[go: up one dir, main page]

WO2025210637A1 - Capteur de poignet pour mesurer un paramètre physiologique - Google Patents

Capteur de poignet pour mesurer un paramètre physiologique

Info

Publication number
WO2025210637A1
WO2025210637A1 PCT/IL2025/050296 IL2025050296W WO2025210637A1 WO 2025210637 A1 WO2025210637 A1 WO 2025210637A1 IL 2025050296 W IL2025050296 W IL 2025050296W WO 2025210637 A1 WO2025210637 A1 WO 2025210637A1
Authority
WO
WIPO (PCT)
Prior art keywords
wrist
pad
sensors
pliable
wristband
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/IL2025/050296
Other languages
English (en)
Inventor
Eldad Shemesh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardiacsense Ltd
Original Assignee
Cardiacsense Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiacsense Ltd filed Critical Cardiacsense Ltd
Publication of WO2025210637A1 publication Critical patent/WO2025210637A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/024—Measuring pulse rate or heart rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0295—Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue

Definitions

  • This disclosure concerns a device, fitting over the wrist of a wearer for measuring physiological parameters.
  • EP 3923089A1 discloses a watch strap that is formed from a flexible material.
  • the watch strap includes an electronics module that is embedded within the flexible material.
  • the electronics module includes a sensor for acquiring sensor data that may include pulse rate and blood oxygenation level.
  • US 8,870,448B2 discloses a watch strap having a comfort pad with a longitudinal opening that is arranged on the inner surface of the strap towards one of the ends of the strap.
  • WO 2016/125034A1 discloses a smart watchband with integrated electronics that can be attached to any mechanical or digital wristwatch.
  • the watchband has a flexible circuit board and a variety of sensors including an embedded heart rate sensor, body temperature sensor, ambient temperature sensor and some other elements.
  • the watchband is powered by a rechargeable battery.
  • the present disclosure provides a device for measuring a physiological parameter of a subject.
  • the device comprises a pliable pad associated with sensors, e.g. applied on a surface thereof.
  • the sensors are configured for measuring signals that are indicative of pressure applied on the pliable pad or on the sensors.
  • the pliable pad is designed so as to be capable of bending to conform with the shape of the wrist of the subject it engages with. By conforming with the shape of the wrist, the pliable pad increases the sensitivity of the measurement by the sensors.
  • the sensors are intended to be positioned on the wrist of the subject so as to be able to sense the minute deformations of the skin due to change of blood flow in the blood vessels below the skin, e.g. the radial artery.
  • the pliable pad is coupled to a coupling member that is configured to allow fitting of the device to the wrist of the subject and fixing the pliable pad at a desired position for obtaining the measurements.
  • the carrier has a contact surface for contacting a skin portion of a subject that is deformed in consequence of skin deformations as a result of physiological properties, for example owing to changes of blood flow or blood pressure within blood vessels below the skin portion.
  • deformations of the skin portion which can be minor changes resulting from blood volume changes in arteries such as the radial artery or in small blood vessels such as arterioles within a tissue of the wrist of the subject, cause respective deformations of said contact surface that is picked up by the sensor.
  • the pressure applied on the contact surface resulting in a change of one or more electrical parameters of the planar sensor element, e.g. the graphene layers, such as its impedance, that is measurable.
  • the pressure variation exerted on the contact surface over time can be determined, which is indicative of the physiological parameter.
  • the physiological parameter, measurable by this and other embodiments of this disclosure may be heartbeat, heartbeat-related parameter, or respiration rate, all of which give rise to pressure waves that travel in blood vessels and give rise to local deformations of the skin.
  • the signal that is obtained by the sensor device of this disclosure may be a waveform signal resulting from such changes on said skin portion.
  • a variety of physiological parameters can be determined and also movements of muscles or tendons that can be regarded as artifact movements that are required to be eliminated during measurements of physiological parameters by the sensor of the present disclosure or other sensors associated therewith, e.g. sensors that share the same contact surface.
  • physiological parameters that are reflected in pressure waves travelling along blood vessels there may also be others that are reflected in some deformation of the skin, such as deformations that are caused by muscle activity.
  • the physiological parameter is one causing skin deformations, which may be minute deformations including such resulting from minute muscle twitching or from a pressure wave travelling in the underlying vasculature.
  • the physiological parameter is a cardiovascular parameter.
  • said physiological parameter is a heartbeat-induced pressure change in the vasculature in said skin portion.
  • said carrier is pliable, flexible or reversibly deformable.
  • the sensor device further comprises an electronic circuitry coupled to said layer and configured for reading the at least one electrical parameter of said layer, and for outputting a signal corresponding thereto or corresponding to a change in said parameter, which may be data representative of the signal or change and transmitted either to a remote device, e.g. a smart phone or a computer, or to a cloud server.
  • a remote device e.g. a smart phone or a computer, or to a cloud server.
  • said electronic circuitry comprises a processor configured for processing the read at least one electrical parameter for determining said physiological parameter.
  • the outputting of a signal corresponding thereto or corresponding to a change in said parameter comprises outputting data corresponding to or representative of said physiological parameter.
  • the sensor device further comprises a power source for providing power to the electronic circuitry.
  • the sensor device further comprises a wireless transmitting utility configured for transmitting an output signal to another device.
  • said wireless transmitting utility is a low-power Bluetooth transceiver.
  • the wireless transmitting utility is configured for transmitting said data signal to one or more of a smart watch, a mobile communication device and a computer.
  • the sensor device further comprises a wired transmitting utility configured for wired transmission of said data signal to an external device (e.g. smart watch).
  • a wired transmitting utility configured for wired transmission of said data signal to an external device (e.g. smart watch).
  • the sensor device is used for measuring artifact movements of the measures skin portion.
  • the measured artifact movements are used to indicate when the measurement of a physiological parameter, either measured by the sensor device or a sensor associated therewith, is valid or not. Namely, by identifying artifacts, invalid measurements can be neglected, and the measurement of the physiological parameter is not based on such neglected measurements.
  • the sensor device is embedded in a ring or other wearable for continuous measurement of any one of heart rate, pulse rate, respiration rate and blood pressure.
  • Yet another aspect of the present disclosure provides a method for measuring a physiological parameter from a skin portion of a subject.
  • the method comprises contacting, directly or indirectly, a contact surface of a sensor device with said skin portion.
  • the sensor device comprises: (1) a carrier, a base or a carrier base defining said contact surface, and (2) a patterned layer of graphene disposed on or embedded in said carrier, such that one or both of (i) pressure applied on said layer, and (ii) deformation of said layer, results in a change of at least one electrical parameter of said layer.
  • the method further comprises measuring said change of at least one electrical parameter and generating sensed data representative thereof; and outputting said sensed data for analysis to determine said physiological parameter.
  • the method further comprises analyzing said change of at least one electrical parameter of said layer for determining said physiological parameter.
  • said sensor device is any one of the above - described embodiments of the sensor device or any combination thereof.
  • the present disclosure provides a device for measuring physiological parameters, such as blood pressure.
  • the device of this disclosure makes use of a pad or small cushion (to be referred to herein as "pad'), that is fitted or that is configured to be fitted on an inner, wrist-facing side of a wristband, which may be an independent wristband or one serving as a watchband.
  • the pad has a pliable wrist-bearing surface that is placed against the wrist over a portion of the wrist that may comprise one or both of the radial or the ulnar artery.
  • the physiological parameters that are measured are such that give rise to small surface deformations of portions of the wrist on which the wrist-facing surface is placed and these, typically, but not exclusively, arising from pressure changes as a result of blood flow within the arteries or blood pressure pulses. Such deformations cause deformations of the wrist-facing surface and may give rise to small pressure changes within the pad. Such deformations of the wrist-facing surface or pressure changes within the pad are picked up by sensors and converted into signals that can then be processed and translated into a measure of a physiological parameter.
  • a device for measuring a physiological parameter that comprises a pliable pad and one or more sensors disposed within the pad.
  • the pad is fitted or is configured for fitting on a wrist-facing side of a wristband and has a wrist-bearing surface that is conformed or is comfortable to the topology of the wrist.
  • the pad is typically of a length such that when placed on the wrist it will cover an area of the wrist surface that includes one or both of the radial and ulnar arteries without the need for searching these arteries and exact positioning.
  • a wristband e.g. a watchband
  • the one or more sensors are disposed within or associated with said pad and are intended for sensing one or both of (i) change of pressure within the pad, and (ii) deformation of the wrist-bearing surface, and for issuing an output signal corresponding thereto indicative of said physiological parameter.
  • the device comprises a base that is attached to or is fitted over an inner, wrist-facing face of a wristband that extends along a wristband axis (which when worn extends circumferentially around the wrist) or is configured for such attachment or fitting.
  • the pliable pad may be attached or attachable to the base.
  • the device has typically, albeit not exclusively, two edges that extend along edges of the wrist band and has a width such that it is confined between the wristband’s side edges.
  • the pad is integrally formed on an inner side of said wrist band.
  • the device typically comprises an electronic utility for receiving and processing said output signal and for emitting a data signal based thereon.
  • the electronic utility may also, in some cases, be external to the device connectable to the sensor by wired or wireless communication (e.g. through low power Bluetooth).
  • the measured physiological parameter is blood pressure.
  • the pad by some embodiments is a fluid-filled enclosure having a pliable wristbearing surface.
  • the fluid may, for example, be a gas, liquid, a gel or a thick oily substance such as grease. It should, however, be noted that pad by some embodiments may not be an enclosure and have a uniform consistency.
  • the fluid-filled enclosure is filled with gas, e.g. air.
  • the gas may be pressurized to a certain pressure.
  • the fluid-filled enclosure is filled with liquid, e.g. water, or water-based solution.
  • liquid e.g. water, or water-based solution.
  • the fluid-filled enclosure is filled with gel.
  • the fluid filled enclosure is filled with a non-drying solution or a non-drying oil.
  • the fluid filled enclosure is filled with a non-volatile solution.
  • non-drying solution and “non-volatile solution” refer to materials that resist evaporation or hardening when exposed to air.
  • Non-drying solutions may include one of the following: greases (thick, lubricating substances), oils (liquid fats that don't easily evaporate), and resins (natural or synthetic sticky substances that may not harden quickly). These materials are often characterized by their stable, long-lasting consistency and their resistance to air drying or evaporation under normal conditions.
  • the advantage of using such non-drying solutions is due to the fact that the internal volume of the pliable pad may be not entirely fluidically sealed for exchange of small molecules, such as gas molecules or water molecules. Therefore, aqueous-based solutions may dry overtime and lose their pliable properties, which will affect the efficacy of the device.
  • the fluid filled enclosure is filled with grease.
  • the pad may be so configured that deformation of central portion of the wristbearing surface will not substantially deform edge portions thereof. This may be achieved, for example, by attachment or tight association of the edge portion to a rigid edge element of the base, by a rigid side wall of the pad, by other structural elements, by different blends of two or more substances that are used to form the wrist-bearing surface, by varying wall thickness of the wall of the enclosure that defines the wrist-bearing surface, etc.
  • the pliability of the wrist-bearing surface may, thus, vary between a central portion thereof towards its periphery.
  • the pad may be elongated and trace a circumferential portion of the wrist, along the wristband axis.
  • the device may have an overall arcuated shape to trace approximate contours of the wrist.
  • a sensor is one that comprises a pliable element that changes its impedance upon its deformation.
  • Said pliable element is electronically coupled to an electronic circuitry for measuring the impedance and/or changes in impedance and issuing an output signal corresponding thereto.
  • Said pliable element is fitted within said pad or is associated with the wrist-bearing surface such that one or both of (i) change of pressure of the fluid and (ii) deformation of the wrist fitting surface, deforms said pliable device.
  • Said pliable element may be fitted on the wrist-bearing surface or may be embedded within the pad, for example, just below the surface.
  • One example of such a pliable element is one that comprises a strain gauge or graphene.
  • the device may comprise two or more such elements. For example: two or more in a linear arrangement along the pad axis; two or more that are parallel to one another with respect to the pad axis; a 2D array of such elements, for example two parallel pairs arranged in series along the pad axis; etc.
  • a first of a parallel pair is overlying a portion of the wrist that is more proximal, with respect to the direction of arterial blood flow, than a second of the pair.
  • a device may be used, for example, for measuring a pulse wave velocity, by measuring the time of arrival of the pulse wave in two points with a known distance between them. Namely a pulse wave reaches and is measured first by one element and then, after a short delay, reaches and is measured by the other, providing a measure of the speed of propagation that may also be an indication of blood pressure.
  • the senor comprises a piezoelectric element.
  • the piezo electric element may be disposed on or against a flexible surface associated with said pad and that can, this, undergo some deformations upon one or both of (i) pressure changes within the pad and (ii) deformation of the wrist fitting surface.
  • the flexible pad is divided into two or more separate compartments, parallel to one another, and wherein each compartment comprises separate one or more of said sensors for measuring one or both of (i) change of pressure within the compartment, and (ii) deformation of the wrist fitting surface of said compartment, and for issuing an output signal corresponding thereto.
  • Such separate compartments may be arranged in parallel along the pad axis, configuring them for measuring pulse velocity in a manner analogous to that described above.
  • the device may comprise a wireless transmitting utility (e.g. a transceiver) configured for transmitting said data signal to another device, which may be one or more of a smart watch, a mobile communication device and a computer.
  • the wireless transmitting utility may include a low -power Bluetooth transceiver.
  • Such a wireless connection may also serve for the purpose of control, configuration or software update.
  • the connection to a smart watch for example, may also be wired.
  • the printed one or more sensors are covered by a protective cover.
  • the protective cover may be a thin film of the pliable pad or other protective cover material that ensures that the sensor is not damaged by the pressure applied on the pliable pad.
  • the protective cover is made of the same material as the pliable pad. Namely, a thin film of the pliable pad covers the one or more printed sensors.
  • the at least one light source and the at least one light detector are positioned such that their optical axes have at least a component that is normal to the plane spanned by the wrist-bearing surface.
  • the one or more sensors further comprise two or more strain gauge sensors spaced apart from one another.
  • the device further comprises one or more second type of sensors, the second type of sensors is a PPG sensor.
  • the light source and the light detector of the PPG sensor are arranged a long a line that is positioned between two strain gauge sensors. It is to be noted that there may be more than one PPG sensor that are positioned between two adjacent strain gauge sensors.
  • the pliable pad comprises a base surface opposite to the wrist-bearing face.
  • the base surface comprises wristband-bearing portions spaced apart from one another, facing away from the wrist-bearing face and intended to be positioned on a wristband, when the device is fitted on the wristband.
  • the wristbandbearing portions defines a wristband-bearing portions plane, and a plurality of voids are formed between said wristband-bearing portions plane and the base surface. Namely, a void is formed between two adjacent wristband-bearing portions.
  • the discontinuities are grooves that extend between opposite sides of the pad in a direction normal to a pad axis defined between first and second ends of the pliable pad, the sides of the pad are those that extend along an axis substantially parallel to the pad axis.
  • the at least one of the voids comprise two first sections flanking a second section, the inner end of the second portion is closer to the wrist-bearing surface than that of the two first sections.
  • the first sections are the sections that are defined in the periphery and extend from the side of the pliable pad to the second section that is in in between these two first sections.
  • the sections are continuous and there is no discernable transition between the first sections and the second section other than the shape and the depth of the sections. Namely, the second section is deeper than the first sections. This is made to allow the central portion of the pliable pad, and in particular the wrist-bearing surface, to be the most flexible as the thickness of the pliable pad in this portion is minimal.
  • the inner end of the second section has a general shape corresponding to that of said one of said one or more sensors.
  • the general shape of said one of said one or more sensors should be understood as that it encompasses the majority of the projection of said one of said one or more sensors, e.g. above 50%, 60%, 70%, or 80% of the projection.
  • the pliable pad is a single-piece molded or printed article.
  • the pliable pad is made of a pliable, flexible or elastomeric material.
  • the pliable pad is made of silicone -based material.
  • the pliable pad is made of silicone rubber.
  • said one or more sensors are attached to or fitted on said wrist-bearing surface. It is to be noted that the one or more sensors may be attached to the wrist-bearing surface while it is covered by a protective cover for protecting it.
  • the pliable pad is fitted on or is configured for fitting on a wrist-facing side of a wrist-fitting element, e.g. a wristband or bracelet.
  • the device further comprises a coupling member attached to or fitted over a wrist-fitting element, or a wristband or bracelet fitting element, that extends around the wrist or a portion thereof along an element axis or configured for such attachment or fitting, namely the coupling member comprises wristband receiving portions for receiving the wristband therethrough for said attachment or fitting.
  • the pliable pad is (i) attached to said coupling member, and (ii) extending along a pad axis parallel to said element axis. Said pad axis is the same axis as the pad axis defined between two ends of the wrist-bearing surface.
  • the coupling member is made of silicone- based material, such as silicone or silicone rubber.
  • the coupling member has greater hardness than the pliable pad.
  • said coupling member comprises two fitting or receiving portions extending from a body portion, each fitting portion having an opening for fitting around the wrist-fitting element or for receiving the wrist-fitting element therethrough. Therefore, the fitting portions, when the wrist-fitting element, e.g. a wristband, is received therethrough, have a first part that is on a wrist-facing side of the coupling member and a second part that is on an opposite side, namely the side facing away from the wrist of the subject.
  • the fitting portions and the body portion are typically elements of one integral structure.
  • each of the fitting portions comprises a wristfacing face.
  • One or both of the wrist-facing faces comprises a first ECG electrode for providing an ECG contact point while the device and the pliable pad bear against the skin of the subject.
  • the body comprises an external face and a vertical axis is defined normal to said external face, the vertical axis defined herein is the same vertical axis defined with respect to the opposite surface.
  • the one or more sensors are positioned at a greater extent from the external face than the wrist-facing faces along said vertical axis in a wrist direction, defining the direction to the wrist.
  • the body portion comprises an external face that comprises one or more second ECG electrodes, thereby allowing the subject to touch the second ECG electrode with a body part, such as a finger, from an opposite side of the body than the hand wearing the device to allow and ECG measurement by the first and second ECG electrodes.
  • the body portion when fitted or attached to the wristband, is entirely positioned at an outer side of the wristband, the outer side is being further away from the wrist than an inner side of the wristband.
  • the pliable pad is attached to, and typically only to, the wristband fitting portions.
  • the attachment is made to the parts of the wristband receiving portions that are on the inner side of the wristband. Therefore, the pliable pad is merely attached at its two ends, maintaining its freedom to bend in order to conform with the skin shape of the subject.
  • the pliable pad comprises wristband-bearing portions bearing against the wristband when it is attached to or fitted to the wristband. These wristband-bearing portions are typically the portions at the opposite surface formed by the ribs.
  • said wristband-bearing portions are defined by a base surface opposite the wrist-bearing surface.
  • a gap is spanned between the wrist-facing surface of the body portion of the coupling member and the wristband-bearing portions of the pliable pad.
  • the wristband or the wrist-fitting element that is received into the wrist-fitting portions fits through this gap such that it is sandwiched between the wrist-facing surface of the body portion of the coupling member and the wristband-bearing portions of the pliable pad. Therefore, when received, a portion of the wrist-fitting element extends through a first wrist-fitting portion, the gap, and the second wrist-fitting portion.
  • the coupling member is pliable or flexible.
  • said pliable pad is integrally formed on said wrist band.
  • said pad is integrally formed on the inner side of the wristband and extending along a wristband axis.
  • the device further comprises an electronic utility for receiving and processing said output signal and for emitting a data signal based thereon.
  • the physiological parameter is one causing skin deformations.
  • the physiological parameter is a cardiovascular parameter.
  • said physiological parameter is a heartbeat- induced pressure change in the vasculature in said skin portion or respiration rate.
  • said wrist-bearing surface has a varying pliability between a central portion thereof towards its periphery.
  • the flexibility or pliability of the wristbearing surface is higher in the central portion than in the periphery.
  • a sensor device for measuring a physiological parameter or a data indicative of said physiological parameter from a skin portion of a subject, the sensor device comprising: a carrier defining a contact surface for contacting directly or indirectly said skin portion; a patterned layer of graphene disposed on or embedded in said carrier, such that one or both of (i) pressure applied on said layer, and (ii) deformation of said layer, results in a change of at least one electrical parameter of said layer; wherein the change of the at least one electrical parameter of said layer is indicative of said physiological parameter or a change thereof.
  • a device for measuring a physiological parameter comprising: a pliable pad fitted or being configured for fitting on a wrist-facing side of a wristband, the pad having a pliable wrist-bearing surface and configured for placing against a portion of the wrist; and one or more sensors disposed within or associated with said pad for sensing at least one of (i) change of pressure within or on the pad, and (ii) deformation of the wristbearing surface, (iii) change of pressure applied on said one or more sensors or, (iv) deformation of said one or more sensors, and for issuing an output signal corresponding thereto indicative of said physiological parameter or a change thereof.
  • the device of embodiment 16 comprising: a base attached to or fitted over an inner, wrist-facing face of a wristband that extends along a wristband axis or configured for such attachment or fitting; and wherein said pad (i) being attached to said base, and (ii) extending between first and second edges thereof along a pad axis parallel to said wristband axis.
  • the electrical parameters are measured between two terminals 660A and 660B along the path of the graphene defined by the layer 656. It is to be noted that the measurement can be performed between any two points along the path of the graphene layer 656. Therefore, a pressure applied on the contact surface 654 causes a measurable change of the electrical parameters of the graphene layer 656 indicative of the pressure applied on the contact surface 654.
  • the base 910 includes a pad-facing surface 982 (or can alternatively be defined also as a wrist-facing surface) and an external surface 983 opposite to the pad-facing surface 982.
  • the wristband WB is received by the device such that it is sandwiched between the base surface 918, and specifically the wristband-engaging portions 977, and the pad-facing surface 982 of the base 910. Therefore, when the device 900 is fitted on a wristband WB, the pliable pad 902, and specifically the base surface 918 rests directly on the wristband WB.
  • the pad axis PA is defined as an axis parallel to one extending along the wristband WB
  • the pliable pad 902 comprises voids 920 or cutouts defined by the base surface 918 facing away from the wrist-bearing surface 915.
  • the voids 920 have a side cross-sectional shape resembling arched windows, with different sizes.
  • the size of the voids 920 decreases with respect to their distance from the center of the pliable pad along the pad axis PA. In other words, the further the void from the center of the pliable pad PA along the pad axis PA, the smaller the void.
  • These voids 920 extend from a plane PL defined by the wristband-engaging portions 977, which is typically a curved plane, toward the base surface 918 along an axis perpendicular to the plane PL.
  • the thinner central areas can bend and flex more easily, making the sensors more sensitive to small pressure changes. Meanwhile, the thicker edge areas keep the overall structure stable and durable.
  • Fig. 9E specifically illustrates a cross-sectional bottom view of the pliable pad 902, clearly showing the varying height profiles of the voids 920.
  • This cross-sectional view particularly exemplifies the distinction between the deeper middle sections 924 and the shallower edge sections 922 of each void.
  • the profile of these voids is essential to the functionality of all embodiments described in Fig. 10 and Fig.ll, as it enables the optimal flexibility characteristics required for accurate physiological measurements regardless of the sensor type employed.
  • the cut-out sections create a ribbed structure of two or more ribs 926 spaced apart by one or more voids. This structure allows the outer portions of the ribs to move away from one another when the pad bends around the wrist.
  • the device 900 is capable of moving along different positions of the wristband WB. This configuration enables freedom of movement of the device along the wrist and allows it to be placed in a desired location along the wrist of the subject wearing the device.
  • Figs. 11A-11C are schematic illustrations of different views of another embodiment of the device for measuring a physiological parameter.
  • the embodiment exemplified in Figs. 11A-11C differs from that of Figs. 9A- 9F by incorporating a hybrid configuration that comprises both strain gauge sensors 1108 and light-based sensors 1109 on the wrist-bearing surface 1115.
  • the strain gauge sensors 1108 are arranged along the pad axis PA.
  • Each light-based sensors 1109 is positioned between two adjacent strain gauge sensors 1130 and comprises a light source member 1142 and a light detector member 1144.
  • one of the members is located at a first half of the pliable pad 1102 and the other member (light source or detector) is positioned at a second half of the pliable pad 1102, wherein the first and second halves are defined based on the middle distance between a first side 1174 and a second side 1176 of the pliable pad 1102 along the light-based sensor axes SA
  • the light source members 1142 can be configured to transmit two different wavelengths, e.g. by including two different light sources, and the light detector members 1144 can be configured to detect the response of said two different wavelengths for enhanced physiological measurements.
  • the complementary sensor types allow for simultaneous mechanical (strain) and optical measurements of cardiovascular activity.
  • this embodiment of Figs. 11A-11C differs from that of Figs. 9A-9E by further comprising ECG (electrocardiogram) electrodes positioned on the device.
  • ECG electrocardiogram
  • Two first electrodes 1189 located on a wrist-facing face 1182 of the wristband-receiving portions 1179 of the base 1110 allowing a first contact of these two electrodes 1189 with a portion of the wrist of the subject when the device 1100 is worn on that wrist.
  • a second electrode 1193 is positioned on an external face 1183 ofthe body portion 1180 ofthe base 1110 facing away from the wrist. The second electrode 1193 serves to allow a second contact, e.g. by placing on it a finger of the opposite hand that is different than that wearing the device. .

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

La présente divulgation concerne un dispositif de mesure d'un paramètre physiologique d'un sujet. Le dispositif comprend un tampon souple associé à des capteurs, par exemple appliqués sur une surface de celui-ci. Les capteurs sont configurés pour mesurer des signaux qui indiquent une pression appliquée sur le tampon souple ou sur les capteurs. Le tampon souple est conçu de façon à pouvoir se plier de façon à se conformer à la forme du poignet du sujet avec lequel il vient en contact. En se conformant à la forme du poignet, le tampon souple augmente la sensibilité de mesure des capteurs. Les capteurs sont destinés à être positionnés sur le poignet du sujet de manière à pouvoir capter les déformations infimes de la peau dues au changement de débit sanguin dans les vaisseaux sanguins sous la peau, par exemple l'artère radiale. Afin de s'adapter au poignet, le tampon souple est accouplé à un élément de couplage qui est configuré pour permettre l'ajustement du dispositif au poignet du sujet et fixer le tampon souple à une position souhaitée pour obtenir les mesures.
PCT/IL2025/050296 2024-04-04 2025-04-03 Capteur de poignet pour mesurer un paramètre physiologique Pending WO2025210637A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IL31199324 2024-04-04
IL311993 2024-04-04
IL316638 2024-10-28
IL31663824 2024-10-28

Publications (1)

Publication Number Publication Date
WO2025210637A1 true WO2025210637A1 (fr) 2025-10-09

Family

ID=97266749

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2025/050296 Pending WO2025210637A1 (fr) 2024-04-04 2025-04-03 Capteur de poignet pour mesurer un paramètre physiologique

Country Status (1)

Country Link
WO (1) WO2025210637A1 (fr)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2348972B1 (fr) * 2009-08-28 2012-11-28 UP-MED GmbH Dispositif de mesure de la tension arterielle et procede de mesure de la tension arterielle chez un etre vivant
US20140296734A1 (en) * 2013-04-01 2014-10-02 Medsense Inc. Physiology signal sensing device
US20160287102A1 (en) * 2015-04-02 2016-10-06 Microsoft Technology Licensing, Llc Transducing pressure to a non-invasive pulse sensor
US20180279889A1 (en) * 2015-10-08 2018-10-04 Charmcare Co., Ltd. Wrist-worn blood pressure monitor
US20200272240A1 (en) * 2014-09-30 2020-08-27 Apple Inc. Motion and Gesture Input from a Wearable Device
US20210361237A1 (en) * 2018-05-10 2021-11-25 CardiacSense Ltd. A displacement sensor for use in measuring biological parameters
US20230270379A1 (en) * 2020-07-26 2023-08-31 CardiacSense Ltd. Device for measurement of physiological parameters through a skin contact surface
US20240156362A1 (en) * 2015-06-02 2024-05-16 CardiacSense Ltd. Sensing at least one biological parameter, e.g., heart rate or heart rate variability of a subject

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2348972B1 (fr) * 2009-08-28 2012-11-28 UP-MED GmbH Dispositif de mesure de la tension arterielle et procede de mesure de la tension arterielle chez un etre vivant
US20140296734A1 (en) * 2013-04-01 2014-10-02 Medsense Inc. Physiology signal sensing device
US20200272240A1 (en) * 2014-09-30 2020-08-27 Apple Inc. Motion and Gesture Input from a Wearable Device
US20160287102A1 (en) * 2015-04-02 2016-10-06 Microsoft Technology Licensing, Llc Transducing pressure to a non-invasive pulse sensor
US20240156362A1 (en) * 2015-06-02 2024-05-16 CardiacSense Ltd. Sensing at least one biological parameter, e.g., heart rate or heart rate variability of a subject
US20180279889A1 (en) * 2015-10-08 2018-10-04 Charmcare Co., Ltd. Wrist-worn blood pressure monitor
US20210361237A1 (en) * 2018-05-10 2021-11-25 CardiacSense Ltd. A displacement sensor for use in measuring biological parameters
US20230270379A1 (en) * 2020-07-26 2023-08-31 CardiacSense Ltd. Device for measurement of physiological parameters through a skin contact surface

Similar Documents

Publication Publication Date Title
JPWO1999040843A1 (ja) 生体情報計測装置
JP3475427B2 (ja) 生体情報計測装置
Rhee et al. Artifact-resistant, power-efficient design of finger-ring plethysmographic sensors. II. Prototyping and benchmarking
JP3722203B2 (ja) 脈波センサ
EP2291111B1 (fr) Surveillance de respiration sans contact d'un patient et détecteur optique pour une mesure de photopléthysmographie
US6210340B1 (en) Blood pulse measuring device, pulsation measuring device, and pressure measuring device
KR101033472B1 (ko) 동잡음 제거를 위한 광전용적맥파 계측용 센서모듈의 형태 및 방법
KR101954548B1 (ko) 진단 측정 기구
US20100305416A1 (en) Non-invasive pressured probing device
US20180078155A1 (en) Multi-model blood pressure estimation
US20070185393A1 (en) System for measuring vital signs using an optical module featuring a green light source
US20190069785A1 (en) Combined textile pressure and optic sensor
US20110124991A1 (en) System and method for mitigating interference in pulse oximetry
JP2002360530A (ja) 脈波センサ及び脈拍数検出装置
WO2013148753A1 (fr) Capteur et procédé pour la surveillance continue de l'état de santé
KR20020026570A (ko) 생명 징후 모니터링 장치
JP6293927B2 (ja) センサ
TW201438663A (zh) 生理訊號感測裝置
KR20180120183A (ko) 심혈관 진단을 위한 광학 측정 디바이스
JP2009082627A (ja) 生体情報測定装置
KR100681387B1 (ko) 맥파 검출 장치 및 검출 방법
JP3741147B2 (ja) 脈波センサ
KR102250188B1 (ko) 생체 정보 검출 장치
WO2025210637A1 (fr) Capteur de poignet pour mesurer un paramètre physiologique
EP4230131A1 (fr) Dispositif vestimentaire et procédé permettant de détecter un analyte dans un tissu d'un sujet humain ou animal

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 25782077

Country of ref document: EP

Kind code of ref document: A1