WO2025214990A1

WO2025214990A1 - Aerosol-generating article with formaldehyde reduction

Info

Publication number: WO2025214990A1
Application number: PCT/EP2025/059540
Authority: WO
Original assignee: Swm Holdco Luxembourg
Current assignee: Swm Holdco Luxembourg
Priority date: 2024-04-08
Filing date: 2025-04-08
Publication date: 2025-10-16
Anticipated expiration: 2026-10-08
Also published as: EP4631371A1

Abstract

The present invention relates to an aerosol-generating article that produces an aerosol with reduced amount of formaldehyde.

Description

Title: Aerosol-generating article with formaldehyde reduction.

Technical Field

[0001] This disclosure pertains to the field of aerosol-generating article, in particular Heat-not-Burn (HnB) sticks.

Background Art

[0002] A large number of aerosol-generating systems for heating tobacco without burning it has been developed in order to avoid the formation of harmful constituents during combustion of the tobacco. By way of example, mention may be made of the applications published under numbers WO 2016/026810 and WO 2016/207407 which describe such systems.

[0003] These systems work in conjunction with aerosol-generating articles. An aerosol-generating article comprises an aerosol-generating zone, an aerosol-filtering zone and a cooling zone for connecting the aerosol-generating zone and the aerosol-filtering zone. For example, the aerosolgenerating zone includes an aerosol-generating substrate comprising reconstituted tobacco sheet and an aerosol-generating agent.

[0004] The user inserts the aerosol-generating article into a lodging of the aerosol-generating system and then the aerosol-generating zone of said article containing the aerosol generating substrate is heated to a temperature below the combustion temperature of the aerosol-generating substrate, thereby generating an aerosol comprising the flavours and nicotine. The aerosol replaces cigarette smoke and has advantageous organoleptic properties when it is inhaled by the user. This thus allows the user to inhale the flavours while at the same time very significantly reducing the exposure of the user to the harmful constituents of the smoke.

[0005] It is known that carbonyl compounds, in particular unwanted formaldehyde, can be formed when burning tobacco in traditional cigarettes. However, carbonyl compounds, in particular unwanted formaldehyde, may also be formed when heating the aerosol-generating substrate without burning it.

Technical problem

[0006] Therefore, there is a need for reducing, in some cases, the amount of formaldehyde into the aerosol produced by heating of the aerosol-generating substrate without burning it.

[0007] It is thus to the credit of the inventors to have found that it is possible to meet this need by means of the addition of a compound having amino functional group to a zone of an aerosolgenerating article.

Summary

[0008] It is proposed an aerosol-generating article comprising:

- an aerosol-generating zone comprising an aerosol-generating substrate,

- an aerosol-filtering zone comprising a filter media, and - a cooling zone between the aerosol-generating zone and the aerosol-filtering zone, wherein the aerosol-generating substrate has a pH from 4.9 to 7.0, in particular from 5.0 to 6.0 and comprises:

- a fibrous support comprising cellulosic fibers, plant fibers or a mixture thereof,

- an aerosol-generating agent,

- nicotine, a salt of nicotine or a mixture thereof, wherein the cooling zone is defined by an inner wall of a paper tube, said cooling zone being empty or comprising an aerosol property modifying element, and characterized in that it further comprises a compound having amino functional group in the aerosolgenerating substrate, in the filter media, at the inner wall of the paper tube, in the aerosol property modifying element or a combination thereof.

[0009] Advantageously, the aerosol generated by the aerosol-generating article comprises a reduced amount of formaldehyde in comparison with an aerosol generated by an aerosol-generating article which does not comprise the compound having amino functional group.

[0010] Without wishing to be bound by any theory, the inventors are of the opinion that the compound having amino functional group:

- may react via the nitrogen atom with the formaldehyde of the aerosol, or

- may limit, or even may prevent, the formation of the formaldehyde during the generation of the aerosol from the aerosol-generating substrate.

Thus, the compound having amino functional group may serve as a carbonyl compound scavenger.

[0011] Moreover, in above mentioned ranges of pH of the aerosol-generating substrate, said aerosolgenerating substrate generates an aerosol providing nicotine in a satisfactory manner and having no unpleasant harshness and acidic taste, i.e. an aerosol which is satisfactory to the user.

[0012] The structure of nicotine is such that it comprises two nitrogen atoms that are capable of accepting protons from an acid and, accordingly, nicotine can be present in neutral form (the nonprotonated form), monoprotonated form, and/or diprotonated form. Without wishing to be bound to any theory, the inventors are of the opinion that the advantageous organoleptic properties of the aerosol may be explained by:

- the monoprotonated form of nicotine being the main form of nicotine in the aerosolgenerating substrate having the pH from 4.9 to 7.0, in particular from 5.0 to 6.0. The monoprotonated form of nicotine is stable during the manufacture and the storage of the aerosol-generating article of the present invention. Moreover, the monoprotonated form of nicotine is efficiently released in the aerosol during the use of the aerosol-generating article of the present invention in a aerosolgenerating system and is known to have a physiological absorption profile comparable to a classical cigarette,

- the increase of the proportion of the neutral form of nicotine in an aerosol-generating substrate having a pH above 7. The neutral form is volatile and thus is easily released during the manufacturing and mainly during the storage of an aerosol-generating article comprising said aerosol-generating substrate. Moreover, the neutral form gives more irritation and has a slower physiological effect than the monoprotonated form.

[0013] Moreover, the aerosol generated from an aerosol-generating substrate having a pH below 4.9 has an unpleasant, harsh and pungent taste and may even have deleterious physiological effects in certain cases due to an increase of the amount of organic acid in said aerosol-generating substrate.

[0014] It is also proposed a method for producing an aerosol-generating article as defined above comprising the following steps: a) producing the aerosol-generating substrate, b) producing the filter media, and c) forming the cooling zone between the aerosol-generating zone and the aerosol-filtering zone by: wrapping a wrap paper around a portion of, in particular all the aerosol-generating substrate and a portion of, in particular all the filter media thereby obtaining the aerosol-generating article, wherein the wrap paper at the cooling zone forms the paper tube, or placing a paper tube between the aerosol-generating substrate and the filter media, then wrapping a wrap paper around a portion of, in particular all the aerosol-generating substrate, the paper tube and a portion of, in particular all the filter media thereby obtaining the aerosol-generating article, characterized in that the aerosol-generating substrate produced during step a), the filter media produced during step b), the cooling zone formed during step c) or a combination thereof comprises the compound having amino functional group.

[0015] It is also proposed an aerosol-generating substrate having a pH from 4.9 to 7.0, in particular from 5.0 to 6.0, and comprising:

- an aerosol-generating agent,

- nicotine, a salt of nicotine or a mixture thereof, and

- optionally a plant extract, an organic acid or a mixture thereof, characterized in that it comprises a compound having amino functional group.

[0016] It is also proposed a filter media for an aerosol-generating article, characterized in that it comprises a compound having amino functional group.

[0017] It is also proposed a paper tube for an aerosol-generating article, the paper tube having an inner wall defining an internal space, the internal space being empty or comprising an aerosol property modifying element, characterized in that it further comprises a compound having amino functional group at the inner wall, in the aerosol property modifying element or a combination thereof.

Brief Description of Drawings

[0018] Other features, details and advantages will be shown in the following detailed description and on the figures, on which: Fig. 1

[0019] [Fig. 1] is a schematic of the aerosol-generating article according to an embodiment of the invention.

Description of Embodiments

[0020] It is now referred to [Fig. 1].

[0021] It is proposed an aerosol-generating article 1 comprising:

- an aerosol-generating zone 11 comprising an aerosol-generating substrate 111 ,

- an aerosol-filtering zone 12 comprising a filter media 121 , and

- a cooling zone 13 between the aerosol-generating zone 11 and the aerosol-filtering zone 12, wherein the aerosol-generating substrate 111 has a pH from 4.9 to 7.0, in particular from 5.0 to 6.0 and comprises:

- an aerosol-generating agent,

- nicotine, a salt of nicotine or a mixture thereof, wherein the cooling zone 13 is defined by an inner wall of a paper tube 131 , said cooling zone 13 being empty or comprising an aerosol property modifying element and characterized in that it further comprises a compound having amino functional group in the aerosolgenerating substrate 111 , in the filter media 121 , at the inner wall of the paper tube 131 , in the aerosol property modifying element or a combination thereof.

[0022] For the purposes of the present application, the term “aerosol-generating article” denotes an article that can create an aerosol. The aerosol-generating article 1 is intended to be inserted into an aerosol generating system to deliver an aerosol to a user.

In particular, the aerosol-generating zone 11 is heated by the heating body of the aerosol generating system so that an aerosol is produced from the aerosol-generating substrate 111. The aerosol is cooled in the cooling zone 13 then filtered in the aerosol-filtering zone 12 before being delivered to the user. The aerosol-generating article 1 may comprise a wrap paper around the aerosol-generating substrate 111 , the paper tube 131 or forming the paper tube 131 and the filter media 121. The aerosol-generating article 1 may comprise a mouth end through which, in use, the aerosol exits the aerosol-generating article 1 and is delivered to the user.

[0023] Forthe purpose of the present application, the term “compound having amino functional group” denotes an inorganic or organic compound comprising group such as ammonia, primary amine, secondary amine and amide. Advantageously, the nucleophile amino functional group may react with any formaldehyde formed upon heating of the aerosol-generating substrate 111 or with its chemical precursors.

[0024] For example, the compound having amino functional group may be an amino acid, a peptide, a protein, an amino sugar, urea, an urea derivative, an amino polysaccharide, an inorganic ammonium compound, a nitrogen-containing polymer, a polyamine or a mixture thereof, in particular an amino acid, an amino sugar, an amino polysaccharide or a mixture thereof, more particularly an amino acid.

[0025] The amino acid may be glutamic acid, aspartic acid, alanine, asparagine, isoleucine, lysine, glycine, cysteine, arginine, homocysteine, isoleucine, leucine, glutamine, methionine, phenylalanine, histidine, proline, serine, valine, threonine or a mixture thereof, in particular aspartic acid, glutamic acid, glutamine, asparagine, glycine or a mixture thereof, more particularly aspartic acid, glutamic acid, glycine or a mixture thereof.

[0026] The amino acid may be under its acidic form, under its salt form or a mixture thereof. The carboxylate form such as sodium glycinate is an example of salt form of the amino acid.

[0027] Advantageously, the amino acid may be under its acidic form in the aerosol-generating substrate 111 to confer its pH to said aerosol-generating substrate 111.

[0028] The amino acid may be under its salt form at the inner wall of the paper tube 131 , in the aerosol property modifying element of the cooling zone 13 and in the filter media 121 of the aerosolfiltering zone 12. Advantageously, the salt form may be more reactive than the acidic from in cooling zone 13 and the aerosol-filtering zone 12.

[0029] The peptide may be glutamine peptide such as hydrolyzed whey protein, polyglutamic acid peptide, glycine soja peptide or a mixture thereof, in particular polyglutamic acid peptide.

[0030] The protein may be basic proteins hydrolysates, protein fibers, glycoprotein or a mixture thereof, in particular protein fibers or a mixture thereof. Casein fibers, soja fibers or a mixture thereof are examples of protein fibers particularly suitable as compound having amino functional group in the aerosol-generating article 1.

[0031] The amino sugar may be glucosamine, galactosamine, trehalosamine or a mixture thereof, in particular glucosamine, galactosamine or a mixture thereof, more particularly glucosamine.

[0032] The amino polysaccharide may be chitin, chitosan, amino cellulose, amino chitosan, aminoethylcellulose, etherified starch with alkylamine, regenerated cellulose spun with a polyamine or a mixture thereof, in particular chitosan, amino cellulose or a mixture thereof.

[0033] The regenerated cellulose spun with a polyamine can be viscose spun with a polyamine, lyocell spun with a polyamine or a mixture thereof.

[0034] The inorganic ammonium compound may be an ammonium salt, an ammonium phosphate, a ammonium metal phosphates or a mixture thereof, in particular diammonium phosphate, triammonium phosphate, ammonium hydrogen phosphate, ammonium dihydrogen phosphate, ammonium alkaline earth metal phosphate, ammonium chloride, ammonium iodide, ammonium hydroxide, ammonium nitrate, ammonium sulfate, ammonium hydrogensulfate or a mixture thereof, more particularly diammonium phosphate.

[0035] Ammonium tartrate dibasic, ammonium potassium tartrate, ammonium benzoate, ammonium lactate, ammonium salicylate, diammonium malate, ammonium borate, diammonium tetraborate, ammonium acetate, ammonium adipate, diammonium carbonate, ammonium hydrogen carbonate, diammonium oxalate , triammonium citrate, ammonium citrate dibasic, ammonium citrate monobasic, ammonium formate, ammonium alginate, ammonium carbamate, ammonium glycyrrhizate, ammonium glutamate or a mixture thereof are example of ammonium salt that can be used as compound having amino functional group in the aerosol-generating article 1.

[0036] The nitrogen-containing polymer may be polyethylene-imine, polystyrene-acrylonitrile, polyacrylonitrilebutadiene-styrene or a mixture thereof, in particular polyethylene-imine.

[0037] The polyamine may be alkyl amine, alkyl diamine, fatty alkyl diamine or a mixture thereof, more particularly fatty alkyl diamine.

[0038] The compound having amino functional group is in the aerosol-generating substrate 111 , in the filter media 121 , at the inner wall of the paper tube 131 or a combination thereof. The chemical composition and the quantity of the compound having amino functional group may depend on its location in the aerosol-generating article 1.

[0039] The aerosol-generating substrate 111 may comprise a compound having amino functional group chosen from glutamic acid, aspartic acid, glutamine, glycine, a salt of glycine, polyglutamic acid peptide, casein fibers, soja fibers, glucosamine or a mixture thereof, in particular glutamic acid, aspartic acid, glycine, a salt of glycine or a mixture thereof.

[0040] In certain circumstances, the aerosol-generating substrate 111 may comprise a compound having amino functional group chosen from glutamine, glycine, a salt of glycine, polyglutamic acid peptide, casein fibers, soja fibers, glucosamine or a mixture thereof, in particular glycine, a salt of glycine or a mixture thereof.

[0041] The salt of glycine may be sodium glycinate.

[0042] The total content by weight of solids of compound having amino functional group in the aerosol-generating substrate 111 may be from 0.3% to 25%, in particular from 0.4% to 20%, more particularly from 0.4% to 15%.

[0043] Indeed, the compound having amino functional groups of this list and/or a content in these ranges are adapted to the aerosol-generating substrate 111 because these compounds will help to adjust the pH of aerosol-generating substrate 111 in the requested range and the amino functional group may react with formaldehyde thereby reducing the amount of formaldehyde in the aerosol generated.

[0044] The cooling zone 13 may comprise a compound having amino functional group chosen from a salt of glycine, amino cellulose, polyethylene-imine, fatty alkyl diamine or a mixture thereof.

[0045] The total content by weight of solids of compound having amino functional group in the cooling zone 13 may be from 1 % to 40%, in particular from 4% to 30%, more particularly from 5% to 20%.

[0046] Indeed, the compound having amino functional groups of this list and/or a content in these ranges are adapted to the cooling zone 13 because the amino functional group may react with formaldehyde thereby reducing the amount of formaldehyde in the aerosol generated. [0047] The filter media 121 may comprise a compound having amino functional group chosen from glycinate, amino cellulose, polyethylene-imine, fatty alkyl diamine or a mixture thereof.

[0048] The total content by weight of solids of compound having amino functional group in the filter media 121 may be from 1 % to 40%, in particular from 4% to 30%, more particularly from 5% to 20%.

[0049] Indeed, the compound having amino functional groups of this list and/or a content in these ranges are adapted to the filter media 121 because the amino functional group may react with formaldehyde thereby reducing the amount of formaldehyde in the aerosol generated.

[0050] The aerosol-generating substrate 111 of the aerosol-generating article 1 has a pH from 4.9 to 7.0, in particular from 5.0 to 6.0 and comprises:

- an aerosol-generating agent,

- nicotine, a salt of nicotine or a mixture thereof.

[0051] The pH of the aerosol-generating substrate 111 is measured as follows:

- grinding the aerosol-generating substrate 111 to obtain particles below 1 mm,

- weighing 5.0 +/- 0.1 mg of grounded aerosol-generating substrate and mixing with 100.0 +/- 0.1 g of deionized water, the resistivity of the deionized water being below 18.2 Megohm/cm,

- stirring magnetically the sample in water during 15 min at a temperature of 20°C,

- measuring the pH.

[0052] For the purposes of the present application, the term “fibrous support” denotes a base web made of fibers, in particular refined fibers. The base web is typically obtained by a papermaking process.

[0053] Forthe purposes of the present application, the term “cellulosic fibers” denotes fibers obtained by means of a chemical or mechanical or thermomechanical pulping process, such as wood pulp or annual plants fibers such as flax fibers and hemp fibers, in particular wood pulp. A mixture of these cellulosic fibers may also be used. Refined cellulosic fibers may also be used.

[0054] The cellulosic fibers may increase the mechanical strength properties of the aerosolgenerating substrate 111.

[0055] Wood pulp may be hardwood pulp, bleached hardwood pulp, softwood pulp, bleached softwood pulp, softwood fluff pulp, lyocell fibers (cellulose fibers which are ground and dissolved in N-methylmorpholine N-oxide monohydrate for the purpose of obtaining fibers with a cross section of variable shape (round, oval, cross-shaped, circular, lamellar cross section) with calibrated length and mass per unit length, which the person skilled in the art can choose depending on their needs), viscose fibers (fibers obtained by dissolving cellulose by means of modification of its hydroxyl groups by carbon disulfide (CS2) and then precipitating it in the presence of sulfuric acid (H2SO4) for the purpose of obtaining fibers with a cross section of variable shape (round, oval, cross-shaped, circular, lamellar cross section) with calibrated length and mass per unit length, which the person skilled in the art can choose depending on their needs) or a mixture thereof, in particular bleached softwood pulp, softwood pulp, softwood fluff pulp, lyocell fibers, viscose fibers or a mixture thereof, more particularly softwood pulp, hardwood pulp or a mixture thereof.

[0056] For the purposes of the present application, the term “plant fibers” denotes fibers obtained from one or more plants by means of a dissociation process. In such a process, one or more plant parts are mixed with a solvent in order to extract the solvent soluble compounds of the plant. The solvent soluble compound of the plant are then separated from the plant fibres to isolate and obtain, on the one hand, the plant fibres and, on the other hand, the solvent soluble compounds of the plant. A mixture of plant fibers may also be used. Refined plant fibers may also be used.

[0057] For the purposes of the present application, the terms “refined cellulosic fibers” and “refined plant fibers” denotes, respectively, cellulosic fibers and plant fibers which have undergone a refining step enabling fibrillation and/or cutting of the fibers. The refining step is conventionally carried out in a papermaking process, such as the papermaking process producing reconstituted papermaking tobacco.

[0058] The fibers of the fibrous support may consist of cellulosic fibers.

[0059] The fibers of the fibrous support may consist of plant fibers.

[0060] The fibers of the fibrous support may be a mixture of cellulosic fibers and plant fibers. In such fibrous support, the total content by weight of solids of the plant fibers included in the aerosolgenerating substrate 111 may be from 1 to 99%, in particular from 50% to 95%, more particularly from 80% to 92% by weight of solids of the aerosol-generating substrate 111 , the remaining fibers of the aerosol-generating substrate 111 being the cellulosic fibers.

[0061] For the purposes of the present application, the term “aerosol-generating agent” denotes a compound which allows the formation of an aerosol when it is heated.

[0062] The aerosol-generating agent may be a polyol, a non-polyol or a mixture thereof. Typically, an aerosol generating agent that is a polyol may be glycerol, propylene glycol, sorbitol, triethylene glycol or a mixture thereof. An aerosol generating agent that is a non-polyol may be glyceryl diacetate, glyceryl triacetate, triethyl citrate, isopropyl myristate or a mixture thereof.

[0063] The aerosol-generating agent may preferably be glycerol, propylene glycol or a mixture of glycerol and propylene glycol, glycerol being preferred.

[0064] Let SAG be the total content by weight of solids of the aerosol-generating agent in the aerosolgenerating substrate 111. SAG may be from 6% to 70%, in particular from 10% to 65%, more particularly from 12% to 25%.

[0065] The volume of the aerosol generated from an aerosol-generating substrate having an SAG lower than the ranges mentioned above is too low to be pleasant. This aerosol is also not tasteful.

[0066] For the purposes of the present application, “salt of nicotine” denotes a form of nicotine characterized by the interaction between nicotine in monoprotonated form or diprotonated form and an organic acid in carboxylate form. [0067] In the aerosol-generating substrate 111 , the salt of nicotine may be formed in-situ or ex -situ by the reaction between the nicotine and an organic acid. The skilled person knows that this reaction is an equilibrium. Therefore, nicotine and organic acid may be present with the salt of nicotine formed in-situ or ex-situ.

[0068] Alternatively, the salt of nicotine may be purchased as such and added to the aerosolgenerating substrate 111.

[0069] The total content by weight of solids of nicotine thereof in the aerosol-generating substrate 111 may be from 0.1 % to 8%, in particular from 0.5% to 4%, more particularly from 0.75% to 3%.

[0070] Advantageously, the aerosol-generating substrate 111 comprising nicotine thereof in such ranges generates an aerosol which enables the user of the aerosol-generating article 1 to get a nicotine experience similar to the experience provided by the aerosol generated by a combusted tobacco product.

[0071] The pH of the aerosol-generating substrate 111 may be obtained thanks to the compound having amino functional group, in particular the compound having amino functional group being an amino acid. Nevertheless, the compound having amino functional group, in particular the compound having amino functional group being an amino acid, may not be sufficient to reach the pH of the aerosol-generating substrate 111.

[0072] The aerosol-generating substrate 111 may thus comprise an organic acid.

Advantageously, the pH of the aerosol-generating substrate 111 from 4.9 to 7.0, in particular from 5.0 to 6.0 may be obtained thanks to this organic acid.

Moreover, the monoprotonated form of nicotine present in the aerosol-generating substrate 111 may result from the formation of a salt of nicotine by a reaction between the nicotine and the organic acid.

[0073] The organic acid may be alginic acid, benzoic acid, citric acid, fumaric acid, glycolic acid, lactic acid, levulinic acid, malic acid, pectic acid, pyruvic acid, salicylic acid, tartaric acid, glucuronic acid, galacturonic acid, myristic acid or a mixture thereof, in particular benzoic acid, citric acid, fumaric acid, glycolic acid, lactic acid, levulinic acid, malic acid, pyruvic acid, salicylic acid or a mixture thereof, more particularly benzoic acid, citric acid, malic acid, lactic acid, levulinic acid, salicylic acid or a mixture thereof.

[0074] Advantageously, the organic acids of this list:

- are mostly natural based products, thereby improving the naturality of the aerosolgenerating substrate 111 ,

- favor the formation of the salt of nicotine in the aerosol-generating substrate 111 with a low quantity of organic acid,

- limit the transfer of the organic acid in the aerosol generated by the aerosol-generating substrate 111 thereby limiting the acidic taste of said aerosol, and

- limit the loss of acid during the manufacture of the aerosol-generating article 1. [0075] The molar ratio of nicotine:organic acid may be from 1 :0.1 to 1 :10, in particular from 1 :0.4 to 1 :5, more particularly from 1 :0.5 to 1 :3. Advantageously, the aerosol-generating substrate 111 comprising the molar ratio in such ranges may have a pH in the above-mentioned ranges.

[0076] The aerosol-generating substrate 111 may comprise a plant extract.

[0077] For the purposes of the present application, the term “plant extract” denotes all of the solventsoluble compounds of the plant. An aerosol is generated during heating of the aerosol-generating substrate 111. Advantageously, the plant extract comprises compounds giving organoleptic properties and/or well-being properties to the aerosol. If the plant is a medicinal plant, then the plant extract gives therapeutic properties to the aerosol. Moreover, the organoleptic properties can be easily modified by simply changing the plant extract added to the aerosol-generating substrate 111.

[0078] Typically, the solvent may be an apolar solvent, an aprotic polar solvent, a protic polar solvent or a mixture thereof, in particular the solvent may be methanol, dichloromethane, ethanol, acetone, butanol, supercritical CO2, water or a mixture thereof, more particularly the solvent is ethanol, acetone, water or a mixture thereof, more particularly, the solvent is water.

[0079] The organic acid of aerosol-generating substrate 111 may be a compound of the plant extract added to the aerosol-generating substrate 111.

[0080] Indeed, the inventors noticed that a plant extract may confer to the aerosol-generating substrate 111 a pH from 4.9 to 7.0, in particular from 5.0 to 6.0 thanks to the organic acid present in said plant extract. Accordingly, said plant extract increases the naturalness of the aerosol-generating substrate 111.

[0081] In case the plant extract does not confer to the aerosol-generating substrate 111 a pH from 4.9 to 7.0, in particular from 5.0 to 6.0, the organic acid is thus added to the aerosol-generating substrate 111 to confer to said aerosol-generating substrate 111 a pH from 4.9 to 7.0, in particular from 5.0 to 6.0. This is especially true if no organic acid or an insufficient content of organic acid is present in the plant extract.

[0082] Without wishing to be bound by any theory, to determine if the plant extract confers to the aerosol-generating substrate 111 a pH from 4.9 to 7.0, in particular from 5.0 to 6.0, the skilled person can typically measure the pH of an aerosol-generating substrate comprising a plant extract devoid of an added organic acid.

In one embodiment, the pH of said aerosol-generating substrate is from 4.9 to 7.0, in particular from 5.0 to 6.0 without added organic acid, the plant extract thus confers the right pH range to the aerosolgenerating substrate 111.

In another embodiment, the pH of said aerosol-generating substrate being not from 4.9 to 7.0, in particular not from 5.0 to 6.0, an organic acid must be added during the process to produce to aerosol-generating substrate 111.

[0083] Coffee, ginkgo biloba, star anise, licorice, angelica, sweet flag, caper, turmeric, Chinese mahogany, rose hip, tsao-ko or a mixture thereof, in particular coffee, ginkgo biloba, star anise, licorice or a mixture thereof, more particularly ginkgo biloba, star anise or a mixture thereof are an example of plant whose extract may confer to the aerosol-generating substrate 111 a pH from 4.9 to 7.0, in particular from 5.0 to 6.0 without the addition of an organic acid to said aerosol-generating substrate 111.

[0084] The organoleptic properties and the therapeutic properties of the aerosol formed by heating the aerosol-generating substrate 111 may depend on the total content by weight of solids of the plant extract included in said aerosol-generating substrate 111.

[0085] The total content by weight of solids of the plant extract depends on the plant used and, more particularly, on the content of aromatic compounds or of compounds having therapeutic or well-being properties of the plant used.

[0086] Let Sp be the total content by weight of solids of the plant extract included in the aerosolgenerating substrate 111. Sp may be from 1 % to 60%, in particular from 5% to 50%, more particularly from 10% to 35%.

[0087] Advantageously, an Sp within these ranges of values makes it possible to generate, at a comfortable draw resistance, an aerosol having satisfactory organoleptic properties, i.e. having constant and high taste intensity and constant and higher volume.

[0088] Sp may be calculated thanks to the following formula: - , , , . . 100 - % of other additives, wherein initial powder weight is the weight of the aerosol-generating substrate 111 to be analyzed grounded in order to have a particle size of less than or equal to 1 mm, solid residue weight is the weight of the solid residue obtained by:

- mixing the grounded aerosol-generating substrate 111 with boiling water for 45 minutes in order to extract all soluble part of the aerosol-generating substrate 111 ,

- filtering the water with soluble part to obtain a residue, and

- drying the residue in oven at 100°C during 16h to obtain the solid residue, and

% of other additives is the sum of the total content by weight of solids of each other additive of the aerosol-generating substrate 111 , the other additive being nicotine, aerosol-generating agent, a compound having amino functional group, organic acid or a mixture thereof.

[0089] The plant fibers and the plant extract can be independently obtained from a plant chosen from spore-producing plants, seed-producing plants or a mixture thereof. In particular, the plant may be a plant chosen from food plants, aromatic plants, fragrant plants, medicinal plants, plants of the Cannabaceae family or a mixture thereof.

[0090] If the plant is a medicinal plant, the aerosol generated by heating the aerosol-generating substrate 111 may also have therapeutic properties so that the aerosol-generating article 1 can be used for a therapeutic treatment.

[0091] Advantageously, a plant extract obtained from a plant mixture makes it possible to offer a broad panel of organoleptic properties and/or therapeutic properties. A plant mixture also makes it possible to counteract the unpleasant organoleptic properties of a plant of the mixture, for example a medicinal plant, with the pleasant organoleptic properties of another plant of the mixture, for example an aromatic plant or a fragrant plant.

[0092] The plant fibers can be obtained from a first plant and the plant extract can be obtained from a second plant. Indeed, this is because the fibers of a plant may not have mechanical properties which allow the formation of a fibrous support, but the extract of this plant may confer desired organoleptic properties and/or therapeutic properties in the aerosol. Conversely, the fibers of a plant may have mechanical properties which allow the formation of a fibrous support, but the extract of this plant may not confer desired organoleptic properties and/or therapeutic properties in the aerosol.

[0093] Advantageously, mixing plants to obtain the plant fibers makes it possible to adjust the mechanical properties of the aerosol-generating substrate 111 and/or the organoleptic or chemical properties of the aerosol.

[0094] Typically, the food plants can be garlic, cardamom, coffee, ginger, lemon verbena, licorice, papaya, stevia, tea, cacao tree, chamomile, mate, rooibos, anise such as star anise (or badian) and green anise, or a mixture thereof, fennel, citronella, angelica, caper, turmeric, Chinese mahogany and tsao-ko.

[0095] Typically, the aromatic plants can be basil, turmeric, clove, laurel, oregano, mint, rosemary, sage, thyme, or a mixture thereof.

[0096] Typically, the fragrant plants can be lavender, marigolds, rose, eucalyptus, sweet flag or a mixture thereof.

[0097] Typically, the medicinal plants are those indicated in the document, list A of traditionally used medicinal plants (French pharmacopeia January 2016, published by the Agence Nationale de Securite du Medicament (ANSM) [French National Agency for Drug and Health Product Safety] or plants known to comprise compounds which have therapeutic properties. Typically, the medicinal plants listed can be ginkgo biloba, ginseng, sour cherry, peppermint, sweet mint, willow, red vine or a mixture thereof.

[0098] Typically, eucalyptus is among the medicinal plants known to comprise compounds which have therapeutic properties.

[0099] Typically, the plant fibers and the plant extract of the aerosol-generating substrate 111 may be derived from various plant parts, the plant parts being parts of the plant itself or the result of the processing of various plant parts. Typically, the plant parts may be whole parts of the plant or debris originating from threshing or mixing and shredding the plant parts. The plant parts may also be byproducts of extraction.

[0100] Typically, the plant parts may be selected from the plant parts richest in aromatic compounds conferring its organoleptic properties to the aerosol. Typically, these parts may be the whole plant, the aerial plant parts, such as the flower bud, the branch bark, the stem bark, the leaves, the flower, the fruit and its peduncle, the seed, the petal, the flower head, or the underground parts, for example the bulb, the roots, the root bark, the rhizome or a mixture thereof. The plant part may also be the result of the mechanical, chemical or mechanical-chemical processing of one or more plant parts, such as for example the shell protecting the cacao bean resulting from the bean dehulling process.

[0101] Among the food plants, the angelica fruit, the angelica bud, the angelica root, the caper bud, the tumeric root, the turmeric stem, the Chinese mahogany bud, the tsao-ko fruit, the garlic bulb, the coffee cherry, the star anise fruit, the rhizome of ginger, the licorice root, the needle, leaf and stem of rooibos, and the leaves of stevia, papaya or tea may for example be selected as parts.

[0102] Among the aromatic plants, clove flower buds (the cloves), basil, laurel and sage leaves, mint, oregano, rosemary and thyme leaves and flower head, or the turmeric rhizome may for example be selected as parts.

[0103] Typically, among the fragrant plants, the lavender flower and flower head, the sweet flag rhizome, rose hip or the rose flower bud and petals may be selected.

[0104] Among the medicinal plants listed in the French pharmacopeia, gingko leaf, the underground part of ginseng, the peduncle of the sour cherry fruit (cherry stalk), the leaves and flower head of peppermint, the stem bark and the leaves of willow, or the leaves of red vine may be selected for example.

[0105] The plant may be tobacco, rooibos, eucalyptus, angelica, anise such as star anise, green anise or a mixture thereof, hemp, cardamom, cocoa, cannabis, hop, dill, raspberry, bay laurel, nettle, pin, tendu, grape, fennel, lemongrass, lemon verbena, peppermint, spearmint, chamomile, flax, ginger, ginkgo biloba, hazel, hibiscus, laurel, licorice, marigolds, matcha, star anis, yerba mate, mate, orange skin, papaya, rose, sage, tea such as green tea or black tea, thyme, clove, cinnamon, coffee, basil, bay leaves, cardamom, coriander, cumin, nutmeg, oregano, paprika, rosemary, saffron, lavender, lemon peel, mint, juniper, elderflower, vanilla, Wintergreen, beefsteak plant, sorrel, curcuma, sandalwood, cilantro, bergamot, orange blossom, myrtle, cassis, valerian, pimento, mace, damien, marjoram, olive, lemon balm, lemon basil, chive, carvi, verbena, tarragon, geranium, mulberry, ginseng, theanine, theacrine, maca, ashwagandha, damiana, guarana, chlorophyll, baobab, stevia or a mixture thereof, in particular rooibos, anise such as star anise, green anise or a mixture thereof, yerba mate, cocoa, lemon balm, myrtle, lavender, hazel, cardamom, cinnamon, eucalyptus, fennel, ginger, ginkgo biloba, mint, peppermint, laurel, lemon verbena, licorice, marigolds, papaya, rosemary, sage, sorrel, stevia, tea such as green tea or black tea or a mixture thereof, more particularly rooibos, star anis, yerba mate, ginkgo biloba, mint, laurel, eucalyptus, cocoa, lemon balm, lemon verbena, myrtle, lavender, hazel, green anise, sage, tea such as green tea or black tea or a mixture thereof.

[0106] The plant may be star anis, yerba mate, ginkgo biloba, mint, laurel, eucalyptus, cocoa, lemon balm, lemon verbena, myrtle, lavender, hazel, green anise, sage, tea such as green tea or black tea or a mixture thereof.

[0107] The plant may be rooibos. [0108] Typically, the aerosol-generating substrate 111 may have a basis weight of lower than 300 g/m², in particular from 15 g/m² to 200 g/m², more particularly from 30 g/m² to 150 g/m².

[0109] To determine the basis weight of the aerosol-generating substrate 111 , the following method may be used: a sample of 0.25 m² is cut out with a template (dimensions: 57.5 x 43.5 cm) at approximately 15 cm from the edge of the aerosol-generating substrate 111 to be analyzed. The sample is then folded in four and placed on a hotplate so as to be dried thereon in order to remove the water without removing the aerosol-generating agent.

The dried sample is then weighed to determine the basis weight of the aerosol-generating substrate 111.

[0110] The cooling zone 13 of the aerosol-generating article 1 is defined by an inner wall of a paper tube 131.

[0111] The paper tube 131 of the cooling zone 13 may be any kind of paper adapted to wrap a portion of, in particular all the aerosol-generating substrate 111 and a portion of, in particular all the filter media 121 to produce the aerosol-generating article 1 . The paper tube 131 may increase the stiffness of the aerosol-generating article 1.

[0112] The paper tube 131 may have a basis weight of from 60 g/m² to 180 g/m², in particular from 80 g/m² to 150 g/m², more particularly from 100 g/m² to 120 g/m².

[0113] Advantageously, a basis weight within these ranges makes it possible to obtain the cooling zone 13 easily and with satisfactory mechanical properties, in particular stiffness.

[0114] Moreover, the mechanical properties of the paper tube 131 are not deteriorated when the compound having amino functional group is added to the paper tube 131 .

[0115] The paper tube 131 may comprise cellulosic fibers, plant fibers or a mixture thereof.

[0116] The cellulosic fibers and the plant fibers of the paper tube 131 are as defined above in relation with the aerosol-generating substrate 111.

[0117] The paper tube 131 may be empty or comprise an aerosol property modifying element. Accordingly, the compound having amino functional group may be at the inner wall of the paper tube 131 , in the aerosol property modifying element or a combination thereof.

[0118] The paper tube 131 , in particular the paper tube 131 being empty, may comprise perforations. Typically, the perforations can be formed by a laser, mechanical perforation or electro perforation. Advantageously, these perforations can help to cool down the aerosol more efficiently.

[0119] The aerosol property modifying element can be a hollow filter media, a cooler element such as a silicon cooler element, cooling stones or polyesters cooler, a flavors capsule, an enrolled paper, a crepe paper to restrict the aerosol flow or to support the flavor capsule or a combination thereof. A combination of a silicon cooler element and cooling stones, a combination of a paper roll and an aroma capsule and a combination of crepe paper supporting the flavor capsule, a combination of a polyester nonwoven or creped film such as polylactic acid are examples of combination of aerosol property modifying elements that can be comprised in the paper tube 131.

[0120] The aerosol-filtering zone 12 of the aerosol-generating article 1 comprises a filter media 121.

[0121] The filter media 121 of the aerosol-filtering zone 12 may be any kind of filter adapted to filter an aerosol generated by the aerosol-generating substrate 111 of the aerosol-generating article 1.

[0122] For example, the filter media 121 may have a right circular cylindrical shape and may comprise an outer envelope of plug wrap paper and a substrate located within the outer envelope.

[0123] The substrate of the filter media 121 may be a cellulose acetate substrate, a paper substrate, a nonwoven substrate or a combination thereof.

[0124] Advantageously, an aerosol-generating article 1 comprising a filter media 121 comprising a paper substrate or a nonwoven substrate complies with the Directive (EU) 2019/904 of the European Parliament and of the Council of 5 June 2019 on the reduction of the impact of certain plastic products on the environment.

[0125] For the purposes of the present application, "cellulose acetate substrate" denotes a tow of cellulose acetate fibers obtained by a process well known by the skilled person.

[0126] For the purposes of the present application, "paper substrate" denotes a sheet consisting of cellulosic fibers obtained by a wetlaid process.

[0127] For the purposes of the present application, "nonwoven substrate" denotes a manufactured sheet consisting of a web or ply of directionally or randomly oriented cellulosic fibers bonded together by a binder. The airlaid process and the drylaid process are particularly suitable to produce the nonwoven substrate. Thus, the nonwoven substrate of the filter media 121 can be obtained by an airlaid process or a drylaid process.

[0128] The cellulosic fibers of the paper substrate and of the nonwoven substrate can be hardwood pulp, bleached hardwood pulp, softwood pulp, bleached softwood pulp, softwood fluff pulp, hemp fibre, Indian hemp fibre, jute fibre, kenaf fibre, kudzu fibre, coin vine fibre, flax fibre, okra fibre, nettle fibre, papyrus fibre, ramie fibre, sisal fibre, esparto fibre, cotton fiber, kapok fiber, luffa fiber, milkweed fiber, lyocell fibres (cellulose fibres which are ground and dissolved in N-methylmorpholine N-oxide monohydrate for the purpose of obtaining fibres with a cross section of variable shape (round, oval, cross-shaped, circular, lamellar cross section) with calibrated length and mass per unit length, which the person skilled in the art can choose depending on their needs), viscose fibres (fibres obtained by dissolving cellulose by means of modification of its hydroxyl groups by carbon disulfide (CS2) and then precipitating it in the presence of sulfuric acid (H2SO4) for the purpose of obtaining fibres with a cross section of variable shape (round, oval, cross-shaped, circular, lamellar cross section) with calibrated length and mass per unit length, which the person skilled in the art can choose depending on their needs) or a mixture thereof, in particular hardwood pulp, softwood pulp, softwood fluff pulp or a mixture, more particularly softwood pulp or softwood fluff pulp.

[0129] For the purposes of the present application, "binder" denotes a compound having properties enabling consolidation of the nonwoven substrate. [0130] For example, the binder can be a natural polymer, a synthetic polymer or copolymer or a mixture thereof. Advantageously, the natural polymer improves the naturality of the aerosolgenerating article 1 of the present invention.

[0131] The natural polymer can be a polysaccharide, a cellulose derivative, or a mixture thereof.

The polysaccharide which can be used as binder can be a polysaccharide or a polysaccharide derivative. For example, starch, dextrin, arabic gum or a mixture thereof can be used as binder, in particular starch.

For example, the cellulose derivative can be ethyl cellulose, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, an alkali metal salt of carboxymethyl cellulose, or a mixture thereof, in particular carboxymethyl cellulose.

As alkali metal of the carboxymethyl cellulose salt, mention may be made of potassium, sodium, and magnesium.

The synthetic polymer or copolymer can, for example, be a latex, a polyvinyl alcohol, an ethylenevinyl alcohol, a polyvinyl acetate, a polyvinyl chloride, a styrene-butadiene, a polybutadiene, polyacrylics, an ethylene-vinyl acetate, or a mixture thereof, in particular ethyl-vinyl alcohol, polyvinyl acetate, polyvinyl alcohol or a mixture thereof.

[0132] The nonwoven substrate comprises cellulosic fibers and a binder, the cellulosic fibers may represent from 70% to 99%, in particular from 80% to 98%, more particularly from 85% to 98% by weight of solids of said nonwoven substrate, the binder may represent from 1 % to 30%, in particular from 2% to 20%, more particularly from 2% to 15% by weight of solids of said nonwoven substrate.

[0133] The nonwoven substrate may have a density of from 7 mg/cm³ to 60 mg/cm³, in particular from 8 mg/cm³ to 50 mg/cm³, more particularly from 10 mg/cm³ to 45 mg/cm³.

[0134] Typically, the density of the nonwoven substrate is calculated by dividing its basis weight by its thickness.

[0135] The basis weight of the nonwoven substrate may be from 20 g/m² to 75 g/m², in particular from 23 g/m² to 70 g/m², more particularly from 25 g/m² to 60 g/m².

[0136] The thickness of the nonwoven substrate may be from 700 pm to 6000 pm, in particular from 800 pm to 4700 pm, more particularly from 900 pm to 4500 pm.

[0137] The basis weight of the paper substrate can be from 10 g/m² to 60 g/m², in particular from 15 g/m² to 55 g/m², more particularly from 20 g/m² to 50 g/m².

These basis weight ranges are those of conventional paper substrates. Thus, the person skilled in the art will know how to easily obtain the paper substrate having such a basis weight.

Moreover, these basis weight ranges make it possible to easily adapt the paper substrate to different filter medias 12.

[0138] The standard ISO 536:2012 can be used to determine the basis weight of the paper substrate and of the nonwoven substrate. The substrate is conditioned for at least 16 hours at 23°C and 50% relative humidity before the measurement. [0139] To measure the thickness of the nonwoven substrate, it is possible to use a dead-weight micrometer comprising a 25 cm² measuring head with two planar, parallel and circular pressure surfaces. During the measurement, the nonwoven substrate is placed between the two pressure surfaces for 10 seconds. The pressure exerted between the pressure surfaces during the measurement of the thickness is 0.5 kPa. The substrate is conditioned for at least 16 hours at 23°C and 50% relative humidity before the measurement.

[0140] The paper substrate and the non-woven substrate can be shaped, in particular it can be crimped, folded or rolled up. This shaping can make it possible to modify the properties of the paper substrate and therefore the properties of the filter media 121 comprising it. For example, crimping can make it possible to modify the density of the paper substrate and thus to increase or reduce the pressure drop of the filter media 121 comprising the paper substrate without changing the weight of the filter media 121. In this way, the shaping of the paper substrate by known processes such as crimping renders it easily adaptable to different filters.

[0141] Alternatively, the nonwoven substrate may not be crimped before the formation of the filter media 121. This is advantageous since it makes it possible to produce a filter media 121 while simplifying the production of the filter media 121 .

[0142] It is proposed a method for producing the aerosol-generating article 1 as defined above comprising the following steps: a) producing the aerosol-generating substrate 111 , b) producing the filter media 121 , and c) forming the cooling zone 13 between the aerosol-generating zone 11 and the aerosolfiltering zone 12 by: wrapping a wrap paper around a portion of, in particular all the aerosol-generating substrate 111 and a portion of, in particular all the filter media 121 thereby obtaining the aerosolgenerating article 1 , wherein the wrap paper at the cooling zone 13 forms the paper tube 131 , or placing a paper tube 131 between the aerosol-generating substrate 111 and the filter media 121 , then wrapping a wrap paper around a portion of, in particular all the aerosolgenerating substrate 111 , the paper tube 131 and a portion of, in particular all the filter media 121 thereby obtaining the aerosol-generating article 1 , characterized in that the aerosol-generating substrate 111 produced during step a), the filter media 121 produced during step b), the cooling zone 13 formed during step c) or a combination thereof comprises the compound having amino functional group.

[0143] Advantageously, this method can be easily implemented. In particular step c) and d) is a common step for the skilled person. Therefore, the aerosol-generating article 1 can be easily manufactured and thus its manufacturing cost can be easily optimized.

[0144] The aerosol-generating substrate 111 , the filter media 121 , the cooling zone 13 and the compound having amino functional group are as defined above in relation with the aerosolgenerating article 1. [0145] The wrap paper involved in step c) is as the paper of the paper tube 131 defined above in relation with the aerosol-generating article 1.

[0146] During step c), the wrap paper may be wrapped around an aerosol property modifying element placed between the aerosol-generating substrate 111 and the filter media 121 or the paper tube 131 may comprise an aerosol property modifying element so that the cooling zone 13 comprised said aerosol property modifying element.

[0147] The aerosol property modifying element is as defined above in relation with the aerosolgenerating article 1.

[0148] The compound having amino functional group may be added before or after step c), in particular before step c): to the surface of the paper wrapped during step c) corresponding to the cooling zone 13, to the aerosol property modifying element comprised in the cooling zone 13, or to a combination thereof.

[0149] The compound having amino functional group may be impregnated or sprayed to the paper wrapped during step c).

[0150] The compound having amino functional group may be impregnated or sprayed to the aerosol property modifying element.

[0151] Step a) may comprise the following sub-steps: a1) forming a solution comprising:

- the aerosol-generating agent, and

- the nicotine, the salt of nicotine or a mixture thereof, a2) bringing the solution into contact with a base web produced from cellulosic fibers, plant fibers or a mixture thereof to obtain a wet fibrous support, and a3) drying the wet fibrous support to produce the aerosol-generating substrate 111.

[0152] The cellulosic fibers, the plant fibers, the aerosol-generating agent, the nicotine and the salt of nicotine are as defined above in relation with the aerosol-generating article 1.

[0153] The base web may be produced by passing the cellulosic fibers, plant fibers or a mixture thereof through a papermaking machine. Therefore, the aerosol-generating substrate 111 may be obtainable by a papermaking process.

[0154] The aerosol-generating substrate 111 produced by step a) may comprise the compound having amino functional group. The solution formed during sub-step a1) and involved into sub-step a2) may thus comprise the compound having amino functional group.

[0155] The solution formed during sub-step a1) and involved in sub-step a2) may comprise an organic acid as defined above in relation with the aerosol-generating article 1.

[0156] The aerosol-generating substrate 111 produced by step a) may further comprise a plant extract as defined above in relation with the aerosol-generating article. So the solution formed during sub-step a1) and involved in sub-step a2) may comprise a plant extract as defined above in relation with the aerosol-generating article 1.

[0157] In the solution formed during sub-step a1) and involved in sub-step a2), the molar ratio of nicotine:organic acid may be from 1 :0.1 to 1 :10, in particular from 1 :0.4 to 1 :5, more particularly from 1 :0.5 to 1 :3.

[0158] The pH of the solution formed during sub-step a1) and involved in sub-step a2) may be acidic, in particular from 3.5 to 6.0, more particularly from 4.3. to 5.2.

Advantageously, a solution having a pH in these ranges may enable the production of the aerosolgenerating substrate 111.

[0159] The pH of the solution mainly depends on the amount of compound having amino functional group, organic acid, plant extract, nicotine and/or salt of nicotine in said solution. The skilled person knows how to adjust the amount of compound having amino functional group, organic acid, nicotine and/or salt of nicotine in the solution so that said solution has a pH in the above range.

[0160] The inventors noticed that the pH and the buffer power of the base web may depend on the type of fibers. The pH of the solution may thus be adapted to the pH and the buffer power of the base web to enable the production of the aerosol-generating substrate 111.

[0161] The pH of the solution is determined using a pH electrode. The pH of the base web is determined by the method described above determining the pH of the aerosol-generating substrate 111.

[0162] Sub-step a1 is a step well known to the skilled person. The skilled person knows how to adapt the parameters of this sub-step to produce the solution.

[0163] In particular, the skilled person will know how to form a mixture comprising a salt of nicotine by mixing nicotine with the organic acid, an amino acid as compound having amino functional group or a mixture thereof.

[0164] For example, during the sub-step a1),

- the amino acid as compound having amino functional group may be mixed with the nicotine and the aerosol-generating agent to form a first mixture,

- the plant extract preheated between 40°C and 60°C may then be added to this first mixture to form the solution, and

- a solvent, in particular water, may be added to the solution and/or the solution may be heated, if necessary, between 40°C and 60°C.

[0165] The salt of nicotine is formed in-situ in the first mixture by reaction between the nicotine and the amino acid.

[0166] Adding a solvent, in particular water, to the solution and heating the solution between 40°C and 60°C favorizes the solubilization of the components in the solution

[0167] Preheating the plant extract between 40°C and 60°C before the addition to the first mixture favors advantageously the solubilization of the plant extract in the second mixture. [0168] The plant fibers and the plant extract involved in sub-step a1) may be obtained in accordance with the following steps: d) mixing one or more plant parts with a solvent in order to extract the plant extract from the plant fibers, and e) separating the plant extract from the plant fibers.

[0169] The plant extract and the plant fibers are therefore typically obtained by means of a dissociation process. During step d), one or more plant parts are mixed with a solvent, for example in a digester, in order to extract the plant extract from the plant fibers. During step e), the plant extract is separated from the plant fibers, for example by passing through a screw press, in order to isolate and obtain, on the one hand, the plant fibers and, on the other hand, the plant extract.

[0170] Typically, the solvent may be an apolar solvent, an aprotic polar solvent, a protic polar solvent, or a mixture thereof, in particular the solvent may be methanol, dichloromethane, ethanol, acetone, butanol, supercritical CO2, water or a mixture thereof, more particularly the solvent is ethanol, acetone, water or a mixture thereof.

[0171] The solvent may be an aqueous solvent, most particularly the solvent is water.

[0172] The skilled person knows how to adapt the temperature of the solvent during step d) to the plant, to the plant part and to the plant parts to be treated. Typically, the temperature of the solvent during the treatment of a root or of a bark will be higher than the temperature of the solvent during the treatment of a leaf or a petal.

[0173] Typically, the temperature of the solvent during step d) may be from 10°C to 100°C, in particular from 30°C to 90°C, more particularly from 40°C to 80°C.

[0174] Typically, the plant fibers may be refined in a refiner to produce the base web.

[0175] Typically, the plant fibers may originate from various plants.

[0176] The fibers of each plant can be obtained separately according to the dissociation process described above. They can subsequently be mixed such that this mixture of fibers from various plants passes through the papermaking machine so as to constitute the fibrous support. It is also possible to obtain fibers from various plants together by bringing together one or more parts of the various plants and then subjecting them to the dissociation process described above. The temperature of the water will then be adapted to the plants to be treated and, in particular, to the plant requiring the highest temperature of the water for extracting the extract of this plant. This alternative embodiment is very advantageous since it makes it possible to obtain the fibers of the various plants without carrying out several dissociation processes in parallel.

[0177] Typically, the plant extract may be an extract of various plants.

[0178] The extract of various plants can be obtained by mixing various plant extracts obtained separately according to the dissociation process described above. It is also possible to obtain the extract of various plants by bringing together one or more parts of the various plants and then subjecting them to the dissociation process described above. The temperature of the water will then be adapted to the plants to be treated and, in particular, to the plant requiring the highest temperature of the water for extracting the extract of this water-soluble plant. This alternative embodiment is very advantageous since it makes it possible to obtain the extract of various plants without carrying out several processes in parallel. In these two situations, the extracts of various plants are involved in sub-step a1).

[0179] Typically, the plant extract can be concentrated before being added to the solution during sub-step a1). An equipment such as a vacuum evaporation device can be used to concentrate the plant extract.

[0180] Typically, sub-step a2) can be carried out by impregnation or by spraying, in particular by impregnation. Typically, the impregnation can be carried out by means of a size press.

[0181] Typically, the drying sub-step a3) can be carried out by infrared ramp, American battery drying drums, hot-air drying in a tunnel drier, a vertical drier, a fluidized-bed drier, a pneumatic drier, in particular in a tunnel drier.

[0182] The aerosol-generating substrate 1 11 produced at sub-step a3) may be shaped in particulate form, in the form of crimped sheet, in shredded form.

[0183] Step b) may comprise the following sub-steps: b11) forming a nonwoven substrate by a drylaid process or an airlaid process, b12) forming a rod of nonwoven substrate from the nonwoven substrate, b13) wrapping the rod of nonwoven substrate with a sheet of plug wrap paper, b14) depositing an adhesive line, joining the sheet of plug wrap paper to obtain a rod of filtering material, b15) cutting the rod of filtering material to produce the filter media 121.

[0184] Sub-step b1 1) may comprise the following sub-steps: i) producing a web from cellulosic fibers by a drylaid process or an airlaid process, and ii) consolidating the web chemically thanks to a binder or mechanically, iii) drying, if necessary, the web resulting from step ii) to obtain the nonwoven substrate.

[0185] The drylaid process and the airlaid process are two different conventional routes known to the person skilled in the art to produce a web. The person skilled in the art will know how to adapt the parameters of the drylaid process and the airlaid process to produce the nonwoven substrate.

[0186] During introduction step ii), an aqueous dispersion of the binder may be introduced into the web. This introduction may for example be carried out by impregnation, such as impregnation with a size press, by spraying, such as spraying using a spray, by surface application, such as surface application by coating or by printing, in particular by using a spray. Advantageously, the spraying will be performed on both faces of the web.

[0187] The aqueous dispersion of the binder can be obtained by any technique known to the person skilled in the art. The person skilled in the art will know how to adapt the concentration of binder in the aqueous dispersion to obtain the desired content of binder in the nonwoven substrate of the filter media 121 .

[0188] During step ii), the mechanical consolidation can be carried out thanks to needle or by hydroentaglement.

[0189] Drying step iii) can be carried out when step ii) is the chemical consolidation of the web chemically thanks to a binder.

[0190] Drying step iii) can, for example, be carried out by a drying device, such as a tunnel through which air passes, through air drying or an infrared ramp.

[0191] This drying step iii) can be carried out at a temperature of between 75°C and 200°C, in particular between 90°C and 170°C, more particularly between 100°C and 120°C. A temperature within these ranges advantageously makes it possible to minimize the duration of this drying step iii) while at the same time minimizing the deterioration of the cellulosic fibers of the nonwoven substrate, thus optimizing the method of the invention.

[0192] Advantageously, the combination of the introduction step ii) and of the drying step iii) makes it possible to improve the cohesion of the cellulosic fibers and hence to consolidate the structure of the nonwoven substrate of the filter media 121.

[0193] The cellulosic fibers used in production step i) can be a mixture of cellulosic fibers. This mixture of cellulosic fibers can be obtained before production step i).

[0194] The compound having amino functional group may be added to: the nonwoven substrate formed during sub-step b11) thereby obtaining a functionalized nonwoven substrate, said functionalized nonwoven substrate being involved in sub-step b12), the sheet of plug wrap paper thereby obtaining a functionalized sheet of plug wrap paper, said functionalized sheet of plug wrap paper being involved in sub-step b13), or a combination thereof.

[0195] The compound having amino functional group may be impregnated or sprayed to the nonwoven substrate,

[0196] The compound having amino functional group may be impregnated or sprayed to the sheet of plug wrap paper.

[0197] Step b) may alternatively comprise the following sub-steps: b21) forming a paper substrate by a wetlaid process, b22) forming a rod of paper substrate from the paper substrate, b23) wrapping the rod of paper substrate with a sheet of plug wrap paper, b24) depositing an adhesive line, joining the sheet of plug wrap paper to obtain a rod of filtering material, and b25) cutting the rod of filtering material to produce the filter media 121. [0198] The filter media 121 produced during sub-step b25) may have a right circular cylindrical shape and may comprise an outer envelope of plug wrap paper and a paper substrate located within the outer envelope.

[0199] The wetlaid process is a conventional process known to the skilled person. The skilled person knows how to adapt the parameters of this process to produce the base web during sub-step b21).

[0200] The paper substrate formed in sub-step b21) can be shaped.

[0201] Therefore, the process may comprise, between sub-step b21) and sub-step b22), a step of shaping the paper substrate by crimping, embossing, folding, compression or combination thereof to obtain a shaped paper substrate, said shaped paper substrate being involved into sub-step b22).

[0202] Shapping the paper substrate may be useful to modify the pressure drop of the filter media 121.

[0203] Sub-steps b23) to b25) are steps well known to the skilled person. The skilled person knows how to adapt the parameters of these sub-steps to produce the filter media 121 .

[0204] The compound having amino functional group may be added to: the paper substrate formed during sub-step b21) thereby obtaining a functionalized paper substrate, said functionalized paper substrate being involved in sub-step b22), the sheet of plug wrap paper thereby obtaining a functionalized sheet of plug wrap paper, said functionalized sheet of plug wrap paper being involved in sub-step b23), or a combination thereof.

[0205] The compound having amino functional group may be impregnated, coated or sprayed to the paper substrate.

[0206] The compound having amino functional group may be impregnated, coated or sprayed to the sheet of plug wrap paper.

[0207] It is also proposed the use of the aerosol-generating article 1 as defined above in an aerosol generating system.

[0208] For the purposes of the present application, the expression “aerosol generating system” denotes any device which allows the formation of an aerosol intended to be inhaled by a consumer. The aerosol provides nicotine to the consumer. Moreover, thanks to the aerosol generating system, the formation of harmful constituents during combustion is limited, thereby very significantly reducing the consumer's exposure to said harmful constituents.

[0209] Typically, an aerosol generating system comprises, in the direction of the air flow, an air inlet, a heating body, a lodging intended to put in place and hold the aerosol-generating article 1. The air inlet, the heating body and the lodging are typically connected at least fluidically to one another.

[0210] When the aerosol generating system is used, the aerosol-generating article 1 is introduced by the user in the lodging. The air is then sucked into the aerosol generating system via the air inlet by the user; the air sucked in then contact the heated body so as to obtain heated air, an aerosol is formed from the aerosol-generating article 1 thank to the heated air and is then inhaled by the user.

[0211] The aerosol generating system can be a device for heating tobacco without burning it (such as IQOS™ or gio™), an E-cigarette (such as Vuse), an herb vaporizer (such as Pax®), or an hybrid technology (such as Ploom™ Tech).

[0212] It is also proposed a non-therapeutic use of the aerosol-generating article 1 as defined above in an aerosol generating system.

[0213] It is also proposed the aerosol-generating article 1 defined above for use thereof in an aerosol generating system, the plant being chosen from medicinal plants.

[0214] The aerosol-generating substrate 111 of the aerosol-generating article 1 can generate an aerosol with a low amount of formaldehyde.

[0215] Therefore, it is proposed an aerosol-generating substrate 111 having a pH from 4.9 to 7.0, in particular from 5.0 to 6.0, and comprising:

- an aerosol-generating agent,

- nicotine, a salt of nicotine or a mixture thereof, and

- optionally a plant extract, an organic acid or a mixture thereof, characterized in that it further comprises a compound having amino functional group.

[0216] All the features and properties of the aerosol-generating substrate 111 described above in relation with the aerosol-generating article 1 apply to this aerosol-generating substrate 111.

[0217] Advantageously, this aerosol-generating substrate 111 generates an aerosol comprising a reduced amount of formaldehyde in comparison to an aerosol generated by an aerosol-generating substrate similar to this aerosol-generating substrate 111 but devoid of compound having amino functional group.

[0218] This aerosol-generating substrate 111 can be produced by the step a) of the method for producing the aerosol-generating article 1 described above.

[0219] Therefore, it is proposed a method for producing this aerosol-generating substrate 111 comprising the following steps: a’) forming a solution comprising:

- the aerosol-generating agent, and

- the nicotine, the salt of nicotine or a mixture thereof, a”) bringing the solution into contact with a base web produced from cellulosic fibers, plant fibers or a mixture thereof to obtain a wet fibrous support, and a’”) drying the wet fibrous support to produce the aerosol-generating substrate (111), characterized in that the solution formed during step a1) and involved into step a2) further comprises the compound having amino functional group. [0220] All the features and properties of the sub-steps a1), a2) and a3) described above in relation with the method for producing the aerosol-generating article 1 apply, respectively, to the steps a’), a”) and a’”) of this method.

[0221] The aerosol-filtering zone 12 of the aerosol-generating article 1 can reduce the amount of formaldehyde in an aerosol flowing through its filter media 121 .

[0222] Therefore, it is proposed a filter media 121 for an aerosol-generating article 1 , characterized in that it comprises a compound having amino functional group.

[0223] All the features and properties of the filter media 121 described above in relation with the aerosol-generating article 1 apply to this filter media 121 .

[0224] Advantageously, the aerosol filtered by this filter media 121 comprises less formaldehyde than an aerosol filtered by a filter media similar to this filter media 121 but devoid of compound having amino functional group.

[0225] The filter media 121 can be produced by the step b) of the method for producing the aerosolgenerating article 1 described above.

[0226] Therefore, it is proposed a method for producing this filter media 121 comprising the following steps: bT) forming a nonwoven substrate by a drylaid process or an airlaid process, b1 ”) forming a rod of nonwoven substrate from the nonwoven substrate, b1 ”’) wrapping the rod of nonwoven substrate with a sheet of plug wrap paper, b1 ””) depositing an adhesive line, joining the sheet of plug wrap paper to obtain a rod of filtering material, b1 ’””) cutting the rod of filtering material to produce the filter media (121), characterized in that the compound having amino functional group is added to: the nonwoven substrate formed during step bT) thereby obtaining a functionalized nonwoven substrate, said functionalized nonwoven substrate being involved in step b1 ”), the sheet of plug wrap paper thereby obtaining a functionalized sheet of plug wrap paper, said functionalized sheet of plug wrap paper being involved in step bT”), or a combination thereof.

[0227] All the features and properties of the sub-steps b1 1), b12), b13), b14) and b15) described above in relation with the method for producing the aerosol-generating article 1 apply, respectively, to the steps bT), b1 ”), bT”), b1 ””) and b1 ’””) of this method.

[0228] The compound having amino functional group may be impregnated or sprayed to the nonwoven substrate,

[0229] The compound having amino functional group may be impregnated, coated or sprayed to the sheet of plug wrap paper.

[0230] It is also proposed a method for producing this filter media 121 comprising the following steps: b2’) forming a paper substrate by a wetlaid process, b2”) forming a rod of paper substrate from the paper substrate, b2”’) wrapping the rod of paper substrate with a sheet of plug wrap paper, b2””) depositing an adhesive line, joining the sheet of plug wrap paper to obtain a rod of filtering material, and b2””’) cutting the rod of filtering material to produce the filter media 121 , characterized in that the compound having amino functional group is added to: the paper substrate formed during step b2’) thereby obtaining a functionalized paper substrate, said functionalized paper substrate being involved in step b2”), sheet of plug wrap paper thereby obtaining a functionalized sheet of plug wrap paper, said functionalized sheet of plug wrap paper being involved in step b2”’), or a combination thereof.

[0231] All the features and properties of the sub-steps b21), b22), b23), b24) and b25) described above in relation with the method for producing the aerosol-generating article 1 apply, respectively, to the steps b2’), b2”), b2”’), b2””) and b2””’) of this method.

[0232] The compound having amino functional group may be impregnated, coated or sprayed to the paper substrate.

[0233] The compound having amino functional group may be impregnated, coated or sprayed to the sheet of plug wrap paper.

[0234] The cooling zone 13 of the aerosol-generating article 1 can reduce the amount of formaldehyde in an aerosol flowing inside the paper tube 131.

[0235] Therefore, it is proposed a paper tube 131 for an aerosol-generating article 1 , the paper tube 131 having an inner wall defining an internal space, the internal space being empty or comprising an aerosol property modifying element, characterized in that it further comprises a compound having amino functional group at the inner wall, in the aerosol property modifying element or a combination thereof.

[0236] All the features and properties of the paper tube 131 described above in relation with the aerosol-generating article 1 apply to this paper tube 131.

[0237] Advantageously, aerosol exiting this paper tube 131 comprise less formaldehyde than an aerosol exiting a paper tube similar to this paper tube 131 but devoid of compound having amino functional group.

[0238] This paper tube 131 can be produced by the step c) of the method for producing the aerosolgenerating article 1 described above.

[0239] Therefore, it is proposed a method for producing this paper tube comprising the following step: c’) wrapping a paper so as to form a paper tube 131 comprising an inner wall defining an internal space, the internal space being empty or comprising an aerosol property modifying element characterized in that the compound having amino functional group is added before or after step c’), in particular before step c’): to the surface of the paper wrapped during step c’) corresponding to the inner wall, to the aerosol property modifying element comprised in the internal space, or to a combination thereof.

[0240] All the features and properties of the step c) described above in relation with the method for producing the aerosol-generating article 1 apply to the step c’) of this method.

[0241] The compound having amino functional group may be impregnated, coated or sprayed to the paper wrapped during step c’).

[0242] The compound having amino functional group may be impregnated, coated or sprayed to the aerosol property modifying element.

Examples

[0243] Example 1 : Manufacturing and testing of an aerosol-generating substrate having a fibrous support consisting of plant fibers.

[0244] Example 1 .1 : according to the invention

[0245] The following protocol is used to manufacture the aerosol-generating substrates of Examples 1 .1A to 1 .1 C whose properties are presented in Table 1 below.

[0246] A mixture of plant parts is brought into contact with water in the laboratory in a water bath at 85°C for 30 minutes. The plant extract is separated from the plant fibers by centrifugation.

The plant fibers are refined passed through a laboratory papermaking machine to obtain a base web.

[0247] The compound having amino functional group is mixed with nicotine, glycerol and optionnaly an organic acid to form a first mixture. The plant extract is pre heated to 43-45°C before being mixed with the first mixture to form a second mixture. This second mixture is heated to 48°C and stirred up to complete solubilization to form a solution. The solution is added to the base web by impregnation in a size press so as to obtain, after drying, an aerosol-generating substrate.

[0248] Example 1 .2: not according to the invention

[0249] The following protocol is used to manufacture the aerosol-generating substrate of Example 1 .2 whose properties are presented in Table 1 below.

[0250] A mixture of plant parts is brought into contact with water in the laboratory in a water bath at 85°C for 30 minutes. The plant extract is separated from the plant fibers by centrifugation.

[0251] The organic acid is mixed with nicotine and glycerol to form a mixture. The plant extract is pre heated to 40-45°C before mixing with the second mixture. This final mixture is heated to 48°C and stirred up to complete solubilization to form a solution.

[0252] The solution is added to the base web by impregnation in a size press so as to obtain, after drying, an aerosol-generating substrate. [0253] Example 1.3: Formaldehyde analysis

[0254] Formaldehyde screening was made by analysis of the aerosol-generating substrates of Examples 1.1 A to 1.1 C and Example 1.2 by an automated micro-scale chamber thermal desorption method and trapped on a Tenax® tube containing2,4-dinitrophenylhydrazine (DNPH) to derivatize carbonyls.

[0255] 100 mg of each aerosol-generating substrate were put to a thermal desorption (TD) chamber under air for 6 min at 250, 280 and 310°C. The DNPH tubes containing derivatized carbonyls were transferred to an autosampler tray for temporary storage and later eluted and analyzed by high performance liquid chromatography (HPLC) using a diode array detector (DAD) coupled to mass spectra (MS).

[0256] Three replicates were measured for each aerosol-generating substrates and the amount of formaldehyde in the aerosol generated by each aerosol-generating substrate is calculated.

[0257] Table 1 below presents the reduction of the amount of formaldehyde in the aerosol generated by the aerosol-generating substrates of Examples 1 .1 A, 1.1 B or 1.1 C in comparison with the amount of formaldehyde in the aerosol generated by the aerosol-generating substrate of Example 1 .2.

[0258] As evidenced in Table 1 , in comparison to the amount of formaldehyde in the aerosol generated by the aerosol-generating substrate of Example 1.2, the amount of formaldehyde in the aerosol generated by each of the aerosol-generating substrates of Examples 1 .1 A to 1 .1 C is reduced by more than about 50%.

[0259] Moreover, acidic properties of glutamic acid and aspartic acid help to obtain needed pH level for nicotine stabilization without addition of other acidic compounds.

[0260] Example 2: Manufacturing and testing of an aerosol-generating substrate having a fibrous support consisting of cellulosic fibers.

[0261] Example 2.1 : according to the invention

[0262] The following protocol is used to manufacture the aerosol-generating substrate of Example 2.1 whose properties are presented in Table 2 below.

[0263] Cellulosic fibers are passed through a laboratory papermaking machine to obtain a base web.

[0264] The amino acid is mixed with nicotine to form a mixture. Glycerol is then added to this mixture to form a second mixture. Water is added to this second mixture. This final mixture is heated to 48°C and stirred up to complete solubilization of the solution.

[0265] The solution is added to the base web by impregnation in a size press so as to obtain, after drying, the aerosol-generating substrate.

[0266] Example 2.2: not according to the invention

[0267] The following protocol is used to manufacture the aerosol-generating substrate of Example 2.2 whose properties are presented in Table 2 below. [0268] The cellulosic fibers are passed through a laboratory papermaking machine to obtain a base web.

[0269] The organic acid is mixed with nicotine to form a mixture. Glycerol is then added to this mixture to form a second mixture. Water is added to this second mixture. This final mixture is heated to 48°C and stirred up to complete solubilization of the solution.

[0270] The solution is added to the base web by impregnation in a size press so as to obtain, after drying, the aerosol-generating substrate.

[0271] Example 2.3: Formaldehyde analysis.

[0272] The same analysis as in Example 1 .3 is performed to determine the amount of formaldehyde generated by the aerosol-generating substrates of Example 2.1 and 2.2.

[0273] Table 2 below presents the reduction of the amount of formaldehyde in the aerosol generated by the aerosol-generating substrate of Example 2.1 in comparison to the amount of formaldehyde in the aerosol generated by the aerosol-generating substrate of Example 2.2.

[0274] As evidenced in Table 2, in comparison to the amount of formaldehyde in the aerosol generated by the aerosol-generating substrate of Example 2.2, the amount of formaldehyde in the aerosol generated by the aerosol-generating substrate of Example 2.1 is reduced by more than about 50%.

[0275] Moreover, acidic properties of glutamic acid help to obtain needed pH level for nicotine stabilization without addition of other acidic compounds.

[0276] Example 3: Manufacturing and testing of a filter media

[0277] Example 3.1 : wetlaid process

[0278] A base web was produced with bleached softwood fibers by a wetlaid process. A portion of the base web was impregnated via size-press with an agueous solution of sodium glycinate, as compound having amino functional group, to obtain an impregnated base web. The total content by weight of solids of sodium glycinate in the impregnated base web was 15%. A filter media was produced from the impregnated base web by a conventional process.

[0279] A base web was produced with bleached softwood fibers by a wetlaid process. A portion of the base web was impregnated via size-press with an agueous solution of polyethylene-imine, as compound having amino functional group, to obtain an impregnated base web. The total content by weight of solids of polyethylene-imine in the impregnated base web was 10%. A filter media was produced from the impregnated base web by a conventional process.

[0280] Example 3.2: airlaid process

[0281] A base web was produced with bleached softwood fluff fibers by an airlaid process. A solution of natural binder and sodium glycinate, as compound having amino functional group, was sprayed in the base web to obtain a sprayed base web. The dry weight ratio of natural bindensodium glycinate in the sprayed base web was 1 :1. The total content by weight of solids of sodium glycinate in the sprayed base web was 15% . A filter media is produced from the sprayed base web by a conventional process.

[0282] A base web was produced with bleached softwood fluff fibers by an airlaid process. A solution of natural binder and polyethylene-imine, as compound having amino functional group, is sprayed in the base web to obtain a sprayed base web. The dry weight ratio of natural binder: polyethyleneimine in the solution is 1 :1 . The total content by weight of solids of polyethylene-imine in the sprayed base web is 10%. A filter media is produced from the sprayed base web by a conventional process.

[0283] Example 3.3: Formaldehyde analysis

[0284] During a vaping test, aerosol-generating articles were produced with: an aerosol-generating substrate of Example 1.2 and a filter media manufactured in

Example 3.1 comprising sodium glycinate, an aerosol-generating substrate of Example 1.2 and a filter media manufactured in

Example 3.1 comprising polyethylene-imine, an aerosol-generating substrate of Example 1.2 and a filter media manufactured in

Example 3.2 comprising sodium glycinate, an aerosol-generating substrate of Example 1.2 and a filter media manufactured in

Example 3.2 comprising polyethylene-imine, an aerosol-generating substrate of Example 1.2 and a filter media manufactured as in

Example 3.1 but without compound having amino functional group, an aerosol-generating substrate of Example 1.2 and a filter media manufactured as in

Example 3.2 but without compound having amino functional group.

[0285] The aerosol of these articles is collected and formaldehyde from the collected aerosol are derivatized in DNPH and analyzed by HPLC according to ISO 21160 and ISO 23922.

[0286] Sodium glycinate decreases the formaldehyde content by 73% for the filter media produced from the impregnated base web and 60% for the filter media is produced from the sprayed base web.

[0287] Polyethylene-imine decreases the formaldehyde content by 52% for the filter media produced from the impregnated base web and 40% for filter media is produced from the sprayed base web.

[0288] Example 4: Manufacturing and testing of a cooling zone.

[0289] Example 4.1 : wetlaid process

[0290] A base web was produced with bleached softwood fibers by a wetlaid process. A portion of the base web was coated via bar coating method with an agueous solution of sodium glycinate, as compound having amino functional group, to obtain a coated base web. The total content by weight of solids of sodium glycinate in the coated base web was 15%. A paper tube was produced from the coated base web by a conventional process.

[0291] A base web was produced with bleached softwood fibers by a wetlaid process. A portion of the base web was coated via bar coating method with an agueous solution of polyethylene-imine, as compound having amino functional group, to obtain a coated base web. The total content by weight of solids of polyethylene-imine in the coated base web was 10%. A paper tube was produced from the impregnated base web by a conventional process.

[0292] Example 4.2: Formaldehyde analysis

[0293] During a vaping test, aerosol-generating articles were produced with: an aerosol-generating substrate of Example 1.2 and the paper tube manufactured in

Example 4.1 comprising sodium glycinate, an aerosol-generating substrate of Example 1.2 and the paper tube manufactured in Example 4.1 comprising polyethylene-imine, or an aerosol-generating substrate of Example 1 .2 and a paper tube manufactured as in Example 4.1 but without compound having amino functional group.

[0294] The aerosol of these articles is collected and formaldehyde from the collected aerosol are derivatized in DNPH and analyzed by HPLC according to ISO 21160 and ISO 23922 adapted to aerosol-generated article.

[0295] Sodium glycinate decreases the formaldehyde content by 30%. Polyethylene-imine decreases the formaldehyde content by 20%.

[0296] [Table 1]

0297] [Table 2]

Claims

[Claim 1] An aerosol-generating article (1) comprising:

- an aerosol-generating zone (11) comprising an aerosol-generating substrate (11 1),

- an aerosol-filtering zone (12) comprising a filter media (121), and

- a cooling zone (13) between the aerosol-generating zone (11) and the aerosol-filtering zone (12), wherein the aerosol-generating substrate (111) has a pH from 4.9 to 7.0, and comprises:

- an aerosol-generating agent,

- nicotine, a salt of nicotine or a mixture thereof, wherein the cooling zone (13) is defined by an inner wall of a paper tube (131), said cooling zone (13) being empty or comprising an aerosol property modifying element, and characterized in that it further comprises a compound having amino functional group in the aerosolgenerating substrate (11 1), in the filter media (121), at the inner wall of the paper tube (131), in the aerosol property modifying element or a combination thereof.

[Claim 2] The aerosol-generating article (1) according to claim 1 wherein the compound having amino functional group is an amino acid, a peptide, a protein, an amino sugar, urea, an urea derivative, an amino polysaccharide, an inorganic ammonium compound, a nitrogen-containing polymer, a polyamine or a mixture thereof.

[Claim 3] The aerosol-generating article (1) according to claim 1 or claim 2 wherein the compound having amino functional group is:

- an amino acid being glutamic acid, aspartic acid, alanine, asparagine, isoleucine, lysine, glycine, cysteine, arginine, homocysteine, isoleucine, leucine, glutamine, methionine, phenylalanine, histidine, proline, serine, valine, threonine or a mixture thereof,

- a peptide being glutamine peptide, polyglutamic acid peptide, glycine soja peptide or a mixture thereof,

- a protein being basic proteins hydrolysates, protein fibers, glycoprotein or a mixture thereof,

- an amino sugar being glucosamine, galactosamine, trehalosamine or a mixture thereof,

- an amino polysaccharide being chitin, chitosan, amino cellulose, amino chitosan, aminoethylcellulose, etherified starch with alkylamine, regenerated cellulose spun with a polyamine or a mixture thereof,

- an inorganic ammonium compound being an ammonium salt, an ammonium phosphate, a ammonium metal phosphates or a mixture thereof,

- a nitrogen-containing polymer being polyethylene-imine, polystyrene-acrylonitrile, polyacrylonitrilebutadiene-styrene,

- a polyamine may be alkyl amine, alkyl diamine, fatty alkyl diamine, or a mixture thereof, or

- a mixture thereof.

[Claim 4] The aerosol-generating article (1) according to any one claim 1 to 3, wherein the aerosolgenerating substrate 111 comprises a compound having amino functional group chosen from glutamic acid, aspartic acid, glutamine, glycine, a salt of glycine, polyglutamic acid peptide, casein fibers, soja fibers, glucosamine or a mixture thereof.

[Claim 5] The aerosol-generating article (1) according to claim 4, wherein the total content by weight of solids of compound having amino functional group in the aerosol-generating substrate (111 ) is from 0.3% to 25%.

[Claim 6] The aerosol-generating article (1) according to any one claim 1 to 5, wherein the aerosolgenerating substrate (11 1) comprises a plant extract.

[Claim 7] The aerosol-generating article (1) according to any one claim 1 to 6, wherein the cooling zone (13) comprises a compound having amino functional group chosen from a salt of glycine, amino cellulose, polyethylene-imine, fatty alkyl diamine or a mixture thereof.

[Claim 8] The aerosol-generating article (1) according to claim 7, wherein the total content by weight of solids of compound having amino functional group in the cooling zone (13) is from 1 % to 40%.

[Claim 9] The aerosol-generating article (1) according to any one claim 1 to 8, wherein the filter media (121) comprises a compound having amino functional group chosen from glycinate, amino cellulose, polyethylene-imine, fatty alkyl diamine or a mixture thereof.

[Claim 10] The aerosol-generating article (1) according to claim 9, wherein the total content by weight of solids of compound having amino functional group in the filter media (121) is from 1 % to 40%.

[Claim 11] A method for producing an aerosol-generating article (1) as defined in any one of claim 1 to 10 comprising the following steps: a) producing an aerosol-generating substrate (1 11), b) producing a filter media (121), c) forming a cooling zone (13) between an aerosol-generating zone (11) and an aerosolfiltering zone (12) by: wrapping a wrap paper around a portion of the aerosol-generating substrate (11 1) and a portion of the filter media (121) thereby obtaining the aerosol-generating article (1), wherein the wrap paper at the cooling zone (13) forms the paper tube (131), or placing a paper tube (131) between the aerosol-generating substrate (111) and the filter media (121), then wrapping a wrap paper around a portion of the aerosol-generating substrate (11 1), the paper tube (131) and a portion of the filter media (121) thereby obtaining the aerosol-generating article (1), characterized in that the aerosol-generating substrate (111) produced during step a), the filter media (121) produced during step b), the cooling zone (13) formed during step c) or a combination thereof comprises the compound having amino functional group.

[Claim 12] An aerosol-generating substrate (111) having a pH from 4.9 to 7.0 and comprising:

- a fibrous support comprising cellulosic fibers, plant fibers or a mixture thereof, - an aerosol-generating agent,

- nicotine, a salt of nicotine or a mixture thereof, characterized in that it further comprises a compound having amino functional group.