[go: up one dir, main page]

WO2025133372A1 - Utilisation d'un composé précurseur de cystéine - Google Patents

Utilisation d'un composé précurseur de cystéine Download PDF

Info

Publication number
WO2025133372A1
WO2025133372A1 PCT/EP2024/088281 EP2024088281W WO2025133372A1 WO 2025133372 A1 WO2025133372 A1 WO 2025133372A1 EP 2024088281 W EP2024088281 W EP 2024088281W WO 2025133372 A1 WO2025133372 A1 WO 2025133372A1
Authority
WO
WIPO (PCT)
Prior art keywords
increasing
melanocytes
hair
carboxymethyl
melanin production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/088281
Other languages
English (en)
Inventor
Ranjit Kaur Bhogal
Geoffrey Robert Victor HAWKINS
Stephen John Singleton
Ian Karl Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever Global IP Ltd
Unilever IP Holdings BV
Conopco Inc
Original Assignee
Unilever Global IP Ltd
Unilever IP Holdings BV
Conopco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Global IP Ltd, Unilever IP Holdings BV, Conopco Inc filed Critical Unilever Global IP Ltd
Publication of WO2025133372A1 publication Critical patent/WO2025133372A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

Definitions

  • the present invention relates to a new use of a carboxymethyl cysteine compound or a hair care composition comprising a carboxymethyl cysteine compound.
  • hair greying and canities is a common sign of aging. Hair also loses its elasticity, becomes thinner and more fragile. Further, hair follicle diameter and hair number can also decrease giving a sparse appearance to the scalp.
  • compositions that provide an effective reduction in age-related functional changes in hair pigmentation. It is also required to provide a composition which is also able to reduce or prevent other detrimental changes in hair associated with aging.
  • a cysteine precursor compound a carboxymethyl cysteine compound is effective at reducing age-related functional changes in hair pigmentation, while also providing a beneficial improvement in further hair characteristics associated with aging.
  • carboxymethyl cysteine compounds have been surprisingly shown to increase the cellular metabolic activity and melanin production of melanocytes.
  • the carboxymethyl cysteine compounds can increase the melanin production of melanocytes above natural pigmentation levels.
  • the present invention is directed to use of a carboxymethyl cysteine compound or a hair care composition comprising a carboxymethyl cysteine compound for increasing melanin production in melanocytes, for reducing the occurrence of grey or white hairs of an individual, for reducing age-related functional changes in hair pigmentation, for increasing melanin production in hair e.g. grey hair, for increasing cell proliferation, for increasing melanocyte proliferation, for increasing melanosome transfer, for increasing the level and/or activity of tyrosinase, for increasing gene and/or protein expression in pigmentation pathways associated with hair, for reducing oxidative stress of the scalp and/or a hair follicle, for increasing cellular metabolic activity.
  • the invention is directed to a carboxymethyl cysteine compound or a hair care composition comprising a carboxymethyl cysteine compound for increasing melanin production in melanocytes, preferably for increasing melanin production in a hair follicle.
  • a carboxymethyl cysteine compound or a hair care composition comprising a carboxymethyl cysteine compound for increasing melanin production in melanocytes, preferably for increasing melanin production in a hair follicle.
  • the invention is directed to a carboxymethyl cysteine compound or a hair care composition comprising a carboxymethyl cysteine compound for increasing cellular metabolic activity of melanocytes, preferably for increasing the cellular metabolic activity of melanocytes in a hair follicle.
  • the present invention is directed to a carboxymethyl cysteine compound or a hair care composition
  • a carboxymethyl cysteine compound for use in the treatment for increasing melanin production in melanocytes, for reducing the occurrence of grey or white hairs of an individual, for reducing age-related functional changes in hair pigmentation, for increasing melanin production in grey hair, for increasing cell proliferation, for increasing melanocyte proliferation, for increasing melanosome transfer, for increasing the level and/or activity of tyrosinase, for increasing gene and/or protein expression in pigmentation pathways associated with hair, for reducing oxidative stress of the scalp and/or a hair follicle, and/or for increasing cellular metabolic activity.
  • the present invention is directed to a carboxymethyl cysteine compound or a hair care composition comprising a carboxymethyl cysteine compound for use in a treatment for increasing melanin production in melanocytes, preferably for increasing melanin production in a hair follicle.
  • a carboxymethyl cysteine compound or a hair care composition comprising a carboxymethyl cysteine compound for use in a treatment for increasing melanin production in melanocytes, preferably for increasing melanin production in a hair follicle.
  • the present invention is directed to a carboxymethyl cysteine compound or a hair care composition comprising a carboxymethyl cysteine compound for use in the treatment for increasing the cellular metabolic activity of cells in a hair follicle, preferably for increasing cellular metabolic activity of melanocytes, preferably for increasing the cellular metabolic activity of melanocytes in a hair follicle.
  • a carboxymethyl cysteine compound or a hair care composition comprising a carboxymethyl cysteine compound for use in the treatment for increasing the cellular metabolic activity of cells in a hair follicle, preferably for increasing cellular metabolic activity of melanocytes, preferably for increasing the cellular metabolic activity of melanocytes in a hair follicle.
  • for increasing the cellular metabolic activity level of melanocytes above the level in unstressed melanocytes for increasing the cellular metabolic activity level of melanocytes above the level in unstressed melanocytes.
  • the present invention is directed to use of a hair care composition for increasing melanin production in melanocytes, for reducing the occurrence of grey or white hairs of an individual, for reducing age-related functional changes in hair pigmentation, for increasing melanin production in grey hair, for increasing cell proliferation, for increasing melanocyte proliferation, for increasing melanosome transfer, for increasing the level and/or activity of tyrosinase, for increasing gene and/or protein expression in pigmentation pathways associated with hair, for reducing oxidative stress of the scalp and/or a hair follicle and/or for increasing cellular metabolic activity.
  • the present invention is directed to use of a hair care composition for increasing melanin production in melanocytes, preferably for increasing melanin production in a hair follicle.
  • a hair care composition for increasing melanin production level of melanocytes above the level in unstressed melanocytes.
  • the present invention is directed to a hair care composition for use in the treatment for increasing cellular metabolic activity of melanocytes, preferably for increasing the cellular metabolic activity of melanocytes in a hair follicle.
  • the present invention is directed to a method for increasing melanin production in melanocytes, for reducing the occurrence of grey or white hairs of an individual, for reducing age- related functional changes in hair pigmentation, for increasing melanin production in grey hair, for increasing cell proliferation, for increasing melanocyte proliferation, for increasing melanosome transfer, for increasing the level and/or activity of tyrosinase, for increasing gene and/or protein expression in pigmentation pathways associated with hair, for reducing oxidative stress of the scalp and/or a hair follicle, comprising application of a haircare composition comprising a cysteine precursor compound to the hair or scalp.
  • the method is for increasing melanin production in melanocytes, preferably for increasing melanin production in a hair follicle.
  • the method is for increasing the melanin production level of melanocytes above the level in unstressed melanocytes.
  • the method is for increasing cellular metabolic activity of melanocytes, preferably for increasing the cellular metabolic activity of melanocytes in a hair follicle.
  • the method comprising application to the hair or scalp of a cosmetic composition comprising a carboxymethyl cysteine compound.
  • the present invention is directed to use of a carboxymethyl cysteine compound in a method for increasing melanin production in melanocytes, for reducing the occurrence of grey or white hairs of an individual, for reducing age-related functional changes in hair pigmentation, for increasing melanin production in grey hair, for increasing cell proliferation, for increasing melanocyte proliferation, for increasing melanosome transfer, for increasing the level and/or activity of tyrosinase, for increasing gene and/or protein expression in pigmentation pathways associated with hair, for reducing oxidative stress of the scalp and/or a hair follicle on the scalp, the method comprising application to the hair or scalp of a cosmetic composition comprising the carboxymethyl cysteine compound.
  • the present invention is directed to use of carboxymethyl cysteine compound in a method for increasing melanin production in melanocytes, preferably for increasing melanin production in a hair follicle.
  • a method for increasing melanin production in melanocytes preferably for increasing melanin production in a hair follicle.
  • the method is for increasing cellular metabolic activity of melanocytes, preferably for increasing the cellular metabolic activity of melanocytes in a hair follicle.
  • the present invention is directed to use of a carboxymethyl cysteine compound in the manufacture of medicants for increasing melanin production, reducing the occurrence of grey or white hairs of an individual, for reducing age-related functional changes in hair pigmentation, for increasing melanin production in grey hair, for increasing cell proliferation, for increasing melanocyte proliferation, for increasing melanosome transfer, for increasing the level and/or activity of tyrosinase, for increasing gene and/or protein expression in pigmentation pathways associated with hair, for reducing oxidative stress of the scalp and/or a hair follicle and/or for increasing cellular metabolic activity.
  • the present invention is directed to use of a carboxymethyl cysteine compound in the manufacture of medicants for increasing melanin production in melanocytes, preferably for increasing melanin production in a hair follicle.
  • a carboxymethyl cysteine compound in the manufacture of medicants increasing cellular metabolic activity of melanocytes, preferably for increasing the cellular metabolic activity of melanocytes in a hair follicle.
  • the carboxymethyl cysteine compound refers to compounds selected from carboxymethyl cysteine, salt of carboxymethyl cysteine, ester of carboxymethyl cysteine, amide of carboxymethyl cysteine or a mixture thereof.
  • the carboxymethyl cysteine compound comprises carboxymethyl cysteine, ester of carboxymethyl cysteine, and/or salt of carboxymethyl cysteine.
  • the carboxymethyl cysteine compound comprises carboxymethyl cysteine, and/or salt of carboxymethyl cysteine.
  • carboxymethyl cysteine compound comprises salt of carboxymethyl cysteine.
  • the carboxymethyl cysteine compound comprises lysine carboxymethyl cysteinate and most preferably, the carboxymethyl cysteine compound is lysine carboxymethyl cysteinate.
  • lower alkyl alcohols include C1 to C6 monohydric alcohols such as ethanol and isopropanol.
  • polyhydric alcohols include propylene glycol, hexylene glycol, glycerin, and propanediol. Mixtures of any of the above-described organic solvents may also be used.
  • Menadione induces oxidative stress in melanocytes by generating reactive oxygen species (ROS).
  • ROS reactive oxygen species
  • the antioxidant effect of the test materials on melanocyte cells stressed with menadione was assessed by comparing the level of ROS of treated and untreated stressed cells. LCC was able to reduce the level of ROS compared to the level of ROS in menadione stressed cells. This indicates that the inclusion of LCC in a formulation improves the antioxidant activity of the melanocytes.
  • the catalase activity of cells treated with LCC showed a statistically significant increase in catalase activity compared to untreated stressed cells.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne l'utilisation d'un composé de carboxyméthyl cystéine ou d'une composition de soins capillaires comprenant un composé de carboxyméthyl cystéine pour augmenter la production de mélanine et/ou pour augmenter l'activité métabolique cellulaire de mélanocytes.
PCT/EP2024/088281 2023-12-22 2024-12-21 Utilisation d'un composé précurseur de cystéine Pending WO2025133372A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP23220184 2023-12-22
EP23220184.8 2023-12-22

Publications (1)

Publication Number Publication Date
WO2025133372A1 true WO2025133372A1 (fr) 2025-06-26

Family

ID=89429990

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2024/088281 Pending WO2025133372A1 (fr) 2023-12-22 2024-12-21 Utilisation d'un composé précurseur de cystéine

Country Status (1)

Country Link
WO (1) WO2025133372A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000051556A1 (fr) * 1999-02-28 2000-09-08 The Procter & Gamble Company Compositions traitantes pour cheveux comprenant des composes d'acides amines
US20080014229A1 (en) * 2004-12-22 2008-01-17 L'oreal Administration of compounds that increase glutathione levels in the melanocytes for the treatment of canities
US20120114583A1 (en) * 2009-07-23 2012-05-10 Henkel Ag & Co. Kgaa Use of dihydroquercetin and at least one amino acid to positively influence the natural pigmentation process
US20180042961A1 (en) * 2016-07-15 2018-02-15 Kay Jay, Llc Composition and method for altering hair pigmentation
US20190167561A1 (en) * 2016-08-15 2019-06-06 Natura Cosmeticos Sa Methods and compositions for reducing the graying of hair
US20210378934A1 (en) * 2018-10-29 2021-12-09 Givaudan Sa Hair care active agent
WO2023126169A1 (fr) * 2021-12-31 2023-07-06 Unilever Ip Holdings B.V. Utilisation d'un composé de carboxyméthylcystéine

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000051556A1 (fr) * 1999-02-28 2000-09-08 The Procter & Gamble Company Compositions traitantes pour cheveux comprenant des composes d'acides amines
US20080014229A1 (en) * 2004-12-22 2008-01-17 L'oreal Administration of compounds that increase glutathione levels in the melanocytes for the treatment of canities
US20120114583A1 (en) * 2009-07-23 2012-05-10 Henkel Ag & Co. Kgaa Use of dihydroquercetin and at least one amino acid to positively influence the natural pigmentation process
US20180042961A1 (en) * 2016-07-15 2018-02-15 Kay Jay, Llc Composition and method for altering hair pigmentation
US20190167561A1 (en) * 2016-08-15 2019-06-06 Natura Cosmeticos Sa Methods and compositions for reducing the graying of hair
US20210378934A1 (en) * 2018-10-29 2021-12-09 Givaudan Sa Hair care active agent
WO2023126169A1 (fr) * 2021-12-31 2023-07-06 Unilever Ip Holdings B.V. Utilisation d'un composé de carboxyméthylcystéine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KRISTINA RIEGEL: "L-Cystine-Containing Hair-Growth Formulation Supports Protection, Viability, and Proliferation of Keratinocytes", vol. Volume 13, 1 August 2020 (2020-08-01), United Kingdom, pages 499 - 510, XP093166877, ISSN: 1178-7015, Retrieved from the Internet <URL:https://www.dovepress.com/getfile.php?fileID=60235> DOI: 10.2147/CCID.S254720 *

Similar Documents

Publication Publication Date Title
EP2116224B1 (fr) Composition cosmétique
WO2020204191A1 (fr) Produit cosmétique contenant une substance de conversion de longueur d&#39;onde ultraviolette et agent médicinal
US6497892B2 (en) Cosmetic and skin protective compositions
EP2456418A2 (fr) Utilisation de dihydroquercétine et d&#39;au moins un acide aminé pour influencer positivement le processus de pigmentation naturel
WO2018113636A1 (fr) Additif topique d&#39;éclaircissement de la peau et composition comprenant des acides aminés et des acides gras activant les ppar
TWI359662B (fr)
JP2024134554A (ja) 毛髪ケア活性剤
WO2018113637A1 (fr) Compositions de soins personnels avec un précurseur de glutathion, comprenant du nicotinamide et des acides aminés
CN113425651A (zh) 一种具有美白功效的化妆品组合物及其应用
EP3558246A1 (fr) Compositions de soins personnels avec un précurseur de glutathion comprenant des résorcinols substitués en position 4 et des acides aminés
CN108113920A (zh) 一种缓释美白复合保湿面霜基质及其制备方法和应用
CN117064817A (zh) 一种用于敏感肌的高效美白组合物及其应用
US10537507B2 (en) All-in-one skin brightening formulations specifically for pregnant subjects
WO2025133372A1 (fr) Utilisation d&#39;un composé précurseur de cystéine
EP1147765B1 (fr) Nouvel actif, composition le renfermant et utilisation en cosmétique, dermocosmétique, dermopharmacie ou pharmacie ou sur des supports tisses ou non tisses
KR100472919B1 (ko) 수용성 미백 조성물 및 그를 함유하는 피부 미백용 화장료조성물
WO2025133279A1 (fr) Compositions de soins capillaires
CN117898979A (zh) 具有美白作用的皛白肽及其制备方法和应用
JP7638084B2 (ja) 常在菌抗菌剤
JPH08165227A (ja) 染毛剤組成物
KR20020027919A (ko) 스핑고리피드 또는 그 대사산물을 함유하는 미백 화장료조성물
KR102814373B1 (ko) Eckmaxol을 유효성분으로 포함하는 항산화 또는 미백용 화장료 조성물
US20250195401A1 (en) Cosmetic composition of liposomes containing an extract of haematococcus pluvialis, tetrahexyldecyl ascorbate and ectoin
WO2019096546A1 (fr) Peptides pour augmenter la mélanine dans les mélanocytes
WO2025133109A1 (fr) Compositions de soins capillaires

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 24837054

Country of ref document: EP

Kind code of ref document: A1