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WO2025137392A1 - Compositions de conditionnement, compositions de lavage et leurs procédés d'utilisation - Google Patents

Compositions de conditionnement, compositions de lavage et leurs procédés d'utilisation Download PDF

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Publication number
WO2025137392A1
WO2025137392A1 PCT/US2024/061181 US2024061181W WO2025137392A1 WO 2025137392 A1 WO2025137392 A1 WO 2025137392A1 US 2024061181 W US2024061181 W US 2024061181W WO 2025137392 A1 WO2025137392 A1 WO 2025137392A1
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WO
WIPO (PCT)
Prior art keywords
certain embodiments
cleanser
conditioner
total weight
chloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/061181
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English (en)
Inventor
Rita Jaky EL-KHOURI
Karis STALEY
Meagan SCHLAPP
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K18 Inc
Original Assignee
K18 Inc
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Filing date
Publication date
Application filed by K18 Inc filed Critical K18 Inc
Publication of WO2025137392A1 publication Critical patent/WO2025137392A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/044—Suspensions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Definitions

  • BACKGROUND [0002] Formulating hair conditioners involves navigating challenges such as achieving the right combination of ingredients for optimal performance, maintaining product stability, ensuring regulatory compliance, addressing consumer preferences for texture and scent, and balancing cost considerations. Additional complexities include preserving the product effectively, meeting environmental sustainability goals, and conducting thorough testing for safety and quality assurance.
  • a cleanser comprising: a hair conditioner.
  • the hair conditioner comprises panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof.
  • the hair conditioner is present in the cleanser at about 0.01% (%w/w) to about 10% (%w/w) of the cleanser.
  • the cleanser comprises a skin conditioner.
  • the skin conditioner is present in the cleanser at about 0.01% (%w/w) to about 5% (%w/w) of the cleanser.
  • the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof.
  • the cleanser comprises a cleansing agent.
  • the total concentration (%w/w) of the cleansing agent is about 5% (%w/w) to about 25% (%w/w).
  • WSGR Docket No.: 63230-729.601 [0006]
  • the one cleansing agent is a surfactant.
  • the surfactant comprises an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof.
  • the surfactant comprises the anionic surfactant.
  • the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylenesulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylenesulfonate, TEA-dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof.
  • the surfactant comprises the amphoteric surfactant.
  • the amphoteric surfactant comprises cocamindopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof.
  • the cleanser comprises an excipient.
  • the excipient is a cosmetically acceptable excipient.
  • the excipient is a dermatologically acceptable excipient.
  • the excipient is present in the cleanser at about 0.1% (%w/w) to about 30% (%w/w) of the cleanser.
  • the excipient comprises a humectant.
  • the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof.
  • the humectant is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser.
  • the excipient comprises a chelating agent.
  • the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L- WSGR Docket No.: 63230-729.601 arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof.
  • the buffer is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser.
  • the excipient comprises a preservative.
  • the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof.
  • the preservative is present in the cleanser at about 0.01% (%w/w) to about 0.1% (%w/w) of the cleanser.
  • the cleanser comprises a solvent.
  • the concentration (%w/w) of the solvent is about 50% to about 99%.
  • pH of the cleanser is about 4 to about 6.
  • the cleanser is hair cleanser, wherein the pH of the cleanser is about 4 to about 6.
  • a method for cleansing hair using the cleanser as described herein is a method for cleaning hair or skin using the cleanser as described herein.
  • a cleanser comprising: a hair conditioner, wherein hair conditioner is present in the cleanser at about 0.01% (%w/w) to about 10% (%w/w) of the cleaner.
  • the cleanser comprises a skin conditioner.
  • the hair conditioner comprises panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof.
  • the skin conditioner is present in the cleanser at about 0.01% (%w/w) to about 5% (%w/w) of the cleaner.
  • the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylenesulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylenesulfonate, TEA-dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof.
  • the surfactant comprises the amphoteric surfactant.
  • the amphoteric surfactant comprises cocamindopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof.
  • the cleanser comprises an excipient.
  • the excipient is a cosmetically acceptable excipient.
  • the excipient is a dermatologically acceptable excipient.
  • the chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof.
  • the chelating agent is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser.
  • the excipient comprises a buffer.
  • the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L- WSGR Docket No.: 63230-729.601 arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof.
  • the buffer is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser.
  • the excipient comprises a preservative.
  • the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof.
  • the preservative is present in the cleanser at about 0.01% (%w/w) to about 0.1% (%w/w) of the cleanser.
  • the cleanser comprises a solvent.
  • the concentration (%w/w) of the solvent is about 50% to about 99%.
  • the cleanser is hair cleanser. [0031] A method for cleansing hair or using the cleanser as described herein.
  • hair conditioner compositions e.g., rinse off compositions
  • a lipid nanoparticle comprising (e.g., encapsulating) a ceramide and vitamin E, which are useful for protecting hair from ultraviolet damage, mechanical stress damage, and/or environmental damage.
  • conditioner compositions comprising a lipid nanoparticle, wherein the lipid nanoparticle comprises: (1) vitamin E or derivative thereof; and (2) a ceramide.
  • conditioner compositions comprising a lipid nanoparticle (LNP) dispersion, wherein the LNP dispersion comprises: (1) a lipid nanoparticle; (2) vitamin E or derivative thereof; and (3) a ceramide.
  • LNP lipid nanoparticle
  • the Vitamin E or derivative thereof is WSGR Docket No.: 63230-729.601 present at 0.1 to 1% by total weight of the LNP dispersion.
  • the ceramide is present at 0.5 to 5% by total weight of the LNP dispersion.
  • the% by total weight of the LNP dispersion is a measure independent from a% by total weight of the conditioner composition.
  • the LNP dispersion is present at 0.01 to 5% by total weight of the conditioner composition.
  • the LNP dispersion is present at 0.1 to 1% by total weight of the conditioner composition.
  • the LNP dispersion is present at about 0.5% by total weight of the conditioner composition.
  • the vitamin E or derivative thereof comprises: any one of the formulations in Table 13 or Table 14.
  • the lipid nanoparticle is a liposome.
  • the conditioner composition further comprises a cationic polymer.
  • the cationic polymer is associated with lipids of the lipid nanoparticle.
  • the cationic polymer comprises a polymeric quaternary ammonium compound.
  • the polymeric quaternary ammonium compound comprises polyquaternium-4, -7, -11, -16, -22, or -67.
  • the polymeric quaternary ammonium compound is polyquaternium-16.
  • the LNP dispersion comprises any one of the formulations in Table 15 or Table 16. In certain embodiments, the LNP dispersion further comprises an oil, a preservative, or both the oil and the preservative. In certain embodiments, the LNP dispersion comprises any one of the formulations in Table 17, Table 18, or Table 19. In certain embodiments, the LNP dispersion comprises any one of the formulations in Table 20 or Table 21. [0036] In certain embodiments, the conditioner composition further comprises a solvent in addition to water. In certain embodiments, the conditioner composition further comprises a solvent in addition to water.
  • the solvent is selected from: alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate.
  • the solvent other than water is present at 0.1 to 20% by total weight of the conditioner composition. In certain embodiments, the solvent other than water is present at 1 to 10% by total weight of the conditioner composition.
  • the conditioner composition comprises any one of the formulations of Table 22 or Table 23. In certain embodiments, the conditioner composition comprises any one of the formulations of Table 24 or Table 25. [0037] In certain embodiments, the conditioner composition further comprises an emulsifier.
  • the emulsifier is selected from: natural oils, fatty WSGR Docket No.: 63230-729.601 alcohols, silicones (e.g., dimethicone), natural butters, or synthetic esters.
  • the emulsifier is selected from: lecithin, hydrogenated lecithin, phosphatidylcholine, [C12-16 alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl/capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3,
  • the emulsifier is present at 1 to 10% by total weight of the conditioner composition.
  • the conditioner composition comprises any one of the formulations of Table 24 or Table 25. In certain embodiments, the conditioner composition comprises any one of the formulations of Table 26 or Table 27. [0038] In certain embodiments, the conditioner composition further comprises a conditioning agent. In certain embodiments, the conditioner composition comprises any one of the formulations of Table 30, Table 31, Table 32, or Table 33. In certain embodiments, the conditioner composition further comprises a humectant. In certain embodiments, the conditioner composition comprises any one of the formulations of Table 34, Table 35, Table 36, or Table 37. In certain embodiments, the conditioner composition further comprises an emollient.
  • the conditioner composition comprises any one of the formulations of Table 38, Table 39, Table 40, or Table 41. In certain embodiments, the conditioner composition further comprises a pollution protectant. In certain embodiments, the conditioner composition comprises any one of the formulations of Table 42, Table 43, Table 44, or Table 45. In certain WSGR Docket No.: 63230-729.601 embodiments, the conditioner composition further comprises a preservative. In certain embodiments, the conditioner composition comprises any one of the formulations of Table 46, Table 47, Table 48, or Table 49. [0039] In certain embodiments, the conditioner composition further comprises a pH modifier. In certain embodiments, the conditioner composition comprises any one of the formulations of Table 50, Table 51, Table 52, or Table 53.
  • provided herein are methods of protecting hair of an individual, the method comprising: (a) applying the conditioner composition of any one of the preceding embodiments to the hair of the individual. In certain embodiments, the method further comprises: (b) lathering the hair with the conditioner composition; and (c) rinsing the hair of the individual. In some embodiments, provided herein are methods of improving the protective properties of a conditioner composition, the method comprising: (a) adding the LNP dispersion to a conditioner composition to generate the conditioner composition of any one of the preceding embodiments. In certain embodiments, the protective property comprises protection against UV damage.
  • compositions comprising: a lipid nanoparticle dispersion comprising lipid nanoparticles comprising: vitamin E or a derivative thereof; and a ceramide; one or more conditioning agents; and a pollution protectant comprising: an exopolysaccharide; and a glycerol.
  • the vitamin E or a derivative thereof comprises tocopherol acetate, alpha-tocopherol, or a combination thereof.
  • the exopolysaccharide comprises levan, gellan gum, dextran, xanthan gum, hyaluronic acid, Alteromonas Ferment Extract, or a combination thereof.
  • the one or more conditioning agents comprises quaternium-18 bentonite, quaternium-22 hectonite, behentrimonium methosulfate, behentrimonium chloride, benzethonium chloride, benzalkonium chloride, cetrimonium chloride, cetrimonium methosulfate, steartrimonium chloride, stearalkonium chloride, dicetyldimonium chloride, tricetyldimonium chloride, cocotrimonium chloride, dicocodimonium chloride, laurtrimonium chloride, stearamidopropyl dimethylamine, PCA ethyl cocoyl arginate, C 10-40 isoalkylamidopropylethyldimonium ethosulfate, dipalmitoylethyl hydroxyethylmonium methosulfate, shea butter, amidopropyltrimonium chloride, quaternium-15, quatern
  • the one or more conditioning agents comprises behentrimonium methosulfate, behentrimonium chloride, benzethonium chloride, benzalkonium chloride, stearalkonium chloride, cetrimonium chloride, cetrimonium methosulfate, jojoba ester, hydroxypropyl guar hydroxypropyltrimonium chloride, or a combination thereof.
  • the one or more conditioning agents is present at a concentration of about 1% (w/w) to about 10% (w/w) of a total weight of the composition.
  • the composition comprises an emollient comprising a natural oil, a fatty alcohol, a silicone, a natural butter, a synthetic ester, or a combination thereof.
  • the emollient comprises isopropyl palmitate, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid/propanediol copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, capryloyl glycerin/sebacic acid copolymer, C12-15 alkyl benzoate, caprylic/capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate
  • the emollient is present at about 1% (w/w) to about 20% (w/w) of a total weight of the composition.
  • the lipid nanoparticle has an average particle size of about 100 nm to about 900 nm.
  • the lipid nanoparticle further comprises a phospholipid, a sterol, a sphingolipid, a glycolipid, or a combination thereof.
  • the lipid nanoparticle further comprises a cationic polymer comprising WSGR Docket No.: 63230-729.601 polyquaternium-4, polyquaternium-7, polyquaternium-11, polyquaternium-16, polyquaternium-22, or polyquaternium-67.
  • the lipid nanoparticle further comprises a mixture of lipids obtained from soybean, egg, milk, rapeseed, cottonseed, or sunflower, or a combination thereof.
  • the glycerol comprises ethylene glycol, propylene glycol, or butylene glycol, or a combination thereof.
  • pollution protectant and the lipid nanoparticle dispersion are present in a 1:1 ratio by weight of a total weight of the composition.
  • the shielding comprises transmitting about 0% to about 99% of UV light into a hair cortex of the hair as determined by a denature temperature mean value, fiber breakage, or a combination thereof.
  • DETAILED DESCRIPTION [0043]
  • the cleanser comprises a hair conditioner; a hair conditioner and a cleansing agent; a hair conditioner and a skin conditioner; a skin conditioner and a cleansing agent; or a hair conditioner, a skin conditioner, and a cleansing agent.
  • the cleanser comprises a hair conditioner and at least one of: a skin conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient.
  • the cleanser comprises a skin conditioner, and at least one of: a hair conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient.
  • the cleanser comprises a cleansing agent, and at least one of: a hair conditioner; a skin conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient.
  • the cleanser comprises a cosmetically or dermatologically acceptable excipient, and at least one of: a hair conditioner, a skin conditioner, or a cleansing agent.
  • the cleanser comprises a hair conditioner, a skin conditioner, a cleansing agent, a cosmetically or dermatologically acceptable excipient, or a combination of two or more thereof.
  • the cleanser comprises a hair conditioner, a skin conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient.
  • the cleansers described herein provide a long-lasting improved texture and improved manageability to the hair when dried. After prolonged WSGR Docket No.: 63230-729.601 use, the cleansers described herein may provide the hair with soft, shiny, undamaged texture and with the other desired features. The cleansers described herein may not strip the hair of any essential oils, mitigates protein loss, and repairs the underlying hair damage, thus avoiding excess reliance on conditioners that coat the hair fiber to achieve desired properties.
  • the cleansers described herein do not contribute to the build-up of excess conditioning agents or other products that can ultimately weigh hair down.
  • the cleanser provided herein comprise a solvent, a hair conditioner, a skin conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient.
  • the cleanser described herein cleans the hair while maintaining an optimum pH environment of hair to minimize fiber swelling and preserve structural integrity.
  • the cleansers may clean the scalp while maintaining an optimum pH environment to avoid over drying the scalp and without disrupting the natural barrier function of the scalp.
  • the cleansers described herein may have a pH optimized to cleanse the hair and scalp.
  • the pH of the cleanser is optimized to promote the efficacy of certain ingredients in the cleanser. In some embodiments, the pH of the cleanser is optimized to promote the efficacy of salicylic acid. In some embodiments, the pH of the cleanser is optimized to promote chelation of certain minerals and metals. In some embodiments, the pH of the cleanser is optimized to minimize swelling of the cuticle. In some embodiments, reduced swelling of the cuticle reduces tangling of the hair. In some embodiments, the pH of the cleanser is optimized to protect the structural integrity of the hair and mitigate protein and lipid loss. [0047] In some embodiments, the cleanser has a pH about 1 to about 7.
  • the cleanser has a pH of about 1, about 1.25 about 1.5, about 1.75, about 2, about 2.25, about 2.5, about 2.75, about 3, about 3.25, about 3.5, about 3.75, about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, about 7, and any values therebetween.
  • the cleanser has a pH about 1 to about 7, about 2 to about 7, about 3 to about 7, about 3.5 to about 7, about 4 to about 7, about 4 to about 6.
  • the cleanser described herein provides a long-lasting improved texture and improved manageability to the hair when dried.
  • the cleansers described herein provide the hair with soft, shiny, undamaged texture and with the other desired features.
  • WSGR Docket No.: 63230-729.601 The cleansers described herein do not strip the hair of any essential oils, mitigates protein loss, and repairs the underlying hair damage, thus avoiding excess reliance on conditioners that coat the hair fiber to achieve desired properties.
  • the cleanser provided herein may also absorb undesirable components of hair and scalp, such as excess sebum or oils, through the use of detoxifying agents. Further, due to their limited ingredients, the cleansers described herein do not contribute to the build-up of excess conditioning agents or other products that can ultimately weigh hair down.
  • the cleanser comprises a detoxifying agent.
  • the detoxifying agent comprises an absorbent such as charcoal. Charcoal can sequester metal ions at low levels without further complicating formulation with viscosity-altering chelating agents. Charcoal contains many small pores that create a large surface area capable of adsorbing heavy metals including iron (Fe), chromium (Cr), cadmium (Cd), and copper (Cu). Such adsorption of heavy metals can lead to detoxifying effect on the hair or scalp.
  • the cleanser provided herein comprises a detoxifying agent. In some embodiments, the cleanser provided herein comprises a detoxifying agent, and at least one of a hair conditioner, a skin conditioner, a cleansing agent, or an excipient.
  • the cleanser provided herein comprises a detoxifying agent and a hair conditioner.
  • the cleanser provided herein comprises a detoxifying agent, a hair conditioner, and at least one of a skin conditioner, a cleansing agent, or an excipient.
  • the cleanser provided herein comprises a detoxifying agent, a hair conditioner, a skin conditioner, a cleansing agent, and an excipient.
  • the cleanser provided herein comprises a solvent, a detoxifying agent, a hair conditioner, a skin conditioner, a cleansing agent, an excipient, or a combination of two or more thereof.
  • the cleanser comprises a hair conditioner and at least one of: a skin conditioner; a cleansing agent; or a excipient.
  • the cleanser comprises a skin conditioner, and at least one of: a hair conditioner; a cleansing agent; or a excipient.
  • the cleanser comprises a cleansing agent, and at least one of: a hair conditioner; a skin conditioner; a cleansing agent; or a excipient.
  • the cleanser comprises a excipient, and at least one of: a hair conditioner, a skin conditioner, or a cleansing agent.
  • the cleanser comprises a hair conditioner, a skin conditioner, a cleansing agent, a excipient, WSGR Docket No.: 63230-729.601 or a combination of two or more thereof.
  • the cleanser comprises a hair conditioner, a skin conditioner, a cleansing agent, and a excipient.
  • the cleanser described herein cleans the hair while maintaining an optimum pH environment of hair to minimize fiber swelling and preserve structural integrity. Additionally, the hair cleansers clean the scalp while maintaining an optimum pH environment to avoid over drying the scalp and without disrupting the natural barrier function of the scalp.
  • the cleansers described herein have a pH optimized to cleanse the hair and scalp.
  • the pH of the cleanser is optimized to promote the efficacy of certain ingredients in the compositions. In some embodiments, the pH of the cleanser is optimized to promote the efficacy of salicylic acid. In some embodiments, the pH of the composition is optimized to promote chelation of certain minerals and metals. In some embodiments, the pH of the composition is optimized to minimize swelling of the cuticle. In some embodiments, reduced swelling of the cuticle reduces tangling of the hair. In some embodiments, the pH of the composition is optimized to protect the structural integrity of the hair and mitigate protein and lipid loss. [0053] In some embodiments, the cleanser has a pH about 1 to about 7.
  • the cleanser has a pH of about 1, about 1.25 about 1.5, about 1.75, about 2, about 2.25, about 2.5, about 2.75, about 3, about 3.25, about 3.5, about 3.75, about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, about 7, about, and any values therebetween.
  • the cleanser has a pH about 1 to about 7, about 2 to about 7, about 3 to about 7, about 3 to about 6, about 2 to about 6, and any values therebetween.
  • Hair conditioners [0054]
  • the cleanser described herein includes a hair conditioner.
  • the hair conditioner may repair and/or improve the properties of hair, such as elasticity, resistance, texture (i.e., softness, smoothness, etc.), and/or appearance.
  • the hair conditioner detangles hair fiber.
  • the hair conditioner softens hair fiber.
  • the total concentration (%w/w) of the hair conditioner in the cleanser is about 0.01% to about 10.0%. In some embodiments, the concentration (%w/w) of the hair conditioner in a cleanser comprising one hair conditioner is about 0.01% to about 10.0%. In some embodiments, the concentration of each hair conditioner in a cleanser comprising two or more hair conditions is about 0.01% to about 10%.
  • the concentration of the hair conditioner in the cleanser is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.7%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, and any values therebetween.
  • the concentration of the hair conditioner in the cleanser is about 0.01% to about 10%, about 0.05% to about 9.5%, about 0.20% to about 9%, about 0.30% to about 8.5%, about 0.40% to about 8%, about 0.50% to about 7.5%, about 0.60% to about 7%, about 0.70% to about 6.5%, about 0.80% to about 6%, about 0.90% to about 5.5%, and about 1% to about 5%.
  • the total concentration (%w/w) of the hair conditioner in the cleanser is about 0.01% (w/w) to about 10.0% (w/w) of a total weight of the cleanser.
  • the total concentration of the hair conditioner in the WSGR Docket No.: 63230-729.601 cleanser is about 0.01% (w/w), about 0.05% (w/w), about 0.10% (w/w), about 0.15% (w/w), about 0.20% (w/w), about 0.25% (w/w), about 0.30% (w/w), about 0.35% (w/w), about 0.40% (w/w), about 0.45% (w/w), about 0.50% (w/w), about 0.55% (w/w), about 0.60% (w/w), about 0.65% (w/w), about 0.70% (w/w), about 0.75% (w/w), about 0.80% (w/w), about 0.85% (w/w), about 0.90% (w/w), about 0.95% (w/w), about 1.0% (w/w), about 1.5% (w/w), about 2% (w/w), about 2.5% (w/w), about 3% (w/w), about 3.5% (w/w), about
  • the total concentration of the hair conditioner in the cleanser is about 0.01% (w/w) to about 10% (w/w), about 0.05% (w/w) to about 9.5% (w/w), about 0.20% (w/w) to about 9% (w/w), about 0.30% (w/w) to about 8.5% (w/w), about 0.40% (w/w) to about 8% (w/w), about 0.50% (w/w) to about 7.5% (w/w), about 0.60% (w/w) to about 7% (w/w), about 0.70% (w/w) to about 6.5% (w/w), about 0.80% (w/w) to about 6% (w/w), about 0.90% (w/w) to about 5.5% (w/w), or about 1% (w/w) to about 5% (w/w) of the total weight of the cleanser.
  • the cleanser described herein includes a skin conditioner.
  • the skin conditioner supports the skin’s barrier function and/or help retain moisture.
  • the skin conditioner moisturizes skin.
  • the skin conditioner hydrates the skin.
  • Non- limiting example of a skin conditioner can include niacinamide, allantoin, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, sodium hyaluronate crosspolymer, jojoba esters, hydrolyzed jojoba esters, oleic acid, linoleic acid, linolenic acid, lactobionic acid, ursolic acid/sodium ursolate, nordihydroguaiaretic acid, ceramides, fructooligosaccharides, galactoarabinan, schizophyllan, Anetholea anisate leaf extract, Tetraselmis suecica extract, saccharide isomerase, Alteromonas ferment extract, Pseudoalteromonas ferment extract, Corylus avellana leaf extract, Phyllanthus emblica fruit extract, Betula alba juice, Saccharum off
  • the total concentration (%w/w) of the skin conditioner in the cleanser is about 0.01% to about 10.0%.
  • concentration WSGR Docket No.: 63230-729.601 (%w/w) of the skin conditioner in a cleanser comprising one skin conditioner is about 0.01% to about 10.0%.
  • concentration of each skin conditioner in a cleanser comprising two or more skin conditions is about 0.01% to about 10%.
  • the concentration of the skin conditioner in the cleanser is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.7%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, and any values therebetween.
  • the concentration of the skin conditioner in the cleanser is about 0.01% to about 10%, about 0.05% to about 9.5%, about 0.20% to about 9%, about 0.30% to about 8.5%, about 0.40% to about 8%, about 0.50% to about 7.5%, about 0.60% to about 7%, about 0.70% to about 6.5%, about 0.80% to about 6%, about 0.90% to about 5.5%, and about 1% to about 5%.
  • the total concentration (%w/w) of the skin conditioner in the cleanser is about 0.01% (w/w) to about 10.0% (w/w) of a total weight of the cleanser.
  • the total concentration of the skin conditioner in the cleanser is about 0.01% (w/w), about 0.05% (w/w), about 0.10% (w/w), about 0.15% (w/w), about 0.20% (w/w), about 0.25% (w/w), about 0.30% (w/w), about 0.35% (w/w), about 0.40% (w/w), about 0.45% (w/w), about 0.50% (w/w), about 0.55% (w/w), about 0.60% (w/w), about 0.65% (w/w), about 0.70% (w/w), about 0.75% (w/w), about 0.80% (w/w), about 0.85% (w/w), about 0.90% (w/w), about 0.95% (w/w), about 1.0% (w/w), about 1.5% (w/w), about 2% (w/w), about 2.5% (w/w), about 3% (w/w), about 3.5% (w/w), about 4% (w/w), about 4.5% (w/w), about
  • the total concentration of the skin conditioner in the cleanser is about 0.01% (w/w) to about 10% (w/w), about 0.05% (w/w) to about 9.5% (w/w), about 0.20% (w/w) to about 9% (w/w), about 0.30% (w/w) to about 8.5% (w/w), about 0.40% (w/w) to about 8% (w/w), about 0.50% (w/w) to about 7.5% (w/w), about 0.60% (w/w) to about 7% (w/w), about 0.70% (w/w) to about 6.5% (w/w), about 0.80% (w/w) to about 6% (w/w), about 0.90% (w/w) to about 5.5% (w/w), or about 1% (w/w) to about 5% (w/w) of the total weight of the cleanser.
  • the cleanser described herein comprises a detoxifying agent.
  • the detoxifying agent can remove dirt, oil, sebum, or any product build-up from the hair or scalp.
  • the detoxifying agent may clean the scalp of dandruff, acne, or scabbing.
  • the detoxifying agent stimulates hair follicles to allow for hair growth.
  • the detoxifying agent reduces itchiness, oiliness, or inflammation.
  • the detoxifying agent comprises an absorbent.
  • the absorbent comprises charcoal such as a charcoal powder.
  • the one or more detoxifying agent comprises a zeolite.
  • the zeolite comprises kaolin clay, bentonite clay, French green clay, Brazilian clay, or a combination of two or more thereof.
  • the one or more detoxifying agents comprises a porous material comprising pores.
  • the pores enable absorption of dirt, oil, or buildup, or a combination or two or more thereof.
  • build up includes hair product build up.
  • the pores comprise an average diameter of about 0.1 m to about 100 m, about 0.2 m to about 200 m, about 0.3 m to about 300 m, about 0.4 m to about 400 m, about 0.5 m to about 500 m, about 0.6 m to about 600 m, about 0.7 m to about 700 m, about 0.8 m to about 800 m, about 0.9 m to about 900 m, about 1 m to about 1000 m, about 1 m to about 100 m, about 2 m to about 200 m, about 2 m to about 300 m, about 3 m to about 400 m, about 3 m to about 500 m, about 4 m to about 600 m, about 4 m to about 700 m, about 5 m to about 800 m, about 5 m to about 900 m, about 6 m to about 1000 m, about 0.1 m to about 10 m, about 0.1 m to about 20 m, about 0.1 m to about 50 m, about 0.1
  • the detoxifying agent comprises an average diameter of about 1 m to about 100 m, about 2 m to about 200 m, about 3 m to about 300 m, about 4 m to about 400 m, about 5 m to about 500 m, about 6 m to about 600 m, about 7 m to about 700 m, about 8 m to about 800 m, about 9 m to about 900 m, about 10 m to about 1000 m, about 10 m to about 100 m, about 20 m to about 200 m, about 30 m to about 300 m, about 40 m to about 400 m, about 50 m to about 500 m, about 60 m to about 600 m, about 70 m to about 700 m, about 80 m to about 800 m, about 90 m to about 900 m, about 100 m to about 1000 m, about 1 m to about 10 m, about 1 m to about 20 m, about 1 m to about 50 m, about 1 m to
  • the detoxifying agent is substantially monodispersed. In some embodiments, the detoxifying agent is substantially polydisperse. [0064] In some embodiments, the concentration (%w/w) of the detoxifying agent in the cleanser is about 0.01% to about 5.0%.
  • the concentration of the detoxifying agent in the cleanser is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.70%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, about 2.0%, about 2.0%, about 2.1%, about 2.2%, about 2.3%, about 2.4%, about 2.5%, about 2.6%, about 2.7%, about 2.8%, about 2.9%, about 3.0%, about 3.1%, about 3.2%, about 3.3%, WSGR Docket No.: 63230-729.601 about 3.4%, about 3.5%, about 3.6%, about 3.7%, about 3.8%, about 3.9%, about 4.0%, about 4.1%, about 4.2%, about 4.3%, about 4.4%, about 4.5%, about 4.6%, about 4.7%, about 4.8%, about
  • the concentration of the detoxifying agent in the cleanser is about 0.01% to about 0.95%, about 0.05% to about 1.0%, about 0.20% to about 0.90%, about 0.30% to about 0.85%, about 0.40% to about 0.80%, about 0.50% to about 0.75%, about 0.60% to about 0.70%, and about 0.70% to about 5.0%.
  • Cleansing agents [0065]
  • the cleanser described herein includes a cleansing agent.
  • the cleansing agent helps to clean the hair.
  • the cleansing agent does not remove or replace any essential oils.
  • Non- limiting example of a cleansing agent includes: an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or any combinations thereof.
  • the surfactants may provide good foaming profiles and a stable rheology in addition to being efficient cleansers.
  • Anionic surfactants tend to be top performers in these categories; however, consumer perception of the most efficient traditionally employed classes (i.e., sulfates) has made reception of these challenging.
  • surfactants tend to be neutral or alkaline, but an acidic composition demands performance and stability at low pH and in potentially hard water.
  • Sulfonates in particular alkyl sulfonates or olefin sulfonates, exemplify one class that meets the specified criteria.
  • These surfactants exhibit particularly good synergy with alpha hydroxyl acids or salicylic acids.
  • single-surfactant systems often lack one aspect or another, so it is beneficial to utilize a blend.
  • Amphoteric surfactants impart gentleness and improve sensory profiles.
  • hydroxysultaines possess a remarkably low irritation profile and improve the mildness of surfactant compositions while boosting foam and stability, permitting lower total surfactant levels—another critical criterium in compositions meant to respect the skin barrier of the scalp. They also exhibit notably broad pH and electrolyte tolerance, making them excellent cleansers in hard water and in combination with acidic ingredients.
  • Amino acid-derived surfactants can cleanse while simultaneously moisturizing skin or conditioning hair. These surfactants may be used daily on the hair or skin when formulated appropriately.
  • biosurfactants represent WSGR Docket No.: 63230-729.601 yet another type of high-performing cleanser molecule that holds the added benefit of superior environmental compatibility, be that more sustainable source materials, improved biodegradability, or greener manufacturing.
  • the cleansing agent comprises an anionic surfactant.
  • the cleansing agent is an anionic surfactant.
  • Non-limiting example of an anionic surfactant includes sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylenesulfonate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myreth sulfate, sodium xylenesulfonate, sodium C14-16 olefin sulfonate, sodium C14-16 alpha olefin sulfonate, disodium lauryl sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoy
  • the cleansing agent comprises an amphoteric surfactant.
  • the cleansing agent is an amphoteric surfactant.
  • an amphoteric surfactant includes cocamindopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium dilauramidoglutamide lysine, sodium cocoamphopropionate, lauroamphoacetate, and any combinations thereof.
  • the cleansing agent comprises a non-ionic surfactant.
  • the cleansing agent is a non-ionic surfactant.
  • Non-limiting example of a non-ionic surfactant includes decyl glucoside, lauryl glucoside, coco-glucoside, cocoyl methyl glucamide, capryloyl/caproyl methyl glucamide, lauroyl/myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, and combinations thereof.
  • WSGR Docket No.: 63230-729.601 [0071]
  • the cleansing agent comprises a biosurfactant.
  • the cleansing agent is a biosurfactant.
  • a biosurfactant includes Sapindus mukorossi (soapnut) extract, saponin, lipopeptide, canola sophorolipid, potassium cocoyl hydrolyzed oat protein, starmella bombicola/Brassica oil ferment, glycoside, glycolipid, rhamnolipid, phospholipid, sophorolipid, and any combinations thereof.
  • the total concentration (%w/w) of the cleansing agent in the cleanser is about 0.1% to about 20.0%.
  • the concentration (%w/w) of the cleansing agent in a cleanser comprising one skin condition is about 0.1% to about 20.0%.
  • the concentration of each cleansing agent in a cleanser comprising two or more cleansing agent is about 0.1% to about 20%. In some embodiments, the concentration (%w/w) of the cleansing agent in the cleanser is about 0.1% to about 20%. In some embodiments, the concentration of the cleansing agent in the cleanser is about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, 0.7%, about 0.8%, about 0.9%, about 1.0%, about 1.2%, about 1.4% , about 1.6%, about 1.8%, about 2.0%, about 2.5%, about 3.0%, about 3.5%, about 4.0%, about 4.5%, about 5.0%, about 5.5%, about 6.0%, about 6.5%, about 7.0%, about 7.5%, about 8.0%, about 8.5%, about 9.0%, about 9.5%, about 10.0%, about 10.5%, about 11.0%, about 11.5%, about 12.0%, about 12.5%, about 13%, about 13.5%, about 14%, about 14.5%, about 15%, about 16%, about 17%, about 18%, about 19%,
  • the concentration of the cleansing agent in the cleanser is about 0.1% to about 20%, about 0.2% to about 19%, about 0.3% to about 18%, about 0.4% to about 17%, about 0.5% to about 16%, about 0.6% to about 15%, about 0.7% to about 14.5%, about 0.8% to about 14%, about 0.9% to about 13.5%, about 1.0% to about 13%, about 1.5% to about 12.5%, about 2.0% to about 12%, about 2.5% to about 11.5%, about 3.0% to about 11%, about 3.5% to about 10.5%, and about 4% to about 10%.
  • the total concentration (%w/w) of the cleansing agent in the cleanser is about 0.01% (w/w) to about 20.0% (w/w) of a total weight of the cleanser.
  • the concentration (%w/w) of the cleansing agent is the concentration of one or more surfactants in the cleanser at about 0.1% to about 30%.
  • the concentration (%w/w) of the cleansing agent is the concentration of a cleansing agent in the cleanser at about 0.1% to about 30%.
  • the concentration (%w/w) of the cleansing agent is the concentration of a cleansing agent WSGR Docket No.: 63230-729.601 in the cleanser at about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 5%, about 0.1% to about 10%, about 0.1% to about 15%, about 0.1% to about 18%, about 0.1% to about 20%, about 0.1% to about 23%, about 0.1% to about 25%, about 0.1% to about 28%, about 0.1% to about 30%, about 0.5% to about 1%, about 0.5% to about 5%, about 0.5% to about 10%, about 0.5% to about 15%, about 0.5% to about 18%, about 0.5% to about 20%, about 0.5% to about 23%, about 0.5% to about 25%, about 0.5% to about 28%, about 0.5% to about 30%, about 1% to about 5%, about 1% to about 10%, about 1% to about 15%, about 1% to about 18%, about 1% to about 20%, about 0.5% to about 23%, about 0.5% to about 25%, about 0.
  • the concentration (%w/w) of the cleansing agent is the concentration of a cleansing agent in the cleanser at about 0.1%, about 0.5%, about 1%, about 5%, about 10%, about 15%, about 18%, about 20%, about 23%, about 25%, about 28%, or about 30%. In some embodiments, the concentration (%w/w) of the cleansing agent is the concentration of a cleansing agent in the cleanser at between at least about 0.1%, about 0.5%, about 1%, about 5%, about 10%, about 15%, about 18%, about 20%, about 23%, about 25%, or about 28%.
  • the concentration (%w/w) of the cleansing agent is the concentration of a cleansing agent in the cleanser at between at most about 0.5%, about 1%, about 5%, about 10%, about 15%, about 18%, about 20%, about 23%, about 25%, about 28%, or about 30%. [0074] In some embodiments, the concentration (%w/w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at about 0.1% to about 25%. In some embodiments, the concentration (%w/w) of the cleansing agent is the concentration of one surfactant or each one of the one or more WSGR Docket No.: 63230-729.601 surfactants in the cleanser at about 0.1% to about 25%.
  • the concentration (%w/w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at about 0.1% to about 0.2%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 2%, about 0.1% to about 10%, about 0.1% to about 12%, about 0.1% to about 13%, about 0.1% to about 14%, about 0.1% to about 15%, about 0.1% to about 18%, about 0.1% to about 25%, about 0.2% to about 0.5%, about 0.2% to about 1%, about 0.2% to about 2%, about 0.2% to about 10%, about 0.2% to about 12%, about 0.2% to about 13%, about 0.2% to about 14%, about 0.2% to about 15%, about 0.2% to about 18%, about 0.2% to about 25%, about 0.5% to about 1%, about 0.5% to about 2%, about 0.5% to about 2%, about 0.5% to about 10%, about 0.5% to about 12%, about 0.5% to about 13%, about 0.5% to about 14%, about
  • the concentration (%w/w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at about 0.1%, about 0.2%, about 0.5%, about 1%, about 2%, about 10%, about 12%, about 13%, about 14%, about 15%, about 18%, or about 25%. In some embodiments, the concentration (%w/w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at between at least about 0.1%, about 0.2%, about 0.5%, about 1%, about 2%, about 10%, about 12%, about 13%, about 14%, about 15%, or about 18%.
  • the concentration (%w/w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at between at most about 0.2%, about 0.5%, about 1%, about 2%, about 10%, about 12%, about 13%, about 14%, about 15%, about 18%, or about 25%.
  • WSGR Docket No.: 63230-729.601 Excipients [0075]
  • the cleanser described herein comprises a cosmetically or dermatologically acceptable excipient.
  • Non-limiting example of the cosmetically or dermatologically acceptable excipient includes emulsifiers, preservatives, antioxidants, thickeners, chelating agents, sunscreen agents, vitamins, dyes, hair coloring agents, proteins, amino acids, organic polymers, natural extracts such as plant extracts, humectants, fragrances, perfumes, oils, emollients, lubricants, butters, penetrants, thickeners, viscosity modifiers, polymers, resins, hair fixatives, silicones, film formers, surfactants, detergents, emulsifiers, opacifying agents, volatiles, propellants, liquid vehicles, carriers, salts, buffering agents, neutralizing agents, anti-static agents, anti-frizz agents, anti-dandruff agents, aliphatic alcohols, absorbents, or naturally derived polymers, or any combinations thereof.
  • the concentration of the cosmetically or dermatologically acceptable excipient in the cleanser is about 0.1%, about 0.5%, about 1.0%, about 2.0%, about 3.0%, about 4.0%, about 5.0%, about 6.0%, about 7.0%, about 8.0%, about 9.0%, about 10.0%, about 11.0%, about 12.0%, about 13.0%, about 14.0%, about 15.0%, about 16.0%, about 17.0%, about 18.0%, about 19.0%, about 20.0%, about 21.0%, about 22.0%, about 23.0%, about 24.0%, about 25.0%, about 26.0%, about 27.0%, about 28.0%, about 29.0%, about 30.0%, and any values therebetween.
  • the concentration (%w/w) of the cosmetically or dermatologically acceptable excipient in the cleanser is about 0.1% to about 29.0%, about 0.5% to about 28.0%, about 1.0% to about 27.0%, about 2.0% to about 26.0%, about 3.0% to about 25.0%, about 4.0% to about 24.0%, about 5.0% to about 23.0%, about 6.0% to about 22.0%, about 7.0% to about 21.0%, about 8.0% to about 20.0%, about 9.0% to about 19.0%, about 10.0% to about 18.0%, about 11.0% to about 17.0%, about 12.0% to about 16.0%, about 13.0% to about 15.0%, about 14.0% to about 14.5%, and about 14.5% to about 30.0%.
  • the cosmetically or dermatologically acceptable excipient comprises an emulsifier. In some embodiments, the cosmetically or dermatologically acceptable excipient is an emulsifier.
  • Non-limiting example of an emulsifier includes caprylic/capric/diglyceryl succinate, C 14-16 glycol palmitate, C 18-20 glycol isostearate, cocamidopropyl lauryl ether, dipentaerythrityl hydroxystearate, dipentaerythrityl hydroxyisostearate, dipentaerythrityl hexacaprate/caprylate, palm kernel glycerides, lecithin, hydrogenated lecithin, phosphatidylcholine, C12-16 alcohols, palmitic acid, glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, glyceryl stearate citrate, sodium stearoyl lactylate, sodium stearoyl glutamate,
  • the cosmetically or dermatologically acceptable excipient comprises a chelating agent.
  • the cosmetically or dermatologically acceptable excipient is a chelating agent.
  • a chelating agent includes phytic acid, sodium phytate, caprylhydroxamic acid, trisodium dicarboxymethyl alaninate, gluconic acid, sodium gluconate, pentasodium pentetate, sodium carboxymethyl inulin, tetrasodium glutamate diacetate, trisodium ethylenediamine succinate, sodium thiosulfate, diiospropyl oxalate, disodium EDTA, disodium EDTA-copper, HEDTA, oxalic acid, potassium citrate, sodium citrate, sodium oxalate, TEA-EDTA, tetrasodium EDTA, trisodium EDTA, trisodium HEDTA, or any combinations thereof
  • the cosmetically or dermatologically acceptable excipient comprises a preservative.
  • the cosmetically or dermatologically acceptable excipient is a preservative.
  • a WSGR Docket No.: 63230-729.601 preservative includes benzoic acid, butyl paraben, diazolidinyl urea, DMDM hydantoin, ethyl paraben, imidazolidinyl urea, iodopropynyl butylcarbamate, isobutyl paraben, methyl paraben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propyl paraben, sodium benzoate, potassium sorbate, ethylhexylglycerin, gluconolactone, or any combinations thereof.
  • the cosmetically or dermatologically acceptable excipient comprises a thickener.
  • the cosmetically or dermatologically acceptable excipient is a thickener.
  • a thickener includes lauryl lactate, hydroxypropyl starch phosphate, acrylates copolymer, ammonium acryloyldimethyltaurate, sodium acryloyldimethyltaurate/VP copolymer, sodium acrylate/sodium acryloyldimethyl taurate copolymer, sodium polyacrylate, polyacrylate crosspolymer-11, carbomer, acrylates/C10-30 alkyl acrylate crosspolymer, hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer, lithium magnesium sodium silicate, sodium magnesium fluorosilicate, glycol distearate, hydrogenated castor oil, hydrogenated castor oil hydroxystearate, hydrogenated castor oil isostearate, hydrogen
  • the cosmetically or dermatologically acceptable excipient comprises an anti-static agent.
  • the cosmetically or dermatologically acceptable excipient is an anti-static agent.
  • the anti-static agent is a cationic surfactant.
  • Non-limiting example of an anti-static agent includes quaternary ammonium compounds, behentrimonium chloride, behentrimonium methosulfate, cetrimonium chloride, cetrimonium methosulfate, benzalkonium chloride, benzethonium chloride, cinnamidopropyltrimonium chloride, cocotrimonium chloride, dicetyldimonium chloride, dicocodimonium chloride, laurtrimonium chloride, stearamidopropyl dimethylamine, steartrimonium chloride, stearalkonium chloride, tricetyldimonium chloride, PCA ethyl cocoyl arginate, C 10-40 isoalkylamidopropylethyldimonium ethosulfate, dipalmitoylethyl hydroxyethylmonium methosulfate, shea butter, amidopropyltrimonium chloride, or any combinations thereof.
  • the cosmetically or dermatologically acceptable excipient comprises a naturally derived polymer.
  • the cosmetically or dermatologically acceptable excipient is a naturally derived polymer.
  • a naturally derived polymer includes xanthan gum, pullulan, algin, tetragonoloba (guar) gum, sclerotium gum, acacia Senegal gum, cellulose, cellulose gum, WSGR Docket No.: 63230-729.601 carboxymethylcellulose, carbomer, hydroxypropyl starch phosphate, guar hydroxypropyltrimonium chloride, carboxymethyl hydroxyethyl cellulose, carboxymethyl hydroxypropyl guar, cellulose, ethyl cellulose, hydroxybutyl methylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, lauryl polyglucose, and any combinations thereof.
  • the cosmetically or dermatologically acceptable excipient comprises an amino acid such as L-Cysteine. In some embodiments, the cosmetically or dermatologically acceptable excipient is an amino acid such as L- Cysteine. [0084] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a humectant. In some embodiments, the cosmetically or dermatologically acceptable excipient is a humectant.
  • Non-limiting example of a humectant includes 1,2,6 hexanetriol, dipropylene glycol, glycerin, butylene glycol, caprylyl glycol, pentylene glycol, isopentyldiol, hexylene glycol, panthenol, phytantriol, propylene glycol, propanediol, sodium PCA, sorbitol, triethylene glycol, polyglyceryl sorbitol, glucose, fructose, mannitol, xylitol, inositol, trehalose, polydextrose, potassium PCA, hydrogenated honey, hyaluronic acid, inositol, erythritol, capryl glycol, acetamidoethoxyethanol, or any combinations thereof.
  • the cosmetically or dermatologically acceptable excipient comprises a cationic polymer.
  • the cosmetically or dermatologically acceptable excipient is a cationic polymer.
  • Non-limiting example of a cationic polymer includes polyquaternium-10, polyquaternium-7, polyquaternium-11, polyquaternium-57, quaternium-15, quaternium-18, quaternium-22, quaternium-87, guar hydroxypropyltrimonium chloride, or any combinations thereof.
  • the cosmetically or dermatologically acceptable excipient comprises a non-ionic surfactant.
  • the cosmetically or dermatologically acceptable excipient is a non-ionic surfactant.
  • Non-limiting example of a non-ionic surfactant includes decyl glucoside, lauryl glucoside, coco-glucoside, cocoyl methyl glucamide, capryloyl/caproyl methyl glucamide, lauroyl/myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, and combinations thereof.
  • the non-ionic surfactant is a solubilizer, emulsifier, stabilizer, emollient, thickener, or any combinations thereof.
  • the cosmetically or dermatologically acceptable excipient comprises a silicone.
  • the cosmetically or WSGR Docket No.: 63230-729.601 dermatologically acceptable excipient is a silicone.
  • a silicone includes amodimethicone, dimethicone cyclomethicone, cyclopentasiloxane, dimethicone, dimethicone copolyol, dimethiconol, hydrolyzed wheat protein hydroxypropyl polysiloxane, trimethylsilylamodimethicone, or any combinations thereof.
  • the cosmetically or dermatologically acceptable excipient comprises a protein.
  • the cosmetically or dermatologically acceptable excipient is a protein.
  • Non-limiting example of a protein includes cocodimonium hydroxypropyl hydrolyzed casein, cocodimonium hydroxypropyl hydrolyzed collagen, cocodimonium hydroxypropyl hydrolyzed hair keratin, cocodimonium hydroxypropyl hydrolyzed keratin, cocodimonium hydroxypropyl hydrolyzed rice protein, cocodimonium hydroxypropyl hydrolyzed silk, cocodimonium hydroxypropyl hydrolyzed soy protein, cocodimonium hydroxypropyl hydrolyzed wheat protein, cocodimonium hydroxypropyl silk amino acids, cocoyl hydrolyzed collagen, cocoyl hydrolyzed keratin, hydrolyzed keratin, hydrolyzed oat flour, hydrolyzed silk, hydrolyzed silk protein, hydrolyzed soy protein, hydrolyzed wheat protein, hydrolyzed quinoa, hydrolyzed elastin, hydrolyzed collagen,
  • the cosmetically or dermatologically acceptable excipient comprises a vitamin.
  • the cosmetically or dermatologically acceptable excipient is a vitamin.
  • Non-limiting example of a vitamin includes retinol, retinyl palmitate, ascorbic acid, tocopherol, tocopherol acetate, or any combinations thereof.
  • the cosmetically or dermatologically acceptable excipient comprises a natural extract. In some embodiments, the cosmetically or dermatologically acceptable excipient is a natural extract.
  • Non-limiting example of a natural extract includes Aloe barbadensis leaf extract, Yucca schidigera leaf extract, Yucca schidigera root extract, Camellia sinensis leaf extract, Equisetum arvense leaf extract, Hamamelis virginiana leaf extract, Macrocystis pyrifera kelp extract, or combinations thereof.
  • the cosmetically or dermatologically acceptable excipient comprises an emollient. In some embodiments, the cosmetically or dermatologically acceptable excipient is an emollient.
  • Non-limiting example of an emollient includes isopropyl lauroyl sarcosinate, phenethyl benzoate, C12-15 alkyl benzoate, caprylic/capric triglyceride, cetyl octanoate, octyldodecanol, dilinoleic WSGR Docket No.: 63230-729.601 acid/propanediol copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, capryloyl glycerin/sebacic acid copolymer, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol
  • the cosmetically or dermatologically acceptable excipient comprises an antioxidant.
  • the cosmetically or dermatologically acceptable excipient is an antioxidant.
  • an antioxidant includes carnosine, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, daucus carota sativa root cell culture lysate, monoammonium glycyrrhizinate, alpha lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus WSGR Docket No.: 63230-729.601 officinalis (rosemary) leaf extract (WS), Vitis vinifera (grape) seed extract, Camellia sinensis leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europea (olive) leaf extract, oleuropin, Punica granatum bark/fruit extract, punicalagin, ella
  • the cosmetically or dermatologically acceptable excipient comprises a buffering agent.
  • the cosmetically or dermatologically acceptable excipient is a buffering agent.
  • a buffering agent includes ascorbic acid, citric acid, lactic acid, glycolic acid, tartaric acid, malic acid, L-arginine, potassium hydroxide, sodium hydroxide, triethanolamine, sodium bicarbonate, or any combinations thereof.
  • the cosmetically or dermatologically acceptable excipient comprises a salt. In some embodiments, the cosmetically or dermatologically acceptable excipient is a salt.
  • Non-limiting example of a salt includes calcium chloride, magnesium chloride, magnesium sulfate, potassium chloride, potassium glycol sulfate, sodium chloride, or any combinations thereof.
  • the cosmetically or dermatologically acceptable excipient comprises an aliphatic alcohol. In some embodiments, the cosmetically or dermatologically acceptable excipient is an aliphatic alcohol.
  • Non-limiting example of an aliphatic alcohol includes aliphatic alcohol selected from: lauric acid, palmitic acid, stearic acid, arachidic alcohol, behenyl alcohol, cetearyl alcohol, cetyl alcohol, isocetyl alcohol, isostearyl alcohol, lauryl alcohol, myristyl alcohol, stearyl alcohol, C30-50 alcohols, lanolin alcohol, or any combinations thereof.
  • the cosmetically or dermatologically acceptable excipient comprises a perfuming ingredient.
  • the cosmetically or dermatologically acceptable excipient is a perfuming ingredient.
  • Non-limiting example of a perfuming ingredient include a fragrance such as limonene, hydroxycitronellol, benzyl salicylate, or hexyl cinnamal, or a combination of two or more thereof.
  • Solvents [0097] In some embodiments, the cleanser comprises a solvent.
  • the solvent comprises water, dimethyl isosorbide, triethyl citrate, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid/propanediol copolymer, lower alcohols containing from 1 to 6 carbon atoms, such as ethanol; polyols such as glycerin, glycols such as butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol, propanediol, WSGR Docket No.: 63230-729.601 isopentyldiol, polyethylene glycols such as PEG-8, sorbitol, sugars such as glucose, fructose, maltose, lactose, sucrose; or any combinations thereof.
  • the total concentration (%w/w) of the solvent in the cleanser is about 50% to about 99%. In some embodiments, the concentration (%w/w) of the solvent in a cleanser comprising one skin condition is about 50% to about 99%. In some embodiments, the concentration of each solvent in a cleanser comprising two or more solvent is about 50% to about 99%. In some embodiments, the concentration (%w/w) of the solvent in the cleanser is about 50% to about 99%. In some embodiments, the concentration of the solvent in the cleanser is about 50%, about 55%, about 60%, about 65%, 70%, about 75%, about 80%, about 85%, about 90%, about 99% and any values therebetween.
  • the concentration of the solvent in the cleanser is about 50% to about 90%, about 55% to about 85%, about 60% to about 80%, about 65% to about 80%, and about 70% to about 80%.
  • the concentration of the solvent can vary (e.g., variable) depending on the concentration of other components of the cleanser.
  • the concentration of the solvent when combined with the concentration of other components of the cleanser, yields 100% (%w/w).
  • Cleansers & Cleanser Compositions [0099]
  • the cleanser comprises: a solvent; a hair conditioner; a skin conditioner; a cleansing agent; a cosmetically or dermatologically acceptable excipient or a combination of two or more thereof.
  • the cleanser comprises: about 55% to about 85% (%w/w) of a solvent; about 0.20% to about 9% (%w/w) of a hair conditioner; about 0.01% to about 0.95% (%w/w) a skin conditioner; about 0.3% to about 18% (%w/w) a cleansing agent selected from: an anionic surfactant, an amphoteric surfactant, a non- WSGR Docket No.: 63230-729.601 ionic surfactant, a biosurfactant, and any combinations thereof; and about 0.5% to about 28.0% (%w/w) a cosmetically or dermatologically acceptable excipient selected from: preservatives, antioxidants, thickeners, chelating agents, co-solvents, sunscreen agents, vitamins, dyes, hair coloring agents, proteins, amino acids, organic polymers, natural extracts such as plant extracts, humectants, fragrances, perfumes, oils, emollients, lubric
  • the cleanser comprises: about 55% to about 85% (%w/w) of a solvent selected from: water, dimethyl isosorbide, triethyl citrate, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid/propanediol copolymer, lower alcohols containing from 1 to 6 carbon atoms, such as ethanol; polyols such as glycerin, glycols such as butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol, propanediol, isopentyldiol, polyethylene glycols such as PEG-8, sorbitol, sugars such as glucose, fructose, maltose, lactose, sucrose; and any combinations thereof; about 0.20% to about 9% (%w/w) of a hair conditioner selected from: panthenol, salicylic acid, WSGR Docket No
  • a cleanser comprising a solvent; a hair conditioner; a skin conditioner; a cleansing agent; a cosmetically or dermatologically acceptable excipient; or a combination of two or more thereof.
  • the cleanser comprises a hair conditioner described herein.
  • the concentration (%w/w) of the hair conditioner is the concentration of one hair conditioner.
  • the concentration (%w/w) of the hair conditioner is about 0.01% to about 10%.
  • the cleanser comprises a cleansing agent.
  • the cleansing agent is a surfactant.
  • the concentration (%w/w) of the cosmetically or dermatologically acceptable excipient is the concentration of one cosmetically or dermatologically acceptable excipient. In some embodiments, the concentration (%w/w) of the cosmetically or dermatologically acceptable excipient is about 0.1% to about 30%. In some embodiments, pH of the cleanser is about 4 and about 6. In some embodiments, the cleanser is a hair cleanser. In some embodiments, the cleanser is a skin cleanser. In some embodiments, the cleanser is a combination of a hair cleanser and a skin cleanser. In some embodiments, the cleanser cleanses hair. In some embodiments, the cleanser cleanses skin. In some embodiments, the cleanser cleanses both skin and hair.
  • a cleanser comprising a hair conditioner.
  • the concentration (%w/w) of the hair conditioner is about 0.01% to about 10%.
  • the cleanser further comprises a solvent; a skin conditioner; a cleansing agent; a cosmetically or dermatologically acceptable excipient; or a combination of two or more thereof.
  • the WSGR Docket No.: 63230-729.601 cleanser comprises a cleansing agent.
  • the cleansing agent is a surfactant.
  • the concentration (%w/w) of the cleansing agent is the concentration of one or more surfactants in the cleanser at about 0.1% to about 30%.
  • the concentration (%w/w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at about 0.1% to about 25%.
  • the cleanser comprises a skin conditioner described herein.
  • the concentration (%w/w) of the skin conditioner is the concentration of one skin conditioner.
  • the concentration (%w/w) of the skin conditioner is about 0.01% to about 5%.
  • the cleanser comprises a cosmetically or dermatologically acceptable excipient described herein.
  • the concentration (%w/w) of the cosmetically or dermatologically acceptable excipient is the concentration of one cosmetically or dermatologically acceptable excipient.
  • the concentration (%w/w) of the cosmetically or dermatologically acceptable excipient is about 0.1% to about 30%.
  • pH of the cleanser is about 4 and about 6.
  • the cleanser is a hair cleanser.
  • the cleanser is a skin cleanser.
  • the cleanser is a combination of a hair cleanser and a skin cleanser.
  • the cleanser cleanses hair.
  • the cleanser cleanses skin.
  • the cleanser cleanses both skin and hair.
  • the cleanser described herein comprises components of the ingredients of any one of Tables 1-13.
  • the cleanser described herein is a cleanser of Table 1.
  • the cleanser described herein is a cleanser of Table 2. In some embodiments, the cleanser described herein is a cleanser of Table 3. In some embodiments, the cleanser described herein is a cleanser of Table 4. In some embodiments, the cleanser described herein is a cleanser of Table 5. In some embodiments, the cleanser described herein is a cleanser of Table 6. In some embodiments, the cleanser described herein is a cleanser of Table 7. In some embodiments, the cleanser described herein is a cleanser of Table 8. In some embodiments, the cleanser described herein is a cleanser of Table 9. In some embodiments, the cleanser described herein is a cleanser of Table 10. In some embodiments, the cleanser described herein is a cleanser of Table 11.
  • the cleanser described herein is a cleanser of Table 12. Hair conditioner and skin conditioner WSGR Docket No.: 63230-729.601 [0107]
  • the cleanser described herein comprises a hair conditioner and a skin conditioner.
  • the cleanser comprises a hair conditioner, a skin conditioner, and at least one of: a cleansing agent; or a cosmetically or dermatologically acceptable excipient.
  • the cleanser comprises a hair conditioner, a skin conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient.
  • the cleanser comprises a hair conditioner, a skin conditioner, and a cleansing agent.
  • the cleanser comprises a hair conditioner, a skin conditioner, and a cosmetically or dermatologically acceptable excipient.
  • the pH of the cleanser is about 4 and about 6.
  • Table 1 illustrates non-limiting examples of the cleanser comprising: the hair conditioner and the skin conditioner; or the hair conditioner and the skin conditioner and at least one additional ingredient.
  • Table 1 Non-limiting examples of cleanser comprising hair conditioner and skin conditioner WSGR Docket No.: 63230-729.601 WSGR Docket No.: 63230-729.601 Hair conditioner and cleansing agents [0108]
  • the cleanser described herein comprises a hair conditioner and a cleansing agent.
  • the cleanser comprises a hair conditioner, a cleansing agent, and at least one of: a skin conditioner; or a cosmetically or dermatologically acceptable excipient.
  • the cleanser comprises a hair conditioner, a cleansing agent, a skin conditioner, and a cosmetically or dermatologically acceptable excipient.
  • the cleanser comprises a hair conditioner, a skin conditioner, and a cleansing agent.
  • the cleanser comprises a hair conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient.
  • the pH of the cleanser is about 4 and about 6. Table 2 illustrates non-limiting examples of the cleanser comprising: the hair conditioner and the cleansing agent; or the hair conditioner and the cleansing agent and at least one additional ingredient.
  • the cleanser described herein comprises a hair conditioner and a cosmetically or dermatologically acceptable excipient.
  • the cleanser comprises a hair conditioner, a cosmetically or dermatologically acceptable excipient, and at least one of: a skin conditioner; or a cleansing agent.
  • the cleanser comprises a hair conditioner, a cleansing agent, a skin conditioner, and a cosmetically or dermatologically acceptable excipient.
  • the cleanser comprises a hair conditioner, a skin conditioner, and a cosmetically or dermatologically acceptable excipient.
  • the cleanser comprises a hair conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient.
  • the pH of the cleanser is about 4 and about 6.
  • Tables 3-6 illustrate non-limiting examples of the cleanser comprising: the hair conditioner and the cosmetically or dermatologically acceptable excipient (e.g., buffering agent as shown in Table 3; chelating agent as shown in Table 4; humectant as shown in Table 5; and preservative as shown in Table 6); or the hair conditioner and the cosmetically or dermatologically acceptable excipients and at least one additional ingredient.
  • Non-limiting examples of cleanser comprising hair conditioner and buffering agent WSGR Docket No.: 63230-729.601 Hair conditioner and perfume [0109]
  • the cleanser described herein comprises a hair conditioner and perfume.
  • the cleanser comprises a hair WSGR Docket No.: 63230-729.601 conditioner, perfume, and at least one of: a skin conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient.
  • the cleanser comprises a hair conditioner, perfume, a skin conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient.
  • the cleanser comprises a hair conditioner, perfume, and a skin conditioner.
  • the cleanser comprises a hair conditioner, perfume, and a cleansing agent. In some embodiments, the cleanser comprises a hair conditioner, perfume, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the pH of the cleanser is about 4 and about 6. Table 7 illustrates non-limiting examples of the cleanser comprising: the hair conditioner and the perfume; or the hair conditioner and the perfume and at least one additional ingredient. Table 7.
  • Non-limiting examples of cleanser comprising hair conditioner and perfume WSGR Docket No.: 63230-729.601
  • the cleanser comprises: a solvent, a detoxifying agent, a hair conditioner, a skin conditioner, a cleansing agent, a cosmetically or dermatologically acceptable excipient, or a combination of two or more thereof.
  • the hair cleanser comprises: about 50% to about 90% (%w/w) of solvent; about 0.01% to about 10.0% (%w/w) of one or more hair WSGR Docket No.: 63230-729.601 conditioners; about 0.01% to about 5.0% (%w/w) one or more skin conditioners; about 0.01% to about 1.0% (%w/w) one or more detoxifying agents; about 0.1% to about 20% (%w/w) one or more cleansing agents; and about 0.1% to about 30% (%w/w) excipient.
  • the hair cleanser comprises: about 55% to about 85% (%w/w) of solvent; about 0.20% to about 9% (%w/w) of one or more hair conditioners; about 0.01% to about 0.95% (%w/w) one or more skin conditioners; about 0.05% to about 1.0% (%w/w) one or more detoxifying agents; about 0.3% to about 18% (%w/w) one or more cleansing agents; and about 0.5% to about 28.0% (%w/w) excipient.
  • the hair cleanser comprises: about 55% to about 85% (%w/w) of solvent; about 0.20% to about 9% (%w/w) of one or more hair conditioners; about 0.01% to about 0.95% (%w/w) one or more skin conditioners; about 0.05% to about 1.0% (%w/w) one or more detoxifying agents comprising an absorbent; about 0.3% to about 18% (%w/w) one or more cleansing agents selected from: an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, and any combinations thereof; and about 0.5% to about 28.0% (%w/w) excipient selected from: preservatives, antioxidants, thickeners, chelating agents, sunscreen agents, vitamins, dyes, hair coloring agents, proteins, amino acids, organic polymers, natural extracts such as plant extracts, humectants, fragrances, perfumes, oils, emollients, lubricants,
  • the hair cleanser comprises: about 55% to about 85% (%w/w) of solvent selected from: water, dimethyl isosorbide, triethyl citrate, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid/propanediol copolymer, lower alcohols containing from 1 to 6 carbon atoms, such as ethanol; polyols such as glycerin, glycols such as butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol, propanediol, isopentyldiol, polyethylene glycols such as PEG-8, sorbitol, sugars such as glucose, fructose, maltose, lactose, sucrose; and any combinations thereof; about 0.20% to about 9% (%w/w) of one or more hair conditioners selected from: panthenol, salicylic acid, sodium salicylate, car
  • the hair cleanser comprises: about 55% to about 85% (%w/w) of solvent selected from: water, dimethyl isosorbide, triethyl citrate, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid/propanediol copolymer, lower alcohols containing from 1 to 6 carbon atoms, such as ethanol; polyols such as glycerin, glycols such as butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol, propanediol, isopentyldiol, polyethylene glycols such as PEG-8, sorbitol, sugars such as glucose, fructose, maltose, lactose, sucrose; and any combinations thereof; about 0.20% to about 9% (%w/w) of one or more hair conditioners selected from: panthenol, salicylic acid, sodium salicylate, car
  • a cleanser comprising a solvent; a hair conditioner; a skin conditioner; a cleansing agent; a cosmetically or dermatologically acceptable excipient; or a combination of two or more thereof.
  • the cleanser comprises a hair conditioner described herein.
  • the concentration (%w/w) of the hair conditioner is the concentration of one hair conditioner.
  • the concentration (%w/w) of the hair conditioner is about 0.01% to about 10%.
  • the cleanser comprises a cleansing agent.
  • the cleansing agent is a surfactant.
  • the concentration (%w/w) of the cleansing agent is the concentration of one or more surfactants in the cleanser at about 0.1% to about 30%. In some embodiments, the concentration (%w/w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at about 0.1% to about 25%. In some embodiments, the cleanser comprises a skin conditioner described herein. In some embodiments, the concentration (%w/w) of the skin conditioner is the concentration of one skin conditioner. In some embodiments, the concentration (%w/w) of the skin conditioner is about 0.01% to about 5%. In some embodiments, the cleanser comprises a cosmetically or dermatologically acceptable excipient described herein.
  • the concentration (%w/w) of the cosmetically or dermatologically WSGR Docket No.: 63230-729.601 acceptable excipient is the concentration of one cosmetically or dermatologically acceptable excipient. In some embodiments, the concentration (%w/w) of the cosmetically or dermatologically acceptable excipient is about 0.1% to about 30%. In some embodiments, pH of the cleanser is about 4 and about 6. In some embodiments, the cleanser is a hair cleanser. In some embodiments, the cleanser is a skin cleanser. In some embodiments, the cleanser is a combination of a hair cleanser and a skin cleanser. In some embodiments, the cleanser cleanses hair. In some embodiments, the cleanser cleanses skin.
  • the cleanser described herein is a cleanser formulation of Table 4. In some embodiments, the cleanser described herein is a cleanser formulation of Table 5. In some embodiments, the cleanser described herein is a cleanser formulation of Table 6. In some embodiments, the cleanser described herein is a cleanser formulation of Table 7. In some embodiments, the cleanser described herein is a cleanser formulation of Table 8. In some embodiments, the cleanser described herein is a cleanser formulation of Table 9. Detoxifying agent and hair conditioner [0118] In some embodiments, the cleanser described herein comprises a detoxifying agent and a hair conditioner.
  • the cleanser comprises a detoxifying agent, a hair conditioner, a skin conditioner, a cleansing agent, and an excipient.
  • the cleanser comprises a detoxifying agent, a hair conditioner, a skin conditioner, and a cleansing agent.
  • the cleanser comprises a detoxifying agent, a hair conditioner, a skin conditioner, and an excipient.
  • the pH of the cleanser is about 2 to about 6. Table 9 illustrates non- limiting examples of the cleanser comprising: a detoxifying agent and a skin conditioner; or a detoxifying agent a skin conditioner, and at least one additional ingredient. Table 9.
  • Non-limiting examples of cleanser comprising detoxifying agent and skin conditioner WSGR Docket No.: 63230-729.601 WSGR Docket No.: 63230-729.601 Detoxifying agent and cleansing agent [0120]
  • the cleanser described herein comprises a detoxifying agent and a cleansing agent.
  • the cleanser comprises a detoxifying agent, a cleansing agent, and at least one of: a hair conditioner, a skin conditioner; or an excipient.
  • the cleanser comprises a detoxifying agent, a hair conditioner, a cleansing agent, a skin conditioner, and an excipient.
  • the cleanser comprises a detoxifying agent, a hair conditioner, a skin conditioner, and an excipient. In some embodiments, the cleanser comprises a detoxifying agent, a hair conditioner, a cleansing agent, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 11 illustrates non- limiting examples of the cleanser comprising: a detoxifying agent and a excipient; or a detoxifying agent, an excipient, and at least one additional ingredient. Table 11.
  • Non-limiting examples of cleanser comprising detoxifying agent and excipient WSGR Docket No.: 63230-729.601 WSGR Docket No.: 63230-729.601 Detoxifying agent and perfume [0122]
  • the cleanser described herein comprises a detoxifying agent and perfume.
  • the cleanser comprises a detoxifying agent, perfume, and at least one of: a hair conditioner, a skin conditioner; a cleansing agent; or an excipient.
  • the cleanser comprises a detoxifying agent, a hair conditioner, perfume, a skin conditioner, a cleansing agent, and an excipient.
  • the cleanser comprises a detoxifying agent, a hair conditioner, perfume, and a skin conditioner.
  • the cleanser comprises a detoxifying agent, a hair conditioner, perfume, and a cleansing agent. In some embodiments, the cleanser comprises a detoxifying agent, a hair conditioner, perfume, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 12 illustrates non- limiting examples of the cleanser comprising: a detoxifying agent and perfume; or a detoxifying agent, perfume, and at least one additional ingredient. Table 12.
  • Non-limiting examples of cleanser comprising detoxifying agent and perfume WSGR Docket No.: 63230-729.601 WSGR Docket No.: 63230-729.601 Conditioners Conditioner compositions
  • hair conditioner compositions comprising: a lipid nanoparticle comprising (e.g., encapsulating) a ceramide and vitamin E, which are useful for protecting hair from ultraviolet damage, mechanical stress damage, and/or environmental damage.
  • Conditioner compositions generally refer to and include compositions for treating hair or skin, including scalp, face, and body, in order to provide protection to hair or skin from mechanical, chemical, and/or environmental factors that contribute to damaged or weathered hair or skin, and/or to alleviate symptoms associated with such damage.
  • conditioner compositions can be distinguished from shampooing compositions by the lack of a surfactant in the conditioner composition.
  • Conditioner compositions further refer to and the conventional WSGR Docket No.: 63230-729.601 understanding of a hair conditioners (leave-in and/or rinse-out), being suitable for use on humans and/or animals.
  • conditioner compositions comprising a lipid nanoparticle, wherein the lipid nanoparticle comprises: (1) vitamin E or a derivative thereof; and (2) a ceramide.
  • conditioner compositions comprising a lipid nanoparticle (LNP) dispersion, wherein the lipid nanoparticle dispersion comprises: (1) a lipid nanoparticle; (2) vitamin E or a derivative thereof; and (3) a ceramide.
  • the lipid nanoparticle dispersion comprises a lipid nanoparticle comprising vitamin E or a derivative thereof and a ceramide.
  • Lipid nanoparticles generally refer to and include nanoscale-sized particles compose of lipids, e.g., ranging from 1 to 100 nanometers.
  • Lipids generally refer to and include molecules comprising one or more hydrophobic moieties or groups and optionally also comprising one or more hydrophilic moieties or groups.
  • Molecules comprising a hydrophobic portion and a hydrophilic portion are also commonly referred to as amphiphilic molecules.
  • amphiphilic compounds that may be included in an amphiphilic layer include, but are not limited to, phospholipids, aminolipids and sphingolipids.
  • the amphiphilic nature allows the molecules to self-assemble into organized structures and distinct phases (e.g., liposomes and/or vesicles).
  • One of those phases consists of lipid bilayers, as they are present in vesicles, multilamellar/unilamellar liposomes, or membranes in an aqueous environment.
  • Hydrophobicity can be imparted by the inclusion of non-polar groups including, but not limited to, long chain saturated and unsaturated aliphatic hydrocarbon groups and such groups substituted with one or more aromatic, alicyclic, or heterocyclic groups.
  • Hydrophilic groups can comprise polar and/or charged groups and include carbohydrates, phosphates, carboxyl groups, sulfates, amino groups, sulfhydryls, nitro groups, hydroxyl groups, and other similar groups.
  • the lipid nanoparticle is a liposome. In some embodiment the lipid nanoparticle is a lipid vesicle.
  • the lipid nanoparticle has an average particle size of about 100 nanometers (nm) to about 900 nm.
  • WSGR Docket No.: 63230-729.601 In certain embodiments, the lipid nanoparticle has an average particle size of about 100 nm to about 500 nm. In certain embodiments, the lipid nanoparticle has an average particle size of about 100 nm to about 400 nm. In certain embodiments, the lipid nanoparticle has an average particle size of about 100 nm to about 300 nm. In certain embodiments, the lipid nanoparticle has an average particle size of about 50 nm to about 350 nm.
  • the nanoparticle has an average particle size of about 100 nm to about 200 nm. In certain embodiments, the nanoparticle has an average particle size of about 200 nm to about 300 nm. In certain embodiments, the average particle size is measured by dynamic light scattering (DLS).
  • the lipid nanoparticle comprises one or more lipids. In certain embodiments, the one or more lipids are selected from: phospholipids, sterols, sphingolipids, glycolipids, or a combination thereof. In certain embodiments, the lipid nanoparticle comprises phospholipids.
  • the phospholipids comprise: neutrally charged phospholipids, cationic phospholipids, anionic phospholipids, or a combination thereof.
  • the phospholipids comprise: phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, phosphatidic acids, phosphatidylserines or sphingomyelin.
  • Such phospholipids include in particular diacylphosphatidylcholines, such as distearoylphosphatidylcholine (DSPC), dioleoylphosphatidylcholine (DOPC), dimyristoylphosphatidylcholine (DMPC), dipentadecanoylphosphatidylcholine, dilauroylphosphatidylcholine, dipalmitoylphosphatidylcholine (DPPC), diarachidoylphosphatidylcholine (DAPC), dibehenoylphosphatidylcholine (DBPC), ditricosanoylphosphatidylcholine (DTPC), dilignoceroylphatidylcholine (DLPC), palmitoyl-oleoyl-phosphatidylcholine (POPC) , 1,2-di-O-octadecenyl-sn-glycero-3-phosphorcholine (18:0 Diether PC), 1-ole
  • the lipid nanoparticle comprises a mixture of lipids.
  • the mixture of lipids is obtained from lecithin.
  • the lecithin is sourced from soybean, egg, milk, rapeseed, cottonseed, or sunflower, or a combination thereof.
  • Vitamin E or derivatives thereof generally refer to and include tocopherols, tocotrienols, and/or tocopheryl acetates. In some embodiments, Vitamin E or derivatives thereof comprise tocopherols, tocotrienols, and/or tocopheryl acetates.
  • Vitamin E or derivatives thereof comprise tocopherols and/or tocopheryl acetates.
  • the tocopherol is alpha-tocopherol.
  • the Vitamin E or derivatives thereof comprises tocopheryl acetate.
  • the Vitamin E or derivative thereof is present at a concentration ranging from 0.0005 to 0.01% total weight of the conditioner composition.
  • the Vitamin E or derivative thereof is present at a concentration ranging from 0.0005 to 0.005% total weight of the conditioner composition.
  • the Vitamin E or derivative thereof is present at a concentration ranging from 0.0001 to 0.001% total weight of the conditioner composition.
  • Ceramides generally refer to and include lipids chemically composed of a sphingoid base—a long-chain amino alcohol (long-chain base, e.g., C18-20)—and a fatty acid (e.g., C16-36) joined by an amide bond.
  • the sphingoid base generally consists of dihydrosphingosine (dS), sphingosine (S), phytosphingosine (P) or 6-hydroxy sphingosine (H).
  • the fatty acid may be a non-hydroxyl FA (N), an -hydroxyl FA (A), or anisate seed -hydroxyl FA (EO).
  • the ceramide is Cer 10. In certain embodiments, the ceramide is Cer 2. In certain embodiments, the ceramide is Cer 3. In certain embodiments, the ceramide is Cer 8. In certain embodiments, the ceramide is Cer 7. In certain embodiments, the ceramide is Cer 6. In certain embodiments, the ceramide is Cer 5. In certain embodiments, the ceramide is Cer 11. In certain embodiments, the ceramide is WSGR Docket No.: 63230-729.601 EOdS. In certain embodiments, the ceramide is Cer 1. In certain embodiments, the ceramide is Cer 9. In certain embodiments, the ceramide is Cer 4.
  • the ceramide is present at a concentration ranging from 0.0005 to 0.01% total weight of the conditioner composition. In certain embodiments, the ceramide is present at a concentration ranging from 0.001 to 0.01% total weight of the conditioner composition. In certain embodiments, the ceramide is present at a concentration ranging from 0.0025 to 0.01% total weight of the conditioner composition. In certain embodiments, the ceramide is present at a concentration ranging from 0.0025 to 0.0075% total weight of the conditioner composition. [0132] In some embodiments, the conditioner composition comprises the formulation of Table 13. Table 13. Non-limiting examples of conditioners provided herein. [0133] In some embodiments, the conditioner composition comprises the formulation of Table 14. Table 14. Non-limiting examples of conditioners provided herein.
  • Lipid nanoparticle dispersions generally refers to and includes a colloidal mixtures comprising lipid nanoparticles (e.g., liposomes).
  • the conditioner composition comprises the formulation of Table 15, wherein the formulation for the wt% by total weight of LNP Dispersion represents the LNP dispersion formulation before addition of the LNP dispersion to the conditioner composition. Table 15. Non-limiting examples of conditioners provided herein. WSGR Docket No.: 63230-729.601 [0135]
  • the conditioner composition comprises the formulation of Table 16, wherein the formulation for the% by total weight of LNP Dispersion represents the LNP dispersion formulation before addition of the LNP dispersion to the conditioner composition. Table 16.
  • the LNP dispersion further comprises a cationic polymer.
  • the cationic polymer is associated with the lipids (e.g., phospholipids) forming the liposome.
  • LNP dispersion comprises the formulation of Table 17 (e.g., before addition of the LNP dispersion to the conditioner composition). Table 17.
  • Non-limiting examples of conditioners provided herein. WSGR Docket No.: 63230-729.601
  • LNP dispersion comprises the formulation of Table 18 (e.g., before addition of the LNP dispersion to the conditioner composition). Table 18.
  • Table 18 e.g., before addition of the LNP dispersion to the conditioner composition.
  • the cationic polymer is a polymeric quaternary ammonium compound.
  • the polymeric quaternary ammonium compound is polyquaternium-4, -7, -11, -16, -22, or -67.
  • the polymeric quaternary ammonium compound is Polyquaternium-7.
  • the polymeric quaternary ammonium compound is Polyquaternium-11.
  • the polymeric quaternary ammonium compound is Polyquaternium- 22.
  • the polymeric quaternary ammonium compound is Polyquaternium-67.
  • the polymeric quaternary ammonium compound is Polyquaternium-4.
  • the lipid nanoparticle (e.g., liposome or vesicle) comprises one or more oils.
  • the one or more oils comprise: sweet almond oil, argan oil, coconut oil, jojoba oil, avocado oil, grapeseed oil, macadamia oil, sesame oil, or a combination thereof.
  • the lipid nanoparticle (e.g., liposome or vesicle) comprises two different oils.
  • the LNP dispersion comprises the formulation of Table 19 or Table 20 (e.g., before addition of the LNP dispersion to the conditioner composition). Table 19. Non-limiting examples of conditioners provided herein.
  • WSGR Docket No.: 63230-729.601 comprises a preservative.
  • LNP dispersion comprises the formulation of Table 21 (e.g., before addition of the LNP dispersion to the conditioner composition).
  • the preservative is phenoxyethanol. Table 21.
  • conditioners Non-limiting examples of conditioners provided herein.
  • Solvents generally refer to and include substances used to dissolve or disperse other ingredients in the formulation, contributing to the product’s overall consistency, stability, and performance. Solves can also include substances that dissolve solutes.
  • solvents in conditioners include but are not limited to water, alcohols (e.g., ethanol, isopropyl alcohol), glycols (e.g., propylene glycol, butylene glycol), silicones (e.g., dimethicone), esters (e.g., isopropyl palmitate, isopropyl myristate), and emollients (e.g., oils, fatty alcohols).
  • alcohols e.g., ethanol, isopropyl alcohol
  • glycols e.g., propylene glycol, butylene glycol
  • silicones e.g., dimethicone
  • esters e.g., isopropyl palmitate, isopropyl myristate
  • emollients e.g., oils, fatty alcohols
  • the conditioner composition comprises one or more solvents selected from water, alcohols (e.g., ethanol, isopropyl alcohol), glycols (e.g., propylene glycol, butylene glycol), silicones (e.g., dimethicone), WSGR Docket No.: 63230-729.601 esters (e.g., isopropyl palmitate, isopropyl myristate), and emollients (e.g., oils, fatty alcohols).
  • the conditioner composition comprises a solvent.
  • the composition comprises one or more solvents.
  • the solvent is water.
  • the conditioner composition comprises a solvent selected from: alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate.
  • the solvent comprises alcohols.
  • the solvent comprises dimethyl isosorbide.
  • the solvent comprises chlorotrifluoropropene.
  • the solvent comprises glycols.
  • the solvent comprises triethyl citrate.
  • the solvent other than water is present from 0.1% to 20% total weight of a conditioner composition. In certain embodiments, the solvent other than water is present from 0.5% to 10% total weight of a conditioner composition.
  • the solvent other than water is present from 1% to 10% total weight of a conditioner composition. In certain embodiments, the solvent other than water is present from 2% to 8% total weight of a conditioner composition. [0145] In certain embodiments, the solvent is present up to 0.1% total weight of a conditioner composition. In certain embodiments, the solvent is present up to 0.5% total weight of a conditioner composition. In certain embodiments, the solvent is present up to 1% total weight of a conditioner composition. In certain embodiments, the solvent is present up to 2.5% total weight of a conditioner composition. In certain embodiments, the solvent is present up to 5% total weight of a conditioner composition. In certain embodiments, the solvent is present up to 7.5% total weight of a conditioner composition.
  • the solvent is present up to 10% total weight of a conditioner composition. In certain embodiments, the solvent is present up to 12.5% total weight of a conditioner composition. In certain embodiments, the solvent is present up to 15% total weight of a conditioner composition. In certain embodiments, the solvent is present up to 20% total weight of a conditioner composition.
  • the conditioner composition comprises the formulation of Table 22 or Table 23. In certain embodiments, the conditioner composition comprises the formulation of Table 24 or Table 25. WSGR Docket No.: 63230-729.601 Table 22. Non-limiting examples of conditioners provided herein. Table 23. Non-limiting examples of conditioners provided herein. Table 24. Non-limiting examples of conditioners provided herein. Table 25.
  • the conditioner composition comprises an emulsifier.
  • the conditioner composition comprises one or more emulsifiers.
  • the one or more emulsifiers are selected from: fatty alcohol ethoxylates (e.g., ceteareth-20, ceteareth-25), sorbitan esters (e.g., sorbitan oleate, sorbitan stearate), PEG esters (e.g., PEG-40 hydrogenated castor oil, PEG-100 stearate), quaternary ammonium compounds (e.g., behentrimonium chloride), polyquaternium compounds (e.g., polyquaternium-10), ethoxylated sorbitan esters (e.g., polysorbate 20, polysorbate 80), glyceryl esters (e.g., glyceryl stearate), cationic surfactants (e.g., cetrimonium chloride), nonionic
  • the one or more emulsifiers is selected from lecithin, hydrogenated lecithin, phosphatidylcholine, [C12-16 alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl/capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate/stearate, polyglyceryl-3 bees
  • the emulsifier comprises caprylyl/capryl glucoside. In certain embodiments, the emulsifier comprises polyhydroxystearic acid. In certain embodiments, the emulsifier comprises phenethyl alcohol. In certain embodiments, the emulsifier comprises sodium surfactin. In certain embodiments, the emulsifier comprises polyglycerin-3. In certain embodiments, the emulsifier comprises polyglyceryl-3 distearate. In certain embodiments, the emulsifier comprises polyglyceryl-3 diisostearate. In certain embodiments, the emulsifier comprises polyglyceryl-3 cocoate.
  • the emulsifier comprises polyglyceryl-3 dicitrate/stearate. In certain embodiments, the emulsifier comprises polyglyceryl-3 beeswax. In certain embodiments, the emulsifier comprises polyglyceryl-3 polyricinoleate. In certain embodiments, the emulsifier comprises polyglyceryl-4 oleate. In certain embodiments, the emulsifier comprises polyglyceryl-4 caprate. In certain embodiments, the emulsifier comprises polylgylceryl-4 laurate. In certain embodiments, the emulsifier comprises polyglyceryl-6 caprylate. In certain embodiments, the emulsifier comprises polyglyceryl-6 stearate.
  • the emulsifier comprises polyglyceryl-6 distearate. In certain embodiments, the emulsifier comprises polyglyceryl-6 behenate. In certain embodiments, the emulsifier comprises polyglyceryl-6 polyhydroxystearate. In certain embodiments, the emulsifier comprises polyglyceryl-6 oleate. In certain embodiments, the emulsifier comprises polyglyceryl-6 ricinoleate. In certain embodiments, the emulsifier comprises polyglyceryl-6 polyricinoleate. In certain embodiments, the emulsifier comprises polyglyceryl-10 laurate.
  • the emulsifier comprises WSGR Docket No.: 63230-729.601 candelilla/jojoba/rice bran polyglyceryl-3 esters.
  • the emulsifier comprises stearoyl glutamic acid.
  • the emulsifier comprises stearyl alcohol.
  • the emulsifier comprises glyceryl stearate citrate.
  • the emulsifier comprises glyceryl oleate citrate.
  • the emulsifier comprises polyglyceryl-3 distearate.
  • the emulsifier comprises glyceryl stearate citrate.
  • the emulsifier comprises polyglyceryl-3 dicitrate/stearate. In certain embodiments, the emulsifier comprises candelilla/jojoba/rice bran polyglyceryl-3 esters. In certain embodiments, the emulsifier comprises polyglyceryl-6 stearate. In certain embodiments, the emulsifier comprises polyglyceryl-6 behenate. In certain embodiments, the emulsifier comprises polysorbate-20. In certain embodiments, the emulsifier comprises polyglyceryl-10 laurate. In certain embodiments, the emulsifier comprises polyglyceryl-6 caprylate. In certain embodiments, the emulsifier comprises polyglyceryl-3 cocoate.
  • the emulsifier comprises polyglyceryl-4 caprate. In certain embodiments, the emulsifier comprises polyglyceryl-6 ricinoleate. In certain embodiments, the emulsifier comprises polyglyceryl-6 caprylate. In certain embodiments, the emulsifier comprises sodium surfactin. In certain embodiments, the emulsifier comprises polyhydroxystearic acid. [0151] In some embodiments, the emulsifier is present from about 0.1% to about 20% total weight of a conditioner composition. In certain embodiments, the emulsifier is present from about 0.5% to about 10% total weight of a conditioner composition.
  • the emulsifier is present from about 2% to about 12% total weight of a conditioner composition. In certain embodiments, the emulsifier is present from about 2% to about 10% total weight of a conditioner composition. In certain embodiments, the emulsifier is present from about 1% to about 5% total weight of a conditioner composition. [0152] In certain embodiments, the emulsifier is present up to about 0.1% total weight of a conditioner composition. In certain embodiments, the emulsifier is present up to about 0.5% total weight of a conditioner composition. In certain embodiments, the emulsifier is present up to about 1% total weight of a conditioner composition.
  • the emulsifier is present up to about 20% total weight of a conditioner composition.
  • the conditioner composition comprises the formulation of Table 26 or Table 27.
  • the conditioner composition comprises the formulation of Table 28 or Table 29.
  • Table 26 Non-limiting examples of conditioners provided herein.
  • Table 27 Non-limiting examples of conditioners provided herein.
  • Table 28 Non-limiting examples of conditioners provided herein.
  • Conditioning agents generally refer to and include substances that enhance the texture, manageability, and overall feel of hair.
  • conditioning agents work by forming a thin film on the surface of the hair, reducing friction between individual strands, and helping to smooth the cuticle layer.
  • examples include but are not limited to: silicones (e.g., dimethicone), quaternary ammonium compounds (e.g., cetrimonium chloride, behentrimonium chloride), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol), natural oils (e.g., argan oil, coconut oil, jojoba oil), proteins (e.g., hydrolyzed keratin, silk proteins), humectants (e.g., glycerin, panthenol), polyquaternium compounds (e.g., polyquaternium-7, polyquaternium-10), cationic polymers (e.g., polyquaternium-16, polyquaternium-37), ceramides, and aloe vera.
  • silicones e.g., dimethicone
  • the conditioner composition comprises a conditioning agent.
  • the conditioner composition comprises one or more conditioning agents.
  • the one or more conditioning agents are selected from quaternium-18 bentonite, quaternium-22 hectonite, behentrimonium methosulfate, behentrimonium chloride, benzethonium chloride, benzalkonium chloride, cetrimonium chloride, cetrimonium methosulfate, steartrimonium chloride, stearalkonium chloride, dicetyldimonium chloride, tricetyldimonium chloride, cocotrimonium chloride, dicocodimonium chloride, laurtrimonium chloride, stearamidopropyl dimethylamine, PCA ethyl cocoyl arginate, C10-40 isoalkylamidopropylethyldimonium ethosulfate, dipalmitoylethyl hydroxyeth
  • the conditioning agent comprises quaternium-18 bentonite. In certain embodiments, the conditioning agent comprises quaternium-22 hectonite. In certain embodiments, the conditioning agent comprises behentrimonium methosulfate. In certain embodiments, the conditioning agent comprises behentrimonium chloride. In certain embodiments, the conditioning agent comprises benzethonium chloride. In certain embodiments, the conditioning agent comprises benzalkonium chloride. In certain embodiments, the conditioning agent comprises cetrimonium chloride. In certain embodiments, the conditioning agent comprises cetrimonium methosulfate. In certain embodiments, the conditioning agent comprises steartrimonium chloride. In certain embodiments, the conditioning agent comprises stearalkonium chloride.
  • the conditioning agent comprises dicetyldimonium chloride. In certain embodiments, the conditioning agent comprises tricetyldimonium chloride. In certain embodiments, the conditioning agent comprises cocotrimonium chloride. In certain embodiments, the conditioning agent comprises dicocodimonium chloride. In certain embodiments, the conditioning agent comprises laurtrimonium chloride. In certain embodiments, the conditioning agent comprises stearamidopropyl dimethylamine. In certain embodiments, the conditioning agent comprises PCA ethyl cocoyl arginate. In certain embodiments, the conditioning agent comprises C10-40 isoalkylamidopropylethyldimonium ethosulfate.
  • the conditioning agent comprises dipalmitoylethyl hydroxyethylmonium methosulfate. In certain embodiments, the conditioning agent comprises shea butter, amidopropyltrimonium chloride. In certain embodiments, the conditioning agent comprises quaternium-15. In certain embodiments, the conditioning agent comprises quaternium-18. In certain embodiments, the conditioning agent comprises quaternium- 87. In certain embodiments, the conditioning agent comprises polyquaternium-10. In certain embodiments, the conditioning agent comprises quaternium-22. In certain embodiments, the conditioning agent comprises polyquaternium-57. In certain embodiments, the conditioning agent comprises quaternary ammonium compounds.
  • the conditioning agent comprises cinnamidopropyltrimonium chloride. In certain embodiments, the conditioning agent comprises behentrimonium chloride. In certain embodiments, the conditioning agent comprises stearalkonium chloride. In certain embodiments, the conditioning agent comprises jojoba esters. In WSGR Docket No.: 63230-729.601 certain embodiments, the conditioning agent comprises hydroxypropyl guar hydroxypropyltrimonium chloride. [0157] In some embodiments, the conditioning agent is present from 0.1% to 20% total weight of a conditioner composition. In certain embodiments, the conditioning agent is present from 0.5% to 10% total weight of a conditioner composition.
  • the conditioning agent is present from about 1% (w/w) to about 10% (w/w) total weight of a conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 9% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 8% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 7% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 6% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 1% (w/w) to about 5% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 4% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 3% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 2% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 2% (w/w) to about 9% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 2% (w/w) to about 8% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 2% (w/w) to about 7% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 2% (w/w) to about 6% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 2% (w/w) to about 5% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 2% (w/w) to about 4% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 2% (w/w) to about 3% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 3% (w/w) to about 9% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from WSGR Docket No.: 63230-729.601 about 3% (w/w) to about 8% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 3% (w/w) to about 7% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 3% (w/w) to about 6% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 3% (w/w) to about 5% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 3% (w/w) to about 4% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent other than water is present from about 1% (w/w) to about 10% (w/w) total weight of a conditioner composition. In certain embodiments, the conditioning agent other than water is present from about 1% (w/w) to about 5% (w/w) total weight of a conditioner composition. In certain embodiments, the conditioning agent is present at about 1% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present at about 2% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present at about 3% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present at about 4% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present at about 5% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present at about 6% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present at about 7% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present at about 8% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present at about 9% (w/w) total weight of the conditioner composition. [0158] In certain embodiments, the conditioning agent is present up to about 0.1% total weight of a conditioner composition. In certain embodiments, the conditioning agent is present up to about 0.5% total weight of a conditioner composition. In certain embodiments, the conditioning agent is present up to about 1% total weight of a conditioner composition. In certain embodiments, the conditioning agent is present up to about 2% total weight of a conditioner composition. In certain embodiments, the conditioning agent is present up to about 3% total weight of a conditioner composition. In certain embodiments, the conditioning agent is present up to about 5% total weight of a conditioner composition.
  • the conditioning agent is present up WSGR Docket No.: 63230-729.601 to about 6% total weight of a conditioner composition. In certain embodiments, the conditioning agent is present up to about 10% total weight of a conditioner composition. In certain embodiments, the conditioning agent is present up to about 15% total weight of a conditioner composition. In certain embodiments, the conditioning agent is present up to about 20% total weight of a conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 20% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 15% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 1% (w/w) to about 10% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 9% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 8% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 7% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 6% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 1% (w/w) to about 5% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 1% (w/w) to about 4% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 2% (w/w) to about 20% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 2% (w/w) to about 15% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 2% (w/w) to about 10% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 2% (w/w) to about 9% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 2% (w/w) to about 8% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 2% (w/w) to about 7% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 2% (w/w) to about 6% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 2% (w/w) to about 5% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 2% (w/w) to about 4% WSGR Docket No.: 63230-729.601 (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 2% (w/w) to about 3% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 3% (w/w) to about 20% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 3% (w/w) to about 15% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 3% (w/w) to about 10% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 3% (w/w) to about 9% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 3% (w/w) to about 8% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 3% (w/w) to about 7% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 3% (w/w) to about 6% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 3% (w/w) to about 5% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 3% (w/w) to about 4% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 4% (w/w) to about 20% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 4% (w/w) to about 15% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 4% (w/w) to about 10% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 4% (w/w) to about 9% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 4% (w/w) to about 8% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 4% (w/w) to about 7% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 4% (w/w) to about 6% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 4% (w/w) to about 5% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 5% (w/w) to about 20% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 5% (w/w) to about 15% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 5% (w/w) to about 10% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 5% (w/w) to about 9% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 5% (w/w) to about 8% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 5% (w/w) to about 7% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 5% (w/w) to about 6% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 6% (w/w) to about 20% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 6% (w/w) to about 15% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 6% (w/w) to about 10% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 6% (w/w) to about 9% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 6% (w/w) to about 8% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 6% (w/w) to about 7% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 7% (w/w) to about 20% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 7% (w/w) to about 15% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 7% (w/w) to about 10% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 7% (w/w) to about 9% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 7% (w/w) to about 8% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 8% (w/w) to about 20% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 8% (w/w) to about 15% (w/w) total weight of the conditioner composition. In certain embodiments, the conditioning agent is present from about 8% (w/w) to about 10% (w/w) total weight of the conditioner composition.
  • the conditioning agent is present from about 8% (w/w) to about 9% (w/w) total weight of the conditioner composition.
  • the conditioner composition comprises the formulation of Table 30 or Table 31.
  • the conditioner composition comprises the formulation of Table 32 or Table 33. Table 30. Non-limiting examples of conditioners provided herein. Table 31. Non-limiting examples of conditioners provided herein. Table 32. Non-limiting examples of conditioners provided herein. WSGR Docket No.: 63230-729.601 Table 33. Non-limiting examples of conditioners provided herein.
  • the composition comprises one or more humectants.
  • the conditioner composition comprises one or more humectants selected from natural humectants such as glycerin, butylene glycol, propylene glycol, propanediol, isopentyldiol, and hydrolyzed proteins.
  • the conditioner composition comprises a humectant selected from: glycerin, butylene glycol, propylene glycol, propanediol, isopentyldiol, dipropylene glycol, pentylene glycol, mannitol, trehalose, xylitol, inositol, acetamidoethoxyethanol, phytosteryl-/isostearyl- /cetyl-/stearyl-/behenyl-dimer dilinoleate, isopentyldiol, or a combination thereof.
  • the humectant comprises glycerin.
  • the humectant comprises butylene glycol. In some embodiments, the humectant comprises propylene glycol. In some embodiments, the humectant comprises propanediol. In some embodiments, the humectant comprises isopentyldiol. In some embodiments, the humectant comprises dipropylene glycol. In some embodiments, the humectant comprises pentylene glycol. In some embodiments, the humectant comprises mannitol. In some embodiments, the humectant comprises trehalose. In some embodiments, the WSGR Docket No.: 63230-729.601 humectant comprises xylitol.
  • the humectant comprises inositol. In some embodiments, the humectant comprises acetamidoethoxyethanol. In some embodiments, the humectant comprises phytosteryl-/isostearyl-/cetyl-/stearyl-/behenyl- dimer dilinoleate. In some embodiments, the humectant comprises Isopentyldiol. [0162] In some embodiments, the humectant is present from 0.1% to 20% total weight of a conditioner composition. In certain embodiments, the humectant is present from 0.5% to 10% total weight of a conditioner composition.
  • the humectant is present from 1% to 10% total weight of a conditioner composition. In certain embodiments, the humectant other than water is present from 1% to 5% total weight of a conditioner composition. [0163] In certain embodiments, the humectant is present up to 0.1% total weight of a conditioner composition. In certain embodiments, the humectant is present up to 0.5% total weight of a conditioner composition. In certain embodiments, the humectant is present up to 1% total weight of a conditioner composition. In certain embodiments, the humectant is present up to 2% total weight of a conditioner composition. In certain embodiments, the humectant is present up to 3% total weight of a conditioner composition.
  • the humectant is present up to 5% total weight of a conditioner composition. In certain embodiments, the humectant is present up to 6% total weight of a conditioner composition. In certain embodiments, the humectant is present up to 10% total weight of a conditioner composition. In certain embodiments, the humectant is present up to 15% total weight of a conditioner composition. In certain embodiments, the humectant is present up to 20% total weight of a conditioner composition. [0164] In certain embodiments, the conditioner composition comprises the formulation of Table 34 or Table 35. In certain embodiments, the conditioner composition comprises the formulation of Table 36 or Table 37. Table 34. Non-limiting examples of conditioners provided herein.
  • the conditioner composition comprises one or more emollients selected from natural oils (e.g., coconut oil, argan oil, jojoba oil, olive oil), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol, cetearyl alcohol), silicones (e.g., dimethicone), natural butters (e.g., shea butter, cocoa butter), and synthetic esters (e.g., isopropyl palmitate, isopropyl myristate).
  • natural oils e.g., coconut oil, argan oil, jojoba oil, olive oil
  • fatty alcohols e.g., cetyl alcohol, stearyl alcohol, cetearyl alcohol
  • silicones e.g., dimethicone
  • natural butters e.g., shea butter, cocoa butter
  • synthetic esters e.g., isopropyl palmitate, isopropyl myristate
  • the conditioner composition comprises a emollient selected from: Phenethyl benzoate (dispersant/solubilizer), dicaprylyl maleate (solubilizer), dilinoleic acid/propanediol copolymer (solubilizer), isoamyl laurate (refatting + foam-improving), oleic acid, isohexadecane, squalane, isopropyl palmitate, s*polycitronellol, *diheptyl succinate, *capryloyl glycerin/sebacic acid copolymer, C12- 15 alkyl benzoate, caprylic/capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxy
  • the emollient comprises Triheptanoin. In certain embodiments, the emollient comprises Diisopropyl sebacate. In certain embodiments, the emollient comprises Diisopropyl adipate. In certain embodiments, the emollient comprises Propylene glycol dibenzoate. In certain embodiments, the emollient comprises WSGR Docket No.: 63230-729.601 Propoxytetramethyl piperidinyl dimethicone. In certain embodiments, the emollient comprises Castor oil/IPDI copolymer. In certain embodiments, the emollient comprises Butylene glycol cocoate.
  • the emollient comprises Isostearyl palmitate. In certain embodiments, the emollient comprises Isostearyl isostearate. In certain embodiments, the emollient comprises Cocoyl adipic acid/trimethylolpropane copolymer. In certain embodiments, the emollient comprises Pentaerythrityl stearate/caprate/caprylate/adipate. In certain embodiments, the emollient comprises Neopentyl glycol diethylhexanoate. In certain embodiments, the emollient comprises [Heavy] Pentaerythrityl tetraisostearate.
  • the emollient comprises Bis-behenyl/isostearyl/phytosteryl dimer dilinoleyl dimer dilinoleate. In certain embodiments, the emollient comprises Diisostearyl malate (DISM). In certain embodiments, the emollient comprises Polybutene [indopol]. In certain embodiments, the emollient comprises Polyisobutene. In certain embodiments, the emollient comprises Hydrogenated polyisobutene. In certain embodiments, the emollient comprises Hydrogenated polydecene. In certain embodiments, the emollient comprises [Light] *Isoamyl laurate.
  • the emollient comprises *Isoamyl cocoate. In certain embodiments, the emollient comprises *Hemisqualane. In certain embodiments, the emollient comprises *Polycitronellol acetate. In certain embodiments, the emollient comprises *Ethyl macadamiate. In certain embodiments, the emollient comprises *Coco-caprylate/caprate. In certain embodiments, the emollient comprises *Coconut alkanes. In certain embodiments, the emollient comprises *C9-12 alkane. In certain embodiments, the emollient comprises *C13-15 alkane.
  • the emollient comprises WSGR Docket No.: 63230-729.601 *C13-16 isoalkane (C13-16 isoparaffin).
  • the emollient comprises *Neopentyl glycol diheptanoate.
  • the emollient comprises *Hydrogenated ethylhexyl olivate.
  • the emollient comprises *Hydrogenated olive oil unsaponifiables.
  • the emollient comprises Undecane.
  • the emollient comprises Tridecane.
  • the emollient comprises Isododecane.
  • the emollient comprises one or more oils selected from: Olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesamum indicum (sesame) seed oil, prunus areniaca (apricot) kernel oil, crambe abyssinica seed oil, oryza sativa (rice) bran oil, vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, Isopropyl Palmitate, Isopropyl Palmitate.
  • oils selected from: Olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesamum indicum (sesame) seed oil, prunus areniaca (apricot) kernel oil, crambe abyssinica seed oil, oryza sativa (rice) bran oil, vitis vinifera (gra
  • the emollient is present up to about 1% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 2.5% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 5% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 7.5% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 10% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 12.5% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 15% total weight of a conditioner composition.
  • the pollution protectant comprises an exopolysaccharide (EPS).
  • EPS exopolysaccharide
  • Exopolysaccharides generally refer to and include long-chain polysaccharides comprising repeating units of sugars, mainly glucose, galactose and rhamnose, in different ratios.
  • the EPS comprises levan, gellan gum, dextran, xanthan gum, hyaluronic acid, Alteromonas Ferment Extract, or a combination thereof.
  • the exopolysaccharide comprises levan.
  • the exopolysaccharide comprises gellan gum.
  • the exopolysaccharide comprises dextran.
  • the conditioner composition comprises a solvent selected from: alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate.
  • the solvent comprises alcohols.
  • the solvent comprises dimethyl isosorbide.
  • the solvent comprises chlorotrifluoropropene.
  • the solvent comprises glycols.
  • the solvent comprises triethyl citrate.
  • the solvent has a viscosity that produces a calming or soothing feeling to the subject.
  • the pollution protectant and the lipid nanoparticle dispersion are present in a mass ratio of about 0.5:1 to about 5:1, about 0.6:1 to about 5:1, about 0.7:1 to about 5:1, about 0.8:1 to about 5:1, about 0.9:1 to about 5:1, about 1:1 to about 5:1, about 1.1:1 to about 5:1, about 1.2:1 to about 5:1, about 1.3:1 to about 5:1, about 1.4:1 to about 5:1, about 1.5:1 to about 5:1, about 1.6:1 to about 5:1, about 1.7:1 to about 5:1, about 1.8:1 to about 5:1, about 1.9:1 to about 5:1, about 2:1 to about 5:1, about 2.1:1 to about 5:1, about 2.2:1 to about 5:1, about 2.3:1 to about 5:1, about 2.4:1 to about 5:1, about 2.5:1 to about 5:1, about 2.6:1 to about 5:1, about 2.7:1 to about 5:1, about 2.8:1 to
  • the conditioner composition comprises the formulation of Table 42 or Table 43. In certain embodiments, the conditioner composition comprises the formulation of Table 44 or Table 45. Table 42. Non-limiting examples of conditioners provided herein. WSGR Docket No.: 63230-729.601 Table 43. Non-limiting examples of conditioners provided herein. Table 44. Non-limiting examples of conditioners provided herein. WSGR Docket No.: 63230-729.601 Table 45. Non-limiting examples of conditioners provided herein. Preservatives [0175] Preservatives generally refer to and include substances that help maintain the stability, safety, and efficacy of the conditioner throughout its shelf life and usage.
  • the conditioner composition comprises a preservative. In some embodiments, the conditioner composition comprises one or more preservatives.
  • the preservative is present up to about 3% total weight of a conditioner composition. In certain embodiments, the preservative is present up to about 4% total weight of a conditioner composition. In certain embodiments, the preservative is present up to about 5% total weight of a conditioner composition.
  • the conditioner composition comprises the formulation of Table 46 or Table 47. In certain embodiments, the conditioner composition comprises the formulation of Table 48 or Table 49. Table 46. Non-limiting examples of conditioners provided herein. Table 47. Non-limiting examples of conditioners provided herein. Table 48. Non-limiting examples of conditioners provided herein. WSGR Docket No.: 63230-729.601 Table 49.
  • pH modifiers generally refer to and include substances that help maintain the stability, safety, and efficacy of the conditioner throughout its shelf life and usage. Examples include but are not limited to: citric acid, sodium hydroxide, triethanolamine WSGR Docket No.: 63230-729.601 (TEA), lactic acid, phosphoric acid, sodium citrate, potassium hydroxide, and glycolic acid as pH modifiers in conditioners.
  • the conditioner composition comprises a pH modifier. In some embodiments, the conditioner composition comprises one or more pH modifiers.
  • the pH modifier is selected from: citric acid, sodium hydroxide, triethanolamine (TEA), lactic acid, phosphoric acid, sodium citrate, potassium hydroxide, and glycolic acid.
  • the pH modifier is selected from: citric acid, lactic acid, glycolic acid, tartaric acid, malic acid, gluconic acid, glucuronic acid, azelaic acid, acetic acid, sodium hydroxide, triethanolamine, and L-arginine.
  • the pH modifier comprises citric acid.
  • the pH modifier comprises lactic acid.
  • the pH modifier comprises glycolic acid.
  • the pH modifier comprises tartaric acid.
  • the pH modifier is present from about 0.5% to about 2% total weight of a conditioner composition. In certain embodiments, the pH modifier is present from about 0.5% to about 1.5% total weight of a conditioner composition. [0184] In certain embodiments, the pH modifier is present up to about 0.05% total weight of a conditioner composition. In certain embodiments, the pH modifier is present up to about 0.1% total weight of a conditioner composition. In certain embodiments, the pH modifier is present up to about 0.5% total weight of a conditioner composition. In certain embodiments, the pH modifier is present up to about 0.75% total weight of a conditioner composition. In certain embodiments, the pH modifier is present up to about 1% total weight of a conditioner composition.
  • the pH modifier is present up to about 1.5% total weight of a conditioner composition. In certain embodiments, the pH modifier is present up to about 2% total weight of a conditioner WSGR Docket No.: 63230-729.601 composition. In certain embodiments, the pH modifier is present up to about 2.5% total weight of a conditioner composition.
  • the pH of the conditioner composition is about 4 and about 8. In some embodiments, the pH of the conditioner composition is about 4 and about 7.In some embodiments, the pH of the conditioner composition is about 4 and about 6. In some embodiments, the pH of the conditioner composition is about 5 and about 8. In some embodiments, the pH of the conditioner composition is about 5 and about 7. In some embodiments, the pH of the conditioner composition is about 5 and about 6.
  • the conditioner composition comprises the formulation of Table 50 or Table 51. In certain embodiments, the conditioner composition comprises the formulation of Table 52 or Table 53. Table 50. Non-limiting examples of conditioners provided herein. Table 51. Non-limiting examples of conditioners provided herein. WSGR Docket No.: 63230-729.601 Table 52. Non-limiting examples of conditioners provided herein. Table 53. Non-limiting examples of conditioners provided herein. WSGR Docket No.: 63230-729.601 Antioxidants [0187] Antioxidants generally refer to and include ingredients that role in protecting the hair from damage caused by free radicals.
  • antioxidants include but are not limited to Vitamins (e.g., Vitamin E, Vitamin C), Polyphenols (e.g., Green Tea Extract, Grapeseed Extract), Flavonoids (e.g., Chamomile Extract), Carotenoids (e.g., Beta-Carotene), Fatty Acids and Oils (e.g., Argan Oil, coconut Oil), Enzymes (e.g., Superoxide Dismutase), Ubiquinone (e.g., Coenzyme Q10), Ascorbic Acid (e.g., Vitamin C), and Ferulic Acid.
  • the conditioner composition comprises an antioxidant.
  • the conditioner composition comprises one or more antioxidants.
  • the conditioner composition comprises one or more antioxidants selected from Vitamins (e.g., Vitamin E, Vitamin C), Polyphenols (e.g., Green Tea Extract, Grapeseed Extract), Flavonoids (e.g., Chamomile Extract), Carotenoids (e.g., Beta-Carotene), Fatty Acids and Oils (e.g., Argan Oil, coconut Oil), Enzymes (e.g., Superoxide Dismutase), Ubiquinone (e.g., Coenzyme Q10), Ascorbic Acid (e.g., Vitamin C), and Ferulic Acid.
  • Vitamins e.g., Vitamin E, Vitamin C
  • Polyphenols e.g., Green Tea Extract, Grapeseed Extract
  • Flavonoids e.g., Chamomile Extract
  • Carotenoids e.g., Beta-Carotene
  • Fatty Acids and Oils e.g., Argan Oil, coconut Oil
  • Enzymes e.g., Superoxide Dismut
  • the conditioner composition comprises one or more antioxidants selected from a group that includes Tocopheryl acetate, ascorbic acid, carnosine, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, daucus carota sativa root cell culture lysate, monoammonium glycyrrhizinate, alpha-lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus officinalis (rosemary) leaf extract (WS), vitis vinifera (grape) seed extract, camellia sinensis leaf extract, quercus robur wood extract, hydrolyzed olive fruit, olea europea (olive) leaf extract, oleuropin, punica granatum bark/fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin (EGCG), tannins, sulforaphane, re
  • the antioxidant comprises Tocopheryl acetate. In certain embodiments, the antioxidant comprises ascorbic acid. In certain embodiments, the antioxidant comprises carnosine. In certain embodiments, the antioxidant comprises tetrahexyldecyl ascorbate. In certain embodiments, the antioxidant comprises WSGR Docket No.: 63230-729.601 bioflavonoids. In certain embodiments, the antioxidant comprises lycopene. In certain embodiments, the antioxidant comprises daucus carota sativa root cell culture lysate. In certain embodiments, the antioxidant comprises monoammonium glycyrrhizinate. In certain embodiments, the antioxidant comprises alpha-lipoic acid (thioctic acid).
  • the antioxidant comprises Leontopodium alpinum (edelweiss) extract. In certain embodiments, the antioxidant comprises Rosmarinus officinalis (rosemary) leaf extract (WS). In certain embodiments, the antioxidant comprises Vitis vinifera (grape) seed extract. In certain embodiments, the antioxidant comprises Camellia sinensis leaf extract. In certain embodiments, the antioxidant comprises Quercus robur wood extract. In certain embodiments, the antioxidant comprises hydrolyzed olive fruit. In certain embodiments, the antioxidant comprises Olea europea (olive) leaf extract. In certain embodiments, the antioxidant comprises oleuropin. In certain embodiments, the antioxidant comprises Punica granatum bark/fruit extract. In certain embodiments, the antioxidant comprises punicalagin.
  • the antioxidant comprises ellagic acid. In certain embodiments, the antioxidant comprises polyphenols. In certain embodiments, the antioxidant comprises epigallocatechin (EGCG). In certain embodiments, the antioxidant comprises tannins. In certain embodiments, the antioxidant comprises sulforaphane. In certain embodiments, the antioxidant comprises resveratrol. In certain embodiments, the antioxidant comprises nordihydroguaiaretic acid. [0189] In some embodiments, the antioxidant is present from about 0.01% to about 5% total weight of a conditioner composition. In certain embodiments, the antioxidant is present from about 0.1% to about 2% total weight of a conditioner composition. In certain embodiments, the antioxidant is present from about 0.5% to about 2% total weight of a conditioner composition.
  • the antioxidant is present from about 0.5% to about 1.5% total weight of a conditioner composition. In certain embodiments, the antioxidant is present from about 1% to about 5% total weight of a conditioner composition. [0190] In certain embodiments, the antioxidant is present up to about 0.05% total weight of a conditioner composition. In certain embodiments, the antioxidant is present up to about 0.1% total weight of a conditioner composition. In certain embodiments, the antioxidant is present up to about 0.5% total weight of a conditioner composition. In certain embodiments, the antioxidant is present up to about 0.75% total weight of a conditioner composition. In certain embodiments, the antioxidant is present up to about 1% total weight of a conditioner composition.
  • the antioxidant is WSGR Docket No.: 63230-729.601 present up to about 1.5% total weight of a conditioner composition. In certain embodiments, the antioxidant is present up to about 2% total weight of a conditioner composition. In certain embodiments, the antioxidant is present up to about 2.5% total weight of a conditioner composition. In certain embodiments, the antioxidant is present up to about 3% total weight of a conditioner composition. In certain embodiments, the antioxidant is present up to about 4% total weight of a conditioner composition. In certain embodiments, the antioxidant is present up to about 5% total weight of a conditioner composition.
  • Fixatives generally refer to and include ingredients that help maintain the fragrance in a product and on the hair for an extended period.
  • the conditioner composition comprises a fixative (e.g., a fixative polymer).
  • the conditioner composition comprises one or more fixatives.
  • the fixative comprises one or more fixatives selected from: Polyacrylamidomethylpropane sulfonic acid, octylacrylamide/acrylates/butyl-aminoethyl methacrylate copolymer, vinyl caprolactam/VP/dimethylaminoethyl methacrylate copolymer, and/or polyurethane-48.
  • the fixative comprises Polyacrylamido-methylpropane sulfonic acid. In certain embodiments, the fixative comprises Octylacrylamide/Acrylates/Butylaminoethyl Methacrylate Copolymer. In certain embodiments, the fixative comprises Vinyl Caprolactam/VP/Dimethylaminoethyl Methacrylate Copolymer. In certain embodiments, the fixative comprises Polyurethane- 48. [0193] In some embodiments, the fixative is present from about 0.01% to about 2% total weight of a conditioner composition. In certain embodiments, the fixative is present from about 0.1% to about 2% total weight of a conditioner composition.
  • the fixative is present from about 0.5% to about 2% total weight of a conditioner composition. In certain embodiments, the fixative is present from about 0.5% to about 1.5% total weight of a conditioner composition. [0194] In certain embodiments, the fixative is present up to about 0.05% total weight of a conditioner composition. In certain embodiments, the fixative is present up to about 0.1% total weight of a conditioner composition. In certain embodiments, the fixative is WSGR Docket No.: 63230-729.601 present up to about 0.5% total weight of a conditioner composition. In certain embodiments, the fixative is present up to about 0.75% total weight of a conditioner composition. In certain embodiments, the fixative is present up to about 1% total weight of a conditioner composition.
  • the fixative is present up to about 1.5% total weight of a conditioner composition. In certain embodiments, the fixative is present up to about 2% total weight of a conditioner composition. In certain embodiments, the fixative is present up to about 2.5% total weight of a conditioner composition.
  • Heat Protectants generally refer to and include ingredients designed to shield the hair from damage caused by the application of heat (e.g., in heat styling tools such as flat irons, curling irons, and blow dryers). In certain instances, heat protectants create a protective barrier on the hair strands to minimize the negative effects of high temperatures.
  • heat protectants include but are not limited to: dimethicone, amodimethicone, polyquaternium-4, polyquaternium-10, panthenol (Pro-Vitamin B5), cationic polymers like cetrimonium chloride or behentrimonium chloride, hydrolyzed proteins such as hydrolyzed wheat protein or hydrolyzed keratin, and quaternium-70.
  • the conditioner composition comprises one or more heat protectants selected from: dimethicone, amodimethicone, polyquaternium-4, polyquaternium-10, panthenol (Pro-Vitamin B5), cationic polymers like cetrimonium chloride or behentrimonium chloride, hydrolyzed proteins such as hydrolyzed wheat protein or hydrolyzed keratin, and quaternium-70.
  • the heat protectant comprises sodium methoxy peg-16 maleate/styrene sulfonate copolymer.
  • the heat protectant comprises panthenyl hydroxypropyl steardimonium chloride.
  • the heat protectant is present from about 0.01% to about 2% total weight of a conditioner composition. In certain embodiments, the heat protectant is present from about 0.1% to about 2% total weight of a conditioner composition. In certain embodiments, the heat protectant is present from about 0.5% to about 2% total weight of a conditioner composition. In certain embodiments, the heat protectant is present from about 0.5% to about 1.5% total weight of a conditioner composition.
  • WSGR Docket No.: 63230-729.601 [0198] In certain embodiments, the heat protectant is present up to about 0.05% total weight of a conditioner composition. In certain embodiments, the heat protectant is present up to about 0.1% total weight of a conditioner composition.
  • the heat protectant is present up to about 0.5% total weight of a conditioner composition. In certain embodiments, the heat protectant is present up to about 0.75% total weight of a conditioner composition. In certain embodiments, the heat protectant is present up to about 1% total weight of a conditioner composition. In certain embodiments, the heat protectant is present up to about 1.5% total weight of a conditioner composition. In certain embodiments, the heat protectant is present up to about 2% total weight of a conditioner composition. In certain embodiments, the heat protectant is present up to about 2.5% total weight of a conditioner composition.
  • Fatty Acids and Fatty Alcohols generally refer to and include ingredients found in hair conditioners, and they serve various purposes to enhance the performance and benefits of the product (e.g., by having emollient, moisturizing, and/or conditioning properties).
  • fatty acids include but are not limited to: oleic acid, linoleic acid, palmitic acid, stearic acid, and myristic acid.
  • fatty alcohols include but are not limited to: cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, and lauryl alcohol.
  • the conditioner composition comprise a fatty acid.
  • the conditioner composition comprised one or more fatty acids.
  • the fatty acid is selected from: oleic acid, linoleic acid, palmitic acid, stearic acid, and myristic acid.
  • the conditioner composition comprise a fatty alcohol.
  • the conditioner composition comprises one or more fatty alcohols.
  • the fatty alcohol is selected from: cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, and lauryl alcohol.
  • the fatty acid and/or fatty alcohol is selected from: lauric acid, lauryl alcohol, palmitic acid, cetyl alcohol, stearic acid, stearyl alcohol, cetearyl alcohol, and/or behenyl alcohol, arachidic alcohol.
  • the fatty acid or fatty alcohol is present from 0.1% to 20% total weight of a conditioner composition. In certain embodiments, the fatty acid or fatty alcohol is present from 0.5% to 10% total weight of a conditioner composition. In certain embodiments, the fatty acid or fatty alcohol is present from 1% to 10% total WSGR Docket No.: 63230-729.601 weight of a conditioner composition.
  • the fatty acid or fatty alcohol other than water is present from 1% to 5% total weight of a conditioner composition.
  • the fatty acid or fatty alcohol is present up to 0.1% total weight of a conditioner composition. In certain embodiments, the fatty acid or fatty alcohol is present up to 0.5% total weight of a conditioner composition. In certain embodiments, the fatty acid or fatty alcohol is present up to 1% total weight of a conditioner composition. In certain embodiments, the fatty acid or fatty alcohol is present up to 2% total weight of a conditioner composition. In certain embodiments, the fatty acid or fatty alcohol is present up to 3% total weight of a conditioner composition.
  • the fatty acid or fatty alcohol is present up to 5% total weight of a conditioner composition. In certain embodiments, the fatty acid or fatty alcohol is present up to 6% total weight of a conditioner composition. In certain embodiments, the fatty acid or fatty alcohol is present up to 10% total weight of a conditioner composition.
  • Waxes generally refer to and include lipophilic substances derived from natural sources or synthetic. Examples of waxes include but are not limited to: beeswax, candelilla wax, carnauba wax, microcrystalline wax, ozokerite, montan wax, polyethylene wax, paraffin wax, and synthetic waxes. [0204] In some embodiments, the conditioner composition comprises a wax.
  • the wax is selected from: beeswax, candelilla wax, carnauba wax, microcrystalline wax, ozokerite, montan wax, polyethylene wax, paraffin wax, and synthetic waxes.
  • the wax is selected from: helianthus annuus (sunflower) seed wax and acacia decurrens flower wax.
  • the wax is present from about 0.1% wt to about 20% wt of a total weight of a conditioner composition. In certain embodiments, the wax is present from about 0.5% wt to about 10% wt of a total weight of a conditioner composition.
  • the wax is present from about 2% wt to about 12% wt of the total weight of a conditioner composition. In certain embodiments, the wax is present from about 5% wt% to about 15% wt of the total weight of a conditioner composition. [0206] In some embodiments, the wax is present from about 0.1% to about 10% total weight of a conditioner composition. In certain embodiments, the wax is present from WSGR Docket No.: 63230-729.601 about 0.5% to about 5% total weight of a conditioner composition. In certain embodiments, the wax is present from about 0.5% to about 2% total weight of a conditioner composition. [0207] In certain embodiments, the wax is present up to about 0.1% total weight of a conditioner composition.
  • the wax is present up to about 0.5% total weight of a conditioner composition. In certain embodiments, the wax is present up to about 1% total weight of a conditioner composition. In certain embodiments, the wax is present up to about 2.5% total weight of a conditioner composition. In certain embodiments, the wax is present up to about 5% total weight of a conditioner composition. In certain embodiments, the wax is present up to about 7.5% total weight of a conditioner composition. In certain embodiments, the wax is present up to about 10% total weight of a conditioner composition. Additional Agents [0208] In some embodiments, the conditioner composition comprises an additional agent. In some embodiments, the composition comprises one or more additional agents.
  • the additional agent comprises a conditioning and emollient blend, additional hair-conditioning agents, film-forming agents, skin-conditioning agents, moisturizing agents, additional UV absorbers, viscosity-controlling agents, and additional fixatives.
  • these include but are not limited to ingredients such as Brassica Alcohol, Brassicyl Valinate Esylate, Brassicyl Isoleucinate Esylate, Bis- Ethyl(Isostearylimidazoline) Isostearamide, Sarcosine, Arginine PCA, Glycolipids, Glycosphingolipids, Panthenol, Carthamus Tinctorius (Safflower) Seed Extract, Polysilicone-29, Sphinganine, Phytantriol, Hydrolyzed Adansonia Digitata Seed Extract, Hydrolyzed Quinoa, Hydrolyzed Rice Protein, Hydrolyzed Soy Protein, Hydrolyzed Vegetable Protein, Hydrolyzed Corn Starch, Behenyl/Stearyl Aminopropanedi
  • the additional agent comprises Brassica alcohol. In certain embodiments, the additional agent comprises Brassicyl valinate esylate. In certain embodiments, the additional agent comprises Brassicyl isoleucinate esylate. In certain WSGR Docket No.: 63230-729.601 embodiments, the additional agent comprises Bis-ethyl(isostearylimidazoline) isostearamide. In certain embodiments, the additional agent comprises Sarcosine. In certain embodiments, the additional agent comprises Arginine PCA. In certain embodiments, the additional agent comprises Glycolipids. In certain embodiments, the additional agent comprises Glycosphingolipids. In certain embodiments, the additional agent comprises Panthenol.
  • the additional agent comprises Carthamus tinctorius (safflower) seed extract. In certain embodiments, the additional agent comprises Polysilicone-29. In certain embodiments, the additional agent comprises Sphinganine. In certain embodiments, the additional agent comprises Phytantriol. In certain embodiments, the additional agent comprises Hydrolyzed Adansonia digitata seed extract. In certain embodiments, the additional agent comprises Hydrolyzed Quinoa. In certain embodiments, the additional agent comprises Hydrolyzed Rice Protein. In certain embodiments, the additional agent comprises Hydrolyzed Soy Protein. In certain embodiments, the additional agent comprises Hydrolyzed Vegetable Protein. In certain embodiments, the additional agent comprises Hydrolyzed Corn Starch.
  • the additional agent comprises Behenyl/Stearyl Aminopropanediol Esters. In certain embodiments, the additional agent comprises Cystine bis-PG-Propyl Silanetriol. In certain embodiments, the additional agent comprises Polyquaternium-57. In certain embodiments, the additional agent comprises Polyquaternium-59. In certain embodiments, the additional agent comprises Polyimide-1. In certain embodiments, the additional agent comprises Polyurethane-35. In certain embodiments, the additional agent comprises PVM/MA Copolymer. In certain embodiments, the additional agent comprises Dicetyldimonium Chloride. In certain embodiments, the additional agent comprises Stearamidopropyl Dimethylamine.
  • the additional agent comprises C10-40 Isoalkylamidopropylethyldimonium Ethosulfate. In certain embodiments, the additional agent comprises SH-Polypeptide-3. In certain embodiments, the additional agent comprises Linum usitatissimum (linseed) extract. In certain embodiments, the additional agent comprises Salvia hispanica seed extract. In certain embodiments, the additional agent comprises Astrocaryum murumuru fruit extract. In certain embodiments, the additional agent comprises Orbignya speciosa kernel oil. In certain embodiments, the additional agent comprises Moringa oleifera seed extract. In certain embodiments, the additional agent comprises Cinnamidopropyltrimonium Chloride.
  • the additional agent comprises Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract. In certain embodiments, the additional agent comprises one or more extracts selected from: Glycine soja (Soybean) Seed Extract, Elaeis Guineensis (Palm) Fruit Extract, Oryza Sativa (Rice) Extract, and/or Soybean Glycerides. In certain embodiments, the additional agent comprises Butyrospermum Parkii (Shea) Butter Unsaponifiables. In certain embodiments, the additional agent comprises Hydrolyzed Chestnut Extract. In certain embodiments, the additional agent comprises Glyceryl Rosinate. In certain embodiments, the additional agent comprises Shorea Robusta Resin.
  • the conditioner composition comprises a rheology modifier. In some embodiments, the conditioner composition comprises one or more rheology modifiers.
  • administering the composition reduces hair breakage of hair treated with the composition (e.g., conditioner composition) relative to hair not treated with the composition by about 5%, about 10%, about 15%, about 20%, about 25%, about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, about 95%, about 96%, about 97%, about 98%, about 99%, or about 100%.
  • the term “individual” is synonymous with patient and/or subject and includes and/or refers to a human and may be a human that has been diagnosed as needing to treat a disease or condition as disclosed herein. However, examples are not limited to humans and include, chimpanzees, marmosets, cows, horses, sheep, goats, pigs, rabbits, dogs, cats, rats, mice, guinea pigs, and the like.
  • the individual is typically a human and may be a human that has been diagnosed as needing to treat a disease or condition as disclosed herein.
  • the term “cosmetically acceptable” refers to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problems or complications commensurate with a reasonable benefit/risk ratio.
  • the term “cosmetically or dermatologically acceptable” refers to the compositions or components described are suitable for use in contact with human skin tissue without undue toxicity, incompatibility, instability, allergic response, and the like.
  • Embodiment 2 The conditioner composition of embodiment 2, wherein the Vitamin E or derivative thereof is present at 0.1 to 1% by total weight of the LNP dispersion.
  • Embodiment 4. The conditioner composition of any one of embodiments 2-3, wherein the ceramide is present at 0.5 to 5% by total weight of the LNP dispersion.
  • Embodiment 5. The conditioner composition of any one of embodiments 3-4, wherein the % by total weight of the LNP dispersion is a measure independent from a% by total weight of the conditioner composition.
  • Embodiment 6. The conditioner composition of any one of embodiments 2-5, wherein the LNP dispersion is present at 0.01 to 5% by total weight of the conditioner composition.
  • Embodiment 11 The conditioner composition of embodiment 10, wherein the vitamin E or derivative thereof consists of tocopheryl acetate.
  • Embodiment 12 The conditioner composition of any one of embodiments 1- 11, wherein the vitamin E or derivative thereof is present at 0.0005 to 0.05% by total weight of the conditioner composition.
  • Embodiment 13 The conditioner composition of any one of embodiments 1- 12, wherein the vitamin E or derivative thereof is present at 0.0005 to 0.005% by total weight of the conditioner composition.
  • Embodiment 14 The conditioner composition of any one of embodiments 1- 13, wherein the vitamin E or derivative thereof is present at about 0.00125% by total weight of the conditioner composition.
  • the conditioner composition of any one of embodiments 1- 14, wherein the ceramide comprises: Ceramide (Cer) 10, Cer 2, Cer 3, Cer 8, Cer 7, Cer 6, Cer 5, Cer 11, EOdS, Cer 1, Cer 9, or Cer 4.
  • Embodiment 16 The conditioner composition of any one of embodiments 1- 15, wherein the ceramide comprises Cer 3.
  • Embodiment 17 The conditioner composition of any one of embodiments 1- 16, wherein the ceramide is present at 0.0025 to 0.05% by total weight of the conditioner composition.
  • Embodiment 18 The conditioner composition of any one of embodiments 1- 17, wherein the ceramide is present at 0.0025 to 0.015% by total weight of the conditioner composition.
  • Embodiment 20 The conditioner composition of any one of embodiments 1- 19, wherein the conditioner composition comprises any one of the formulations in Table 13 or Table 14.
  • Embodiment 21 The conditioner composition of any one of embodiments 1- 20, wherein the conditioner composition comprises any one of the formulations in Table 15 or Table 16.
  • Embodiment 22 The conditioner composition of any one of embodiments 1- 21, wherein the lipid nanoparticle is a liposome.
  • Embodiment 24 The conditioner composition of any one of embodiments 1- 22, wherein the conditioner composition further comprises a cationic polymer.
  • Embodiment 24 The conditioner composition of embodiment 23, wherein the cationic polymer is associated with lipids of the lipid nanoparticle.
  • Embodiment 25 The conditioner composition of embodiment 24, wherein the cationic polymer comprises a polymeric quaternary ammonium compound.
  • Embodiment 26 The conditioner composition of embodiment 25, wherein the polymeric quaternary ammonium compound comprises polyquaternium-4, -7, -11, -16, - 22, or -67
  • Embodiment 27 The conditioner composition of embodiment 26, wherein the polymeric quaternary ammonium compound is polyquaternium-16.
  • Embodiment 28 The conditioner composition of any one of embodiments 1- 27, wherein the LNP dispersion comprises any one of the formulations in Table 17 or Table 18.
  • Embodiment 29 The conditioner composition of any one of embodiments 1- 28, wherein the LNP dispersion further comprises an oil, a preservative, or both the oil and the preservative.
  • Embodiment 30 The conditioner composition of any one of embodiments 1- 27, wherein the LNP dispersion comprises any one of the formulations in Table 19, Table 20, or Table 21.
  • Embodiment 31 The conditioner composition of any one of embodiments 1- 30, wherein the conditioner composition comprises a peptide or polypeptide.
  • Embodiment 32 The conditioner composition of any one of embodiments 1- 27, wherein the LNP dispersion comprises any one of the formulations in Table 17 or Table 18.
  • Embodiment 33 The conditioner composition of any one of embodiments 1- 31, wherein the conditioner composition further comprises a solvent in addition to water.
  • Embodiment 33 The conditioner composition of any one of embodiments 1- 32, wherein the conditioner composition further comprises a solvent in addition to water.
  • Embodiment 34 The conditioner composition of embodiment 33, wherein the solvent is selected from: alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate.
  • Embodiment 35 The conditioner composition of any one of embodiments 32- 34, wherein the solvent other than water is present at 0.1 to 20% by total weight of the conditioner composition.
  • Embodiment 36 The conditioner composition of any one of embodiments 32- 34, wherein the solvent other than water is present at 1 to 10% by total weight of the conditioner composition.
  • Embodiment 37 The conditioner composition of any one of embodiments 32- 34, wherein the conditioner composition comprises any one of the formulations of Table 22 or Table 23.
  • Embodiment 38 The conditioner composition of any one of embodiments 32- 34, wherein the conditioner composition comprises any one of the formulations of Table 24 or Table 25.
  • Embodiment 39 The conditioner composition of any one of embodiments 1- 38, wherein the conditioner composition further comprises an emulsifier.
  • Embodiment 40 Embodiment 40.
  • the conditioner composition of embodiment 39 wherein the emulsifier is selected from: natural oils, fatty alcohols, silicones (e.g., dimethicone), natural butters, or synthetic esters.
  • Embodiment 41 The conditioner composition of embodiment 40, wherein the emulsifier is selected from: lecithin, hydrogenated lecithin, phosphatidylcholine, [C12-16 alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl/capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3
  • Embodiment 42 The conditioner composition of any one of embodiments 39- 41, wherein the emulsifier is present at 1 to 10% by total weight of the conditioner composition.
  • Embodiment 43 The conditioner composition of any one of embodiments 32- 34, wherein the conditioner composition comprises any one of the formulations of Table 26 or Table 27.
  • Embodiment 44 The conditioner composition of any one of embodiments 32- 34, wherein the conditioner composition comprises any one of the formulations of Table 28 or Table 29.
  • Embodiment 45 The conditioner composition of any one of embodiments 1- 44, wherein the conditioner composition further comprises a conditioning agent.
  • Embodiment 46 Embodiment 46.
  • Embodiment 47 The conditioner composition of any one of embodiments 1- 46, wherein the conditioner composition further comprises a humectant.
  • Embodiment 48 The conditioner composition of embodiment 47, wherein the conditioner composition comprises any one of the formulations of Table 34, Table 35, Table 36, or Table 37.
  • Embodiment 49 The conditioner composition of any one of embodiments 1- 48, wherein the conditioner composition further comprises an emollient.
  • Embodiment 50 The conditioner composition of embodiment 49, wherein the conditioner composition comprises any one of the formulations of Table 38, Table 39, Table 40, or Table 41.
  • Embodiment 51 The conditioner composition of any one of embodiments 1- 50, wherein the conditioner composition further comprises a pollution protectant.
  • Embodiment 52 The conditioner composition of embodiment 51, wherein the conditioner composition comprises any one of the formulations of Table 42, Table 43, Table 44, or Table 45.
  • Embodiment 53 The conditioner composition of any one of embodiments 1- 52, wherein the conditioner composition further comprises a preservative.
  • Embodiment 54 The conditioner composition of embodiment 53, wherein the conditioner composition comprises any one of the formulations of Table 46, Table 47, Table 48, or Table 49.
  • WSGR Docket No.: 63230-729.601 [0287] Embodiment 55.
  • Embodiment 56 The conditioner composition of any one of embodiments 1- 54, wherein the conditioner composition further comprises a pH modifier.
  • Embodiment 56 The conditioner composition of embodiment 55, wherein the conditioner composition comprises any one of the formulations of Table 50, Table 51, Table 52, or Table 53.
  • Embodiment 57 A method of protecting hair of an individual, the method comprising: applying the conditioner composition of any one of embodiments 1-56 to the hair of the individual.
  • Embodiment 58. The method of embodiment 58, wherein the method further comprises: lathering the hair with the conditioner composition; and rinsing the hair of the individual.
  • Embodiment 59 Embodiment 59.
  • a method of improving the protective properties of a conditioner composition comprising: adding the LNP dispersion to a conditioner composition to generate the conditioner composition of any one of embodiments 1-56.
  • Embodiment 60 The method of embodiment 65, wherein the protective property comprises protection against UV damage.
  • Embodiment 61 A cleanser, comprising a detoxifying agent and a hair conditioner.
  • Embodiment 62 The cleanser of embodiment 61, wherein the detoxifying agent comprises an absorbent.
  • Embodiment 63 The cleanser of embodiment 61, wherein the absorbent comprises a charcoal.
  • Embodiment 64 Embodiment 64.
  • Embodiment 65 The cleanser of any one of embodiments 61-63, wherein the detoxifying agent is present in the cleanser at about 0.01% (w/w) to about 1.0% (w/w).
  • Embodiment 65 The cleanser of any one of embodiments 61-64, wherein the hair conditioner is present in the cleanser at about 0.01% (w/w) to about 70% (w/w) of the cleanser.
  • Embodiment 66 Embodiment 66.
  • the cleanser of any one embodiments 61-65 wherein the hair conditioner comprises panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof.
  • the hair conditioner comprises panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof.
  • WSGR Docket No.: 63230-729.601 [0299]
  • Embodiment 67 The cleanser of any one of embodiments 61-66, comprising a skin conditioner.
  • Embodiment 69 The cleanser of embodiment 67 or embodiment 68, wherein the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisate leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof.
  • Embodiment 70 Embodiment 70.
  • Embodiment 71 The cleanser of embodiment 70, wherein the total concentration (%w/w) of the cleansing agent is about 5% to about 85%.
  • Embodiment 72 The cleanser of embodiment 70 or embodiment 71, wherein the one cleansing agent is a surfactant.
  • Embodiment 73 The cleanser of embodiment 72, wherein the surfactant comprises an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof.
  • Embodiment 74 Embodiment 74.
  • Embodiment 75 The cleanser of embodiment 74, wherein the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylenesulfonate, sodium C74-76 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylenesulfonate, TEA-dodecylbenzenesulfonate, ethyl PEG-75 cocamine sulfate, dio
  • Embodiment 79 The cleanser of embodiment 78, wherein the excipient is a cosmetically acceptable excipient.
  • Embodiment 80 The cleanser of embodiment 78 or embodiment 79, wherein the excipient is a dermatologically acceptable excipient.
  • Embodiment 81 The cleanser of any one of embodiments 78-80, wherein the excipient is present in the cleanser at about 0.1% (%w/w) to about 90% (%w/w) of the cleanser.
  • Embodiment 82 Embodiment 82.
  • Embodiment 85 The cleanser of any one of embodiments 78-81, wherein the excipient comprises a humectant.
  • Embodiment 83 The cleanser of embodiment 82, wherein the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof.
  • Embodiment 84 The cleanser of embodiment 82 or embodiment 83, wherein the humectant is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser.
  • Embodiment 85 Embodiment 85.
  • Embodiment 86 The cleanser of embodiment 85, wherein the chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof.
  • Embodiment 87 The cleanser of embodiment 85 or embodiment 86, wherein the chelating agent is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser.
  • Embodiment 88 Embodiment 88.
  • Embodiment 89 The cleanser of embodiment 88, wherein the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof.
  • WSGR Docket No.: 63230-729.601 [0322]
  • Embodiment 90 The cleanser of embodiment 88 or embodiment 89, wherein the buffer is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser.
  • Embodiment 91 Embodiment 91.
  • Embodiment 95 The cleanser of embodiment 94, wherein the concentration (%w/w) of the solvent is about 50% to about 99%.
  • Embodiment 96 The cleanser of embodiment 1, wherein pH of the cleanser is about 2 to about 6.
  • Embodiment 97 The cleanser of any one of embodiments 61-96, wherein the cleanser is hair cleanser.
  • Embodiment 98 A method for cleansing hair or using the cleanser of embodiment 61.
  • Embodiment 99 A cleanser, comprising: a detoxifying agent.
  • Embodiment 100 Embodiment 100.
  • Embodiment 101 The cleanser of embodiment 100, wherein the absorbent comprises charcoal.
  • Embodiment 102 The cleanser of any one of embodiments 99-101, wherein the detoxifying agent is present in the cleanser at about 0.01% (w/w) to about 1.0% (w/w).
  • Embodiment 103 The cleanser of any one of embodiments 99-102, further comprising a hair conditioner.
  • Embodiment 104 Embodiment 104.
  • Embodiment 105 The cleanser of embodiment 103 or embodiment 104, wherein the hair conditioner is present in the cleanser at about 0.01% (%w/w) to about 70% (%w/w) of the cleaner.
  • Embodiment 106 Embodiment 106.
  • Embodiment 107 The cleanser of embodiment 106, wherein the skin conditioner is present in the cleanser at about 0.01% (%w/w) to about 5% (%w/w) of the cleaner.
  • Embodiment 108 Embodiment 108.
  • Embodiment 118 The cleanser of embodiment 117, wherein the excipient is a cosmetically acceptable excipient.
  • Embodiment 119 The cleanser of embodiment 117 or embodiment 118, wherein the excipient is a dermatologically acceptable excipient.
  • Embodiment 120 The cleanser of any one of embodiments 117-119, wherein the excipient is present in the cleanser at about 0.1% (%w/w) to about 90% (%w/w) of the cleanser.
  • Embodiment 121 The cleanser of any one of embodiments 117-120, wherein the excipient comprises a humectant.
  • Embodiment 122 Embodiment 122.
  • Embodiment 123 The cleanser of embodiment 121 or embodiment 122, wherein the humectant is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser.
  • Embodiment 124 The cleanser of any one of embodiments 117-123, wherein the excipient comprises a chelating agent.
  • Embodiment 125 Embodiment 125.
  • Embodiment 128 The cleanser of embodiment 127, wherein the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof.
  • Embodiment 129 The cleanser of embodiment 127 or embodiment 128, wherein the buffer is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser.
  • Embodiment 130 The cleanser of any one of embodiments 117-129, wherein the excipient comprises a preservative.
  • Embodiment 131 The cleanser of embodiment 130, wherein the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof.
  • Embodiment 132 The cleanser of embodiment 130 or embodiment 131, wherein the preservative is present in the cleanser at about 0.01% (%w/w) to about 0.1% (%w/w) of the cleanser.
  • Embodiment 133 The cleanser of any one of embodiments 99-132, comprising a solvent.
  • Embodiment 134 Embodiment 134.

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Abstract

L'invention concerne des compositions de conditionnement des cheveux comprenant : une nanoparticule lipidique contenant (par exemple, encapsulant) un céramide et de la vitamine E, qui sont utiles pour protéger les cheveux contre un endommagement par les ultraviolets, un endommagement par contrainte mécanique et/ou un endommagement dû à l'environnement. L'invention concerne également des compositions de lavage pour les cheveux.
PCT/US2024/061181 2023-12-19 2024-12-19 Compositions de conditionnement, compositions de lavage et leurs procédés d'utilisation Pending WO2025137392A1 (fr)

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US202363612223P 2023-12-19 2023-12-19
US63/612,214 2023-12-19
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150079137A1 (en) * 2012-03-22 2015-03-19 Lipotec, S.A. Exopolysaccharide for the treatment and/or care of the skin, mucous membranes and/or nails
US20160263014A1 (en) * 2013-10-30 2016-09-15 Lipotec, S.A.U. Exopolysaccharide for the treatment and/or care of the skin, culture media and compositions
US20180369115A1 (en) * 2015-12-10 2018-12-27 Lubrizol Advanced Materials, Inc. Compounds useful in the treatment and/or care of the skin, hair, nails, and/or mucous membranes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150079137A1 (en) * 2012-03-22 2015-03-19 Lipotec, S.A. Exopolysaccharide for the treatment and/or care of the skin, mucous membranes and/or nails
US20160263014A1 (en) * 2013-10-30 2016-09-15 Lipotec, S.A.U. Exopolysaccharide for the treatment and/or care of the skin, culture media and compositions
US20180369115A1 (en) * 2015-12-10 2018-12-27 Lubrizol Advanced Materials, Inc. Compounds useful in the treatment and/or care of the skin, hair, nails, and/or mucous membranes

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