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WO2025125362A1 - Matériau granulaire solide pour la préparation de produits de soins personnels - Google Patents

Matériau granulaire solide pour la préparation de produits de soins personnels Download PDF

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Publication number
WO2025125362A1
WO2025125362A1 PCT/EP2024/085746 EP2024085746W WO2025125362A1 WO 2025125362 A1 WO2025125362 A1 WO 2025125362A1 EP 2024085746 W EP2024085746 W EP 2024085746W WO 2025125362 A1 WO2025125362 A1 WO 2025125362A1
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WO
WIPO (PCT)
Prior art keywords
granular material
solid granular
peg
sodium
oil
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Pending
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PCT/EP2024/085746
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English (en)
Inventor
Ophelie ZEYONS
Holger Kreusch
Elie Bechet KOUAME AKANNY
Julie Grumelard
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BASF SE
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BASF SE
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Publication of WO2025125362A1 publication Critical patent/WO2025125362A1/fr
Pending legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/022—Powders; Compacted Powders
    • A61K8/0225—Granulated powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use

Definitions

  • the presently claimed invention relates to a solid granular material for use in the preparation of a personal care product. Further, the presently claimed invention relates to a method for preparing the solid granular material. The invention also relates to a kit-in-part comprising the solid granular material.
  • Personal care products such as sunscreens, shampoos, conditioners, and shower gels are ubiquitous parts of modern life. The requirements for these personal care products are constantly increasing regarding performance, sustainability, and cost. Long shelf-lives are also necessary for personal care products since they are often used for weeks to months; some of them being used mainly in particular seasons of the year such as sunscreen products or only in irregular intervals. At the same time, many preservatives used in personal care products to increase the shelf-life are suspected to cause allergic reactions at least with some consumers, so that there is a growing demand for personal care products with only low quantities of preservatives as well as for personal care products that are completely free of preservatives.
  • EP 0 006 741 A2 describes a self-emulsifying cosmetic base for use in the manufacture of cosmetic compositions in the form of oil-in-water emulsions.
  • the cosmetic base is provided in solid form having self-emulsifying properties.
  • the system in EP 0 006 741 A2 has the disadvantage that the base and the remaining components must be heated to obtain the personal care product. In the Examples of EP 0 006 741 A2, temperatures of at least 60 ° C are necessary for this step.
  • EP 0 754 448 Al describes a composition in form a homogenate powder which is selfemulsifying in water.
  • the powder is obtained from aqueous plant extracts.
  • the powder in EP 0 754 448 Al can have the disadvantage of dusting and the preparation method starting from aqueous plant extracts is not well suited for water-sensitive components.
  • the invention relates to a solid granular material for use in the preparation of a personal care product characterized in that the solid granular material comprises
  • the liquid additive (a) comprises an emollient, wherein the solid granular material comprises the emollient in an amount of from 1.0 to 30.0 wt.%, based on the total weight of the solid granular material, and wherein the emollient is selected from the group consisting of propylene glycol dicaprylate/dicaprate, cocoglycerides, caprylic/capric triglyceride, isopropyl myristate, octyldodecyl myristate, decyl oleate, propylheptyl caprylate, isorbide dicaprylate, cetearyl isononanoate, caprylyl caprylate/caprate, pentaerythrityl tetraethylhexanoate, coco- caprylate/caprate, oley
  • the solid granular material of the invention can be stored for extended periods of time. Transportation costs are greatly reduced compared to conventional personal care products since the weight of the water and other liquids present in conventional personal care products is saved.
  • the inventive granular material dissolves readily when combined with water by the end-user and allows for the rapid and simple preparation of ready-to-use personal care products, in particular emulsion-type personal care products and leave-on personal care products.
  • the invention relates to a method of preparing the solid granular material of the invention, wherein the method comprises the steps: a. Mixing a liquid additive (a), a carrier (b), a surfactant (c) and optionally an active agent (d) of the solid granular material to obtain a wet blend, wherein the liquid additive (a) comprises an emollient, wherein the emollient is selected from the group consisting of propylene glycol dicaprylate/dicaprate, cocoglycerides, caprylic/capric triglyceride, isopropyl myristate, octyldodecyl myristate, decyl oleate, propylheptyl caprylate, isorbide dicaprylate, cetearyl isononanoate, caprylyl caprylate/caprate, pentaerythrityl tetraethylhexanoate, coco-caprylate
  • the invention in a third aspect, relates to a kit-in-parts comprising at least a first inventive solid granular material and a second inventive solid granular material for the preparation of a personal care product.
  • the sunscreen composition may comprise one or more active agents, e.g., organic and inorganic UV filters, as well as other ingredients or additives, e.g., emulsifiers, emollients, viscosity regulators, stabilizers, preservatives, or fragrances.
  • active agents e.g., organic and inorganic UV filters
  • other ingredients or additives e.g., emulsifiers, emollients, viscosity regulators, stabilizers, preservatives, or fragrances.
  • the term “daily care composition” refers to any topical product which is intended to be used daily without or with a UV protection. In case UV protection is included, it absorbs and may further reflect and scatter certain parts of UV radiation and is used as an everyday care product for the human body, e.g. for face or body.
  • the daily care composition may comprise one or more active agents, e.g., organic and/or inorganic UV filters, as well as other ingredients or additives, e.g., emulsifiers, emollients, viscosity regulators, stabilizers, preservatives, or fragrances.
  • Suitable daily care composition are according to the present invention, e.g. leave-on face and body care products.
  • Suitable skin care preparations are e.g., moisturizing, anti-ageing, refining, and lifting preparations.
  • the cited leave-on compositions can be in the form of creams, ointments, pastes, foams, gels, lotions, powders, make-ups, sprays, sticks or aerosols.
  • Daily-care compositions with UV protection protect against damages on human skin by UV light.
  • Oil soluble filters have a solubility in specific emollients of at least 2.0 % by weight, preferably at least 3.0 % by weight, more preferably at least 5.0 % by weight.
  • SPF sunscreen protection factor
  • the term “sun protection factor (SPF)” as used herein indicates how well the skin is protected by a sunscreen composition mainly from UV-B radiation.
  • the SPF can be measured in vivo using an application amount of 2 mg/cm2 (ISO 24444, in particular ISO 24444:2019) or in vitro using for example transmittance measurements through a UV transparent substrate or in silico, for example using the BASF sunscreen simulator (https://sunscreensimulator.basf.com/Sunscreen Simulator/login).
  • the calculation method for the SPF is also described in the model published by B. Herzog et al. in Simulation of sunscreen performance, Pure Appt. Chem. 2015; 87(9-10):937-951.
  • broadband protection also referred to as broad-spectrum or broad protection
  • UV-B and UV-A protection must be provided.
  • a critical wavelength of at least 370 nm is required for achieving broad spectrum protection.
  • SPDF labelled sun protection factor
  • solid granular material refers to a material made up of a collection of discrete solid and macroscopic particles.
  • Solid granular materials have particular physical properties. The solid, macroscopic particles are surrounded by a gas or a liquid. Due to the size of the solid granular material, the ratio of the volume of the solid to the fluid phase (liquid or gas) is high, meaning that the macroscopic particles are in close contact with one another.
  • Solid granular materials share properties typical for solids and liquids: granular materials can withstand deformation and form heaps like solids while also flowing like liquids and exhibiting compressibility such as fluids in general.
  • Solid granular materials are meta-stable in that they are in a static solid-like state as ground state but can flow like fluid when an energy source is provided. All motions of granular materials require an external source of energy to overcome the loss of energy in the particle interactions.
  • the term “liquid additive” as used herein refers to a volatile or non-volatile chemical liquid substance that introduces or improves certain properties to/of the solid granular material. The liquid additive may be introduced before or during the manufacturing process of the solid granular material.
  • liquid additive in accordance with the invention comprises or preferably consists of substances of the group selected from humectant, emollient, granulation liquid, and mixtures thereof.
  • humectant refers to a compound that promotes the attraction and retention of moisture.
  • humectant is used herein in its common meaning in the art.
  • granulation liquid refers to a volatile or non-volatile liquid added to amend the shape, size, surface area and/or density of powders in order to improve their physicochemical properties and handling.
  • the granulation liquid facilitates the wetting and the agglomeration of the blend in the preparation of the solid granular material. In this manner, the granulation liquid provides the blend with optimal properties for the formation of a granular material.
  • emollient refers to a compound that softens the skin and provides a protective barrier that prevents dryness.
  • emollient is used herein in its common meaning in the art.
  • carrier refers to a compound that provides a general structure to the solid granular material.
  • the carrier holds the other components of the solid granular material together without reacting with them or external components.
  • carrier carrier material
  • matrix material are used interchangeably herein.
  • surfactant refers to surface active agents that decrease the surface tension or the interfacial tension between two phases, e.g. two liquids, a gas and a liquid or a liquid and a solid.
  • surfactants also: surface-active agents
  • amphiphilic molecules which comprise a nonpolar, hydrophobic portion (typically a straight or branched hydrocarbon chain containing between eight and 26 carbon atoms) which is attached to a polar hydrophilic portion.
  • the hydrophilic portion can be nonionic, ionic, or zwitterionic, and may be accompanied by counterions in case of the ionic or zwitterionic portion.
  • a typical mode of action of a surfactant is that the surfactant molecule orients itself at the interface between two phases with the hydrophobic portion oriented towards the hydrophobic phase (e,g, air/oil) and the hydrophilic portion oriented towards the hydrophilic phase (e.g. aqueous solution). This typically results in a lowering of the surface tension or the interfacial tension.
  • surfactant is used herein in its common meaning in the art.
  • active agent refers to a compound in a cosmetic composition that helps preserve the skin, hair, or other body parts in their natural condition and to objectively modify or improve the condition of the skin, hair, or other body parts as well as to protect the skin, hair, or other body parts.
  • active agent is used herein in its common meaning in the art. Examples of such active agents are organic and/or inorganic UV filters, moisturizers, anti-aging agents, conditioning agents, protective proteins, enzymes, vitamins, retinol, or caffeine.
  • the liquid additive (a) comprises an emollient, wherein the solid granular material comprises the emollient in an amount of from 1.0 to 30.0 wt.%, based on the total weight of the solid granular material, and wherein the emollient is selected from the group consisting of propylene glycol dicaprylate/dicaprate, cocoglycerides, caprylic/capric triglyceride, isopropyl myristate, octyldodecyl myristate, decyl oleate, propylheptyl caprylate, isorbide dicaprylate, cetearyl isononanoate, caprylyl caprylate/caprate, pentaerythrityl tetraethylhexanoate, coco- caprylate/caprate, oley
  • the solid granular material of the invention results in a smooth, lump-free personal care product after dissolution.
  • the personal care products obtained from the inventive solid granular material provide a smooth feeling on the skin without any residual solid particles.
  • the personal care products can be obtained from the solid granular material by the end user by simply adding a dissolution solvent, in particular water, in the preferred quantity. In this manner, a large variety of different personal care products can be made from the general core structure of the solid granular material of the invention.
  • Possible personal care products that can be obtained encompass sunscreens, hair care products, conditioners, face care products, make-up products, body lotion and toothpaste. Due to the high level of flexibility regarding the further ingredients and the possibility of producing even small charges of material, it is possible to provide highly personalized and specialized personal care products.
  • solid granular material described herein allows for the direct preparation of personal care products that are emulsions.
  • the solid granular material of the invention has a long shelf-life and allows for the use of water-sensitive components.
  • the concentrated form of the solid granular materials reduces transport costs and makes transportation more ecological due to the reduced transportation weight.
  • the solid granular material of the invention results in a reduced use of plastic containers. Due to the higher stability, the need for preservatives is also reduced.
  • the inventive solid granular material comprises at least three components: (a) 1.0 to 30.0 wt.% of a liquid additive, (b) 10.0 to 98.0 wt.% of a carrier and (c) 0.1 to 50.0 wt.% of a surfactant, wherein the liquid additive (a) comprises an emollient and wherein the emollient is selected from the group consisting of propylene glycol dicaprylate/dicaprate, cocoglycerides, caprylic/capric triglyceride, isopropyl myristate, octyldodecyl myristate, decyl oleate, propylheptyl caprylate, isorbide dicaprylate, cetearyl isononanoate, caprylyl caprylate/caprate, pentaerythrityl tetraethylhexanoate, coco-caprylate/caprate, oleyl erucate, is
  • the inventive solid granular material comprises 1.0 to 30.0 wt.% of a liquid additive, based on the total weight of the solid granular material.
  • the liquid additive facilitates and assists in the formation of the granular material from a blend.
  • the liquid additive is further required for the structural integrity and stability of the granular material of the invention.
  • the liquid additive (a) comprises an emollient.
  • the solid granular material comprises the emollient in an amount of from 1.0 to 30.0 wt.%, based on the total weight of the solid granular material.
  • the emollient is selected from the group consisting of propylene glycol dicaprylate/dicaprate, cocoglycerides, caprylic/capric triglyceride, isopropyl myristate, octyldodecyl myristate, decyl oleate, propylheptyl caprylate, isorbide dicaprylate, cetearyl isononanoate, caprylyl caprylate/caprate, pentaerythrityl tetraethylhexanoate, coco- caprylate/caprate, oleyl erucate, isononyl isononanoate, methyl soyate, dibutyl adipate, di
  • the use of the emollient allows for the preparation of an emulsion-type personal care product.
  • Particularly preferred emollients according to the present invention are selected from C12-15 alkyl benzoate, caprylic/capric triglyceride, dibutyl adipate, propylheptyl caprylate, dicaprylyl carbonate and mixtures thereof, most preferred dicaprylyl carbonate.
  • Particularly preferred quantities of emollient in the solid granular material are from 0.5 to 25.0 wt.%, preferably from 2.0 to 20.0 wt.%, further preferred from 3.0 to 15.0 wt.%, and even more preferred from 3.5 to 10 wt.%, based on the total weight of the solid granular material.
  • conditioning agents include volatile or non-volatile silicone fluids such as dimethicone copolyol, dimethylpolysiloxane, diethylpolysiloxane, mixed Cl-30 alkyl polysiloxanes, phenyl dimethicone, dimethiconol, dimethicone, dimethiconol, silicone crosspolymers, and combinations thereof.
  • Typical conditioning agents for hair care products can be used in the inventive solid granular material.
  • the active agent (d) of the granular material is an anti-aging agent.
  • Typical anti-aging agents include retinol derivatives, peptides that improve collagen production, hyaluronic acid, vitamin C, coenzyme Q10, niacinamide (vitamin B3), nicotinamide riboside, nicotinamide mononucleotide, a -hydroxy acids, in particular glycolic acid and lactic acid, ? -hydroxy acids, in particular salicylic acid, resveratrol, epidermal growth factors, curcumin, epigallocatechin gallate, and crocin. It is also preferred that the active agent (d) is an anti-oxidant agent.
  • Typical anti-oxidant agents comprise amino acids (e.g., glycine, histidine, tyrosine, and tryptophan) and derivatives thereof, imidazoles (e.g. urocanic acid) and derivatives thereof, peptides (e.g., D,L-carnosine, D-carnosine, and L-carnosine) and derivatives thereof (e.g., anserine), carotenoids, carotenes (e.g., a-carotene, 13-carotene, and y-lycopene) and derivatives thereof, chlorogenic acid and derivatives thereof, aurothioglucose, propylthiouracil and other thiols (e.g., thioredoxin, glutathione, cysteine, cystine, cystamine and the glycosyl, N- acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmito
  • compositions (d) for the solid granular material for use in the preparation of a personal care product include protective proteins, enzymes, vitamins, retinol, ferulic acid, vanillin, and caffeine.
  • the method to determine the dissolution properties of the material encompass providing 36 g of water in a beaker and adding 4 g of solid granular material while stirring. Subsequently, the mixture of solid granular material in water is homogenized with a four-blade agitator at a share rate of 200/s at 23 ° C.
  • the solid granular material which is preferably in the form of an extruded granule is further sphere-shaped or rodshaped. It is particularly preferred that the ratio of the length in mm to the diameter in mm of the solid granular material is from 1 to 20.
  • the solid granular material for use in the preparation of a personal care product is for use in the preparation of a leave-on personal care product.
  • the method further comprises the step of spheronization of the wet pellets obtained in d. before the drying step e. to obtain sphere- or rod-shaped wet pellets.
  • the invention relates to a kit-in-part comprising at least a first inventive solid granular material and a second inventive solid granular material for the preparation of a personal care product.
  • inventive solid granular material is the possibility to provide personalized personal care products. This can be done by combining different solid granular materials of the present invention with one another. In this manner, a broad range of modified personal care products can be obtained.
  • the first and the second inventive solid granular material must differ in at least one aspect, for example in the components of the material or the ratio of the components. There is no limitation on how many different solid granular materials can be combined in the inventive kit-in-parts, however, typical numbers may range from two to five, in particular from two to four different solid granular materials.
  • a premix 1 was prepared by mixing together 1 g caprylic/capric triglyceride (emollient; Myritol® 312 from BASF Care creations), 4 g cetrimonium chloride (conditioning agent; Dehydquart A-CA from BASF Care creations), 0.4 g linalool (perfume, BASF care creations), 0.5 g sodium benzoate (preservative, Sigma Aldrich, p.a.) and 0.1 g citric acid (pH adjustment). Cetearyl alcohol (surfactant; Lanette® 0 from BASF Care creations) was melted separately and 3.5 g of the melted cetearyl alcohol was added to the premix 1.
  • earyl alcohol surfactant; Lanette® 0 from BASF Care creations
  • the mixture was left to cool to room temperature and then extruded using a Caleva Multilab (CML) extrusion system comprising a multi-die plate with 26 holes with a 1 mm diameter at a rotation speed of approximately 100 rpm.
  • CML Caleva Multilab
  • the extrudates obtained were brittle and it was not possible to spheronize them due to the brittleness of the extrudates.
  • the extrudates were dried overnight in a fume hood.
  • redispersion trial 1.2 g granules were mixed with 18.8 g warm water (-40° C) and mixed by hand and additionally gently homogenized on a roller mixer.
  • the redispersed material was liquid with a low viscosity.
  • the redispersed material did not provide the same structure or feel as a basic conditioner prepared using standard preparation methods and was not suitable for use as hair conditioner.
  • phase C containing 0.3 wt.% perfume, 0.5 wt.% sodium benzoate (preservative) and adjusting the pH to below 5 using citric acid.
  • Example 2 Granules for hair conditioner (with carrier component)
  • a premix 1 was prepared with the same components as in comparative example 1.
  • cetearyl alcohol surfactant; Lanette® O from BASF Care creations
  • 1 g of a 1:1 (by weight) mixture of lactose (carrier; from Sigma Aldrich) and modified starch (carrier; Capsul® HF from Ingredion) was added to the warm mixture.
  • 4 x 1 g microcrystalline cellulose carrier; from Alfa Aesar
  • the mixture was homogenized in a mixer at 2000 rpm (Thinky® mixer model ARE-250).
  • the resulting mixture was left to cool to room temperature and then extruded using a Caleva Multilab (CML) extrusion system comprising a multi-die plate with 26 holes with a 1 mm diameter at a rotation speed of approximately 100 rpm.
  • CML Caleva Multilab
  • the extrudates obtained from the extrusion process were spheronized using the Caleva Multilab (CML) extrusion system and the resulting particles were dried in a fume hood overnight.
  • Example 3 Granules for face cream
  • a solid blend was prepared by milling 2.6 g alkyl polyglucoside (surfactant, Emulgade PL68/50 from BASF care creations) with 0.4 g sodium stearoyl glutamate (surfactant, Emulgin SG from BASF care creations), 1.3 g glyceryl stearate (consistency agent, Cutina GMS V from BASF care creations), 0.5 g xanthan gum (thickener, Rheocare® XGN from BASF care creations), 0.5 g sodium benzoate (preservative), and 0.2 g citric acid (pH adjustment) in an IKA multidrive system.
  • surfactant Emulgade PL68/50 from BASF care creations
  • sodium stearoyl glutamate surfactant, Emulgin SG from BASF care creations
  • 1.3 g glyceryl stearate consististency agent, Cutina GMS V from BASF care creations
  • the solid blend was transferred to a planetary mixter (Thinky® mixer model ARE-250) and 6.9 g dicaprylyl carbonate (emollient, Cetiol® CC from BASF care creations) was added and the mixtures was mixed to obtain a premix 1.
  • a planetary mixter Thinky® mixer model ARE-250
  • dicaprylyl carbonate emollient, Cetiol® CC from BASF care creations
  • the mixture was humidified prior to the extrusion process by adding 1.5 g deionized water (granulation liquid). Subsequently, the humidified mixture was extruded using a Caleva Multilab (CML) extrusion system comprising a multi-die plate with 26 holes with a 1 mm diameter at a rotation speed of approximately 100 rpm. The same system was used to spheronize the extruded product. After spheronization, the particles were dried overnight in a fume hood.
  • CML Caleva Multilab
  • Example 4 Granules for sunscreen with water
  • a premix 1 was prepared by mixing 2.5 g lactose (carrier) with 10 g 2-phenylbenzimidazole- 5-sulfonic acid (PBSA, UV filter, Eusolex® 232 from Merck KGaA), 3 g sodium carbonate (pH adjustment), and 1 g xanthan gum (thickener; Rheocare® XGN from BASF care creations) in a stand mixer.
  • a premix 2 comprising 0.13 g polysorbate 80 (surfactant, Tween® 80), 0.12 g sorbitan monooleate (surfactant, Span® 80), and 0.75 g Caprylic/capric triglycerides (emollient, Miglyol® 812) was prepared and added to the premix 1. 3 g water (granulation liquid) was added stepwise to the mixture.
  • the mixture was then extruded and spheronized using a Caleva Multilab (CML) extrusion system comprising a multi-die plate with 26 holes with a 1 mm diameter at a rotation speed of approximately 100 rpm.
  • CML Caleva Multilab
  • the granules obtained were redispersed adding 16 g warm water (-40° C) to 4 g of granules by manual shaking. The granules dissolved well and resulted in a homogenous mixture, ready-to-use as sunscreen.
  • Example 5 Granules for sunscreen without water
  • a premix 1 was prepared by mixing 1.25 g lactose (carrier) with 5 g 2-phenylbenzimidazole- 5-sulfonic acid (PBSA, UV filter, Eusolex® 232 from Merck KGaA), 1.5 g sodium carbonate (pH adjustment), and 0.5 g xanthan gum (thickener; Rheocare® XGN from BASF care creations) in a stand mixer.
  • PBSA 2-phenylbenzimidazole- 5-sulfonic acid
  • PBSA 2-phenylbenzimidazole- 5-sulfonic acid
  • sodium carbonate pH adjustment
  • 0.5 g xanthan gum thicker; Rheocare® XGN from BASF care creations
  • a premix 2 comprising 0.06 g polysorbate 80 (surfactant, Tween® 80), 0.06 g sorbitan monooleate (surfactant, Span® 80), and 0.38 g Caprylic/capric triglyceride (emollient, Miglyol® 812) was prepared and added to the premix 1. 2.25 g dibutyl adipate (granulation liquid) was added stepwise to the mixture.
  • the mixture was then extruded and spheronized using a Caleva Multilab (CML) extrusion system comprising a multi-die plate with 26 holes with a 1 mm diameter at a rotation speed of approximately 100 rpm.
  • CML Caleva Multilab
  • the granules obtained were redispersed adding 16 g warm water (-40° C) to 4 g of granules by manual shaking. The granules dissolved well and resulted in a homogenous mixture, ready-to-use as sunscreen.

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Abstract

La présente invention concerne un matériau granulaire solide destiné à être utilisé dans la préparation d'un produit de soins personnels, caractérisé en ce que le matériau granulaire solide comprend (a) 1,0 à 30,0% en poids d'additif liquide, (b) 10,0 à 98,0% en poids de support, (c) 0,1 à 50,0% en poids de tensioactif, (d) éventuellement jusqu'à 70,0% en poids d'agent actif, chacun sur la base du poids total du matériau granulaire solide, un procédé de préparation d'un tel matériau granulaire solide ainsi qu'un kit en partie comprenant au moins un premier matériau granulaire solide et un second matériau granulaire solide, l'additif liquide (a) comprenant un émollient, le matériau granulaire solide comprenant l'émollient en une quantité de 1,0 à 30,0% en poids, sur la base du poids total du matériau granulaire solide, et l'émollient étant choisi dans le groupe constitué par le dicaprylate/dicaprate de propylène glycol, , les cocoglycérides, le triglycéride caprylique/caprique, le myristate d'isopropyle, le myristate d'octyldodécyle, l'oléate de décyle, le caprylate de propylheptyle, le dicaprylate d'isorbide, l'isononanoate de cétéaryle, le caprylate/caprate de caprylyle, le tétraéthylhexanoate de pentaérythrityle, le coco-caprylate/caprate, l'érucate d'oléyle, l'isononanoate d'isononyle, le soja méthyle, l'adipate de dibutyle, l'adipate de dibutyle étant supérieur à 50% d'origine biologique, le benzoate d'alkyle en C12-15, le laurate d'hexyle, le stéarate d'éthylhexyle, le palmitate d'éthylhexyle, le palmitate de cétyle, le myristate de myristyle, l'éther stéarylique de PPG-15, le coco-caprylate, le laurate d'hexyldécyle, le lactate de lauryle, le sébacate de dibutyle, le stéarate d'hexyldécyle, l'octyldodécanol, l'hexyldécanol, le tridécane, l'undécane, le n-dodécane, le squalane, l'isododécane, l'isohexadécane, l'éther de dicaprylyle, le carbonate de dicaprylyle, le carbonate de dipropylheptyle, le beurre de butyrospermum parkii (karité), l'huile d'olive pure, l'huile de graines de passiflore incarnata, et leurs mélanges.
PCT/EP2024/085746 2023-12-14 2024-12-11 Matériau granulaire solide pour la préparation de produits de soins personnels Pending WO2025125362A1 (fr)

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006741A2 (fr) 1978-06-23 1980-01-09 HENKEL CORPORATION (a Delaware corp.) Base cosmétique auto-émulsifiante
EP0754448A1 (fr) 1995-07-10 1997-01-22 L'oreal Composition sous forme de poudre auto-émulsionnable dans l'eau
JP2005343844A (ja) 2004-06-04 2005-12-15 Nisshin Oillio Group Ltd 自己乳化型油性固形状化粧料
US20110081392A1 (en) * 2008-06-20 2011-04-07 De Arruda Renato Shampoo Compositions
EP2664319A1 (fr) * 2011-01-12 2013-11-20 Kao Corporation Procédé de fabrication d'une composition effervescente d'agent pour le bain
US20180193231A1 (en) * 2015-06-30 2018-07-12 Amorepacific Corporation Fast disintegrating granular hair cleansing composition
US20210137800A1 (en) * 2017-06-30 2021-05-13 L'oreal Anhydrous solid composition comprising an isethionic acid derivative, a glutamic acid derivative, an amphoteric surfactant and fillers
FR3117023A1 (fr) * 2020-12-03 2022-06-10 L'oreal Composition solide anhydre comprenant l’association particulière d’un tensioactif sulfaté et d’un tensioactif amphotère
US20220273528A1 (en) * 2019-07-10 2022-09-01 Henkel Ag & Co. Kgaa Solid hair conditioning compositions

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006741A2 (fr) 1978-06-23 1980-01-09 HENKEL CORPORATION (a Delaware corp.) Base cosmétique auto-émulsifiante
EP0754448A1 (fr) 1995-07-10 1997-01-22 L'oreal Composition sous forme de poudre auto-émulsionnable dans l'eau
JP2005343844A (ja) 2004-06-04 2005-12-15 Nisshin Oillio Group Ltd 自己乳化型油性固形状化粧料
US20110081392A1 (en) * 2008-06-20 2011-04-07 De Arruda Renato Shampoo Compositions
EP2664319A1 (fr) * 2011-01-12 2013-11-20 Kao Corporation Procédé de fabrication d'une composition effervescente d'agent pour le bain
US20180193231A1 (en) * 2015-06-30 2018-07-12 Amorepacific Corporation Fast disintegrating granular hair cleansing composition
US20210137800A1 (en) * 2017-06-30 2021-05-13 L'oreal Anhydrous solid composition comprising an isethionic acid derivative, a glutamic acid derivative, an amphoteric surfactant and fillers
US20220273528A1 (en) * 2019-07-10 2022-09-01 Henkel Ag & Co. Kgaa Solid hair conditioning compositions
FR3117023A1 (fr) * 2020-12-03 2022-06-10 L'oreal Composition solide anhydre comprenant l’association particulière d’un tensioactif sulfaté et d’un tensioactif amphotère

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A. GIOIA: "Intrinsic flowability.- a new technology for powder-flowability classification", PHARMACEUTICAL TECHNOLOGY MAGAZINE, February 1980 (1980-02-01)
B. HERZOG ET AL.: "Simulation of sunscreen performance", PURE APPL. CHEM., vol. 87, no. 9-10, 2015, pages 937 - 951

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