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WO2025212346A1 - Capture de grille d'images cardinales pour la détection et la surveillance du strabisme - Google Patents

Capture de grille d'images cardinales pour la détection et la surveillance du strabisme

Info

Publication number
WO2025212346A1
WO2025212346A1 PCT/US2025/021618 US2025021618W WO2025212346A1 WO 2025212346 A1 WO2025212346 A1 WO 2025212346A1 US 2025021618 W US2025021618 W US 2025021618W WO 2025212346 A1 WO2025212346 A1 WO 2025212346A1
Authority
WO
WIPO (PCT)
Prior art keywords
eye
images
image
display
fixation point
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2025/021618
Other languages
English (en)
Inventor
Dimitri Azar
Supriyo Sinha
Allister F. Mcguire
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Verily Life Sciences LLC
Original Assignee
Verily Life Sciences LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verily Life Sciences LLC filed Critical Verily Life Sciences LLC
Publication of WO2025212346A1 publication Critical patent/WO2025212346A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/113—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/02—Subjective types, i.e. testing apparatus requiring the active assistance of the patient
    • A61B3/08—Subjective types, i.e. testing apparatus requiring the active assistance of the patient for testing binocular or stereoscopic vision, e.g. strabismus
    • A61B3/085—Subjective types, i.e. testing apparatus requiring the active assistance of the patient for testing binocular or stereoscopic vision, e.g. strabismus for testing strabismus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/14—Arrangements specially adapted for eye photography
    • A61B3/145—Arrangements specially adapted for eye photography by video means
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/01—Head-up displays
    • G02B27/017—Head mounted

Definitions

  • an eye care professional collects a grid of photographs in which the patient looks at a center point and then outwards in forty-five- degree steps (aligned to the horizontal and vertical axes). This allows diagnosis of certain ocular pathologies such as strabismus. Strabismus refers to a misalignment of the eyes in which the eyes do not align to look at the same thing (i.e., incomitant gaze). For example, one eye is fixed on what the person intends to look at (the fixing eye) and the other eye is looking at something else (the deviated eye). An ECP may check for strabismus by holding the patient’s head still and having them follow a finger or light as it moves through various gaze positions.
  • the technique offers the ability to easily control the eye fixation during an exam and to synchronize the capture of a photo of the eye with the patient’s eye gaze.
  • a device that allows separate images to be presented to each eye (e.g., a head mounted display)
  • fixation points are presented to which the user is instructed to attend.
  • the fixation points may be presented binocularly or monocularly.
  • images are captured of the eyes (e.g., by a built-in camera(s)). Those images are then displayed as a map (e.g., a rectilinear grid) for presentation where each image’s location corresponds to the location of the fixation point.
  • the presented fixation point could be provided as an annotation.
  • the images may be paired with those of the other eye even if the eyes are imaged separately, or as two separate maps of each eye.
  • the images may be superimposed on a false image of a face to give context for the ECP.
  • the images may be presented raw as captured or edited for clarity or emphasis (e.g., removing corneal glints, positioning the eyes in the face properly) or adjusting contrast, brightness or color of the image towards borders to better match with false images of the face.
  • the ECP may then examine the mapped images to look at, for example, the presence or severity of strabismus based on whether the gaze of each eye is the same/different, or other ocular pathologies or conditions.
  • the disclosure is directed to an eye examination apparatus comprising: a virtual reality device configured to be worn on a user’s head, the virtual reality device having a housing and a display operable to display a fixation point to an eye of the user that corresponds to any one of a number of diagnostic gaze positions; and an imaging device coupled to the housing that is operable to capture an image (or series of images or videos) of the eye viewing the fixation point for use in examining the eye for an ocular condition.
  • the imaging device may include a camera integrated into the housing.
  • the image captured by the imaging device is of a right eye of the user, and the apparatus further comprises a second imaging device operable to capture an image of a left eye viewing the fixation point.
  • the image of the right eye and the image of the left eye are captured at a same time.
  • the image of the right eye and the image of the left 3960-P498WO 2 eye are superimposed on an image of a face that is examined by an ECP to evaluate whether the ocular condition of strabismus is present.
  • the fixation point is a first fixation point displayed on a first display to a right eye
  • the apparatus further comprises a second fixation point displayed on a second display to a left eye
  • the imaging device captures an image of the right eye and the left eye viewing the first fixation point and the second fixation point, respectively.
  • the fixation point is a first fixation point corresponding to a first diagnostic gaze position
  • the display is operable to display a second fixation point corresponding to a second diagnostic gaze position.
  • the image may be a first image of the eye viewing the first fixation point
  • the imaging device is further operable to capture a second image of the eye viewing the second fixation point.
  • the first image and the second image are arranged in a grid used by an ECP to examine the eye for the ocular condition of strabismus.
  • the fixation point may include a shape operable to be displayed at a number of locations on the display selected to corresponds to any one of a number of diagnostic gaze positions.
  • the number of fixation points are displayed in a series on a first display to a right eye
  • the apparatus further comprises a number of fixation points displayed in a series on a second display to a left eye
  • the imaging 3960-P498WO 3 device captures images of the right eye and the left eye viewing the series of fixation points.
  • the images are arranged in a grid comprising at least nine images that are arranged in a three-by-three grid to correspond to the diagnostic gaze positions.
  • the grid may be used by an eye care professional to examine the eye for the ocular condition of strabismus.
  • the grid may include a first grid of images of the right eye and a second grid of images of the left eye.
  • FIG.1 illustrates a side perspective view of a user wearing a VR headset.
  • FIG.2 illustrates a cross-sectional top view of the user wearing the VR headset of FIG.1.
  • FIG. 3 illustrates a top schematic view of an example system for performing an eye examination using the VR headset of FIG.2.
  • FIG. 4 illustrates a block diagram of an example operation for performing an eye examination using a VR headset.
  • FIG.5 illustrates a block diagram of an example system for performing an eye examination using a VR headset.
  • the exemplary term “below” can encompass both an orientation of above and below.
  • the device may be otherwise oriented (e.g., rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
  • the singular forms “a”, “an”, and “the” are intended to include the plural forms as well, unless the context indicates otherwise.
  • the terms “comprises” and/or “comprising” specify the presence of stated features, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and/or groups thereof.
  • FIG.1 depicts an eye examination system including a user (wearer) 102 wearing a virtual reality (VR) device or headset 104 which as modified below can be used to perform various ophthalmic examinations on the eyes of the wearer, including examinations to determine the presence or severity of strabismus (among other conditions). The modifications enable the use of a relatively low-cost solution in the form of an otherwise consumer grade VR headset.
  • FIG. 2 is a cross-sectional top schematic view of the system of FIG.1 having an integrated eye examination system.
  • the VR headset 104 when the VR headset 104 is positioned on the user’s head (as shown in FIG.1), the user’s eyes 202A, 202B are aligned with the various optical components of the VR headset 104 for performing an eye examination (e.g., an examination to monitor strabismus).
  • the VR headset 104 may include a housing 203 that contains, or is otherwise coupled to, the various optical components. Housing 203 is positioned over the eyes of the user and is removably secured to the head of the user using a strap as shown in FIG.1, or other similarly suitable attachment mechanism that can removably secure housing 203 onto the user’s head.
  • the various optical components may include, among others, one or more VR displays 204A, 204B that operate like a traditional VR display to display an image that is viewed by a respective one of the eyes 202A-B of the user.
  • the components may further include one or more of an imaging device 206A, 206B integrated into housing 203. Imaging device 206A, 206B may be arranged within housing 203 at any location or position relative to each of eyes 202A, 202B suitable for capturing an image of the eye 202A, 202B when viewing the image displayed on displays 204A-B.
  • imaging device 206A may be arranged in front of eye 202A (e.g., right eye) near display 204A and be used to capture an image of eye 202A. It is contemplated that the image may include a photo, video, or a series of photos of videos.
  • imaging device 206B may be arranged in front of eye 202B (e.g., left eye) near display 204B and be 3960-P498WO 6 used to capture an image of eye 202B. Other locations and/or positions of imaging device 206A-B, however, are further contemplated.
  • imaging devices 206A-B may be positioned next to eyes 202A-B and reflectors may be incorporated into housing 203 to reflect an image of each eye 202A-B back to imaging devices 204A-B so that imaging devices can capture an image of each of eyes 202A-B.
  • images may be displayed at different locations within displays 202A-B and images of eyes 202A-B at different angles looking at the images are captured by the imaging devices 206A-B. The captured images may then be arranged in a map or grid of photographs or videos that can be evaluated by the ECP to determine the presence or severity of strabismus.
  • FIG.3 illustrates a top schematic view of the VR headset of FIG. 2 adapted to monitor for and/or detect strabismus.
  • each of eyes 202A-B are directed toward a respective one of displays 204A-B.
  • Each display 204A-B may then display an image, for example in the form of a fixation point that directs the eyes to one of any of the diagnostic positions of gaze (or diagnostic gaze positions) used to assess ocular function.
  • Representative diagnostic positions of gaze may include, but are not limited to, directing the eyes to a primary position (e.g., looking straight ahead), secondary positions (e.g., looking inward, outward, upward or downward), up/right, right, down/right, down/left, left and up/left.
  • FIG. 3 illustrates display 204A displaying images at three fixation points 302A-1, 302A-2, 302A-3 which correspond to three different diagnostic positions of gaze.
  • display 204B displays images at three fixation points 302B-1, 302B-2, 302B-3 which correspond to three different diagnostic positions of gaze.
  • the positions may be, for example, a center gaze position (e.g., illustrated by fixation points 302A-2, 302B-2) followed by right/left outward gaze positions (e.g., fixation points 302A-1, 302B-1 and 302A-3, 302B-3).
  • the different gaze positions may be approximately 45 degrees relative to the center gaze position (aligned to the horizontal and vertical axes).
  • the fixation points 302A-1, 302A- 2, 302A-3, 302B-1, 302B-2 and 302B-3 (as well as any remaining fixation points) may be presented binocularly or monocularly in series.
  • images are captured of the eyes 202A-B by the imaging devices 206A-B.
  • the imaging devices may capture the images of each of eyes 202A-B fixated on fixation points corresponding to the same diagnostic position of gaze at the same time.
  • Imaging devices 206A-B may be, for example, built in cameras, image sensors or any other type of device suitable for capturing an image of eyes 202A-B when viewing the fixation points.
  • the images may be a series of photos or videos.
  • the images could be taken by the imaging devices 206A-B in the visible or in the near- infrared (IR) range.
  • IR near- infrared
  • imaging devices 206A- B and two displays 204A-B are shown integrated into housing 203, one display may display the fixation points to both eyes and/or one imaging device may be used to capture images of both eyes when viewing the fixation points.
  • the images captured by imaging devices 204A-B are then displayed in a map or rectilinear grid 304 of images or tiles 306 in which the eye gaze imaged corresponds to the location of the fixation point. For example, a single image per location or fixation point could be selected and displayed in grid 304.
  • grid 304 may be a three-by-three grid of at least nine images or tiles 306 as shown.
  • grid 304 could be different (larger or smaller) depending on the application.
  • two maps or grids 304 corresponding to the location of fixation points viewed by each eye separately could be generated. Regardless of the number of images and/or grids, it should be understood that the images should be placed at positions corresponding to the gaze angle to provide an intuitive presentation of the direction of gaze to the ECP for assessment.
  • image tile 306A presented in grid 304 is an image of eyes 202A and 202B looking to the left (e.g., 45 degrees from a center gaze position) and viewing fixation points 302A-3 and 302B-3, respectively.
  • Image tile 306B presented in grid 304 is an image of eyes 202A and 202B looking straight ahead and viewing fixation points 302A-2 and 302B-2 (e.g., the center gaze position).
  • Image tile 306C presented in grid 304 is an image of eyes 202A and 202B looking to the right (e.g., 45 degrees from the center gaze position) and viewing fixation points 302A-1 and 302B-1.
  • the remaining images or tiles represented in grid 304 illustrate images of eyes 202A-B viewing fixation points corresponding to the six remaining diagnostic positions of gaze.
  • the presented fixation point could be provided as an annotation.
  • the captured images may be paired with those of the fellow eye as shown in grid 304 even if eyes 202A-B are imaged 3960-P498WO 8 separately.
  • the images may be superimposed on a false image of a face to give context for the ECP.
  • the images may be presented raw as captured or edited for clarity or emphasis (e.g., removing corneal glints, positioning the eyes in the face properly) or adjusting contrast, brightness or color of image towards borders to better match with false image of a face.
  • two maps may be generated, one for each fixated eye (left and right).
  • fixation points may be displayed as circular, dot or other basic images on display 204A-B, or they could be pictures, graphics or other interesting shapes (e.g., a spaceship, a farm animal, etc.) to better help fixate the gaze of a younger patient.
  • FIG. 4 illustrates a block diagram of one representative process for performing an eye examination to detect strabismus using a VR headset, as previously discussed.
  • process 400 includes an initial operation 402 of displaying an image such as a fixation point that directs the eye gaze to any number of the cardinal diagnostic gaze positions on a display of the VR headset as previously discussed.
  • the fixation point may be an image of any type of shape such as a dot, or any type of object, that is suitable to fix the gaze of the user at a particular diagnostic gaze position (e.g., center, 45 degrees to the left, 45 degrees to the right, etc.).
  • a diagnostic gaze position e.g., center, 45 degrees to the left, 45 degrees to the right, etc.
  • An image of the user’s eye at the fixation point is then captured at operation 406.
  • the VR headset may automatically detect that the eye is at the fixation point (e.g., using an eye tracker) and capture the image using an imaging device such as a camera or image sensor integrated into the VR headset as previously discussed.
  • the process returns to operation 402 for display of another fixation point at a different location corresponding to another diagnostic gaze position.
  • the second fixation point may be at a location approximately 45 degrees from the previous fixation point.
  • An image of the user’s eye at the second fixation point is captured at operation 406. This process of operations 402-406 may continue until images of each of the user’s eyes at all fixation points corresponding to all diagnostic gaze positions are captured. Once all the images for each eye are captured, a grid or map based on the images is generated as previously discussed at operation 408.
  • FIG.5 illustrates a block diagram of an example system for measuring corneal topography using a VR headset.
  • system 500 may include headset 104 positioned on the user’s head as previously discussed. Headset 104 may be communicatively coupled to a remote computer or other electronic device 502 allowing for control of the functions of headset 104 and for performing the eye examination.
  • remote device 502 may be equipped with a transmitter/receiver 504 for communicating (e.g., wireless internet communication) with headset 104.
  • Device 502 may further include a processor 506 connected to a memory 508 that stores a software application or algorithm for conducting an ocular examination (e.g., test for strabismus) as described herein.
  • the medical professional may perform the operation 400 described in reference to FIG.4.
  • the headset display may present a number of fixation points to direct the user’s gaze and the camera may capture images of the user’s gaze at the different fixation points.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Multimedia (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Human Computer Interaction (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

L'invention concerne un appareil d'examen oculaire comprenant : un dispositif de réalité virtuelle configuré pour être porté sur la tête d'un utilisateur, le dispositif de réalité virtuelle ayant un boîtier et un afficheur utilisable pour afficher un point de fixation pour un œil de l'utilisateur qui correspond à l'une quelconque d'un certain nombre de positions de regard de diagnostic ; et un dispositif d'imagerie couplé au boîtier qui est utilisable pour capturer une image de l'œil regardant le point de fixation pour une utilisation dans l'examen de l'œil pour un état oculaire.
PCT/US2025/021618 2024-04-03 2025-03-26 Capture de grille d'images cardinales pour la détection et la surveillance du strabisme Pending WO2025212346A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202463573773P 2024-04-03 2024-04-03
US63/573,773 2024-04-03

Publications (1)

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WO2025212346A1 true WO2025212346A1 (fr) 2025-10-09

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Family Applications (1)

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PCT/US2025/021618 Pending WO2025212346A1 (fr) 2024-04-03 2025-03-26 Capture de grille d'images cardinales pour la détection et la surveillance du strabisme

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200088630A (ko) * 2019-01-15 2020-07-23 주식회사 엠투에스 가상현실 기반의 시야검사 방법 및 시스템
WO2020198491A1 (fr) * 2019-03-28 2020-10-01 University Of Miami Détermination de défauts de vision et amélioration
KR20210045530A (ko) * 2019-10-16 2021-04-27 그리드스페이스(주) Vr 타입 웨어러블 치료장치
US20230218159A1 (en) * 2020-06-11 2023-07-13 Eadie Technologies Inc. System, Method, and Head-Mounted Device for Visual Field Testing
US20230284899A1 (en) * 2022-03-10 2023-09-14 Icahn School Of Medicine At Mount Sinai Head-Mounted System for Measuring Ptosis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200088630A (ko) * 2019-01-15 2020-07-23 주식회사 엠투에스 가상현실 기반의 시야검사 방법 및 시스템
WO2020198491A1 (fr) * 2019-03-28 2020-10-01 University Of Miami Détermination de défauts de vision et amélioration
KR20210045530A (ko) * 2019-10-16 2021-04-27 그리드스페이스(주) Vr 타입 웨어러블 치료장치
US20230218159A1 (en) * 2020-06-11 2023-07-13 Eadie Technologies Inc. System, Method, and Head-Mounted Device for Visual Field Testing
US20230284899A1 (en) * 2022-03-10 2023-09-14 Icahn School Of Medicine At Mount Sinai Head-Mounted System for Measuring Ptosis

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