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WO2025125590A2 - Tcr reconnaissant le ras à mutation g12v et leurs utilisations - Google Patents

Tcr reconnaissant le ras à mutation g12v et leurs utilisations Download PDF

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Publication number
WO2025125590A2
WO2025125590A2 PCT/EP2024/086261 EP2024086261W WO2025125590A2 WO 2025125590 A2 WO2025125590 A2 WO 2025125590A2 EP 2024086261 W EP2024086261 W EP 2024086261W WO 2025125590 A2 WO2025125590 A2 WO 2025125590A2
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WO
WIPO (PCT)
Prior art keywords
ras
peptide
tcr
mutated human
seq
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Pending
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PCT/EP2024/086261
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WO2025125590A3 (fr
Inventor
Reagan JARVIS
Luke PASE
Ryan Hill
Hugh Salter
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Genovie AB
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Genovie AB
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Priority claimed from EP23217230.4A external-priority patent/EP4570263A1/fr
Application filed by Genovie AB filed Critical Genovie AB
Publication of WO2025125590A2 publication Critical patent/WO2025125590A2/fr
Publication of WO2025125590A3 publication Critical patent/WO2025125590A3/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32T-cell receptors [TCR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4244Enzymes
    • A61K40/4253GTPases, e.g. Ras or Rho

Definitions

  • NY- , - . - - ESO + -*: . - - _. - . - . , . . . - TCR-1 - TCR-1 . - NY-ESO , . , - . , , , - - . ., . ’ -. , 2 . , . - + low . - - . -, - . , – -– - . . , , . ,. ,- . , : :

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne une sélection de cibles vérifiées pour des récepteurs de lymphocytes T (TCR) contre des peptides du sarcome du rat (RAS) mutés chez l'Homme ainsi que plusieurs nouveaux récepteurs de lymphocytes T (TCR) qui sont isolés et/ou exprimés dans une cellule modifiée, et qui reconnaissent spécifiquement un peptide du sarcome du rat (RAS) muté chez l'Homme par G12V, le peptide étant un peptide RAS Kirsten (KRAS) muté chez l'Homme, un peptide RAS Harvey (HRAS) muté chez l'Homme, ou un peptide RAS du neuroblastome (NRAS) humain, qui est constitué de VVVGAVGVGK (SEQ ID NO : 1) ou VVGAVGVGK (SEQ ID NO : 2) présentée dans un complexe HLA- A*11, et le TCR individuel comprenant une chaîne alpha de TCR et une chaîne bêta de TCR jumelées. L'invention concerne en outre des cellules modifiées et des vecteurs exprimant lesdits TCR et leurs utilisations médicales pour le traitement de patients atteints d'un cancer.
PCT/EP2024/086261 2023-12-15 2024-12-13 Tcr reconnaissant le ras à mutation g12v et leurs utilisations Pending WO2025125590A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP23217230.4A EP4570263A1 (fr) 2023-12-15 2023-12-15 Tcr reconnaissant ras muté g12v et leurs utilisations
EP23217230.4 2023-12-15
EP24198575.3 2024-09-05
EP24198575 2024-09-05

Publications (2)

Publication Number Publication Date
WO2025125590A2 true WO2025125590A2 (fr) 2025-06-19
WO2025125590A3 WO2025125590A3 (fr) 2025-07-17

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PCT/EP2024/086261 Pending WO2025125590A2 (fr) 2023-12-15 2024-12-13 Tcr reconnaissant le ras à mutation g12v et leurs utilisations

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017083316A1 (fr) 2015-11-09 2017-05-18 Globus Medical, Inc. Raccord en croix mis
WO2018083316A1 (fr) 2016-11-07 2018-05-11 Genovie Ab Système à composants multiples génétiquement modifiés pour l'identification et la caractérisation de récepteurs de lymphocytes t et d'antigènes de lymphocytes t
WO2018083317A1 (fr) 2016-11-07 2018-05-11 Genovie Ab Système à composants multiples génétiquement modifiés pour l'identification et la caractérisation de récepteurs de lymphocytes t, d'antigènes de lymphocytes t et de leur interaction fonctionnelle
WO2019016175A1 (fr) 2017-07-18 2019-01-24 Genovie Ab Système bibliothèque de vecteurs à deux composants pour l'assemblage rapide et diversification des cadres de lecture ouverts du récepteur de cellules t de pleine longueur

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111836638B (zh) * 2017-12-04 2024-10-29 美国卫生和人力服务部 针对突变的ras的hla i类限制性t细胞受体
WO2023064952A1 (fr) * 2021-10-15 2023-04-20 Windmil Therapeutics, Inc. Produits et procédés de détermination d'antigènes utiles dans l'immunothérapie anticancéreuse

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017083316A1 (fr) 2015-11-09 2017-05-18 Globus Medical, Inc. Raccord en croix mis
WO2018083316A1 (fr) 2016-11-07 2018-05-11 Genovie Ab Système à composants multiples génétiquement modifiés pour l'identification et la caractérisation de récepteurs de lymphocytes t et d'antigènes de lymphocytes t
WO2018083317A1 (fr) 2016-11-07 2018-05-11 Genovie Ab Système à composants multiples génétiquement modifiés pour l'identification et la caractérisation de récepteurs de lymphocytes t, d'antigènes de lymphocytes t et de leur interaction fonctionnelle
WO2019016175A1 (fr) 2017-07-18 2019-01-24 Genovie Ab Système bibliothèque de vecteurs à deux composants pour l'assemblage rapide et diversification des cadres de lecture ouverts du récepteur de cellules t de pleine longueur

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