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WO2025207585A1 - Composition rodenticide activée par l'humidité sans danger pour l'environnement et système de distribution - Google Patents

Composition rodenticide activée par l'humidité sans danger pour l'environnement et système de distribution

Info

Publication number
WO2025207585A1
WO2025207585A1 PCT/US2025/021277 US2025021277W WO2025207585A1 WO 2025207585 A1 WO2025207585 A1 WO 2025207585A1 US 2025021277 W US2025021277 W US 2025021277W WO 2025207585 A1 WO2025207585 A1 WO 2025207585A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
weight
amount
bait
comprised
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2025/021277
Other languages
English (en)
Inventor
Josh MCCLOUD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2025207585A1 publication Critical patent/WO2025207585A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/06—Aluminium; Calcium; Magnesium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P11/00—Rodenticides

Definitions

  • This invention relates to fields of pest control and rodenticides.
  • this invention comprises a rodenticide composition of non-toxic ingredients, which are dry compressed into a bait tablet for killing rodents.
  • Said composition utilizes calcium sulfate (plaster of Paris) and other food-grade ingredients in a stable, solid form that remains inert until ingested by a rodent and is activated by moisture once in a rodent’s digestive tract.
  • rodent infestations pose serious public health and economic challenges. Such infestations are traditionally managed with chemical poisons (anticoagulants, neurotoxins, etc.) or mechanical traps.
  • rodents can develop resistance, and the poisons pose risks of accidental poisoning to non-target animals and children (secondary poisoning and environmental contamination are well-known issues). As such there is a need for rodenticides that are safer for other animals and the environment while still effectively controlling rodents.
  • Non-toxic and mechanical -kill rodenticides have been explored as alternatives to traditional chemical poisons.
  • Some existing products rely on dehydration as the primary mode of action, typically using food-grade ingredients designed to physiologically disrupt hydration pathways in rodents.
  • the present invention utilizes an entirely different composition and mechanism.
  • the formulation features a dry-compressed tablet comprised of calcium sulfate hemihydrate (plaster of Paris) that remains inert until ingested. Upon exposure to moisture inside the digestive tract, the calcium sulfate reacts to form a solid mass, creating a gastrointestinal blockage.
  • This physical obstruction mechanism can be complemented by the inclusion of sodium chloride (salt), a known desiccant, and additional drying agents such as silica and cellulose, which together promote systemic dehydration.
  • sodium chloride salt
  • desiccant a known desiccant
  • additional drying agents such as silica and cellulose
  • this invention represents the only known regulatory-compliant rodenticide specifically designed for use in commercial pest control settings.
  • the bait is manufactured in formats such as washer-style tablets and briquettes with central apertures, allowing secure deployment in standard bait stations.
  • This compatibility combined with shelfstable, tamper-resistant construction, makes it uniquely suited for professional use while maintaining regulatory compliance and environmental safety, thus eliminating secondary poisoning risk.
  • Prior art rodenticides generally fall into two categories: toxic chemical baits with significant safety and environmental risks, or non-toxic formulations that suffer from limitations in efficacy, stability, or field deployment.
  • Traditional rodenticides such as anticoagulants and neurotoxins, are effective but present hazards to non-target species and carry risks of secondary poisoning.
  • existing regulatory-compliant baits typically rely solely on food-based desiccants and require sustained ingestion over multiple days to achieve lethality, with limited mechanical action and vulnerability to moisture degradation.
  • FIG. 5 is a perspective view of a bait block embodiment of the invention; wherein said bait block can include a central hole for mounting on to a vertical rod for deployment in a prior art rodent bait station.
  • Dry Blending The powdered ingredients (plaster of Paris, salt (if used), sugars, any other attractants or fillers, etc.) are measured and combined in a suitable mixer or blender and milled. Care is taken to achieve a homogeneous mixture.
  • a two-step mixing is preferred: first, the large and medium-size particles (e g. plaster of Paris, granulated sugar, salt) are tumble-mixed. Second, the fine powders (powdered sugar, microcrystalline cellulose, etc.) are added and mixed further until uniform. This staggered approach helps prevent segregation and ensures even coating of the attractants onto the plaster of Paris particles.
  • Lubricants and Glidants The dry lubricant (zinc stearate) and glidant (silica) are added typically in the final phase of mixing. These are blended gently and briefly with the bulk powder — often for just a few minutes — to avoid over-milling. Overmixing with stearates can negatively affect tablet hardness by overly coating particles, so the process is controlled to achieve just enough distribution of lubricant. The resulting finished blend should have good flow (due to the silica) and should not clump or cake. At this stage, the powder is free-flowing and is an entirely dry blend - no liquids have been introduced at any point.
  • the dry powder blend is fed into a tablet press.
  • This can be a singlestation (eccentric) tablet press for small-scale production, or a rotary multi-station press for large-scale manufacturing.
  • the tablet press is fitted with tooling of the desired tablet size and shape to dry compress the composition to form a final composition bait.
  • the final composition bait is comprised of standard cylindrical tablets 200 as shown in FIG. 2 of about 2 cm diameter and 0.5-1 cm thickness are made, each weighing roughly 5-10 grams. This size is convenient for both rats and mice.
  • the final composition bait is comprised of cylindrical tablets 300 with a central hole 301 as shown in FIG.
  • This dry compression method of manufacture to form a final composition bait ensures that the plaster of Paris remains dehydrated and inactive during storage. Unlike some pelletizing methods, there is no addition of water, oils, or adhesives which could either activate the plaster of Paris or create a semi-moist tablet prone to molding.
  • the final composition bait tablets exit the press dry and ready-to-use. Each tablet is a concentrated dose containing a lethal amount of the composition ingredients for a rodent.
  • the process is highly scalable; for instance, a rotary press with multiple punches can produce tens of thousands of identical tablets per hour, each with minimal variation in weight (ensuring consistent efficacy).
  • the resulting final composition bait tablets are generally off-white to light tan in color, with a hard, smooth texture.
  • the final composition bait tablets are shelf-stable for extended periods. All composition ingredients are either inorganic minerals or dry foods, which means there are no volatile actives to degrade over time. Preliminary accelerated aging tests indicate that the final composition tablets resist crumbling and remain stable even after exposure to high humidity. The inclusion of silica and hydrophobic lubricant maintains the tablet’s integrity. As such, the final composition bait tablets demonstrate high suitability for warehouse storage and field deployment in non-ideal conditions.
  • the dry-compressed formulation demonstrated notable resilience against moderate environmental moisture, such as dew or nighttime humidity.
  • Protective excipients in the composition such as microcrystalline cellulose and colloidal silica — help prevent premature activation of the plaster of Paris.
  • the composition activates rapidly in the moist environment of the gastrointestinal tract, triggering the intended mechanical blockage and dehydration-based effects.
  • the formulation ensures that most of the plaster of Paris reaches the stomach still in a dry or only slightly activated state, which concentrates the composition’s action inside the rodent’ s gastrointestinal tract.
  • stomach tablet fragments encounter body moisture (gastric fluids or any water the rodent drinks shortly after feeding).
  • the plaster of Paris rapidly hydrates and expands, converting to gypsum. Because the tablet fragments are now dispersed in the stomach, the plaster of Paris can form a contoured cast that conforms to the interior stomach or intestinal wall. This results in a mechanical blockage of the pylorus of the stomach or the duodenum of the small intestine.
  • the rodent typically experiences discomfort and a feeling of fullness, causing it to cease consumption of any further bait, which is advantageous to prevent excessive bait consumption.
  • sodium chloride dissolves readily in the stomach contents, being absorbed into the bloodstream and drawing water out of the rodent’s tissues (intensifying dehydration).
  • the salt also makes the rodent extremely thirsty. If the rodent drinks water to quench their thirst, the increased water in the digestive tract in turn reacts with any remaining plaster of Paris, thus enhancing the mechanical blockage of the plaster of Paris. Meanwhile, silica particles and any cellulose in the final composition absorb fluids in the stomach and gut, further desiccating the environment inside the rodent.
  • organs begin to dry out or fail (as observed in histopathology data, extreme hemoconcentration and kidney failure can occur), and the hardened mass in the stomach/intestine prevents any relief.
  • rodents cannot vomit, so they are unable to expel the material. Death often follows relatively quickly - in some cases within just a few hours for mice, and within a day for larger rats, depending on the quantity consumed.
  • Another significant benefit of this mode of action is that it is humane and minimizes suffering time compared to sub-lethal poisoning.
  • the rodent typically slips into a lethargic state due to dehydration and shock before expiring, and it is less likely to experience prolonged pain as can happen with anticoagulants (which can take days of internal bleeding).
  • Another benefit is the lack of secondary toxicity: the expired carcass contains essentially just hardened gypsum and naturally occurring substances (salt, sugars). Predators or scavengers consuming the dead rodent will not be poisoned.
  • the gypsum mass will not be digested by a predator; it remains like a stone or bone in the stomach, which can be regurgitated or passed without harm. This greatly reduces the ecological impact and disposal concerns of using the composition.
  • Example 1 Formulation and Manufacturing of Dry-Compressed Bait Tablets.
  • a preferred batch of rodenticide tablets was prepared with the following formulation (percentages by weight):
  • Microcrystalline Cellulose (binding agent) All ingredients above are food-grade or regulatory-exempt substances.
  • the powdered sugar and peanut butter powder are optional in this example; they were included to demonstrate a potential variant with additional bulk and flavor.
  • any enticing dry food-grade material could be substituted as an attractant.
  • granulated sugar could be utilized in conjunction with powdered sugar to provide added sweetness and enhance material matrix.
  • the above percentages by weight could be altered while still maintaining the composition’s effectiveness.
  • the plaster of Paris, sodium chloride, edible attractants, and microcrystalline cellulose, colloidal silica were loaded into a disc mill or grinding mill and tumbled for 10 minutes to achieve a uniform powder wherein particles were 300 pm or less.
  • silicon dioxide and zinc stearate were added and the blender was run for an additional 3 minutes to distribute the fine excipients without over-coating.
  • the resulting powder blend mixture showed excellent flowability through a funnel with no clumping.
  • the resulting powder blend should pass through a 50-mesh sieve (less than 300 pm). Particles over 300 pm should be re-milled to achieve a homogenous powder blend.
  • the powder blend was fed into a laboratory rotary tablet press fitted with 1/2-inch (12.7 mm) flat-faced round punches. Tablets 200 weighing approximately 5.0 grams each were pressed. Compression force was adjusted to about 2 tons, yielding tablets 200 with a hardness of 30 N or above (as measured by a tablet hardness tester), which was found to be hard enough to resist breakage but be easily gnawed by rodents. The tablets had a smooth texture and did not cap or crack upon ejection. No sticking to tooling was observed, confirming adequate lubrication. Approximately 1000 tablets 200 were produced in this batch.
  • the tablets were stored in unsealed containers at ambient laboratory conditions (-50-60% relative humidity) for two weeks. They remained dry and intact, with no signs of surface hydration or softening. Meanwhile, tablets left on a shelf did not change over weeks, illustrating the stability in the absence of liquid water.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Dentistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention divulgue un rodenticide conforme à la réglementation et sans danger pour l'environnement et un procédé de fabrication. L'invention utilise des ingrédients sans danger pour l'environnement comprenant du sulfate de calcium hémihydraté (plâtre de Paris), du chlorure de sodium, des attractifs comestibles et des lubrifiants secs. Ceux-ci sont comprimés à sec en un comprimé stable activé par l'humidité qui reste inerte dans les conditions ambiantes et devient létal lors de l'ingestion par un rongeur. Une fois consommé, l'humidité dans le tube digestif déclenche une obstruction gastro-intestinale et une déshydratation systémique, conduisant à une mortalité rapide sans risque d'empoisonnement secondaire. Le procédé de fabrication par compression à sec permet une production évolutive et stable au stockage compatible avec une utilisation commerciale dans le domaine de la lutte contre les nuisibles. L'appât peut être produit sous plusieurs formats à utilisation sécurisée, y compris sous forme de comprimés de type rondelle, de blocs briquettes et de comprimés appâts à disperser, pour une utilisation sûre et flexible dans des stations d'appât inviolables ou en placement direct.
PCT/US2025/021277 2024-03-25 2025-03-25 Composition rodenticide activée par l'humidité sans danger pour l'environnement et système de distribution Pending WO2025207585A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202463569618P 2024-03-25 2024-03-25
US63/569,618 2024-03-25

Publications (1)

Publication Number Publication Date
WO2025207585A1 true WO2025207585A1 (fr) 2025-10-02

Family

ID=97220065

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2025/021277 Pending WO2025207585A1 (fr) 2024-03-25 2025-03-25 Composition rodenticide activée par l'humidité sans danger pour l'environnement et système de distribution

Country Status (1)

Country Link
WO (1) WO2025207585A1 (fr)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001010845A1 (fr) * 1999-08-10 2001-02-15 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Nouvelles diketo-piperazines
WO2004062362A2 (fr) * 2003-01-14 2004-07-29 Loichinger, Wolfgang Composition particulaire pour supprimer des rongeurs indésirables
US20050196487A1 (en) * 2002-11-06 2005-09-08 Barra Jerome Gum base composition
US20090163598A1 (en) * 2007-12-21 2009-06-25 3M Innovative Properties Company Antimicrobial cellulose sponge and method of making
US20100029486A1 (en) * 2008-07-31 2010-02-04 Michael Dean Willis Extended release tablet and method for making and using same
EP2742801A2 (fr) * 2012-12-12 2014-06-18 Dr. Tezza S.r.l. Formulations rodenticides sensiblement atoxiques sous forme de pâte fraîche, de pastilles ou bloc de paraffine, actives au moyen de l'occlusion intestinale
CN109479845A (zh) * 2018-12-10 2019-03-19 安徽三分钟钓具有限公司 一种新型环保钓鱼饵料及其制备方法
US20200129437A1 (en) * 2017-06-23 2020-04-30 Basf Se Dry-binders for tablets based on polyethylene glycol-polyvinyl alcohol graft polymers, the production and use thereof
US20220062287A1 (en) * 2019-02-20 2022-03-03 Zoetis Services Llc Palatable formulations
US20220218717A1 (en) * 2019-05-21 2022-07-14 Cuckos Pharmaceutical Private Limited Process for manufacturing soft chewable free flowing granules and companion animal products thereof

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001010845A1 (fr) * 1999-08-10 2001-02-15 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Nouvelles diketo-piperazines
US20050196487A1 (en) * 2002-11-06 2005-09-08 Barra Jerome Gum base composition
WO2004062362A2 (fr) * 2003-01-14 2004-07-29 Loichinger, Wolfgang Composition particulaire pour supprimer des rongeurs indésirables
US20090163598A1 (en) * 2007-12-21 2009-06-25 3M Innovative Properties Company Antimicrobial cellulose sponge and method of making
US20100029486A1 (en) * 2008-07-31 2010-02-04 Michael Dean Willis Extended release tablet and method for making and using same
EP2742801A2 (fr) * 2012-12-12 2014-06-18 Dr. Tezza S.r.l. Formulations rodenticides sensiblement atoxiques sous forme de pâte fraîche, de pastilles ou bloc de paraffine, actives au moyen de l'occlusion intestinale
US20200129437A1 (en) * 2017-06-23 2020-04-30 Basf Se Dry-binders for tablets based on polyethylene glycol-polyvinyl alcohol graft polymers, the production and use thereof
CN109479845A (zh) * 2018-12-10 2019-03-19 安徽三分钟钓具有限公司 一种新型环保钓鱼饵料及其制备方法
US20220062287A1 (en) * 2019-02-20 2022-03-03 Zoetis Services Llc Palatable formulations
US20220218717A1 (en) * 2019-05-21 2022-07-14 Cuckos Pharmaceutical Private Limited Process for manufacturing soft chewable free flowing granules and companion animal products thereof

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