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WO2025243411A1 - Source de lumière à bande de nombre d'onde double - Google Patents

Source de lumière à bande de nombre d'onde double

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Publication number
WO2025243411A1
WO2025243411A1 PCT/JP2024/018751 JP2024018751W WO2025243411A1 WO 2025243411 A1 WO2025243411 A1 WO 2025243411A1 JP 2024018751 W JP2024018751 W JP 2024018751W WO 2025243411 A1 WO2025243411 A1 WO 2025243411A1
Authority
WO
WIPO (PCT)
Prior art keywords
optical pulse
pulse train
optical
light source
laser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/JP2024/018751
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English (en)
Japanese (ja)
Inventor
茂雄 石橋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTT Inc
NTT Inc USA
Original Assignee
Nippon Telegraph and Telephone Corp
NTT Inc USA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Telegraph and Telephone Corp, NTT Inc USA filed Critical Nippon Telegraph and Telephone Corp
Priority to PCT/JP2024/018751 priority Critical patent/WO2025243411A1/fr
Publication of WO2025243411A1 publication Critical patent/WO2025243411A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G02—OPTICS
    • G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
    • G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
    • G02F1/35—Non-linear optics
    • G02F1/37—Non-linear optics for second-harmonic generation

Definitions

  • This disclosure relates to a light source used in a coherent Raman scattering (CRS) microscope that detects stimulated Raman scattering (SRS) and coherent anti-Stokes Raman scattering (CARS), primarily targeting cells and biological tissues.
  • CRS coherent Raman scattering
  • SRS stimulated Raman scattering
  • CARS coherent anti-Stokes Raman scattering
  • a widely used research method in medical and life sciences is to attach fluorescent dyes to specific molecules within cells or biological tissues and display the distribution of those molecules in fluorescence microscope images.
  • the emission bands of many fluorescent dyes are broad, limiting the number of molecules that can be observed simultaneously.
  • fluorescent dyes require relatively large molecular sizes, and attaching them to small molecules alters the properties of the molecules, making them unsuitable for observing small molecules.
  • Raman tags solve these problems, with alkynes (single triple bond) or polyynes (alternating single and triple bonds) currently being developed (see non-patent literature 1 and 2). It is expected that small molecule tags will make it possible to observe up to 20 different molecules simultaneously, compared to fluorescent dyes.
  • Raman scattering spectroscopy is widely used in many academic fields, including chemistry, biology, medicine, pharmacy, agriculture, and physics, as a means of obtaining vibrational information on molecules, crystals, and amorphous structures. It is also widely used in medicine and industry.
  • Spontaneous Raman scattering is a phenomenon that produces scattered light whose frequency is shifted by the frequency of molecular or lattice vibrations relative to the incident light. Because this scattered light has very little power compared to the original incident light power, a light source with high incident power is required to obtain scattered light measurable by a detector. However, most measurement samples have an upper limit to the average power per unit area that can be irradiated, and exceeding this limit will result in alteration or destruction.
  • the scattered light is weak, and significantly long measurement times are required to obtain a signal with a high signal-to-noise ratio.
  • CRS is a nonlinear optical process using a light source with high instantaneous power. Therefore, compared to spontaneous Raman scattering, the power of Raman scattered light is significantly stronger when using a light source with the same level of average power, resulting in shorter measurement times.
  • Alkyne and polyyne Raman tags have peaks near 2000-2300 cm -1 , a wavenumber where other organic molecules in vivo do not exhibit peaks, making them suitable for observation.
  • pulsed light with a time width of several picoseconds in two wavelength ranges, near 800-850 nm and near 1030 nm, has traditionally been used.
  • the equipment used is a Ti-doped sapphire laser in the 800 nm band and a Yb-doped glass fiber laser in the 1000 nm band.
  • FIG. 1 shows the configuration of a conventional laser light source for an SRS microscope, as described in Non-Patent Documents 3 and 4.
  • the conventional light source shown in FIG. 1 includes a Ti-doped sapphire picosecond pulse laser 101 with a wavelength in the 800 nm band and a Yb-doped glass picosecond pulse laser 104 with a wavelength in the 1000 nm band.
  • the Ti-doped sapphire picosecond pulse laser 101 generates a picosecond optical pulse train 103 with a repetition rate of 76 MHz.
  • the Yb-doped glass picosecond pulse laser 104 generates a picosecond optical pulse train 105 with a repetition rate of 38 MHz.
  • the two picosecond pulse lasers are coupled via an electrical signal path 111, and their pulse timing is synchronized.
  • the two pulsed beams are combined by a dichroic mirror 112 and input to a microscope 102 via the same optical path.
  • CRS measurement is performed by simultaneously irradiating the two pulsed beams onto a sample to be measured.
  • the Ti-doped sapphire picosecond pulse laser 101 switches its oscillation wavelength between 790 nm and 843 nm, covering both the wavenumber range of 2000-2300 cm -1 and the high wavenumber range of 2800-3100 cm -1 of Raman tags.
  • the Yb-doped glass picosecond pulse laser 104 sweeps its wavelength between 1014 nm and 1046 nm, enabling measurement of a wavenumber band of 300 cm -1 .
  • Figure 2 shows an energy diagram of the molecules of a sample to be measured when measuring SRS.
  • the pump light 106 angular frequency ⁇ 1
  • the Stokes light 107 angular frequency ⁇ 2
  • Figure 2 shows an energy diagram of the molecules of a sample to be measured when measuring SRS.
  • the pump light 106 angular frequency ⁇ 1
  • the Stokes light 107 angular frequency ⁇ 2
  • Figure 2 shows an energy diagram of the molecules of a sample to be measured when measuring SRS.
  • This disclosure was made in consideration of the above-mentioned problems, and its purpose is to provide a light source that uses only light with wavelengths of 1000 nm or longer and that scatters less in living organisms than conventional technology.
  • a light source includes a mode-locked laser that outputs two types of optical pulse trains with different center wavelengths ⁇ s, a first optical element that splits the optical pulse train into two optical pulse trains, two steady-state oscillation solid-state lasers that output continuous light with two different oscillation wavelengths ⁇ p corresponding to the two types of optical pulse trains with different center wavelengths ⁇ s, and two optical multiplexers that combine one of the two split optical pulse trains with one of the two continuous light with two different oscillation wavelengths ⁇ p corresponding to the center wavelength ⁇ s of one of the optical pulse trains.
  • a light source includes a mode-locked laser that outputs two types of optical pulse trains having different center wavelengths ⁇ s, a first optical element that splits the optical pulse train into two optical pulse trains, two steady-state oscillation solid-state lasers that output continuous light of two different oscillation wavelengths ⁇ p corresponding to the two types of optical pulse trains having different center wavelengths ⁇ s, a second optical element that combines one of the two split optical pulse trains with one of the two continuous light of two different oscillation wavelengths ⁇ p corresponding to the center wavelength ⁇ s of one of the optical pulse trains, and a difference frequency generation conversion light that converts the combined light into a picosecond optical pulse train with a center wavelength ⁇ c.
  • FIG. 1 is a schematic diagram showing a light source for a conventional CRS microscope.
  • FIG. 2 is a diagram showing an energy diagram of a molecule to be measured in stimulated Raman scattering (SRS) that measures multiple wavenumbers.
  • FIG. 3 is a diagram showing an energy diagram of a molecule to be measured in coherent anti-Stokes Raman scattering (CARS) that measures multiple wavenumbers.
  • FIG. 4 is a first schematic diagram illustrating a light source for a CRS microscope according to an embodiment of the present disclosure.
  • FIG. 5 is a second schematic diagram illustrating a light source for a CRS microscope according to an embodiment of the present disclosure.
  • the light sources 400 and 500 of this embodiment can be used as a dual-wavelength band light source when observing both the wavelength range of 2000-2300 cm and the high wavelength range of 2800-3100 cm in a CRS microscope.
  • the light source of this embodiment can be used for both SRS and CARS as nonlinear optical processes in a CRS microscope.
  • Non-Patent Document 5 when detecting the pump light 106 (angular frequency ⁇ 1 ) or the Stokes light 107 (angular frequency ⁇ 2 ) in the energy diagram shown in Figure 2, it is possible to use a lock-in detection system with several tens of multi-channels (see Non-Patent Document 5).
  • One of the light sources is narrowband (approximately 5 cm -1 or less) and the other is broadband (approximately 300 cm -1 or more), and one of the light sources needs to have a wavelength switching function so that it can be changed to measure between wavenumbers around 2000-2300 cm -1 and wavenumbers around 2800-3100 cm -1 .
  • FIG. 3 shows an energy diagram of a sample molecule to be measured when measuring CARS.
  • CARS light 109 angular frequency ⁇ CARS
  • the light source that serves both pump light 106 and probe light 108 is narrowband (approximately 5 cm ⁇ 1 or less)
  • the Stokes light 107 is broadband (approximately 300 cm ⁇ 1 or more).
  • One of the light sources has a wavelength switching function so that it can be switched between measurements around wavenumbers of 2000-2300 cm ⁇ 1 and measurements around wavenumbers of 2800-3100 cm ⁇ 1 .
  • the light source of this embodiment can be used for both SRS and CARS.
  • SRS it is necessary to modulate the correlation between the pump light 106 (angular frequency ⁇ 1 ) and the Stokes light 107 (angular frequency ⁇ 2 ) when they are incident on the measurement sample.
  • the light source 400 includes a mode-locked laser 1 capable of switching between and outputting two types of femtosecond optical pulse trains having different center wavelengths ⁇ s, two continuous wave (CW) solid-state lasers 3 and 4 that output continuous light with different oscillation wavelengths ⁇ p and steady powers, two second-order nonlinear optical elements 8 and 9 for generating a difference frequency corresponding to the difference frequency between the switched femtosecond optical pulse train with the center wavelength ⁇ s and the continuous light with the corresponding oscillation wavelength ⁇ p, and an optical amplifier 15 that amplifies the difference frequency generated optical pulse train output from the second-order nonlinear optical elements.
  • a mode-locked laser 1 capable of switching between and outputting two types of femtosecond optical pulse trains having different center wavelengths ⁇ s
  • two continuous wave (CW) solid-state lasers 3 and 4 that output continuous light with different oscillation wavelengths ⁇ p and steady powers
  • two second-order nonlinear optical elements 8 and 9 for generating a difference frequency corresponding to the difference frequency between
  • the mode-locked laser 1 is a Cr 4+ :YAG single crystal fiber mode-locked laser whose central wavelength ⁇ s can be switched between a predetermined wavelength, in this embodiment, around 1380 nm and around 1550 nm (see Non-Patent Documents 7 and 8).
  • the mode-locked laser 1 may have an internal switching mechanism for a set of a dispersion compensation medium and a saturable absorber mirror to enable the central wavelength ⁇ s to be changed.
  • the mode-locked laser 1 includes a laser resonator made of a Cr 4+ :YAG single crystal fiber, a dispersion compensation medium (specifically, a quartz glass rod and a dispersion compensation mirror), and a saturable absorber mirror (specifically, a semiconductor saturable absorber mirror).
  • the mode-locked laser 1 is an external resonator type laser including a single crystal fiber waveguide and a spatial optical system, and an optical path switching mirror is installed midway along the optical path of the spatial optical system.
  • a saturable absorber mirror is installed on one optical path from the switching mirror to generate pulses with a center wavelength of, for example, 1380 nm.
  • a dispersion compensation mirror and a saturable absorber mirror are installed on the other optical path from the switching mirror to generate pulses with a center wavelength of, for example, 1550 nm.
  • the switching mirror can be switched by an electrical signal as needed.
  • the laser configuration is similar to that of the Cr 4+ :YAG single crystal fiber laser described in Patent Document 1.
  • the oscillation pulse width of the Cr 4+ :YAG single crystal fiber mode-locked laser 1 can be set to 50 fs or less, and is about 40 fs in this embodiment.
  • This pulse light has an energy band roughly corresponding to a wavenumber width of 300 cm ⁇ 1 .
  • the femtosecond optical pulse train 5 output from the mode-locked laser 1 is split into two optical pulse trains by a first optical element 10 formed on the output side, such as a semi-transparent mirror or beam splitter.
  • One of the optical pulse trains is used to generate a difference frequency, and the generated difference frequency is amplified by an optical amplifier to become pump light.
  • the pulse width of the other optical pulse train is adjusted to become Stokes light.
  • both optical pulse trains (pump light and Stokes light) are combined and output to the CRS microscope 2.
  • two steady-state solid-state lasers 3 and 4 with different oscillation wavelengths ⁇ p and two corresponding second-order nonlinear optical elements 8 and 9 for difference frequency generation are used.
  • the steady-state solid-state lasers 3 and 4 and the second-order nonlinear optical elements 8 and 9 are explained below.
  • steady-state solid-state laser In order to convert femtosecond optical pulse trains 5 near 1380 nm and 1550 nm into pump light of the same center wavelength ⁇ c (1052 nm in this embodiment), two steady-state oscillation solid-state lasers 3, 4 are provided, each corresponding to a respective center wavelength ⁇ s. Of the two steady-state oscillation solid-state lasers 3, 4, one (first) steady-state oscillation solid-state laser 3 outputs continuous light 6 with an oscillation wavelength ⁇ p of 597 nm, and the other (second) steady-state oscillation solid-state laser 4 outputs continuous light 7 with an oscillation wavelength ⁇ p of 627 nm. In this embodiment, a diode-pumped solid-state (DPSS) laser is used as the steady-state oscillation solid-state laser.
  • DPSS diode-pumped solid-state
  • Continuous light beams 6 and 7 output from the steady-state solid-state lasers 3 and 4 are combined with the femtosecond optical pulse train 5 output from the mode-locked laser 1 to generate a difference frequency optical pulse train.
  • Each steady-state solid-state laser 3 and 4 is equipped with a mechanical shutter configured to selectively output continuous light corresponding to the center wavelength ⁇ s of the femtosecond optical pulse train 5 output from the mode-locked laser 1.
  • two second optical elements 11 and 12 are arranged on the output side of the steady-state oscillation solid-state lasers 3 and 4 to combine the continuous light and the femtosecond optical pulse train 5 output from the mode-locked laser 1 and input the combined light to the second-order nonlinear optical elements 8 and 9.
  • a dichroic mirror can be used for optical element 11, and an optical path switching mirror can be used for optical element 12.
  • the femtosecond optical pulse train 5 When the femtosecond optical pulse train 5 has a center wavelength of 1380 nm, it passes through the optical element 12 located on the output side of the second steady-state oscillation solid-state laser 4. The transmitted femtosecond optical pulse train 5 is then multiplexed with continuous light 6 having a wavelength of 597 nm by the optical element 11 located on the output side of the first steady-state oscillation solid-state laser 3, and is then coaxially input into the first second-order nonlinear optical element 8.
  • the optical element 12 arranged on the output side of the second steady-state solid-state laser 4 is switched to reflecting the femtosecond optical pulse train 5.
  • the reflected femtosecond optical pulse train 5 is combined with continuous light 7 having a wavelength of 627 nm and input coaxially to the second second-order nonlinear optical element 9.
  • the difference frequency optical pulse train 6 which is obtained by combining the femtosecond optical pulse train 5 and the continuous light from the first steady-state solid-state laser 3, is incident on a first second-order nonlinear optical element 8 and can be converted into a difference frequency generated converted optical pulse train 13 having a center wavelength of 1052 nm as a difference frequency.
  • the first second-order nonlinear optical element 8 is generally made of poled lithium niobate (PPLN), but is not limited to PPLN. In this case, the pulse width of the difference frequency generated converted optical pulse train 13 is 2.5 ps.
  • the second second-order nonlinear optical element 9 generally uses poled lithium niobate (PPLN), but is not limited to PPLN.
  • the pulse width of the difference frequency converted optical pulse train 13 is 2.5 ps. Note that the same method as in Patent Document 2 is used to set the inversion period and crystal length of the PPLN to perform appropriate difference frequency generation.
  • the central wavelength ⁇ s of the femtosecond optical pulse train 5 the oscillation wavelength ⁇ p of the steady-state oscillation solid-state lasers 3 and 4, and the central wavelength ⁇ c of the difference frequency generation converted optical pulse trains 13 and 14 are numerical values that satisfy the following formula 1.
  • the difference frequency generation converted optical pulse train 14 output from the second second-order nonlinear optical element 9 passes through a total reflection mirror 20 and reaches an optical path switching mirror 22.
  • the optical path switching mirror 22 transmits the femtosecond optical pulse train 5 when it has a center wavelength of 1380 nm, and reflects it when it has a center wavelength of 1550 nm, emitting the difference frequency generation converted optical pulse train 13 or 14 from the same position and in the same direction in either case.
  • the difference frequency generation converted optical pulse train 13 or 14 is amplified by a Yb glass fiber optical amplifier 15 to an average output of approximately 10 mW to 1 W, and is input to the microscope 2 as pump light 17.
  • the other optical pulse train which is split by the first optical element 10 from the femtosecond optical pulse train 5 output from the mode-locked laser 1, is chirped by a dispersion medium 16 arranged in the direction of propagation of the mode-locked laser 1 and converted into Stokes light 18 with a pulse width of approximately 2.5 ps.
  • the Stokes light 18 passes through a total reflection mirror 21 arranged in the optical path, is combined with the pump light 17 by a dichroic mirror 19, and is output coaxially toward the CRS microscope 2.
  • an appropriate adjustment mechanism may be installed in the optical path to match the timing of the pulses in the pump light 17 and Stokes light 18.
  • the light source described in embodiment 1 uses a CRS light source with a wavelength of 1000 nm or more that is compatible with measurements in both the Raman tag wavenumber range and the high wavenumber range, enabling highly sensitive measurements with minimal scattering in living organisms.
  • FIG. 5 shows a measurement system including a light source 500 in one embodiment of the present disclosure, with the light source 500 in this embodiment being shown within a dashed line.
  • the difference from embodiment 1 shown in Figure 4 is the difference frequency generation section, in which the second-order nonlinear optical element 8 employs a polarization-inverted structure (a superlattice structure in this embodiment) designed to achieve quasi-phase matching whether the center wavelength ⁇ s of the femtosecond optical pulse train 5 from the mode-locked laser 1 is 1380 nm or 1550 nm.
  • the polarization-inverted structure of the second-order nonlinear optical element 8 used in embodiment 2 is the same as the quasi-periodic structure disclosed in Non-Patent Documents 9 and 10.
  • the continuous light 6 from the first steady-state oscillation solid-state laser 3 with a wavelength of 597 nm passes through the dichroic mirror 23, and is combined by the second optical element 11 with one of the optical pulse trains branched by the first optical element 10 formed on the output side of the mode-locked laser 1, and then input to the second-order nonlinear optical element 8.
  • the continuous light 7 from the second steady-state oscillation solid-state laser 4 with a wavelength of 627 nm is reflected by the dichroic mirror 23, and is combined by the second optical element 11 with one of the optical pulse trains branched by the first optical element 10 formed on the output side of the mode-locked laser 1, and then input to the second-order nonlinear optical element 8.
  • the femtosecond optical pulse train 5 can be converted into a difference frequency generated converted optical pulse train 13 with a center wavelength of 1052 nm in both cases where the center wavelength is 1380 nm or 1550 nm. Therefore, there is no need to selectively move the switching mirror as described above, and a light source that can produce a more stable output than embodiment 1 can be expected.
  • a light source configured by combining a Cr 4+ : YAG single crystal fiber mode-locked laser 1 and a Yb-glass fiber optical amplifier 15 has been shown as an example.
  • the mode-locked laser 1 can be any of the following crystals, ceramics, glass doped with a rare earth ion selected from Yb, Er, Nd, Tm, and Ho, or YVO 4 doped with a rare earth ion selected from Yb, Er, Nd, Tm, and Ho, or a semiconductor crystal as a laser medium, as required.
  • the laser medium of the mode-locked laser 1 may be in the form of a rod, a disk, or a fiber.
  • the pulse train output from the mode-locked laser 1 has a pulse width of about 40 fs, this is just an example, and the laser medium may have a shorter pulse width or a longer pulse width, including a pulse width of 1 picosecond or more.
  • the optical amplifier 15 can be either a glass fiber optical amplifier doped with one rare earth ion selected from Yb, Er, Nd, Tm, Ho, etc., or a single crystal fiber optical amplifier doped with one rare earth ion selected from Yb, Er, Nd, Tm, Ho, etc., as needed.
  • the steady-state oscillation solid-state lasers 3 and 4 can be one steady-state oscillation solid-state laser selected from a glass fiber laser, a bulk-shaped single crystal laser, a bulk-shaped ceramic laser, a waveguide-type single crystal laser, a waveguide-type ceramic laser, or a semiconductor laser.
  • the second-order nonlinear optical element 8 is described as being made of PPLN, but it can also be made of other materials such as periodically poled lithium tantalate and periodically poled KTP.

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  • Physics & Mathematics (AREA)
  • Nonlinear Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)

Abstract

La présente divulgation concerne une source de lumière pour un microscope à diffusion Raman cohérente à des longueurs d'onde de 1000 nm ou plus avec une faible diffusion dans un corps vivant, ladite source de lumière prenant en charge des mesures à la fois dans une plage de nombres d'ondes d'étiquette Raman et une plage de nombres d'ondes élevée.　Spécifiquement, la présente divulgation concerne une source de lumière (400) comprenant : un laser à mode verrouillé (1) ayant une fonction pour délivrer en sortie deux trains d'impulsions optiques différents ayant différentes longueurs d'onde centrales λs ; deux lasers à semi-conducteurs oscillants à l'état stable (3, 4) qui délivrent en sortie une lumière continue de deux longueurs d'onde d'oscillation différentes λp correspondant aux deux trains d'impulsions optiques différents ayant différentes longueurs d'onde centrales λs ; et au moins deux éléments optiques non linéaires de second ordre (8, 9) qui convertissent la lumière combinée en un train d'impulsions optiques picoseconde ayant une longueur d'onde centrale λc, c'est-à-dire un train d'impulsions optiques de conversion de génération de différence de fréquence. Les longueurs d'onde centrales λs des trains d'impulsions optiques, les longueurs d'onde d'oscillation λp des lasers à semi-conducteurs oscillants à l'état stable, et la longueur d'onde centrale λc du train d'impulsions optiques de conversion de génération de différence de fréquence satisfont la relation 1/λc = 1/λp − 1/λs.
PCT/JP2024/018751 2024-05-21 2024-05-21 Source de lumière à bande de nombre d'onde double Pending WO2025243411A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2024/018751 WO2025243411A1 (fr) 2024-05-21 2024-05-21 Source de lumière à bande de nombre d'onde double

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2024/018751 WO2025243411A1 (fr) 2024-05-21 2024-05-21 Source de lumière à bande de nombre d'onde double

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007052288A (ja) * 2005-08-18 2007-03-01 Advantest Corp 光生成装置および該装置を備えたテラヘルツ光生成装置
JP2008028380A (ja) * 2006-06-22 2008-02-07 Matsushita Electric Ind Co Ltd レーザ光源装置及び画像表示装置
EP2982947A1 (fr) * 2014-08-08 2016-02-10 Baden-Württemberg Stiftung gGmbH Systèmes et procédés de spectroscopie Raman cohérente
WO2022009436A1 (fr) * 2020-07-10 2022-01-13 日本電信電話株式会社 Source de lumière pour microscope optique non linéaire multimodal
WO2023243052A1 (fr) * 2022-06-16 2023-12-21 日本電信電話株式会社 Source de lumière

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007052288A (ja) * 2005-08-18 2007-03-01 Advantest Corp 光生成装置および該装置を備えたテラヘルツ光生成装置
JP2008028380A (ja) * 2006-06-22 2008-02-07 Matsushita Electric Ind Co Ltd レーザ光源装置及び画像表示装置
EP2982947A1 (fr) * 2014-08-08 2016-02-10 Baden-Württemberg Stiftung gGmbH Systèmes et procédés de spectroscopie Raman cohérente
WO2022009436A1 (fr) * 2020-07-10 2022-01-13 日本電信電話株式会社 Source de lumière pour microscope optique non linéaire multimodal
WO2023243052A1 (fr) * 2022-06-16 2023-12-21 日本電信電話株式会社 Source de lumière

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