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WO2025224051A1 - Matériaux de génération d'aérosol, produits consommables et systèmes de fourniture d'aérosol - Google Patents

Matériaux de génération d'aérosol, produits consommables et systèmes de fourniture d'aérosol

Info

Publication number
WO2025224051A1
WO2025224051A1 PCT/EP2025/060848 EP2025060848W WO2025224051A1 WO 2025224051 A1 WO2025224051 A1 WO 2025224051A1 EP 2025060848 W EP2025060848 W EP 2025060848W WO 2025224051 A1 WO2025224051 A1 WO 2025224051A1
Authority
WO
WIPO (PCT)
Prior art keywords
aerosol
nitrite
additive
tobacco
decreasing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2025/060848
Other languages
English (en)
Inventor
Daniel Arthur
Anthony Cunningham
Jessica Sholl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicoventures Trading Ltd
Original Assignee
Nicoventures Trading Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicoventures Trading Ltd filed Critical Nicoventures Trading Ltd
Publication of WO2025224051A1 publication Critical patent/WO2025224051A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/281—Treatment of tobacco products or tobacco substitutes by chemical substances the action of the chemical substances being delayed
    • A24B15/283—Treatment of tobacco products or tobacco substitutes by chemical substances the action of the chemical substances being delayed by encapsulation of the chemical substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/308—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances vitamins
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/42—Treatment of tobacco products or tobacco substitutes by chemical substances by organic and inorganic substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • A24D1/00—Cigars; Cigarettes
    • A24D1/20—Cigarettes specially adapted for simulated smoking devices

Definitions

  • the present invention relates to an aerosol-generating material comprising tobacco material and a selectively releasable source of a nitrite-decreasing additive.
  • the invention further relates to a consumable for use in an aerosol provision system, the consumable comprising an aerosol-generating material comprising tobacco material and a selectively releasable source of a nitrite-decreasing additive; and to aerosol provision systems comprising said consumable, as well as to kits comprising said consumable.
  • the invention also relates to the use of a selectively releasable source of a nitrite-decreasing additive.
  • Smoking articles such as cigarettes, cigars and the like burn tobacco during use to create tobacco smoke.
  • Alternatives to these types of combustible articles release an inhalable aerosol or vapour by releasing compounds from a substrate material by heating without burning. These may be referred to as non-combustible smoking articles or aerosol generating articles.
  • a heating device which releases compounds by heating, but not burning, a solid aerosolisable material.
  • This solid aerosolisable material may, in some cases, contain a tobacco material.
  • the heating volatilises at least one component of the material, typically forming an inhalable aerosol.
  • These products may be referred to as heat-not-burn devices, tobacco heating devices or tobacco heating products.
  • Various different arrangements for volatilising at least one component of the solid aerosolisable material are known.
  • an aerosolgenerating material comprising tobacco material and a selectively releasable source of a nitrite-decreasing additive.
  • the selectively releasable source of the nitrite-decreasing additive is configured to release the additive no more than about 5 days before the intended heating of the aerosol-generating material in an aerosol provision system.
  • the nitrite-decreasing additive is an antioxidant or a precursor to an antioxidant.
  • the nitrite-decreasing additive is one or more selected from the group consisting of: sorbic acid, a sorbic acid salt, ascorbic acid, and an ascorbic acid salt.
  • the nitrite-decreasing additive is sorbic acid salt or ascorbic acid salt, wherein the sorbic acid salt or ascorbic acid salt is a salt selected from the group consisting of a lithium, sodium, potassium, magnesium, calcium or ammonium salt.
  • the nitrite-decreasing additive is provided in encapsulated form. In some embodiments, the encapsulated nitrite-decreasing additive is provided in liquid form. In some embodiments, the encapsulated nitrite-decreasing additive is released in a temperature-dependent manner. In some embodiments, the encapsulated nitrite-decreasing additive is released upon being heated to a temperature within the range of from about 50°C to about 100°C.
  • the nitrite-decreasing additive is present in an amount of about 0.01 to about 5 wt% based on the weight of the tobacco material. In some embodiments, the nitrite-decreasing additive is present in an amount of about 0.05 to about 3 wt% based on the weight of the tobacco material.
  • a consumable for use in an aerosol provision system comprising an aerosolgenerating material comprising tobacco material and a selectively releasable source of a nitrite-decreasing additive.
  • the consumable of the second aspect comprises an aerosolgenerating material according to any embodiment of the first aspect.
  • the selectively releasable source of the nitrite-decreasing additive is not included in the aerosol-generating material.
  • the selectively releasable source of the nitrite-decreasing additive is not included in the aerosol-generating material
  • the consumable comprises a first segment or chamber within which the tobacco material is held and a second segment or chamber within which the nitrite-decreasing additive is held, the consumable being configured to allow the nitrite-decreasing additive to contact the tobacco material only when the source of the nitrite-decreasing additive is released by the consumer before the consumable generates an inhalable aerosol.
  • the nitrite-decreasing additive is present in an amount of from about 0.01 to about 5 wt% based on the weight of the tobacco material. In some embodiments, the nitrite-decreasing additive is present in an amount of from about 0.05 to about 3 wt% based on the weight of the tobacco material.
  • the nitrite-decreasing additive is present in an amount of at least about 0.01 wt%, at least about 0.02 wt%, at least about 0.03 wt%, at least about 0.05 wt%, at least about 0.1 wt%, at least about 0.2 wt%, at least about 0.3 wt%, at least about 0.4 wt%, at least about 0.5 wt%, at least about 0.6 wt%, at least about 0.7 wt%, at least about 0.8 wt%, at least about 0.9 wt%, at least about 1 wt%, at least about 1.1 wt%, at least about 1.2 wt%, at least about 1.3 wt%, at least about
  • 1.4 wt% at least about 1.5 wt%, at least about 1.6 wt%, at least about 1.7 wt%, at least about 1.8 wt%, at least about 1.9 wt%, at least about 2 wt%, at least about 2.1 wt%, at least about 2.2 wt%, at least about 2.3 wt%, at least about 2.4 wt%, at least about 2.6 wt%, at least about 2.7 wt%, at least about 2.8 wt%, at least about 2.9 wt%, or at least about 3 wt% based on the weight of the tobacco material.
  • the nitrite-decreasing additive is present in an amount of no more than about 5 wt%, no more than about 4.9 wt%, no more than about 4.8 wt%, no more than about 4.7 wt%, no more than about 4.6 wt%, no more than about
  • the nitrite-decreasing additive is present in a consumable in an amount of about 0.3 to about 20 mg. In some embodiments, the nitrite-decreasing additive is present in a consumable in an amount of from about 5 to about 20 mg.
  • the nitrite-decreasing additive is present in a consumable in an amount of at least about 0.3 mg, at least about 0.5 mg, at least about 1 mg, at least about 1.5 mg, at least about 2 mg, at least about 2.5 mg, at least about 3 mg, at least about 3.5 mg, at least about 4 mg, at least about 4.5 mg, at least about 5 mg, at least about 5.5 mg, at least about 6 mg, at least about 6.5 mg, at least about 7 mg, at least about 7.5 mg, at least about 8 mg, at least about 8.5 mg, at least about 9 mg, at least about 9.5 mg, at least about 10 mg.
  • the nitrite-decreasing additive is present in a consumable in an amount of no more than about 20 mg, no more than about 19 mg, no more than about 18 mg, no more than about 17 mg, no more than about 16 mg, no more than about 15 mg, no more than about 14 mg, no more than about 13 mg, no more than about 12 mg, no more than about 11 mg, no more than about 10 mg, no more than about 9 mg, or no more than about 8 mg, no more than about 20 mg, no more than about 20 mg, no more than about 20 mg, no more than about 20 mg.
  • the tobacco material is cut rag tobacco or reconstituted tobacco.
  • the consumable is rod shaped and has a mouth end and a distal end based on its intended use.
  • the consumable is rod shaped and has a mouth end and a distal end based on its intended use and the selectively releasable source of the nitrite-decreasing additive is configured to release the nitrite-decreasing additive so that it is provided exclusively or in a greater concentration at a location toward the mouth end of the rod.
  • the consumable is rod shaped and has a mouth end and a distal end based on its intended use and the selectively releasable source of the nitrite-decreasing additive is configured to release the nitrite-decreasing additive so that it is provided in a substantially consistent concentration throughout the rod.
  • the nitrite-decreasing additive is an antioxidant or a precursor to an antioxidant.
  • the nitrite-decreasing additive is one or more selected from the group consisting of: sorbic acid, a sorbic acid salt, ascorbic acid, and an ascorbic acid salt.
  • the nitrite-decreasing additive is sorbic acid salt or ascorbic acid salt, wherein the sorbic acid salt or ascorbic acid salt is a salt selected from the group consisting of a lithium, sodium, potassium, magnesium, calcium or ammonium salt.
  • the nitrite-decreasing additive is provided in encapsulated form.
  • the nitrite-decreasing additive is provided in liquid form.
  • the nitrite-decreasing additive is present in an amount of 0.01- 3 wt% based on the weight of the tobacco material. In some embodiments, the nitrite-decreasing additive is present in an amount of 0.01-1 wt% based on the weight of the tobacco material.
  • an aerosol provision system comprising a consumable according to any embodiment of the second aspect of the invention.
  • kits comprising: an aerosol-generating consumable comprising an aerosol-generating material comprising tobacco material; and a dispenser comprising a nitrite-decreasing additive, wherein the dispenser may be used to combine the nitrite-decreasing additive and the tobacco material prior to use of the consumable.
  • a selectively releasable source of a nitrite-decreasing additive to reduce the generation of tobaccospecific nitrosamines upon heating an aerosol-generating material.
  • the nitrite-decreasing additive is released and contacts at least some of the aerosol-generating material no more than 5 days before the intended heating of the aerosol-generating material in an aerosol provision system.
  • the aerosol-generating material comprises tobacco material or a tobacco extract.
  • Figure 1 is a side-on cross-sectional view of an illustrative article for use in an aerosol provision system and comprising an aerosol-generating material according to the present disclosure
  • Figure 2 is a perspective illustration of a non-combustible aerosol provision device for generating aerosol from an article according to the present disclosure.
  • an aerosolgenerating material comprising tobacco material and a selectively releasable source of a nitrite-decreasing additive.
  • TSNAs Tobacco-Specific Nitrosamines
  • TSNAs Tobacco-Specific Nitrosamines
  • Nitrites are precursors of nitrosating agents that react with amines to form TSNAs. Nitrites are present in tobacco material in very small quantities but are formed upon heating. By reducing nitrites, it is possible to reduce the nitrosation of amines to reduce TSNA formation.
  • the effect of many of the proposed nitrite-decreasing additives may be relatively short-lived, lasting for time periods that are shorter than the normal time periods between the manufacture of a tobacco industry product and its use by a consumer. For that reason, it is proposed that the nitrite-decreasing additive be added to the tobacco material after manufacture of the product. To achieve this, the nitrite-decreasing additive is provided in a selectively releasable form. This keeps the nitrite-decreasing additive separate from the tobacco material until shortly before the intended use of the tobacco industry product. The user is able to trigger release of the nitrite-decreasing additive and to thereby reduce TSNA generation during use of the tobacco industry product.
  • Nitrites are pre-cursors of nitrosating agents that react with amines to form TSNAs. Therefore, by reducing nitrites, the nitrosation of amines may be reduced to reduce the generation of TSNAs.
  • nitrite-decreasing additive denotes a substance that reduces the nitrites present in tobacco material. This may be achieved by removing nitrites and/or by reducing the formation of nitrites. Several classes of compounds have been shown to mitigate nitrosamine formation.
  • nitrite scavenger denotes a substance capable of reacting with nitrites. By reacting with nitrites, these nitrite scavenger compounds may be capable of decreasing the nitrites present in the tobacco material and thereby reduce TSNA formation.
  • nitrite scavengers Three different reaction mechanisms have been proposed for three main classes of compounds referred to herein as nitrite scavengers:
  • the nitrite scavenger may be one or more compounds which mitigate nitrosamine formation via any one of the above reaction pathways.
  • two or more nitrite scavenger compounds may be combined which mitigate nitrosamine formation via two or more of the above reaction pathways.
  • the nitrite scavenger is an antioxidant or a precursor to an antioxidant.
  • the nitrite scavenger is one or more antioxidant selected from the group consisting of: ascorbic acid, an ascorbic acid salt, Vitamin E.
  • Vitamin E includes the individual compounds that are referred to as Vitamin E, including tocopherols such as a-tocopherol and tocotrienols such as 6- tocotrienol.
  • Antioxidant salts may be used as nitrite scavengers, such as those selected from the group consisting of a lithium, sodium, potassium, magnesium, calcium or ammonium salt.
  • the nitrite scavenger is ammonia or a primary amine.
  • suitable primary amines include: primary alkyl amines such as methylamine and amino acids containing primary amines or thiol groups, such as L-cysteine, glycine, arginine, lysine and histidine, and primary aromatic amines such as aniline.
  • the nitrite scavenger is a phenol or a phenolic acid, such as chlorogenic acid or derivatives thereof.
  • Phenolic acids are usually divided into two main groups, namely benzoic acids and cinnamic acids. These compounds exist predominantly as hydroxybenzoic and hydroxycinnamic acids.
  • the nitrite scavenger is one or more selected from the group consisting of: caffeic acid, ferulic acid, vanillic acid, p-coumaric acid, syringic acid and sinapinic acids.
  • the formation of nitrites may be reduced by the addition of an additive that prevents to the reduction of nitrates to nitrites by microorganisms.
  • additives may be described as preservatives.
  • the additive preventing the formation of nitrites in tobacco material include one or more of: sorbic acid, benzoic acid, or salts thereof (e.g., lithium, sodium, potassium, magnesium, calcium or ammonium salts thereof).
  • the nitrite-decreasing additive is or includes sorbic acid, potassium sorbate and/or sodium sorbate.
  • the nitritedecreasing additive comprises a combination of one or more additive which acts as a nitrite scavenger, such as an antioxidant, and one or more additive which acts by preventing the formation of nitrites.
  • the nitrite-decreasing additive comprises a combination of ascorbic acid or a salt thereof and sorbic acid or a salt thereof.
  • the nitrite-decreasing additive is present in an amount of from about 0.01 to about 5 wt% based on the weight of the tobacco material. In some embodiments, the nitrite-decreasing additive is present in an amount of from about 0.01 to about 4 wt%, from about 0.01 to about 3 wt%, from about 0.01 to about 2 wt%, from about 0.01 to about 1.5 wt%, from about 0.01 to about 1.25 wt%, from about 0.01 to about 1 wt%, from about 0.01 to about 0.75 wt%, from about 0.1 to about 5 wt%, from about 0.1 to about 4 wt%, from about 0.1 to about 3 wt%, from about 0.1 to about 2 wt%, from about 0.1 to about 1 wt%, from about 0.5 to about 5 wt%, from about 0.5 to about 4 wt%, from about 0.5 to about 3 wt%, from about 0.5 to about
  • the nitrite-decreasing additive is provided in solution.
  • Suitable solvents include water and/or alcohols such as ethanol.
  • TSNAs are nitrosation products of endogenous pyridine alkaloids such as nicotine and nornicotine.
  • the most commonly studied TSNA are:
  • TSNAs are naturally present at low levels, or not at all, in fresh green tobacco and increase during curing, storage, fermentation, and processing of harvested tobacco leaves, in particular, during the tobacco curing process, generally due to nitrosation of nicotine and related tobacco alkaloids.
  • TSNAs may be present in the aerosol generated when a tobacco-containing aerosolgenerating material is heated, as a result of processes including thermogeneration (pyrosynthesis) of TSNAs and the transfer efficiency of TSNAs from the tobacco material to the aerosol emission (pyrorelease).
  • contacting tobacco material with the nitrite-decreasing additive reduces the generation of TSNAs upon heating the tobacco material.
  • the aerosol generated from an aerosol-generating material that has been contacted with the selectively releasable nitrite-decreasing additive has a lower TSNA content than the aerosol generated from the same aerosol-generating material that has not been contacted with the nitrite-decreasing additive.
  • contacting tobacco material with the nitrite-decreasing additive reduces the generation of one or more TSNA selected from:
  • contacting tobacco material with the nitrite-decreasing additive reduces the generation of one or both of:
  • contacting tobacco material with the nitrite-decreasing additive reduces the generation of NNN.
  • contacting tobacco material with the nitrite-decreasing additive reduces the generation of TSNAs by at least about 5 wt% compared to the TSNAs generated on heating an equivalent tobacco material that has not been contacted with the nitrite-decreasing additive.
  • contacting tobacco material with the nitrite-decreasing additive reduces the generation of TSNAs by at least about 10 wt%, at least about 15 wt%, at least about 20 wt%, at least about 25 wt%, at least about 30 wt%, at least about 35 wt%, at least about 40 wt%, at least 45 wt% or at least about 50 wt% compared to the TSNAs generated on heating an equivalent tobacco material that has not been contacted with the nitrite-decreasing additive.
  • the effect of contacting the tobacco material or aerosolgenerating material with a nitrite-decreasing additive may, in some embodiments, not be permanent and the effect of contacting the tobacco material or aerosol-generating material with the nitrite-decreasing additive may reduce over time following the initial contact.
  • ascorbic acid can react with N2O3, H2NC>2 + , and NOX, converting them to NO.
  • NO can oxidize to NO2 and subsequently convert back to nitrosating agents (i.e., N2O3 or N2O4).
  • nitrite-decreasing additive has been found to ensure that the treatment of the tobacco material or aerosol-generating material with the nitrite-decreasing additive is timed so as to be effective at reducing the generation of TSNAs when aerosol generating material is heated to generate an inhalable medium.
  • the selective release of the nitrite-decreasing additive allows the additive to contact the aerosol-generating material shortly before the aerosolgenerating material is heated to generate an aerosol, reducing the level of nitrites in the aerosol-generating material at the time the aerosol-generating material is heated.
  • the selectively releasable source of the nitrite-decreasing additive is configured to release the nitrite scavenger no more than about 5 days, no more than about 4 days, no more than about 3 days, no more than about 2 days or no more than about 1 day before the intended heating of the aerosol-generating material in an aerosol provision system.
  • the selectively releasable source of the nitrite-decreasing additive is configured to release the additive no more than about 1 hour before the intended heating of the aerosol-generating material in an aerosol provision system, no more than about 30 minutes, no more than about 20 minutes, no more than about 15 minutes, no more than about 10 minutes, no more than about 5 minutes, no more than about 4 minutes, no more than about 3 minutes, no more than about 2 minutes, no more than about 1 minute, or no more than about 30 seconds before the intended heating of the aerosol-generating material in an aerosol provision system.
  • the selectively releasable source of the nitrite-decreasing additive is configured to release the additive immediately prior to heating of the aerosol-generating material.
  • the selectively releasable source of the nitrite-decreasing additive is configured to release the additive during heating of the aerosol-generating material in an aerosol provision system.
  • the nitrite-decreasing additive may be configured to release the additive as the aerosol-generating material is heated but before the aerosolgenerating material reaches the temperature at which the aerosol is generated.
  • the nitrite-decreasing additive is provided in encapsulated form.
  • the nitrite-decreasing additive may be encapsulated in an encapsulating material.
  • the encapsulating material comprises at least one of a polysaccharide material such as an alginate, carrageenan or pectin material; a cellulosic material; a gelatin; a gum; a protein material; a polyol matrix material; an amorphous solid; a gel; a wax; a polyurethane; polymerised, hydrolysed ethylene vinyl acetate, a polyester, a polycarbonate, a polymethacrylate, a polyglycol, polyethylene, polystyrene, polypropylene, polyvinyl chloride or a mixture thereof.
  • a polysaccharide material such as an alginate, carrageenan or pectin material
  • a cellulosic material such as an alginate, carrageenan or pectin material
  • a cellulosic material such as an alginate
  • the encapsulated nitrite-decreasing additive is released in a temperature-dependent manner. In some embodiments, the encapsulated nitritedecreasing additive is released upon being heated to a temperature within the range of from about 50°C to about 100°C. This will mean that the additive is released almost as soon as the consumable is used. Alternatively, the release of the encapsulated nitrite-decreasing additive may be delayed until the tobacco is heated to a temperature at which the aerosol is generated, such as a temperature of at least 150°C, and optionally less than about 300°C, about 270°C or about 250°C.
  • Encapsulation can be used to reduce or prevent decomposition of the nitritedecreasing additive during storage. Encapsulation can be used to reduce or prevent unintended volatilisation of the nitrite-decreasing additive during storage, and/or to prevent migration of the nitrite-decreasing additive within the aerosol-generating material before use. Encapsulation can be used to ensure that the nitrite-decreasing additive treatment of the aerosol-generating material occurs shortly before or as the aerosol-generating material is heated to generate an aerosol.
  • the temperature-dependent release may be provided through use of an encapsulating material that melts, decomposes, reacts, degrades, swells or deforms to release the nitrite-decreasing additive at the release temperature.
  • heating may cause the encapsulated nitrite-decreasing additive to swell, causing rupture of the encapsulating material.
  • the encapsulated nitrite-decreasing additive is provided in liquid form.
  • the encapsulated nitrite-decreasing additive may be provided in the form of capsules that are powders, granules or beads. In some cases, these capsules may be carried on a substrate. In some cases, the encapsulated nitrite-decreasing additive may be provided in the form of a matrix or an amorphous solid which surrounds, encapsulates or embeds the additive.
  • the amorphous solid may comprise a polysaccharide matrix.
  • the amorphous solid may be provided as a thin film. This thin film may be provided in shredded or sheet form, for example.
  • the encapsulated nitritedecreasing additive may be present in a mixture of these forms, such as a combination of capsules and an encapsulating film.
  • the nitrite-decreasing additive is selectively releasable by a user-actuated release mechanism.
  • the nitrite-decreasing additive is encapsulated in a breakable capsule.
  • breakable capsule refers to a capsule, wherein a shell can be broken by means of a pressure to release the core; more specifically a shell can be ruptured under the pressure imposed by the user's fingers (or any other pressure creating means) when the user wants to release the core of the capsule.
  • the capsule comprises a core as described above, and a shell.
  • the capsule may present a crush strength from about 4.5 N to about 40 N or to about 25 N.
  • capsules may be substantially spherical and have a diameter of at least about 0.4 mm, 0.6 mm, 0.8 mm, 1.0 mm, 2.0 mm, 2.5 mm, 2.8 mm or 3.0 mm.
  • the diameter of the capsules may be less than about 10.0 mm, 8.0 mm, 7.0 mm, 6.0 mm, 5.5 mm, 5.0 mm, 4.5 mm, 4.0 mm, 3.5 mm or 3.2 mm.
  • the capsule diameter may be in the range of about 0.4 mm to about 10.0 mm, about 0.8 mm to about 6.0 mm, about 2.5 mm to about 5.5 mm or about 2.8 mm to about 3.2 mm.
  • the capsule may have a diameter of about 3.0 mm. These sizes are particularly suitable for incorporation of the capsule into a consumable.
  • the breakable capsule has a core-shell structure.
  • the total weight of a capsule may be in the range of about 1 mg to about 100 mg, suitably about 5 mg to about 60 mg, about 10 mg to about 50 mg, about 15 mg to about 40 mg, or about 15 mg to about 30 mg.
  • the core comprises at least about 25% w/w nitrite scavenger, based on the total weight of the core.
  • the barrier material is heat resistant. That is to say, in some embodiments, the barrier will not rupture, melt or otherwise fail at the temperature reached at the capsule site during heating of the article.
  • the additive is only released by positive action, such as rupture of the capsule, for example by the application of a compressive force, or puncture of the barrier material, for example using a blade or needle.
  • the breakable capsule includes a barrier material which retains the nitrite-decreasing additive, and wherein the barrier material comprises one or more of a gelling agent, a bulking agent, a colouring agent, a plasticiser, and a filler material.
  • the gelling agent may be, for example, a polysaccharide or cellulosic gelling agent, a gelatin, a gum, a gel, a wax or a mixture thereof.
  • Suitable polysaccharides include alginates, dextrans, maltodextrins, cyclodextrins and pectins.
  • Suitable alginates include, for instance, a salt of alginic acid, an esterified alginate or glyceryl alginate. Salts of alginic acid include ammonium alginate, triethanolamine alginate, and group I or II metal ion alginates like sodium, potassium, calcium and magnesium alginate.
  • Esterified alginates include propylene glycol alginate and glyceryl alginate.
  • the barrier material is sodium alginate and/ or calcium alginate.
  • Suitable cellulosic materials include methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, cellulose acetate and cellulose ethers.
  • the gelling agent may comprise one or more modified starches.
  • the gelling agent may comprise carrageenans.
  • Suitable gums include agar, gellan gum, gum Arabic, pullulan gum, mannan gum, gum ghatti, gum tragacanth, Karaya, locust bean, acacia gum, guar, quince seed and xanthan gums.
  • Suitable gels include agar, agarose, carrageenans, furoidan and furcellaran.
  • Suitable waxes include carnauba wax.
  • the gelling agent may comprise carrageenans and/or gellan gum; these gelling agents are particularly suitable for inclusion as the gelling agent as the pressure required to break the resulting capsules is particularly suitable.
  • the barrier material may comprise one or more bulking agents, such as starches, modified starches (such as oxidised starches) and sugar alcohols such as maltitol.
  • bulking agents such as starches, modified starches (such as oxidised starches) and sugar alcohols such as maltitol.
  • the barrier material may comprise a colouring agent which renders easier the location of the capsule within the tobacco industry product during manufacture.
  • the colouring agent is preferably chosen among colorants and pigments.
  • the barrier material may further comprise at least one buffer, such as a citrate or phosphate compound.
  • the barrier material may further comprise at least one plasticiser, which may be glycerol, sorbitol, maltitol, triacetin, polyethylene glycol, propylene glycol or another polyalcohol with plasticising properties, and optionally one acid of the monoacid, diacid or triacid type, especially citric acid, fumaric acid, malic acid, and the like.
  • the amount of plasticiser ranges from 1% to 30% by weight, preferably from 2% to 15% by weight, and even more preferably from 3 to 10% by weight of the total dry weight of the shell.
  • the barrier material may also comprise one or more filler materials.
  • suitable filler materials include starch derivatives such as dextrin, maltodextrin, cyclodextrin (alpha, beta or gamma), or cellulose derivatives such as hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), methyl cellulose (MC), carboxymethyl cellulose (CMC), polyvinyl alcohol, polyols or mixture thereof.
  • Dextrin is a preferred filler.
  • the amount of filler in the shell is at most 98.5%, preferably from 25 to 95% more preferably from 40 to 80% and even more preferably from 50 to 60 % by weight on the total dry weight of the shell.
  • the capsule shell may additionally comprise a hydrophobic outer layer which reduces the susceptibility of the capsule to moisture-induced degradation.
  • the hydrophobic outer layer is suitably selected from the group comprising waxes, especially carnauba wax, candelilla wax or beeswax, carbowax, shellac (in alcoholic or aqueous solution), ethyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, latex composition, polyvinyl alcohol, or a combination thereof. More preferably, the at least one moisture barrier agent is ethyl cellulose or a mixture of ethyl cellulose and shellac
  • Methods of making the capsules include co-extrusion, optionally followed by centrifugation and curing and/or drying. Further details are disclosed in WO 2007/010407 A2, the contents of which is incorporated herein by reference, in its entirety.
  • Aerosol-generating material is a material that is capable of generating aerosol, for example when heated, irradiated or energized in any other way. Aerosol-generating material may, for example, be in the form of a solid, liquid or semi-solid (such as a gel) which may or may not contain an active substance and/or flavourants.
  • the aerosol-generating material may comprise one or more active substances and/or flavours, one or more aerosol-former materials, and optionally one or more other functional material.
  • the aerosol-generating material may comprise a binder, such as a gelling agent, and an aerosol former.
  • a substance to be delivered and/or filler may also be present.
  • a solvent such as water, is also present and one or more other components of the aerosol-generating material may or may not be soluble in the solvent.
  • the aerosol-generating material may comprise or be in the form of an aerosol-generating film.
  • the aerosol-generating film may have a thickness of about 0.015 mm to about 1 mm.
  • the thickness may be in the range of about 0.05 mm, 0.1 mm or 0.15 mm to about 0.5 mm or 0.3 mm.
  • the aerosol-generating material may comprise more than one film, and the thickness described herein may refer to the aggregate thickness of those films.
  • the aerosol-generating film may be continuous.
  • the film may comprise or be a continuous sheet of material.
  • the sheet may be in the form of a wrapper, it may be gathered to form a gathered sheet, or it may be shredded to form a shredded sheet.
  • the shredded sheet may comprise one or more strands or strips of aerosolgenerating material.
  • the aerosol-generating film may be discontinuous.
  • the aerosolgenerating film may comprise one or more discrete portions or regions of aerosolgenerating material, such as dots, stripes or lines, which may be supported on a support.
  • the support may be planar or non-planar.
  • the aerosol-generating film may be formed by combining a binder, such as a gelling agent, with a solvent, such as water, an aerosol-former and one or more other components, such as one or more substances to be delivered, to form a slurry and then heating the slurry to volatilise at least some of the solvent to form the aerosolgenerating film.
  • a binder such as a gelling agent
  • a solvent such as water
  • an aerosol-former such as one or more other components, such as one or more substances to be delivered
  • the slurry may be heated to remove at least about 60 wt%, 70 wt%, 80 wt%, 85 wt% or 90 wt% of the solvent.
  • the aerosol-generating material may comprise or be an "amorphous solid".
  • the aerosol-generating materiel comprises an aerosol-generating film that is an amorphous solid.
  • the amorphous solid may be a "monolithic solid".
  • the amorphous solid may be substantially non-fibrous.
  • the amorphous solid may be a dried gel.
  • the amorphous solid is a solid material that may retain some fluid, such as liquid, within it.
  • the amorphous solid may, for example, comprise from about 50 wt%, 60 wt% or 70 wt% of amorphous solid, to about 90 wt%, 95 wt% or 100 wt% of amorphous solid.
  • the amorphous solid may be substantially free from (solid) botanical material.
  • the amorphous solid may be substantially tobacco free.
  • the aerosol-former material may comprise one or more constituents capable of forming an aerosol.
  • the aerosol-former material may comprise one or more of glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, meso-Erythritol, ethyl vanillate, ethyl laurate, a diethyl suberate, triethyl citrate, triacetin, a diacetin mixture, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate.
  • the one or more other functional materials included in the aerosol-generating material may comprise one or more of pH regulators, colouring agents, preservatives, binders, fillers, stabilizers and antioxidants.
  • the aerosol generating material comprises tobacco material.
  • tobacco material may include one or more of tobacco, tobacco derivatives, expanded tobacco, reconstituted tobacco, or tobacco-containing substitute materials.
  • the tobacco material may comprise one or more of ground tobacco, tobacco fibre, cut tobacco, tobacco leaf, tobacco lamina, extruded tobacco, tobacco stem, reconstituted tobacco and/or tobacco extract.
  • the reconstituted tobacco material may comprise tobacco fibres, and may be formed by casting, a Fourdrinier-based paper making-type approach with back addition of tobacco extract, or by extrusion.
  • the aerosol generating material may comprise any type of tobacco, such as single grades or blends, cut rag or whole leaf.
  • the tobacco material is cut rag tobacco or reconstituted tobacco.
  • the tobacco material may comprise tobacco particle 'fines' or dust, expanded tobacco, stems, expanded stems, and other processed stem materials, such as cut rolled stems.
  • the tobacco used to produce tobacco material may be any suitable tobacco, such as single grades or blends, cut rag or whole leaf, including Virginia and/or Burley and/or Oriental.
  • a consumable for use in an aerosol provision system comprising an aerosol-generating material comprising tobacco material and a selectively releasable source of a nitrite-decreasing additive.
  • a "consumable” is an article comprising or consisting of aerosolgenerating material, part or all of which is intended to be consumed during use by a user.
  • a consumable may comprise one or more other components, such as an aerosol-generating material storage area, an aerosol-generating material transfer component, an aerosol generation area, a housing, a wrapper, a mouthpiece, a filter and/or an aerosol-modifying agent.
  • a consumable may also comprise an aerosol generator, such as a heater, that emits heat to cause the aerosol-generating material to generate aerosol in use.
  • the heater may, for example, comprise combustible material, a material heatable by electrical conduction, or a susceptor.
  • the consumable of the second aspect comprises an aerosolgenerating material according to any embodiment of the first aspect.
  • the selectively releasable source of the nitrite-decreasing additive is not included in the aerosol-generating material. In some embodiments, the selectively releasable source of the nitrite-decreasing additive is not included in the aerosol-generating material, and the consumable comprises a first segment or chamber within which the tobacco material is held and a second segment or chamber within which the nitrite-decreasing additive is held, the consumable being configured to allow the nitrite-decreasing additive to contact the tobacco material only when the source of the nitrite-decreasing additive is released by the consumer before the consumable generates an inhalable aerosol.
  • the consumable is rod shaped and has a mouth end and a distal end based on its intended use.
  • Consumables for instance those in the shape of rods, are often named according to the product length: "regular” (typically in the range of 68 to 75 mm, e.g., from about 68 mm to about 72 mm), “short” or “mini” (68 mm or less), “king size” (typically in the range of 75 to 91 mm, e.g., from about 79 mm to about 88 mm), “long” or “super-king” (typically in the range of 91 to 105 mm, e.g., from about 94 mm to about 101 mm) and “ultra-long” (typically in the range from about 110 mm to about 121 mm).
  • the consumable is rod shaped and has a mouth end and a distal end based on its intended use and the selectively releasable source of the nitrite-decreasing additive is configured to release the additive so that it is provided exclusively or in a greater concentration at a location toward the mouth end of the rod.
  • the consumable is rod shaped and has a mouth end and a distal end based on its intended use and the selectively releasable source of the nitrite-decreasing additive is configured to release the additive so that it is provided in a substantially consistent concentration throughout the rod.
  • Figure 1 is a side-on cross-sectional view of a consumable or article 1 for use in an aerosol provision system.
  • the article comprises a consumable for a non-combustible aerosol provision system.
  • the article comprises an aerosol generating portion, in the present case a cylindrical aerosol-generating portion 2, and a mouthpiece 3 downstream from and connected to the aerosol-generating portion 2.
  • the aerosol-generating portion 2 comprises a rod or segment of aerosol-generating composition 20 wrapped in a rod wrapper 10.
  • the rod of aerosol-generating composition 20 comprises one or more aerosol-generating material.
  • the aerosol-generating material is cut or shredded and formed into a rod segment.
  • the aerosol-generating portion 2 also comprises a capsule 21, which is a selectively releasable source of a nitrite-decreasing additive.
  • the nitritedecreasing additive is the liquid core of a core-shell capsule 21.
  • the shell may be ruptured to release the liquid comprising the nitrite-decreasing additive.
  • the capsule 21 may be ruptured as a result of a compressive force applied to the capsule by the user. In other embodiments, the capsule 21 may be punctured or ruptured upon interaction with another part of the aerosol provision system, for example, upon insertion of the consumable into a device.
  • the article 1 also comprises a mouthpiece 3 which has a mouth end 3b and a distal end 3a that abuts the aerosol-generating portion 2.
  • the mouthpiece 3 illustrated in Figure 1 is located at the mouth end of the article 1 and comprises three elements, a mouthpiece body 14 downstream of a cooling section 13, and a hollow tubular element 15 downstream of the mouthpiece body 14.
  • one or two of these different mouthpiece elements may be omitted or duplicated, and/or the elements may be provided in a different sequence.
  • the hollow tubular element 15 may be omitted, and the mouthpiece body 14 may form the mouth end of the article.
  • the length of the mouthpiece body 14 may be increased, or a further body of material may be provided at the mouth end.
  • the mouthpiece comprises a mouthpiece body at the mouth end of the mouthpiece, optionally comprising a plug of cellulose acetate tow or paper, and optionally including capsule. Adjacent to this mouthpiece body is a first tube, optionally formed from paper, which abuts at its other end a further tubular section, optionally comprising cellulose acetate.
  • the cooling section 13, mouthpiece body 14 and hollow tubular element 15 are connected by a combining wrapping material 11.
  • tipping paper 9 is wrapped around the full length of the mouthpiece 3 and over part of the aerosol generating portion 2.
  • the tipping paper 9 has an adhesive on its inner surface (not shown) to connect the mouthpiece 3 and rod 2.
  • the tipping paper 9 extends about 5 mm over the rod of aerosol generating material 2 but it can alternatively extend from about 3 mm to about 15 mm over the rod 2, or from about 4 mm to about 6 mm, to provide a secure attachment between the mouthpiece 3 and rod 2.
  • the tipping paper may extend along the entire length of the rod of aerosol generating material.
  • the article 1 is provided with first and second parallel rows of perforations 12 through the tipping material 9, the combining wrapping material 11 and the tube of the cooling section 13, providing ventilation into the mouthpiece 3 at the cooling section 13.
  • the perforations 12 shown are formed as laser perforations, at positions about 18 mm and about 19 mm respectively from the downstream, mouth-end 3b of the mouthpiece 3.
  • the ventilation can be provided into the mouthpiece 3 at other locations.
  • Aerosol provision system A third aspect of the invention provides, an aerosol provision system comprising a consumable according to any embodiment of the second aspect of the invention.
  • Combustible aerosol provision systems include cigarettes, cigarillos, cigars, and tobacco for pipes or for roll-your-own or for make-your-own cigarettes (whether based on tobacco, tobacco derivatives, expanded tobacco, reconstituted tobacco, tobacco substitutes or other smokable material).
  • Non-combustible aerosol provision systems that release compounds from an aerosolgenerating material without combusting the aerosol-generating material, such as electronic cigarettes, tobacco heating products, and hybrid systems to generate aerosol using a combination of aerosol-generating materials.
  • the delivery system is a non-combustible aerosol provision system, such as a powered non-combustible aerosol provision system.
  • a "non-combustible" aerosol provision system is one where a constituent aerosol-generating material of the aerosol provision system (or component thereof) is not combusted or burned in order to facilitate delivery of at least one substance to a user.
  • the non-combustible aerosol provision system is an electronic cigarette, also known as a vaping device or electronic nicotine delivery system (END), although it is noted that the presence of nicotine in the aerosol-generating material is not a requirement.
  • END electronic nicotine delivery system
  • the non-combustible aerosol provision system is an aerosolgenerating material heating system, also known as a heat-not-burn system.
  • An example of such a system is a tobacco heating system.
  • the non-combustible aerosol provision system is a hybrid system to generate aerosol using a combination of aerosol-generating materials, one or a plurality of which may be heated.
  • Each of the aerosol-generating materials may be, for example, in the form of a solid, liquid or gel and may or may not contain nicotine.
  • the hybrid system comprises a liquid or gel aerosolgenerating material and a solid aerosol-generating material.
  • the non-combustible aerosol provision system may comprise a noncombustible aerosol provision device and an article for use with or as the noncombustible aerosol provision device, which is also referred to as a consumable for use with the non-combustible aerosol provision device.
  • the disclosure relates to consumables comprising aerosolgenerating material and configured to be used with non-combustible aerosol provision devices. These consumables are sometimes referred to as articles throughout the disclosure.
  • the non-combustible aerosol provision system such as a non-combustible aerosol provision device thereof, may comprise a power source and a controller.
  • the power source may, for example, be an electric power source or an exothermic power source.
  • the exothermic power source comprises a carbon substrate which may be energised so as to distribute power in the form of heat to an aerosol-generating material or to a heat transfer material in proximity to the exothermic power source.
  • the non-combustible aerosol provision system may comprise an area for receiving the consumable, an aerosol generator, an aerosol generation area, a housing, a mouthpiece, a filter and/or an aerosol-modifying agent.
  • the consumable for use with the non-combustible aerosol provision device may comprise aerosol-generating material, an aerosol-generating material storage area, an aerosol-generating material transfer component, an aerosol generator, an aerosol generation area, a housing, a wrapper, a filter, a mouthpiece, and/or an aerosol-modifying agent.
  • Figure 2 shows an example of a non-combustible aerosol provision device 100 for generating aerosol from an aerosol-generating composition of an article or consumable 110, as described herein.
  • the article 110 may be the article 1 shown in Figure 1.
  • the device 100 may be used to heat a replaceable article 110 comprising the aerosol-generating composition as described herein, for instance an article as described elsewhere herein, to generate an aerosol or other inhalable medium which is inhaled by a user of the device 100.
  • the device 100 and replaceable article 110 together form a system.
  • the device 100 comprises a housing 102 (in the form of an outer cover) which surrounds and houses various components of the device 100.
  • the device 100 has an opening 104 in one end, through which the article 110 may be inserted for heating by a heating assembly. In use, the article 110 may be fully or partially inserted into the heating assembly where it may be heated by one or more components of the heater assembly.
  • the article 110 is illustrated having a rod-shape, like the articles 1 illustrated in Figure 1.
  • the device 100 of this example comprises a first end member 106 which comprises a lid 108 which is moveable relative to the first end member 106 to close the opening 104 when no article 110 is in place.
  • the lid 108 is shown in an open configuration, however the lid 108 may move into a closed configuration. For example, a user may cause the lid 108 to slide in the direction of arrow "B".
  • the device 100 may also include a user-operable control element 112, such as a button or switch, which operates the device 100 when pressed.
  • a user may turn on the device 100 by operating the switch 112.
  • This switch may also actuate the means for opening the container inserted into the device, in readiness for its use.
  • the device 100 may also comprise an electrical component, such as a socket/ port 114, which can receive a cable to charge a battery of the device 100.
  • a socket/ port 114 which can receive a cable to charge a battery of the device 100.
  • the socket 114 may be a charging port, such as a USB charging port.
  • a fourth aspect of the invention provides a kit comprising: an aerosol-generating consumable comprising an aerosol-generating material comprising tobacco material; and a dispenser comprising a nitrite-decreasing additive, wherein the dispenser may be used to combine the nitrite-decreasing additive and the tobacco material prior to use of the consumable.
  • a fifth aspect of the invention provides the use of a selectively releasable source of a nitrite-decreasing additive to reduce the generation of tobacco-specific nitrosamines upon heating an aerosol-generating material.
  • the aerosol-generating material comprises tobacco material.
  • the nitrite-decreasing additive reduces the generation of one or more TSNA selected from :
  • the nitrite-decreasing additive reduces the generation of one or more TSNA selected from :
  • the nitrite-decreasing additive reduces the generation of NNN.
  • the nitrite-decreasing additive reduces the generation of TSNAs by at least about 5 wt% compared to the TSNAs generated on heating an equivalent tobacco material that was not treated with the nitrite-decreasing additive.
  • the nitrite-decreasing additive reduces the generation of TSNAs by at least about 10 wt%, by at least about 15 wt%, by at least about 20 wt%, by at least about 25 wt%, by at least about 30 wt%, by at least about 35 wt%, by at least about 40 wt%, by at least about 45 wt% or by at least about 50 wt% compared to the TSNAs generated on heating an equivalent tobacco material that was not treated with the nitrite-decreasing additive.
  • nitrite-decreasing additive and solvents (other than water) used for injections were all purchased from Sigma-Aldrich and used without purification. Their CAS numbers are listed below:
  • Nitrite was tested for using Automated Spectroscopy. Initially the ground and homogenised tobacco was extracted with ultrapure water using a heated ultrasonic bath. The samples were left to cool to room temperature before being further diluted with ultrapure water, followed by being vortexed and syringe filtered. A portion of the filtrate was then reacted with sulphanilamide and N-(l-naphthyl)ethylenediamide dihydrochloride, which created a colour reaction, the sample was then analysed using a spectrophotometer at 540 nm.
  • smoking machines are used to ensure consistent sample generation to compare results. This is achieved by setting these machines to take specific volume puffs over a set time, known as smoking regimes, that are outlined in ISO standard 20778:2018.
  • This particular study used the Health Canada Intense modified (HCIm) machine puffing regime (puff volume 55ml, puff duration 2 seconds, puff interval of 30 seconds and ventilation holes of the consumable are not blocked) (see T. J. J. Adamson, Food and Chemical Toxicology, 2018, 113, 337-344).
  • HCIm Health Canada Intense modified
  • THP consumables were injected using a 50 pl needle syringe, and, for each nitrite-decreasing additive, 60 consumables were each injected with a total volume of 50 pl.
  • absolute ethanol >99.8%
  • the plunger was removed and cleaned with absolute ethanol, and the external surface of the needle was also cleaned with absolute ethanol.
  • a small segment of filter section from a THP consumable was inserted onto the needle, this ensured the needle remained in the tobacco section of the consumable to prevent the needle entering the cooling section.
  • the needles were inserted through the centre tobacco section of the consumable. The injection was performed to distribute the additive as evenly as possible throughout the tobacco portion of the consumables.
  • control samples were also produced, each sample contained 60 consumables.
  • the controls had either no solvent injected or only solvent (i.e., no nitrite-decreasing additive), to rule out the solvent being a factor behind any TSNA changes.
  • the weight of the consumables was measured before and after every injection, so that the mass difference could be calculated.
  • the mean amounts of the NNN, NNK, NAB and NAT content in the THP emissions from those samples including a water-soluble nitrite-decreasing additive were as follows:
  • any nitrite-scavenging effect of the ascorbic acid on the tobacco material may have been short-lived, with the nitrites being replenished over time.
  • Both ascorbic acid and ascorbic acid with ferulic acid increased the NNK content compared to the water control. Although an increase was seen in NNN for ascorbic acid with ferulic acid, this was not the case for just ascorbic acid.
  • the NNN content in the vitamin E sample increased in comparison to the ethanol control.
  • sorbic acid was the most effective in decreasing NNK and ascorbic acid was the most effective at decreasing NNN, NAB, and NAT content.
  • Samples were prepared using THP consumables following the same methodology as Example 1, except where noted.
  • a 50 pl syringe (cleaned as in Example 1) was used to inject a total volume of 50 pl into each consumable.
  • the injection was performed to distribute 25 pl of the additive composition into the area extending up to 6 mm from the end of the tobacco rod abutting the mouth end cooling section of the consumable.
  • the remaining 25 pl of the additive composition was injected to be distributed as evenly as possible throughout the remaining tobacco portion of the consumables.
  • the mean amounts of the NNN, NNK, NAB and NAT content in the THP emissions from those samples including water-soluble nitrite-decreasing additives were as follows: The NNN values for ascorbic acid and sodium ascorbate were reduced by 47.1% and 44%, respectively, compared to the water control. The NNK values for ascorbic acid and sodium ascorbate were reduced by 34.1% and 19.8%, respectively, compared to the water control. The NAB values for ascorbic acid and sodium ascorbate were reduced by 51.6% and 44%, respectively, compared to the water control. The NAT values for ascorbic acid and sodium ascorbate were reduced by 49.2% and 42.9%, respectively, compared to the water control.
  • NNN, NNK and NAT values for sorbic acid were reduced by 22.1%, 32.3% and 2.3%, respectively, compared to the no solvent control. No difference was seen in the NAB value compared to the no solvent control. However, the ethanol control performed better that the sorbic acid, suggesting that further refinement of the treatment with the additive may be required to improve the effect.
  • nitrite-decreasing additives Two factors may be at play here. Firstly, some of the nitrite-decreasing additives are relatively unstable and may lose efficacy over time. Secondly, and probably more importantly, the decrease in the nitrites in the tobacco material as a result of treatment with the additives is short-lived because more nitrites are being produced and replace those that have been removed by the treatment with the additives. Additionally, as noted above, it is possible that the amount of the nitrite-decreasing additive added may have been too low and/or that the location of the addition of the nitrite-decreasing additive was not optimised.
  • Various embodiments of the invention may suitably comprise, consist of, or consist essentially of, appropriate combinations of the disclosed elements, components, features, parts, steps, means, etc., other than those specifically described herein.
  • this disclosure may include other inventions not presently claimed, but which may be claimed in future.

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  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Manufacture Of Tobacco Products (AREA)

Abstract

La présente invention concerne un matériau de génération d'aérosol comprenant un matériau de tabac et une source sélectivement libérable d'un additif de réduction des teneurs en nitrite. L'invention concerne également des produits consommables destinés à être utilisés dans un système de fourniture d'aérosol, comprenant un matériau de génération d'aérosol et une source sélectivement libérable d'un additif de réduction des teneurs en nitrite, ainsi que des systèmes de fourniture d'aérosol et des utilisations d'une source sélectivement libérable d'un additif de réduction des teneurs en nitrite pour réduire la génération de nitrosamines spécifiques du tabac lors du chauffage d'un matériau de génération d'aérosol.
PCT/EP2025/060848 2024-04-23 2025-04-22 Matériaux de génération d'aérosol, produits consommables et systèmes de fourniture d'aérosol Pending WO2025224051A1 (fr)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007010407A2 (fr) 2005-06-21 2007-01-25 V. Mane Fils Dispositif pour fumeur incorporant une capsule frangible, capsule frangible et procede de fabrication de ladite capsule
WO2014141201A2 (fr) * 2013-03-15 2014-09-18 Fall Safall Procédé de réduction des nitrosamines spécifiques du tabac
WO2019166640A1 (fr) * 2018-03-02 2019-09-06 Nicoventures Trading Limited Génération d'aérosol
WO2023012293A1 (fr) * 2021-08-04 2023-02-09 Nicoventures Trading Limited Produit pour stocker et distribuer des produits consommables destinés à être utilisés avec un dispositif de fourniture d'aérosol
EP4209136A1 (fr) * 2020-09-03 2023-07-12 Japan Tobacco Inc. Matériau de remplissage de tabac, inhalateur d'arôme de type chauffage sans combustion, et procédé de production d'un matériau de remplissage de tabac

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007010407A2 (fr) 2005-06-21 2007-01-25 V. Mane Fils Dispositif pour fumeur incorporant une capsule frangible, capsule frangible et procede de fabrication de ladite capsule
WO2014141201A2 (fr) * 2013-03-15 2014-09-18 Fall Safall Procédé de réduction des nitrosamines spécifiques du tabac
WO2019166640A1 (fr) * 2018-03-02 2019-09-06 Nicoventures Trading Limited Génération d'aérosol
EP4209136A1 (fr) * 2020-09-03 2023-07-12 Japan Tobacco Inc. Matériau de remplissage de tabac, inhalateur d'arôme de type chauffage sans combustion, et procédé de production d'un matériau de remplissage de tabac
WO2023012293A1 (fr) * 2021-08-04 2023-02-09 Nicoventures Trading Limited Produit pour stocker et distribuer des produits consommables destinés à être utilisés avec un dispositif de fourniture d'aérosol

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* Cited by examiner, † Cited by third party
Title
T. J. J. ADAMSON, FOOD AND CHEMICAL TOXICOLOGY, vol. 113, 2018, pages 337 - 344

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