g., pest plants such as mono- or dicotyledonous weeds or unwanted cultivated plants), the seed of the unwanted plants (i.e., plant seeds, e.g., grains, seeds, or vegetative propagation organs such as tubers or shoot parts with buds), the soil in which or on which the unwanted plants grow (e.g., the soil of cultivated land or non-cultivated land), or the cultivation area (i.e., the area on which the unwanted plants will grow). The present invention further relates to a method for combating and regulating the growth of plants, preferably crop plants, characterized in that an effective amount 10 - of one or more compounds of the general formula (I) and/or their salts, as defined above, preferably in one of the embodiments characterized as preferred or particularly preferred, in particular one or more compounds of formulas (I.1-1) to (I.3-18) and/or their salts, each as defined above, or 15 - of an agent according to the invention, as defined below, is applied to the plant, the seed of the plant (i.e. plant seeds, e.g. grains, seeds or vegetative propagating organs such as tubers or shoot parts with buds), the soil in which or on which the 20 plants grow (e.g. the soil of cultivated land or non-cultivated land) or the cultivation area (i.e. area on which the plants will grow). The compounds of general formula (I) or the agents according to the invention can be applied, for example, by pre-sowing (possibly also by incorporation into the soil), pre-emergence, and/or post-emergence application. By way of example, some representatives of the monocotyledonous and dicotyledonous weed flora that can be controlled by the compounds according to the invention are mentioned, without this mention implying a restriction to specific species. Preferably, in a method according to the invention for controlling weeds or for regulating plant growth, one or more compounds of general formula (I) and/or their salts are used to control weeds or to regulate growth in crops of useful or ornamental plants, wherein the useful or ornamental plants are, in a preferred embodiment, transgenic plants. The compounds of general formula (I) and/or their salts according to the invention are suitable for controlling the following genera of monocotyledonous and dicotyledonous weeds: BCS241005-Abroad STR 246 Monocotyledonous harmful plants of the genera: Aegilops, Agropyron, Agrostis, Alopecurus, Apera, Avena, Brachiaria, Bromus, Cenchrus, Commelina, Cynodon, Cyperus, Dactyloctenium, Digitaria, Echinochloa, Eleocharis, Eleusine, Eragrostis, Eriochloa, Festuca, Fimbristylis, Heteranthera, Imperata, Ischaemum, Leptochloa, Lolium, Monochoria, Panicum, Paspalum, Phalaris, Phleum, Poa, Rottboellia, Sagittaria, 5 Scirpus, Setaria, Sorghum. Dicotyledonous harmful plants of the genera: Abutilon, Amaranthus, Ambrosia, Anoda, Anthemis, Aphanes, Artemisia, Atriplex, Bellis, Bidens, Capsella, Carduus, Cassia, Centaurea, Chenopodium, Cirsium, Convolvulus, Datura, Desmodium, Emex, Erysimum, Euphorbia, Galeopsis, Galinsoga, Galium, Hibiscus, Ipomoea, Kochia, Lamium, Lepidium, Lindernia, Matricaria, Mentha, Mercurialis, Mullugo, 10 Myosotis, Papaver, Pharbitis, Plantago, Polygonum, Portulaca, Ranunculus, Raphanus, Rorippa, Rotala, Rumex, Salsola, Senecio, Sesbania, Sida, Sinapis, Solanum, Sonchus, Sphenoclea, Stellaria, Taraxacum, Thlaspi, Trifolium, Urtica, Veronica, Viola, Xanthium. If the compounds of general formula (I) according to the invention are applied to the soil surface before the germination of the 15 weeds (grasses and/or weeds) (pre-emergence method), either the emergence of the weed seedlings is completely prevented, or they grow to the cotyledon stage, but then cease growth and finally die completely after three to four weeks. 20 When the compounds of general formula (I) according to the invention are applied to the green parts of the plants in the post-emergence method, growth stops after treatment, and the weeds remain at the growth stage they were at the time of application or die completely after a certain period, so that in this way weed competition harmful to the cultivated plants is eliminated very early and sustainably. 25 Although the compounds of the general formula (I) according to the invention exhibit excellent herbicidal activity against mono- and dicotyledonous weeds, cultivated plants of economically important crops, e.g. dicotyledonous crops of the genera Arachis, Beta, Brassica, Cucumis, Cucurbita, Helianthus, Daucus, Glycine, Gossypium, Ipomoea, Lactuca, Linum, Lycopersicon, Miscanthus, Nicotiana, Phaseolus, Pisum, Solanum, Vicia, or monocotyledonous crops 30 of the genera Allium, Ananas, Asparagus, Avena, Hordeum, Oryza, Panicum, Saccharum, Secale, Sorghum, Triticale, Triticum, Zea, are only minimally damaged or not damaged at all, depending on the structure of the respective compound according to the invention and the amount applied. For these reasons, the present compounds are very well suited for the selective control of unwanted plant growth in crops such as agricultural crops or ornamental plantings. 35 Furthermore, the compounds of the general formula (I) according to the invention exhibit (depending on their respective structure and the application rate) excellent BCS241005-Abroad STR 247 exhibits growth-regulating properties in cultivated plants. It intervenes in the plant's own metabolism and can thus be used to selectively influence plant constituents and to facilitate harvesting, for example, by triggering desiccation and growth stunting. Furthermore, it is also suitable for the general control and inhibition of undesirable vegetative growth without killing the plants. Inhibition of vegetative growth plays a major role in many monocot and dicot crops, as it can, for example, reduce or completely prevent lodging. Due to their herbicidal and plant growth-regulating properties, the compounds of general formula (I) according to the invention can also be used to control weeds in crops of genetically modified or conventionally mutagenic plants. The transgenic plants are generally characterized by particularly advantageous properties, for example, resistance to certain pesticides, especially certain herbicides, resistance to plant diseases or pathogens of plant diseases such as certain insects or microorganisms such as fungi, bacteria, or viruses. Other special properties relate, for example, to the harvested crop with regard to quantity, quality, storability, composition, and specific constituents. Thus, transgenic plants with increased starch content or altered starch quality, or those with a different fatty acid composition of the harvested crop, are known. The application of the compounds of the invention of general formula (I) and/or their salts in economically important transgenic crops of useful and ornamental plants is preferred with regard to transgenic crops, e.g., cereals such as wheat, barley, rye, oats, millet, rice, and maize, or also crops of sugar beet, cotton, soybean, rapeseed, potato, tomato, pea, and other vegetables. Preferably, the compounds of general formula (I) according to the invention can also be used as herbicides in crops that are resistant to the phytotoxic effects of the herbicides or have been genetically engineered to be resistant. 30 Due to their herbicidal and plant growth-regulating properties, the compounds of general formula (I) according to the invention can also be used to control weeds in crops of known or yet-to-be-developed genetically modified plants. The transgenic plants are generally characterized by particularly advantageous properties 35, for example, by resistance to certain pesticides, especially certain herbicides, resistance to plant diseases or pathogens of plant diseases such as certain insects or microorganisms such as fungi, bacteria, or viruses. Other special BCS241005-Abroad STR 248 Properties relate, for example, to the harvested crop with regard to quantity, quality, storability, composition, and specific constituents. For instance, transgenic plants with increased starch content or altered starch quality, or those with a different fatty acid composition of the harvested crop, are known. Further special properties may include tolerance or resistance to abiotic stressors such as heat, cold, drought, salt, and ultraviolet radiation. The application of the compounds of general formula (I) or their salts according to the invention is preferred in economically important transgenic crops of useful and ornamental plants, e.g., cereals such as wheat, barley, rye, oats, triticale, millet, rice, cassava, and maize, or also crops of sugar beet, cotton, soybean, rapeseed, potato, tomato, pea, and other vegetables. Preferably, the compounds of general formula (I) can be used as herbicides in crops that are resistant to the phytotoxic effects of the herbicides or have been genetically engineered to be resistant. 15 Conventional methods for producing new plants that exhibit modified properties compared to existing plants include, for example, classical breeding methods and the generation of mutants. Alternatively, new plants with altered properties can be produced using genetic engineering techniques. 20 Numerous molecular biological techniques for producing new transgenic plants with altered properties are known to those skilled in the art. For such genetic engineering manipulations, nucleic acid molecules can be introduced into plasmids, which allow mutagenesis or sequence modification by recombination of DNA sequences. Using 25 standard methods, for example, base exchanges can be carried out, partial sequences removed, or natural or synthetic sequences added. Adaptors or linkers can be attached to the DNA fragments to join them together. The production of plant cells with reduced activity of a gene product can be achieved, for example, by expressing at least one corresponding antisense RNA, a sense RNA to achieve a cosuppression effect, or the expression of at least one appropriately engineered ribozyme that specifically cleaves transcripts of the aforementioned gene product. For this purpose, DNA molecules can be used that comprise the entire coding sequence of a gene product, including any flanking sequences, as well as DNA molecules that comprise only parts of the coding sequence, provided these parts are long enough, BCS241005-Abroad STR 249 to induce an antisense effect in the cells. It is also possible to use DNA sequences that exhibit a high degree of homology to the coding sequences of a gene product, but are not completely identical. 5 When nucleic acid molecules are expressed in plants, the synthesized protein can be localized in any compartment of the plant cell. However, to achieve localization in a specific compartment, the coding region can, for example, be linked to DNA sequences that ensure localization in a particular compartment. Such sequences are known to those skilled in the art (see, for example, Braun et al., EMBO J. 11 (1992), 3219-3227). The expression of the nucleic acid molecules can also take place in the organelles of the plant cells. The transgenic plant cells can be regenerated into whole plants using known techniques. In principle, transgenic plants can be from any of the 15 plant species, i.e., both monocotyledonous and dicotyledonous plants. Thus, transgenic plants are available that exhibit altered characteristics through overexpression, suppression, or inhibition of homologous (= natural) genes or gene sequences, or expression of heterologous (= foreign) genes or gene sequences. 20 Preferably, the compounds of general formula (I) according to the invention can be used in transgenic cultures which are resistant to growth regulators, such as dicamba, or to herbicides that inhibit essential plant enzymes, e.g. acetolactate synthases (ALS), EPSP synthases, glutamine synthases (GS) or hydroxyphenylpyruvate dioxygenases (HPPD), respectively, or to herbicides from the 25 group of sulfonylureas, glyphosates, glufosinates or benzoylisoxazoles and analogous active substances. When the compounds of general formula (I) according to the invention are applied in transgenic crops, in addition to the effects observed in other crops against weeds, 30 effects often occur that are specific to the application in the respective transgenic crop, for example, an altered or specifically expanded weed spectrum that can be controlled, altered application rates that can be used, preferably good compatibility with the herbicides to which the transgenic crop is resistant, as well as influencing the growth and yield of the transgenic crop plants. 35 ... BCS241005-Abroad STR 250 The invention therefore also relates to the use of the compounds of general formula (I) and/or their salts as herbicides for controlling weeds in crops of useful or ornamental plants, optionally in transgenic crops. 5 Use in cereals, preferably maize, wheat, barley, rye, oats, millet, or rice, pre- or post-emergence, is preferred. Use in soybeans pre- or post-emergence is also preferred. 10 The use according to the invention for controlling weeds or for regulating plant growth also includes the case in which a compound of general formula (I) or its salt is formed from a precursor substance ("prodrug") only after application to the plant, in the plant, or in the soil. 15 The invention also relates to the use of one or more compounds of the general formula (I) or their salts or of an agent according to the invention (as defined below) (in a method) for controlling pests or for regulating plant growth, characterized in that an effective amount of one or more compounds of the general formula (I) or their salts is applied to the plants (pests, optionally together with the 20 crop plants), plant seeds, the soil in which or on which the plants grow, or the cultivation area. The invention also relates to a herbicidal and/or plant growth regulator, characterized in that the agent 25 (a) contains one or more compounds of general formula (I) and/or their salts as defined above, preferably in one of the embodiments characterized as preferred or particularly preferred, in particular one or more compounds of formulas (I.1-1) to (I.3-18) and/or their salts, each as defined above, 30 and (b) one or more further substances selected from groups (i) and/or (ii): (i) one or more further agrochemically active substances, preferably selected from the group 35 consisting of insecticides, acaricides, nematicides, further herbicides (i.e., those not corresponding to general formula (I) defined above), fungicides, safeners, fertilizers and/or further growth regulators, BCS241005-Abroad STR 251 (ii) one or more formulation aids commonly used in plant protection. The further agrochemical active substances of component (i) of a composition 5 according to the invention are preferably selected from the group of substances listed in "The Pesticide Manual", 16th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2012. A herbicidal or plant growth regulator according to the invention preferably comprises one, two, three or more formulation aids (ii) commonly used in plant protection, selected from the group consisting of surfactants, emulsifiers, dispersants, film formers, thickeners, inorganic salts, dusting agents, carriers solid at 25 °C and 1013 mbar, preferably adsorbable, granulated inert materials, wetting agents, antioxidants, stabilizers, buffer substances, antifoaming agents, water, organic solvents, preferably organic solvents miscible with water in any desired ratio at 25 °C and 1013 mbar. The compounds according to the invention of general formula (I) can be used in the form of sprayable powders, emulsifiable concentrates, sprayable solutions, dusting agents or granules in conventional preparations. The invention therefore also relates to herbicidal and plant growth regulators containing compounds of general formula (I) and/or their 20 salts. The compounds of general formula (I) and/or their salts according to the invention can be formulated in various ways, depending on which biological and/or physicochemical parameters are specified. Possible formulations include, for example: 25 spray powders (WP), water-soluble powders (SP), water-soluble concentrates, emulsifiable concentrates (EC), emulsions (EW) such as oil-in-water and water-in-oil emulsions, sprayable solutions, suspension concentrates (SC), oil- or water-based dispersions, oil-miscible solutions, capsule suspensions (CS), dusting agents (DP), pickling agents, granules for broadcast and ground application, granules (GR) in the form of micro-, spray-, lift- and adsorption granules, 30 water-dispersible granules (WG), water-soluble granules (SG), ULV formulations, microcapsules and waxes. These individual formulation types and formulation aids such as inert materials, surfactants, solvents, and other additives are known to those skilled in the art and are described, for example, in: Watkins, "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Darland 35 Books, Caldwell NJ; H.v. Olphen, "Introduction to Clay Colloid Chemistry"; 2nd Ed., J. Wiley & Sons, N.Y.; C. Marsden, "Solvents Guide"; 2nd Ed., Interscience, N.Y. 1963; McCutcheon's "Detergents and Emulsifiers Annual", MC Publ. Corp., Ridgewood NJ; Sisley and Wood, "Encyclopedia of Surface BCS241005-Ausland STR 252 Active Agents", Chem. Publ. Co. Inc., N.Y. 1964; Schönfeldt, "Interfacially Active Ethylene Oxide Adducts", Wiss. Verlagsgesellschaft, Stuttgart 1976; Winnacker-Küchler, "Chemical Technology", Volume 7, C. Hanser Verlag Munich, 4th ed. 1986. 5 Spray powders are preparations that are uniformly dispersible in water and, in addition to the active ingredient, contain surfactants of ionic and/or non-ionic nature (wetting agents, dispersing agents), e.g., polyoxyethylated alkylphenols, polyoxyethylated fatty alcohols, polyoxyethylated fatty amines, fatty alcohol polyglycol ether sulfates, alkanesulfonates, alkylbenzenesulfonates, sodium ligninsulfonic acid, 2,2'-dinaphthylmethane-6,6'-disulfonic acid sodium, The herbicidal active ingredients are found in dibutylnaphthalenesulfonic acid sodium 10 or oleoylmethyltauric acid sodium. To produce the spray powders, the herbicidal active ingredients are finely ground in conventional equipment such as hammer mills, blower mills, and air jet mills and simultaneously or subsequently mixed with the formulation aids. Emulsifiable concentrates are produced by dissolving the active ingredient in an organic solvent, e.g., butanol, cyclohexanone, dimethylformamide, xylene, or higher-boiling aromatics or hydrocarbons, or mixtures of organic solvents, with the addition of one or more ionic and/or non-ionic surfactants (emulsifiers). Examples of emulsifiers include: calcium alkylarylsulfonic acid salts such as calcium dodecylbenzenesulfonate 20, or non-ionic emulsifiers such as fatty acid polyglycol esters, alkylaryl polyglycol ethers, fatty alcohol polyglycol ethers, and propylene oxide-ethylene oxide condensation products. Alkyl polyethers, sorbitan esters such as sorbitan fatty acid esters, or polyoxyethylene sorbitan esters such as polyoxyethylene sorbitan fatty acid esters. 25 Dusts are obtained by grinding the active ingredient with finely divided solids, e.g., talc, natural clays such as kaolin, bentonite, and pyrophyllite, or diatomaceous earth. Suspension concentrates can be water- or oil-based. They can be produced, for example, by wet milling using commercially available bead mills and, if necessary, the addition of surfactants, such as those already listed above under the other formulation types. 30 Emulsions, e.g., oil-in-water emulsions (EW), can be produced, for example, using stirrers, colloid mills, and/or static mixers with aqueous organic solvents and, if necessary, surfactants, such as those already listed above under the other formulation types. 35 Granules can be produced either by The active ingredient can be atomized onto adsorbable, granulated inert material or applied by means of adhesives. These products are manufactured by atomizing the active ingredient onto adsorbable, granulated inert material or by applying active ingredient concentrates using adhesives. BCS241005-Abroad STR 253, e.g., polyvinyl alcohol, sodium polyacrylate, or mineral oils, are applied to the surface of carrier materials such as sand, kaolinite, or granulated inert material. Suitable active ingredients can also be granulated in the manner customary for the production of fertilizer granules—optionally in mixture with fertilizers. Water-dispersible granules are generally produced using standard methods such as spray drying, fluidized bed granulation, disc granulation, mixing with high-speed mixers, and extrusion without solid inert material. For the production of disc, fluidized bed, extruder, and spray granules, see, for example, the processes in "Spray-Drying Handbook," 3rd ed. 1979, G. Goodwin Ltd., London; J.E. Browning, "Agglomeration," Chemical and Engineering 1967, pages 147 ff. "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, New York 1973, pp. 8-57. 15 For further details on the formulation of plant protection products, see, for example, G.C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc., New York, 1961, pages 81-96 and J.D. Freyer, S.A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, pages 101-103. 20 The agrochemical preparations, preferably herbicidal or plant growth regulators of the present invention, preferably contain a total amount of 0.1 to 99 wt.%, more preferably 0.5 to 95 wt.%, further preferably 1 to 90 wt.%, and particularly preferably 2 to 80 wt.%, of active ingredients of general formula (I) and their salts. 25 In sprayable powders, the active ingredient concentration is, for example, about 10 to 90 wt.%, the remainder to 100 wt.% consisting of usual formulation components. In emulsifiable concentrates, the active ingredient concentration can be about 1 to 90 wt.%, preferably 5 to 80 wt.%. Powder formulations contain 1 to 30 wt.% active ingredient, preferably mostly 5 to 20 wt.% active ingredient; sprayable solutions contain about 0.05 to 80 wt.%, preferably 2 to 50 wt.% active ingredient. 30 In water-dispersible granules, the active ingredient content depends partly on whether the active compound is liquid or solid and which granulation aids, fillers, etc., are used. In water-dispersible granules, the active ingredient content is, for example, between 1 and 95 wt.%, preferably between 10 and 80 wt.%. 35 In addition, the aforementioned active ingredient formulations may contain the usual adhesives, wetting agents, dispersants, emulsifiers, penetrating agents, preservatives, antifreeze agents and solvents, fillers, carriers and colorants, defoamers, evaporation inhibitors and the pH value and viscosity. BCS241005-Abroad STR 254 influencing agents. Examples of formulation aids are described, among others, in "Chemistry and Technology of Agrochemical Formulations", ed. D. A. Knowles, Kluwer Academic Publishers (1998). 5 The compounds of general formula (I) according to the invention or their salts can be used as such or in the form of their preparations (formulations) in combination with other pesticides, such as insecticides, acaricides, nematicides, herbicides, fungicides, safeners, fertilizers and/or growth regulators, e.g. as finished formulations or as tank mixes. The combination formulations can be prepared on the basis of the above-mentioned 10 formulations, taking into account the physical properties and stabilities of the active ingredients to be combined. For example, known active ingredients based on the inhibition of, for example, acetolactate synthase, acetyl-CoA carboxylase, cellulose synthase, enolpyruvylshikimate-3-phosphate synthase, glutamine synthetase, p-hydroxyphenylpyruvate dioxygenase, phytoendesaturase, photosystem I, photosystem II, and protoporphyrinogen oxidase can be used as combination partners for the compounds of general formula (I) according to the invention in mixture formulations or in tank mixes. These include, for example, known active ingredients based on the inhibition of, for example, acetolactate synthase, acetyl-CoA carboxylase, cellulose synthase, enolpyruvylshikimate-3-phosphate synthase, glutamine synthase, p-hydroxyphenylpyruvate dioxygenase, phytoendesaturase, photosystem I, photosystem II, and protoporphyrinogen oxidase, as described, for example, in Weed Research 26 (1986) 441-445 or "The Pesticide Manual", 16th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2012, and the literature cited therein. The selective control of weeds in crops of useful and ornamental plants is of particular interest. Although the compounds of general formula (I) according to the invention already exhibit very good to sufficient selectivity in many crops, phytotoxicity can, in principle, occur in some crops, and especially in the case of mixtures with other herbicides that are less selective. In this respect, combinations of compounds of general formula (I) according to the invention are of particular interest, which contain the compounds (I) or their combinations with other herbicides or pesticides and safeners. The safeners, which are used in an antidotally effective concentration, reduce the phytotoxic side effects of the herbicides/pesticides used, e.g., in economically important crops such as cereals (wheat, barley, rye, maize, rice, millet), sugar beet, sugar cane, rapeseed, cotton, and soybeans, preferably cereals. The weight ratio of herbicide (mixture) to safener generally depends on the application rate of herbicide and the efficacy of the respective safener and can vary within wide limits, for example in the range of 200:1 to 1:200, preferably 100:1 to 1:100, particularly 20:1 to 1:20. The safeners can be formulated analogously to the compounds of general formula (I) BCS241005-Abroad STR 255 or mixtures thereof with other herbicides/pesticides are formulated and provided and applied as a ready-to-use formulation or tank mix with the herbicides. For application, the commercially available herbicide or herbicide-safener formulations are optionally diluted in the usual manner, e.g., in the case of spray powders, emulsifiable concentrates, dispersions, and water-dispersible granules, by means of water. Powdery preparations, soil or granular coatings, and sprayable solutions are not usually diluted with further inert substances before application. External conditions such as temperature, humidity, etc., influence to a certain extent the application rate of the compounds of general formula (I) and/or their salts according to the invention. The application rate can vary within wide limits. For use as a herbicide to control weeds, the total amount of the compounds of general formula (I) and their salts according to the invention is preferably in the range of 0.001 to 10.0–15 kg/ha, more preferably in the range of 0.005 to 5 kg/ha, further preferably in the range of 0.01 to 1.5 kg/ha, and particularly preferably in the range of 0.05 to 1 kg/ha. This applies to both pre-emergence and post-emergence application. When using compounds of general formula (I) and/or their 20 salts according to the invention as plant growth regulators, for example as stem shorteners in crops such as those mentioned above, preferably in cereal crops such as wheat, barley, rye, triticale, millet, rice, or maize, the total application rate is preferably in the range of 0.001 to 2 kg/ha, more preferably in the range of 0.005 to 1 kg/ha, particularly in the range of 10 to 500 g/ha, and most preferably in the range of 20 to 250 g/ha. This applies to both pre-emergence and post-emergence application. Application as a stem shortener can take place at various stages of plant growth. For example, application after tillering at the beginning of stem elongation is preferred. 30 Alternatively, when used as a plant growth regulator, seed treatment is also an option, which includes various seed dressing and coating techniques. The application rate depends on the specific technique and can be determined in preliminary trials. 35 For example, known active ingredients based on the inhibition of, for example, are suitable combination partners for the compounds of general formula (I) in mixture formulations or in tank mixes. BCS241005-Abroad STR 256 Acetolactate synthase, acetyl-CoA carboxylase, cellulose synthase, enolpyruvylshikimate-3-phosphate synthase, glutamine synthetase, p-hydroxyphenylpyruvate dioxygenase, phytoendesaturase, photosystem I, photosystem II, protoporphyrinogen oxidase are based on or act as plant growth regulators, as described, for example, in Weed Research 26 (1986) 441-445 or 5 "The Pesticide Manual", 19th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2021 and the literature cited therein. Examples of well-known herbicides or plant growth regulators that can be combined with compounds of the general formula (I) include the following active substances (the compounds are designated either by the "common name" according to the International Organization for Standardization (ISO) or by the chemical name or by the code number) and always include all application forms such as acids, salts, esters and isomers such as stereoisomers and optical isomers. Examples of applications include: Acetochlor, Acifluorfen, Acifluorfen-methyl, Acifluorfen-sodium, Aclonifen, Alachlor, Allidochlor, 15-Alloxydim, Alloxydim-sodium, Ametryn, Amicarbazone, Amidochlor, Amidosulfuron, 4-Amino-3-chloro-6-(4-chloro-2-fluoro-3-methylphenyl)-5-fluoropyridine-2-carboxylic acid, Aminocyclopyrachlor, Aminocyclopyrachlor-potassium, Aminocyclopyrachlor-methyl, Aminopyralid, Aminopyralid-dimethylammonium, Aminopyralid-tripromine, Amitrole, Ammonium sulfamates, Anilofos, Asulam, Asulam-potassium, Asulam-sodium, Atrazine, Azafenidine, Azimsulfuron, Beflubutamide (S); Bilanafos, Bilanafos sodium, Bipyrazone, Bispyribac, Bispyribac sodium, Bixlozone, Bromacil, Bromacil-lithium, Bromacil sodium, Bromobutide, Bromofenoxime, Bromoxynil, Bromoxynil butyrate, Bromoxynil potassium, Bromoxynil-25 heptanoate and Bromoxynil octanoate, Busoxinone, Butachlor, Butafenacil, Butamifos, Butenachlor, Butralin, Butroxydim, Butylate, Cafenstrol, Cambendichlor, Carbetamide, Carfentrazone, Carfentrazone-Ethyl, Chloramben, Chloramben-ammonium, Chloramben-diolamine, Chroamben-methyl, Chloramben-methylammonium, Chloramben-sodium, Chlorbromuron, Chlorfenac, Chlorfenac-ammonium, Chlorfenac-sodium, Chlorfenprop, Chlorfenprop-methyl, Chlorflurenol, Chlorflurenol-methyl, 30 Chloridazon, Chlorimuron, Chlorimuron-ethyl, Chlorophthalim, Chlorotoluron, Chlorsulfuron, Chlorthal, Chlorthal-dimethyl, Chlorthal-monomethyl, Cinflubroline, Cinidon, Cinidon-ethyl, Cinmethylin, exo-(+)-Cinmethylin, i.e. (1R,2S,4S)-4-isopropyl-1-methyl-2-[(2-methylbenzyl)oxy]-7-oxabicyclo[2.2.1]heptane, exo-(-)-cinmethyline, i.e. (1R,2S,4S)-4-isopropyl-1-methyl-2-[(2- methylbenzyl)oxy]-7-oxabicyclo[2.2.1]heptane, Cinosulfuron, Clacyfos, Clethodim, Clodinafop, 35 Clodinafop-ethyl, Clodinafop-propargyl, Clomazone, Clomeprop, Clopyralid, Clopyralid-methyl, Clopyralid-olamine, Clopyralid-potassium, Clopyralid-tripomin, Cloransulam, Cloransulam-methyl, Cumyluron, Cyanamide, Cyanazine, Cycloate, Cyclopyranil, Cyclopyrimorate, Cyclosulfamuron, BCS241005-Abroad STR 257 Cycloxydim, cyhalofop, cyhalofop-butyl, cyprazine, 2,4-D (as well as ammonium, butotyl, butyl, choline, diethylammonium, dimethylammonium, diolamine, doboxyl, dodecylammonium, etexyl, ethyl, 2-ethylhexyl, heptylammonium, Isobutyl, isooctyl, isopropyl, isopropylammonium, lithium, meptyl, methyl, potassium, tetradecyl ammonium, triethylammonium, triisopropanolammonium, 5 tripromine and trolamine salts thereof), 2,4-DB, 2,4-DB-butyl, 2,4-DB-dimethylammonium, 2,4-DB-isooctyl, 2,4-DB potassium and 2,4-DB sodium, daimuron (Dymron), dalapon, dalapon calcium, Dalapon magnesium, dalapon sodium, dazomet, dazomet sodium, n-decanol, 7-deoxy-D-sedoheptulose, desmedipham, detosyl pyrazolate (DTP), dicamba and its salts (e.g. dicamba biproamine, dicamba-N,N-bis(3-aminopropyl)methylamine, Dicamba butotyl, Dicamba choline, Dicamba-10 diglycolamine, Dicamba dimethylammonium, Dicamba diethanolaminemmonium, Dicamba diethylammonium, Dicamba isopropylammonium, Dicamba methyl, Dicamba monoethanolamine, Dicamba olamine, Dicamba potassium, Dicamba sodium, Dicamba triethanolamine), Dichlobenil, 2-(2.4- Dichlorobenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one, 2-(2,5-dichlorobenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one, dichlorprop, dichlorprop-butotyl, dichlorprop-dimethylammonium, dichlorprop-etexyl, 15 dichlorprop-ethylammonium, dichlorprop-isoctyl, Dichlorprop-methyl, dichlorprop-potassium, dichlorprop-sodium, dichlorprop-P, dichlorprop-P-dimethylammonium, dichlorprop-P-etexyl, dichlorprop-P-potassium, dichlorprop-sodium, diclofop, diclofop-methyl, diclofop-P, diclofop-P-methyl, diclosulam, difenzoquat, difenzoquat-metilsulfate, diflufenican, diflufenzopyr, diflufenzopyr sodium, Dimefuron, Dimepiperate, Dimesulfazet, Dimethachlor, Dimethametryn, 20 Dimethenamid, Dimethenamid-P, Dimetrasulfuron, Dinitramine, Dinoterb, Dinoterb-Acetate, Diphenamide, Diquat, Diquat-Dibromide, Diquat-Dichlorid, Dithiopyr, Diuron, DNOC, DNOC-Ammonium, DNOC potassium, DNOC sodium, endothal, endothal diammonium, endothal dipotassium, endothal disodium, epyrifenacil, EPTC, esprocarb, ethalfluralin, ethametsulfuron, ethametsulfuron-methyl, ethiozin, ethofumesate, ethoxyfen, ethoxyfen-ethyl, ethoxysulfuron, Etobenzanide, F-5231,25 i.e. N-[2-Chloro-4-fluoro-5-[4-(3-fluoropropyl)-4,5-dihydro-5-oxo-1H-tetrazol-1-yl]-phenyl]-ethanesulfonamide, F-7967, i.e.3-[7-Chloro-5-fluoro-2-(trifluoromethyl)-1H-benzimidazol-4-yl]-1-methyl-6- (trifluoromethyl)pyrimidine-2,4(1H,3H)-dione, Fenoxaprop, Fenoxaprop-P, Fenoxaprop-Ethyl, Fenoxaprop-P-Ethyl, Fenoxasulfone, Fenpyrazone, Fenquinotrione, Fentrazamide, Flamprop, Flamprop-Isoproyl, Flamprop-Methyl, Flamprop-M-Isopropyl, Flamprop-M-Methyl, Flazasulfuron, Florasulam, 30 Florpyrauxifen, Florpyrauxifen-benzyl, Fluazifop, Fluazifop-butyl, Fluazifop-methyl, Fluazifop-P, Fluazifop-P-butyl, Flucarbazone, Flucarbazone-sodium, Flucetosulfuron, Fluchloralin, Flufenacet, Flufenpyr, Flufenpyr-ethyl, Flumetsulam, Flumiclorac, Flumiclorac-pentyl, Flumioxazine, Fluometuron, Flurenol, Flurenol-butyl, -dimethylammonium and -methyl, Fluoroglycofen, Fluoroglycofen-ethyl, Flupropanate, Flupropanate-sodium, Flupyrsulfuron, Flupyrsulfuron-methyl, Flupyrsulfuron-methyl-35 sodium, Fluridon, Flurochloridone, Fluroxypyr Fluroxypyr-Butometyl, Fluroxypyr-Meptyl, Flurtamon, Fluthiacet, Fluthiacet-Methyl, Fomesafen, Fomesafen Sodium, Foramsulfuron, Foramsulfuron Sodium, Fosamine, Fosamine Ammonium, Glufosinate, Glufosinate Ammonium, Glufosinate Sodium, L- BCS241005-Abroad STR 258 Glufosinate ammonium, L-glufosinate sodium, glufosinate P-sodium, glufosinate P-ammonium, glyphosate, glyphosate ammonium, glyphosate isopropyl ammonium, glyphosate diammonium, glyphosate dimethyl ammonium, glyphosate potassium, Glyphosate sodium, glyphosate sesquinodium and glyphosate trimesium, H-9201, i.e. O-(2,4-dimethyl-6-nitrophenyl)-O-ethyl-5 isopropylphosphoramidothioate, Halauxifen, Halauxifen-methyl, Halosafen, Halosulfuron, Halosulfuron-Methyl, Haloxyfop, Haloxyfop-P, Haloxyfop-Ethoxyethyl, Haloxyfop-P-Ethoxyethyl, Haloxyfop-Methyl, Haloxyfop-P-Methyl, Haloxifop Sodium, Hexazinone, HNPC-A8169, i.e. Prop-2-yn-1-yl (2S)- 2-{3-[(5-tert-butylpyridin-2-yl)oxy]phenoxy}propanoate, HW-02, i.e. 1-(Dimethoxyphosphoryl)-ethyl-(2,4-dichlorophenoxy)acetate, Hydantocidin, Icafolin, Icafolin-Methyl, Imazamethabenz, 10 Imazamethabenz-Methyl, Imazamox, Imazamox-Ammonium, Imazapic, Imazapic-Ammonium, Imazapyr, Imazapyr-isopropylammonium, Imazaquin, Imazaquin-ammonium, Imazaquin-methyl, Imazethapyr, Imazethapyr-ammonium, Imazosulfuron, Indanofan, Indaziflam, Indolauxipyr, Iodosulfuron, Iodosulfuron-Methyl, Iodosulfuron-Methyl-Sodium, Ioxynil, Ioxynil-Lithium, -Octanoate, -Potassium and Sodium, Ipfencarbazone, Iptriazopyrid, i.e. 3-[(Isopropylsulfonyl)methyl]-N-(5-methyl-15 1,3,4-oxadiazol-2-yl)-5-(trifluoromethyl)[1,2,4]triazolo-[4,3-a]pyridine-8-carboxamide, Isoproturon, Isouron, Isoxaben, Isoxaflutole, Carbutilate, KUH-043, i.e. 3-({[5-(difluoromethyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}sulfonyl)-5,5-dimethyl-4,5-dihydro-1,2-oxazole, Ketospiradox, Ketospiradox-potassium, Lactofen, Lenacil, Linuron, MCPA, MCPA-Butotyl, -Butyl, -Dimethyl- ammonium, -diolamine, -2-ethylhexyl, -ethyl, -isobutyl, isoctyl, -isopropyl, -isopropylammonium, -20 methyl, olamine, -potassium, -sodium and -trolamine, MCPB, MCPB-methyl, -ethyl and -sodium, mecoprop, mecoprop-butotyl, mecoprop-dimethylammonium, Mecoprop-Diolamin, Mecoprop-Etexyl, Mecoprop-Ethadyl, Mecoprop-isoctyl, mecoprop-methyl, mecoprop potassium, mecoprop sodium, and mecoprop trolamine, mecoprop-P, mecoprop-P-butotyl, -dimethylammonium, -2-ethylhexyl and -potassium, mefenacet, mefluidide, mefluidide-diolamine, mefluidide-potassium, mesosulfuron, Mesosulfuron- 25 Methyl, Mesosulfuron Sodium, Mesotrione, Methabenzthiazuron, Metam, Metamifop, Metamitron, Metazachlor, Metazosulfuron, Methabenzthiazuron, Methiopyrsulfuron, Methiozoline, Methyl isothiocyanate, Metobromuron, Metolachlor, S-Metolachlor, Metosulam, Metoxuron, metproxybicyclon, metribuzin, metsulfuron, Metsulfuron-Methyl, Molinate, Monolinuron, Monosulfuron, Monosulfuron-Methyl, MT-5950, i.e. N-[3-Chloro-4-(1-methylethyl)-phenyl]-2-methylpentanamide, NGGC-011, 30 Napropamide, NC-310, i.e.4-(2,4-Dichlorobenzoyl)-1-methyl-5-benzyloxypyrazole, Neburone, Nicosulfuron, Nonanoic acid (pelargonic acid), Norflurazone, Oleic acid (fatty acids), Orbencarb, Orthosulfamuron, Oryzalin, Oxadiargyl, Oxadiazon, Oxasulfuron, Oxaziclomefone, Oxyfluorfen, Paraquat, Paraquat dichloride, Paraquat dimethyl sulfate, Pebulate, Pendimethalin, Penoxsulam, Pentachlorophenol, Pentoxazone, Pethoxamide, Petroleum oil, phenmedipham, phenmedipham ethyl, 35 picloram, picloram dimethylammonium, picloram etexyl, picloram isoctyl, picloram methyl, picloram olamine, picloram potassium, picloram triethylammonium, picloram tripromine, picloram trolamine, picolinafen, pinoxaden, piperophos, Pretilachlor, Primisulfuron, Primisulfuron-Methyl, BCS241005-Abroad STR 259 Prodiamine, Profoxydim, Prometon, Prometryn, Propachlor, Propanil, Propaquizafop, Propazine, Propham, Propisochlor, Propoxycarbazone, Propoxycarbazone-Sodium, Propyrisulfuron, Propyzamide, Prosulfocarb, Prosulfuron, Pyraclonil, Pyraflufen, Pyraflufen-Ethyl, Pyraquinate, Pyrasulfotol, Pyrazolynate (Pyrazolate), Pyrazosulfuron, Pyrazosulfuron-Ethyl, Pyrazoxyfen, Pyribambenz, 5 Pyribambenz-Isopropyl, Pyribambenz-Propyl, Pyribenzoxime, Pyributicarb, Pyridafol, Pyridate, Pyriftalid, Pyriminobac, Pyriminobac-Methyl, Pyrimisulfan, Pyrithiobac, Pyrithiobac sodium, Pyroxasulfone, Pyroxsulam, Quinclorac, Quinclorac-dimethylammonium, Quinclorac-methyl, Quinmerac, Quinoclamine, Quizalofop, Quizalofop-Ethyl, Quizalofop-P, Quizalofop-P-Ethyl, Quizalofop-P-Tefuryl, QYM201, i.e. 1-{2-chloro-3-[(3-cyclopropyl-5-hydroxy-1-methyl-1H-pyrazol-4-yl)carbonyl]-6- 10 (trifluoromethyl)phe-nyl}piperidin-2-one, Rimisoxafen, Rimsulfuron, Saflufenacil, Sethoxydim, Siduron, Simazine, Simetryn, SL-261, Sulcotrione, Sulfentrazone, Sulfometuron, Sulfometuron-Methyl, Sulfosulfuron, , SYP-249, i.e.1-ethoxy-3-methyl-1-oxobut-3-en-2-yl-5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate, SYP-300, i.e.1-[7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4- dihydro-2H-1,4-benzoxazin-6-yl]-3-propyl-2-thioxoimidazolidine-4,5-dione, 2,3,6-TBA, TCA 15 (trichloroacetic acid) and its salts, e.g. TCA-ammonium, TCA-calcium, TCA-ethyl, TCA-magnesium, TCA-sodium, tebuthiuron, Tefuryltrione, Tembotrion, Tepraloxydim, Terbacil, Terbucarb, Terbumetone, Terbuthylazine, Terbutryn, Tetflupyrolimet, Thaxtomin, Thenylchlor, Thiazopyr, Thiencarbazone, Thiencarbazone-Methyl, Thifensulfuron, Thifensulfuron-Methyl, Thiobencarb, Tiafenacil, Tolpyralate, Topramezone, Tralkoxydim, Triafamon, Tri-allate, Triasulfuron,20 Triaziflam, tribenuron, tribenuron-methyl, triclopyr, triclopyr-butotyl, triclopyr-choline, triclopyr-ethyl, triclopyr-triethylammonium, trietazine, trifloxysulfuron, trifloxysulfuron sodium, trifludimoxazine, trifluralin, triflusulfuron, triflusulfuron-methyl, Tritosulfuron, Urea Sulfate, Vernolate, XDE-848, ZJ-0862, i.e. 3,4-dichloro-N-{2-[(4,6-dimethoxypyrimidin-2-yl)oxy]benzyl}aniline, 3-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-3,6-dihydropyrimidin-1(2H)-yl)phenyl)-5-25 methyl-4,5-dihydroisoxazole-5-carboxylic acid methyl ester, 3-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-3,6-dihydropyrimidin-1(2H)-yl)phenyl)-5-methyl-4,5-dihydroisoxazole-5-carboxylic acid ethyl ester, 3-(2-Chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-3,6-dihydropyrimidin- 1(2H)-yl)phenyl)-5-methyl-4,5-dihydroisoxazole-5-carboxylic acid, ethyl-[(3-{2-chloro-4-fluoro-5-[3-methyl- 2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenoxy}pyridin-2-yl)oxy]acetate, 3-chloro-30 2-[3-(difluoromethyl)isoxazolyl-5-yl]phenyl-5-chloropyrimidin-2-yl ether, 2-(3,4-dimethoxyphenyl)-4-[(2- hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-6-methylpyridazin-3(2H)-one, 2-({2-[(2-methoxyethoxy)methyl]-6-methylpyridin-3-yl}carbonyl)cyclohexane-1,3-dione, (5-hydroxy-1-methyl- 1H-pyrazol-4-yl)(3,3,4-trimethyl-1,1-dioxido-2,3-dihydro-1-benzothiophen-5-yl)methanone, 1-methyl-4-[(3,3,4-trimethyl-1,1-dioxido-2,3-dihydro-1-benzothiophen-5-yl)carbonyl]-1H-pyrazol-5-yl propane-1-35 sulfonate, 4-{2-Chloro-3-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-4-(methylsulfonyl)benzoyl}-1-methyl-1H-pyrazol-5-yl-1,3-dimethyl-1H-pyrazol-4-carboxylate; Cyanomethyl-4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridin-2-carboxylate, prop-2-yn-1-yl 4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol- BCS241005-Ausland STR 260 6-yl)pyridine-2-carboxylate, methyl 4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridine-2-carboxylate, Benzyl-4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridine-2-carboxylate, Ethyl-4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridine-2-carboxylate, Methyl 4-amino-3-chloro-5-fluoro 6-(7-fluoro-1-isobutyryl-1H-indol-6-yl)pyridine-2-carboxylate, methyl 6-(1-acetyl-7-fluoro-1H-indol-6-yl)- 5 4-amino-3-chloro-5-fluoropyridine-2-carboxylate, methyl 4-amino-3-chloro-6-[1-(2,2-dimethylpropanoyl)-7-fluoro-1H-indol-6-yl]-5-fluoropyridine-2-carboxylate, methyl 4-amino-3-chloro-5-fluoro-6-[7-fluoro-1- (methoxyacetyl)-1H-indol-6-yl]pyridine-2-carboxylate, potassium 4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridine-2-carboxylate, sodium 4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridine-2-carboxylate, Butyl-4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridin-2-carboxylate, 4-hydroxy-10 1-methyl-3-[4-(trifluoromethyl)pyridin-2-yl]imidazolidin-2-one, 3-(5-tert-butyl-1,2-oxazol-3-yl)-4- hydroxy-1-methylimidazolidin-2-one, 3-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-4-hydroxy-1-methylimidazolidin-2-one, 4-hydroxy-1-methoxy-5-methyl-3-[4-(trifluoromethyl)pyridin-2-yl]imidazolidin-2-one, 6-[(2-Hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-1,5-dimethyl-3-(2-methylphenyl)quinazoline-2,4(1H,3H)-dione, 3-(2,6-dimethylphenyl)-6-[(2-hydroxy-6-oxocyclohex-1-en-15 1-yl)carbonyl]-1-methylquinazolin-2,4(1H,3H)-dione, 2-[2-chloro-4-(methylsulfonyl)-3-(morpholin-4-ylmethyl)benzoyl]-3-hydroxycyclohex-2-en-1-one, 1-(2-carboxyethyl)-4-(pyrimidin-2-yl)pyridazin-1-ium salt (with appropriate Anions such as chloride, acetate or trifluoroacetate), 1-(2-carboxyethyl)-4- (pyridazin-3-yl)pyridazin-1-ium salt (with suitable anions such as chloride, acetate, or trifluoroacetate), 4-(pyridin-2-yl)-1-(2-sulfoethyl)pyridazin-1-ium salt (with suitable anions such as chloride, acetate, or trifluoroacetate), 4-(pyridazin-3-yl)-1-(2-sulfoethyl)pyridazin-1-ium salt (with suitable anions such as chloride, acetate, or trifluoroacetate), 1-(2-carboxyethyl)-4-(1,3-thiazol-2-yl)pyridazin-1-ium salt (with suitable anions such as chloride, acetate, or trifluoroacetate), 1-(2-carboxyethyl)-4-(1,3,4-thiadiazol-2-yl)pyridazin-1-ium salt (with suitable anions such as e.g. chloride, acetate or trifluoroacetate), methyl (2R)-2-{[(E)-({2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-25 (trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}methylidene)amino]oxy}propanoate, methyl (2S)- 2-{[(E)({2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}methylidene)amino]oxy}propanoate, methyl (2R/S)-2-{[(E)({2-chloro-4-fluoro-5-[3-methyl-2,6- dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}methylidene)amino]oxy}propanoate, (E)-2-(trifluoromethyl)benzaldehyde-O-{2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoyl}oxime, 2-fluoro-30 N-(5-methyl-1,3,4-oxadiazol-2-yl)-3-[(R)-propylsulfinyl]-4-(trifluoromethyl)benzamide, (2R)-2-[(4-amino-3,5-dichloro-6-fluoro-2-pyridyl)oxy]propanecarboxylic acid, 2-ethoxy-2-oxoethyl-1-{2-chloro-4-fluoro- 5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenoxy}cyclopropanecarboxylate, 2-methoxy-2-oxoethyl-1-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4- (trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenoxy}cyclopropane carboxylate, {[(1-{2-chloro-4-35fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenoxy}cyclopropyl)carbonyl]oxy}acetic acid, 2-(2-Bromo-4-chlorobenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one, methyl 3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6- BCS241005-Ausland STR 261 dihydropyrimidin-1(2H)-yl]phenyl}-3a,4,5,6-tetrahydro-6aH-cyclopenta[d][1,2]oxazole-6a-carboxylate, ethyl 3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-3a,4,5,6-tetrahydro-6aH-cyclopenta[d][1,2]oxazole-6a-carboxylate, methyl 3-{2-chloro-4-fluor- 5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-6-methyl-3a,4,5,6-5 tetrahydro-6aH-cyclopenta[d][1,2]oxazol-6a-carboxylate, 3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-6-methyl-3a,4,5,6-tetrahydro-6aH-cyclopenta[d][1,2]oxazol-6a-carboxylic acid, 3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-3a,4,5,6-tetrahydro-6aH-cyclopenta[d][1,2]oxazol-6a-carboxylic acid 10 Examples of plant growth regulators as possible mixing partners are: abscisic acid and related analogues [e.g. (2Z,4E)-5-[6-Ethynyl-1-hydroxy-2,6-dimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, methyl-(2Z,4E)-5-[6-ethynyl-1-hydroxy-2,6-dimethyl-4-oxocyclohex-2-en- 1-yl]-3-methylpenta-2,4-dienoate, (2Z,4E)-3-ethyl-5-(1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-15yl)penta-2,4-dienoic acid, (2E,4E)-5-(1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl)-3-(trifluoromethyl)penta-2,4-dienoic acid, methyl (2E,4E)-5-(1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl)-3-(trifluoromethyl)penta-2,4-dienoate, (2Z,4E)-5-(2-hydroxy-1,3-dimethyl-5- oxobicyclo[4.1.0]hept-3-en-2-yl)-3-methylpenta-2,4-dienoic acid], acibenzolar, acibenzolar-S-methyl, S-adenosylhomocysteine, allantoin, 2-aminoethoxyvinylglycine (AVG), aminooxyacetic acid and 20 related esters [e.g. (Isopropylidene)-aminooxyacetic acid-2-(methoxy)-2-oxoethyl ester, (Isopropylidene)-aminooxyacetic acid-2-(hexyloxy)-2-oxoethyl ester, (Cyclohexylidene)-aminooxyacetic acid-2-(isopropyloxy)-2-oxoethyl ester], 1-Aminocycloprop-1-ylcarboxylic acid, N-Methyl-1-aminocyclopropyl-1-carboxylic acid, 1-Aminocyclopropyl-1-carboxylic acid amide, substituted 1-Aminocyclopropyl-1-carboxylic acid derivatives as described in DE3335514, EP30287, DE2906507 or 25 US5123951, 1-Aminocyclopropyl-1-hydroxamic acid, 5-Aminolevulinic acid, Ancymidol, 6-Benzylaminopurine, Bikinin, Brassinolide, Brassinolide-ethyl, L-Canalin, catechin, and catechins (e.g., (2S,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol), chitooligosaccharides (CO; COs differ from LCOs in that they lack the fatty acid side chain characteristic of LCOs. COs, in some cases referred to as N-acetylchitooligosaccharides 30, are also composed of GlcNAc units, but have side chains that distinguish them from chitin molecules [(C8H13NO5)n, CAS No.1398-61-4] and chitosan molecules [(C5H11NO4)n, CAS No. 9012-76-4]), chitin-like compounds, chlormequat chloride, cloprop, cyclanilides, 3-(cycloprop-1-enyl)propionic acid, 1-[2-(4-cyano-3,5-dicyclopropylphenyl)acetamido]cyclohexanecarboxylic acid, 1-[2-(4-cyano-3,5-cyclopropylphenyl)acetamido]cyclohexanecarboxylic acid, 1-cyclopropenylmethanol, daminozide, dazomet, dazomet sodium, n-decanol, dikegulac, dikegulac sodium, endothal, endothal dipotassium, disodium, and mono(N,N-dimethylalkylammonium), ethephon, 1-ethylcyclopropene, flumetraline, BCS241005-Abroad STR 262 Flurenol, fluorenol-butyl, fluorenol-methyl, flurprimidol, forchlorfenuron, gibberellic acid, inabenfid, indole-3-acetic acid (IAA), 4-indole-3-ylbutyric acid, isoprothiolane, probenazole, jasmonic acid, jasmonic acid esters, or other derivatives (e.g., jasmonic acid methyl ester, jasmonic acid ethyl ester), lipochitooligosaccharides (LCO, in some cases also referred to as symbiotic nodulation signals (Nod 5 or Nod factors) or Myc factors), consist of an oligosaccharide backbone of β-1,4-linked N-acetyl-D-glucosamine residues (“GlcNAc”) with an N-linked fatty acid side chain condensed at the non-reducing end. As can be seen from the literature, they differ LCOs in the number of GlcNAc units in the backbone structure, in the length and saturation of the fatty acid chain, and in the substitution of the reducing and non-reducing sugar units), linoleic acid or its derivatives, linolenic acid or its derivatives, maleic hydrazide, mepiquat chloride, mepiquat pentaborate, 1-methylcyclopropene, 3-methylcyclopropene, methoxyvinylglycine (MVG), 3’-methylabscisic acid, 1-(4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide and related substituted (tetrahydroquinolin-6-yl)methanesulfonamides, (3E,3aR,8bS)-3-({[(2R)-4-methyl-5-oxo-2,5- 15 dihydrofuran-2-yl]oxy}methylene)-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]furan-2-one and related lactones as described in EP2248421, 2-(1-naphthyl)acetamide, 1-naphthylacetic acid, 2-naphthyloxyacetic acid, nitrophenolate mixture, 4-oxo-4[(2-phenylethyl)amino]butyric acid, paclobutrazol, 4-phenylbutyric acid and its salts (e.g., sodium 4-phenylbutanoate, potassium 4-phenylbutanoate), phenylalanines, N-phenylphthalamic acid, prohexadiones, prohexadione calcium, , 1-n-20 propylcyclopropene, putrescine, prohydrojasmon, rhizobitoxin, salicylic acid and methyl salicylates, Sarcosine, sodium cycloprop-1-en-1-yl acetate, sodium cycloprop-2-en-1-yl acetate, sodium 3-(cycloprop-2-en-1-yl)propanoate, sodium 3-(cycloprop-1-en-1-yl)propanoate, sidefungin, spermidine, spermine, strigolactone, tecnazene, thidiazuron, triacontanol, trinexapac, trinexapac-ethyl, tryptophan, tsitodef, uniconazole, uniconazole-P, 2-fluoro-N-(3-methoxyphenyl)-9H-25-purine-6-amine, 2-chloro-N-(3-methoxyphenyl)-9H-purine-6-amine. The following safeners, for example, are also suitable as combination partners for the compounds of general formula (I) according to the invention: S1) Compounds of formula (S1), 30 where the symbols and indices have the following meanings: nAis a natural number from 0 to 5, preferably 0 to 3; BCS241005-Abroad STR 263 RA 1is halogen, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, Nitro or (C1-C4)-Haloalkyl; ` ...) WAis an unsubstituted or substituted divalent heterocyclic residue from the group of division-saturated or aromatic five-membered heterocycles with 1 to 3 heteroring atoms from group 5 N and O, wherein at least one N atom and at most one O atom is contained in the ring, preferably a residue from the group (WA 1) to (WA 5), mAis 0 or 1; RA 2is ORA 3, SRA 3or NRA 3RA 4or a saturated or unsaturated 3- to 7-membered heterocycle with at least one N atom and up to 3 heteroatoms, preferably from group 10 O and S, which is linked via the N atom to the carbonyl group in (S1) and is unsubstituted or by residues from group (C1-C4)-Alkyl, (C1-C4)-Alkoxy or optionally substituted phenyl, preferably a residue of the formula ORA 3, NHRA 4or N(CH3)2, in particular the formula ORA 3; RA 3is hydrogen or an unsubstituted or substituted aliphatic hydrocarbon residue, 15 preferably with a total of 1 to 18 C atoms; RA 4is hydrogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy or substituted or unsubstituted phenyl; RA 5is H, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C1-C4)-Alkoxy(C1-C8)-Alkyl, cyano or COORA 9, in which RA 9Hydrogen, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C1-C4)-Alkoxy-(C1-C4)-alkyl, (C1-C6)-Hydroxyalkyl, (C3-C12)-Cycloalkyl or Tri-(C1-C4)-alkyl-silyl is; 20 RA 6, RA 7, RA 8are the same or different hydrogen, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C3-C12)-Cycloalkyl or substituted or unsubstituted phenyl; RA 10is H, (C3-C12)-Cycloalkyl, substituted or unsubstituted phenyl or substituted or unsubstituted heteroaryl; preferably: 25 a) compounds of the dichlorophenylpyrazolin-3-carboxylic acid type (S1a), preferably compounds such as 1-(2,4-dichlorophenyl)-5-(ethoxycarbonyl)-5-methyl-2-pyrazolin-3-carboxylic acid, BCS241005-Abroad STR 264 1-(2,4-Dichlorophenyl)-5-(ethoxycarbonyl)-5-methyl-2-pyrazolin-3-carboxylic acid ethyl ester (S1-1) ("Mefenpyr-diethyl"), and related compounds as described in WO-A-91/07874; b) Derivatives of dichlorophenylpyrazole carboxylic acid (S1b), preferably compounds such as 1-(2,4-dichlorophenyl)-5-methylpyrazole-3-carboxylic acid ethyl ester (S1-2), 1-(2,4-di-5-chlorophenyl)-5-isopropylpyrazole-3-carboxylic acid ethyl ester (S1-3), 1-(2,4-dichlorophenyl)-5-(1,1-dimethylethyl)pyrazole-3-carboxylic acid ethyl ester (S1-4) and related compounds as described in EP-A-333131 and EP-A-269806; c) derivatives of 1,5-diphenylpyrazole-3-carboxylic acid (S1c), preferably compounds such as ethyl 1-(2,4-dichlorophenyl)-5-phenylpyrazole-3-carboxylic acid ester (S1-5), methyl 1-(2-chlorophenyl)-5-phenylpyrazole-3-carboxylic acid ester (S1-6) and related compounds as described, for example, in EP-A-268554; d) compounds of the triazole carboxylic acid type (S1d), preferably compounds such as fenchlorazole(ethyl) ester, i.e. 1-(2,4-dichlorophenyl)-5-trichloromethyl-(1H)-1,2,4-triazol-3-carboxylic acid ethyl ester (S1-7), and related compounds as described in EP-A-174562 and EP-A-346620 15; e) compounds of the type of 5-benzyl or 5-phenyl-2-isoxazoline-3-carboxylic acid or 5,5-diphenyl-2-isoxazoline-3-carboxylic acid (S1e), preferably compounds such as 5-(2,4-dichlorobenzyl)-2-isoxazoline-3-carboxylic acid ethyl ester (S1-8) or 5-phenyl-2-isoxazoline-3-carboxylic acid ethyl ester (S1-9) and related compounds as described in WO-A-91/0820220, or 5,5-diphenyl-2-isoxazoline-3-carboxylic acid (S1-10) or 5,5-diphenyl-2-isoxazoline-3-carboxylic acid ethyl ester (S1-11) ("isoxadifen-ethyl") or -n-propyl ester (S1-12) or the 5-(4-fluorophenyl)-5-phenyl-2-isoxazoline-3-carboxylic acid ethyl ester (S1-13) as described in patent application WO-A-95/07897. f) Compounds of the triazolyloxyacetic acid derivative type (S1f), preferably compounds such as 25 Methyl-{[1,5-bis(4-chloro-2-fluorophenyl)-1H-1,2,4-triazol-3-yl]oxy}acetate (S1-14) or {[1,5-Bis(4-chloro-2-fluorophenyl)-1H-1,2,4-triazol-3-yl]oxy}acetic acid (S1-15) or Methyl-{[5-(4-chloro-2-fluorophenyl)-1-(2,4-difluorophenyl)-1H-1,2,4-triazol-3-yl]oxy}acetate (S1-16) or {[5-(4-chloro-2-fluorophenyl)-1-(2,4-difluorophenyl)-1H-1,2,4-triazol-3-yl]oxy}acetic acid (S1-17) or Methyl-{[1-(4- chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-1H-1,2,4-triazol-3-yl]oxy}acetate (S1-18) or {[1-(4-chloro- 30 2-fluorophenyl)-5-(2,4-difluorophenyl)-1H-1,2,4-triazol-3-yl]oxy}acetic acid (S1-19), as described in patent application WO2021105101 BCS241005-Ausland STR 265 S2) quinoline derivatives of the formula (S2), where the symbols and indices have the following meanings: RB 1is halogen, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, Nitro or (C1-C4)-Haloalkyl; 5 nBis a natural number from 0 to 5, preferably 0 to 3; RB 2is ORB 3, SRB 3or NRB 3RB 4or a saturated or unsaturated 3- to 7-membered heterocycle with at least one N atom and up to 3 heteroatoms, preferably from the group O and S, which is linked via the N atom to the carbonyl group in (S2) and is unsubstituted or by residues from the group (C1-C4)-Alkyl, (C1-C4)-Alkoxy 10 or optionally substituted phenyl, preferably a residue of the formula ORB 3, NHRB 4or N(CH3)2, in particular the formula ORB 3; RB 3is hydrogen or an unsubstituted or substituted aliphatic hydrocarbon residue, preferably with a total of 1 to 18 C atoms; RB 4is hydrogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy or substituted or unsubstituted phenyl; 15 TBis a (C1or C2)-Alkanediyl chain, unsubstituted or with one or two (C1-C4)-alkyl groups or with [(C1-C3)-Alkoxy]-carbonyl substituted; preferably: a) compounds of the type of 8-quinoline oxyacetic acid (S2a), preferably (5-chloro-8-quinolineoxy)acetic acid (1-methylhexyl) ester ("cloquintocet-mexyl") (S2-1), (5-chloro-8-20-quinolineoxy)acetic acid (1,3-dimethyl-but-1-yl) ester (S2-2), (5-chloro-8-quinolineoxy)acetic acid 4-allyloxy-butyl ester (S2-3), (5-chloro-8-quinolineoxy)acetic acid 1-allyloxy-prop-2-yl ester (S2-4), (5-chloro-8-quinolineoxy)acetic acid ethyl ester (S2-5), (5-chloro-8-quinolineoxy)acetic acid methyl ester (S2-6), (5-chloro-8-quinolineoxy)acetic acid allyl ester (S2-7), (5-Chloro-8-quinolineoxy)acetic acid 2-(2-propylidene-iminoxy)-1-ethyl ester (S2-8), (5-Chloro-8-quinolineoxy)acetic acid 2-oxo-prop-1-yl ester (S2-9) and 25 related compounds as described in EP-A-86750, EP-A-94349 and EP-A-191736 or EP-A-0492 366, as well as (5-Chloro-8-quinolineoxy)acetic acid (S2-10), its hydrates and salts, BCS241005-Foreign STR 266, for example, their lithium, sodium, potassium, calcium, magnesium, aluminum, iron, ammonium, quaternary ammonium, sulfonium, or phosphonium salts as described in WO-A-2002/34048; b) compounds of the type of (5-chloro-8-quinolineoxy)malonic acid (S2b), preferably 5 compounds such as (5-chloro-8-quinolineoxy)malonic diethyl ester, (5-chloro-8-quinolineoxy)malonic diallyl ester, (5-chloro-8-quinolineoxy)malonic methyl ethyl ester, and related compounds as described in EP-A-0582198. S3) Compounds of formula (S3) 10 where the symbols and indices have the following meanings: RC 1is (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C2-C4)-Alkenyl, (C2-C4)-Haloalkenyl, (C3-C7)-Cycloalkyl, preferably dichloromethyl; RC 2, RC 3are the same or different hydrogen, (C1-C4)-Alkyl, (C2-C4)-Alkenyl, (C2-C4)Alkynyl, (C1- C4)Haloalkyl, (C2-C4)Haloalkenyl, (C1-C4)Alkylcarbamoyl-(C1-C4)alkyl, (C2-C4)Alkenyl- 15 carbamoyl-(C1-C4)alkyl, (C1-C4)Alkoxy-(C1-C4)alkyl, dioxolanyl-(C1-C4)alkyl, thiazolyl, furyl, furylalkyl, thienyl, piperidyl, substituted or unsubstituted phenyl, or RC 2and RC 3together they form a substituted or unsubstituted heterocyclic ring, preferably an oxazolidine, thiazolidine, piperidine, morpholine, hexahydropyrimidine or benzoxazine ring; preferably: active ingredients of the dichloroacetamide type, which are frequently used as pre-emergence safeners (soil-active safeners), such as... B. "Dichlormid" (N,N-diallyl-2,2-dichloroacetamide) (S3-1), "R-29148" (3-dichloroacetyl-2,2,5-trimethyl-1,3-oxazolidine) from Stauffer (S3-2), "R-28725" (3-dichloroacetyl-2,2,-dimethyl-1,3-oxazolidine) from Stauffer (S3-3), "Benoxacor" (4-dichloroacetyl-3,4-dihydro-3-methyl-2H-1,4-benzoxazine) (S3-4), "PPG-1292" (N-allyl-N-[(1,3-dioxolan-2-yl)-methyl]-25 dichloracetamide) from PPG Industries (S3-5), "DKA-24" (N-allyl-N- [(allylaminocarbonyl)methyl]-dichloroacetamide) from Sagro-Chem (S3-6), "AD-67" or "MON 4660" (3-Dichloroacetyl-1-oxa-3-aza-spiro[4,5]decane) from Nitrokemia or Monsanto (S3-7), "TI-35" (1-Dichloroacetyl-azepine) from TRI-Chemical RT (S3-8), "Diclonon" (Dicyclonon) or "BAS145138" or "LAB145138" (S3-9) ((RS)-1-Dichloroacetyl- 3,3,8a-trimethylperhydropyrrolo[1,2-a]pyrimidin-6-one) from BASF, "Furilazol" or BCS241005-Abroad STR 267 "MON 13900" ((RS)-3-Dichloroacetyl-5-(2-furyl)-2,2-dimethyloxazolidine) (S3-10); and its (R)-isomer (S3-11). S4) N-acylsulfonamides of formula (S4) and their salts, 5 where the symbols and indices have the following meanings: XDis CH or N; RD 1is CO-NRD 5RD 6or NHCO-RD 7; RD 2is halogen, (C1-C4)-Haloalkyl, (C1-C4)-Haloalkoxy, Nitro, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, (C1-10°C4)-Alkylsulfonyl, (C1-C4)-Alkoxycarbonyl or (C1-C4)-Alkylcarbonyl; RD 3is hydrogen, (C1-C4)-Alkyl, (C2-C4)-Alkenyl or (C2-C4)-Alkynyl; RD 4is halogen, nitro, (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Haloalkoxy, (C3-C6)-Cycloalkyl, Phenyl, (C1-C4)-Alkoxy, Cyano, (C1-C4)-Alkylthio, (C1-C4)-Alkylsulfinyl, (C1-C4)- Alkylsulfonyl, (C1-C4)-Alkoxycarbonyl or (C1-C4)-Alkylcarbonyl; 15 RD 5is hydrogen, (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, (C5-C6)- Containing cycloalkenyl, phenyl or 3- to 6-membered heterocyclylDHeteroatoms from the group nitrogen, oxygen and sulfur, wherein the last seven mentioned residues are replaced by vDSubstituents from the halogen group, (C1-C6)-Alkoxy, (C1-C6)-Haloalkoxy, (C1-C2)- Alkylsulfinyl, (C1-C2)-Alkylsulfonyl, (C3-C6)-Cycloalkyl, (C1-C4)-Alkoxycarbonyl, (C1-C4)-20 Alkylcarbonyl and phenyl and, in the case of cyclic residues, also (C1-C4)-Alkyl and (C1-C4)- Haloalkyl substituted; RD 6is hydrogen, (C1-C6)-Alkyl, (C2-C6)-Alkenyl or (C2-C6)-Alkynyl, wherein the last three residues are replaced by vDResidues from the group halogen, hydroxy, (C1-C4)-Alkyl, (C1-C4)- Alkoxy and (C1-C4)-Alkylthio are substituted, or 25 RD 5and RD 6together with the nitrogen atom it carries, they form a pyrrolidinyl or piperidinyl residue; BCS241005-Abroad STR 268 RD 7is hydrogen, (C1-C4)-Alkylamino, Di-(C1-C4)-alkylamino, (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, wherein the last two residues are replaced by vDSubstituents from the halogen group, (C1-C4)- Alkoxy, (C1-C6)-Haloalkoxy and (C1-C4)-Alkylthio and in the case of cyclic residues also (C1-C4)- Alkyl and (C1-C4)-haloalkyl are substituted; 5 nDis 0, 1, or 2; mDis 1 or 2; vDis 0, 1, 2 or 3; preferably compounds of the type N-acylsulfonamides, e.g. of the following formula (S4)a), which are known, for example, from WO-A-97/45016 10 where RD 7(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, wherein the last two residues are replaced by vDSubstituents from the halogen group, (C1-C4)-Alkoxy, (C1-C6)-Haloalkoxy and (C1-C4)-Alkylthio and in the case of 15 cyclic residues also (C1-C4)-Alkyl and (C1-C4are substituted with )-haloalkyl; RD 4Halogen, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, CF3;mD1 or 2; vDis 0, 1, 2 or 3; as well as acylsulfamoylbenzoic acid amides, e.g. of the following formula (S4b), which are known, for example, from 20 WO-A-99/16744, ...e.g., such as those in which RD 5= Cyclopropyl and (RD 4) = 2-OMe ("Cyprosulfamide", S4-1), BCS241005-Abroad STR 269 RD 5= Cyclopropyl and (RD 4) = 5-Cl-2-OMe is (S4-2), RD 5= Ethyl and (RD 4) = 2-OMe is (S4-3), RD 5= Isopropyl and (RD 4) = 5-Cl-2-OMe is (S4-4) and RD 5= Isopropyl and (RD 4) = 2-OMe is (S4-5). 5 as well as compounds of the type of N-acylsulfamoylphenylureas of formula (S4c), which are known, for example, from EP-A-365484, where 10 RD 8and RD 9independently of each other hydrogen, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C3-C6)-Alkenyl, (C3-C6)-Alkynyl, RD 4Halogen, (C1-C4)Alkyl, (C1-C4)Alkoxy, CF3mD1 or 2 means; for example, 15 1-[4-(N-2-Methoxybenzoylsulfamoyl)phenyl]-3-methylurea, 1-[4-(N-2-Methoxybenzoylsulfamoyl)phenyl]-3,3-dimethylurea, 1-[4-(N-4,5-Dimethylbenzoylsulfamoyl)phenyl]-3-methylurea. S5) Active ingredients from the class of hydroxyaromatics and aromatic-aliphatic 20 carboxylic acid derivatives (S5), e.g. 3,4,5-triacetoxybenzoic acid ethyl ester, 3,5-di-methoxy-4-hydroxybenzoic acid, 3,5-dihydroxybenzoic acid, 4-hydroxysalicylic acid, 4-fluorosalicyclic acid, 2-hydroxycinnamic acid, 2,4-dichlorocinnamic acid, as described in WO-A-2004/084631, WO-A-2005/015994, WO-A-2005/016001. S6) active ingredients from the class of 1,2-dihydroquinoxalin-2-ones (S6), e.g. 25 1-methyl-3-(2-thienyl)-1,2-dihydroquinoxalin-2-one, 1-methyl-3-(2-thienyl)-1,2-dihydroquinoxalin-2-thione, 1-(2-Aminoethyl)-3-(2-thienyl)-1,2-dihydro-quinoxalin-2-one hydrochloride, 1-(2- BCS241005-Abroad STR 270 Methylsulfonylaminoethyl)-3-(2-thienyl)-1,2-dihydroquinoxa-lin-2-one, as described in WO-A-2005/112630. S7) Compounds of formula (S7), as described in WO-A-1998/38856 5 where the symbols and indices have the following meanings: RE 1, RE 2are independent of each other halogen, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkyl, (C1- C4)-Alkylamino, Di-(C1-C4)-Alkylamino, Nitro; AEis COORE 3or COSRE 4RE 3, RE 4are independent of each other hydrogen, (C1-C4)-Alkyl, (C2-C6)-Alkenyl, (C2-C4)-Alkynyl, 10 Cyanoalkyl, (C1-C4)-Haloalkyl, phenyl, nitrophenyl, benzyl, halobenzyl, pyridinylalkyl and alkylammonium, nE 1is 0 or 1 nE 2, nE 3are independently of each other 0, 1 or 2, preferably diphenyl methoxyacetic acid, diphenyl methoxyacetic acid ethyl ester, diphenyl methoxyacetic acid methyl ester (CAS Reg. No. 41858-19-9) (S7-1). S8) Compounds of formula (S8), as described in WO-A-98/27049 where XFCH or N, nFin the event that XF=N is an integer from 0 to 4 and 20 in the case that XF=CH is an integer from 0 to 5, ``` BCS241005-Abroad STR 271 RF 1Halogen, (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy, Nitro, (C1- C4)-Alkylthio, (C1-C4)-Alkylsulfonyl, (C1-C4)-Alkoxycarbonyl, possibly substituted. Phenyl, possibly substituted phenoxy, RF 2hydrogen or (C1-C4)-Alkyl, 5 RF 3Hydrogen, (C1-C8)-Alkyl, (C2-C4)-Alkenyl, (C2-C4)-Alkynyl, or aryl, wherein each of the aforementioned C-containing residues is unsubstituted or substituted by one or more, preferably up to three identical or different residues from the group consisting of halogen and alkoxy; mean, or their salts, preferably compounds wherein 10 XFCH, nFan integer from 0 to 2, RF 1Halogen, (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy, RF 2hydrogen or (C1-C4)-Alkyl, RF 3Hydrogen, (C1-C8)-Alkyl, (C2-C4)-Alkenyl, (C2-C4)-Alkynyl, or aryl, wherein each of the aforementioned 15 C-containing residues is unsubstituted or substituted by one or more, preferably up to three, identical or different residues from the group consisting of halogen and alkoxy, or their salts. S9) Active ingredients from the class of 3-(5-tetrazolylcarbonyl)-2-quinolones (S9), e.g. 1,2-Dihydro-4-hydroxy-1-ethyl-3-(5-tetrazolylcarbonyl)-2-quinolone (CAS Reg. No. 219479-18-2), 1,2-20-Dihydro-4-hydroxy-1-methyl-3-(5-tetrazolylcarbonyl)-2-quinolone (CAS Reg. No. 95855-00-8), as described in WO-A-1999/000020. S10) Connections of the formulas (S10a) or (S10b) as described in WO-A-2007/023719 and WO-A-2007/023764 BCS241005-Abroad STR 272 wherein RG 1Halogen, (C1-C4)-Alkyl, Methoxy, Nitro, Cyano, CF3, OCF3YG, ZGindependently of each other O or S, nGan integer from 0 to 4, 5 RG 2(C1-C16)-Alkyl, (C2-C6)-Alkenyl, (C3-C6)-cycloalkyl, aryl; Benzyl, halobenzyl, RG 3hydrogen or (C1-C6)-Alkyl means. S11) Active substances of the oxyimino compound type (S11) known as seed dressings, such as e.g. B. "Oxabetrinil" ((Z)-1,3-dioxolan-2-ylmethoxyimino(phenyl)acetonitrile) (S11-1), known as a seed treatment safener for millet against damage caused by metolachlor, "Fluxofenim" (1-(4-10 Chlorophenyl)-2,2,2-trifluoro-1-ethanone-O-(1,3-dioxolan-2-ylmethyl)-oxime) (S11-2), known as a seed treatment safener for millet against damage caused by metolachlor, and "Cyometrinil" or "CGA-43089" ((Z)-cyanomethoxyimino(phenyl)acetonitrile) (S11-3), known as a seed treatment safener for millet against damage caused by metolachlor. S12) Active substances from the class of isothiochromanones (S12), such as methyl-[(3-oxo-1H-2- 15 benzothiopyran-4(3H)-ylidene)methoxy]acetate (CAS Reg. No. 205121-04-6) (S12-1) and related compounds from WO-A-1998/13361. S13) One or more compounds from group (S13): "Naphthalic anhydride" (1,8-naphthalenedicarboxylic anhydride) (S13-1), known as a seed treatment safener for maize against damage from thiocarbama herbicides, "Fenclorim" (4,6-dichloro-2-phenylpyrimidine) (S13-2), known as a safener for pretilachlor in sown rice, "Flurazole" (benzyl-2-chloro-4-trifluoromethyl-1,3-thiazol-5-carboxylate) (S13-3), known as a seed treatment safener for millet against damage from alachlor and metolachlor, "CL 304415" (CAS Reg. No. 31541-57-8) (4-carboxy-3,4-dihydro-2H-1-benzopyran-4-acetic acid) (S13-4) of American Cyanamid, known as a corn safener against imidazolinone damage, "MG 191" (CAS Reg. No. 96420-72-3) (2-Dichloromethyl-2-25-methyl-1,3-dioxolane) (S13-5) of Nitrokemia, known as a corn safener, "MG-838" (CAS Reg. No. 133993-74-5) (2-propenyl 1-oxa-4-azaspiro[4.5]decane-4-carbodithioate) (S13-6) of Nitrokemia, "Disulfoton" (O,O-Diethyl S-2-ethylthioethyl phosphordithioate) (S13-7), "Dietholate" (O,O-Diethyl-O-phenylphosphorothioate) (S13-8), "Mephenate" (4-Chlorophenyl methylcarbamate) (S13-9). 30 S14) Active substances that, in addition to a herbicidal effect against weeds, also exhibit safener activity in cultivated plants such as rice, e.g. BCS241005-Abroad STR 273 "Dimepiperate" or "MY-93" (S-1-Methyl-1-phenylethyl-piperidine-1-carbothioate), known as a safener for rice against damage from the herbicide Molinate, "Daimuron" or "SK 23" (1-(1-Methyl-1-phenylethyl)-3-p-tolyl-urea), known as a safener for rice against damage from the herbicide Imazosulfuron, "Cumyluron" = "JC-940" (3-(2-Chlorophenylmethyl)-1-(1-methyl-1-phenylethyl)urea, 5 see JP-A-60087254), known as a safener for rice against damage from some herbicides, "Methoxyphenone" or "NK 049" (3,3'-Dimethyl-4-methoxy-benzophenone), which known as a safener for rice against damage caused by some herbicides, "CSB" (1-bromo-4-(chloromethylsulfonyl)benzene) from Kumiai, (CAS Reg. No. 54091-06-4), which is known as a safener against damage caused by some herbicides in rice. 10 S15) Compounds of formula (S15) or their tautomers as described in WO-A-2008/131861 and WO-A-2008/131860 where RH 1a (C1-C6)-haloalkyl group means and 15 RH 2Hydrogen or halogen means and RH 3, RH 4independently of each other hydrogen, (C1-C16)-Alkyl, (C2-C16)-Alkenyl or (C2-C16)-Alkynyl, wherein each of the last 3 residues is unsubstituted or by one or more residues from the group halogen, hydroxy, cyano, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy, (C1-C4)-Alkylthio, (C1-C4)-Alkylamino, Di[(C1-C4)-alkyl]-amino, [(C1-C4)-Alkoxy]-carbonyl, [(C1-C4)Haloalkoxy]- 20 carbonyl, (C3-C6)-Cycloalkyl, which is unsubstituted or substituted, phenyl, which is unsubstituted or substituted, and heterocyclyl, which is unsubstituted or substituted, or (C3- C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C3-C6)-Cycloalkyl fused to one side of the ring with a 4 to 6-membered saturated or unsaturated carbocyclic ring, or (C4-C6)Cycloalkenyl, which is condensed on one side of the ring with a 4 to 6-membered saturated or 25 unsaturated carbocyclic ring, wherein each of the latter 4 residues is unsubstituted or by one or more residues from the group halogen, hydroxy, cyano, (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy, (C1-C4)-Alkylthio, (C1-C4)- Alkylamino, Di[(C1-C4)-alkyl]-amino, [(C1-C4)-Alkoxy]-carbonyl, [(C1-C4)-Haloalkoxy]-carbonyl, BCS241005-Abroad STR 274 (C)3-C6)-Cycloalkyl, which is unsubstituted or substituted, phenyl, which is unsubstituted or substituted, and heterocyclyl, which is unsubstituted or substituted, means, or RH 3(C1-C4)-Alkoxy, (C2-C4)-Alkenyloxy, (C2-C6)-Alkynyloxy or (C2-C4)-Haloalkoxy means 5 and RH 4hydrogen or (C1-C4)-Alkyl means, or RH 3and RH 4together with the directly bonded N atom a four- to eight-membered heterocyclic ring, which in addition to the N atom may also contain further heteroring atoms, preferably up to two further heteroring atoms from the group N, O and S, and which is unsubstituted or by one or more residues from the group halogen, cyano, nitro, (C1- C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy and (C1-C4)-Alkylthio is substituted, means. S16) Active substances that are primarily used as herbicides, but also have a safener effect on crops, e.g. (2,4-Dichlorophenoxy)acetic acid (2,4-D), (4-Chlorphenoxy)acetic acid,15 (R,S)-2-(4-Chloro-o-tolyloxy)propionic acid (Mecoprop), 4-(2,4-Dichlorophenoxy)butyric acid (2,4-DB), (4-Chloro-o-tolyloxy)acetic acid (MCPA), 4-(4-Chloro-o-tolyloxy)butyric acid, 4-(4-Chlorphenoxy)butyric acid, 3,6-Dichloro-2-methoxybenzoic acid (Dicamba), 1-(Ethoxycarbonyl)ethyl-3,6-dichloro-2-methoxybenzoate (Lactidichloro-ethyl). Biological Examples 20 The following abbreviations for pest and cultivated plants are used in the tables and trial evaluations below: Pests tested: 25 ABUTH: Abutilon theophrasti AGSTE: Agrostis tenuis ALOMY: Alopecurus myosuroides AMAPA: Amaranthus palmeri AMARE: Amaranthus retroflexus 30 AVEFA: Avena fatua DIGSA: Digitaria sanguinalis DIPTE: Diplotaxis tenuis BCS241005-Abroad STR 275 ECHCG: Echinochloa crus-galli KCHSC: Kochia scoparia LOLPE: Lolium perenne LOLRI: Lolium rigidum 5 MATCH: Matricaria chamomilla MATIN: Matricaria inodora PHBPU: Pharbitis purpurea POAAN: Poa annua POLCO: Polygonum convolvulus 10 SETVI: Setaria viridis STEME: Stellaria media VERPE: Veronica persica VIOTR: Viola tricolor 15 Tested crops: BRSNW: Brassica napus GLXMA: Glycine max ORYSA: Oryza sativa TRZAS: Triticum aestivum 20 ZEAMX: Zea mays A. Herbicidal activity in early post-emergence. Seeds of mono- and dicotyledonous weeds are tested in 96-well microtiter plates in quartz sand. 25 are laid out and grown in the climate chamber under controlled growth conditions. 5 to 7 days after sowing, the experimental plants are treated at the cotyledon stage. The compounds according to the invention, formulated as emulsion concentrates (EC), are applied with a water volume equivalent to 2200 liters per hectare. After 9 to 12 days of the experimental plants remaining in the climate chamber under optimal growth conditions, the effect of the preparations is visually assessed in comparison to untreated controls. For example, 100% effect means plants have died, 0% effect means the same as the control plants. A1. Efficacy against AGSTE: In this test, for example, the following compounds according to the invention showed very good herbicidal activity (80% to 100%) at an application rate of 1900 g35 active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-36, I.1-38, I.1-40, I.1-47, I.1-49, I.1-50, I.1-52, I.1-53, I.1-68, I.1-70, I.1-80, I.1-93, I.1-143, I.1-145, I.2-1, I.1-152, I.1-153, I.2-5, I.2-7, I.1-155, I.1-156. I.1-157, I.1-158, I.2-8, BCS241005-Foreign STR 276 I.2-6, I.2-11, I.2-10, I.2-13, I.1-252, I.1-169, I.2-15, I.2-17, I.1-174, I.1-177, I.2-21, I.2-20, I.1-178, I.2- 36, I.2-25, I.2-32, I.2-28, I.2-27, I.2-29, I.1-185, I.3-13, I.3-17, I.1-189, I.1-190, I.1-202, I.1-203, I.1-200, I.1-201, I.1-207, I.1-212, I.1-213, I.3-9, I.1-259, I.2-37, I.1-260, I.2-44, I.1-272, I.1-274, I.1-280, I.1-284, I.1-288, I.1-294, I.1-302, I.1-303, I.2-75, I.2-82, I.2-84, I.1-316, I.1-317, I.1-315, I.2-95, I.1-5 355, I.1-356, I.1-334, I.1-338, I.1-348, I.1-337, I.1-347, I.1-346, I.1-336, I.1-359, I.1-362, I.1-363, I.1- 341, I.1-342, I.1-345, I.2-103, I.1-366, I.1-368, I.1-371, I.2-108, I.2-109, I.2-110, I.1-376, I.1-378, I.1- 379, I.1-380, I.1-393, I.1-394, I.1-397, I.1-398, I.1-399, I.1-400, I.1-401, I.2-120, I.1-403, I.1-405, I.1-412, I.2-121, I.2-122, I.2-123, I.2-125, I.2-145, I.1-418, I.1-419, I.1-420, I.1-422, I.2-148, I.1-427, I.2-156, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.2-162, I.1-435, I.1-437, I.1-438, I.2-166, I.2-167, I.2-10 170, I.1-439, I.1-440, I.1-441, I.1-442, I.2-171, I.2-172, I.2-173, I.2-177, I.1-443, I.1-445, I.2-181, I.2- 182, I.1-448, I.1-449, I.1-450, I.1-451, I.1-453, I.2-191, I.2-195, I.1-454, I.1-458, I.1-460, I.1-464, I.1- 466, I.1-470, I.1-557, I.1-556, I.1-483, I.1-484, I.1-486, I.1-487, I.1-493, I.1-494, I.1-495, I.1-496, I.1-497, I.2-206, I.2-207, I.1-513, I.1-514, I.1-515, I.2-211, I.1-517. The following compounds according to the invention also exhibited very good herbicidal activity (> 80%) at an application rate of 15,950 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-40, I.1-47, I.1-49, I.1-50, I.1-52, I.1-53, I.1-68, I.1-70, I.1-79, I.1-80, I.1-93, I.1-145, I.1-149, I.2-1, I.1-152, I.1-153, I.2-5, I.2-7, I.1-155, I.1-157, I.1-158, I.2-8, I.2-6, I.2-11, I.2-10, I.2-13, I.1-169, I.2-15, I.2-17, I.1-174, I.1-177, I.2-21, I.2-20, I.1-178, I.2-36, I.2-25, I.2-32, I.2- 28, I.2-27, I.2-29, I.3-13, I.3-17, I.1-189, I.1-190, I.1-202, I.1-203, I.1-200, I.1-201, I.1-207, I.1-212, I.1-20 213, I.1-214, I.1-259, I.1-260, I.1-272, I.1-274, I.1-280, I.1-294, I.2-75, I.2-82, I.2-84, I.1-316, I.1-317, I.1-315, I.2-95, I.1-355, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-359, I.1-361, I.1-362, I.1-363, I.1-341, I.1-345, I.2-103, I.1-370, I.1-371, I.2-108, I.2-109, I.2-110, I.1-376, I.1-379, I.1-393, I.1-394, I.1-396, I.1-398, I.1-399, I.1-400, I.1-401, I.2-120, I.1-403, I.1-412, I.2-121, I.2-122, I.2-123, I.2-125, I.2-145, I.1-418, I.1-420, I.1-422, I.2-148, I.1-427, I.2-156, I.1-430, I.1-431, I.1-432, I.1-433, I.1-25 434, I.1-435, I.1-437, I.1-438, I.2-166, I.2-167, I.2-169, I.2-170, I.1-439, I.1-440, I.1-441, I.1-442, I.2-171, I.2-172, I.2-173, I.2-177, I.1-443, I.1-445, I.2-181, I.2-182, I.1-448, I.1-449, I.1-450, I.1-451, I.1-453, I.2-191, I.2-195, I.1-454, I.1-456, I.1-458, I.1-460, I.1-462, I.1-464, I.1-466, I.1-468, I.1-470, I.1-558, I.1-557, I.1-556, I.1-487, I.1-493, I.1-494, I.1-495, I.1-496, I.1-497, I.2-206, I.1-513, I.1-514, I.1-515, I.2-211, I.1-517. The following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-40, I.1-47, I.1-49, I.1-50, I.1-52, I.1-53, I.1-68, I.1-70, I.1-79, I.1-80, I.1-93, I.1-143, I.1-145, I.1-149, I.2-1, I.1-152, I.1-153, I.2-5, I.1-155, I.1-157, I.1-158, I.2-8, I.2-6, I.2-11, I.2-10, I.2-13, I.1-252, I.1-169, I.2-15, I.2-17, I.1-174, I.1-177, I.2-21, I.2-20, I.1-178, I.2-36, I.2-25, I.2-32, I.2-27, I.2-29, I.1-190, I.1-202, I.1-203,35 I.1-200, I.1-201, I.1-206, I.1-207, I.1-212, I.1-213, I.1-259, I.2-37, I.1-260, I.1-272, I.1-274, I.1-279, I.1-280, I.1-281, I.1-290, I.2-75, I.2-82, I.2-84, I.1-316, I.1-317, I.1-315, I.2-95, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-359, I.1-362, I.1-363, I.1-341, I.1-345, I.2-103, I.1-371, I.2-108, I.2-110, BCS241005-Foreign STR 277 I.1-393, I.1-394, I.1-396, I.1-397, I.1-398, I.1-399, I.1-400, I.1-401, I.2-120, I.1-412, I.1-413, I.2-121, I.2-122, I.2-123, I.2-125, I.2-145, I.1-418, I.1-419, I.1-420, I.1-421, I.1-422, I.1-427, I.2-155, I.1-430, I.1-431, I.1-433, I.1-434, I.1-435, I.1-437, I.1-438, I.2-166, I.2-167, I.1-439, I.1-440, I.1-441, I.2-171, I.2-172, I.2-173, I.2-177, I.1-443, I.1-445, I.2-181, I.2-182, I.1-448, I.1-450, I.1-451, I.1-453, I.2-191, 5 I.2-195, I.1-454, I.1-456, I.1-458, I.1-460, I.1-462, I.1-464, I.1-466, I.1-468, I.1-470, I.1-558, I.1-557, I.1-556, I.1-478, I.1-487, I.1-493, I.1-494, I.1-495, I.1-496, I.1-497, I.2-206, I.1-513, I.1-514, I.1-515, I.2-211. Furthermore, the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-40, I.1-47, I.1-49, I.1-50, I.1-52, I.1-53, I.1-68, I.1-70, I.1-80, I.1-93, I.1-145, I.1-149, I.1-1, I.1-152, I.1-153 I.1-155, I.1-157, I.1-158, I.2-8, I.2-11, I.2-10, I.2-13, I.1-252, I.1-169, I.1-178, I.2-36, I.2-25, I.2-32, I.2-27, I.2-29, I.1-202, I.1-203, I.1-201, I.1-206, I.1-207, I.1-212, I.1-259, I.1-260, I.1-272, I.1-274, I.1-279, I.1-280, I.1-281, I.2-75, I.2-82, I.2-84, I.1-316, I.1-315, I.2-95, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-362, I.1-341, I.1-345, I.2-103, I.1-371, I.2-108, I.2-110, I.1-393, I.1-394, I.1-396, I.1-397, I.1-15 398, I.1-400, I.1-401, I.2-120, I.1-412, I.1-413, I.2-121, I.2-122, I.2-123, I.2-125, I.2-145, I.1-418, I.1-420, I.1-421, I.1-422, I.1-427, I.2-155, I.2-156, I.1-431, I.1-432, I.1-433, I.1-434, I.2-162, I.1-435, I.1-437, I.1-438, I.2-167, I.1-439, I.1-440, I.1-441, I.2-171, I.2-172, I.2-173, I.2-177, I.1-443, I.1-445, I.2-182, I.1-450, I.1-451, I.1-453, I.2-191, I.1-454, I.1-456, I.1-458, I.1-459, I.1-460, I.1-462, I.1-464, I.1-466, I.1-468, I.1-470, I.1-557, I.1-556, I.1-487, I.1-493, I.1-494, I.1-495, I.1-496, I.1-497, I.2-206, I.1-20 513, I.1-515, I.2-211. A2. Efficacy against LOLPE: In this test, for example, the following compounds according to the invention showed very good herbicidal activity (80% to 100%) at an application rate of 1900 g of active substance per hectare: I.1-12, I.1-13, I.1-14, I.1-16, I.1-18, I.1-19, I.1-21, I.1-22, I.1-26, I.1-29, I.1-25, I.1-35, I.1-36, I.1-38, I.1-40, I.1-49, I.1-52, I.1-53, I.1-66, I.1-68, I.1-80, I.1-93, I.1-145, I.1-146, I.1-1, I.1-152, I.1-153, I.1-155, I.1-157, I.1-158, I.2-11, I.2-10, I.2-13, I.1-169, I.1-174, I.1-178, I.2-36, I.2-32, I.2-27, I.2-29, I.1-198, I.1-203, I.1-260, I.1-272, I.1-274, I.1-280, I.1-285, I.2-82, I.2-84, I.1-316, I.1-317, I.1-315, I.2-95, I.1-338, I.1-337, I.1-347, I.1-346, I.1-357, I.1-362, I.1-341, I.1-344, I.1-345, I.2-103, I.2-104, I.1-371, I.2-108, I.2-110, I.1-379, I.1-385, I.1-390, I.1-394, I.1-395, I.1-396, I.1-401, I.2-30 123, I.2-125, I.2-145, I.1-418, I.1-420, I.1-422, I.2-156, I.1-429, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.1-438, I.2-167, I.1-439, I.1-441, I.2-172, I.2-173, I.2-177, I.1-443, I.2-182, I.1-451, I.2-191, I.2-195, I.1-454, I.1-458, I.1-460, I.1-464, I.1-466, I.1-468, I.1-470, I.1-478, I.1-490, I.1-494, I.1-495, I.1-497, I.2-206, I.1-513, I.1-514, I.2-211, I.1-517. The following compounds according to the invention also exhibited very good herbicidal activity (> 80%) at an application rate of 35,950 g of active substance per hectare: I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-223, I.1-32, I.1-35, I.1-40, I.1-49, I.1-52, I.1-53, I.1-68, I.1-80, I.1-93, I.1-145, I.1-149, I.1-152, I.1-153, I.1-155, I.2-10, I.2-13, I.1-255, I.1-169, I.1-174, I.1-178, I.2-32, I.2-27, I.2-29, I.1-203, I.1-201, BCS241005-Foreign STR 278 I.1-206, I.1-260, I.1-272, I.1-274, I.1-280, I.2-84, I.1-316, I.1-315, I.2-95, I.1-337, I.1-347, I.1-346, I.1- 357, I.1-359, I.1-340, I.1-341, I.1-345, I.2-103, I.1-371, I.2-108, I.1-379, I.1-393, I.1-394, I.1-395, I.1-401, I.2-121, I.2-122, I.2-123, I.2-125, I.2-135, I.1-418, I.1-422, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.2-162, I.1-435, I.1-437, I.1-438, I.2-166, I.2-167, I.2-169, I.1-439, I.1-441, I.2-172, I.2-173, I.2-5 177, I.1-443, I.2-182, I.1-451, I.1-453, I.2-191, I.1-454, I.1-456, I.1-458, I.1-460, I.1-464, I.1-466, I.1-470, I.1-556, I.1-478, I.1-487, I.1-491, I.1-495, I.1-496, I.1-513, I.2-211, I.1-517. The following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-32, I.1-40, I.1-68, I.1-80, I.1-145, I.1-149, I.1-152, I.1-153, I.1-155, I.1-157, I.2-11, I.2-10, I.2-13, I.1-174, I.2-32, I.2-27, I.1-260, I.1-272, I.1-274 I.1-279, I.1-280, I.2-82, I.2-84, I.1-316, I.1-315, I.2-95, I.1-334, I.1-337, I.1-347, I.1-346, I.1-357, I.1-359, I.1-341, I.1-345, I.1-371, I.2-108, I.1- 393, I.1-394, I.1-395, I.1-397, I.1-401, I.2-122, I.2-125, I.2-145, I.1-420, I.1-422, I.1-430, I.1-431, I.1- 433, I.1-434, I.1-437, I.1-438, I.1-439, I.1-441, I.2-172, I.2-177, I.1-443, I.2-182, I.1-453, I.2-191, I.1-454, I.1-456, I.1-458, I.1-460, I.1-468, I.1-470, I.1-558, I.1-472, I.1-487, I.1-495, I.1-496, I.1-513. 15 Furthermore, the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-12, I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-32, I.1-40, I.1-50, I.1-80, I.1-152, I.1-153, I.1-155, I.2-13, I.2-32, I.1-272, I.1-274, I.1-280, I.2-82, I.1-347, I.1-346, I.1-359, I.1-341, I.1-345, I.1-401, I.2-122, I.2-125, I.1-422, I.1-431, I.1-433, I.1-434, I.1-437, I.1-439, I.1-441, I.2-172, I.1-443, I.2-182, I.1-451, I.1-453, 20 I.1-458, I.1-464, I.1-466, I.1-470, I.1-495, I.1-496, I.1-513. A3. Efficacy against POAAN: In this test, for example, the following compounds according to the invention showed very good herbicidal activity (80% to 100%) at an application rate of 1900 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-25, I.1-32, I.1-35, I.1-36, I.1-40, I.1-47, I.1-49, I.1-50, I.1-52, I.1-54, I.1-66, I.1-68, I.1-70, I.1-80, I.1-93, I.1-145, I.1-150 I.2-1, I.1-152, I.1-153, I.1-155, I.1-156, I.1-157, I.1-158, I.2-10, I.2-13, I.1-169, I.1-174, I.1-177, I.1-178, I.2-32, I.2-27, I.2-29, I.1-202, I.1-203, I.1-200, I.1-201, I.1-212, I.1-213, I.1-259, I.1-272, I.1-274, I.1-280, I.2-82, I.1-316, I.1-317, I.1-355, I.1-356, I.1-334, I.1-337, I.1-347, I.1-346, I.1-357, I.1-359, I.1-362, I.1-363, I.1-341, I.1-342, I.1-345, I.2-103, I.1-371, I.1-377, I.1-378, I.1-389, I.1-30 394, I.1-397, I.1-398, I.1-399, I.1-400, I.1-401, I.1-404, I.2-121, I.2-122, I.2-125, I.1-420, I.1-422, I.1-427, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-170, I.1-439, I.1-440, I.1-441, I.1-442, I.2-171, I.1-443, I.2-181, I.2-182, I.1-448, I.1-451, I.2-191, I.1-458, I.1-557, I.1-556, I.1-483, I.1-484, I.1-493, I.1-494, I.1-495, I.1-496, I.1-513, I.1-515, I.2-211. The following compounds according to the invention also exhibited very good herbicidal activity (> 80%) at an application rate of 35,950 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-40, I.1-47, I.1-49, I.1-50, I.1-68, I.1-70, I.1-80, I.1-93, I.1-143, I.1-145, I.1-150, I.1-1, I.1-152, I.1-153, I.1-155, I.1-156, I.1-157, I.1-158, I.2-10, I.2-13, I.1-169, I.1-174, I.1-177, BCS241005-Abroad STR 279 I.2-32, I.2-27, I.2-29, I.1-202, I.1-203, I.1-200, I.1-201, I.1-212, I.1-213, I.1-259, I.1-272, I.1-274, I.1- 280, I.1-281, I.2-82, I.1-316, I.1-317, I.1-356, I.1-334, I.1-337, I.1-347, I.1-346, I.1-357, I.1-362, I.1-363, I.1-341, I.1-342, I.1-345, I.2-103, I.1-371, I.2-110, I.1-377, I.1-397, I.1-398, I.1-399, I.1-400, I.1-401, I.2-121, I.2-122, I.2-123, I.2-125, I.1-420, I.1-422, I.1-427, I.1-430, I.1-431, I.1-432, I.1-433, I.1-5 434, I.1-435, I.1-437, I.2-166, I.1-439, I.1-440, I.1-441, I.1-442, I.1-443, I.2-182, I.1-448, I.1-451, I.2-191, I.1-458, I.1-470, I.1-557, I.1-556, I.1-484, I.1-493, I.1-494, I.1-495, I.1-496, I.1-513, I.1-515, I.2-211. The following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-36, I.1-40, I.1-47, I.1-49, I.1-50, I.1-68, I.1-70, 10 I.1-79, I.1-80, I.1-93, I.1-143, I.1-145, I.1-152, I.1-153, I.1-155, I.1-156, I.1-157, I.1-158, I.2-10, I.2-13, I.1-169, I.1-174, I.2-32, I.2-27, I.2-29, I.1-202, I.1-203, I.1-201, I.1-212, I.1-213, I.1-259, I.1-272, I.1-274, I.1-280, I.1-281, I.2-82, I.2-84, I.1-316, I.1-317, I.1-315, I.1-334, I.1-337, I.1-347, I.1-346, I.1-362, I.1-363, I.1-341, I.1-345, I.2-103, I.1-371, I.2-110, I.1-397, I.1-398, I.1-400, I.1-401, I.2-122, I.2-123, I.2-125, I.1-420, I.1-422, I.1-427, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-166, 15 I.1-439, I.1-440, I.1-441, I.1-443, I.2-182, I.1-451, I.2-191, I.1-458, I.1-470, I.1-556, I.1-493, I.1-494, I.1-495, I.1-496, I.1-513, I.1-515, I.2-211. Furthermore, the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-32, I.1-35, I.1-36, I.1-40, I.1-47, I.1-49, I.1-50, I.1-68, I.1-70, I.1-80, I.1-143, I.1-145, I.1-2-1, I.1-152, I.1-20, I.1-153, I.1-155, I.1-156, I.1-157 I.1-158, I.2-10, I.2-13, I.1-174, I.2-32, I.2-27, I.2-29, I.1-203, I.1-201, I.1-212, I.1-213, I.1-259, I.1-274, I.1-280, I.2-82, I.2-84, I.1-316, I.1-317, I.1-334, I.1-337, I.1-347, I.1-346, I.1-363, I.1-341, I.1-345, I.2-103, I.1-371, I.1-397, I.1-398, I.1-400, I.1-401, I.2-123, I.2-125, I.1-420, I.1-422, I.1-427, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.1-439, I.1-440, I.1-443, I.2-182, I.1-470, I.1-484, I.1-495, I.1-496, I.1-513, I.1-515. 25 A4. Efficacy against SETVI: In this test, for example, the following compounds according to the invention showed very good herbicidal activity (80% to 100%) at an application rate of 1900 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-18, I.1-19, I.1-32, I.1-35, I.1-40, I.1-50, I.1-52, I.1-53, I.1-66, I.1-68, I.1-80, I.1-93, I.1-145, I.1-150, I.2-1, I.1-152, I.1-153, I.2-5, I.1-155, I.1-156, I.1-157, I.1-158, I.1-255 I.1-174, I.1-178, I.1-179, I.2-32, I.2-27, I.2-29, I.1-190, I.1-202, I.1-200, I.1-201, I.1-207, I.1-260, I.2-73, I.2-84, I.1-316, I.1-315, I.2-95, I.1-356, I.1-338, I.1-348, I.1-337, I.1-335, I.1-347, I.1-346, I.1-357, I.1-359, I.1-323, I.2-90, I.1-361, I.1-362, I.1-341, I.1-344, I.1-345, I.2-103, I.2-104, I.1-371, I.2-110, I.1-376, I.1-378, I.1-379, I.1-385, I.1-387, I.1-397, I.1-400, I.1-401, I.1-412, I.2-121, I.1- 418, I.1-422, I.1-424, I.2-155, I.2-156, I.1-428, I.1-430, I.1-431, I.1-432, I.1-434, I.1-435, I.1-437, I.1-35 438, I.2-169, I.1-439, I.1-441, I.2-172, I.2-173, I.2-174, I.1-445, I.2-182, I.1-451, I.2-189, I.2-191, I.2-195, I.1-458, I.1-460, I.1-464, I.1-470, I.1-558, I.1-557, I.1-556, I.1-487, I.1-493, I.1-494, I.1-495, I.1-496, I.1-497, I.2-206, I.1-508, I.1-513, I.1-514, I.1-515, I.1-516, I.2-211, I.1-517, I.1-518. The following The compounds according to the invention (BCS241005-Ausland STR 280) also exhibited very good herbicidal activity (> 80%) at an application rate of 950 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-18, I.1-19, I.1-32, I.1-35, I.1-40, I.1-50, I.1-52, I.1-66, I.1-68, I.1-70, I.1-80, I.1-93, I.1-145, I.1-149, I.1-150, I.2-1, I.1-152, I.1-153, I.1-157, I.2-10, I.2-13, I.1-174, I.1-177 I.1-178, I.2-32, I.2-27, I.2-29, I.1-202, I.1-201, I.1-207, I.1-5 260, I.1-271, I.1-272, I.2-75, I.2-84, I.1-308, I.1-316, I.1-315, I.1-355, I.1-356, I.1-338, I.1-348, I.1-337, I.1-347, I.1-346, I.1-359, I.1-362, I.1-341, I.1-345, I.2-103, I.1-371, I.2-110, I.1-376, I.1-385, I.1-397, I.1-400, I.1-412, I.2-122, I.2-123, I.2-125, I.1-418, I.1-422, I.2-155, I.2-156, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-167, I.2-169, I.1-439, I.1-441, I.2-172, I.2-173, I.2-177, I.1-445, I.2-182, I.1-451, I.2-191, I.2-195, I.1-454, I.1-456, I.1-458, I.1-464, I.1-466, I.1-468, I.1-470, I.1-558, 10 I.1-557, I.1-556, I.1-472, I.1-487, I.1-494, I.1-495, I.1-496, I.1-497, I.2-206, I.1-513, I.1-515, I.2-211, I.1-517. The following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-18, I.1-26, I.1-32, I.1-35, I.1-40, I.1-49, I.1-50, I.1-52, I.1-68, I.1-70, I.1-80, I.1-93, I.1-145, I.1-152, I.1-153, I.1-155, I.2-10, I.1-174, I.1-177, I.1-178, I.2-27, I.2-29, I.1-201, I.1-207, I.1-280, I.2-82, I.2-84, I.1-316, I.1-15 356, I.1-338, I.1-348, I.1-337, I.1-347, I.1-346, I.1-345, I.2-103, I.1-371, I.1-412, I.2-122, I.2-123, I.2- 125, I.1-418, I.1-422, I.2-156, I.1-431, I.1-433, I.1-434, I.1-437, I.2-167, I.1-439, I.1-441, I.1-445, I.2- 182, I.1-451, I.1-458, I.1-464, I.1-558, I.1-557, I.1-556, I.1-495, I.1-496, I.1-497, I.1-512, I.1-513. Furthermore, the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-20, I.1-18, I.1-35, I.1-40, I.1-50, I.1-68, I.1-70, I.1-80, I.1-93, I.1-145, I.2-1, I.1-152, I.1-153, I.2-10, I.1-174, I.1-178, I.2-29, I.2-41, I.2-82, I.2-84, I.1-316, I.1-338, I.1-348, I.1-337, I.1-347, I.1-346, I.1-345, I.1-371, I.2-123, I.2-125, I.1-418, I.1-431, I.1-433, I.1-434, I.1-435, I.1-437, I.2-167, I.1-439, I.1-441, I.2-182, I.1-458, I.1-464, I.1-470, I.1-558, I.1-557, I.1-556, I.1-495, I.1-496, I.1-497, I.1-513. 25 A5. Efficacy against DIPTE: In this test, for example, the following compounds according to the invention showed very good herbicidal activity (80% to 100%) at an application rate of 1900 g of active substance per hectare: I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-40, I.1-47, I.1-49, I.1-50, I.1-52, I.1-108, I.1-152, I.1-153, I.2-7, I.1-155, I.1-156, I.2-6, I.2-10, I.2-13, I.2-15, I.1-177, I.2-32, I.2-27, I.2-29, I.1-202, I.1-203, I.1-206, I.1-210, I.1-212, I.1-213, I.3-13, I.1-259, I.1-270, I.2-43, 30 I.1-291, I.1-294, I.2-60, I.2-64, I.2-66, I.2-72, I.2-82, I.2-84, I.1-316, I.1-355, I.1-334, I.1-348, I.1-322, I.1-337, I.1-347, I.1-346, I.1-336, I.1-325, I.1-328, I.1-323, I.2-90, I.1-361, I.1-362, I.1-340, I.1-341, I.1-345, I.2-103, I.2-104, I.2-108, I.2-109, I.1-378, I.1-379, I.2-111, I.1-389, I.1-393, I.1-394, I.1-396, I.1- 397, I.1-398, I.1-399, I.1-400, I.1-401, I.2-121, I.2-122, I.2-123, I.2-125, I.1-418, I.1-419, I.1-420, I.2- 156, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.1-438, I.2-167, I.2-169, I.2-170, I.2-173, I.2-35 174, I.2-176, I.1-443, I.1-445, I.2-182, I.1-448, I.1-450, I.1-451, I.2-187, I.2-189, I.2-191, I.1-470, I.1-558, I.1-557, I.1-556, I.1-483, I.1-484, I.1-492, I.1-493, I.1-495, I.1-496, I.1-508, I.1-511, I.1-512, I.1-513, I.1-515, I.1-517. The following compounds according to the invention also had very good BCS241005-Ausland STR 281 herbicidal effect (> 80%) at an application rate of 950 g of active substance per hectare: I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-26, I.1-29, I.1-40, I.1-47, I.1-49, I.1-50, I.1-153, I.2-7, I.1-155, I.2-10, I.2-27, I.1-203, I.1-210, I.1-212, I.1-213, I.3-13, I.1-291, I.1-294, I.2-66, I.2-82, I.2-84, I.1-316, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-336, I.1-325, I.1-323, I.1-361, I.1-362, I.1-340, I.1-341, I.1-5 345, I.2-103, I.2-104, I.2-108, I.1-394, I.1-397, I.1-401, I.2-122, I.2-123, I.2-125, I.1-420, I.2-156, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.1-438, I.2-165, I.2-167, I.2-170, I.2-176, I.1-443, I.2-181, I.2-182, I.1-451, I.2-187, I.1-470, I.1-558, I.1-557, I.1-556, I.1-495, I.1-508, I.1-512, I.1-513, I.1-515. The following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-14, I.1-16, I.1-18, I.1-20, I.1-1021, I.1-22, I.1-40, I.1-50, I.1-145, I.1-155, I.2-27, I.1-203, I.1-212, I.1-294, I.2-82, I.2-84, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-323, I.1-329, I.1-362, I.1-340, I.1-345, I.2-103, I.2-104, I.1-404, I.2-122, I.2-123, I.2-125, I.1-418, I.1-419, I.2-156, I.1-431, I.1-433, I.1-434, I.1-437, I.1-438, I.1-443, I.2-181, I.2-182, I.1-451, I.1-558, I.1-557, I.1-556, I.1-495, I.1-513. Furthermore, the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-14, I.1-16, I.1-20, I.1-21, I.1-22, I.1-50, I.1-155, I.1-203, I.2-82, I.1-348, I.1-347, I.1-346, I.2-103, I.2-122, I.2-123, I.2-125, I.1-418, I.1-433, I.1-434, I.1-437, I.1-443, I.2-182, I.1-556. A6. Efficacy against MATCH: In this test, for example, the following 20 compounds according to the invention showed very good herbicidal activity (80% to 100%) at an application rate of 1900 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-293, I.1-218, I.1-223, I.1-36, I.1-38, I.1-40, I.1-48, I.1-50, I.1-53, I.1-66, I.1-68, I.1-70, I.1-80, I.1-95, I.2-1, I.1-152, I.1-153, I.1-156, I.1-157, I.1-158, I.2-6, I.2-13, I.2-15, I.2-17, I.1-177, I.2-21, I.2-25, I.2-27, I.2-29, I.1-185, I.1-192, I.1-195, I.1-203, I.1-200, I.1-201, I.1-206, I.1-212, I.1-213, I.3-14, I.3-10,25 I.1-258, I.1-259, I.2-37, I.1-260, I.1-264, I.1-270, I.2-41, I.1-272, I.1-274, I.1-281, I.1-284, I.1-285, I.1-287, I.1-291, I.1-294, I.2-70, I.2-73, I.2-82, I.1-315, I.2-95, I.2-99, I.1-355, I.1-356, I.1-334, I.1-338, I.1-348, I.1-337, I.1-335, I.1-347, I.1-346, I.1-326, I.1-359, I.1-323, I.2-93, I.2-90, I.1-361, I.1-362, I.1-363, I.1-339, I.1-340, I.1-341, I.1-342, I.1-343, I.1-345, I.2-103, I.1-368, I.1-369, I.1-370, I.1-371, I.2-107, I.2-108, I.2-110, I.1-374, I.1-376, I.1-377, I.1-378, I.1-380, I.1-381, I.2-113, I.1-389, I.1-393, I.1-394, 30 I.1-396, I.1-397, I.1-398, I.1-399, I.1-400, I.1-401, I.2-117, I.1-404, I.1-405, I.1-407, I.1-412, I.1-413, I.2-121, I.2-122, I.2-123, I.2-124, I.2-125, I.2-127, I.2-135, I.2-137, I.2-138, I.2-141, I.2-145, I.1-418, I.1-419, I.1-420, I.1-421, I.1-422, I.1-427, I.2-155, I.2-156, I.1-428, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.2-162, I.1-435, I.1-436, I.1-437, I.1-438, I.2-167, I.2-168, I.2-169, I.2-170, I.1-439, I.1-441, I.2-171, I.2-173, I.2-176, I.2-177, I.1-443, I.1-445, I.2-181, I.2-182, I.1-446, I.2-184, I.1-448, I.1-449, 35 I.1-450, I.1-451, I.2-187, I.2-189, I.1-453, I.2-191, I.1-454, I.1-456, I.1-458, I.1-459, I.1-460, I.1-464, I.1-466, I.1-471, I.1-558, I.1-557, I.1-556, I.1-472, I.1-478, I.1-483, I.1-484, I.1-485, I.1-486, I.1-493, I.1-494, I.1-495, I.1-496, I.1-497, I.2-206, I.2-207, I.2-209, I.1-504, I.1-508, I.1-510, I.1-513, I.1-515, BCS241005-Abroad STR 282 I.1-516, I.2-211, I.1-517. The following compounds according to the invention also exhibited very good herbicidal activity (> 80%) at an application rate of 950 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-17, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-38, I.1-40, I.1-50, I.1-53, I.1-68, I.1-80, I.1-142, I.1-145, I.1-150, I.2-1, I.1-152, I.1-153, I.1-156, I.1-157, I.1-158, I.2-6, I.2-13, I.1-177, 5 I.2-25, I.2-27, I.2-29, I.1-196, I.1-202, I.1-203, I.1-200, I.1-201, I.1-212, I.1-213, I.3-14, I.3-13, I.1-259, I.2-37, I.1-264, I.1-270, I.2-43, I.2-41, I.1-272, I.1-274, I.1-291, I.2-73, I.2-75, I.2-82, I.1-308, I.2-95, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-326, I.1-359, I.1-323, I.2-93, I.2-90, I.1-361, I.1-362, I.1-363, I.1-341, I.1-342, I.1-345, I.2-103, I.2-104, I.1-371, I.2-109, I.1-376, I.1-395, I.1-396, I.1-397, I.1-398, I.1-399, I.1-400, I.1-401, I.1-412, I.1-413, I.2-121, I.2-122, I.2-123, I.2-125, I.2-138, I.2-10 141, I.1-418, I.1-420, I.1-422, I.1-427, I.2-155, I.2-156, I.1-428, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-436, I.1-437, I.1-438, I.2-167, I.2-168, I.2-169, I.2-170, I.1-441, I.2-172, I.2-173, I.2-176, I.1-443, I.1-445, I.2-181, I.2-182, I.1-448, I.1-449, I.1-450, I.1-451, I.1-453, I.2-191, I.1-454, I.1-458, I.1-459, I.1-460, I.1-462, I.1-464, I.1-466, I.1-471, I.1-558, I.1-557, I.1-556, I.1-472, I.1-478, I.1-483, I.1-484, I.1-485, I.1-487, I.1-493, I.1-494, I.1-495, I.1-496, I.1-497, I.1-508, I.1-513, I.1-515, I.1- 15 517. The following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-18, I.1-19, I.1-20, I.1-21, I.1-22, I.1-35, I.1-38, I.1-40, I.1-47, I.1-50, I.1-53, I.1-68, I.1-145, I.1-150, I.1-155, I.2-13, I.2-25, I.2-27, I.2-29, I.1-196, I.1-200, I.1-201, I.1-206, I.1-210, I.1-212, I.1-213, I.1-259, I.2-37, I.1-270, I.1-272, I.1-274, I.2-75, I.2-82, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-20 359, I.1-323, I.1-361, I.1-363, I.1-339, I.1-345, I.2-103, I.1-371, I.1-397, I.1-398, I.1-400, I.1-401, I.1-412, I.2-121, I.2-123, I.2-125, I.1-420, I.1-422, I.2-156, I.1-430, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-167, I.2-169, I.2-170, I.1-443, I.2-181, I.1-448, I.1-449, I.1-453, I.2-191, I.1-454, I.1-458, I.1-459, I.1-460, I.1-464, I.1-466, I.1-470, I.1-558, I.1-557, I.1-556, I.1-483, I.1-484, I.1-485, I.1-494, I.1-495, I.1-496, I.1-497, I.1-513, I.1-515, I.1-517. Furthermore, the following 25 compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-14, I.1-16, I.1-18, I.1-20, I.1-21, I.1-22, I.1-38, I.1-50, I.1-152, I.1-155, I.2-29, I.1-203, I.1-201, I.1-212, I.1-213, I.2-82, I.1-334, I.1-338, I.1-348, I.1-347, I.1-346, I.1-323, I.1-361, I.1-363, I.1-345, I.2-109, I.1-397, I.1-400, I.1-401, I.2-125, I.1-420, I.2-156, I.1-432, I.1-433, I.1-434, I.1-435, I.1-436, I.1-437, I.1-438, I.2-167, I.2-170, I.1-445, I.1-448, I.1-449, I.2-191, I.1-30 464, I.1-466, I.1-470, I.1-558, I.1-557, I.1-556, I.1-484, I.1-495, I.1-496, I.1-513, I.1-515. A7. Efficacy against STEME: In this test, for example, the following compounds according to the invention had a very good herbicidal effect (80% to 100%) at an application rate of 1900 g of active substance per hectare: I.1-6, I.1-12, I.1-14, I.1-16, I.1-20, I.1-21, I.1-22, I.1-70, I.1-80, I.1-84, I.1-35, I.2-5, I.2-7, I.1-156, I.2-32, I.2-27, I.3-14, I.2-38, I.2-40, I.2-37, I.2-41, I.2-60, I.2-82, I.2-85, I.1-316, I.1-319, I.1-348, I.1-337, I.1-347, I.1-346, I.1-357, I.1-358, I.1-359, I.2-91, I.1-341, I.2-104, I.1-377, I.1-378, I.1-398, I.1-401, I.1-420, I.1-422, I.2-156, I.1-433, I.1-434, I.1-437, I.2-170, I.1-441, I.2- BCS241005-Abroad STR 283 174, I.2-182, I.2-191, I.1-458, I.1-470, I.1-557, I.1-556, I.1-495, I.2-209, I.2-211. The following compounds according to the invention also exhibited very good herbicidal activity (> 80%) at an application rate of 950 g of active substance per hectare: I.1-16, I.1-18, I.1-22, I.1-29, I.1-40, I.1-49, I.1-50, I.1-80, I.1-93, I.2-7, I.1-177, I.2-32, I.2-27, I.1-184, I.3-14, I.1-260, I.1-316, I.1-348, I.1-337, I.1-347, I.1-346, I.1-339, I.1-341, I.2-104, I.1-398, I.1-401, I.2-156, I.2-177, I.2-182, I.2-191, I.1-454, I.1-557, I.2-209, I.1-515. The following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 475 g of active substance per hectare: I.1-21, I.1-93, I.1-177, I.2-32, I.2-27, I.1-316, I.1-348, I.1-347, I.1-346, I.1-401, I.2-156, I.1-437, I.2-182, I.2-191, I.1-513. Furthermore, the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-16, I.1-21, I.1-50, I.1-348, I.1-347, I.2-156, I.2-182, I.1-495. A8. Efficacy against VERPE: In this test, for example, the following compounds according to the invention showed very good herbicidal activity (80% to 100%) at an application rate of 1900 g of active substance per hectare: I.1-6, I.1-9, I.1-12, I.1-14, I.1-16, I.1-21, I.1-22, I.1-47, I.1-66, I.1-68, I.1-80, I.1-86, I.1-93, I.1-145, I.1-149, I.1-152, I.2-7, I.1-155, I.1-156, I.1-157, I.1-158, I.1-255, I.1-169, I.1-177, I.2-20, I.1-178, I.2-25, I.2-32, I.2-27, I.2-29, I.3-13, I.1-203, I.1-200, I.1-201, I.1-207, I.1-212, I.1-213, I.3-10, I.3-13, I.1-259, I.2-41, I.1-272, I.1-291, I.1-294, I.2-72, I.2-83, I.2-84, I.1-309, I.1-316, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-336, I.1-324, I.1-323, I.2-93, I.2-90, I.1-361, I.1-362, 20 I.1-340, I.1-341, I.1-345, I.2-104, I.1-371, I.2-108, I.2-110, I.1-376, I.1-379, I.1-383, I.1-385, I.2-113, I.1-389, I.1-394, I.1-397, I.1-399, I.1-400, I.1-401, I.2-121, I.2-123, I.2-125, I.2-132, I.2-137, I.1-418, I.1-419, I.1-420, I.1-422, I.1-427, I.2-156, I.1-428, I.1-430, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.1-438, I.2-169, I.2-170, I.1-439, I.1-441, I.2-173, I.2-174, I.2-176, I.2-177, I.1-443, I.2-181, I.2-182, I.1-446, I.1-448, I.1-449, I.1-450, I.1-451, I.2-186, I.2-192, I.1-458, I.1-464, I.1-558, I.1-557, I.1-556, 25 I.1-478, I.1-483, I.1-484, I.1-491, I.1-494, I.1-495, I.1-513, I.2-211, I.1-517. The following compounds according to the invention also exhibited very good herbicidal activity (> 80%) at an application rate of 950 g of active substance per hectare: I.1-6, I.1-9, I.1-12, I.1-14, I.1-16, I.1-17, I.1-21, I.1-47, I.1-68, I.1-80, I.1-93, I.1-145, I.1-153, I.1-155, I.1-157, I.1-158, I.2-10, I.2-13, I.1-255, I.1-169, I.1-177, I.2-20, I.2-25, I.2-27, I.2-29, I.1-203, I.1-212, I.1-213, I.1-259, I.2-47, I.1-272, I.2-79, I.2-84,30 I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-324, I.1-359, I.1-323, I.2-90, I.1-361, I.1-340, I.1- 341, I.1-345, I.2-104, I.1-371, I.2-108, I.1-400, I.2-121, I.2-123, I.2-125, I.1-418, I.1-422, I.2-156, I.1-431, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-167, I.2-169, I.2-170, I.1-439, I.2-173, I.2-174, I.2-176, I.1-443, I.1-445, I.2-181, I.2-182, I.1-448, I.1-450, I.1-451, I.2-185, I.1-454, I.1-458, I.1-463, I.1-558, I.1-557, I.1-556, I.1-484, I.1-513. The following compounds according to the invention showed a very good herbicidal effect (> 80%) at an application rate of 475 g of active substance per hectare: I.1-6, I.1-12, I.1-21, I.1-93, I.1-145, I.1-153, I.1-155, I.1-157, I.1-158, I.2-13, I.1-177, I.2-25, I.2-27, I.2-29, I.1-203, I.1-212, I.1-213, I.2-82, I.2-84, I.1-356, I.1-334, I.1-348, I.1-337, I.1-347, I.1-346, I.1-361, BCS241005-Foreign STR 284 I.1-341, I.1-345, I.1-371, I.2-108, I.1-400, I.1-422, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-169, I.1-439, I.2-176, I.1-443, I.2-181, I.2-182, I.1-448, I.1-451, I.1-454, I.1-458, I.1-558, I.1-557, I.1-556, I.1-495, I.1-513. Furthermore, the following compounds according to the invention showed very good herbicidal activity (> 80%) at an application rate of 238 g of active substance per hectare: I.1-12, I.1-521, I.1-93, I.1-155, I.1-157, I.1-177, I.1-203, I.1-212, I.1-348, I.1-337, I.1-347, I.1-346, I.1-341, I.1-345, I.1-400, I.2-123, I.1-422, I.1-432, I.1-433, I.1-434, I.1-435, I.1-437, I.2-169, I.2-181, I.2-182, I.1-448, I.1-451, I.2-191, I.1-458, I.1-558, I.1-557, I.1-556, I.1-495, I.1-513. As the results listed above show, compounds according to the invention exhibit good herbicidal efficacy against weeds when treated 10 in early post-emergence. For example, compounds I.1-12, I.1-16, I.1-21, I.2-1, I.2-27, and I.2-29 exhibit very good herbicidal activity (80% to 100% herbicidal activity) against weeds such as Agrostis tenuis, Diplotaxis muralis, Diplotaxis tenuis, Lolium perenne, Matricaria chamomilla, Poa annua, Setaria viridis, Stellaria media, and Veronica persica in the post-emergence application method described above, at application rates of 15, 1900, 950, 475, and 238 g of active substance per hectare, respectively. B. Pre-emergence herbicide activity – Part I: Seeds of monocotyledonous and dicotyledonous weeds are sown in plastic pots in sandy loam soil (double sowings with one species of monocotyledonous or dicotyledonous weed per pot) and covered with soil. The compounds according to the invention, formulated as wettable powders (WP) or as emulsion concentrates (EC), are then applied to the surface of the cover soil as an aqueous suspension or emulsion, with the addition of 0.5% additive, at a water volume of approximately 600 liters per hectare. After treatment, the pots are placed in greenhouse 25 and kept under good growing conditions for the test plants. After approximately 3 weeks, the effect of the preparations is visually assessed in percentage terms in comparison to untreated controls. For example, 100% effect means plants have died, 0% effect means the same as the control plants. 30 In Tables B1 to B12 below, the effects of selected compounds of the general formula (I) according to Tables I.1 to I.3 on various weeds and an application rate corresponding to 1280 g/ha and lower, obtained according to the aforementioned experimental procedure, are shown. 35 BCS241005-Abroad STR 285 Table B1: Pre-emergence efficacy at an application rate of 1280 g/ha against ABUTH in % ``` Table B2: Pre-emergence efficacy at an application rate of 1280 or 320 g/ha against ALOMY in % ```5 Table B3a: Pre-emergence efficacy at an application rate of 1280 g/ha against DIGSA in % Table B3b: Pre-emergence efficacy at an application rate of 320 g/ha against DIGSA in % BCS241005-Abroad STR 286 Table B3c: Pre-emergence efficacy at an application rate of 80 g/ha against DIGSA in % ```Table B4a: Pre-emergence efficacy at an application rate of 1280 g/ha against ECHCG in % 5 Table B4b: Pre-emergence efficacy at an application rate of 320 g/ha against ECHCG in % Table B5a: Pre-emergence efficacy at an application rate of 1280 g/ha against LOLRI in % Table B5b: Pre-emergence efficacy at an application rate of 320 g/ha against LOLRI in % BCS241005-Abroad STR 287 ``` Table B5c: Pre-emergence efficacy at an application rate of 80 g/ha against LOLRI in % Table B6a: Pre-emergence efficacy at an application rate of 1280 g/ha against MATIN in % 5 Table B6b: Pre-emergence efficacy at an application rate of 320 g/ha against MATIN in % BCS241005-Abroad STR 288 Table B6c: Pre-emergence effect at an application rate of 80 g/ha against MATIN in % ``` Table B7a: Pre-emergence efficacy at an application rate of 1280 g/ha and against POAAN in % ...5 Table B7b: Pre-emergence efficacy at an application rate of 320 g/ha against POAAN in % Table B7c: Pre-emergence efficacy at an application rate of 80 g/ha against POAAN in % BCS241005-Abroad STR 289 Table B8a: Pre-emergence efficacy at an application rate of 1280 g/ha against SETVI in % ```Table B8b: Pre-emergence efficacy at an application rate of 320 g/ha against SETVI in % 5 Table B8c: Pre-emergence efficacy at an application rate of 80 g/ha against SETVI in % Table B9a: Pre-emergence efficacy at an application rate of 1280 g/ha against STEME in % BCS241005-Abroad STR 290 Table B9b: Pre-emergence efficacy at an application rate of 320 g/ha against STEME in % ``` Table B10: Pre-emergence efficacy at an application rate of 1280 g/ha against AMARE in % 5 Table B11a: Pre-emergence efficacy at an application rate of 1280 g/ha against VERPE in % Table B11b: Pre-emergence efficacy at an application rate of 1280 g/ha against VERPE in % BCS241005-Abroad STR 291 Table B12a: Pre-emergence efficacy at application rates of 1280 g/ha and 320 g/ha against KCHSC in % ``` As the results show, compounds according to the invention, such as the five compounds Nos. I.1-6, I.1-21, I.1-29 and other compounds from Tables B1-B12, exhibit good herbicidal efficacy against weeds when applied pre-emergence. For example, compounds Nos. I.1-6, I.1-21, and I.1-29 show very good herbicidal activity (80% to 100% herbicidal efficacy) against weeds such as Abutilon theophrasti, Amaranthus retroflexus, Echinochloa crus-galli, Matricaria inodora, Poa annua, Setaria viridis, and Stellaria media when applied on emergence at an application rate of 1.28 kg/ha. C. Post-emergence Herbicidal Effect – Part I Seeds of monocot and dicot weeds are sown in plastic pots in sandy loam soil (double sowings with one species of monocot and dicot weed per pot), covered with soil, and grown in a greenhouse under controlled growing conditions. Two to three weeks after sowing, the test plants are treated at the one-leaf stage. The compounds according to the invention, formulated as wettable powders (WP) or as emulsion concentrates (EC), are applied to the green parts of the plants as an aqueous suspension or emulsion, with the addition of 0.5% additive, at a water volume of approximately 600 liters per hectare. After approximately three weeks of the test plants remaining in the greenhouse under optimal growing conditions, the effect of the preparations is visually assessed in comparison to untreated controls. For example, 100% effect means plants are dead, 0% effect means the same as the control plants. 25 Tables C1 to C12 below show the effects of selected compounds of general formula (I) according to Tables I.1 to I.3 on various weeds and application rates of 1280 g/ha and lower, obtained according to the aforementioned experimental procedure. 30 BCS241005-Abroad STR 292 Table C1: Post-emergence efficacy at an application rate of 1280 g/ha against ABUTH in % ```Table C2: Post-emergence efficacy at an application rate of 1280 g/ha against ALOMY in % 5 Table C3a: Post-emergence efficacy at an application rate of 1280 g/ha against DIGSA in % Table C3b: Post-emergence efficacy at an application rate of 320 g/ha against DIGSA in % Table C4a: Post-emergence efficacy at an application rate of 1280 g/ha against ECHCG in % 10 BCS241005-Abroad STR 293 Table C4b: Post-emergence efficacy at an application rate of 320 g/ha against ECHCG in % ```Table C5a: Post-emergence efficacy at an application rate of 1280 g/ha against LOLRI in % 5 Table C5b: Post-emergence efficacy at an application rate of 320 g/ha against LOLRI in % Table C6a: Post-emergence efficacy at an application rate of 1280 g/ha against MATIN in % Table C6b: Post-emergence efficacy at an application rate of 320 g/ha against MATIN in % 10 Table C7a: Post-emergence effect at an application rate of 1280 g/ha and against POAAN in % BCS241005-Abroad STR 294 ```Table C7b: Post-emergence efficacy at an application rate of 320 g/ha against POAAN in % Table C7c: Post-emergence efficacy at an application rate of 80 g/ha against POAAN in % 5 Table C8a: Post-emergence efficacy at an application rate of 1280 g/ha against SETVI in % BCS241005-Abroad STR 295 Table C8b: Post-emergence efficacy at an application rate of 320 g/ha against SETVI in % ``` Table C9: Post-emergence efficacy at an application rate of 1280 g/ha against STEME in % 5 Table C10: Post-emergence efficacy at an application rate of 1280 g/ha against AMARE in % Table C11a: Post-emergence efficacy at an application rate of 1280 g/ha against VERPE in % Table C11b: Post-emergence efficacy at an application rate of 1280 g/ha against VERPE in % 10 BCS241005-Abroad STR 296 Table C12: Post-emergence efficacy at application rates of 1280 g/ha and 320 g/ha against KCHSC in % ``` As the results show, compounds according to the invention, such as the five compounds Nos. I.1-6, I.1-21, I.1-22, I.1-29, and other compounds from Tables I.1 to I.3, exhibit good herbicidal efficacy against weeds when applied post-emergence. For example, compounds Nos. I.1-6, I.1-21, I.1-22, and I.1-29 show very good herbicidal activity (80% to 100% herbicidal efficacy) against weeds such as Abutilon theophrasti, Amaranthus retroflexus, Matricaria inodora, Poa annua, and Stellaria media when applied post-emergence at an application rate of 10 to 1.28 kg of active substance or less per hectare. D. Pre-emergence herbicide activity – Part II 15 Seeds of monocot and dicot weeds were placed in plastic or organic plant pots and covered with soil. The compounds according to the invention, formulated as wettable powders (WP) or as emulsion concentrates (EC), were then applied to the surface of the cover soil as an aqueous suspension or emulsion with the addition of 0.5% additive and a water volume equivalent to 600 l/ha. After treatment, the 20 pots were placed in the greenhouse and kept under good growing conditions for the test plants. After approximately 3 weeks, the effect of the preparations was visually assessed in comparison to untreated controls as a percentage. For example, 100% effect means plants have died, 0% effect means the same as the control plants. 25 In the following Tables D1 to D15, the effects of selected compounds of the general formula (I) according to Tables I.1 to I.3 on various weeds and cultivated plants and an application rate corresponding to 1280 g/ha or lower, obtained according to the aforementioned experimental procedure, are presented. 30 BCS241005-Abroad STR 297 Table D1a: Pre-emergence efficacy at an application rate of 1280 g/ha against ABUTH in % ```Table D1b: Pre-emergence efficacy at an application rate of 320 g/ha against ABUTH in % 5 Table D2a: Pre-emergence efficacy at an application rate of 1280 g/ha against ALOMY in % BCS241005-Abroad STR 298 Table D2b: Pre-emergence efficacy at an application rate of 320 g/ha against ALOMY in % Table D2c: Pre-emergence efficacy against ALOMY at an application rate of 80 g/ha in % BCS241005-Abroad STR 299 Table D3a: Pre-emergence efficacy at an application rate of 1280 g/ha against AMARE in % Table D3b: Pre-emergence efficacy at an application rate of 320 g/ha against AMARE in % BCS241005-Abroad STR 300 ```Table D3c: Pre-emergence efficacy at an application rate of 80 g/ha against AMARE in % Table D4a: Pre-emergence efficacy at an application rate of 1280 g/ha against AVEFA in % 5 Table D4b: Pre-emergence efficacy at an application rate of 320 g/ha against AVEFA in % BCS241005-Abroad STR 301 Table D5a: Pre-emergence efficacy at an application rate of 1280 g/ha against DIGSA in % Table D5b: Pre-emergence efficacy at an application rate of 320 g/ha against DIGSA in % BCS241005-Abroad STR 302 Table D5c: Pre-emergence efficacy at an application rate of 80 g/ha against DIGSA in % Table D6a: Pre-emergence efficacy at an application rate of 1280 g/ha against ECHCG in % BCS241005-Abroad STR 303 ```Table D6b: Pre-emergence efficacy at an application rate of 320 g/ha against ECHCG in % Table D6c: Pre-emergence efficacy at an application rate of 80 g/ha against ECHCG in % 5 Table D7a: Pre-emergence efficacy at an application rate of 1280 g/ha against LOLRI in % BCS241005-Abroad STR 304 Table D7b: Pre-emergence efficacy at an application rate of 320 g/ha against LOLRI in % BCS241005-Abroad STR 305 Table D7c: Pre-emergence efficacy at an application rate of 80 g/ha against LOLRI in % Table D8a: Pre-emergence efficacy at an application rate of 1280 g/ha against MATIN in % BCS241005-Abroad STR 306 Table D8b: Pre-emergence efficacy at an application rate of 320 g/ha against MATIN in % BCS241005-Abroad STR 307 Table D8c: Pre-emergence efficacy at an application rate of 80 g/ha against MATIN in % BCS241005-Abroad STR 308 ```Table D9a: Pre-emergence efficacy at an application rate of 1280 g/ha against PHBPU in % Table D9b: Pre-emergence efficacy at an application rate of 320 g/ha against PHBPU in % 5 Table D10a: Pre-emergence efficacy at an application rate of 1280 g/ha against POLCO in % BCS241005-Abroad STR 309 ```Table D10b: Pre-emergence efficacy at an application rate of 320 g/ha against POLCO in % Table D10c: Pre-emergence efficacy at an application rate of 80 g/ha against POLCO in % 5 Table D11a: Pre-emergence efficacy at an application rate of 1280 g/ha against SETVI in % BCS241005-Abroad STR 310 Table D11b: Pre-emergence efficacy at an application rate of 320 g/ha against SETVI in % Table D11c: Pre-emergence efficacy at an application rate of 80 g/ha against SETVI in % BCS241005-Abroad STR 311 Table D12a: Pre-emergence efficacy at an application rate of 1280 g/ha against VERPE in % Table D12b: Pre-emergence efficacy at an application rate of 320 g/ha against VERPE in % BCS241005-Abroad STR 312 Table D12c: Pre-emergence efficacy at an application rate of 80 g/ha against VERPE in % Table D13a: Pre-emergence efficacy against Viotr at an application rate of 1280 g/ha in % BCS241005-Abroad STR 313 Table D13b: Pre-emergence efficacy against Viotr at an application rate of 320 g/ha in % BCS241005-Abroad STR 314 Table D13c: Pre-emergence efficacy against Viotr at an application rate of 80 g/ha in % Table D14a: Pre-emergence efficacy at an application rate of 1280 g/ha against KCHSC in % BCS241005-Abroad STR 315 ```Table D14b: Pre-emergence efficacy at an application rate of 320 g/ha against KCHSC in % Table D14c: Pre-emergence efficacy at an application rate of 80 g/ha against KCHSC in % 5 BCS241005-Abroad STR 316 Table D15a: Pre-emergence efficacy at an application rate of 320 g/ha against AMAPA in % ``` Table D15b: Pre-emergence effect at an application rate of 80 g/ha against AMAPA in % 5 As the results show, compounds of the invention of general formula (I) according to Tables I.1 to I.3 exhibit good herbicidal efficacy against weeds such as Abutilon theophrasti, Alopecurus myosuroides, Amaranthus retroflexus, Digitaria sanguinalis, Echinochloa crus-galli, Lolium rigidum, Matricaria inodora, Pharbitis purpurea, Polygonum convolvulus, Setaria viridis, Veronica persica and Viola tricolor when applied pre-emergence at an application rate of 1280 g of active substance or less per hectare. E. Effect on crops pre-emergence 15 Seeds of mono- or dicotyledonous crops were placed in plastic or organic plant pots and covered with soil. The compounds according to the invention, formulated as wettable powders (WP) or as emulsion concentrates (EC), were then applied to the surface of the cover soil as an aqueous suspension or emulsion with the addition of 0.5% additive and a water volume equivalent to 600 l/ha. After treatment, the 20 pots were placed in the greenhouse and kept under good growing conditions for the test plants. After approximately 3 weeks, the effect of the preparations was visually compared to untreated plants. ``` BCS241005-Abroad STR 317 Controls assessed as percentages. For example, 100% effect = plants died, 0% effect = same as control plants. Tables E1 to E4 below show the effects of selected compounds of the 5 general formula (I) according to Table I.1 on various crops at application rates of 1280 g/ha and below, obtained according to the aforementioned trial procedure. Table E1a: Pre-emergence effect at 1280 g/ha on ZEAMX in % BCS241005-Abroad STR 318 Table E1b: Pre-emergence effect at 320 g/ha on ZEAMX in % BCS241005-Abroad STR 319 Table E1c: Pre-emergence effect at 80 g/ha on ZEAMX in % BCS241005-Abroad STR 320 Table E2a: Pre-emergence effect at 1280 g/ha on TRZAS in % BCS241005-Abroad STR 321 Table E2b: Pre-emergence effect at 320 g/ha on TRZAS in % BCS241005-Abroad STR 322 Table E2c: Pre-emergence effect at 80 g/ha on TRZAS in % BCS241005-Abroad STR 323 Table E3a: Pre-emergence effect at 1280 g/ha on GLXMA in % BCS241005-Abroad STR 324 Table E3b: Pre-emergence effect at 320 g/ha on GLXMA in % BCS241005-Abroad STR 325 BCS241005-Abroad STR 326 Table E3c: Pre-emergence effect at 80 g/ha on GLXMA in % BCS241005-Abroad STR 327 Table E4a: Pre-emergence effect at 1280 g/ha on BRSNW in % BCS241005-Abroad STR 328 ```Table E4b: Pre-emergence effect at 320 g/ha on BRSNW in % 5 BCS241005-Abroad STR 329 Table E4c: Pre-emergence effect at 80 g/ha on BRSNW in % BCS241005-Abroad STR 330 ```As the results show, compounds of the general formula (I) according to the invention exhibit good crop tolerance in organisms such as Zea mays, Brassica napus, Glycine max, and Triticum aestivum when applied pre-emergence at an application rate of 5 to 1280 g or less per hectare. F. Herbicidal effect in post-emergence – Part II Seeds of mono- or dicotyledonous weeds were sown in plastic or wood fiber pots in 10 mm sandy loam soil, covered with soil, and grown in a greenhouse under controlled growing conditions. Two to three weeks after sowing, the experimental plants were treated at the one-leaf stage. The compounds according to the invention, formulated as wettable powders (WP) or as emulsion concentrates (EC), were then sprayed as an aqueous suspension or emulsion with the addition of 0.5% additive at a water volume of approximately 600 l/ha onto the green parts of the plants. After approximately 3 weeks of the experimental plants in the greenhouse under optimal growing conditions, the effect of the preparations was visually assessed in comparison to untreated controls. For example, 100% effect means plants have died, 0% effect means the same as the control plants. Tables F1 to F15 below show the effects of selected compounds of the general formula (I) according to Table I.1 on various weeds at application rates of 1280 g/ha and lower, obtained according to the aforementioned experimental procedure. Tables F1 to F15 below show the effects of selected compounds of the general formula (I) according to Table I.1 on various weeds at application rates of 1280 g/ha and lower, obtained according to the aforementioned experimental procedure. BCS241005-Abroad STR 331 Table F1a: Post-emergence efficacy at an application rate of 1280 g/ha against ABUTH in % Table F1b: Post-emergence efficacy at an application rate of 320 g/ha against ABUTH in % BCS241005-Abroad STR 332 Table F1c: Post-emergence efficacy at an application rate of 80 g/ha against ABUTH in % ```Table F1d: Post-emergence efficacy at an application rate of 20 g/ha against ABUTH in % 5 Table F1e: Post-emergence efficacy at an application rate of 5 g/ha against ABUTH in % Table F1f: Post-emergence efficacy at an application rate of 1.25 g/ha against ABUTH in % Table F2a: Post-emergence efficacy at an application rate of 1280 g/ha against ALOMY in % BCS241005-Abroad STR 333 ```Table F2b: Post-emergence efficacy at an application rate of 320 g/ha against ALOMY in % Table F2c: Post-emergence efficacy at an application rate of 80 g/ha against ALOMY in % 5 Table F3a: Post-emergence efficacy at an application rate of 1280 g/ha against AMARE in % BCS241005-Abroad STR 334 Table F3b: Post-emergence efficacy at an application rate of 320 g/ha against AMARE in % ```Table F3c: Post-emergence effect at an application rate of 80 g/ha against AMARE in % 5 Table F3d: Post-emergence efficacy at an application rate of 20 g/ha against AMARE in % Table F4a: Post-emergence efficacy at an application rate of 1280 g/ha against AVEFA in % ``` BCS241005-Abroad STR 335 ```Table F4b: Post-emergence efficacy at an application rate of 320 g/ha against AVEFA in % Table F4c: Post-emergence efficacy at an application rate of 80 g/ha against AVEFA in % 5 Table F5a: Post-emergence efficacy at an application rate of 1280 g/ha against DIGSA in % BCS241005-Abroad STR 336 ```Table F5b: Post-emergence efficacy at an application rate of 320 g/ha against DIGSA in % Table F5c: Post-emergence efficacy at an application rate of 80 g/ha against DIGSA in % 5 Table F6a: Post-emergence efficacy at an application rate of 1280 g/ha against ECHCG in % BCS241005-Abroad STR 337 ```Table F6b: Post-emergence efficacy at an application rate of 320 g/ha against ECHCG in % Table F6c: Post-emergence efficacy at an application rate of 80 g/ha against ECHCG in % 5 Table F7a: Post-emergence efficacy at an application rate of 1280 g/ha against LOLRI in % BCS241005-Abroad STR 338 ```Table F7b: Post-emergence efficacy at an application rate of 320 g/ha against LOLRI in % Table F7c: Post-emergence effect at an application rate of 80 g/ha against LOLRI in % 5 BCS241005-Abroad STR 339 ``` Table F8b: Post-emergence efficacy at an application rate of 320 g/ha against MATIN in % 5 Table F8c: Post-emergence effect at an application rate of 80 g/ha against MATIN in % BCS241005-Abroad STR 340 Table F8d: Post-emergence efficacy at an application rate of 20 g/ha against MATIN in % ```Table F8e: Post-emergence efficacy at an application rate of 5 g/ha against MATIN in % 5 Table F9a: Post-emergence efficacy at an application rate of 1280 g/ha against PHBPU in % BCS241005-Abroad STR 341 Table F9b: Post-emergence efficacy at an application rate of 320 g/ha against PHBPU in % ```Table F9c: Post-emergence efficacy at an application rate of 80 g/ha against PHBPU in % 5 Table F9d: Post-emergence efficacy at an application rate of 20 g/ha against PHBPU in % Table F9e: Post-emergence efficacy at an application rate of 5 g/ha against PHBPU in % BCS241005-Abroad STR 342 Table F9f: Post-emergence efficacy at an application rate of 1.25 g/ha against PHBPU in % ```Table F10a: Post-emergence efficacy at an application rate of 1280 g/ha against POLCO in % 5 Table F10b: Post-emergence effect at an application rate of 320 g/ha against POLCO in % Table F10c: Post-emergence effect at an application rate of 20 g/ha against POLCO in % Table F10d: Post-emergence effect at an application rate of 5 g/ha against POLCO in % 10 BCS241005-Abroad STR 343 Table F11a: Post-emergence efficacy at an application rate of 1280 g/ha against SETVI in % ```Table F11b: Post-emergence efficacy at an application rate of 320 g/ha against SETVI in % 5 Table F11c: Post-emergence effect at an application rate of 80 g/ha against SETVI in % BCS241005-Abroad STR 344 Table F11d: Post-emergence efficacy at an application rate of 20 g/ha against SETVI in % ```Table F11e: Post-emergence efficacy at an application rate of 5 g/ha against SETVI in % 5 Table F12a: Post-emergence efficacy at an application rate of 1280 g/ha against VERPE in % BCS241005-Abroad STR 345 Table F12b: Post-emergence effect at an application rate of 320 g/ha against VERPE in % BCS241005-Abroad STR 346 Table F12c: Post-emergence effect at an application rate of 80 g/ha against VERPE in % ```Table F12d: Post-emergence efficacy at an application rate of 20 g/ha against VERPE in % 5 Table F12e: Post-emergence efficacy at an application rate of 5 g/ha against VERPE in % BCS241005-Abroad STR 347 Table F12f: Post-emergence effect at an application rate of 1.25 g/ha against VERPE in % ```Table F13a: Post-emergence efficacy against Viotr at an application rate of 1280 g/ha in % 5 Table F13b: Post-emergence efficacy at an application rate of 320 g/ha against Viotr in % BCS241005-Abroad STR 348 Table F13c: Post-emergence efficacy at an application rate of 80 g/ha against Viotr in % Table F13d: Post-emergence efficacy against Viotr at an application rate of 20 g/ha in % BCS241005-Abroad STR 349 ```Table F13e: Post-emergence efficacy against Viotr at an application rate of 5 g/ha in % Table F13f: Post-emergence efficacy against Viotr at an application rate of 1.25 g/ha in % 5 Table F14a: Post-emergence efficacy at an application rate of 1280 g/ha against KCHSC in % BCS241005-Abroad STR 350 Table F14b: Post-emergence efficacy at an application rate of 320 g/ha against KCHSC in % Table F14c: Post-emergence efficacy at an application rate of 80 g/ha against KCHSC in % BCS241005-Abroad STR 351 Table F14d: Post-emergence efficacy at an application rate of 20 g/ha against KCHSC in % ```Table F14e: Post-emergence effect at an application rate of 5 g/ha against KCHSC in % 5 Table F15a: Post-emergence effect at an application rate of 320 g/ha against AMAPA in % Table F15b: Post-emergence effect at an application rate of 20 g/ha against AMAPA in % 10 Table F15c: Post-emergence effect at an application rate of 5 g/ha against AMAPA in % Table F15d: Post-emergence efficacy at an application rate of 1.255 g/ha against AMAPA in % BCS241005-Abroad STR 352 ``` As the results show, compounds of the general formula (I) according to Tables I.1 to I.3 exhibit good herbicidal efficacy against weeds such as Abutilon theophrasti, Alopecurus myosuroides, Amaranthus retroflexus, Digitaria sanguinalis, Echinochloa crus-galli, Lolium rigidum, Matricaria inodora, Pharbitis purpurea, Polygonum convolvulus, Setaria viridis, Veronica persica and Viola tricolor when applied post-emergence at an application rate of 1280 g of active substance or less per hectare. 10. Effect on crops in post-emergence. Seeds of monocot and dicotyledonous crops were sown in plastic or wood fiber pots in sandy loam soil, covered with soil, and cultivated in a greenhouse under controlled growing conditions. Two to three weeks after sowing, the experimental plants were treated at the one-leaf stage. The compounds according to the invention, formulated as wettable powders (WP) or as emulsion concentrates (EC), were then sprayed onto the green parts of the plants as an aqueous suspension or emulsion with the addition of 0.5% additive at a water volume of approximately 600 l/ha. After approximately three weeks of the experimental plants remaining in the greenhouse under optimal growing conditions, the effect of the preparations was visually assessed in comparison to 20 untreated controls. For example, 100% effect means plants have died, 0% effect means the same as the control plants. Tables G1 to G4 below show the effects of selected compounds of general formula (I) according to Table I.1 on various crops at application rates of 1280 g/ha and lower, obtained according to the aforementioned experimental procedure. Table G1a: Post-emergence effect at 1280 g/ha on ZEAMX in % 30 BCS241005-Abroad STR 353 BCS241005-Abroad STR 354 Table G1b: Post-emergence effect at 320 g/ha on ZEAMX in % BCS241005-Abroad STR 355 Table G1c: Post-emergence effect at 80 g/ha on ZEAMX in % BCS241005-Abroad STR 356 ```Table G1d: Post-emergence effect at 20 g/ha on ZEAMX in % 5 Table G1e: Post-emergence effect at 5 g/ha on ZEAMX in % BCS241005-Abroad STR 357 Table G1f: Post-emergence effect at 1.25 g/ha on ZEAMX in % ```5 Table G2a: Post-emergence effect at 1280 g/ha on TRZAS in % BCS241005-Abroad STR 358 Table G2b: Post-emergence effect at 320 g/ha on TRZAS in % BCS241005-Abroad STR 359 Table G2c: Post-emergence effect at 80 g/ha on TRZAS in % BCS241005-Abroad STR 360 ```Table G2d: Post-emergence effect at 20 g/ha on TRZAS in % 5 Table G2e: Post-emergence effect at 5 g/ha on TRZAS in % BCS241005-Abroad STR 361 Table G2f: Post-emergence effect at 1.25 g/ha on TRZAS in % ```5 Table G3a: Post-emergence effect at 1280 g/ha on GLXMA in % BCS241005-Abroad STR 362 Table G3b: Post-emergence effect at 320 g/ha on GLXMA in % BCS241005-Abroad STR 363 Table G3c: Post-emergence effect at 80 g/ha on GLXMA in % BCS241005-Abroad STR 364 Table G3d: Post-emergence effect at 20 g/ha on GLXMA in % BCS241005-Abroad STR 365 ```Table G3e: Post-emergence effect at 5 g/ha on GLXMA in % 5 Table G3f: Post-emergence effect at 1.25 g/ha on GLXMA in % Table G4a: Post-emergence effect at 1280 g/ha on BRSNW in % BCS241005-Abroad STR 366 ```Table G4b: Post-emergence effect at 320 g/ha on BRSNW in % 5 BCS241005-Abroad STR 367 Table G4c: Post-emergence effect at 80 g/ha on BRSNW in % ``` As the results show, compounds of the general formula (I) according to the invention exhibit good crop tolerance in organisms such as Zea mays, Brassica napus, Glycine max and Triticum aestivum when applied post-emergence at an application rate of 1280 g or less per hectare. BCS241005-Abroad STR 368 Insecticidal Efficacy Aphis gossypii – Oral Test 5 Solvent: 100 parts by weight acetone. To prepare a suitable active ingredient solution, 1 part by weight of the active ingredient is mixed with the specified amount of solvent, and the concentrate is diluted with water to the desired concentration. 10 50 µL of the active ingredient solution are placed in microtiter plates, and 150 µL of IPL41 insect medium (33% + 15% sugar) is added to obtain a total volume of 200 µL per well. The plates are then sealed with Parafilm, allowing a mixed population of the cotton aphid (Aphis gossypii) to feed on the active ingredient solution. 15 After 5 days, the mortality is determined as a percentage. 100% means that all aphids were killed, and 0% means that no aphids were killed. In this test, for example, the following compounds from the preparation examples showed a good efficacy of 100% at an application rate of 100 ppm: I.1-48, I.2-27. Myzus persicae - Oral test Solvent: 100 parts by weight acetone. To prepare a suitable active ingredient preparation, 1 part by weight of the active ingredient is mixed with the specified amount of solvent, and the concentrate is diluted with water to the desired concentration. 50 µL of the active ingredient solution are filled into microtiter plates and mixed with 150 µL of IPL41 insect medium (33% + 15% sugar) to obtain a total volume of 200 µL per well. The plates are then sealed with Parafilm, through which a mixed population of the green peach aphid (Myzus persicae) can feed on the active ingredient preparation. After 8 days, mortality is determined as a percentage. 100% means that all aphids were killed, and 0% means that no aphids were killed. In this test, for example, the following 35 compounds from the production examples showed good efficacy of 90% at an application rate of 20 ppm: I.1-176. ``` BCS241005-Abroad STR 369 Spodoptera frugiperda - Spray Test Solvent: 78.0 parts by weight Acetone 1.5 parts by weight Dimethylformamide Emulsifier: Alkylaryl polyglycol ether 5 To prepare a suitable active ingredient preparation, mix 1 part by weight of the active ingredient with the specified amount of solvent and dilute to the desired concentration with water containing an emulsifier concentration of 1000 ppm. Further test concentrations are prepared by dilution with aqueous emulsifier. Spray 10 corn (Zea mays) leaf pieces with an active ingredient preparation of the desired concentration. After drying, infest the leaf pieces with larvae of the fall armyworm (Spodoptera frugiperda). After 7 days, mortality is determined as a percentage. 100% means that all caterpillars were killed and 0% means that no caterpillars were killed. 15 In this test, for example, the following compounds from the preparation examples showed a good efficacy of 100% at an application rate of 100 g/ha: I.2-13. In this test, for example, the following compounds from the preparation examples showed a good efficacy of 100% at an application rate of 20 g/ha: I.1-440, I.2-96, I.2-139. 20 Meloidogyne incognita - Test Solvent: 125.0 parts by weight acetone. To prepare a suitable active ingredient formulation, mix 1 part by weight of active ingredient with the specified amount of solvent and dilute the concentrate with water to the desired concentration. Containers are filled with sand, a solution of the active ingredient, a suspension containing eggs and larvae of the southern root-knot nematode (Meloidogyne incognita), and lettuce seeds. The lettuce seeds germinate, and the seedlings grow. Galls develop on the roots. After 14 days, the nematicidal effect is determined as a percentage based on gall formation. 100% means that no galls were found, and 0% means that the number of galls found on the roots of the 30 treated plants was equal to the number found on the untreated control plants. In this test, for example, the following compounds from the manufacturing examples showed a good effect of 90% at an application rate of 20 ppm: I.1-52. ```

Claims

BCS241005-Ausland STR 370 Ansprüche 1. Verbindungen der allgemeinen Formel (I) oder deren Salze, 5 worin M für eine der Gruppen M-1 M-2 M-3 10 steht, wobei die gestrichelte Linie die Verknüpfungsstelle zum restlichen Teil der Formel (I) kennzeichnet, R1 für Aryl oder Heteroaryl steht, 15 wobei die Aryl- oder Heteroarylgruppe gegebenenfalls weiter substituiert ist durch 1, 2 oder 3 an Ringkohlenstoffatomen gebundene und unabhängig voneinander gewählte Substituenten R4, und wobei gegebenenfalls jeweils zwei benachbarte Substituenten R4 mit den Ringkohlenstoffatomen, an die sie gebunden sind, einen gesättigten, teilgesättigten oder 20 ungesättigten 5- bis 7-gliedrigen, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten Ring bilden können, oder R1 steht für einen fünf- oder sechsgliedrigen Heterocyclyl, der gesättigt oder teilweise gesättigt sein kann, der ein bis vier Heteroatome enthalten kann und der n Oxogruppen trägt, 25 wobei jedes Heteroatom unabhängig voneinander aus einer Gruppe bestehend aus Sauerstoff, Stickstoff und Schwefel gewählt ist, und wobei der Heterocyclylrest optional substituiert ist durch einen, zwei oder drei Substituenten, welche unabhängig voneinander gewählt sind aus BCS241005-Ausland STR 371 einer Gruppe (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C1-C6)-Cycloalkyl, (C1-C6)-Alkoxy, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkoxy, Halogen, Aryl, Heteroaryl, (Heterocyclyl)aryl, 5 R2 für Wasserstoff, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C1-C8)-Cyanoalkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C2-C8)-Alkenyl, (C2-C8)-Haloalkenyl, (C2-C8)-Alkinyl, (C2-C8)-Haloalkinyl, NR11R12, S(O)R14, SO2R14, C(O)OR13, C(O)R13 oder für Aryl-(C1-C8)-alkyl, wobei die Arylgruppe gegebenenfalls weiter 1 bis 5 Substituenten trägt, die unabhängig voneinander für Halogen, Cyano, Nitro, Trimethylsilyl, Pentafluorsulfanyl, -C(=S)NH2, OR13, NR11R12, SR14,10 S(O)R14, SO2R14, C(O)OR13, C(O)R13, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C2-C8)-Alkenyl, (C2-C8)-Haloalkenyl, (C2-C8)-Alkinyl, (C2-C8)-Haloalkinyl, (C3- C8)-Cycanocycloalkyl, (C3-C6)-Halocycloalkyl, (C1-C8)-Haloalkyl, (C1-C8)-Cyanoalkyl steht, oder für Heteroaryl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl steht und wobei Heterocyclyl n Oxogruppen trägt, 15 R3 für (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C2-C8)-Alkenyl, R13O-(C1-C8)-alkyl, (C3-C8)- Cycloalkyl-(C1-C8)-alkyl steht, R4 für Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorsulfanyl, Nitro, Aryldiazo,20 NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1-C8)-alkyl, OSO2-(C1-C8)-haloalkyl, OSO2-(C3-C8)-cycloalkyl, C(O)OR13, C(O)R13, C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C8)-alkyl, R13O-(C1-C8)-alkyl, R14S-(C1- C8)-alkyl, R13(O)C-(C1-C8)-alkyl, (C1-C8)-Alkyl, Cyano-(C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2- C8)-Alkinyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C2-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl,25 (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)- Haloalkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-haloalkyl, (C4-C10)-Cycloalkenyl- (C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C8)- alkyl, Aryl-(C1-C8)-alkinyl, Heteroaryl-(C1-C8)-alkinyl, Heterocyclyl-(C1-C8)-alkinyl, Tris-[(C1-30 C8)-alkyl]silyl-(C2-C8)-alkinyl, Bis-[(C1-C8)-alkyl](aryl)silyl-(C2-C8)-alkinyl, Bis-aryl[(C1-C8)- alkyl]silyl-(C2-C8)-alkinyl, (C3-C8)-Cycloalkyl-(C2-C8)-alkinyl, Aryl-(C2-C8)-alkenyl, Heteroaryl-(C2-C8)-alkenyl, Heterocyclyl-(C2-C8)-alkenyl, (C3-C8)-Cycloalkyl-(C2-C8)-alkenyl, Cyano-(C3-C8)-cycloalkylaminosulfonylamino, Tris-[(C1-C8)-alkyl]silyl, Bis-[(C1-C8)- alkyl](aryl)silyl, Bis-aryl[(C1-C8)-alkyl]silyl steht, wobei Heterocyclyl n Oxogruppen trägt und 35 wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und BCS241005-Ausland STR 372 (C1-C8)-Alkylsulfonyl und wobei Aryl- oder Heteroarylgruppen durch ein oder zwei Alkoxycarbonylgruppen substituiert sein können, R5, R6 unabhängig voneinander für Wasserstoff, Halogen, Cyano, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, 5 (C3-C8)-Cycloalkyl, (C3-C8)-Halocycloalkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, R13O-(C1-C8)- alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, -C=NOR13 stehen, R7 für Wasserstoff, Halogen, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C1-C8)-Alkoxy, (C1-C8)- 10 Haloalkoxy, (C1-C8)-Haloalkyl steht, Q für Hydroxy oder einen Rest der nachfolgenden Formeln Q-1 Q-2 steht, 15 R8 für Wasserstoff, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, (C2-C8)-Alkinyl, (C2-C8)-Alkenyl, C(O)R13, C(O)OR13, (C1-C8)-Alkoxy-(C1-C8)-alkyl steht, R9 für Wasserstoff oder (C1-C8)-Alkyl steht, 20 R10 für Wasserstoff, Halogen, Cyano, NO2, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C3-C8)-Halocycloalkyl, (C3-C8)-Halocycloalkyl-(C1-C8)- alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1- C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, R11R12N-(C1-C8)-alkyl, R13O-(C1-C8)-alkyl, Cyano-(C1-C8)-alkyl, (C1-C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-25 carbonyloxy-(C1-C8)-alkyl, Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy-(C1-C8)- alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- C8)-alkyl, R14(O)S-(C1-C8)-alkyl, R14O2S-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis-[(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, Tris- [(C1-C8)-Alkyl]silyl, Bis-hydroxyboryl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkoxy]boryl-(C1-C8)-alkyl, 30 Tetramethyl-1,3,2-Dioxaborolan-2-yl, Tetramethyl-1,3,2-Dioxaborolan-2-yl-(C1-C8)-alkyl, Nitro-(C1-C8)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1C8)-alkyl, R11R12N(O)C- (C1-C8)-alkyl, Bis-(C1-C8)-alkoxy-(C1-C8)-alkyl steht, wobei Heterocyclyl n Oxogruppen trägt, oder BCS241005-Ausland STR 373 R8 und R10 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, 5 R11 und R12 gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4- C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1- C8)-Alkylthio-(C1-C8)-alkyl, (C1-C8)-Haloalkylthio-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-10 haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C8)- Alkoxycarbonyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-amino- carbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)- alkoxycarbonyl, Heteroaryl-(C1-C8)-alkoxycarbonyl, (C2-C8)-Alkenyloxycarbonyl, (C2-C8)- 15 Alkinyloxycarbonyl, Heterocyclyl-(C1-C8)-alkyl stehen, wobei Heterocyclyl n Oxogruppen trägt, oder R11 und R12 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch weitere Heteroatome unterbrochenen und gegebenenfalls 20 weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R13 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C4-C10)- Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy- 25 (C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy- (C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, Aryl, Aryl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxy- (C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-30 aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Bis-[(C1-C8)- alkyl]amino-(C2-C6)-alkyl, (C1-C8)-Alkyl-amino-(C2C6)-alkyl, Aryl-(C1-C8)-alkylamino-(C2-C6)- alkyl, R14S-(C1-C8)-alkyl, R14(O)S-(C1-C8)-alkyl, R14O2S-(C1-C8)-alkyl, Hydroxycarbonyl-(C1- C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis-[(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, (C1- 35 C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkylcarbonyloxy-(C1-C8)-alkyl, Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy-(C1-C8)-alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, Aryloxy-(C1-C8)-alkyl, Heteroaryloxy-(C1-C8)-alkyl, BCS241005-Ausland STR 374 (C1-C8)-Alkoxycarbonyl steht, wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1-C8)- Alkylsulfonyl, 5 R14 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)- Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl- (C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl, (C3-C8)-10 Cycloalkyl-(C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, Amino, Bis-[(C1-C8)- alkyl]amino, (C1-C8)-Alkyl-amino, Aryl-(C1-C8)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1- C8)-alkyl]amino, (C3-C8)-Cycloalkyl-amino, (C3-C8)-Cycloalkyl-[(C1-C8)-alkyl]amino, N- Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl steht, wobei die zwölf letztgenannten Reste nur an Sulfonylgruppen gebunden sind und wobei Heterocyclyl n Oxogruppen trägt, und 15 wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1-C8)-Alkylsulfonyl, R15 und R16 unabhängig voneinander für (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, Aryl, Heteroaryl, 20 Heterocyclyl stehen, wobei Heterocyclyl n Oxogruppen trägt, oder R15 und R16 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten monocyclischen 3- bis 7-gliedrigen Carbocyclus bilden, 25 R17, R18, R19 und R20 unabhängig voneinander für Wasserstoff, Halogen, (C1-C8)-Alkyl, (C1-C8)-Alkoxy, (C1-C8)-Haloalkoxy, (C3-C8)-Cycloalkyl, (C1-C8)-Haloalkyl stehen, und 30 n für 0, 1 oder 2 steht. 2. Verbindungen der allgemeinen Formel (I) gemäß Anspruch 1, wobei 35 M für eine der Gruppen BCS241005-Ausland STR 375 M-1 M-2 M-3 steht, wobei die gestrichelte Linie die Verknüpfungsstelle zum restlichen Teil der Formel (I) kennzeichnet, 5 R1 für Aryl oder Heteroaryl steht, wobei die Aryl- oder Heteroarylgruppe gegebenenfalls weiter substituiert ist durch 1, 2 oder 3 an Ringkohlenstoffatomen gebundene und unabhängig voneinander gewählte Substituenten R4, und wobei gegebenenfalls jeweils zwei benachbarte Substituenten R4 mit den 10 Ringkohlenstoffatomen, an die sie gebunden sind, einen gesättigten, teilgesättigten oder ungesättigten 5- bis 7-gliedrigen, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten Ring bilden können, oder R1 steht für einen fünf- oder sechsgliedrigen Heterocyclyl, der gesättigt oder teilweise 15 gesättigt sein kann, der ein bis vier Heteroatome enthalten kann und der n Oxogruppen trägt, wobei jedes Heteroatom unabhängig voneinander aus einer Gruppe bestehend aus Sauerstoff, Stickstoff und Schwefel gewählt ist, und wobei der Heterocyclylrest optional substituiert ist durch einen, zwei oder drei Substituenten, welche unabhängig voneinander gewählt sind aus einer Gruppe (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C1-C6)-Cycloalkyl, (C1-C6)-Alkoxy, (C1-C6)- 20 Alkoxy-(C1-C6)-alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkoxy, Halogen, Aryl, Heteroaryl, (Heterocyclyl)aryl; R2 für Wasserstoff, (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C1-C7)-Cyanoalkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C2-C7)-Alkenyl, (C2-C7)-Haloalkenyl, (C2-C7)-Alkinyl, (C2-C7)-Haloalkinyl, 25 NR11R12, S(O)R14, SO2R14, C(O)OR13, C(O)R13 oder für Aryl-(C1-C7)-alkyl, wobei die Arylgruppe gegebenenfalls weiter 1 bis 5 Substituenten trägt, die unabhängig voneinander für Halogen, Cyano, Nitro, Trimethylsilyl, Pentafluorsulfanyl, -C(=S)NH2, OR13, NR11R12, SR14, S(O)R14, SO2R14, C(O)OR13, C(O)R13, (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C2-C7)-Alkenyl, (C2-C7)-Haloalkenyl, (C2-C7)-Alkinyl, (C2-C7)-Haloalkinyl, (C3- 30 C7)-Cycanocycloalkyl, (C3-C7)-Halocycloalkyl, (C1-C7)-Haloalkyl, (C1-C7)-Cyanoalkyl stehen, oder für Heteroaryl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkyl steht und wobei Heterocyclyl n Oxogruppen trägt, BCS241005-Ausland STR 376 R3 für (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C2-C7)-Alkenyl, R13O-(C1-C7)-alkyl, (C3-C7)- Cycloalkyl-(C1-C7)-alkyl steht, 5 R4 für Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorsulfanyl, Nitro, Aryldiazo, NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1-C7)-alkyl, OSO2-(C1-C7)-haloalkyl, OSO2-(C3-C7)-cycloalkyl, C(O)OR13, C(O)R13 C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C7)-alkyl, R13O-(C1-C7)-alkyl, R13S-(C1- C7)-alkyl, R13(O)C-(C1-C7)-alkyl, (C1-C7)-Alkyl, Cyano-(C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2- 10 C7)-Alkinyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C2-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)- Haloalkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-haloalkyl, (C4-C7)-Cycloalkenyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-15 alkyl, Aryl-(C1-C7)-alkinyl, Heteroaryl-(C1-C7)-alkinyl, Heterocyclyl-(C1-C7)-alkinyl, Tris-[(C1- C7)-alkyl]silyl-(C2-C7)-alkinyl, Bis-[(C1-C7)-alkyl](aryl)silyl-(C2-C7)-alkinyl, Bis-aryl[(C1-C7)- alkyl]silyl-(C2-C7)-alkinyl, (C3-C7)-Cycloalkyl-(C2-C7)-alkinyl, Aryl-(C2-C7)-alkenyl, Heteroaryl-(C2-C7)-alkenyl, Heterocyclyl-(C2-C7)-alkenyl, (C3-C7)-Cycloalkyl-(C2-C7)-alkenyl, Cyano-(C3-C7)-Cycloalkylaminosulfonylamino, Tris-[(C1-C7)-alkyl]silyl, Bis-[(C1-C7)- 20 alkyl](aryl)silyl, Bis-aryl[(C1-C7)-alkyl]silyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1-C8)-Alkylsulfonyl und wobei Aryl- oder Heteroarylgruppen durch ein oder zwei Alkoxycarbonylgruppen substituiert sein können, 25 R5, R6 unabhängig voneinander für Wasserstoff, Halogen, Cyano, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, R13O-(C1-C7)- alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, -C=NOR13 stehen, 30 R7 für Wasserstoff, Halogen, (C1-C7)-Alkyl, (C1-C7)-Alkoxy, (C1-C7)-Haloalkoxy, (C3-C7)- Cycloalkyl, (C1-C7)-Haloalkyl steht, Q für Hydroxy oder einen Rest der nachfolgenden Formeln BCS241005-Ausland STR 377 Q-1 Q-2 steht, R8 für Wasserstoff, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, (C2-C7)-Alkinyl, (C2-C7)-Alkenyl, C(O)R13, C(O)OR13, (C1-C7)-Alkoxy-(C1-C7)-alkyl steht, 5 R9 für Wasserstoff oder (C1-C7)-Alkyl steht, R10 für Wasserstoff, Halogen, Cyano, NO2, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C3-C7)-Halocycloalkyl, (C3-C7)-Halocycloalkyl-(C1-C7)-10 alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1- C7)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-alkyl, R11R12N-(C1-C7)-alkyl, R13O-(C1-C7)-alkyl, Cyano-(C1-C7)-alkyl, (C1-C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- carbonyloxy-(C1-C7)-alkyl, Arylcarbonyloxy-(C1-C7)-alkyl, Heteroarylcarbonyloxy-(C1-C7)- alkyl, Heterocyclylcarbonyloxy-(C1-C7)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- 15 C7)-alkyl, R14(O)S-(C1-C7)-alkyl, R14O2S-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, Tris- [(C1-C7)-Alkyl]silyl, Bis-hydroxyboryl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkoxy]boryl-(C1-C7)-alkyl, Tetramethyl-1,3,2-Dioxaborolan-2-yl, Tetramethyl-1,3,2-Dioxaborolan-2-yl-(C1-C7)-alkyl, Nitro-(C1-C7)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1-C7)-alkyl, R11R12N(O)C- 20 (C1-C7)-alkyl, Bis-(C1-C7)-alkoxy-(C1-C7)-alkyl steht und wobei Heterocyclyl n Oxogruppen trägt, oder R8 und R10 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter 25 substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R11 und R12 gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-30 C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1- C7)-Alkylthio-(C1-C7)-alkyl, (C1-C7)-Haloalkylthio-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)- haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C7)- Alkoxycarbonyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl-amino- BCS241005-Ausland STR 378 carbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)- alkoxycarbonyl, Heteroaryl-(C1-C7)-alkoxycarbonyl, (C2-C7)-Alkenyloxycarbonyl, (C2-C7)- Alkinyloxycarbonyl, Heterocyclyl-(C1-C7)-alkyl stehen und wobei Heterocyclyl n Oxogruppen trägt, oder 5 R11 und R12 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, 10 R13 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)- Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)- Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-15 alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, Aryl, Aryl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxy-(C1-C7)- alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C7)- Cycloalkenyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl- aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, Bis-[(C1-C7)- alkyl]amino-(C2-C6)-alkyl, (C1-C7)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C7)-alkyl-amino-(C2-20 C6)-alkyl, R14S-(C1-C7)-alkyl, R14(O)S-(C1-C7)-alkyl, R14O2S-(C1-C7)-alkyl, Hydroxycarbonyl- (C1-C7)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, (C1- C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkylcarbonyloxy-(C1-C7)-alkyl, Arylcarbonyloxy-(C1-C7)-alkyl, Heteroarylcarbonyloxy-(C1-C7)-alkyl, 25 Heterocyclylcarbonyloxy-(C1-C7)-alkyl, Aryloxy-(C1-C7)-alkyl, Heteroaryloxy-(C1-C7)-alkyl, (C1-C7)-Alkoxycarbonyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1- C8)-Alkylsulfonyl, 30 R14 für (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)- Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl- (C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkyl, (C3-C7)-35 Cycloalkyl-(C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, Amino, Bis-[(C1-C7)- alkyl]amino, (C1-C7)-Alkyl-amino, Aryl-(C1-C7)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1- C7)-alkyl]amino; (C3-C7)-Cycloalkyl-amino, (C3-C7)-Cycloalkyl-[(C1-C7)-alkyl]amino, N- BCS241005-Ausland STR 379 Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl steht, wobei die zwölf letztgenannten Reste nur an Sulfonylgruppen gebunden sind und wobei Heterocyclyl n Oxogruppen trägt, und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und 5 (C1-C8)-Alkylsulfonyl, R15 und R16 unabhängig voneinander für (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, Aryl, Heteroaryl, Heterocyclyl stehen und wobei Heterocyclyl n Oxogruppen trägt, oder 10 R15 und R16 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten monocyclischen 3- bis 7-gliedrigen Carbocyclus bilden, R17, R18, R19 und R20 unabhängig voneinander für Wasserstoff, Halogen, (C1-C7)-Alkyl, (C1-C7)-Alkoxy, (C1-C7)-Haloalkoxy, (C3-C7)-Cycloalkyl, (C1-C7)-Haloalkyl stehen 15 und n für 0, 1 oder 2 steht. 20 3. Verbindungen der allgemeinen Formel (I) gemäß Anspruch 1, worin M für eine der Gruppen 25 steht, wobei die gestrichelte Linie die Verknüpfungsstelle zum restlichen Teil der Formel (I) kennzeichnet, R1 für Aryl oder Heteroaryl steht, wobei die Aryl- oder Heteroarylgruppe gegebenenfalls weiter substituiert ist durch 1, 2 30 oder 3 an Ringkohlenstoffatomen gebundene und unabhängig voneinander gewählte Substituenten R4, BCS241005-Ausland STR 380 und wobei gegebenenfalls jeweils zwei benachbarte Substituenten R4 mit den Ringkohlenstoffatomen, an die sie gebunden sind, einen gesättigten, teilgesättigten oder ungesättigten 5- bis 7-gliedrigen, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten Ring bilden können, 5 oder R1 steht für einen fünf- oder sechsgliedrigen Heterocyclyl, der gesättigt oder teilweise gesättigt sein kann, der ein bis vier Heteroatome enthalten kann und der n Oxogruppen trägt, wobei jedes Heteroatom unabhängig voneinander aus einer Gruppe bestehend aus Sauerstoff, Stickstoff und Schwefel gewählt ist, und wobei der Heterocyclylrest optional substituiert ist 10 durch einen, zwei oder drei Substituenten, welche unabhängig voneinander gewählt sind aus einer Gruppe (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C1-C6)-Cycloalkyl, (C1-C6)-Alkoxy, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkoxy, Halogen, Aryl, Heteroaryl, (Heterocyclyl)aryl; 15 R2 für Wasserstoff steht, R3 für (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, R13O-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl steht, 20 R4 für Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorsulfanyl, Nitro, Aryldiazo, NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1-C6)-alkyl, OSO2-(C1-C6)-haloalkyl, OSO2-(C3-C6)-cycloalkyl, C(O)OR13, C(O)R13 C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, R13S-(C1- C6)-alkyl, R13(O)C-(C1-C6)-alkyl, (C1-C6)-Alkyl, Cyano-(C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2- 25 C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)- Haloalkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-haloalkyl, (C4-C6)-Cycloalkenyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-30 alkyl, Aryl-(C1-C6)-alkinyl, Heteroaryl-(C1-C6)-alkinyl, Heterocyclyl-(C1-C6)-alkinyl, Tris-[(C1- C6)-alkyl]silyl-(C2-C6)-alkinyl, Bis-[(C1-C6)-alkyl](aryl)silyl-(C2-C6)-alkinyl, Bis-aryl[(C1-C6)- alkyl]silyl-(C2-C6)-alkinyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkinyl, Aryl-(C2-C6)-alkenyl, Heteroaryl-(C2-C6)-alkenyl, Heterocyclyl-(C2-C6)-alkenyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkenyl, Cyano-(C3-C6)-Cycloalkylaminosulfonylamino, Tris-[(C1-C6)-alkyl]silyl, Bis-[(C1-C6)- 35 alkyl](aryl)silyl, Bis-aryl[(C1-C6)-alkyl]silyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl BCS241005-Ausland STR 381 und (C1-C8)-Alkylsulfonyl und wobei Aryl- oder Heteroarylgruppen durch ein oder zwei Alkoxycarbonylgruppen substituiert sein können, R5, R6 unabhängig voneinander für Wasserstoff, Halogen, (C1-C6)-Alkyl stehen, vorzugsweise jeweils 5 Wasserstoff, R7 für Wasserstoff, Halogen, (C1-C6)-Alkyl, (C1-C7)-Alkoxy, (C1-C7)-Haloalkoxy, (C3-C6)- Cycloalkyl, (C1-C6)-Haloalkyl steht, 10 Q für Hydroxy oder einen Rest der nachfolgenden Formeln Q-1 Q-2 steht, R8 für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, (C2-C6)-Alkinyl, (C2-C6)-Alkenyl, C(O)R13, C(O)OR13, (C1-C6)-Alkoxy-(C1-C6)-alkyl steht, 15 R9 für Wasserstoff oder (C1-C6)-Alkyl steht, R10 für Wasserstoff, Halogen, Cyano, NO2, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Halocycloalkyl-(C1-C6)-20 alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1- C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, R11R12N-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, Cyano-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- carbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)- alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- 25 C6)-alkyl, R14(O)S-(C1-C6)-alkyl, R14O2S-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, Tris- [(C1-C6)-Alkyl]silyl, Bis-hydroxyboryl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkoxy]boryl-(C1-C6)-alkyl, Tetramethyl-1,3,2-Dioxaborolan-2-yl, Tetramethyl-1,3,2-Dioxaborolan-2-yl-(C1-C6)-alkyl, Nitro-(C1-C6)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1-C6)-alkyl, R11R12N(O)C- 30 (C1-C6)-alkyl, Bis-(C1-C6)-alkoxy-(C1-C6)-alkyl steht und wobei Heterocyclyl n Oxogruppen trägt, oder BCS241005-Ausland STR 382 R8 und R10 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, 5 R11 und R12 gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4- C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1- C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-10 haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C6)- Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-amino- carbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)- alkoxycarbonyl, Heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)- 15 Alkinyloxycarbonyl, Heterocyclyl-(C1-C6)-alkyl stehen und wobei Heterocyclyl n Oxogruppen trägt, oder R11 und R12 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter 20 substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R13 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl,25 (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-30 aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)- alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C6)-alkyl-amino-(C2- C6)-alkyl, R14S-(C1-C6)-alkyl, R14(O)S-(C1-C6)-alkyl, R14O2S-(C1-C6)-alkyl, Hydroxycarbonyl- (C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1- 35 C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)-alkyl, BCS241005-Ausland STR 383 (C1-C6)-Alkoxycarbonyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1- C8)-Alkylsulfonyl, 5 R14 für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)- Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1- C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1-10 C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Amino, Bis- [(C1-C6)-alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1-C6)- alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl steht, wobei die zwölf letztgenannten Reste nur an Sulfonylgruppen gebunden sind und wobei Heterocyclyl n 15 Oxogruppen trägt, und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1-C8)-Alkylsulfonyl, R15 und R16 unabhängig voneinander für (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, Aryl, Heteroaryl, 20 Heterocyclyl stehen und wobei Heterocyclyl n Oxogruppen trägt, oder R15 und R16 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten monocyclischen 3- bis 7-gliedrigen Carbocyclus bilden, 25 R17, R18, R19 und R20 unabhängig voneinander für Wasserstoff, Halogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy, (C1-C6)-Haloalkoxy, (C3-C6)-Cycloalkyl, (C1-C6)-Haloalkyl stehen und 30 n für 0, 1 oder 2 steht. 4. Verbindungen der allgemeinen Formel (I) gemäß Anspruch 1, worin M für eine der Gruppen BCS241005-Ausland STR 384 M-1 M-2 M-3 steht, wobei die gestrichelte Linie die Verknüpfungsstelle zum restlichen Teil der Formel (I) kennzeichnet, 5 R1 für Aryl oder Heteroaryl steht, wobei die Aryl- oder Heteroarylgruppe gegebenenfalls weiter substituiert ist durch 1, 2 oder 3 an Ringkohlenstoffatomen gebundene und unabhängig voneinander gewählte Substituenten R4, 10 und wobei gegebenenfalls jeweils zwei benachbarte Substituenten R4 mit den Ringkohlenstoffatomen, an die sie gebunden sind, einen gesättigten, teilgesättigten oder ungesättigten 5- bis 7-gliedrigen, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten Ring bilden können, 15 oder R1 steht für einen fünf- oder sechsgliedrigen Heterocyclyl, der gesättigt oder teilweise gesättigt sein kann, der ein bis vier Heteroatome enthalten kann und der n Oxogruppen trägt, wobei jedes Heteroatom unabhängig voneinander aus einer Gruppe bestehend aus Sauerstoff, Stickstoff und Schwefel gewählt ist, und wobei der Heterocyclylrest optional substituiert ist durch einen, zwei oder drei Substituenten, welche unabhängig voneinander gewählt sind aus20 einer Gruppe (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Cycloalkyl, (C1-C4)-Alkoxy, (C1-C4)- Alkoxy-(C1-C4)-alkyl, (C2-C4)-Alkenyl, (C1-C4)-Haloalkoxy, Halogen, Aryl, Heteroaryl, (Heterocyclyl)aryl; R2 für Wasserstoff steht, 25 R3 für (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, R13O-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl steht, R4 für Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorsulfanyl, Nitro, Aryldiazo,30 NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1C5)-alkyl, OSO2-(C1C5)-haloalkyl, OSO2-(C3C6)-cycloalkyl, C(O)OR13, C(O)R13, C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, R13S-(C1- BCS241005-Ausland STR 385 C6)-alkyl, R13(O)C-(C1-C6)-alkyl, (C1-C6)-Alkyl, Cyano-(C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2- C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)- Haloalkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, 5 (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-haloalkyl, (C4-C6)-Cycloalkenyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C6)- alkyl, Aryl-(C1-C6)-alkinyl, Heteroaryl-(C1-C6)-alkinyl, Heterocyclyl-(C1-C6)-alkinyl, Tris-[(C1- C6)-alkyl]silyl-(C2-C6)-alkinyl, Bis-[(C1-C6)-alkyl](aryl)silyl-(C2-C6)-alkinyl, Bis-aryl[(C1-C6)- alkyl]silyl-(C2-C6)-alkinyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkinyl, Aryl-(C2-C6)-alkenyl, 10 Heteroaryl-(C2-C6)-alkenyl, Heterocyclyl-(C2-C6)-alkenyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkenyl, Cyano-(C3-C6)-Cycloalkylaminosulfonylamino, Tris-[(C1-C6)-alkyl]silyl, Bis-[(C1-C6)- alkyl](aryl)silyl, Bis-aryl[(C1-C6)-alkyl]silyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl 15 und (C1-C8)-Alkylsulfonyl und wobei Aryl- oder Heteroarylgruppen durch ein oder zwei Alkoxycarbonylgruppen substituiert sein können, R5, R6 für Wasserstoff stehen, 20 R7 für Wasserstoff, Halogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy, (C1-C6)-Haloalkoxy, (C3-C6)- Cycloalkyl, (C1-C6)-Haloalkyl steht, Q für Hydroxy oder einen Rest der nachfolgenden Formeln Q-1 Q-2 steht, 25 R8 für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, (C2-C6)-Alkinyl, (C2-C6)-Alkenyl, C(O)R13, C(O)OR13, (C1-C6)-Alkoxy-(C1-C6)-alkyl steht, R9 für Wasserstoff oder (C1-C6)-Alkyl steht, 30 R10 für Wasserstoff, Halogen, Cyano, NO2, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Halocycloalkyl-(C1-C6)- alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1- C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, R11R12N-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, BCS241005-Ausland STR 386 Cyano-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- carbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)- alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- C6)-alkyl, R14(O)S-(C1-C6)-alkyl, R14O2S-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, 5 Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, Tris- [(C1-C6)-Alkyl]silyl, Bis-hydroxyboryl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkoxy]boryl-(C1-C6)-alkyl, Tetramethyl-1,3,2-Dioxaborolan-2-yl, Tetramethyl-1,3,2-Dioxaborolan-2-yl-(C1-C6)-alkyl, Nitro-(C1-C6)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1-C6)-alkyl, R11R12N(O)C- (C1-C6)-alkyl, Bis-(C1-C6)-alkoxy-(C1-C6)-alkyl steht und wobei Heterocyclyl n Oxogruppen 10 trägt, oder R8 und R10 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, 15 R11 und R12 gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4- C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-20 C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C6)- Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-amino- carbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-25 alkoxycarbonyl, Heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)- Alkinyloxycarbonyl, Heterocyclyl-(C1-C6)-alkyl stehen und wobei Heterocyclyl n Oxogruppen trägt, oder R11 und R12 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder 30 teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R13 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, 35 (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)- BCS241005-Ausland STR 387 alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl- aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)- 5 alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C6)-alkyl-amino-(C2- C6)-alkyl, R14S-(C1C6)-alkyl, R14(O)S-(C1C6)-alkyl, R14O2S-(C1-C6)-alkyl, Hydroxycarbonyl- (C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1- C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, 10 Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1- 15 C8)-Alkylsulfonyl, R14 für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)- Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-20 (C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Amino, Bis-[(C1-C6)- alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1- C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1-C6)-alkyl]amino; N- Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl steht, wobei die zwölf letztgenannten 25 Reste nur an Sulfonylgruppen gebunden sind und wobei Heterocyclyl n Oxogruppen trägt, und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1-C8)-Alkylsulfonyl, 30 R15 und R16 unabhängig voneinander für (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, Aryl, Heteroaryl, Heterocyclyl stehen und wobei Heterocyclyl n Oxogruppen trägt, oder R15 und R16 mit dem Kohlenstoffatom, an das sie gebunden sind, einen vollständig gesättigten monocyclischen 3- bis 7-gliedrigen Carbocyclus bilden, 35 R17, R18, R19 und R20 unabhängig voneinander für Wasserstoff, Halogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy, (C1-C8)-Haloalkoxy, (C3-C6)-Cycloalkyl, (C1-C6)-Haloalkyl stehen BCS241005-Ausland STR 388 und n für 0, 1 oder 2 steht. 5 5. Verbindungen der allgemeinen Formel (I) gemäß Anspruch 1, worin M für eine der Gruppen M-1 M-2 M-3 10 steht, wobei die gestrichelte Linie die Verknüpfungsstelle zum restlichen Teil der Formel (I) kennzeichnet, R1 für Phenyl, 2-Methylphenyl, 3-Methylphenyl, 4-Methylphenyl, 2-Trifluormethylphenyl, 3-15 Trifluormethylphenyl, 4-Trifluormethylphenyl, 2-Trifluormethoxyphenyl, 3- Trifluormethoxyphenyl, 4-Trifluormethoxyphenyl, 2-Chlorphenyl, 3-Chlorphenyl, 4- Chlorphenyl, 3-Fluorphenyl, 4-Fluorphenyl, 2-Fluorphenyl, 2-Bromphenyl, 2-Iodphenyl, 3- Bromphenyl, 3-Iodphenyl, 4-Bromphenyl, 4-Iodphenyl, 2-Difluormethylphenyl, 2- Cyanophenyl, 3-Difluormethylphenyl, 3-Cyanophenyl, 4-Difluormethylphenyl, 4-Cyanophenyl, 20 2-Methoxyphenyl, 3-Methoxyphenyl, 4-Methoxyphenyl, 3,4-Difluorphenyl, 2,4-Difluorphenyl, 2,3-Difluorphenyl, 3,5-Difluorphenyl, 2,5-Difluorphenyl, 2,6-Difluorphenyl, 3,4-Dichlorphenyl, 2,4-Dichlorphenyl, 2,3-Dichlorphenyl, 3,5-Dichlorphenyl, 2,5-Dichlorphenyl, 2,6- Dichlorphenyl, 3,4-Dibromphenyl, 2,4-Dibromphenyl, 2,3-Dibromphenyl, 3,5-Dibromphenyl, 2,5-Dibromphenyl, 3,5-Diiodphenyl, 2,4-Diiodphenyl, 2,5-Diiodphenyl, 3,4-Diiodphenyl, 3-25 Fluor-4-chlorphenyl, 2-Fluor-4-chlorphenyl, 2-Fluor-3-chlorphenyl, 2-Fluor-5-chlorphenyl, 3- Fluor-5-chlorphenyl, 2-Fluor-6-chlorphenyl, 3-Fluor-5-bromphenyl, 3-Fluor-5-iodphenyl, 3- Fluor-4-bromphenyl, 3-Fluor-4-iodphenyl, 2-Fluor-4-trifluormethylphenyl, 2-Fluor-4- methylphenyl, 2-Fluor-4-trifluormethoxyphenyl, 2-Fluor-4-trifluormethylsulfanylphenyl, 2- Fluor-4-cyanophenyl, 2-Fluor-4-methoxyphenyl, 2-Fluor-4-methoxycarbonylphenyl, 2-Fluor-4-30 hydroxycarbonylphenyl, 2-Fluor-6-trifluormethylphenyl, 2-Fluor-6-methylphenyl, 2-Fluor-6- trifluormethoxyphenyl, 2-Fluor-6-trifluormethylsulfanylphenyl, 2-Fluor-6-cyanophenyl, 2- Fluor-6-methoxyphenyl, 2-Fluor-6-methoxycarbonylphenyl, 2-Fluor-6-hydroxycarbonylphenyl, BCS241005-Ausland STR 389 3-Fluor-5-methoxycarbonylphenyl, 3-Fluor-5-hydroxycarbonylphenyl, 3-Fluor-5-cyanophenyl, 3-Fluor-5-methoxyphenyl, 3-Chlor-5-methoxyphenyl, 3-Brom-5-methoxyphenyl, 3-Iod-5- methoxyphenyl, 3-Chlor-4-fluorphenyl, 3-Brom-4-fluorphenyl, 3-Iod-4-fluorphenyl, 3-Brom-4- chlorphenyl, 3-Iod-4-chlorphenyl, 3-Iod-4-bromphenyl, 3-Iod-5-bromphenyl, 3-Brom-4- 5 iodphenyl, 4-Brom-3-chlorphenyl, 3-Chlor-4-iodphenyl, 3-Brom-5-chlorphenyl, 3-Chlor-5- iodphenyl, 3-Chlor-5-cyanophenyl, 3-Brom-5-cyanophenyl, 3-Iod-5-cyanophenyl, 2-Chlor-4- fluorphenyl, 2-Chlor-3-fluorphenyl, 2-Chlor-5-fluorphenyl, 3-Chlor-5-cyclopropylphenyl, 3-(1- Chlorcycloprop-1-yl)-5-chlorphenyl, 3-(1-Fluorcycloprop-1-yl)-5-chlorphenyl, 3-(1- Cyanocycloprop-1-yl)-5-chlorphenyl, 3-Cyclopropyl-5-fluorphenyl, 3-(1-Chlorcycloprop-1-yl)-10 5-fluorphenyl, 3-(1-Fluorcycloprop-1-yl)-5-fluorphenyl, 3-(1-Cyanocycloprop-1-yl)-5- fluorphenyl, 3-Cyclopropyl-5-bromphenyl, 3-Cyclopropyl-5-iodphenyl, 3-(1-Chlorcycloprop-1- yl)-5-bromphenyl, 3-(1-Fluorcycloprop-1-yl)-5-bromphenyl, 3-(1-Cyanocycloprop-1-yl)-5- bromphenyl, 3-(1-Cyanocycloprop-1-yl)phenyl, 4-(1-Cyanocycloprop-1-yl)phenyl, 3-(1- Fluorcycloprop-1-yl)-5-iodphenyl, 3-(1-Fluorcycloprop-1-yl)-5-trifluormethylphenyl, 3-(1-15 Fluorcycloprop-1-yl)-5-trifluormethoxyphenyl, 3,4-Dimethylphenyl, 2,4-Dimethylphenyl, 2,3- Dimethylphenyl, 2,5-Dimethylphenyl, 2,6-Dimethylphenyl, 3-Fluor-4-methylphenyl, 3-Fluor-5- methoxyphenyl, 3-Fluor-4-methoxyphenyl, 3-Fluor-5-methylphenyl, 3,5-Dimethylphenyl, 3,5- bis(Trifluormethyl)phenyl, 2,5-bis(Trifluormethyl)phenyl, 2,4-bis(Trifluormethyl)phenyl, 2,6- bis(Trifluormethyl)phenyl, 2,3-bis(Trifluormethyl)phenyl, 3,5-bis(Difluormethyl)phenyl, 3,4-20 bis(Trifluormethyl)phenyl, 3,4-bis(Difluormethyl)phenyl, 2-Trifluormethyl-4-fluorphenyl, 3- Fluor-5-trifluormethylphenyl, 3-Chlor-5-trifluormethylphenyl, 3-Brom-5-trifluormethylphenyl, 3-Iod-5-trifluormethylphenyl, 3-Trifluormethyl-4-iodphenyl, 3-Trifluormethyl-4-bromphenyl, 3- Trifluormethyl-4-trifluormethoxyphenyl, 3-Trifluormethyl-4-difluormethoxyphenyl, 3- Trifluormethyl-4-Cyanophenyl, 3-Trifluormethyl-4-methylphenyl, 3-Trifluormethyl-4-25 fluorphenyl, 3-Brom-4-trifluormethylphenyl, 3-Iod-4-Trifluormethylphenyl, 3-Methoxy-5- trifluormethylphenyl, 3-Methyl-5-trifluormethylphenyl, 3-Chlor-5-methylphenyl, 3-Brom-5- methylphenyl, 3-Iod-5-methylphenyl, 3-Difluormethoxy-5-trifluormethylphenyl, 3- Difluormethoxy-4-trifluormethylphenyl, 3-Difluormethoxy-5-trifluormethoxyphenyl, 3- Difluormethoxy-4-trifluormethoxyphenyl, 3-Difluormethoxyphenyl, 3-Chlor-5-30 difluormethoxyphenyl, 3-Chlor-4-difluormethoxyphenyl, 3-Difluormethoxy-4-chlorphenyl, 3- Brom-5-difluormethoxyphenyl, 3-Brom-4-difluormethoxyphenyl, 3-Difluormethoxy-4- bromphenyl, 3-Fluor-5-difluormethoxyphenyl, 3-Fluor-4-difluormethoxyphenyl, 3- Difluormethoxy-4-fluorphenyl, 3,5-bis(Difluormethoxy)phenyl, 3-Trifluormethoxy-5- trifluormethylphenyl, 4-Chlor-3-trifluormethoxyphenyl, 3-Cyano-5-trifluormethylphenyl, 3-35 Chlor-5-prop-2-ylphenyl, 3-Chlor-5-ethylphenyl, 3-Prop-2-yl-5-trifluormethylphenyl, 3-Ethyl-5- trifluormethylphenyl, 3-Cyclopropyl-5-trifluormethylphenyl, 3-(1-Chlorycloprop-1-yl)-5- trifluormethylphenyl, 3-(1-Fluorycloprop-1-yl)-5-trifluormethylphenyl, 3-(1-Cyanoycloprop-1- BCS241005-Ausland STR 390 yl)-5-trifluormethylphenyl, 2-Chlor-5-trifluormethylphenyl, 2-Chlor-4-trifluormethylphenyl, 3- Chlor-4-trifluormethylphenyl, 2-Chlor-6-trifluormethylphenyl, 2-Trifluormethyl-4-chlorphenyl, 3-Trifluormethyl-4-chlorphenyl, 2,3,4-Trifluorphenyl, 2,3,5-Trifluorphenyl, 3,4,5- Trifluorphenyl, 2,4,5-Trifluorphenyl, 2,3,6-Trifluorphenyl, 2,4,6-Trifluorphenyl, 3,4,5- 5 Trichlorphenyl, 3-Brom-4,5-dichlorphenyl, 3-Fluor-4,5-dichlorphenyl, 4-Brom-3,5- dichlorphenyl, 3,4-Dichlor-5-trifluormethylphenyl, 3,4-Dichlor-5-trifluormethoxyphenyl, 2- Fluor-3-methoxy-4-fluorphenyl, 2,4,6-Trimethylphenyl, 3,4,5-Trimethylphenyl, 2-Fluor-3- methylphenyl, 2-Fluor-6-methylphenyl, 2-Chlor-4,5-difluorphenyl, 2-Chlor-4-fluor-5- nitrophenyl, 2-Fluor-4-nitrophenyl, 2,4-Difluor-3-chlorphenyl, 2-Chlor-3,6-difluorphenyl, 2,3-10 Dichlor-6-fluorphenyl, 2-Chlor-4-cyanophenyl, 2-Ethyl-4,6-dimethylphenyl, 2-Fluor-6- ethoxycarbonylphenyl, 2-Fluor-6-isopropyloxyphenyl, 2,6-Difluor-3-methylphenyl, 2,6-Dichlor- 3-methylphenyl, Pyridin-2-yl, Pyridin-3-yl, 2-Fluorpyridin-3-yl, 2-Chlorpyridin-3-yl, 2,4- Difluorpyridin-3-yl, 2,4-Dichlorpyridin-3-yl, 2,6-Difluorpyridin-3-yl, 2,6-Dichlorpyridin-3-yl, 3,4-Difluorpyridin-2-yl, 3,4-Dichlorpyridin-2-yl, 3,5-Difluorpyridin-2-yl, 3,5-Dichlorpyridin-2-15 yl, 5-Chlorpyridin-2-yl, 6-Chlorpyridin-2-yl, 5-Fluorpyridin-2-yl, 6-Fluorpyridin-2-yl, 5,6- Difluorpyridin-2-yl, 5,6-Dichlorpyridin-2-yl, 4,6-Difluorpyridin-2-yl, 4,6-Dichlorpyridin-2-yl, 2,5-Difluorpyridin-3-yl, 2,5-Dichlorpyridin-3-yl, 4-Fluorpyridin-3-yl, 4-Chlorpyridin-3-yl, 5- Chlorpyridin-3-yl, 5-Brompyridin-3-yl, 4-Trifluormethylpyridin-3-yl, 4-Fluorpyridin-2-yl, 4- Chlorpyridin-2-yl, 4-Methylpyridin-2-yl, 4-Trifluormethylpyridin-2-yl, 4-Methoxypyridin-2-yl,20 4-Trifluormethoxypyridin-2-yl, 5-Trifluormethylpyridin-3-yl, 5-Trifluormethoxypyridin-3-yl, 5- Methoxypyridin-3-yl, 6-Chlorpyridin-3-yl, 6-Brompyridin-3-yl, 6-Trifluormethylpyridin-3-yl, 2- Trifluormethylpyridin-3-yl, 3-Fluor-5-trifluormethoxyphenyl, 3-Chlor-5-trifluormethoxyphenyl, 3-Brom-5-trifluormethoxyphenyl, 3-Iod-5-trifluormethoxyphenyl, 3-Methyl-5- trifluormethoxyphenyl, 3-Cyano-5-trifluormethoxyphenyl, 3-(Prop-2-yl)-5-25 trifluormethoxyphenyl, 3-(Prop-1-yl)-5-trifluormethoxyphenyl, 3-(But-1-yl)-5- trifluormethoxyphenyl, 3-(1,1-Dimethyleth-1-yl)-5-trifluormethoxyphenyl, 3-Vinyl-5- trifluormethoxyphenyl, 3-(Prop-1-en-2-yl)-5-trifluormethoxyphenyl, 3-(Prop-1-en-1-yl)-5- trifluormethoxyphenyl, 3-(1-Methylprop-1-en-1-yl)-5-trifluormethoxyphenyl, 3-Ethyl-5- trifluormethoxyphenyl, 3-Cyclopropyl-5-trifluormethoxyphenyl, 3-Cyclobutyl-5-30 trifluormethoxyphenyl, 3-Cyclopentyl-5-trifluormethoxyphenyl, 3-Cyclopent-1-en-1-yl-5- trifluormethoxyphenyl, 3-trimethylsilyl-5-trifluormethoxyphenyl, 3-(1-Methylprop-1-yl)-5- trifluormethoxyphenyl, 3-(1-Methylprop-2-yl)-5-trifluormethoxyphenyl, 3-(1-Chlorycloprop-1- yl)-5-trifluormethoxyphenyl, 3-(1-Fluorycloprop-1-yl)-5-trifluormethoxyphenyl, 3-(1- Cyanocycloprop-1-yl)-5-trifluormethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-4-35 trifluormethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-5-trifluormethylphenyl, 3-(1- Cyanocycloprop-1-yl)-4-trifluormethylphenyl, 3,5-bis(Trifluormethoxy)phenyl, 3,4- bis(Trifluormethoxy)phenyl, 3-Methoxymethyl-5-trifluormethoxyphenyl, 3,5-Dichlorpyridin-4- BCS241005-Ausland STR 391 yl, 3,5-Difluorpyridin-4-yl, 3,5-Dibrompyridin-4-yl, 3,5-Dimethylpyridin-4-yl, 3,5- bis(trifluormethyl)pyridin-4-yl, 2,6-Dichlorpyridin-4-yl, 2,6-Difluorpyridin-4-yl, 2,6- Dibrompyridin-4-yl, 2,6-Dimethylpyridin-4-yl, 2,6-bis(trifluormethyl)pyridin-4-yl, 2- Chlorpyridin-4-yl, 2-Trifluormethylpyridin-4-yl, 3-Chlorpyridin-4-yl, 3-Trifluormethylpyridin- 5 4-yl, 3-Chlor-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3-Fluor-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3- Brom-5-(pentafluor-λ⁶-sulfanyl)phenyl, 1,3-Benzothiazol-5-yl, 1,3-Benzothiazol-6-yl, 2- Methoxy-1,3-benzothiazol-5-yl, 2-Methyl-1,3-benzothiazol-5-yl, 2-Chlor-1,3-benzothiazol-5-yl, Naphth-2-yl, Naphth-1-yl, 8-Bromnaphth-2-yl, 7-Bromnaphth-2-yl, 6-Bromnaphth-2-yl, 5- Bromnaphth-2-yl, 3-Chlor-5-methylsulfonylphenyl, 3-Chlor-4-(methylsulfonyl)phenyl, 3-Brom-10 5-methylsulfonylphenyl, 3-Brom-4-methylsulfonylphenyl, 3-Methylsulfonyl-4- trifluormethylphenyl, 3-(Methylsulfonyl)-4-chlorphenyl, 4-Brom-3-methylsulfonylphenyl, 3- Chlor-5-(ethylsulfonyl)phenyl, 3-Chlor-5-(prop-2-ylsulfonyl)phenyl, 3-Chlor-5- (cyclopropylsulfonyl)phenyl, 3-Methylsulfonyl-5-trifluormethylphenyl, 3-Methylsulfonyl-5- trifluormethoxyphenyl, 3-Methylsulfonyl-5-(1H-pyrazol-1-yl)phenyl, 3-Methylsulfonyl-5-(1H-15 1,2,4-triazol-1-yl)phenyl, 3-Ethylsulfonyl-5-trifluormethoxyphenyl, 3-Ethylsulfinyl-5- trifluormethoxyphenyl, 3-Ethylsulfanyl-5-trifluormethoxyphenyl, 3-Chlor-5- (methylsulfinyl)phenyl, 3-Chlor-5-(ethylsulfinyl)phenyl, 3-Chlor-5-(prop-2-ylsulfinyl)phenyl, 3- Chlor-5-(cyclopropylsulfinyl)phenyl, 3-(Methylsulfinyl)-5-trifluormethylphenyl, 3- (Methylsulfinyl)-5-trifluormethoxyphenyl, 3-(Methylsulfinyl)-5-(1H-pyrazol-1-yl)phenyl, 3-20 (Methylsulfinyl)-5-(1H-1,2,4-triazol-1-yl)phenyl, 3-Chlor-5-(methylsulfanyl)phenyl, 3-Chlor-5- (ethylsulfanyl)phenyl, 3-Chlor-5-(prop-2-ylsulfanyl)phenyl, 3-Chlor-5- (cyclopropylsulfanyl)phenyl, 3-(Methylsulfanyl)-5-trifluormethylphenyl, 3-(Methylsulfanyl)-5- trifluormethoxyphenyl, 3-(Methylsulfanyl)-5-(1H-pyrazol-1-yl)phenyl, 3-Methylsulfanyl-5-(1H- 1,2,4-triazol-1-yl)phenyl, 2,3-Dihydro-1,4-benzodioxin-6-yl, 1,1,4,4-Tetraoxido-2,3-dihydro-25 1,4-benzodithiin-6-yl, 1,1,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,4,4-Trioxido-2,3- dihydro-1,4-benzodithiin-6-yl, 1,4-Dioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 2,3-dihydro-1,4- benzodithiin-6-yl, 1,1,3,3-Tetraoxido-1,3-benzodithiol-5-yl, 1,1,3-trioxido-1,3-benzodithiol-5- yl, 1,3-dioxido-1,3-benzodithiol-5-yl, 1,3-benzodithiol-5-yl, 2,3-dihydro-1,4-benzoxathiin-6-yl, 2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-dioxido-2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-dioxido-30 2,3-dihydro-1,4-benzoxathiin-6-yl, 3,3-dioxido-1,3-benzoxathiol-5-yl, 3-Oxido-1,3- benzoxathiol-5-yl, 1,3-Benzoxathiol-5-yl, 3,3-dioxido-1,3-benzoxathiol-6-yl, 3-Oxido-1,3- benzoxathiol-6-yl, 1,3-Benzoxathiol-6-yl, 3,5-bis(Methylsulfonyl)phenyl, 3,4- bis(Methylsulfonyl)phenyl, 3,5-bis(Methylsulfanyl)phenyl, 3,4-bis(Methylsulfanyl)phenyl, 3-(4- Chlor-1H-pyrazol-1-yl)phenyl, 3-(4-Brom-1H-pyrazol-1-yl)phenyl, 3-(4-Iod-1H-pyrazol-1-35 yl)phenyl, 3-(4-Methyl-1H-pyrazol-1-yl)phenyl, 3-(4-Trifluormethyl-1H-pyrazol-1-yl)phenyl, 3- (1H-pyrazol-1-yl)phenyl, 3-(1H-pyrazol-1-yl)-5-chlorphenyl, 3-(1H-pyrazol-1-yl)-5- trifluormethylphenyl, 3-(1H-pyrazol-1-yl)-5-trifluormethoxyphenyl, 1,3-Benzodioxol-5-yl, 7- BCS241005-Ausland STR 392 chlor-1,3-benzodioxol-5-yl, 6-chlor-1,3-benzodioxol-5-yl, 5-Methylpyrazin-2-yl, 5- Trifluormethylpyrazin-2-yl, 5-Fluorpyrazin-2-yl, 5-Chlorpyrazin-2-yl, 5-Brompyrazin-2-yl, Pyrazin-2-yl, Pyridazin-4-yl, Pyridazin-3-yl, 2-Methylpyrimidin-5-yl, Pyrimidin-5-yl, 3-Nitro-5- methoxyphenyl, 3-Nitro-4-methoxyphenyl, 3-Chlor-5-nitrophenyl, 3-Chlor-4-nitrophenyl, 3- 5 Nitro-4-chlorophenyl, 2-Nitro-5-trifluormethoxyphenyl, 3-Nitro-5-trifluormethylphenyl, 3- Nitro-4-trifluormethoxyphenyl, 3-Trifluormethyl-4-nitrophenyl, 3-Nitro-5- trifluormethoxyphenyl, 3-Nitrophenyl, 3-Phenyl-5-trifluormethylphenyl, 3- Methoxycarbonylphenyl-5-trifluormethylphenyl, 3,5-bis-(Trifluormethansulfonyl)phenyl, 3- Fluor-5-[(trifluormethyl)sulfonyl]phenyl, 3-Chlor-5-[(trifluormethyl)sulfonyl]phenyl, 3-Brom-5-10 [(trifluormethyl)sulfonyl]phenyl, 3-[(1-Cyanocycloprop-1-yl)-1-sulfonyl]-5- trifluormethoxyphenyl, 3-(1-Carbamoylcyclopropyl)-5-Trifluormethylsulfonylphenyl, 3-(2- Cyanopropyl-2-sulfonyl)-5-trifluormethoxyphenyl, 3-(1-Cyano-1-methyleth-1-yl)-5- trifluormethylsulfonylphenyl, 3-(1-Cyanocycloprop-1-yl)-5-(trifluormethylsulfonyl)phenyl, 3- (1-Cyano-1-methyleth-1-yl)-5-trifluormethylphenyl, 3-(1-Cyano-1-methyl-ethyl)-5-15 trifluormethoxyphenyl, 3-[(Difluormethyl)sulfonyl]-5-trifluormethoxyphenyl, 3,5-bis- (difluormethylsulfonyl)phenyl, 3-(1-Methylsulfonylcyclopropyl)-5-trifluormethoxyphenyl, 3- Cyclopropylsulfamoyl-5-trifluormethoxyphenyl, 3-Methylsulfamoyl-5-trifluormethoxyphenyl, 3-Sulfamoyl-5-trifluormethoxyphenyl, 3-(1-methyl-1-methylsulfonylethyl)-5- trifluormethoxyphenyl, 3-Brom-5-[Brom(difluor)methyl]phenyl, 3-Chlor-5-20 [chlor(difluor)methyl]phenyl, 3-Chlor-5-(2-chlor-1,1,2,2-tetrafluorethoxyphenyl, 3-(1- Methylsulfonylcyclopropyl)-5-trifluormethylphenyl, 3-Chlor-5-[1- (trifluormethyl)cyclopropyl]phenyl, 3-Brom-5-[1-(trifluormethyl)cyclopropyl]phenyl, 3-Bromo- 5-(2,2-dichlorcyclopropyl)phenyl, 3-Chlor-5-(2,2-dichlorcyclopropyl)phenyl, 3-Fluor-5-(2,2- dichlorcyclopropyl)phenyl, 3-Cyclopropylsulfonyl-5-trifluormethoxyphenyl, 3- 25 Cyclobutylsulfonyl-5-trifluormethoxyphenyl, 3-[(Prop-1-yl)sulfonyl]-5-trifluormethoxyphenyl, 3-[Prop-2-ylsulfonyl]-5-trifluormethoxyphenyl, 3-[1-Methyl-1-(methylsulfonyl)ethyl]-5- trifluormethylphenyl, 3-Methylsulfonyl-5-(1,1,2,2-tetrafluorethoxy)phenyl, 3-Brom-5-(1,1,2,2- tetrafluorethoxy)phenyl, 3,5-bis-(1,1,2,2-tetrafluorethoxy)phenyl, 3-(trifluormethoxy)-5- vinylphenyl, 3-formyl-5-trifluormethoxyphenyl, 3-[(Z)-(methoxyimino)methyl]-5-30 trifluormethoxyphenyl, 3-[(E)-(methoxyimino)methyl]-5-trifluormethoxyphenyl, 3-[(Z)- (ethoxyimino)methyl]-5-trifluormethoxyphenyl, 3-[(E)-(ethoxyimino)methyl]-5- trifluormethoxyphenyl, 3-[(Z)-(hydroxyimino)methyl]-5-trifluormethoxyphenyl, 3-[(E)- (hydroxyimino)methyl]-5-trifluormethoxyphenyl, 2-(2,2-Difluorcyclopropyl)phenyl, 2-(2,2- Dibromcyclopropyl)phenyl, 2-(2-Brom-2-Methylcyclopropyl)phenyl, 2-(2-35 Methylencyclopropyl)phenyl, 2-[1,1'-Bi(cyclopropyl)-1-yl]phenyl, 2-(Spiro[2.2]pentan-1- yl)phenyl, 3-(2,2-Difluorcyclopropyl)phenyl, 3-(2-Brom-2-Methylcyclopropyl)phenyl, 3-(2- Methylencyclopropyl)phenyl, 3-[1,1'-Bi(cyclopropyl)-1-yl]phenyl, 3-(Spiro[2.2]pentan-1- BCS241005-Ausland STR 393 yl)phenyl, 3-Chlor-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Brom-5-methyl-4,5-dihydro-1,2- oxazol-5-yl, 3,5-Dimethyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Trifluormethyl-5-methyl-4,5-dihydro- 1,2-oxazol-5-yl, 3-(5-Amino-2-chlor-4-fluorphenyl)-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3- (5-Nitro-2-chlor-4-fluorphenyl)-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-[2-Chlor-5-(3,5- 5 dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorphenyl]-5-methyl-4,5-dihydro- 1,2-oxazol-5-yl, 3-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6- dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{2-Brom-4-fluor- 5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5- dihydro-1,2-oxazol-5-yl, 3-{2-Iod-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-10 dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-chlor-4-fluorphenyl}-5-methyl-4,5- dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin- 1(2H)-yl]-2-brom-4-fluorphenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-iod-4-fluorphenyl}-5-methyl-4,5-15 dihydro-1,2-oxazol-5-yl, 2-{5-[3-Amino-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin- 1(2H)-yl]-2-chlor-4-fluorphenyl}-1,3-thiazol-5-yl, 2-{5-[3-Amino-2,6-dioxo-4-(trifluormethyl)- 3,6-dihydropyrimidin-1(2H)-yl]-2-brom-4-fluorphenyl}-1,3-thiazol-5-yl, 2-{5-[3-Amino-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-iod-4-fluorphenyl}-1,3-thiazol-5-yl, 2-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-20 yl]phenyl}-1,3-thiazol-5-yl, 2-{2-Brom-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6- dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 2-{2-Iod-4-fluor-5-[3-methyl-2,6-dioxo-4- (trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 2-[2-Chlor-5-(3,5- dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorphenyl]-1,3-thiazol-5-yl, 1,3- Thiazol-5-yl, 1,3-Thiazol-4-yl, 2-Chlor-1,3-thiazol-5-yl, 2-Chlor-1,3-thiazol-4-yl, 2-Methyl-1,3- 25 thiazol-5-yl, 2-Methyl-1,3-thiazol-4-yl, 4-Methyl-1,3-thiazol-2-yl, 5-Methyl-1,3-thiazol-2-yl, Thien-2-yl, Thien-3-yl, 5-Chlorthien-2-yl, 5-Bromthien-2-yl, 4-Chlorthien-2-yl, 4-Bromthien-2- yl, 3-Chlorthien-2-yl, 3-Bromthien-2-yl, 4,5-Dichlorthien-2-yl, 4,5-Dibromthien-2-yl, 3,4- Dichlorthien-2-yl, 3,4-Dibromthien-2-yl, 4-Brom-3-methoxythien-2-yl, 4-Brom-3-methylthien- 2-yl, 5-(1-Cyanocycloprop-1-yl)thien-2-yl, 3-Trifluormethylthien-2-yl, 4-Trifluormethylthien-2-30 yl, 5-Trifluormethylthien-2-yl, 3-Trifluormethoxythien-2-yl, 4-Trifluormethoxythien-2-yl, 3- Difluormethoxythien-2-yl, 4-Difluormethoxythien-2-yl, 3-Difluormethoxy-5-methylthien-2-yl, 4-Chlorthien-3-yl, 5-Chlorthien-3-yl, 2-Chlorthien-3-yl, 4-Bromthien-3-yl, 4-Methylthien-3-yl, 2,4-Dichlorthien-3-yl, 2,5-Dichlorthien-3-yl, 1-Methyl-1H-pyrazol-5-yl, 1-Ethyl-1H-pyrazol-5- yl, 4-Chlor-1,3-Dimethyl-1H-pyrazol-5-yl, 1,3-Dimethyl-1H-pyrazol-5-yl, 4-Chlor-1H-pyrazol-35 5-yl, 1-Methyl-1H-pyrazol-4-yl, 4-Methyl-1,2,3-thiadiazol-5-yl, 3-Methyl-1,2-oxazol-5-yl, 4- Methyl-1,2-oxazol-5-yl, 5-Methyl-1,2-oxazol-3-yl, 4-Methyl-1,3-oxazol-5-yl, 4,5-Dichlor-1,2- thiazol-3-yl, 1,2-Thiazol-3-yl, 1,2-Thiazol-5-yl, 4-Chlor-1,2-thiazol-5-yl, 3-Chlor-1,2-thiazol-5- BCS241005-Ausland STR 394 yl, 3,4-Dichlor-1,2-thiazol-5-yl, 3-Chlor-4-Cyano-1,2-thiazol-5-yl, 1,2-Benzoxazol-3-yl, 1,2- Benzothiazol-3-y1, 7-Chlor-1,2-benzothiazol-3-yl, 3-Trimethylsilyl-5-trifluormethylphenyl, 3,5- bis(Trimethylsilyl)phenyl, 3-(1,1-Dimethyleth-1-yl)-5-trifluormethyl, 3-Methylsulfonyl-5- (1,1,2,2-tetrafluoroethyl)phenyl, 3-Brom-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-Chlor-5-(1,1,2,2- 5 tetrafluoroethyl)phenyl 3-Fluor-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-Brom-5- cyclopropylsulfonylphenyl, 3-Cyclopropylsulfonyl-5-trimethylsilylphenyl, 3- Cyclopropylsulfonyl-5-trifluormethylphenyl, 3-[cyclopropyl(difluoro)methyl]-5- trifluoromethoxyphenyl, 3-[Cyclopropyl(difluor)methyl]-5-trifluoromethylphenyl, 3-Brom-5- [cyclopropyl(difluor)methyl]phenyl, 3-Chlor-5-[cyclopropyl(difluor)methyl]phenyl, 3-Fluor-5-10 [cyclopropyl(difluor)methyl]phenyl, 3-[Cyclopropyl(difluor)methyl]-5-methylsulfonylphenyl, 3- [Chlor(difluor)methyl]-5-methylsulfonylphenyl, 3,5-bis[Chlor(difluor)methyl]phenyl, 3-(1,1- Difluoreth-1-yl)-5-trifluormethylphenyl, 3-(1,1-Difluoreth-1-yl)-5-trifluormethoxyphenyl, 3- (1,1-Difluoreth-1-yl)-5-chlorphenyl, 3-(1,1-Difluoreth-1-yl)-5-bromphenyl, 3- trifluormethylsulfanylphenyl, 3-trifluormethylsulfanyl-5-chlorphenyl, 3-trifluormethylsulfanyl- 15 5-fluorphenyl, 3-trifluormethylsulfanyl-5-bromphenyl, 3-trifluormethylsulfanyl-4-chlorphenyl, 3-trifluormethylsulfanyl-4-fluorphenyl, 3-trifluormethylsulfanyl-4-bromphenyl, 3-(4- Methoxycarbonylphenyl)-5-trifluormethylphenyl, 4-Chlor-3-nitrophenyl, 3-Chlor-4-nitrophenyl, 3-(Oxetan-3-yl)phenyl, 3-(3-Fluoroxetan-3-yl)phenyl, 3-(Oxetan-3-yl)-5-trifluormethoxyphenyl, 3-(3-Fluoroxetan-3-yl)-5-trifluormethylphenyl, 4-Trifluormethylsulfanylpyridin-3-yl, 5-20 Trifluormethylsulfanylpyridin-3-yl, 6-Trifluormethylsulfanylpyridin-3-yl, 3- (Methylsulfonyloxy)phenyl, 3-(Methylsulfonyloxy)-5-chlorphenyl, 3-(Methylsulfonyloxy)-5- trifluormethylphenyl, 3-(Methylsulfonyloxy)-5-trifluormethoxyphenyl, 3- (Trifluormethylsulfonyloxy)phenyl, 3-(Trifluormethylsulfonyloxy)-5-chlorphenyl, 3- (Trifluormethylsulfonyloxy)-5-trifluormethylphenyl, 3-(Trifluormethylsulfonyloxy)-5-25 trifluormethoxyphenyl, 4-(Methylsulfonyloxy)phenyl, 3-(Methylsulfonyloxy)-4-chlorphenyl, 3- (Methylsulfonyloxy)-4-trifluormethylphenyl, 3-(Methylsulfonyloxy)-4-trifluormethoxyphenyl, 3-chlor-4-(Methylsulfonyloxy)phenyl, 3-Trifluormethyl-4-(methylsulfonyloxy)phenyl, 3- Trifluormethoxy-4-(methylsulfonyloxy)phenyl, 3-(3-Methyl-1,2,4-oxadiazol-5-yl)-5- (trifluormethoxy)phenyl, 3-Chlor-5-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl, 4-Chlor-3-(3-30 methyl-1,2,4-oxadiazol-5-yl)phenyl, 3-(5-Methyl-1,3,4-oxadiazol-2-yl)-5- (trifluormethoxy)phenyl, 3-Chlor-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl, 4-Chlor-3-(5- methyl-1,3,4-oxadiazol-2-yl)phenyl, 3-(5-Methyl-1,2,4-oxadiazol-3-yl)-5- (trifluormethoxy)phenyl, 3-Chlor-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl, 4-Chlor-3-(5- methyl-1,2,4-oxadiazol-3-yl)phenyl, 3-(2,5-Dioxoimidazolidin-4-yl)-5-(trifluormethoxy)phenyl, 35 3-Chlor-5-(2,5-dioxoimidazolidin-4-yl)phenyl, 4-Chlor-3-(2,5-dioxoimidazolidin-4-yl)phenyl, 3-(5-Oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(5-oxo-4,5- dihydro-1H-1,2,4-triazol-3-yl)phenyl, 4-Chlor-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3- BCS241005-Ausland STR 395 yl)phenyl, 3-(5-Oxo-4,5-dihydro-1H-pyrazol-3-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(5- oxo-4,5-dihydro-1H-pyrazol-3-yl)phenyl, 4-Chlor-3-(5-oxo-4,5-dihydro-1H-pyrazol-3- yl)phenyl, 3-(1,3-Thiazol-2-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(1,3-thiazol-2-yl)phenyl, 4-Chlor-3-(1,3-thiazol-2-yl)phenyl, 3-(2-Methyl-1,3-thiazol-5-yl)-5-(trifluormethoxy)phenyl, 3- 5 Chlor-5-(2-methyl-1,3-thiazol-5-yl)phenyl, 4-Chlor-3-(2-methyl-1,3-thiazol-5-yl)phenyl, 3-(1,3- Oxazol-2-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(1,3-oxazol-2-yl)phenyl, 4-Chlor-3-(1,3- oxazol-2-yl)phenyl, 3-(2-Methyl-1,3-oxazol-5-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2- methyl-1,3-oxazol-5-yl)phenyl, 4-Chlor-3-(2-methyl-1,3-oxazol-5-yl)phenyl, 3-(2-Oxoazetidin- 1-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2-oxoazetidin-1-yl)phenyl, 4-Chlor-3-(2-10 oxoazetidin-1-yl)phenyl, 3-(2-Oxopyrrolidin-1-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2- oxopyrrolidin-1-yl)phenyl, 4-Chlor-3-(2-oxopyrrolidin-1-yl)phenyl, 3-(2,4-Dioxoimidazolidin- 1-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2,4-dioxoimidazolidin-1-yl)phenyl, 4-Chlor-3-(2,4- dioxoimidazolidin-1-yl)phenyl, 3-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5- (trifluormethoxy)phenyl, 3-Chlor-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl, 4-Chlor-15 3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl, 3-(6-Methyl-2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(6-methyl-2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)phenyl, 4-Chlor-3-(6-methyl-2,4-dioxo-3,4-dihydropyrimidin- 1(2H)-yl)phenyl, 4,5-Dichlor-2-hydroxyphenyl, 3,4-Dichlor-5-hydroxyphenyl, 3,4-Dichlor-2- hydroxyphenyl, 1,3-Benzoxathiol-6-yl, 3-Methylcarbonyl-5-nitrophenyl, 4,5-Dichlor-2-20 fluorphenyl, 3,4-Dichlor-2-fluorphenyl, 3,4-Dichlor-5-fluorphenyl, 2,2-Difluor-1,3- benzodioxol-5-yl, 3-(1-Methylcycloprop-1-yl)-5-fluorphenyl, 3-(1-Methylcycloprop-1-yl)-5- chlorphenyl, 3-(1-Methylcycloprop-1-yl)-5-bromphenyl, 3-(1-Methylcycloprop-1-yl)-5- trifluormethylphenyl, 3-(1-Methylcycloprop-1-yl)-5-trifluormethoxyphenyl, 3- (Methylaminocarbonyl)-5-trifluormethoxyphenyl, 3-(Ethylaminocarbonyl)-5-25 trifluormethoxyphenyl, 3-(Prop-2-ylaminocarbonyl)-5-trifluormethoxyphenyl, 3- (Cyclopropylaminocarbonyl)-5-trifluormethoxyphenyl, 3-Aminocarbonyl-5- trifluormethoxyphenyl, 3-(Methylaminocarbonyl)-5-trifluormethylphenyl, 3- (Ethylaminocarbonyl)-5-trifluormethylphenyl, 3-(Prop-2-ylaminocarbonyl)-5- trifluormethylphenyl, 3-(Cyclopropylaminocarbonyl)-5-trifluormethylphenyl, 3-Aminocarbonyl-30 5-trifluormethylphenyl, 3-(Methylaminocarbonyl)-5-chlorphenyl, 3-(Ethylaminocarbonyl)-5- chlorphenyl, 3-(Prop-2-ylaminocarbonyl)-5-chlorphenyl, 3-(Cyclopropylaminocarbonyl)-5- chlorphenyl, 3-Aminocarbonyl-5-chlorphenyl, 3-Methyl-5-phenyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Methyl-4,5-dihydro-1,2-oxazol-5-yl steht, 35 R2 für Wasserstoff steht, BCS241005-Ausland STR 396 R3 für Methyl, Ethyl, Prop-1-yl, 1-Methylethyl, But-1-yl, 1-Methylprop-1-yl, 2-Methylprop-1-yl, 1,1-Dimethylethyl, Pent-1-yl, 1-Methylbut-1-yl, 2-Methylbut-1-yl, 3-Methylbut-1-yl, 1,1- Dimethylprop-1-yl, 1,2-Dimethylprop-1-yl, 2,2-Dimethylprop-1-yl, 1-Ethylprop-1-yl, Hex-1-yl, 1-Methylpent-1-yl, 2-Methylpent-1-yl, 3-Methylpent-1-yl, 4-Methylpent-1-yl, 1-Ethylbut-1-yl, 5 2-Ethylbut-1-yl, 1,2-Dimethylbut-1-yl, 1,3-Dimethylbut-1-yl, 2,2-Dimethylbut-1-yl, 3,3- Dimethylbut-1-yl, Cyclopropyl, Cyclobutyl, Cyclopentyl, Cyclohexyl, Methoxymethyl, Ethoxymethyl, Methoxyethyl, Ethoxyethyl, Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, Vinyl, Prop-1-en-1-yl, Prop-2-en-1-yl, But-1-en-1-yl, But-2-en-1-yl, But-3-en-1-yl, Pent-1-en-1-yl, Pent-2-en-1-yl, Pent-3-en-1-yl, Pent-4-en-1-yl, 1- 10 Methylprop-2-en-1-yl, 2-Methylprop-2-en-1-yl, 1-Methylbut-2-en-1-yl, 2-Methylbut-2-en-1-yl, 3-Methylbut-2-en-1-yl, 1-Methylbut-3-en-1-yl, 2-Methylbut-3-en-1-yl, 3-Methylbut-3-en-1-yl, 1,1-Dimethylprop-2-en-1-yl, 1,2-Dimethylprop-2-en-1-yl, , steht, R5, R6 für Wasserstoff stehen, 15 R7 für Wasserstoff, Fluor, Chlor, Brom, Iod, Methyl, Ethyl, Prop-1-yl, Prop-2-yl, Cyclopropyl, Cyclobutyl, Methoxy, Ethoxy, Trifluormethoxy, Difluormethoxy, Difluormethyl, Trifluormethyl steht, 20 R17, R18 , R19 und R20 unabhängig voneinander für Wasserstoff, Fluor, Chlor, Brom, Iod, Methyl, Ethyl, Prop-1-yl, Prop-2-yl, Cyclopropyl, Cyclobutyl, Cyclopentyl, Cyclohexyl, Methoxy, Ethoxy, Prop-1-yloxy, Prop-2-yloxy, Trifluormethoxy, Difluormethoxy, Difluormethyl, Trifluormethyl stehen und 25 Q für einen Rest der nachfolgenden Formeln Q-1 bis Q-500 steht BCS241005-Ausland STR 397 5 BCS241005-Ausland STR 398 5 BCS241005-Ausland STR 399 5 BCS241005-Ausland STR 400 5 BCS241005-Ausland STR 401 5 BCS241005-Ausland STR 402 5 BCS241005-Ausland STR 403 5 BCS241005-Ausland STR 404 5 BCS241005-Ausland STR 405 5 BCS241005-Ausland STR 406 5 BCS241005-Ausland STR 407 5 BCS241005-Ausland STR 408 5 BCS241005-Ausland STR 409 5 BCS241005-Ausland STR 410 6. Verbindungen der allgemeinen Formel (I) gemäß Anspruch 5, worin 5 M für eine der Gruppen M-1 M-2 M-3 steht, wobei die gestrichelte Linie die Verknüpfungsstelle zum restlichen Teil der Formel (I) kennzeichnet, 10 R1 für 3,4-Dichlorphenyl, 3,5-Dichlorphenyl, 3,4-bis(Trifluormethyl)phenyl, 3,5- bis(Trifluormethyl)phenyl, 3-Trifluormethylphenyl, 4-Trifluormethylphenyl, 3-Chlor-5- trifluormethoxyphenyl, 2-(2,2-Dibromcyclopropyl)phenyl, 3-(1-Cyanocycloprop-1-yl)phenyl, 3- Chlor-5-trifluormethylphenyl, 4-Chlor-3-trifluormethoxyphenyl, 3-Chlor-5-iodphenyl, 3-Fluor-15 5-iodphenyl, 3-Iod-4-chlorphenyl, 3-Brom-4-chlorphenyl, 3-Fluor-5-trifluormethoxyphenyl, 3- Brom-5-trifluormethoxyphenyl, 3-(Prop-2-yl)-5-trifluormethoxyphenyl, 3-[(E)- (Methoxyimino)methyl]-5-trifluormethoxyphenyl, 3-Methyl-5-trifluormethoxyphenyl, 3-Cyano- 5-trifluormethoxyphenyl, 3-Nitrophenyl, 3-Nitro-5-trifluormethylphenyl, 3-(4- Methoxycarbonylphenyl)-5-trifluormethylphenyl, 3-Fluor-5-trifluormethylphenyl, 3-Brom-5-20 trifluormethylphenyl, 3-Trifluormethyl-4-chlorphenyl, 3-Chlor-4-trifluormethylphenyl, 3,4- Diiodphenyl, 3,5-Diiodphenyl, 3-(Methylsulfanyl)-5-(1H-pyrazol-1-yl)phenyl, 4-Chlor-3- nitrophenyl, 3-Chlor-4-nitrophenyl, 5-Trifluormethylpyridin-3-yl, 2-Trifluormethylpyridin-4-yl, 5-Fluorpyrazin-2-yl, 6-Brompyridin-3-yl, 2,6-Difluorpyridin-4-yl, 3-Iod-5-trifluormethylphenyl, 3-Methylsulfonyl-5-trifluormethylphenyl, 3,5-bis(Trifluormethoxy)phenyl, 3-Difluormethoxy-5-25 trifluormethylphenyl, 3-Chlor-5-methylsulfonylphenyl, 3-Trifluormethoxyphenyl, 5- Trifluormethoxypyridin-3-yl, 3-Chlor-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3-Fluor-5-(pentafluor- λ⁶-sulfanyl)phenyl, 3-Brom-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3,5-bis(Methylsulfonyl)phenyl, 1,3-benzodithiol-5-yl, 2,3-dihydro-1,4-benzodithiin-6-yl, 2,6-bis(Trifluormethyl)phenyl, 3,4- Dibromphenyl, 3,5-bis(Methylsulfanyl)phenyl, 3,4-bis(Methylsulfanyl)phenyl, 2,3-Dihydro-1,4-30 benzoxathiin-7-yl, 2,3-Dihydro-1,4-benzoxathiin-6-yl, 1,3-Benzoxathiol-5-yl, 1,3-Benzoxathiol- 6-yl, 3-Chlor-5-cyclopropylphenyl, 3-Chlor-5-methoxyphenyl, 3-Brom-5-methoxyphenyl, 3- (1H-pyrazol-1-yl)phenyl, 3-Brom-5-methylsulfonylphenyl, 1,3-Benzodioxol-5-yl, 3-Chlor-5- BCS241005-Ausland STR 411 nitrophenyl, 4-Brom-3-methylsulfonylphenyl, 3-Nitro-4-methoxyphenyl, 2-Methylpyrimidin-5- yl, 3-Fluor-4-methylphenyl, 4-Methoxypyridin-2-yl, 5-Methylpyrazin-2-yl, 3,4- bis(Methylsulfonyl)phenyl, 3,3-Dioxido-1,3-benzoxathiol-6-yl, 3-Oxido-1,3-benzoxathiol-6-yl, 4,4-Dioxido-2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-Dioxido-2,3-dihydro-1,4-benzoxathiin-6-yl, 5 3,3-Dioxido-1,3-benzoxathiol-5-yl, 1,1,3,3-Tetraoxido-1,3-benzodithiol-5-yl, 3-(4-Chlor-1H- pyrazol-1-yl)phenyl, 3-(4-Brom-1H-pyrazol-1-yl)phenyl, 3-(4-Iod-1H-pyrazol-1-yl)phenyl, 6- Chlor-1,3-benzodioxol-5-yl, 3-Brom-4-methylsulfonylphenyl, 6-Chlorpyridin-3-yl, 1,1,4,4- Tetraoxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,1,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,4,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 3-Ethylsulfonyl-5-trifluormethoxyphenyl, 6-10 Fluorpyridin-2-yl, 3,5-Dibromphenyl, 4-(1-Cyanocycloprop-1-yl)phenyl, 5-Brompyridin-3-yl, 3- Brom-4,5-dichlorphenyl, 3,4,5-Trichlorphenyl, 3-(1-Cyanocycloprop-1-yl)-5-fluorphenyl, 3-(1- Cyanocycloprop-1-yl)-5-trifluormethoxyphenyl, 1,3-Benzothiazol-6-yl, 3-Chlor-5-cyanophenyl, 3-Methylsulfanyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2-Methyl-1,3-benzothiazol-5-yl, 2-Chlor-1,3- benzothiazol-5-yl, Naphth-2-yl, 3-Methylsulfonyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2-Methoxy-15 1,3-benzothiazol-5-yl, 4-Brom-3-chlorphenyl, 6-Bromnaphth-2-yl, 5-Bromnaphth-2-yl, 1,3- Benzothiazol-5-yl, 3-Methylsulfonyl-5-(1H-pyrazol-1-yl)phenyl, 2,3-Dichlorphenyl, 2,4- Dichlorphenyl, 2,5-Dichlorphenyl, 2,4-Dibromphenyl, 3,4-Difluorphenyl, 3,5-Difluorphenyl, 3,4-Dichlor-5-trifluormethoxyphenyl, 3-Iodphenyl, 4-Iodphenyl, 3-Chlor-1,2-thiazol-5-yl, 7- Chlor-1,2-benzothiazol-3-yl, 1,2-Benzoxazol-3-yl, 3,4-Dichlor-1,2-thiazol-5-yl, 4,5-Dichlor-1,2- 20 thiazol-3-yl, 3-Chlor-4-cyano-1,2-thiazol-5-yl, 1-Methyl-1H-pyrazol-5-yl, 5-Chlorthien-3-yl, 2,5-Dichlorthien-3-yl, 4-Methyl-1,2-oxazol-5-yl, 5-Methyl-1,2-oxazol-3-yl, 4-Methyl-1,3- oxazol-5-yl, 4-Methyl-1,2,3-thiadiazol-5-yl, 4-Methyl-1,3-thiazol-2-yl, 4-Chlor-1,3-Dimethyl- 1H-pyrazol-5-yl, 1,3-Thiazol-4-yl, 2-Chlor-1,3-thiazol-4-yl, 2-Chlor-1,3-thiazol-5-yl, 1,3- Thiazol-5-yl, 3-difluormethoxy-5-methylthien-2-yl, 3-Difluormethoxythien-2-yl, 4-Bromthien-25 3-yl, 3,4-Dibromthien-2-yl, 4-Brom-3-methoxythien-2-yl, 4-Brom-3-methylthien-2-yl, 5- Bromthien-2-yl, 4,5-Dichlorthien-2-yl, 5-Chlorthien-2-yl, 5-(1-cyanocycloprop-1-yl)thien-2-yl, 4,5-Dibromthien-2-yl, 3,5-Dimethyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Trifluormethyl-5-methyl- 4,5-dihydro-1,2-oxazol-5-yl, 2,3-Dibromphenyl, 2,5-Dibromphenyl, 4-Brom-3,5-Dichlorphenyl, 2,3-Difluorphenyl, 3-Fluor-4-chlorphenyl, 3-Methylcarbonyl-5-nitrophenyl, 4,5-Dichlor-2-30 fluorphenyl, 3,4-Dichlor-2-fluorphenyl, 3,4-Dichlor-5-fluorphenyl, 2,2-Difluor-1,3- benzodioxol-5-yl, 3-(1-Methylcycloprop-1-yl)-5-trifluormethoxyphenyl, 3- (Methylaminocarbonyl)-5-trifluormethoxyphenyl, 2-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4- (trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 3-[2-Chlor-5-(3,5- dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorphenyl]-5-methyl-4,5-dihydro-35 1,2-oxazol-5-yl, 2-[2-Chlor-5-(3,5-dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4- fluorphenyl]-1,3-thiazol-5-yl, 3-Methyl-5-phenyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Methyl-4,5- dihydro-1,2-oxazol-5-yl steht, BCS241005-Ausland STR 412 R2 für Wasserstoff steht, R3 für Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Cyclopropyl, Cyclobutyl, Vinyl steht, 5 R5, R6 für Wasserstoff stehen, R7 für Wasserstoff, Fluor, Chlor, Methyl, Methoxy steht, 10 R17, R18 , R19 und R20 unabhängig voneinander für Wasserstoff, Fluor, Chlor, Brom, Methyl, Methoxy, stehen und Q für einen Rest Q-1, Q-2, Q-23, Q-24, Q-26, Q-71, Q-72, Q-89, Q-91, Q-93, Q-115, Q-152, Q- 176, Q-179, Q-286, Q-287, Q-301, Q-302, Q-371, Q-441, Q-442, Q-444, Q-471, Q-472, Q-481, 15 Q-489, Q-490, Q-491, Q-499, Q-500 steht. 7. Verwendung einer oder mehrerer Verbindungen der allgemeinen Formel (I) und/oder deren Salze gemäß einem der Ansprüche 1 bis 6 als Herbizid und/oder Pflanzenwachstumsregulator, 20 vorzugsweise in Kulturen von Nutz- und/oder Zierpflanzen. 8. Verfahren zur Bekämpfung von Schadpflanzen und/oder zur Wachstumsregulierung von Pflanzen, dadurch gekennzeichnet, dass eine wirksame Menge einer oder mehrerer erfindungsgemäßer Verbindungen der allgemeinen Formel (I) und/oder deren Salze gemäß einem der Ansprüche 1 bis 6 25 auf die (Schad)Pflanzen, (Schad)Pflanzensamen, den Boden, in dem oder auf dem die (Schad)Pflanzen wachsen, oder die Anbaufläche appliziert wird. BCS241005-Abroad STR 370 Claims 1. Compounds of general formula (I) or their salts, 5 where M is for one of the groups M-1 M-2 M-310, where the dashed line marks the link to the rest of formula (I), R1for aryl or heteroaryl, 15 wherein the aryl or heteroaryl group is optionally further substituted by 1, 2 or 3 substituents bonded to ring carbon atoms and chosen independently of one another R4, and where, if necessary, two adjacent substituents R4with the ring carbon atoms to which they are bonded, they can form a saturated, partially saturated or 20 unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, or R1represents a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, 25 wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen and sulfur, and wherein the heterocyclyl residue is optionally substituted by one, two or three substituents, which are independently chosen from BCS241005-Abroad STR 371 of a group (C)1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C1-C6)-Cycloalkyl, (C1-C6)-Alkoxy, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl, 5 R2for hydrogen, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C1-C8)-Cyanoalkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C2-C8)-Alkenyl, (C2-C8)-Haloalkenyl, (C2-C8)-Alkynyl, (C2-C8)-Haloalkynyl, NR11R12, S(O)R14, SO2R14, C(O)OR13, C(O)R13or for aryl-(C1-C8)-alkyl, wherein the aryl group optionally carries 1 to 5 further substituents, which can be independently substituted for halogen, cyano, nitro, trimethylsilyl, pentafluorosulfanyl, -C(=S)NH2, OR13, NR11R12, SR14,10 S(O)R14, SO2R14, C(O)OR13, C(O)R13, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C2-C8)-Alkenyl, (C2-C8)-Haloalkenyl, (C2-C8)-Alkynyl, (C2-C8)-Haloalkynyl, (C3- C8)-Cycanocycloalkyl, (C3-C6)-Halocycloalkyl, (C1-C8)-Haloalkyl, (C1-C8)-Cyanoalkyl stands for, or for heteroaryl-(C1-C8)-alkyl, heterocyclyl-(C1-C8)-alkyl and wherein heterocyclyl carries n oxo groups, 15 R3for (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C2-C8)-Alkenyl, R13O-(C1-C8)-alkyl, (C3-C8)- Cycloalkyl-(C1-C8)-alkyl stands, R4for Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorosulfanyl, Nitro, Aryldiazo, 20 NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1-C8)-alkyl, OSO2-(C1-C8)-haloalkyl, OSO2-(C3-C8)-cycloalkyl, C(O)OR13, C(O)R13, C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C8)-alkyl, R13O-(C1-C8)-alkyl, R14S-(C1- C8)-alkyl, R13(O)C-(C1-C8)-alkyl, (C1-C8)-Alkyl, cyano-(C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2- C8)-Alkynyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C2-C8)-Haloalkynyl, (C3-C10)-Cycloalkyl,25 (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)- Haloalkoxy-(C1-C8)-haloalkyl, aryl, aryl-(C1-C8)-alkyl, heteroaryl, heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-haloalkyl, (C4-C10)-Cycloalkenyl- (C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-haloalkyl, heterocyclyl, heterocyclyl-(C1-C8)- alkyl, aryl-(C1-C8)-alkynyl, heteroaryl-(C1-C8)-alkynyl, heterocyclyl-(C1-C8)-alkynyl, Tris-[(C1-30°C8)-alkyl]silyl-(C2-C8)-alkynyl, Bis-[(C1-C8)-alkyl](aryl)silyl-(C2-C8)-alkynyl, Bis-aryl[(C1-C8)- alkyl]silyl-(C2-C8)-alkynyl, (C3-C8)-Cycloalkyl-(C2-C8)-alkynyl, aryl-(C2-C8)-alkenyl, heteroaryl-(C2-C8)-alkenyl, heterocyclyl-(C2-C8)-alkenyl, (C3-C8)-Cycloalkyl-(C2-C8)-alkenyl, cyano-(C3-C8)-cycloalkylaminosulfonylamino, Tris-[(C1-C8)-alkyl]silyl, Bis-[(C1-C8)-alkyl](aryl)silyl, bis-aryl[(C1-C8)-alkyl]silyl, wherein heterocyclyl carries n oxo groups and 35, wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and ... BCS241005-Abroad STR 372 (C)1-C8)-Alkylsulfonyl and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, R5, R6independently for hydrogen, halogen, cyano, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, 5 (C3-C8)-Cycloalkyl, (C3-C8)-Halocycloalkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkynyl, R13O-(C1-C8)- alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, -C=NOR13stand, R7for hydrogen, halogen, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C1-C8)-Alkoxy, (C1-C8)- 10 Haloalkoxy, (C1-C8)-Haloalkyl stands for, Q for hydroxy or a residue of the following formulas ... Q-1 Q-2 stands15 R8for hydrogen, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, heteroaryl, (C2-C8)-Alkynyl, (C2-C8)-Alkenyl, C(O)R13, C(O)OR13, (C1-C8)-Alkoxy-(C1-C8)-alkyl stands, R9for hydrogen or (C1-C8)-Alkyl stands, 20 R10for hydrogen, halogen, cyano, NO2, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C3-C8)-Halocycloalkyl, (C3-C8)-Halocycloalkyl-(C1-C8)- alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkynyl, Aryl, Aryl-(C1-C8)-alkyl, heteroaryl, heteroaryl-(C1- C8)-alkyl, heterocyclyl, heterocyclyl-(C1-C8)-alkyl, R11R12N-(C1-C8)-alkyl, R13O-(C1-C8)-alkyl, cyano-(C1-C8)-alkyl, (C1-C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-25 carbonyloxy-(C1-C8)-alkyl, arylcarbonyloxy-(C1-C8)-alkyl, heteroarylcarbonyloxy-(C1-C8)-alkyl, heterocyclylcarbonyloxy-(C1-C8)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- C8)-alkyl, R14(O)S-(C1-C8)-alkyl, R14O2S-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis-[(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, Tris- [(C1-C8)-Alkyl]silyl, bis-hydroxyboryl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkoxy]boryl-(C1-C8)-alkyl, 30 Tetramethyl-1,3,2-Dioxaborolan-2-yl, Tetramethyl-1,3,2-Dioxaborolan-2-yl-(C1-C8)-alkyl, Nitro-(C1-C8)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1C8)-alkyl, R11R12N(O)C- (C1-C8)-alkyl, Bis-(C1-C8)-alkoxy-(C1-C8)-alkyl, where heterocyclyl carries n oxo groups, or BCS241005-Abroad STR 373 R8and R10with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 5 R11and R12are the same or different and independent of each other for hydrogen, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkynyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkynyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4- C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1- C8)-Alkylthio-(C1-C8)-alkyl, (C1-C8)-Haloalkylthio-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-10 haloalkyl, aryl, aryl-(C1-C8)-alkyl, heteroaryl, heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C8)- Alkoxycarbonyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-amino-carbonyl-(C1-C8)-alkyl, aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, aryl-(C1-C8)-alkoxycarbonyl, heteroaryl-(C1-C8)-alkoxycarbonyl, (C2-C8)-Alkenyloxycarbonyl, (C2-C8)- 15 alkynyloxycarbonyl, heterocyclyl-(C1-C8)-alkyl, where heterocyclyl carries n oxo groups, or R11and R12with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by further heteroatoms and optionally further substituted 20 times, 3 to 10-membered monocyclic or bicyclic ring, R13for hydrogen, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkynyl, (C1-C8)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkynyl, (C3-C10)-Cycloalkyl, (C4-C10)- Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy- 25 (C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy- (C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, aryl, aryl-(C1-C8)-alkyl, aryl-(C1-C8)-alkoxy- (C1-C8)-alkyl, heteroaryl, heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-30 aminocarbonyl-(C1-C8)-alkyl, aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Bis-[(C1-C8)- alkyl]amino-(C2-C6)-alkyl, (C1-C8)-Alkyl-amino-(C2C6)-alkyl, aryl-(C1-C8)-alkylamino-(C2-C6)- alkyl, R14S-(C1-C8)-alkyl, R14(O)S-(C1-C8)-alkyl, R14O2S-(C1-C8)-alkyl, hydroxycarbonyl-(C1- C8)-alkyl, heterocyclyl, heterocyclyl-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis-[(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, (C1-35°C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkylcarbonyloxy-(C1-C8)-alkyl, arylcarbonyloxy-(C1-C8)-alkyl, heteroarylcarbonyloxy-(C1-C8)-alkyl, heterocyclylcarbonyloxy-(C1-C8)-alkyl, aryloxy-(C1-C8)-alkyl, heteroaryloxy-(C1-C8)-alkyl, ` ... BCS241005-Abroad STR 374 (C)1-C8)-Alkoxycarbonyl, wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1-C8)- Alkylsulfonyl, 5 R14for (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkynyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkynyl, (C3-C10)-Cycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)- Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, aryl, aryl- (C1-C8)-alkyl, heteroaryl, heteroaryl-(C1-C8)-alkyl, heterocyclyl-(C1-C8)-alkyl, (C3-C8)-10 Cycloalkyl-(C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, Amino, Bis-[(C1-C8)- alkyl]amino, (C1-C8)-Alkyl-amino, Aryl-(C1-C8)-amino, Aryl-(C1-C6)-alkyl-amino, aryl-[(C1- C8)-alkyl]amino, (C3-C8)-Cycloalkyl-amino, (C3-C8)-Cycloalkyl-[(C1-C8)-alkyl]amino, N-acetidinyl, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, wherein the last twelve mentioned residues are only bonded to sulfonyl groups and wherein heterocyclyl carries n oxo groups, and 15 wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-Alkylsulfonyl, R15and R16independently of each other for (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, Aryl, Heteroaryl, 20 Heterocyclyl, where Heterocyclyl carries n oxo groups, or R15and R16with the carbon atom to which they are bonded, form a fully saturated monocyclic carbocycle of 3 to 7 members, 25 R17, R18, R19and R20independently of each other for hydrogen, halogen, (C1-C8)-Alkyl, (C1-C8)-Alkoxy, (C1-C8)-Haloalkoxy, (C3-C8)-Cycloalkyl, (C1-C8)-haloalkyl, and 30n represents 0, 1, or 2. 2. Compounds of general formula (I) according to claim 1, wherein 35M represents one of the groups BCS241005-Abroad STR 375 ``` M-1 M-2 M-3stands, where the dashed line marks the point of connection to the rest of formula (I), 5 R1R stands for aryl or heteroaryl, wherein the aryl or heteroaryl group may be further substituted by 1, 2 or 3 independently chosen substituents bonded to ring carbon atoms4, and where, if necessary, two adjacent substituents R4with the 10 ring carbon atoms to which they are bonded, they can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, or R1stands for a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which carries n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen and sulfur, and wherein the heterocyclyl residue is optionally substituted by one, two or three substituents, which are independently chosen from a group (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C1-C6)-Cycloalkyl, (C1-C6)-Alkoxy, (C1-C6)- 20 Alkoxy-(C1-C6)-alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl; R2for hydrogen, (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C1-C7)-Cyanoalkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C2-C7)-Alkenyl, (C2-C7)-Haloalkenyl, (C2-C7)-Alkynyl, (C2-C7)-Haloalkynyl, 25 NR11R12, S(O)R14, SO2R14, C(O)OR13, C(O)R13or for aryl-(C1-C7)-alkyl, wherein the aryl group optionally carries 1 to 5 further substituents, which can be independently substituted for halogen, cyano, nitro, trimethylsilyl, pentafluorosulfanyl, -C(=S)NH2, OR13, NR11R12, SR14, S(O)R14, SO2R14, C(O)OR13, C(O)R13, (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C2-C7)-Alkenyl, (C2-C7)-Haloalkenyl, (C2-C7)-Alkynyl, (C2-C7)-Haloalkynyl, (C3-30°C7)-Cycanocycloalkyl, (C3-C7)-Halocycloalkyl, (C1-C7)-Haloalkyl, (C1-C7)-Cyanoalkyl stands for, or for heteroaryl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkyl and where heterocyclyl carries n oxo groups, BCS241005-Abroad STR 376 R3for (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C2-C7)-Alkenyl, R13O-(C1-C7)-alkyl, (C3-C7)- Cycloalkyl-(C1-C7)-alkyl stands, 5 R4for halogen, cyano, thiocyanate, isothiocyanate, pentafluorosulfanyl, nitro, aryldiazo, NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1-C7)-alkyl, OSO2-(C1-C7)-haloalkyl, OSO2-(C3-C7)-cycloalkyl, C(O)OR13, C(O)R13C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C7)-alkyl, R13O-(C1-C7)-alkyl, R13S-(C1- C7)-alkyl, R13(O)C-(C1-C7)-alkyl, (C1-C7)-Alkyl, cyano-(C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-10°C7)-Alkynyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C2-C7)-Haloalkynyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)- Haloalkoxy-(C1-C7)-haloalkyl, aryl, aryl-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-haloalkyl, (C4-C7)-Cycloalkenyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-haloalkyl, heterocyclyl, heterocyclyl-(C1-C7)-15 alkyl, aryl-(C1-C7)-alkynyl, heteroaryl-(C1-C7)-alkynyl, heterocyclyl-(C1-C7)-alkynyl, Tris-[(C1- C7)-alkyl]silyl-(C2-C7)-alkynyl, Bis-[(C1-C7)-alkyl](aryl)silyl-(C2-C7)-alkynyl, Bis-aryl[(C1-C7)- alkyl]silyl-(C2-C7)-alkynyl, (C3-C7)-Cycloalkyl-(C2-C7)-alkynyl, aryl-(C2-C7)-alkenyl, heteroaryl-(C2-C7)-alkenyl, heterocyclyl-(C2-C7)-alkenyl, (C3-C7)-Cycloalkyl-(C2-C7)-alkenyl, cyano-(C3-C7)-Cycloalkylaminosulfonylamino, Tris-[(C1-C7)-alkyl]silyl, Bis-[(C1-C7)- 20 alkyl](aryl)silyl, bis-aryl[(C1-C7)-alkyl]silyl and wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-Alkylsulfonyl and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, 25 R5, R6independently for hydrogen, halogen, cyano, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkynyl, R13O-(C1-C7)- alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, -C=NOR13standing, 30 R7for hydrogen, halogen, (C1-C7)-Alkyl, (C1-C7)-Alkoxy, (C1-C7)-Haloalkoxy, (C3-C7)- Cycloalkyl, (C1-C7)-Haloalkyl stands for, Q for hydroxy or a residue of the following formulas ... BCS241005-Abroad STR 377 ``` Q-1 Q-2 standsR8for hydrogen, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, heteroaryl, (C2-C7)-Alkynyl, (C2-C7)-Alkenyl, C(O)R13, C(O)OR13, (C1-C7)-Alkoxy-(C1-C7)-alkyl stands, 5 R9for hydrogen or (C1-C7)-Alkyl stands, R10for hydrogen, halogen, cyano, NO2, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C3-C7)-Halocycloalkyl, (C3-C7)-Halocycloalkyl-(C1-C7)-10 alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkynyl, Aryl, Aryl-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1- C7)-alkyl, heterocyclyl, heterocyclyl-(C1-C7)-alkyl, R11R12N-(C1-C7)-alkyl, R13O-(C1-C7)-alkyl, cyano-(C1-C7)-alkyl, (C1-C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- carbonyloxy-(C1-C7)-alkyl, arylcarbonyloxy-(C1-C7)-alkyl, heteroarylcarbonyloxy-(C1-C7)-alkyl, heterocyclylcarbonyloxy-(C1-C7)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1-15°C7)-alkyl, R14(O)S-(C1-C7)-alkyl, R14O2S-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, Tris- [(C1-C7)-Alkyl]silyl, bis-hydroxyboryl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkoxy]boryl-(C1-C7)-alkyl, tetramethyl-1,3,2-dioxaborolan-2-yl, tetramethyl-1,3,2-dioxaborolan-2-yl-(C1-C7)-alkyl, Nitro-(C1-C7)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1-C7)-alkyl, R11R12N(O)C- 20 (C1-C7)-alkyl, Bis-(C1-C7)-alkoxy-(C1-C7)-alkyl and wherein heterocyclyl carries n oxo groups, or R8and R10with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 25, 3 to 10-membered monocyclic or bicyclic ring, R11and R12are the same or different and independent of each other for hydrogen, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkynyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkynyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-30°C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1- C7)-Alkylthio-(C1-C7)-alkyl, (C1-C7)-Haloalkylthio-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)- haloalkyl, aryl, aryl-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C7)- Alkoxycarbonyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl-amino- ` ... BCS241005-Foreign STR 378 carbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxycarbonyl, heteroaryl-(C1-C7)-alkoxycarbonyl, (C2-C7)-Alkenyloxycarbonyl, (C2-C7)-alkynyloxycarbonyl, heterocyclyl-(C1-C7)-alkyl and where heterocyclyl carries n oxo groups, or 5 R11and R12with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 10 R13for hydrogen, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkynyl, (C1-C7)-Cyanoalkyl, (C1-C7)- Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkynyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)- Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-15 alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, aryl, aryl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxy-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C7)- Cycloalkenyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl-aminocarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, Bis-[(C1-C7)- alkyl]amino-(C2-C6)-alkyl, (C1-C7)-Alkyl-amino-(C2-C6)-alkyl, aryl-(C1-C7)-alkyl-amino-(C2-20°C6)-alkyl, R14S-(C1-C7)-alkyl, R14(O)S-(C1-C7)-alkyl, R14O2S-(C1-C7)-alkyl, hydroxycarbonyl- (C1-C7)-alkyl, heterocyclyl, heterocyclyl-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, (C1- C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkylcarbonyloxy-(C1-C7)-alkyl, arylcarbonyloxy-(C1-C7)-alkyl, heteroarylcarbonyloxy-(C1-C7)-alkyl, 25 Heterocyclylcarbonyloxy-(C1-C7)-alkyl, aryloxy-(C1-C7)-alkyl, heteroaryloxy-(C1-C7)-alkyl, (C1-C7)-Alkoxycarbonyl and wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1- C8)-Alkylsulfonyl, 30 R14for (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkynyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkynyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)- Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, aryl, aryl- (C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkyl, (C3-C7)-35 Cycloalkyl-(C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, Amino, Bis-[(C1-C7)- alkyl]amino, (C1-C7)-Alkyl-amino, Aryl-(C1-C7)-amino, Aryl-(C1-C6)-alkyl-amino, aryl-[(C1- C7)-alkyl]amino; (C3-C7)-Cycloalkyl-amino, (C3-C7)-Cycloalkyl-[(C1-C7)-alkyl]amino, N- ` ... BCS241005-Abroad STR 379 Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl, wherein the last twelve mentioned residues are bonded only to sulfonyl groups and wherein heterocyclyl carries n oxo groups, and wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and 5 (C1-C8)-Alkylsulfonyl, R15and R16independently of each other for (C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, Aryl, Heteroaryl, Heterocyclyl and where Heterocyclyl carries n oxo groups, or 10 R15and R16with the carbon atom to which they are bonded, they form a fully saturated monocyclic carbocycle of 3 to 7 members, R17, R18, R19and R20independently of each other for hydrogen, halogen, (C1-C7)-Alkyl, (C1-C7)-Alkoxy, (C1-C7)-Haloalkoxy, (C3-C7)-Cycloalkyl, (C1-C7)-haloalkyl, where 15 and n represent 0, 1, or 2. 20 3. Compounds of general formula (I) according to claim 1, wherein M represents one of the groups 25, where the dashed line marks the link to the rest of formula (I), R1R stands for aryl or heteroaryl, wherein the aryl or heteroaryl group may be further substituted by 1, 2, 30 or 3 independently chosen substituents bonded to ring carbon atoms4, BCS241005-Foreign STR 380 and where, if applicable, two adjacent substituents R4with the ring carbon atoms to which they are bonded, can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, 5 or R1stands for a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen and sulfur, and wherein the heterocyclyl residue is optionally substituted 10 by one, two or three substituents, which are independently chosen from a group (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C1-C6)-Cycloalkyl, (C1-C6)-Alkoxy, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl; 15 r2stands for hydrogen, R3for (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, R13O-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl stands, 20 R4for halogen, cyano, thiocyanate, isothiocyanate, pentafluorosulfanyl, nitro, aryldiazo, NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1-C6)-alkyl, OSO2-(C1-C6)-haloalkyl, OSO2-(C3-C6)-cycloalkyl, C(O)OR13, C(O)R13C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, R13S-(C1- C6)-alkyl, R13(O)C-(C1-C6)-alkyl, (C1-C6)-Alkyl, cyano-(C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-25°C6)-Alkynyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)- Haloalkoxy-(C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-haloalkyl, (C4-C6)-Cycloalkenyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-haloalkyl, heterocyclyl, heterocyclyl-(C1-C6)-30 alkyl, aryl-(C1-C6)-alkynyl, heteroaryl-(C1-C6)-alkynyl, heterocyclyl-(C1-C6)-alkynyl, Tris-[(C1- C6)-alkyl]silyl-(C2-C6)-alkynyl, Bis-[(C1-C6)-alkyl](aryl)silyl-(C2-C6)-alkynyl, Bis-aryl[(C1-C6)- alkyl]silyl-(C2-C6)-alkynyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkynyl, aryl-(C2-C6)-alkenyl, heteroaryl-(C2-C6)-alkenyl, heterocyclyl-(C2-C6)-alkenyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkenyl, cyano-(C3-C6)-Cycloalkylaminosulfonylamino, Tris-[(C1-C6)-alkyl]silyl, Bis-[(C1-C6)- 35 alkyl](aryl)silyl, bis-aryl[(C1-C6)-alkyl]silyl and wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl BCS241005-Abroad STR 381 and (C1-C8)-Alkylsulfonyl and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, R5, R6independently of each other for hydrogen, halogen, (C1-C6)-Alkyl, preferably 5 hydrogens each, R7for hydrogen, halogen, (C1-C6)-Alkyl, (C1-C7)-Alkoxy, (C1-C7)-Haloalkoxy, (C3-C6)- Cycloalkyl, (C1-C6)-Haloalkyl stands for, 10 Q for hydroxy or a residue of the following formulas ... Q-1 Q-2 standsR8for hydrogen, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, heteroaryl, (C2-C6)-Alkynyl, (C2-C6)-Alkenyl, C(O)R13, C(O)OR13, (C1-C6)-Alkoxy-(C1-C6)-alkyl stands, 15 R9for hydrogen or (C1-C6)-Alkyl stands, R10for hydrogen, halogen, cyano, NO2, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Halocycloalkyl-(C1-C6)-20 alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, Aryl, Aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1- C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R11R12N-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, cyano-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- carbonyloxy-(C1-C6)-alkyl, arylcarbonyloxy-(C1-C6)-alkyl, heteroarylcarbonyloxy-(C1-C6)-alkyl, heterocyclylcarbonyloxy-(C1-C6)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1-25°C6)-alkyl, R14(O)S-(C1-C6)-alkyl, R14O2S-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, Tris- [(C1-C6)-Alkyl]silyl, bis-hydroxyboryl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkoxy]boryl-(C1-C6)-alkyl, tetramethyl-1,3,2-dioxaborolan-2-yl, tetramethyl-1,3,2-dioxaborolan-2-yl-(C1-C6)-alkyl, Nitro-(C1-C6)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1-C6)-alkyl, R11R12N(O)C- 30 (C1-C6)-alkyl, Bis-(C1-C6)-alkoxy-(C1-C6)-alkyl and where heterocyclyl carries n oxo groups, or BCS241005-Abroad STR 382 R8and R10with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 5 R11and R12are the same or different and independent of each other for hydrogen, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4- C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1- C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-10 haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C6)- Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-amino-carbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl, heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)- 15 alkynyloxycarbonyl, heterocyclyl-(C1-C6)-alkyl and where heterocyclyl carries n oxo groups, or R11and R12with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 20, 3 to 10-membered monocyclic or bicyclic ring, R13for hydrogen, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl,25 (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, aryl, aryl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-30 aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)- alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, aryl-(C1-C6)-alkyl-amino-(C2- C6)-alkyl, R14S-(C1-C6)-alkyl, R14(O)S-(C1-C6)-alkyl, R14O2S-(C1-C6)-alkyl, hydroxycarbonyl- (C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1-35°C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, arylcarbonyloxy-(C1-C6)-alkyl, heteroarylcarbonyloxy-(C1-C6)-alkyl, heterocyclylcarbonyloxy-(C1-C6)-alkyl, aryloxy-(C1-C6)-alkyl, heteroaryloxy-(C1-C6)-alkyl, ```````````````````````) ...)`)`))`))`))`) ` [? (? (? (?-[... [...] [)-alkyl` ```]` ```]` BCS241005-Abroad STR 383 (C)1-C6)-Alkoxycarbonyl and wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1- C8)-Alkylsulfonyl, 5 R14for (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)- Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1- C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl-(C1-10°C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Amino, Bis- [(C1-C6)-alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, aryl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1-C6)- alkyl]amino; N-acetidinyl, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, wherein the last twelve mentioned residues are only bonded to sulfonyl groups and wherein heterocyclyl carries n 15 oxo groups, and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-Alkylsulfonyl, R15and R16independently of each other for (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, Aryl, Heteroaryl, 20 Heterocyclyl and where Heterocyclyl carries n oxo groups, or R15and R16with the carbon atom to which they are bonded, form a fully saturated monocyclic carbocycle of 3 to 7 members, 25 R17, R18, R19and R20independently of each other for hydrogen, halogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy, (C1-C6)-Haloalkoxy, (C3-C6)-Cycloalkyl, (C1-C6)-haloalkyl and 30 n represents 0, 1 or 2. 4. Compounds of general formula (I) according to claim 1, wherein M represents one of the groups BCS241005-Abroad STR 384 ``` M-1 M-2 M-3stands, where the dashed line marks the point of connection to the rest of formula (I), 5 R1R stands for aryl or heteroaryl, wherein the aryl or heteroaryl group may be further substituted by 1, 2 or 3 independently chosen substituents bonded to ring carbon atoms4, 10 and where, if applicable, two adjacent substituents R4with the ring carbon atoms to which they are bonded, can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, 15 or R1stands for a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen and sulfur, and wherein the heterocyclyl residue is optionally substituted by one, two or three substituents, which are independently chosen from 20 a group (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Cycloalkyl, (C1-C4)-Alkoxy, (C1-C4)- Alkoxy-(C1-C4)-alkyl, (C2-C4)-Alkenyl, (C1-C4)-Haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl; R2stands for hydrogen, 25 R3for (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, R13O-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl stands, R4for Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorosulfanyl, Nitro, Aryldiazo, 30 NR11R12, OR13, SR14, S(O)R14, SO2R14, S(O)(=N-R11)R14, S(O)(=N-R11)OR13, OSO2-Aryl, OSO2- (C1C5)-alkyl, OSO2-(C1C5)-haloalkyl, OSO2-(C3C6)-cycloalkyl, C(O)OR13, C(O)R13, C(O)NR11R12, C(S)NR11R12, -C=NOR13, R13OOC-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, R13S-(C1- BCS241005-Abroad STR 385 C6)-alkyl, R13(O)C-(C1-C6)-alkyl, (C1-C6)-Alkyl, cyano-(C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2- C6)-Alkynyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)- Haloalkoxy-(C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, 5 (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-haloalkyl, (C4-C6)-Cycloalkenyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-haloalkyl, heterocyclyl, heterocyclyl-(C1-C6)- alkyl, aryl-(C1-C6)-alkynyl, heteroaryl-(C1-C6)-alkynyl, heterocyclyl-(C1-C6)-alkynyl, Tris-[(C1- C6)-alkyl]silyl-(C2-C6)-alkynyl, Bis-[(C1-C6)-alkyl](aryl)silyl-(C2-C6)-alkynyl, Bis-aryl[(C1-C6)- alkyl]silyl-(C2-C6)-alkynyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkynyl, aryl-(C2-C6)-alkenyl, 10 Heteroaryl-(C2-C6)-alkenyl, heterocyclyl-(C2-C6)-alkenyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkenyl, cyano-(C3-C6)-Cycloalkylaminosulfonylamino, Tris-[(C1-C6)-alkyl]silyl, Bis-[(C1-C6)-alkyl](aryl)silyl, bis-aryl[(C1-C6)-alkyl]silyl and wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl 15 and (C1-C8)-Alkylsulfonyl and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, R5, R6stand for hydrogen, 20 R7for hydrogen, halogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy, (C1-C6)-Haloalkoxy, (C3-C6)- Cycloalkyl, (C1-C6)-Haloalkyl stands for, Q for hydroxy or a residue of the following formulas ... Q-1 Q-2 stands25 R8for hydrogen, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, heteroaryl, (C2-C6)-Alkynyl, (C2-C6)-Alkenyl, C(O)R13, C(O)OR13, (C1-C6)-Alkoxy-(C1-C6)-alkyl stands, R9for hydrogen or (C1-C6)-Alkyl stands, 30 R10for hydrogen, halogen, cyano, NO2, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Halocycloalkyl-(C1-C6)- alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, Aryl, Aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1- C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R11R12N-(C1-C6)-alkyl, R13O-(C1-C6)-alkyl, ` ... BCS241005-Foreign STR 386 Cyano-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- carbonyloxy-(C1-C6)-alkyl, arylcarbonyloxy-(C1-C6)-alkyl, heteroarylcarbonyloxy-(C1-C6)-alkyl, heterocyclylcarbonyloxy-(C1-C6)-alkyl, OR13, NR11R12, SR14, S(O)R14, SO2R14, R14S-(C1- C6)-alkyl, R14(O)S-(C1-C6)-alkyl, R14O2S-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, 5 Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, Tris- [(C1-C6)-Alkyl]silyl, bis-hydroxyboryl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkoxy]boryl-(C1-C6)-alkyl, tetramethyl-1,3,2-dioxaborolan-2-yl, tetramethyl-1,3,2-dioxaborolan-2-yl-(C1-C6)-alkyl, Nitro-(C1-C6)-alkyl, C(O)OR13, C(O)R13, C(O)NR11R12, R13O(O)C-(C1-C6)-alkyl, R11R12N(O)C- (C1-C6)-alkyl, Bis-(C1-C6)-alkoxy-(C1-C6)-alkyl and wherein heterocyclyl carries n oxo groups 10, or R8and R10with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 15 R11and R12are the same or different and independent of each other for hydrogen, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4- C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-20°C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR13, SO2R14, Heterocyclyl, (C1-C6)- Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-amino-carbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-25 alkoxycarbonyl, heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)-alkynyloxycarbonyl, heterocyclyl-(C1-C6)-alkyl and where heterocyclyl carries n oxo groups, or R11and R12with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, R13for hydrogen, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, 35 (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)- ``` BCS241005-Abroad STR 387 alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, aryl, aryl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)- 5 alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, aryl-(C1-C6)-alkyl-amino-(C2- C6)-alkyl, R14S-(C1C6)-alkyl, R14(O)S-(C1C6)-alkyl, R14O2S-(C1-C6)-alkyl, hydroxycarbonyl- (C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1- C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, 10 arylcarbonyloxy-(C1-C6)-alkyl, heteroarylcarbonyloxy-(C1-C6)-alkyl, heterocyclylcarbonyloxy-(C1-C6)-alkyl, aryloxy-(C1-C6)-alkyl, heteroaryloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl and wherein heterocyclyl carries n oxo groups and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1-15°C8)-Alkylsulfonyl, R14for (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkynyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkynyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)- Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-20 (C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Amino, Bis-[(C1-C6)- alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, aryl-[(C1- C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1-C6)-alkyl]amino; N-acetidinyl, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, wherein the last twelve 25 residues are only bonded to sulfonyl groups and wherein heterocyclyl carries n oxo groups, and wherein cycloalkyl can be substituted by one or more substituents selected from a group consisting of (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-Alkylsulfonyl, 30 R15and R16independently of each other for (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, Aryl, Heteroaryl, Heterocyclyl and where Heterocyclyl carries n oxo groups, or R15and R16with the carbon atom to which they are bonded, form a fully saturated monocyclic carbocycle of 3 to 7 members, 35 R17, R18, R19and R20independently of each other for hydrogen, halogen, (C1-C6)-Alkyl, (C1-C6)-Alkoxy, (C1-C8)-Haloalkoxy, (C3-C6)-Cycloalkyl, (C1-C6)-Haloalkyl BCS241005-Abroad STR 388 and n represents 0, 1 or 2. 5 5. Compounds of general formula (I) according to claim 1, wherein M represents one of the groups M-1 M-2 M-310, where the dashed line marks the link to the rest of formula (I), R1 for phenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2-trifluoromethylphenyl, 3-15 trifluoromethylphenyl, 4-trifluoromethylphenyl, 2-trifluoromethoxyphenyl, 3-trifluoromethoxyphenyl, 4-trifluoromethoxyphenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 3-fluorophenyl, 4-fluorophenyl, 2-fluorophenyl, 2-bromophenyl, 2-iodophenyl, 3-bromophenyl, 3-iodophenyl, 4-bromophenyl, 4-iodophenyl, 2-difluoromethylphenyl, 2-cyanophenyl, 3-difluoromethylphenyl, 3-cyanophenyl, 4-difluoromethylphenyl, 4-cyanophenyl, 20 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3,4-difluorophenyl, 2,4-difluorophenyl, 2,3-difluorophenyl, 3,5-difluorophenyl, 2,5-difluorophenyl, 2,6-difluorophenyl, 3,4-dichlorophenyl, 2,4-dichlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 2,5-dichlorophenyl, 2,6-dichlorophenyl, 3,4-dibromophenyl, 2,4-Dibromophenyl, 2,3-Dibromophenyl, 3,5-Dibromophenyl, 2,5-Dibromophenyl, 3,5-Diiodophenyl, 2,4-Diiodophenyl, 2,5-Diiodophenyl, 3,4-Diiodophenyl, 3-25 Fluoro-4-chlorophenyl, 2-Fluoro-4-chlorophenyl, 2-Fluoro-3-chlorophenyl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-chlorophenyl, 2-fluoro-6-chlorophenyl, 3-fluoro-5-bromophenyl, 3-fluoro-5-iodophenyl, 3-fluoro-4-bromophenyl, 3-fluoro-4-iodophenyl, 2-fluoro-4-trifluoromethylphenyl, 2-fluoro-4-methylphenyl, 2-fluoro-4-trifluoromethoxyphenyl, 2-fluoro-4-trifluoromethylsulfanylphenyl, 2-fluoro-4-cyanophenyl, 2-fluoro-4-methoxyphenyl, 2-fluoro-4-methoxycarbonylphenyl, 2-fluoro-4-30hydroxycarbonylphenyl, 2-fluoro-6-trifluoromethylphenyl, 2-fluoro-6-methylphenyl, 2-fluoro-6-trifluoromethoxyphenyl, 2-fluoro-6-trifluoromethylsulfanylphenyl, 2-fluoro-6-cyanophenyl, 2-fluoro-6-methoxyphenyl, 2-Fluoro-6-methoxycarbonylphenyl, 2-Fluoro-6-hydroxycarbonylphenyl, BCS241005-Abroad STR 389 3-fluoro-5-methoxycarbonylphenyl, 3-fluoro-5-hydroxycarbonylphenyl, 3-fluoro-5-cyanophenyl, 3-fluoro-5-methoxyphenyl, 3-chloro-5-methoxyphenyl, 3-bromo-5-methoxyphenyl, 3-iodo-5-methoxyphenyl, 3-chloro-4-fluorophenyl, 3-bromo-4-fluorophenyl, 3-iodo-4-fluorophenyl, 3-bromo-4-chlorophenyl, 3-iodo-4-chlorophenyl, 3-iodo-4-bromophenyl, 3-iodo-5-bromophenyl, 3-bromo-4-5-iodophenyl, 4-bromo-3-chlorophenyl, 3-chloro-4-iodophenyl, 3-Bromo-5-chlorophenyl, 3-chloro-5- iodophenyl, 3-chloro-5-cyanophenyl, 3-bromo-5-cyanophenyl, 3-iodo-5-cyanophenyl, 2-chloro-4-fluorophenyl, 2-chloro-3-fluorophenyl, 2-chloro-5-fluorophenyl, 3-chloro-5-cyclopropylphenyl, 3-(1-chlorocycloprop-1-yl)-5-chlorophenyl, 3-(1-Fluorocycloprop-1-yl)-5-chlorophenyl, 3-(1-Cyanocycloprop-1-yl)-5-chlorophenyl, 3-Cyclopropyl-5-fluorophenyl, 3-(1-Chlorocycloprop-1-yl)-10 5-fluorophenyl, 3-(1-Fluorocycloprop-1-yl)-5-fluorophenyl, 3-(1-Cyanocycloprop-1-yl)-5-fluorophenyl, 3-cyclopropyl-5-bromophenyl, 3-Cyclopropyl-5-iodophenyl, 3-(1-Chlorocycloprop-1-yl)-5-bromophenyl, 3-(1-Fluorocycloprop-1-yl)-5-bromophenyl, 3-(1-Cyanocycloprop-1-yl)-5-bromophenyl, 3-(1-Cyanocycloprop-1-yl)phenyl, 4-(1-Cyanocycloprop-1-yl)phenyl, 3-(1-Fluorocycloprop-1-yl)-5-iodophenyl, 3-(1-Fluorocycloprop-1-yl)-5-trifluoromethylphenyl, 3-(1-15 Fluorocycloprop-1-yl)-5-trifluoromethoxyphenyl, 3,4-Dimethylphenyl, 2,4-Dimethylphenyl, 2,3-Dimethylphenyl, 2,5-Dimethylphenyl, 2,6-Dimethylphenyl, 3-Fluoro-4-methylphenyl, 3-fluoro-5-methoxyphenyl, 3-fluoro-4-methoxyphenyl, 3-fluoro-5-methylphenyl, 3,5-dimethylphenyl, 3,5-bis(trifluoromethyl)phenyl, 2,5-bis(trifluoromethyl)phenyl, 2,4-bis(trifluoromethyl)phenyl, 2,6-bis(trifluoromethyl)phenyl, 2,3-bis(trifluoromethyl)phenyl, 3,5-bis(difluoromethyl)phenyl, 3,4-20 bis(trifluoromethyl)phenyl, 3,4-bis(difluoromethyl)phenyl, 2-trifluoromethyl-4-fluorophenyl, 3-fluoro-5-trifluoromethylphenyl, 3-chloro-5-trifluoromethylphenyl, 3-bromo-5-trifluoromethylphenyl, 3-iodo-5-trifluoromethylphenyl, 3-trifluoromethyl-4-iodophenyl, 3-Trifluoromethyl-4-bromophenyl, 3- Trifluoromethyl-4-trifluoromethoxyphenyl, 3-trifluoromethyl-4-difluoromethoxyphenyl, 3-trifluoromethyl-4-cyanophenyl, 3-trifluoromethyl-4-methylphenyl, 3-trifluoromethyl-4-25fluorophenyl, 3-bromo-4-trifluoromethylphenyl, 3-iodo-4-trifluoromethylphenyl, 3-methoxy-5-trifluoromethylphenyl, 3-Methyl-5-trifluoromethylphenyl, 3-chloro-5-methylphenyl, 3-bromo-5-methylphenyl, 3-iodo-5-methylphenyl, 3-difluoromethoxy-5-trifluoromethylphenyl, 3-difluoromethoxy-4-trifluoromethylphenyl, 3-difluoromethoxy-5-trifluoromethoxyphenyl, 3-difluoromethoxy-4-trifluoromethoxyphenyl, 3-difluoromethoxyphenyl, 3-Chloro-5-30 difluoromethoxyphenyl, 3-Chloro-4-difluoromethoxyphenyl, 3-Difluoromethoxy-4-chlorophenyl, 3-Bromo-5-difluoromethoxyphenyl, 3-Bromo-4-difluoromethoxyphenyl, 3-Difluoromethoxy-4-bromophenyl, 3-Fluoro-5-difluoromethoxyphenyl, 3-Fluoro-4-difluoromethoxyphenyl, 3-Difluoromethoxy-4-fluorophenyl, 3,5-bis(difluoromethoxy)phenyl, 3-trifluoromethoxy-5-trifluoromethylphenyl, 4-chloro-3-trifluoromethoxyphenyl, 3-cyano-5-trifluoromethylphenyl, 3-35 chloro-5-prop-2-ylphenyl, 3-chloro-5-ethylphenyl, 3-prop-2-yl-5-trifluoromethylphenyl, 3-ethyl-5-trifluoromethylphenyl, 3-Cyclopropyl-5-trifluoromethylphenyl, 3-(1-Chlorycloprop-1-yl)-5-trifluoromethylphenyl, 3-(1-Fluorycloprop-1-yl)-5-trifluoromethylphenyl, 3-(1-Cyanoycloprop-1- BCS241005-Ausland STR 390 yl)-5-trifluoromethylphenyl, 2-chloro-5-trifluoromethylphenyl, 2-chloro-4-trifluoromethylphenyl, 3-chloro-4-trifluoromethylphenyl, 2-chloro-6-trifluoromethylphenyl, 2-trifluoromethyl-4-chlorophenyl, 3-trifluoromethyl-4-chlorophenyl, 2,3,4-trifluorophenyl, 2,3,5-trifluorophenyl, 3,4,5-trifluorophenyl, 2,4,5-trifluorophenyl, 2,3,6-trifluorophenyl, 2,4,6-trifluorophenyl, 3,4,5-5-trichlorophenyl, 3-bromo-4,5-dichlorophenyl, 3-fluoro-4,5-dichlorophenyl, 4-bromo-3,5-dichlorophenyl, 3,4-dichloro-5-trifluoromethylphenyl, 3,4-Dichloro-5-trifluoromethoxyphenyl, 2-fluoro-3-methoxy-4-fluorophenyl, 2,4,6-trimethylphenyl, 3,4,5-trimethylphenyl, 2-fluoro-3-methylphenyl, 2-fluoro-6-methylphenyl, 2-chloro-4,5-difluorophenyl, 2-chloro-4-fluoro-5-nitrophenyl, 2-Fluoro-4-nitrophenyl, 2,4-Difluoro-3-chlorophenyl, 2-Chloro-3,6-difluorophenyl, 2,3-10 Dichloro-6-fluorophenyl, 2-Chloro-4-cyanophenyl, 2-Ethyl-4,6-dimethylphenyl, 2-Fluoro-6-ethoxycarbonylphenyl, 2-Fluoro-6-isopropyloxyphenyl, 2,6-Difluoro-3-methylphenyl, 2,6-Dichloro-3-methylphenyl, Pyridin-2-yl, Pyridin-3-yl, 2-Fluoropyridin-3-yl, 2-Chloropyridin-3-yl, 2,4-Difluoropyridin-3-yl, 2,4-Dichloropyridin-3-yl, 2,6-Difluoropyridin-3-yl, 2,6-Dichloropyridin-3-yl, 3,4-Difluoropyridin-2-yl, 3,4-Dichloropyridin-2-yl, 3,5-Difluoropyridin-2-yl, 3,5-Dichloropyridin-2-15yl, 5-Chloropyridin-2-yl, 6-Chloropyridin-2-yl, 5-Fluoropyridin-2-yl, 6-Fluoropyridin-2-yl, 5,6-Difluoropyridin-2-yl, 5,6-Dichloropyridin-2-yl, 4,6-Difluoropyridin-2-yl, 4,6-Dichloropyridin-2-yl, 2,5-Difluoropyridin-3-yl, 2,5-Dichloropyridin-3-yl, 4-Fluoropyridin-3-yl, 4-Chloropyridin-3-yl, 5-Chloropyridin-3-yl, 5-Bromopyridin-3-yl, 4-Trifluoromethylpyridin-3-yl, 4-Fluoropyridin-2-yl, 4-Chloropyridin-2-yl, 4-Methylpyridin-2-yl, 4-Trifluoromethylpyridin-2-yl, 4-Methoxypyridin-2-yl,20 4-Trifluoromethoxypyridin-2-yl, 5-Trifluoromethylpyridin-3-yl, 5-Trifluoromethoxypyridin-3-yl, 5-Methoxypyridin-3-yl, 6-Chloropyridin-3-yl, 6-Bromopyridin-3-yl, 6-Trifluoromethylpyridin-3-yl, 2-Trifluoromethylpyridin-3-yl, 3-Fluoro-5-trifluoromethoxyphenyl, 3-Chloro-5-trifluoromethoxyphenyl, 3-Bromo-5-trifluoromethoxyphenyl, 3-iodo-5-trifluoromethoxyphenyl, 3-methyl-5-trifluoromethoxyphenyl, 3-cyano-5-trifluoromethoxyphenyl, 3-(Prop-2-yl)-5-25 trifluoromethoxyphenyl, 3-(Prop-1-yl)-5-trifluoromethoxyphenyl, 3-(But-1-yl)-5-trifluoromethoxyphenyl, 3-(1,1-Dimethyleth-1-yl)-5-trifluoromethoxyphenyl, 3-Vinyl-5-trifluoromethoxyphenyl, 3-(Prop-1-en-2-yl)-5-trifluoromethoxyphenyl, 3-(Prop-1-en-1-yl)-5-trifluoromethoxyphenyl, 3-(1-Methylprop-1-en-1-yl)-5-trifluoromethoxyphenyl, 3-Ethyl-5-trifluoromethoxyphenyl, 3-cyclopropyl-5-trifluoromethoxyphenyl, 3-cyclobutyl-5-30 trifluoromethoxyphenyl, 3-cyclopentyl-5-trifluoromethoxyphenyl, 3-cyclopent-1-en-1-yl-5-trifluoromethoxyphenyl, 3-trimethylsilyl-5-trifluoromethoxyphenyl, 3-(1-Methylprop-1-yl)-5-trifluoromethoxyphenyl, 3-(1-Methylprop-2-yl)-5-trifluoromethoxyphenyl, 3-(1-Chlorycloprop-1-yl)-5-trifluoromethoxyphenyl, 3-(1-Fluorycloprop-1-yl)-5-trifluoromethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-5-trifluoromethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-4-35 trifluoromethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-5-trifluoromethylphenyl, 3-(1-Cyanocycloprop-1-yl)-4-trifluoromethylphenyl, 3,5-bis(trifluoromethoxy)phenyl, 3,4-bis(trifluoromethoxy)phenyl, 3-methoxymethyl-5-trifluoromethoxyphenyl, 3,5-Dichloropyridine-4- BCS241005-Ausland STR 391 yl, 3,5-Difluoropyridin-4-yl, 3,5-Dibromopyridin-4-yl, 3,5-Dimethylpyridin-4-yl, 3,5-bis(trifluoromethyl)pyridin-4-yl, 2,6-Dichloropyridin-4-yl, 2,6-Difluoropyridin-4-yl, 2,6-dibromopyridin-4-yl, 2,6-dimethylpyridin-4-yl, 2,6-bis(trifluoromethyl)pyridin-4-yl, 2-chloropyridin-4-yl, 2-trifluoromethylpyridin-4-yl, 3-chloropyridin-4-yl, 3-trifluoromethylpyridin-5 4-yl, 3-Chloro-5-(pentafluoro-λ⁶-sulfanyl)phenyl, 3-Fluoro-5-(pentafluoro-λ⁶-sulfanyl)phenyl, 3-Bromo-5-(pentafluoro-λ⁶-sulfanyl)phenyl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 2- Methoxy-1,3-benzothiazol-5-yl, 2-methyl-1,3-benzothiazol-5-yl, 2-chloro-1,3-benzothiazol-5-yl, naphth-2-yl, naphth-1-yl, 8-bromonaphth-2-yl, 7-bromonaphth-2-yl, 6-bromonaphth-2-yl, 5- Bromonaphth-2-yl, 3-chloro-5-methylsulfonylphenyl, 3-Chloro-4-(methylsulfonyl)phenyl, 3-bromo-10 5-methylsulfonylphenyl, 3-bromo-4-methylsulfonylphenyl, 3-methylsulfonyl-4-trifluoromethylphenyl, 3-(methylsulfonyl)-4-chlorophenyl, 4-bromo-3-methylsulfonylphenyl, 3-chloro-5-(ethylsulfonyl)phenyl, 3-Chloro-5-(prop-2-ylsulfonyl)phenyl, 3-Chloro-5-(cyclopropylsulfonyl)phenyl, 3-Methylsulfonyl-5-trifluoromethylphenyl, 3-Methylsulfonyl-5-trifluoromethoxyphenyl, 3-Methylsulfonyl-5-(1H-pyrazol-1-yl)phenyl, 3-Methylsulfonyl-5-(1H-15 1,2,4-triazol-1-yl)phenyl, 3-ethylsulfonyl-5-trifluoromethoxyphenyl, 3-Ethylsulfinyl-5-trifluoromethoxyphenyl, 3-Ethylsulfanyl-5-trifluoromethoxyphenyl, 3-Chloro-5-(methylsulfinyl)phenyl, 3-Chloro-5-(ethylsulfinyl)phenyl, 3-Chloro-5-(prop-2-ylsulfinyl)phenyl, 3-Chloro-5-(cyclopropylsulfinyl)phenyl, 3-(Methylsulfinyl)-5-trifluoromethylphenyl, 3-(Methylsulfinyl)-5-trifluoromethoxyphenyl, 3-(Methylsulfinyl)-5-(1H-pyrazol-1-yl)phenyl, 3-20(Methylsulfinyl)-5-(1H-1,2,4-triazol-1-yl)phenyl, 3-Chloro-5-(methylsulfanyl)phenyl, 3-chloro-5-(ethylsulfanyl)phenyl, 3-Chloro-5-(prop-2-ylsulfanyl)phenyl, 3-Chloro-5-(cyclopropylsulfanyl)phenyl, 3-(Methylsulfanyl)-5-trifluoromethylphenyl, 3-(Methylsulfanyl)-5-trifluoromethoxyphenyl, 3-(Methylsulfanyl)-5-(1H-pyrazol-1-yl)phenyl, 3-Methylsulfanyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2,3-dihydro-1,4-benzodioxin-6-yl, 1,1,4,4-tetraoxido-2,3-dihydro-25 1,4-benzodithiin-6-yl, 1,1,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,4,4-Trioxido-2,3- dihydro-1,4-benzodithiin-6-yl, 1,4-dioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 2,3-dihydro-1,4-benzodithiin-6-yl, 1,1,3,3-tetraoxido-1,3-benzodithiol-5-yl, 1,1,3-trioxido-1,3-benzodithiol-5-yl, 1,3-dioxido-1,3-benzodithiol-5-yl, 1,3-benzodithiol-5-yl, 2,3-dihydro-1,4-benzoxathiin-6-yl, 2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-dioxido-2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-dioxido-30 2,3-dihydro-1,4-benzoxathiin-6-yl, 3,3-dioxido-1,3-benzoxathiol-5-yl, 3-oxido-1,3-benzoxathiol-5-yl, 1,3-benzoxathiol-5-yl, 3,3-dioxido-1,3-benzoxathiol-6-yl, 3-oxido-1,3- benzoxathiol-6-yl, 1,3-benzoxathiol-6-yl, 3,5-bis(methylsulfonyl)phenyl, 3,4-bis(methylsulfonyl)phenyl, 3,5-bis(methylsulfanyl)phenyl, 3,4-bis(methylsulfanyl)phenyl, 3-(4-chloro-1H-pyrazol-1-yl)phenyl, 3-(4-Bromo-1H-pyrazol-1-yl)phenyl, 3-(4-Iodo-1H-pyrazol-1-35yl)phenyl, 3-(4-methyl-1H-pyrazol-1-yl)phenyl, 3-(4-trifluoromethyl-1H-pyrazol-1-yl)phenyl, 3-(1H-pyrazol-1-yl)phenyl, 3-(1H-pyrazol-1-yl)-5-chlorophenyl, 3-(1H-pyrazol-1-yl)-5-trifluoromethylphenyl, 3-(1H-pyrazol-1-yl)-5-trifluoromethoxyphenyl, 1,3-benzodioxol-5-yl, 7- BCS241005-Foreign STR 392 chloro-1,3-benzodioxol-5-yl, 6-chloro-1,3-benzodioxol-5-yl, 5-methylpyrazin-2-yl, 5-trifluoromethylpyrazin-2-yl, 5-fluoropyrazin-2-yl, 5-chloropyrazin-2-yl, 5-Bromopyrazin-2-yl, Pyrazin-2-yl, Pyridazin-4-yl, Pyridazin-3-yl, 2-Methylpyrimidin-5-yl, Pyrimidin-5-yl, 3-Nitro-5-methoxyphenyl, 3-Nitro-4-methoxyphenyl, 3-Chloro-5-nitrophenyl, 3-Chloro-4-nitrophenyl, 3-5 Nitro-4-chlorophenyl, 2-nitro-5-trifluoromethoxyphenyl, 3-Nitro-5-trifluoromethylphenyl, 3-nitro-4-trifluoromethoxyphenyl, 3-trifluoromethyl-4-nitrophenyl, 3-nitro-5-trifluoromethoxyphenyl, 3-nitrophenyl, 3-phenyl-5-trifluoromethylphenyl, 3-methoxycarbonylphenyl-5-trifluoromethylphenyl, 3,5-bis-(trifluoromethanesulfonyl)phenyl, 3- Fluoro-5-[(trifluoromethyl)sulfonyl]phenyl, 3-chloro-5-[(trifluoromethyl)sulfonyl]phenyl, 3-bromo-5-10[(trifluoromethyl)sulfonyl]phenyl, 3-[(1-cyanocycloprop-1-yl)-1-sulfonyl]-5-trifluoromethoxyphenyl, 3-(1-Carbamoylcyclopropyl)-5-trifluoromethylsulfonylphenyl, 3-(2-cyanopropyl-2-sulfonyl)-5-trifluoromethoxyphenyl, 3-(1-Cyano-1-methyleth-1-yl)-5-trifluoromethylsulfonylphenyl, 3-(1-Cyanocycloprop-1-yl)-5-(trifluoromethylsulfonyl)phenyl, 3-(1-Cyano-1-methyleth-1-yl)-5-trifluoromethylphenyl, 3-(1-Cyano-1-methyl-ethyl)-5-15 trifluoromethoxyphenyl, 3-[(Difluoromethyl)sulfonyl]-5-trifluoromethoxyphenyl, 3,5-bis-(difluoromethylsulfonyl)phenyl, 3-(1-methylsulfonylcyclopropyl)-5-trifluoromethoxyphenyl, 3-cyclopropylsulfamoyl-5-trifluoromethoxyphenyl, 3-methylsulfamoyl-5-trifluoromethoxyphenyl, 3-sulfamoyl-5-trifluoromethoxyphenyl, 3-(1-methyl-1-methylsulfonylethyl)-5- trifluoromethoxyphenyl, 3-bromo-5-[bromo(difluoro)methyl]phenyl, 3-chloro-5-20[chloro(difluoro)methyl]phenyl, 3-chloro-5-(2-chloro-1,1,2,2-tetrafluoroethoxyphenyl, 3-(1-methylsulfonylcyclopropyl)-5-trifluoromethylphenyl, 3-chloro-5-[1-(trifluoromethyl)cyclopropyl]phenyl, 3-Bromo-5-[1-(trifluoromethyl)cyclopropyl]phenyl, 3-bromo-5-(2,2-dichlorocyclopropyl)phenyl, 3-chloro-5-(2,2-dichlorocyclopropyl)phenyl, 3-fluoro-5-(2,2-dichlorocyclopropyl)phenyl, 3-cyclopropylsulfonyl-5-trifluoromethoxyphenyl, 3-25 Cyclobutylsulfonyl-5-trifluoromethoxyphenyl, 3-[(Prop-1-yl)sulfonyl]-5-trifluoromethoxyphenyl, 3-[Prop-2-ylsulfonyl]-5-trifluoromethoxyphenyl, 3-[1-methyl-1-(methylsulfonyl)ethyl]-5-trifluoromethylphenyl, 3-methylsulfonyl-5-(1,1,2,2-tetrafluorethoxy)phenyl, 3-Bromo-5-(1,1,2,2-tetrafluorethoxy)phenyl, 3,5-bis-(1,1,2,2-tetrafluorethoxy)phenyl, 3-(trifluoromethoxy)-5-vinylphenyl, 3-formyl-5-trifluoromethoxyphenyl, 3-[(Z)-(methoxyimino)methyl]-5-30 trifluoromethoxyphenyl, 3-[(E)-(methoxyimino)methyl]-5-trifluoromethoxyphenyl, 3-[(Z)- (ethoxyimino)methyl]-5-trifluoromethoxyphenyl, 3-[(E)-(ethoxyimino)methyl]-5-trifluoromethoxyphenyl, 3-[(Z)-(hydroxyimino)methyl]-5-trifluoromethoxyphenyl, 3-[(E)-(hydroxyimino)methyl]-5-trifluoromethoxyphenyl, 2-(2,2-difluorocyclopropyl)phenyl, 2-(2,2- Dibromocyclopropyl)phenyl, 2-(2-Bromo-2-Methylcyclopropyl)phenyl, 2-(2-35 Methylenecyclopropyl)phenyl, 2-[1,1'-Bi(cyclopropyl)-1-yl]phenyl, 2-(Spiro[2.2]pentan-1-yl)phenyl, 3-(2,2-Difluorocyclopropyl)phenyl, 3-(2-Bromo-2-Methylcyclopropyl)phenyl, 3-(2-methylenecyclopropyl)phenyl, 3-[1,1'-Bi(cyclopropyl)-1-yl]phenyl, 3-(Spiro[2.2]pentane-1- BCS241005-Abroad STR 393 yl)phenyl, 3-chloro-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-bromo-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3,5-dimethyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Trifluoromethyl-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-(5-amino-2-chloro-4-fluorophenyl)-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-(5-nitro-2-chloro-4-fluorophenyl)-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-[2-Chloro-5-(3.5-5 dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorophenyl]-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6- dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{2-bromo-4-fluoro- 5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5- dihydro-1,2-oxazol-5-yl, 3-{2-Iodo-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-10 dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-amino-2,6- dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-chloro-4-fluorophenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-amino-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin- 1(2H)-yl]-2-bromo-4-fluorophenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-iodo-4-fluorophenyl}-5-methyl-4,5-15 dihydro-1,2-oxazol-5-yl, 2-{5-[3-Amino-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-chloro-4-fluorophenyl}-1,3-thiazol-5-yl, 2-{5-[3-amino-2,6-dioxo-4-(trifluoromethyl)- 3,6-dihydropyrimidin-1(2H)-yl]-2-bromo-4-fluorophenyl}-1,3-thiazol-5-yl, 2-{5-[3-amino-2,6- dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-iodo-4-fluorophenyl}-1,3-thiazol-5-yl, 2-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-20 yl]phenyl}-1,3-thiazol-5-yl, 2-{2-bromo-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 2-{2-iodo-4-fluoro-5-[3-methyl-2,6-dioxo-4- (trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 2-[2-chloro-5-(3,5-dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorophenyl]-1,3-thiazol-5-yl, 1,3- Thiazol-5-yl, 1,3-thiazol-4-yl, 2-chloro-1,3-thiazol-5-yl, 2-chloro-1,3-thiazol-4-yl, 2-methyl-1,3-25thiazol-5-yl, 2-methyl-1,3-thiazol-4-yl, 4-methyl-1,3-thiazol-2-yl, 5-Methyl-1,3-thiazol-2-yl, thien-2-yl, Thien-3-yl, 5-chlorothien-2-yl, 5-bromothien-2-yl, 4-chlorothien-2-yl, 4-bromothien-2-yl, 3-chlorothien-2-yl, 3-bromothien-2-yl, 4,5-dichlorothien-2-yl, 4,5-dibromothien-2-yl, 3,4- Dichlorothien-2-yl, 3,4-dibromothien-2-yl, 4-bromo-3-methoxythien-2-yl, 4-bromo-3-methylthien-2-yl, 5-(1-cyanocycloprop-1-yl)thien-2-yl, 3-trifluoromethylthien-2-yl, 4-trifluoromethylthien-2-30yl, 5-trifluoromethylthien-2-yl, 3-Trifluoromethoxythien-2-yl, 4-Trifluoromethoxythien-2-yl, 3-Difluoromethoxythien-2-yl, 4-Difluoromethoxythien-2-yl, 3-Difluoromethoxy-5-methylthien-2-yl, 4-Chlorothien-3-yl, 5-Chlorothien-3-yl, 2-Chlorothien-3-yl, 4-Bromothien-3-yl, 4-Methylthien-3-yl, 2,4-Dichlorothien-3-yl, 2,5-Dichlorothien-3-yl, 1-Methyl-1H-pyrazol-5-yl, 1-Ethyl-1H-pyrazol-5-yl, 4-Chloro-1,3-Dimethyl-1H-pyrazol-5-yl, 1,3-Dimethyl-1H-pyrazol-5-yl, 4-Chloro-1H-pyrazol-35 5-yl, 1-Methyl-1H-pyrazol-4-yl, 4-Methyl-1,2,3-thiadiazol-5-yl, 3-Methyl-1,2-oxazol-5-yl, 4-Methyl-1,2-oxazol-5-yl, 5-Methyl-1,2-oxazol-3-yl, 4-Methyl-1,3-oxazol-5-yl, 4,5-Dichloro-1,2-thiazol-3-yl, 1,2-thiazol-3-yl, 1,2-thiazol-5-yl, 4-chloro-1,2-thiazol-5-yl, 3-chloro-1,2-thiazol-5-yl BCS241005-Foreign STR 394 yl, 3,4-dichloro-1,2-thiazol-5-yl, 3-chloro-4-cyano-1,2-thiazol-5-yl, 1,2-benzoxazol-3-yl, 1,2-benzothiazol-3-y1, 7-chloro-1,2-benzothiazol-3-yl, 3-Trimethylsilyl-5-trifluoromethylphenyl, 3,5-bis(Trimethylsilyl)phenyl, 3-(1,1-Dimethyleth-1-yl)-5-trifluoromethyl, 3-Methylsulfonyl-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-Bromo-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-Chloro-5-(1,1,2,2-5 tetrafluoroethyl)phenyl 3-fluoro-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-bromo-5-cyclopropylsulfonylphenyl, 3-cyclopropylsulfonyl-5-trimethylsilylphenyl, 3-cyclopropylsulfonyl-5-trifluoromethylphenyl, 3-[cyclopropyl(difluoro)methyl]-5-trifluoromethoxyphenyl, 3-[Cyclopropyl(difluoro)methyl]-5-trifluoromethylphenyl, 3-bromo-5-[cyclopropyl(difluoro)methyl]phenyl, 3-chloro-5-[cyclopropyl(difluoro)methyl]phenyl, 3-fluoro-5-10[cyclopropyl(difluoro)methyl]phenyl, 3-[cyclopropyl(difluoro)methyl]-5-methylsulfonylphenyl, 3- [Chloro(difluoro)methyl]-5-methylsulfonylphenyl, 3,5-bis[chloro(difluoro)methyl]phenyl, 3-(1,1- Difluoroeth-1-yl)-5-trifluoromethylphenyl, 3-(1,1-Difluoroeth-1-yl)-5-trifluoromethoxyphenyl, 3-(1,1-Difluoroeth-1-yl)-5-chlorophenyl, 3-(1,1-Difluoroeth-1-yl)-5-bromophenyl, 3-trifluoromethylsulfanylphenyl, 3-trifluoromethylsulfanyl-5-chlorophenyl, 3-trifluoromethylsulfanyl-15 5-fluorophenyl, 3-trifluoromethylsulfanyl-5-bromophenyl, 3-trifluoromethylsulfanyl-4-chlorophenyl, 3-trifluoromethylsulfanyl-4-fluorophenyl, 3-trifluoromethylsulfanyl-4-bromophenyl, 3-(4-methoxycarbonylphenyl)-5-trifluoromethylphenyl, 4-chloro-3-nitrophenyl, 3-chloro-4-nitrophenyl, 3-(oxetan-3-yl)phenyl, 3-(3-fluoroxetan-3-yl)phenyl, 3-(oxetan-3-yl)-5-trifluoromethoxyphenyl, 3-(3-fluoroxetan-3-yl)-5-trifluoromethylphenyl, 4-trifluoromethylsulfanylpyridin-3-yl, 5-20 Trifluoromethylsulfanylpyridin-3-yl, 6-Trifluoromethylsulfanylpyridin-3-yl, 3-(Methylsulfonyloxy)phenyl, 3-(Methylsulfonyloxy)-5-chlorophenyl, 3-(Methylsulfonyloxy)-5-trifluoromethylphenyl, 3-(Methylsulfonyloxy)-5-trifluoromethoxyphenyl, 3- (Trifluoromethylsulfonyloxy)phenyl, 3-(Trifluoromethylsulfonyloxy)-5-chlorophenyl, 3- (Trifluoromethylsulfonyloxy)-5-trifluoromethylphenyl, 3-(Trifluoromethylsulfonyloxy)-5-25 trifluoromethoxyphenyl, 4-(Methylsulfonyloxy)phenyl, 3-(Methylsulfonyloxy)-4-chlorophenyl, 3-(Methylsulfonyloxy)-4-trifluoromethylphenyl, 3-(Methylsulfonyloxy)-4-trifluoromethoxyphenyl, 3-chloro-4-(methylsulfonyloxy)phenyl, 3-trifluoromethyl-4-(methylsulfonyloxy)phenyl, 3-trifluoromethoxy-4-(methylsulfonyloxy)phenyl, 3-(3-methyl-1,2,4-oxadiazol-5-yl)-5-(trifluoromethoxy)phenyl, 3-Chloro-5-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl, 4-Chloro-3-(3-30 methyl-1,2,4-oxadiazol-5-yl)phenyl, 3-(5-methyl-1,3,4-oxadiazol-2-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl, 4-chloro-3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl, 3-(5-Methyl-1,2,4-oxadiazol-3-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl, 4-chloro-3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl, 3-(2,5-Dioxoimidazolidin-4-yl)-5-(trifluoromethoxy)phenyl, 35 3-Chloro-5-(2,5-dioxoimidazolidin-4-yl)phenyl, 4-Chloro-3-(2,5-dioxoimidazolidin-4-yl)phenyl, 3-(5-Oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-5-(trifluoromethoxy)phenyl, 3-Chloro-5-(5-oxo-4,5- dihydro-1H-1,2,4-triazol-3-yl)phenyl, 4-chloro-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3- BCS241005-Ausland STR 395 yl)phenyl, 3-(5-oxo-4,5-dihydro-1H-pyrazol-3-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(5-oxo-4,5-dihydro-1H-pyrazol-3-yl)phenyl, 4-Chloro-3-(5-oxo-4,5-dihydro-1H-pyrazol-3-yl)phenyl, 3-(1,3-thiazol-2-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(1,3-thiazol-2-yl)phenyl, 4-chloro-3-(1,3-thiazol-2-yl)phenyl, 3-(2-Methyl-1,3-thiazol-5-yl)-5-(trifluoromethoxy)phenyl, 3-5 Chloro-5-(2-methyl-1,3-thiazol-5-yl)phenyl, 4-chloro-3-(2-methyl-1,3-thiazol-5-yl)phenyl, 3-(1,3-oxazol-2-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(1,3-oxazol-2-yl)phenyl, 4-chloro-3-(1,3- oxazol-2-yl)phenyl, 3-(2-methyl-1,3-oxazol-5-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(2-methyl-1,3-oxazol-5-yl)phenyl, 4-chloro-3-(2-methyl-1,3-oxazol-5-yl)phenyl, 3-(2-oxoazetidin- 1-yl)-5-(trifluoromethoxy)phenyl, 3-Chloro-5-(2-oxoazetidin-1-yl)phenyl, 4-Chloro-3-(2-10 oxoazetidin-1-yl)phenyl, 3-(2-Oxopyrrolidin-1-yl)-5-(trifluoromethoxy)phenyl, 3-Chloro-5-(2-oxopyrrolidin-1-yl)phenyl, 4-Chloro-3-(2-oxopyrrolidin-1-yl)phenyl, 3-(2,4-Dioxoimidazolidin-1-yl)-5-(trifluoromethoxy)phenyl, 3-Chloro-5-(2,4-dioxoimidazolidin-1-yl)phenyl, 4-Chloro-3-(2,4-dioxoimidazolidin-1-yl)phenyl, 3-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl, 4-chloro-15 3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl, 3-(6-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5-(trifluoromethoxy)phenyl, 3-chloro-5-(6-methyl-2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)phenyl, 4-chloro-3-(6-methyl-2,4-dioxo-3,4-dihydropyrimidine- 1(2H)-yl)phenyl, 4,5-dichloro-2-hydroxyphenyl, 3,4-dichloro-5-hydroxyphenyl, 3,4-dichloro-2-hydroxyphenyl, 1,3-benzoxathiol-6-yl, 3-methylcarbonyl-5-nitrophenyl, 4,5-dichloro-2-20 fluorophenyl, 3,4-dichloro-2-fluorophenyl, 3,4-Dichloro-5-fluorophenyl, 2,2-Difluoro-1,3-benzodioxol-5-yl, 3-(1-Methylcycloprop-1-yl)-5-fluorophenyl, 3-(1-Methylcycloprop-1-yl)-5-chlorophenyl, 3-(1-Methylcycloprop-1-yl)-5-bromophenyl, 3-(1-Methylcycloprop-1-yl)-5-trifluoromethylphenyl, 3-(1-Methylcycloprop-1-yl)-5-trifluoromethoxyphenyl, 3-(Methylaminocarbonyl)-5-trifluoromethoxyphenyl, 3-(Ethylaminocarbonyl)-5-25 trifluoromethoxyphenyl, 3-(Prop-2-ylaminocarbonyl)-5-trifluoromethoxyphenyl, 3-(Cyclopropylaminocarbonyl)-5-trifluoromethoxyphenyl, 3-Aminocarbonyl-5-trifluoromethoxyphenyl, 3-(Methylaminocarbonyl)-5-trifluoromethylphenyl, 3-(Ethylaminocarbonyl)-5-trifluoromethylphenyl, 3-(Prop-2-ylaminocarbonyl)-5-trifluoromethylphenyl, 3-(Cyclopropylaminocarbonyl)-5-trifluoromethylphenyl, 3-Aminocarbonyl-30 5-trifluoromethylphenyl, 3-(Methylaminocarbonyl)-5-chlorophenyl, 3-(Ethylaminocarbonyl)-5- chlorophenyl, 3-(Prop-2-ylaminocarbonyl)-5-chlorophenyl, 3-(cyclopropylaminocarbonyl)-5-chlorophenyl, 3-aminocarbonyl-5-chlorophenyl, 3-methyl-5-phenyl-4,5-dihydro-1,2-oxazol-5-yl, 3-methyl-4,5-dihydro-1,2-oxazol-5-yl, 35 R2stands for hydrogen, BCS241005-Abroad STR 396 R3 for methyl, ethyl, prop-1-yl, 1-methylethyl, but-1-yl, 1-methylprop-1-yl, 2-methylprop-1-yl, 1,1-dimethylethyl, pent-1-yl, 1-methylbut-1-yl, 2-methylbut-1-yl, 3-methylbut-1-yl, 1,1-dimethylprop-1-yl, 1,2-Dimethylprop-1-yl, 2,2-Dimethylprop-1-yl, 1-Ethylprop-1-yl, Hex-1-yl, 1-Methylpent-1-yl, 2-Methylpent-1-yl, 3-Methylpent-1-yl, 4-Methylpent-1-yl, 1-Ethylbut-1-yl, 5 2-Ethylbut-1-yl, 1,2-Dimethylbut-1-yl, 1,3-Dimethylbut-1-yl, 2,2-Dimethylbut-1-yl, 3,3-Dimethylbut-1-yl, Cyclopropyl, Cyclobutyl, Cyclopentyl, Cyclohexyl, Methoxymethyl, Ethoxymethyl, Methoxyethyl, Ethoxyethyl, Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, Vinyl, Prop-1-en-1-yl, Prop-2-en-1-yl, But-1-en-1-yl, But-2-en-1-yl, But-3-en-1-yl, Pent-1-en-1-yl, Pent-2-en-1-yl, Pent-3-en-1-yl, Pent-4-en-1-yl, 1-10 Methylprop-2-en-1-yl, 2-Methylprop-2-en-1-yl, 1-Methylbut-2-en-1-yl, 2-Methylbut-2-en-1-yl, 3-methylbut-2-en-1-yl, 1-methylbut-3-en-1-yl, 2-methylbut-3-en-1-yl, 3-methylbut-3-en-1-yl, 1,1-dimethylprop-2-en-1-yl, 1,2-dimethylprop-2-en-1-yl, , is, R5, R6stand for hydrogen, 15 R720 R stands for hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, prop-1-yl, prop-2-yl, cyclopropyl, cyclobutyl, methoxy, ethoxy, trifluoromethoxy, difluoromethoxy, difluoromethyl, trifluoromethyl17, R18, R19and R20independently of each other stand for hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, prop-1-yl, prop-2-yl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, prop-1-yloxy, prop-2-yloxy, trifluoromethoxy, difluoromethoxy, difluoromethyl, trifluoromethyl, and 25 Q stands for a residue of the following formulas Q-1 to Q-500 BCS241005-Abroad STR 397 ``` 5 BCS241005-Abroad STR 398 ``` 5 BCS241005-Abroad STR 399 ``` 5 BCS241005-Abroad STR 400 ``` 5 BCS241005-Abroad STR 401 ``` 5 BCS241005-Abroad STR 402 ``` 5 BCS241005-Abroad STR 403 ``` 5 BCS241005-Abroad STR 404 ``` 5 BCS241005-Abroad STR 405 ``` 5 BCS241005-Abroad STR 406 ``` 5 BCS241005-Abroad STR 407 ``` 5 BCS241005-Abroad STR 408 ``` 5 BCS241005-Abroad STR 409 ``` 5 BCS241005-Abroad STR 410 6. Compounds of general formula (I) according to claim 5, wherein 5 M for one of the groups M-1 M-2 M-3stands, where the dashed line marks the link to the rest of formula (I), 10 R1 for 3,4-dichlorophenyl, 3,5-dichlorophenyl, 3,4-bis(trifluoromethyl)phenyl, 3,5-bis(trifluoromethyl)phenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 3-chloro-5-trifluoromethoxyphenyl, 2-(2,2-dibromocyclopropyl)phenyl, 3-(1-cyanocycloprop-1-yl)phenyl, 3- Chloro-5-trifluoromethylphenyl, 4-chloro-3-trifluoromethoxyphenyl, 3-chloro-5-iodophenyl, 3-fluoro-15-5-iodophenyl, 3-iodo-4-chlorophenyl, 3-bromo-4-chlorophenyl, 3-fluoro-5-trifluoromethoxyphenyl, 3-bromo-5-trifluoromethoxyphenyl, 3-(Prop-2-yl)-5-trifluoromethoxyphenyl, 3-[(E)- (Methoxyimino)methyl]-5-trifluoromethoxyphenyl, 3-methyl-5-trifluoromethoxyphenyl, 3-cyano-5-trifluoromethoxyphenyl, 3-nitrophenyl, 3-nitro-5-trifluoromethylphenyl, 3-(4-methoxycarbonylphenyl)-5-trifluoromethylphenyl, 3-fluoro-5-trifluoromethylphenyl, 3-bromo-5-20 trifluoromethylphenyl, 3-Trifluoromethyl-4-chlorophenyl, 3-Chloro-4-trifluoromethylphenyl, 3,4-Diiodophenyl, 3,5-Diiodophenyl, 3-(Methylsulfanyl)-5-(1H-pyrazol-1-yl)phenyl, 4-Chloro-3-nitrophenyl, 3-Chloro-4-nitrophenyl, 5-Trifluoromethylpyridin-3-yl, 2-Trifluoromethylpyridin-4-yl, 5-fluoropyrazin-2-yl, 6-bromopyridin-3-yl, 2,6-difluoropyridin-4-yl, 3-iodo-5-trifluoromethylphenyl, 3-methylsulfonyl-5-trifluoromethylphenyl, 3,5-bis(trifluoromethoxy)phenyl, 3-difluoromethoxy-5-25 trifluoromethylphenyl, 3-Chloro-5-methylsulfonylphenyl, 3-Trifluoromethoxyphenyl, 5-Trifluoromethoxypyridin-3-yl, 3-Chloro-5-(pentafluoro-λ⁶-sulfanyl)phenyl, 3-Fluoro-5-(pentafluoro-λ⁶-sulfanyl)phenyl, 3-Bromo-5-(pentafluoro-λ⁶-sulfanyl)phenyl, 3,5-bis(methylsulfonyl)phenyl, 1,3-benzodithiol-5-yl, 2,3-dihydro-1,4-benzodithiin-6-yl, 2,6-bis(trifluoromethyl)phenyl, 3,4-dibromophenyl, 3,5-bis(methylsulfanyl)phenyl, 3,4-bis(methylsulfanyl)phenyl, 2,3-dihydro-1,4-30 benzoxathiin-7-yl, 2,3-Dihydro-1,4-benzoxathiin-6-yl, 1,3-benzoxathiol-5-yl, 1,3-benzoxathiol-6-yl, 3-chloro-5-cyclopropylphenyl, 3-chloro-5-methoxyphenyl, 3-bromo-5-methoxyphenyl, 3-(1H-pyrazol-1-yl)phenyl, 3-Bromo-5-methylsulfonylphenyl, 1,3-benzodioxol-5-yl, 3-chloro-5- BCS241005-Foreign STR 411 nitrophenyl, 4-bromo-3-methylsulfonylphenyl, 3-nitro-4-methoxyphenyl, 2-methylpyrimidin-5-yl, 3-fluoro-4-methylphenyl, 4-methoxypyridin-2-yl, 5-methylpyrazin-2-yl, 3,4- bis(Methylsulfonyl)phenyl, 3,3-Dioxido-1,3-benzoxathiol-6-yl, 3-Oxido-1,3-benzoxathiol-6-yl, 4,4-Dioxido-2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-Dioxido-2,3-dihydro-1,4-benzoxathiin-6-yl, 5 3,3-Dioxido-1,3-benzoxathiol-5-yl, 1,1,3,3-Tetraoxido-1,3-benzodithiol-5-yl, 3-(4-chloro-1H-pyrazol-1-yl)phenyl, 3-(4-bromo-1H-pyrazol-1-yl)phenyl, 3-(4-iodo-1H-pyrazol-1-yl)phenyl, 6-chloro-1,3-benzodioxol-5-yl, 3-Bromo-4-methylsulfonylphenyl, 6-chloropyridin-3-yl, 1,1,4,4-tetraoxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,1,4-trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,4,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 3-Ethylsulfonyl-5-trifluoromethoxyphenyl, 6-10 Fluoropyridin-2-yl, 3,5-Dibromophenyl, 4-(1-Cyanocycloprop-1-yl)phenyl, 5-Bromopyridin-3-yl, 3-Bromo-4,5-dichlorophenyl, 3,4,5-Trichlorophenyl, 3-(1-Cyanocycloprop-1-yl)-5-fluorophenyl, 3-(1-Cyanocycloprop-1-yl)-5-trifluoromethoxyphenyl, 1,3-benzothiazol-6-yl, 3-chloro-5-cyanophenyl, 3-methylsulfanyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2-Methyl-1,3-benzothiazol-5-yl, 2-chloro-1,3-benzothiazol-5-yl, naphth-2-yl, 3-Methylsulfonyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2-Methoxy-15 1,3-benzothiazol-5-yl, 4-bromo-3-chlorophenyl, 6-bromonaphth-2-yl, 5-bromonaphth-2-yl, 1,3-benzothiazol-5-yl, 3-Methylsulfonyl-5-(1H-pyrazol-1-yl)phenyl, 2,3-dichlorophenyl, 2,4-dichlorophenyl, 2,5-dichlorophenyl, 2,4-dibromophenyl, 3,4-difluorophenyl, 3,5-difluorophenyl, 3,4-dichloro-5-trifluoromethoxyphenyl, 3-iodophenyl, 4-iodophenyl, 3-Chloro-1,2-thiazol-5-yl, 7-Chloro-1,2-benzothiazol-3-yl, 1,2-Benzoxazol-3-yl, 3,4-Dichloro-1,2-thiazol-5-yl, 4,5-Dichloro-1,2-20thiazol-3-yl, 3-Chloro-4-cyano-1,2-thiazol-5-yl, 1-Methyl-1H-pyrazol-5-yl, 5-Chlorothien-3-yl, 2,5-Dichlorothien-3-yl, 4-Methyl-1,2-oxazol-5-yl, 5-Methyl-1,2-oxazol-3-yl, 4-Methyl-1,3-oxazol-5-yl, 4-Methyl-1,2,3-thiadiazol-5-yl, 4-Methyl-1,3-thiazol-2-yl, 4-Chloro-1,3-Dimethyl- 1H-pyrazol-5-yl, 1,3-thiazol-4-yl, 2-chloro-1,3-thiazol-4-yl, 2-chloro-1,3-thiazol-5-yl, 1,3-thiazol-5-yl, 3-difluoromethoxy-5-methylthien-2-yl, 3-difluoromethoxythien-2-yl, 4-bromothien-25 3-yl, 3,4-Dibromothien-2-yl, 4-Bromo-3-methoxythien-2-yl, 4-Bromo-3-methylthien-2-yl, 5-Bromothien-2-yl, 4,5-Dichlorothien-2-yl, 5-Chlorothien-2-yl, 5-(1-cyanocycloprop-1-yl)thien-2-yl, 4,5-Dibromothien-2-yl, 3,5-Dimethyl-4,5-dihydro-1,2-oxazol-5-yl, 3-trifluoromethyl-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 2,3-dibromophenyl, 2,5-dibromophenyl, 4-bromo-3,5-dichlorophenyl, 2,3-difluorophenyl, 3-fluoro-4-chlorophenyl, 3-Methylcarbonyl-5-nitrophenyl, 4,5-Dichloro-2-30fluorophenyl, 3,4-Dichloro-2-fluorophenyl, 3,4-Dichloro-5-fluorophenyl, 2,2-Difluoro-1,3-benzodioxol-5-yl, 3-(1-Methylcycloprop-1-yl)-5-trifluoromethoxyphenyl, 3- (Methylaminocarbonyl)-5-trifluoromethoxyphenyl, 2-{2-Chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 3-[2-Chloro-5-(3,5- dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorophenyl]-5-methyl-4,5-dihydro-35 1,2-oxazol-5-yl, 2-[2-chloro-5-(3,5-dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4- fluorophenyl]-1,3-thiazol-5-yl, 3-methyl-5-phenyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Methyl-4,5-dihydro-1,2-oxazol-5-yl is, BCS241005-Abroad STR 412 R2stands for hydrogen, R3stands for Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Cyclopropyl, Cyclobutyl, Vinyl, 5 R5, R6stand for hydrogen, R710 R stands for hydrogen, fluorine, chlorine, methyl, methoxy17, R18, R19and R20independently of each other stand for hydrogen, fluorine, chlorine, bromine, methyl, methoxy, and Q stands for a residue Q-1, Q-2, Q-23, Q-24, Q-26, Q-71, Q-72, Q-89, Q-91, Q-93, Q-115, Q-152, Q-176, Q-179, Q-286, Q-287, Q-301, Q-302, Q-371, Q-441, Q-442, Q-444, Q-471, Q-472, Q-481, Q-489, Q-490, Q-491, Q-499, Q-500. 7. Use of one or more compounds of general formula (I) and/or their salts according to any one of claims 1 to 6 as a herbicide and/or plant growth regulator, 20 preferably in crops of useful and/or ornamental plants. 8. Method for controlling weeds and/or regulating plant growth, characterized in that an effective amount of one or more compounds of general formula (I) and/or their salts according to any one of claims 1 to 6 25 is applied to the (weed) plants, (weed) plant seeds, the soil in which or on which the (weed) plants grow, or the cultivation area.
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