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WO2025125673A1 - Nouvelle utilisation - Google Patents

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Publication number
WO2025125673A1
WO2025125673A1 PCT/EP2024/086498 EP2024086498W WO2025125673A1 WO 2025125673 A1 WO2025125673 A1 WO 2025125673A1 EP 2024086498 W EP2024086498 W EP 2024086498W WO 2025125673 A1 WO2025125673 A1 WO 2025125673A1
Authority
WO
WIPO (PCT)
Prior art keywords
iodoethanol
animal
day
premix
vitamins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/086498
Other languages
English (en)
Inventor
Maik Kindermann
René Tobias STEMMLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of WO2025125673A1 publication Critical patent/WO2025125673A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/30—Oligoelements
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/20—Reduction of greenhouse gas [GHG] emissions in agriculture, e.g. CO2
    • Y02P60/22—Methane [CH4], e.g. from rice paddies

Definitions

  • the present invention relates to the field of reduction of methane emission in ruminants. Particularly, it relates to the administration of 2-iodoethanol in an amount of at least 0.5 g 2- iodoethanol/ animal/ day to a ruminant for reducing the production of methane emanating from the digestive activities of said ruminant.
  • the present invention further relates to animal premix consisting essentially of (a) 2-iodoeth- anol and optionally one or more of (b-1) fat soluble vitamin(s), (b-2) water soluble vitamin(s), (b-3) trace mineral(s) and (b-4) macro mineral(s) and (c) a carrier as well as the use of said pre-mix for reducing the production of methane emanating from the digestive activities of ruminants.
  • the temperature of the air surrounding the earth is increasing, a process referred to as global warming.
  • One of the main focuses to reduce this warming effect is to reduce the amount of greenhouse gases emitted into the atmosphere.
  • Greenhouse gases are emitted from several different sources, both natural and artificial; however, the two sources with the most emphasis are the agricultural and fossil fuel industries.
  • ruminants and in particular cattle are the major contributors to the biogenic methane formation, and it has been estimated that the prevention of methane formation from ruminants would almost stabilize atmospheric methane concentrations.
  • 2-iodoethanol (CAS No: 624-76-0) may be isolated from red alga Asparagopsis taxiformis.
  • the present invention provides the use of 2-iodoethanol in an amount of at least 0.5 g 2-iodoethanol/ animal/ day for reducing the formation of methane emanating from the digestive activities of ruminants.
  • the invention further provides a method for reducing the production of methane emanating from the digestive activities of ruminants, said method comprising orally administering to the animal an 2-iodoethanol in an amount of at least 0.5 g 2-iodoetha- nol/ animal/ day.
  • the present invention relates to a (ruminant) pre-mix comprising 2- iodoethanol and optionally one or more of (b-1) fat soluble vitamin(s), (b-2) water soluble vitamins), (b-3) trace mineral(s) and (b-4) macro mineral(s) and (c) a carrier.
  • the methane reduction by the administration of 2-iodoethanol is preferably at least 10 %, more preferably at least 20 %, most preferably at least 30 % when compared to control, i.e. to ruminants not supplemented with 2-iodoethanol.
  • the present invention also relates to the use of 2-iodoethanol in amounts of at least 0.5g/ animal/ day wherein the methane production in ruminants is reduced by at least 10 % compared to control.
  • the effective amount of 2-iodoethanol to be administered to the ruminants is selected in the range from 0.5 to 200 g 2-iodoethanol/ animal/ day, more preferably in the range from 1 to 150 g 2-iodoethanol/ animal/ day, most preferably in the range from 5 to 100 g 2-iodoethanol/ animal/ day, such as in the range from 10 to 100 g 2-iodoethanol/ animal/ day, 15 to 100 g 2-iodoethanol/ animal/ day or 20 to 100 g 2-iodoethanol/ animal/ day.
  • 2-iodoethanol is preferably administered either as pure (distinct) chemical compound (i.e. having a purity of >95% (HPLC)) or via an animal premix to the ruminant, both of which are then dispersed throughout the animal feed (diet) by any of a number of ordinary mixing techniques.
  • premixes are well known to a person skilled in the art.
  • such premixes comprise the active ingredient, i.e. 2-iodoethanol, a carrier, and optionally further nutritional ingredients selected from the group consisting of such as vitamins, trace minerals and macro minerals.
  • a premix designates a preferably uniform mixture of one or more micro-ingredients with diluents and/or carrier. Premixes are used to facilitate uniform dispersion of micro-ingredients in a larger mix.
  • Particular advantageous premixes according to the present invention consist essentially of (a) 2-iodoethanol and optionally of one or more of (b-1) fat soluble vitamin(s), (b-2) water soluble vitamin(s), (b-3) trace mineral(s) and (b-4) macro mineral(s) and (c) a carrier
  • Usual carriers employed in the art are soy grits, clays, (corn) sugars, silica, starch and similar products.
  • Said pre-mix may be prepared by methods known per se in the art.
  • Methane emission by ruminants can easily be measured in individual animals in metabolic chambers by methods known in the art (Grainger et al., 2007 J. Dairy Science; 90: 2755- 2766). Moreover, it can also be assessed at barn level by an emerging technology using laser beam (McGinn et al., 2009, Journal of Environmental Quality; 38: 1796-1802) or Sulfur hexafluoride or just SF6 or GreenFeed system. Alternatively, methane produced by a dairy ruminant can also be assessed by measurement of fatty acid profiles in milk according to WO 2009/156453.
  • diallyl disulfide, garlic oil, allyl isothiocyanate deoxycholic acid, chenodeoxycholic acid and derivatives thereof are independently administered in dosage ranges of for example 0.01-500 mg active substance per kg feed (ppm).
  • ppm active substance per kg feed
  • Propanediol mononitrate (3-nitrooxypropan-1-ol) preferably is administered to the ruminants in the range from 0.025 to 5 g 3-nitrooxypropanol I animal/ day, more preferably in the range from 0.05 to 4 g 3-nitrooxypropanol I animal/ day, most preferably in the range from 0.125 to 3 g 3-nitrooxypropanol I animal/ day. Further suitable effective amounts are selected in the range from 0.25 to 3 g 3-nitrooxypropanol I animal/ day or from 0.5 to 3 g 3-nitrooxypropanol/ animal/ day.
  • domestic cattle, sheep and goat are the more preferred species.
  • most preferred species are domestic cattle.
  • the term includes all races of domestic cattle, and all production kinds of cattle, in particular dairy cows and beef cattle. It is well understood, that the term dairy cows and beef cattle encompasses animals in all ages and physiological stage of life and production systems such as confined, semi-confined and grazing.
  • dairy cows and beef cattle encompasses animals in all ages and physiological stage of life and production systems such as confined, semi-confined and grazing.
  • the present invention is further described by the following examples which should not be construed as limiting the scope of the invention.
  • HFT HFT
  • Feed is gadded into a syringe with a composition of rumen liquor and an appropriate mixture of buffers.
  • the solution is incubated at 39°C. After 8 hours the quantity (and composition) of gas phase produced is measured and put into a formula for conversion.
  • the feed stuff i.e. TMR (44 % concentrate, 6 % hay, 37 % maize silage and 13 % grass silage) is sieved to 1 mm and weighed exactly into 64 syringes. 4 of these syringes are the substrate controls, which display the gas production without the effect of the tested compounds. The remaining syringes contain the test substances, by groups of 4 syringes.
  • the components are mixed in a Woulff bottle in following order:
  • the completed solution is warmed up to 39 °C followed by the addition of 1.83 ml sodium salt solution and the addition of reduction solution at 36 °C.
  • the rumen liquor is added, when the indicator turns colourless.
  • the diluted rumen fluid (24 ml) is added to the glass syringe.
  • the syringes are then incubated for 8 hours at 39 °C under gentle agitation. After 8 hours, the volume of gas produced is measured, and the percentage of methane in the gas phase is determined by gas chromatography.
  • the food fermented was artificial TMR (44 % concentrate, 6 % hay, 37 % maize silage and 13 % grass silage). 2-lodoethanol was used at three different concentrations 20, 50 and 100 pM.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)

Abstract

La présente invention concerne le domaine de la réduction de l'émission de méthane chez les ruminants. En particulier, elle concerne l'administration de 2-iodoéthanol en une quantité d'au moins 0,5 g de 2-iodoéthanol/animal/jour à un ruminant pour réduire la production de méthane émanant des activités digestives dudit ruminant.
PCT/EP2024/086498 2023-12-14 2024-12-16 Nouvelle utilisation Pending WO2025125673A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP23216542 2023-12-14
EP23216542.3 2023-12-14

Publications (1)

Publication Number Publication Date
WO2025125673A1 true WO2025125673A1 (fr) 2025-06-19

Family

ID=89222518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2024/086498 Pending WO2025125673A1 (fr) 2023-12-14 2024-12-16 Nouvelle utilisation

Country Status (1)

Country Link
WO (1) WO2025125673A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009156453A1 (fr) 2008-06-25 2009-12-30 Valorisation Par Extrusion Procédé d'évaluation de la quantité de méthane produite par un ruminant laitier et procédé pour diminuer et contrôler cette quantité
US9980995B2 (en) * 2014-01-21 2018-05-29 Commonwealth Scientific And Industrial Research Organisation Method for reducing total gas production and/or methane production in a ruminant animal
WO2021258146A1 (fr) * 2020-06-24 2021-12-30 University Of The Sunshine Coast Composés bioactifs issus d'algues et procédé
WO2022232876A1 (fr) * 2021-05-04 2022-11-10 GrainCorp Limited Formulation d'aliment liquide pour ruminants et procédé de préparation de ladite formulation d'aliment liquide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009156453A1 (fr) 2008-06-25 2009-12-30 Valorisation Par Extrusion Procédé d'évaluation de la quantité de méthane produite par un ruminant laitier et procédé pour diminuer et contrôler cette quantité
US9980995B2 (en) * 2014-01-21 2018-05-29 Commonwealth Scientific And Industrial Research Organisation Method for reducing total gas production and/or methane production in a ruminant animal
WO2021258146A1 (fr) * 2020-06-24 2021-12-30 University Of The Sunshine Coast Composés bioactifs issus d'algues et procédé
WO2022232876A1 (fr) * 2021-05-04 2022-11-10 GrainCorp Limited Formulation d'aliment liquide pour ruminants et procédé de préparation de ladite formulation d'aliment liquide

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AILBHE MCGURRIN ET AL: "Anti-methanogenic potential of seaweeds and seaweed-derived compounds in ruminant feed: current perspectives, risks and future prospects", JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, BIOMED CENTRAL LTD, LONDON, UK, vol. 14, no. 1, 2 December 2023 (2023-12-02), pages 1 - 27, XP021328341, DOI: 10.1186/S40104-023-00946-W *
BURRESON B. JAY ET AL: "Volatile Halogen Compounds in the Alga Asparagopsis taxiformis (Rhodophyta)", J. AGRIC. FOOD CHEM., vol. 24, no. 4, 1 January 1976 (1976-01-01), pages 856 - 861, XP055892894, Retrieved from the Internet <URL:https://pubs.acs.org/doi/pdf/10.1021/jf60206a040> *
GRAINGER ET AL., J. DAIRY SCIENCE, vol. 90, no. 624-76-0, 2007, pages 2755 - 2766
JANICE I MCCAULEY ET AL: "Management of enteric methanogenesis in ruminants by algal- derived feed additives", vol. 6, no. 3, 30 November 2019 (2019-11-30), pages 188 - 205, XP009547000, ISSN: 2198-6592, Retrieved from the Internet <URL:https://link.springer.com/article/10.1007/s40726-020-00151-7/fulltext.html> [retrieved on 20200707], DOI: 10.1007/S40726-020-00151-7 *
MCGINN ET AL., JOURNAL OF ENVIRONMENTAL QUALITY, vol. 38, 2009, pages 1796 - 1802
ROQUE BREANNA M. ET AL: "Red seaweed (Asparagopsis taxiformis) supplementation reduces enteric methane by over 80 percent in beef steers", PLOS ONE, vol. 16, no. 3, 17 March 2021 (2021-03-17), pages e0247820, XP093009731, DOI: 10.1371/journal.pone.0247820 *

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