[go: up one dir, main page]

WO2025215655A1 - Kit pour favoriser la pousse des cheveux - Google Patents

Kit pour favoriser la pousse des cheveux

Info

Publication number
WO2025215655A1
WO2025215655A1 PCT/IN2024/052281 IN2024052281W WO2025215655A1 WO 2025215655 A1 WO2025215655 A1 WO 2025215655A1 IN 2024052281 W IN2024052281 W IN 2024052281W WO 2025215655 A1 WO2025215655 A1 WO 2025215655A1
Authority
WO
WIPO (PCT)
Prior art keywords
amount
kit
extract
vitamin
hair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/IN2024/052281
Other languages
English (en)
Inventor
Rinky KAPOOR
Debraj SHOME
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2025215655A1 publication Critical patent/WO2025215655A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the present invention relates to a kit for promoting hair growth. More 10 particularly, the present invention relates to a kit for promoting hair growth and preventing hair loss, comprising (i) a first composition; (ii) a second composition; (iii) a third composition; (iv) a fourth composition; and (v) an instruction manual. The present invention further relates to a method of using the kit for promoting hair growth and preventing hair loss. 15 BACKGROUND AND PRIOR ART: Men and women around the world suffer from hair thinning and hair loss (alopecia). It is one of the major causes of concern for people all around the world.
  • Hair loss can be either temporary or permanent and can affect just the scalp or the whole body.
  • the most common types of hair 25 loss include male or female pattern baldness, alopecia areata, and telogen effluvium. As alopecia progresses, a transition occurs in areas approaching baldness, during which the hair itself changes from terminal to vellus type. It is known to reduce the size of hair follicles.
  • Hair loss can be caused by a variety of factors such as decreased hair root metabolic function, decreased hair function, reduced blood circulation, Alopecia Areata (AA), hormonal imbalance, drug side effects, stress, genetic factors and various nutritional deficiencies. Certain medications including chemotherapy, HIV/AIDS and hypothyroidism can also cause hair loss. Hair loss may also be 5 induced due to unhealthy lifestyle, heat or chemical hair treatments or textural inflictions to hair due to aggressive and repeated hair coloring and hair styling. Excessive styling and hair treatments can also cause hair loss. Examples of extreme styling include tight braids, hair weaves, cornrows, chemical relaxers to 10 straighten hair, hot oil treatments, or any kind of harsh chemical or high heat. Such practices affect the hair root, so hair may not grow back.
  • extreme styling include tight braids, hair weaves, cornrows, chemical relaxers to 10 straighten hair, hot oil treatments, or any kind of harsh chemical or high heat. Such practices affect the hair root, so hair may not grow back.
  • Medicinal treatments for alopecia include the drugs like Rogaine (minoxidil) and Propecia (finasteride).
  • Rogaine has been shown to reduce hair loss and promote hair growth in up to 10% of men with male pattern baldness.
  • treatment with it needs to be done regularly and has many side effects.
  • the treatment is also very expensive.
  • Finasteride is the active ingredient in Propecia (a trademark of 30 Merck & Co.) in tablet form and should be taken regularly.
  • Alopecia areata can be treated with steroid injections into the affected area, but these must be repeated frequently to be effective.
  • Surgical techniques such as Self-grafting or transplants, Flap surgery, Scalp 35 reductions and Scalp expansion and extension
  • Non- surgical techniques such 5 as additions of hair- bearing devices that can consist of human hair, synthetic fibre or a combination of both. These attachments are attached by a variety of techniques, and either existing hair or skin can be the fixation site.
  • US5750108 discloses a method for hair treatment and a kit for invigorating hair 10 growth.
  • the hair treatment kit comprises a first treatment solution comprising tea tree oil, a second treatment solution comprising chlorine dioxide, an acidic solution having a pH effective to release the oxygen from said chlorine dioxide in said second treatment solution, and a third treatment solution comprising saw palmetto berry extract.
  • WO2005004984A1 discloses a kit, device and a method for the treatment of a hair growth disorder, wherein the kit comprises: at least one formulation comprising a hair growth modulating agent; and at least one electrically powered device for promoting delivery of the hair growth modulating agent into and/or onto the body 20 area.
  • US8197856 discloses kit for promoting hair growth on areas of the scalp that has been affected by fungal infections.
  • the kit comprises of a first powdered mixture and three liquid compositions.
  • the elements of the kit are applied to the scalp of 25 an individual experiencing hair loss due to fungi.
  • the hair growth kits available in existing prior arts are expensive and have shown unsatisfactory results. The results also are short-lived and carry the risk of unwanted side effects.
  • kits for promoting hair growth that can improve hair growth, prevent hair loss, strengthen hair follicles and hydrate the hair and which is economical and easy to apply. 5
  • the present inventors have come up with a kit for prevention of early hair loss and promotion of hair growth.
  • Another object of the invention is to provide a kit for promotion of hair growth, prevention of hair loss and further strengthening and nourishment of hair.
  • the said 15 kit comprises constituents which are cost effective, non-toxic, biocompatible and hence favor prolonged use with minimal to no side effects.
  • the present invention provides a kit for promoting hair growth and preventing hair loss, comprising: i.
  • Vascular Endothelial Growth Factor25 (Human oligopeptide-11) including its biomimetic analogue Sh- Polypeptide-9, Basic Fibroblast Growth Factor (Human oligopeptide-3) including its biomimetic analogue Sh-Polypeptide-1, Insulin-like Growth Factor 1 (Human oligopeptide-2) including its biomimetic analogue Sh- Oligopeptide-2, Copper Tripeptide 1, Keratinocyte Growth Factor 30 including its biomimetic analogue Sh-Polypeptide-3, Thymosin- ⁇ 4 including its biomimetic analogue Sh-Oligopeptide-4; ii.
  • the first composition comprises; i.
  • Vascular endothelial growth factor Human oligopeptide-11 including its biomimetic analogue Sh-Polypeptide-9 in an amount of 0.01mg/L – 15 100mg/L; ii. Basic fibroblast growth factor (Human oligopeptide-3) including its biomimetic analogue Sh-Polypeptide-1 in an amount of 0.01mg/L – 100 mg/L; iii. Insulin like growth factor (Human oligopeptide-2) including its 20 biomimetic analogue Sh-Oligopeptide-2 in an amount of 0.01mg/L – 100mg/L; iv. Copper tripeptide 1 in an amount of 0.1mg/L – 500 mg/L; v.
  • the second composition comprises: i. Anagain in an amount of 0.5 - 3.0% w/w; 30 ii. Caffeine in an amount of 0.5 - 3.0% w/w; iii. Vitamin B5 in an amount of 0.2 – 1.0 % w/w; iv. Vitamin E in an amount of 0.01 – 0.5 % w/w; and v.
  • Citric acid in an amount of 0.005 – 0.05 % w/w together with pharmaceutically acceptable excipients and additives in a 35 suitable vehicle.
  • the pharmaceutically acceptable excipients of the second composition comprises: i. Polyquaternium 10 in an amount of 0.5 - 3.0% w/w; ii. Glycerin in an amount of 2.0 – 7.0 % w/w; 10 iii. Sodium lauryl ether sulphate in an amount of 30 – 60% w/w; iv. Sodium lauroyl sarcosinate in an amount of 1.0 – 3.0% w/w; v. Propylene glycol in an amount of 0.5 - 3.0% w/w; vi.
  • the additives of the second composition comprises: i. Kappaphycus alvarezii extract in an amount of 0.1 – 1.0 % w/w; 25 ii. Vaccinium macrocarpon fruit extract (Cranberry extract) in an amount of 0.1 – 1.0 % w/w; iii. Dextran Hydroxypropyltrimonium Chloride in an amount of 1.0 – 10 % w/w; and iv.
  • the third composition comprises: i. Niacinamide in an amount of 0.2 – 1.0 % w/w; ii. Onion Oil in an amount of 0.2 – 1.0 % w/w; iii. Procapil in an amount of 0.5 - 3.0% w/w; 35 iv. Anagain in an amount of 0.2 – 1.0 % w/w; 5 v. Redensyl in an amount of 0.05 – 0.5% w/w; vi. Saw Palmetto Oil in an amount of 0.2 – 1.0 % w/w; vii.
  • the pharmaceutically acceptable excipients of the third composition comprises: i. Glycerin in an amount of 2.0 – 7.0 % w/w; 15 ii. Phenoxyethanol and Ethylhexylglycerin in an amount of 0.5 – 3.0 % w/w; iii. Biosaccharide Gum-1 in an amount of 0.5 – 3.0 % w/w; iv.
  • the additives of the third composition comprises: i. Capixyl in an amount of 1.0 – 10 % w/w; ii. Aminexil in an amount of 0.5 – 5.0 % w/w; iii. Caffeine in an amount of 0.001 – 0.01 % w/w; 30 iv. Caprylic/capric triglyceride in an amount of 0.5 – 5.0 % w/w; v. Ginseng extract in an amount of 1.0 – 10 % w/w; and vi. Ginkgo biloba extract in an amount of 1.0 – 10 % w/w.
  • the fourth composition comprises nutraceuticals selected from the group comprising of vitamins, metal salts, plant extracts, amino acids, pigments, probiotics, Omega fatty acids and the like.
  • the fourth composition comprises: 10 i. Vitamins in an amount of 1-2 % w/w; ii. Metal salts in an amount of 0.2-0.5 % w/w; iii. Plant extracts in an amount of 5-8 % w/w; iv. Amino acids in an amount of 1-2 % w/w; v. Pigments in an amount of 0.2-0.5 % w/w; 15 vi. Probiotics in an amount of 0.1-0.2 % w/w; and vii.
  • the hair growth promoting kit of the present invention is useful for prevention of hair loss by stimulating hair follicles and promoting hair growth and strengthening and nourishing hair to protect the hair and enhance the overall health of the hair.
  • a kit for promoting hair growth, preventing hair loss and nourishing of hair follicles in mammals 25
  • the term ‘effective amount’ means an amount which stimulates hair growth associated with hair loss afflictions like male pattern baldness, or insults such as radiation or chemotherapy.
  • Source and Geographical Origin Material Source Geographical Origin Pisum Sativum Sprout South Korea Mediterranean Basin and the Near East Extract Larix Europaea Wood South Korea Mountains of Central Europe, in the Extract Alps and Carpathian Mountains and the Pyrenees Camellia Sinensis Leaf South Korea East Asia, probably originated in the Extract borderlands of north Burma and southwestern China Centella Asiatica leaf South Korea Tropical regions of Africa, Asia, extract Australia, and islands in the western Pacific Ocean Cranberry fruit dried South Korea Fen (marsh) lands of England extract Holy basil South Korea Indian subcontinent Fenugreek seed extract South Korea South Eastern Europe and West Asia Ginkgo biloba South Korea China Grape seed extract South Korea Central Asia Ashwagandha root South Korea India, northern Africa, and the Middle extract East Pumpkin seed extract South Korea Northeastern Mexico and Texas Brahmi leaf extract South Korea Southern and Eastern India, Australia, Europe, Africa, Asia, and North and South America Cinnamon bark extract South Korea Sri Lanka (formerly Ceylon), the neighbouring Malabar Coast of India, and Sri Lanka (formerly Ce
  • the present invention provides a kit for promoting hair growth and preventing hair loss, wherein the kit contains compositions comprising active ingredients together with pharmaceutically acceptable excipients that are mild, eco-friendly and prolong the anagen phase of hair cycle and prevent hair loss.
  • the kit of the present invention promotes hair growth, strengthens the hair follicles and hydrates the hair from the scalp to the tips.
  • the present hair growth promoting kit avoids the use of costly and harmful materials commonly used in hair growth kits of the art.
  • the present invention provides a kit for promoting hair growth and preventing hair loss, comprising: (i) a first composition (ii) a second composition, (iii) a third composition (iv) a fourth composition, and (v) an instruction manual.
  • the present invention provides a kit for promoting hair growth and preventing hair loss, comprising: i.
  • Vascular Endothelial Growth Factor Human oligopeptide-11
  • Basic Fibroblast Growth Factor Human oligopeptide-3
  • Insulin-like Growth Factor 1 Human oligopeptide-2
  • Copper Tripeptide Keratinocyte Growth Factor including its biomimetic analogue Sh-Polypeptide-3
  • Thymosin- ⁇ 4 including its biomimetic analogue Sh-Oligopeptide-4; ii.
  • the first composition comprises; 20 i.
  • Vascular endothelial growth factor Human oligopeptide-11 including its biomimetic analogue Sh-Polypeptide-9 in an amount of 0.01mg/L – 100mg/L; ii. Basic fibroblast growth factor (Human oligopeptide-3) including its biomimetic analogue Sh-Polypeptide-1 in an amount of 0.01mg/L – 100 25 mg/L; iii. Insulin like growth factor (Human oligopeptide-2) including its biomimetic analogue Sh-Oligopeptide-2 in an amount of 0.01mg/L – 100mg/L; iv. Copper tripeptide 1 in an amount of 0.1mg/L – 500 mg/L; 30 v.
  • the second composition comprises: 35 i. Anagain in an amount of 0.5 - 3.0% w/w; 5 ii. Caffeine in an amount of 0.5 - 3.0% w/w; iii. Vitamin B5 in an amount of 0.2 – 1.0 % w/w; iv. Vitamin E in an amount of 0.01 – 0.5 % w/w; and v.
  • Citric acid in an amount of 0.005 – 0.05 % w/w; together with pharmaceutically acceptable excipients and additives in a 10 suitable vehicle.
  • the pharmaceutically acceptable excipients of the second composition comprises: i. Polyquaternium 10 in an amount of 0.5 - 3.0% w/w; 15 ii. Glycerin in an amount of 2.0 – 7.0 % w/w; iii. Sodium lauryl ether sulphate in an amount of 30 – 60% w/w; iv. Sodium lauroyl sarcosinate in an amount of 1.0 – 3.0% w/w; v. Propylene glycol in an amount of 0.5 - 3.0% w/w; vi.
  • the active ingredient Anagain comprises of Pisum 30 sativam sprout extract and Phenoxyethanol and Aqua.
  • the additives of the second composition comprises: i. Kappaphycus alvarezii Extract in an amount of 0.1 – 1.0 % w/w; ii. Vaccinium macrocarpon Fruit Extract (Cranberry extract) in an amount of 35 0.1 – 1.0 % w/w; 5 iii.
  • the second composition of the present invention helps in arresting hair fall and 10 increasing the thickness and density of hair. It contains natural ingredients which help to activate hair follicles from the dormant phase and results in long, shiny and bouncy hair. It also helps in conditioning the hair.
  • the third composition of the kit comprises Niacinamide, Onion 15 Oil, Procapil, Anagain, Redensyl, Saw palmetto extract, Biotin and Melatonin as active ingredients, together with pharmaceutically acceptable excipients and additives in a suitable vehicle.
  • the third composition comprises: 20 i. Niacinamide in an amount of 0.2 – 1.0 % w/w; ii. Onion Oil in an amount of 0.2 – 1.0 % w/w; iii. Procapil in an amount of 0.5 - 3.0% w/w; iv. Anagain in an amount of 0.2 – 1.0 % w/w; v.
  • the active ingredient Anagain comprises of Pisum sativum (Pea) Sprout Extract, Alcohol and Aqua / Water.
  • the active ingredient Redensyl comprises of Glycerin, Sodium Metabisulfite, Larix Europaea Wood Extract, Glycine, Zinc Chloride, Camellia Sinensis Leaf Extract and Aqua.
  • the active ingredient Procapil comprises of Butylene 10 Glycol, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Apigenin, Oleanolic Acid, Biotinoyl Tripeptide-1 and Aqua.
  • the pharmaceutically acceptable excipients of the third composition include but not limited to Glycerin, Phenoxyethanol and 15 Ethylhexylglycerin, Biosaccharide Gum-1, Sodium Metabisulfite, Hydroxyethyl Cellulose, Xanthan Gum, Perfume, Benzyl Alcohol, Triethanolamine, Disodium EDTA and Aqua.
  • the pharmaceutically acceptable excipients of the 20 third composition comprises: i. Glycerin in an amount of 2.0 – 7.0 % w/w; ii. Phenoxyethanol and Ethylhexylglycerin in an amount of 0.5 – 3.0 % w/w; iii.
  • Biosaccharide Gum-1 in an amount of 0.5 – 3.0 % w/w; iv. Sodium Metabisulfite in an amount of 0.2 – 1.0 % w/w; 25 v. Hydroxyethyl Cellulose in an amount of 0.2 – 1.0 % w/w; vi. Xanthan Gum in an amount of 0.2 – 1.0 % w/w; vii. Perfume in an amount of 0.2 – 1.0 % w/w; viii. Benzyl Alcohol in an amount of 0.2 – 1.0 % w/w; ix. Triethanolamine in an amount of 0.1 – 0.5% w/w; 30 x.
  • the additives of the third composition comprises: i. Capixyl in an amount of 1.0 – 10 % w/w; 35 ii. Aminexil in an amount of 0.5 – 5.0 % w/w; 5 iii. Caffeine in an amount of 0.001 – 0.01 % w/w; iv. Caprylic/capric triglyceride in an amount of 0.5 – 5.0 % w/w; v. Ginseng extract in an amount of 1.0 – 10 % w/w; and vi.
  • the fourth composition comprises nutraceuticals including but not limited to vitamins, metal salts, plant extracts, amino acids, pigments, probiotics, Omega fatty acids and the like.
  • the fourth composition comprises: 15 i. Vitamins in an amount of 1-2 % w/w; ii. Metal salts in an amount of 0.2-0.5 % w/w; iii. Plant extracts in an amount of 5-8 % w/w; iv. Amino acids in an amount of 1-2 % w/w; v. Pigments in an amount of 0.2-0.5 % w/w; 20 vi.
  • the vitamins of the fourth composition are selected from the group consisting of Vitamin B1, Vitamin B2, Vitamin B3, Vitamin B5, Vitamin B6, Vitamin B7, Vitamin B9, Vitamin B12, Vitamin C, Vitamin D2, 25 Vitamin E and the like.
  • the metal salts of the fourth composition are selected from the group consisting of Magnesium oxide, dicalcium phosphate, calcium, phosphorus, ferrous bisglycinate, zinc sulphate and the like.
  • the plant extracts of the fourth composition are selected from the group consisting of Centella asiatica leaf extract, Cranberry fruit dried extract, Holy basil, Fenugreek seed extract, Ginkgo biloba, grape seed extract, ashwagandha root extract, pumpkin seed extract, Brahmi leaf extract, 5 Cinnamon bark extract, coconut powder, ginger rhizome extract, Glycyrrhiza glabra extract, rose mary leaves extract, Beta sitosterol and the like.
  • the amino acids of the fourth composition are selected from the group consisting of N-Acetyl-Cysteine, L-Ornithine, L-lysine HCl, L- 10 Histidine HCl and the like.
  • the pigments of the fourth composition are selected from the group consisting of Lutein, Chromium picolinate, lycopene, Citrus bioflavonoids, and the like.
  • the omega fatty acids of the fourth composition are selected from Omega 3 fatty acid, gamma-linoleic acid and the like.
  • the probiotics of the fourth composition are selected 20 from Lactobacillus acidophilus and the like. The supplements present in the fourth composition protect the hair, boost hair growth and enhances the overall health of the hair.
  • present invention provides a process for the preparation of the first composition which includes mixing the components and water at a temperature of 25°C in a disperser, adjusting the pH and filtering the final product using a 500 MESH micron filter system as depicted in figure 1.
  • present invention provides a process for the preparation of the second composition which includes adding the components in the right proportions of Anagain, Caffeine, Vitamin B5, Vitamin E and Citric acid, together with pharmaceutically acceptable excipients and additives in a suitable vehicle, wherein the ingredients are added in proportion in the composition to achieve the 35 desired effect.
  • present invention provides a process for the preparation of the third composition which includes adding the components in the right proportions of Niacinamide, Onion Oil, Procapil, Anagain, Redensyl, Saw Palmetto Oil, Biotin and Melatonin, together with pharmaceutically acceptable 10 excipients and additives in a suitable vehicle, wherein the ingredients are added in proportion in the composition to achieve the desired effect.
  • present invention provides a process for the preparation of the fourth composition which includes adding the components in 15 the right proportions of Vitamins, Metal salts, Plant extracts, Amino acids, Pigments, Probiotics and Omega fatty acids in a suitable vehicle, wherein the ingredients are added in proportion in the composition to achieve the desired effect.
  • the first composition of the present invention comprises; i. Vascular endothelial growth factor (Human oligopeptide-11) including its biomimetic analogue Sh-Polypeptide-9 in an amount of 5 mg/L; ii. Basic fibroblast growth factor (Human oligopeptide-3) including its biomimetic analogue Sh-Polypeptide-1 in an amount of 2 mg/L; 25 iii. Insulin like growth factor (Human oligopeptide-2) including its biomimetic analogue Sh-Oligopeptide-2 in an amount of 2 mg/L; iv. Copper tripeptide 1 in an amount of 10 mg/L; v.
  • the second composition comprises: i. Anagain in an amount of 1.0% w/w; 35 ii. Caffeine in an amount of 1.0% w/w; 5 iii. Vitamin B5 in an amount of 0.5% w/w; iv. Vitamin E in an amount of 0.1% w/w; and v. Citric acid in an amount of 0.01% w/w; together with pharmaceutically acceptable excipients and additives in a suitable vehicle.
  • the pharmaceutically acceptable excipients of the second composition comprises: i. Polyquaternium 10 in an amount of 1.0% w/w; ii. Glycerin in an amount of 5.0% w/w; 15 iii. Sodium lauryl ether sulphate in an amount of 45.0% w/w; iv. Sodium lauroyl sarcosinate in an amount of 2.0% w/w; v. Propylene glycol in an amount of 1.0% w/w; vi. Phenoxyethanol and Ethylhexylglycerin in an amount of 0.1% w/w; vii. Biosaccharide Gum-1 in an amount of 0.5% w/w; 20 viii.
  • the active ingredient Anagain comprises of Pisum sativam sprout extract and Phenoxyethanol and Aqua.
  • the additives of the second composition comprises: i.
  • the third composition comprises: i. Niacinamide in an amount of 0.5% w/w; ii. Onion Oil in an amount of 0.5% w/w; 10 iii. Procapil in an amount of 1.0% w/w; iv. Anagain in an amount of 0.5% w/w; v.
  • the pharmaceutically acceptable excipients of the third 20 composition comprises: i. Glycerin in an amount of 5.0 % w/w; ii. Phenoxyethanol and Ethylhexylglycerin in an amount of 1.0% w/w; iii. Biosaccharide Gum-1 in an amount of 1.0% w/w; iv.
  • Procapil strengthens the 35 hair by increasing the nutrition supply to the hair roots. Anagain prolongs the 5 anagen phase of hair cycle, therefore preventing premature shedding of hair. Niacinamide promotes circulation and improves the look and feel of hair by smoothness and shine. It also improves the texture of physically/chemically damaged hair by helping build keratin. Onion Oil which is rich in sulfur prevents breakage, split ends and thinning of hair. 10
  • the active ingredient Anagain comprises of Pisum sativum (Pea) Sprout Extract, Alcohol and Aqua / Water.
  • the active ingredient Redensyl comprises of Glycerin, 15 Sodium Metabisulfite, Larix Europaea Wood Extract, Glycine, Zinc Chloride, Camellia Sinensis Leaf Extract and Aqua.
  • the active ingredient Procapil comprises of Butylene Glycol, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Apigenin, 20 Oleanolic Acid, Biotinoyl Tripeptide-1 and Aqua.
  • the additives of the third composition comprises: i. Capixyl in an amount of 5.0% w/w; ii. Aminexil in an amount of 1.5% w/w; 25 iii.
  • the fourth composition comprises: i. Vitamins in an amount of 1.5 % w/w; ii. Metal salts in an amount of 0.3 % w/w; iii. Plant extracts in an amount of 6 % w/w; iv. Amino acids in an amount of 1.5 % w/w; 35 v. Pigments in an amount of 0.3 % w/w; 5 vi.
  • the plant extracts of the fourth composition are selected from the group consisting of Centella Asiatica leaf extract, Cranberry fruit dried extract, Holy basil, Fenugreek seed extract, Ginkgo biloba, grape seed 20 extract, ashwagandha root extract, pumpkin seed extract, Brahmi leaf extract, Cinnamon bark extract, coconut powder, ginger rhizome extract, glycyrrhiza glabra extract, rose mary leaves extract, Beta sitosterol and the like.
  • the amino acids of the fourth composition are selected25 from the group consisting of N-Acetyl-Cysteine, L-Ornithine, L-lysine HCl, L- Histidine HCl and the like.
  • the pigments of the fourth composition are selected from the group consisting of Lutein, Chromium picolinate, lycopene, Citrus 30 bioflavonoids, and the like.
  • the omega fatty acids of the fourth composition are selected from Omega 3 fatty acid, gamma-linoleic acid and the like.
  • the probiotics of the fourth composition are selected from Lactobacillus acidophilus and the like.
  • the first composition may be formulated in the form of a solution in a vial, or more preferably may be formulated as prefilled syringes for 10 better penetration into the scalp.
  • the second composition may be formulated in the form of serum, shampoo, hair oil, lotion, gels, spray, cream, tablets, capsules and the like; more preferably as shampoo.
  • the third composition may be formulated in the form of serum, shampoo, hair oil, lotion, gels, spray, cream, tablets, capsules and the like; more preferably as serum.
  • the fourth composition may be formulated in the form of serum, shampoo, hair oil, lotion, gels, spray, cream, tablets, capsules, syrup and the like; more preferably as tablets or capsules.
  • the hair growth promoting kit minimizes hair breakage 25 and split ends and nourishes the hair roots thereby prevents hair loss and improves hair growth.
  • the method of promoting hair growth and preventing early hair loss and for strengthening, nourishing, rejuvenating hair to improve the bodily 30 appearance of a person comprises applying the compositions provided in the kit as directed in the instruction manual. Accordingly, the method comprises the following steps: i. Administering the first composition through standard microneedling techniques including but not limited to dermaroller, dermapen, dermatok, 35 MNRF; 5 ii. Applying the second composition topically, in a suggested volume of 2- 3mL, twice daily; iii. Applying the third composition topically before rinsing hair with water, by gently massaging onto the scalp followed by thoroughly washing off the scalp; and 10 iv.
  • the hair growth promoting kit is useful in the prevention of early hair loss by stimulating hair follicles, strengthening, nourishing, 15 rejuvenating and retention of hair to improve the bodily appearance of a person.
  • the compositions of the hair growth promoting kit of the present invention are stable and do not produce any harmful/ side effects on application to the scalp. 20
  • the present kit for promoting hair growth has the following advantages: ⁇ Nourishes the hair roots and strengthens the hair follicles. ⁇ Prolongs the hair growth phase and promotes hair growth. ⁇ Improves hair shaft thickness to give more voluminous hair.
  • Example 1a Preparation of the first composition: 5 The process for the preparation of the first composition which includes the following steps: 1) The solvent i.e. water at a temperature of 25°C is added with the conditioning ingredients of the composition to the disperser; 2) The disperser is set at 800 rpm for 30 minutes.
  • Example 1b 15 Table 1: First composition Sr. Name of Ingredient Concentration No. 1 Vascular Endothelial Growth Factor (Human 5 mg/L oligopeptide-11) including its biomimetic analogue Sh-Polypeptide-9 2 Basic Fibroblast Growth Factor (Human 2 mg/L oligopeptide-3) including its biomimetic analogue Sh-Polypeptide-1 3 Insulin-like Growth Factor 1 (Human 2 mg/L oligopeptide-2) including its biomimetic analogue Sh-Oligopeptide-2 4 Copper Tripeptide 1 10 mg/L 5 Keratinocyte Growth Factor including its 1 mg/L biomimetic analogue Sh-Polypeptide-3 6 Thymosin- ⁇ 4 including its biomimetic analogue 0.01 mg/L Sh-Oligopeptide-4
  • Example 2a Pregnenupramine fibroblast Growth Factor (Human 5 mg/L oligopeptide-11) including its biomimetic analogue Sh-Polypeptide-9 2
  • Example 2b 15 1.0% w/w of Anagain, 1.0% w/w of Caffeine, 0.5% w/w of Vitamin B5, 0.1% w/w of Vitamin E, 0.01% w/w of Citric acid, 1.0% w/w of Polyquaternium 10, 5.0% w/w of Glycerin, 45.0% w/w of Sodium lauryl ether sulphate, 2.0% w/w of Sodium lauroyl sarcosinate, 1.0% w/w of Propylene glycol, 0.1% w/w of Phenoxyethanol and Ethylhexylglycerin, 0.5% w/w of Biosaccharide Gum-1, 20 0.5% w/w of Sodium chloride, 0.5% w/w of Cyclopentasiloxane and Dimethiconol, 1.0% w/w of Perfume, 0.1% w/w of Pearl powder, 0.1% w/w/w
  • Table 2 Second composition Sr. No. Name of Ingredient Concentration 1 Anagain 1.0% w/w 2 Caffeine 1.0% w/w 3 Polyquaternium 10 1.0% w/w 4 Glycerin 5.0% w/w 5 Sodium lauryl ether sulphate 45.0% w/w 6 Sodium lauroyl sarcosinate 2.0% w/w 7 Propylene glycol 1.0% w/w 8 Phenoxyethanol and Ethylhexylglycerin 0.1% w/w 9 Biosaccharide Gum-1 0.5% w/w 10 Sodium chloride 0.5% w/w 11 Cyclopentasiloxane and Dimethiconol 0.5% w/w 12 Perfume 1.0% w/w 13 Vitamin B5 0.5% w/w 14 Pearl powder 0.1% w/w 15 White powder 0.1% w/w 16 Vitamin E 0.1% w/w 17 Disodium EDTA 0.1% w/
  • Example 3b Preparation of the third composition: 0.5% w/w of Niacinamide, 0.5% w/w of Onion Oil, 1.0% w/w of Procapil, 0.5% w/w of Anagain, 0.1% w/w of Redensyl, 0.5% w/w of Saw Palmetto Oil, 0.1% w/w of Biotin, 0.01% w/w of Melatonin, 5.0 % w/w of Glycerin, 1.0% w/w of 15 Phenoxyethanol and Ethylhexylglycerin, 1.0% w/w of Biosaccharide Gum-1, 0.5% w/w of Sodium Metabisulfite, 0.5% w/w of Hydroxyethyl Cellulose, 0.5% w/w of Xanthan Gum, 0.5% w/w of Perfume, 0.5% w/w of Benzyl Alcohol, 0.2% w/w/w
  • Table 4 Third composition Sr. No. Name of Ingredient Concentration 1 Procapil 1.0% w/w 2 Anagain 0.5% w/w 3 Redensyl 0.1% w/w 4 Niacinamide 0.5% w/w 5 Onion Oil 0.5% w/w 6 Saw Palmetto Oil 0.5% w/w 7 Biotin 0.1% w/w 8 Melatonin 0.01% w/w 9 Glycerin 5.0 % w/w 10 Phenoxyethanol and Ethylhexylglycerin 1.0% w/w 11 Biosaccharide Gum-1 1.0% w/w 12 Sodium Metabisulfite 0.5% w/w 13 Hydroxyethyl Cellulose 0.5% w/w 14 Xanthan Gum 0.5% w/w 15 Perfume 0.5% w/w 16 Benzyl Alcohol 0.5% w/w 17 Triethanolamine 0.2% w/w 18 Disodium EDTA 0.1%
  • Example 4b 5 Vitamins, metal salts, plant extracts, amino acids, pigments, probiotics and Omega fatty acid added to 1 litre of distilled water, further disclosed in Table 6. The composition was then biologically sterilized and bottled. Table 6: Fourth composition Sr.
  • Vitamin B3 18 mg 100% (Nicotinamide) Vitamin E (D alpha 10 mg 100% tocopheryl acetate) Ginkgo Biloba Dried 5 mg ** Leaves Extract Vitamin B5 (Calcium 4 mg 80% Pantothenate) Vitamin B6 (Pyridoxine 2 mg 83.3% HCl) Cupric Sulphate 2 mg 46.83% Vitamin B2 1.6 mg 64% (Riboflavin) Vitamin B1 (Thiamin 1.4 mg 77.7% Mononitrate) Manganese Sulphate 0.5 mg 4.54% Lactic Acid Bacillus 0.5 mg ** Vitamin A (Retinyl 0.3 mg 30% Palmitate) Vitamin B9 (Folic Acid) 176.5 mcg 100% Vitamin K1 30 mcg 54.5% (Phylloquinone) Chromium Picolinate 25 m
  • the average number of hair pulled at baseline was 10.5, which reduced to 4 at 3 months and 2.35 at 6 months. Indicating a negative hair-pull test post-therapy.
  • 2) Increase in hair growth Global photographic assessment of subjects 15 undergoing therapy was conducted at baseline, 3 months and 6 months. The global photography assessment score was 4.5 at baseline, which gradually increased to 6 at 3 months and 8 at 6 months.
  • 3) Increase in terminal hair count Videomicroscopic assessment was 20 conducted. There was significant increase in terminal hair count and decrease in the vellus hair count in 82% of the subjects.
  • Hair Shaft Diameter The average hair shaft diameter for each patient, taken at 15 cm from the glabella, 57% patients had an increase in the width 25 of their hairs.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne un kit pour favoriser la pousse des cheveux et prévenir la chute des cheveux, comprenant (i) une première composition ; (ii) une deuxième composition ; (iii) une troisième composition ; (iv) une quatrième composition et (v) un manuel d'instruction. L'invention concerne également un procédé d'utilisation du kit pour favoriser la pousse des cheveux et prévenir la chute des cheveux.
PCT/IN2024/052281 2024-04-08 2024-11-23 Kit pour favoriser la pousse des cheveux Pending WO2025215655A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN202421028659 2024-04-08
IN202421028659 2024-04-08

Publications (1)

Publication Number Publication Date
WO2025215655A1 true WO2025215655A1 (fr) 2025-10-16

Family

ID=97349582

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2024/052281 Pending WO2025215655A1 (fr) 2024-04-08 2024-11-23 Kit pour favoriser la pousse des cheveux

Country Status (1)

Country Link
WO (1) WO2025215655A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013190567A2 (fr) * 2012-06-19 2013-12-27 Shome Debraj Composition et procédé pour une solution de croissance capillaire intradermique
IN202321053030A (fr) * 2023-08-08 2023-10-06

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013190567A2 (fr) * 2012-06-19 2013-12-27 Shome Debraj Composition et procédé pour une solution de croissance capillaire intradermique
IN202321053030A (fr) * 2023-08-08 2023-10-06

Similar Documents

Publication Publication Date Title
AU2004218468B2 (en) Method for increasing hair growth
US8715714B2 (en) Uses of rare earth elements for hair improvement
KR100963792B1 (ko) 한약재를 이용한 탈모 방지 및 발모 조성물을 함유하는 샴푸
KR100893106B1 (ko) 발모용 조성물
KR100960054B1 (ko) 탈모방지 및 두피개선을 위한 두발 화장품 조성물
US5384123A (en) Topical composition and method for rejuvenating skin
CN112870333A (zh) 一种改善人脱发生发的组合物、制剂及制备方法和应用
KR20140107784A (ko) 탈모 방지 및 모발 성장 촉진용 조성물
EP2066289A1 (fr) Utilisations d'éléments terres rares pour le traitement capillaire
JPH01313414A (ja) 頭部化粧料
EP1066015B1 (fr) Composition topique liquide favorisant la pousse des cheveux et son procede de fabrication
US7713557B2 (en) Natural oriental medicinal composition for the promotion of hair growth and method of preparing the same
CN113134089A (zh) 一种含有生物多糖的组合物及其应用
KR100970126B1 (ko) 탈모방지 및 발모촉진용 조성물의 제조방법
WO2025215655A1 (fr) Kit pour favoriser la pousse des cheveux
KR100664400B1 (ko) 탈모예방 및 양모(養毛) 조성물
CN100525744C (zh) 修复霜
KR20090022224A (ko) 두피보호 및 모발생장을 촉진하는 화장료 조성물
US20240251900A1 (en) Patch for targeted delivery of hair composition and method for applying same
WO2007034323A1 (fr) Composition destinee a etre utilisee dans le traitement de la calvitie, l'eclaircissage et la perte de cheveux et procede associe
JP2004161639A (ja) 白髪防止剤
JPH11302128A (ja) 頭皮頭髪用化粧料
Bhardwaj et al. HERBAL HAIR GEL: FORMULATION AND EVALUATION OF PHYSICAL PARAMETERS
CN120241565A (zh) 一种中药植物黑色素染发剂的制备及染发的方法
Janowiak et al. A Practitioner's Guide to Hair Loss Part 1—History, Biology, Genetics, Prevention, Conventional Treatments, and Herbals

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 24934366

Country of ref document: EP

Kind code of ref document: A1