WO2025118864A1 - Flash-release throat soothing composition, preparation method therefor, and use thereof - Google Patents

Abstract

A flash-release throat soothing composition, a preparation method therefor, and a use thereof. The flash-release throat soothing composition is prepared from the following raw materials: traditional Chinese medicine components, polyhydric sugar alcohol, and starch, wherein the mass ratio of the starch to the polyhydric sugar alcohol is 1:(0.5-1.6). The flash-release throat soothing composition is prepared by compounding polyhydric sugar alcohol and starch according to a specific mass ratio, pre-mixing, granulating, then mixing with other materials, performing wet granulation, and further adopting a wet granulation mode comprising first performing low-temperature drying treatment and then performing high-temperature drying and sterilization. The flash-release throat soothing composition does not contain any binder and disintegrating agent.

Description

A flash-release throat moistening composition and its preparation method and application

Priority claim: The present invention claims priority to Chinese patent application 2023116624748 filed on December 6, 2023, the entire contents of which are incorporated herein by reference.

Technical Field

The invention belongs to the technical field of food preparations, and in particular relates to a flash-release throat moistening composition and a preparation method and application thereof.

Background Art

In the era of health preservation and changes in modern people's health awareness and behavior, the categories and market demand of functional foods with specific nutritional and health functions are gradually expanding. For solid beverage products with carrying properties, combining them with functional nutritional ingredients such as Chinese medicinal materials that are both medicinal and edible is a better choice to conform to future health trends. Throat lozenges have the effects of cooling and relieving fever, anti-inflammatory and analgesic, relieving throat and refreshing. Using throat lozenges can stimulate the salivary glands, promote saliva secretion, and relieve throat discomfort to a certain extent.

Patent CN107007655A discloses a compound Coral Grass lozenge, comprising 4-6 parts of Coral Grass extract, 2-4 parts of menthol extract, 1-3 parts of peppermint oil, 50-60 parts of sucrose, 10-20 parts of glucose syrup, 3-7 parts of shell powder-based quick dissolving agent, 9-11 parts of filler, 1-3 parts of lubricant and 2-4 parts of coating agent. The patent's Coral Grass lozenge has high dissolution efficiency in the oral cavity and can quickly relieve the discomfort caused by sore throat. However, the preparation process of the patent is complicated, and many types of auxiliary materials are used, which increases the cost. The effective ingredient dissolution time is long, and the quick dissolving effect cannot be achieved, and the throat discomfort cannot be quickly relieved.

Invention patent CN102100326B discloses compound Tibetan green fruit throat lozenges and a preparation method thereof, wherein the compound Tibetan green fruit throat lozenges include 4-12% Tibetan green fruit water extract, 1-4% green tea water extract, 7-12% polyethylene glycol 6000, 0.5-1.5% gum arabic, 70-85% sorbitol or erythritol or isomalt, and 0.3-3% sweetener. More auxiliary materials need to be added, which reduces the content of effective substances under the same specifications and increases the cost accordingly.

Invention patent CN110313597A discloses an instant-dissolving throat-soothing granule and a preparation method thereof. The instant-dissolving throat-soothing granule contains 20-50 parts of monk fruit, 20-50 parts of mint, 20-50 parts of platycodon, 20-50 parts of licorice, 10-30 parts of bitter almond, 10-100 parts of sugar alcohol, 20-40 parts of instant fruit powder, and 30-100 parts of starch. Disintegrant 3-10 parts, sweetener 0.05-0.3 parts, citric acid 0.1-0.8 parts, menthol 0.05-0.4 parts. The preparation process of this patent has strict conditions, complicated steps and high cost.

Currently, throat-soothing solid beverage products on the market take more than ten seconds to dissolve in artificial saliva or water, which cannot quickly relieve discomfort symptoms. In addition, the existing instant dissolution process is relatively complex and costly.

Therefore, there is an urgent need to develop a flash-release throat moistening composition with low cost, simple process, rapid dissolution, few types of auxiliary materials and good taste.

Summary of the invention

In order to solve the technical problems of high cost, complicated preparation process and poor instant dissolution effect, the object of the present invention is to provide a flash-release throat moistening composition and a preparation method thereof.

In order to achieve the above object, the present invention adopts the following technical solutions:

The invention provides a flash-release throat-soothing composition, which comprises the following raw materials: traditional Chinese medicine components, polysaccharide alcohol and starch.

Furthermore, the traditional Chinese medicine ingredients include liquorice, ginseng, bitter almond and platycodon.

Furthermore, the mass ratio of the starch to the polyol is 1:0.5-1.6.

Furthermore, the mass ratio of the starch to the polyol is 1:0.8-1.6.

Furthermore, the mass ratio of the starch to the polyol is 1:1 or 1.5.

Furthermore, the polyol is at least one of erythritol, xylitol and sorbitol.

Furthermore, the starch is potato starch and/or corn starch.

Furthermore, the flash-release throat moistening composition comprises the following raw materials, measured by weight: 2.25-5.25 parts of Chinese medicine powder or Chinese medicine extract, 40-55 parts of polysaccharide alcohol, and 40-60 parts of starch.

Furthermore, the Chinese medicine ingredient is Chinese medicine powder or Chinese medicine extract.

Furthermore, the mass ratio of licorice, ginseng, bitter almond and platycodon in the traditional Chinese medicine ingredients is 1-4: 0.01-0.5: 0.01-0.5: 0.01-0.25.

Furthermore, the flash-release throat soothing composition also includes the following raw materials: sweetener, menthol, and citric acid.

Furthermore, the flash-release throat soothing composition comprises the following raw materials, by weight: 2.25-5.25 parts of Chinese medicine powder or Chinese medicine extract, 40-55 parts of polysaccharide alcohol, 40-60 parts of starch, 3.5-6.5 parts of sweetener, 1.5-2.5 parts of menthol, and 1-1.25 parts of citric acid.

Furthermore, the sweetener is at least one of mogroside, sucralose, stevioside, sucrose and mannitol.

The present invention also provides a method for preparing the flash-release throat moistening composition, comprising the following steps:

S1. Weigh polyols and starch according to the formula, mix, granulate, granulate, and dry to obtain polyol-starch mixed pregranules;

S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, anhydrous citric acid according to the formula amount, mix them with the sugar alcohol-starch mixed pre-granulation in step S1, granulate, granulate, and dry to obtain a flash-release throat moistening composition.

Furthermore, the granulation in steps S1 and S2 is wet granulation.

Furthermore, in the wet granulation in step S1, the stirring speed is 100-300 rpm, the cutting speed is 1000-2500 rpm, the water addition amount is 5wt%-7.5wt%, the water inlet rate is 200-400rpm, and the temperature is 20-25°C.

Furthermore, in the wet granulation in step S2, the stirring speed is 100-300 rpm, the cutting speed is 1000-2500 rpm, the water addition amount is 5wt%-12.5wt%, the water inlet rate is 200-400rpm, and the temperature is 20-25°C.

Furthermore, the drying in step S1 is: drying at 40-50° C. for 0.5-1.5 h.

Furthermore, the drying in step S2 is: drying at 40-50° C. for 0.5-2.5 h, and then drying at 80-90° C. for 0.5-1 h.

The present invention also provides application of the flash-release throat moistening composition in preparing food, health care products or medicines for relieving throat discomfort.

The present invention also provides a flash-release product for relieving throat discomfort, comprising the flash-release throat moistening composition.

Furthermore, the dosage form of the product is granules or microcapsules, pills, powders or tablets.

Polysaccharide alcohols are easy to recrystallize. If they are directly mixed with other materials for wet granulation and then dried, the finished product will have obvious granular feeling and will be difficult to disintegrate in artificial saliva, and will not achieve the effect of instant dissolution. Starch is a water-soluble material. By making starch encapsulate polysaccharide alcohols to form a dispersed structure, the obtained particles have an instant dissolution effect. Water solubility can be guaranteed in the subsequent granulation process. Since it is a water-soluble material, the release rate in artificial saliva is less than two seconds, which has a flash release effect.

Starch is easily soluble in water and has hydroscopic properties. During the wet granulation process, it absorbs water and combines with sugar alcohol to form an inclusion compound. During the drying process, the moisture content is reduced, making the small particle group structure tighter and the particles more dispersed, preventing the sugar alcohol from recrystallizing and ensuring the dissolution rate.

It avoids the recrystallization of polyols, which may affect the dissolution of subsequent products and cause granular taste. At the same time, low-temperature drying can prevent the gelatinization properties of starch from changing and affecting the yield.

The beneficial effects of the present invention are:

The instant-release throat moistening composition of the present invention is prepared by pre-mixing and granulating polyols and starch according to a specific mass ratio, and then wet-granulating with other materials; and further adopting a wet-granulation method of first low-temperature drying and then high-temperature drying and sterilization to obtain the instant-release throat moistening composition. The sugar alcohol does not directly contact with other materials, and the instant-dissolving state can be ensured under the premise of ensuring the taste.

The flash-release throat moistening composition of the present invention helps to relieve pain in the throat, quickly relieves throat discomfort, and the cooling feeling reaches the throat instantly and lasts for a long time.

The invention has undergone rigorous formula and process research, does not contain any adhesives and disintegrants, has good taste, low cost, good instant dissolution effect, good throat moistening effect, simple preparation process and good formability on the basis of ensuring the content of effective ingredients.

DETAILED DESCRIPTION

The following describes the embodiments of the present invention through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention.

Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are for describing specific embodiments rather than for limiting the scope of protection of the present invention.

When the embodiment gives a numerical range, it should be understood that, unless otherwise specified in the present invention, the two endpoints of each numerical range and any numerical value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those of ordinary skill in the art to which the present invention belongs.

The present invention does not limit the source of the raw materials used. Unless otherwise specified, the raw materials used in the present invention are all common commercial products in the field of the art. Chinese herbal medicine powders are all directly crushed and sieved from Chinese herbal medicines. The standards for Chinese herbal medicine extracts and Chinese herbal medicine powders are tested in accordance with the first and fourth parts of _the 2020 edition of the Chinese Pharmacopoeia, and the results meet the requirements. The main components of licorice extract are liquiritin (C ₂₁ H ₂₂ O ₉ ) and glycyrrhizic acid (C ₄₂ H ₆₂ O ₁₆ ). Licorice extract is calculated on a dry basis and contains 0.50% liquiritin (C ₂₁ H ₂₂ O ₉ ) and 7.0% glycyrrhizic acid (C 42 H ₆₂ O ₁₆ ). The main component of ginseng extract is total ginsenosides. Ginseng extract is calculated on a dry basis and contains 65-70% total ginsenosides in terms of ginsenoside Re (C ₄₈ H ₈₂ O ₁₈ ). The main component of bitter almond extract is amygdalin (C ₂₀ H ₂₇ NO ₁₁ ). The bitter almond extract was purchased from Xi'an Beijinuo Biotechnology Co., Ltd. The main component of Platycodon grandiflorum extract is platycodon saponin, and the Platycodon grandiflorum extract was purchased from Shaanxi Tech Biotechnology Co., Ltd. with a specification of 20:1.

Example

Example 1

A flash-release throat moistening composition comprises, by weight: 45 parts of erythritol, 45 parts of potato starch, 2.2 parts of liquorice powder, 0.5 parts of ginseng extract, 0.5 parts of bitter almond powder, 0.05 parts of platycodon extract, 6.5 parts of sweetener, 2.5 parts of menthol, and 1.25 parts of citric acid.

The preparation method of the flash-release throat moistening composition comprises the following steps:

S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 200 rpm, cutting knife speed 2000 rpm, water addition amount 5.5 wt%, water inlet rate 200 rpm, temperature 25°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 40°C for 0.5 h to obtain a sugar alcohol-starch mixed pregranulation;

S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, citric acid according to the formula amount, mix with the sugar alcohol-starch mixed pre-granules described in step S1, and put them into a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 200 rpm, cutting knife speed 2000 rpm, water addition amount 10.5wt%, water inlet rate 200 rpm, temperature 25° C. After stirring, the materials are added to a granulator for granulation. After granulation, they are dried at 45° C. for 1 hour, and then heated to 85° C. and dried for 0.5 hour to obtain a flash-release throat moistening composition.

Example 2

A flash-release throat moistening composition comprises, by weight: 55 parts of erythritol, 50 parts of potato starch, 2.35 parts of liquorice extract, 0.2 parts of ginseng powder, 0.2 parts of bitter almond powder, 0.25 parts of platycodon powder, 6.5 parts of sweetener, 2.5 parts of menthol, and 1.25 parts of citric acid.

The preparation method of the flash-release throat moistening composition comprises the following steps:

S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 200 rpm, cutting knife speed 2000 rpm, water addition amount 5.5 wt%, water inlet rate 200 rpm, temperature 25°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 50°C for 1.5 hours to obtain a sugar alcohol-starch mixed pregranulation;

S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula amount, mix them with the sugar alcohol-starch mixed pre-granules described in step S1, and put them into a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 200 rpm, cutting knife speed 2000 rpm, water addition amount 10.5 wt%, water inlet rate 200 rpm, temperature The temperature is 25°C. After stirring, the material is added to a granulator for granulation, and then dried at 50°C for 0.5h, and then heated to 90°C and dried for 0.5h.

Example 3

A flash-release throat moistening composition comprises, by weight: 40 parts of xylitol, 60 parts of potato starch, 4 parts of liquorice powder, 0.5 parts of ginseng extract, 0.5 parts of bitter almond powder, 0.25 parts of platycodon powder, 6.5 parts of sweetener, 2.5 parts of menthol, and 1.25 parts of citric acid.

The preparation method of the flash-release throat moistening composition comprises the following steps:

S1. Weigh the polyol and starch according to the formula, mix them, and add them to the wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 250rpm, cutting knife speed 1500rpm, water addition amount 7.5wt%, water inlet rate 300rpm, temperature 20°C. After stirring, add the materials to the granulator for granulation. After granulation, dry them at 50°C for 1.5h to obtain the sugar alcohol-starch mixed pregranules;

S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula amount, mix with the sugar alcohol-starch mixed pre-granules in step S1, and put them into a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 200 rpm, cutting knife speed 2000 rpm, water addition amount 10.5wt%, water inlet rate 200 rpm, temperature 25° C. After stirring, the materials are added to a granulator for granulation. After granulation, the granules are dried at 50° C. for 0.5 h, then heated to 90° C. and dried for 0.5 h.

Example 4

A flash-release throat moistening composition comprises, by weight: 45 parts of erythritol, 50 parts of corn starch, 3.72 parts of liquorice powder, 0.01 parts of ginseng extract, 0.01 parts of bitter almond extract, 0.01 parts of platycodon extract, 6.5 parts of sweetener, 2.5 parts of menthol, and 1.25 parts of citric acid.

The preparation method of the flash-release throat moistening composition comprises the following steps:

S1. Weigh the polyol and starch according to the formula, mix them, and add them to the wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 250rpm, cutting knife speed 1500rpm, water addition amount 7.5wt%, water inlet rate 300rpm, temperature 20°C. After stirring, add the materials to the granulator for granulation. After granulation, dry them at 50°C for 1.5h to obtain the sugar alcohol-starch mixed pregranules;

S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula amount, mix them with the sugar alcohol-starch mixed pre-granules described in step S1, and put them into a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 200 rpm, cutting knife speed 2000 rpm, water addition amount 10.5 wt%, water inlet rate 200 rpm, temperature The temperature is 25°C. After stirring, the material is added to a granulator for granulation, and then dried at 50°C for 0.5h, and then heated to 90°C and dried for 0.5h.

Example 5

A flash-release throat moistening composition comprises, by weight, 50 parts of sorbitol, 40 parts of corn starch, 3.2 parts of liquorice extract, 0.4 parts of ginseng powder, 0.3 parts of bitter almond powder, 0.1 parts of platycodon extract, 6.5 parts of sweetener, 2.5 parts of menthol, and 1.25 parts of citric acid.

The preparation method of the flash-release throat moistening composition comprises the following steps:

S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 250 rpm, cutting knife speed 1500 rpm, water addition amount 6.5 wt%, water inlet rate 300 rpm, temperature 20°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 45°C for 1 hour to obtain a sugar alcohol-starch mixed pregranulation;

S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula amount, mix with the sugar alcohol-starch mixed pre-granules in step S1, and put them into a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 200 rpm, cutting knife speed 2000 rpm, water addition amount 10.5wt%, water inlet rate 200 rpm, temperature 25° C. After stirring, the materials are added to a granulator for granulation. After granulation, the granules are dried at 45° C. for 1 hour, then heated to 85° C. and dried for 0.5 hour.

Example 6

A flash-release throat moistening composition comprises, by weight: 45 parts of erythritol, 45 parts of potato starch, 2.2 parts of liquorice powder, 0.5 parts of ginseng extract, 0.5 parts of bitter almond powder, 0.05 parts of platycodon extract, 5.5 parts of sweetener, 2.5 parts of menthol, and 1.25 parts of citric acid.

The preparation method of the flash-release throat moistening composition comprises the following steps:

S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 250 rpm, cutting knife speed 1500 rpm, water addition amount 6.5 wt%, water inlet rate 300 rpm, temperature 20°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 45°C for 1 hour to obtain a sugar alcohol-starch mixed pregranulation;

S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula amount, mix them with the sugar alcohol-starch mixed pre-granules described in step S1, and put them into a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 200 rpm, cutting knife speed 2000 rpm, water addition amount 10.5 wt%, water inlet rate 200 rpm, temperature The temperature is 25℃. After stirring, the material is added to a granulator for granulation. After granulation, it is dried at 45℃ for 1h, then heated to 85℃ and dried for 0.5h.

Example 7

A flash-release throat moistening composition comprises, by weight: 45 parts of erythritol, 45 parts of potato starch, 2.2 parts of liquorice powder, 0.5 parts of ginseng extract, 0.5 parts of bitter almond powder, 0.05 parts of platycodon extract, 3.5 parts of sweetener, 1.5 parts of menthol, and 1 part of citric acid.

The preparation method of the flash-release throat moistening composition comprises the following steps:

S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 100 rpm, cutting knife speed 1500 rpm, water addition amount 5.5 wt%, water inlet rate 300 rpm, temperature 20°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 45°C for 1 hour to obtain a sugar alcohol-starch mixed pregranulation;

S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula amount, mix with the sugar alcohol-starch mixed pre-granules in step S1, and put them into a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 200 rpm, cutting knife speed 2000 rpm, water addition amount 12.5wt%, water inlet rate 200 rpm, temperature 25° C. After stirring, the materials are added to a granulator for granulation. After granulation, the granules are dried at 45° C. for 1 hour, then heated to 85° C. and dried for 0.5 hour.

Example 8

A flash-release throat moistening composition comprises, by weight: 45 parts of erythritol, 45 parts of potato starch, 1 part of liquorice powder, 0.5 parts of ginseng extract, 0.5 parts of bitter almond powder, 0.25 parts of platycodon extract, 4.5 parts of sweetener, 1.5 parts of menthol, and 1 part of citric acid.

The preparation method of the flash-release throat moistening composition comprises the following steps:

S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 100 rpm, cutting knife speed 1500 rpm, water addition amount 5.5 wt%, water inlet rate 300 rpm, temperature 20°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 45°C for 1 hour to obtain a sugar alcohol-starch mixed pregranulation;

S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula amount, mix them with the sugar alcohol-starch mixed pre-granules described in step S1, and put them into a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 200 rpm, cutting knife speed 2000 rpm, water addition amount 12.5wt%, water inlet rate 200 rpm, temperature The temperature is 25℃. After stirring, the material is added to a granulator for granulation. After granulation, it is dried at 45℃ for 1h, then heated to 85℃ and dried for 0.5h.

Example 9

A flash-release throat moistening composition comprises, by weight, 53 parts of erythritol, 35 parts of potato starch, 3 parts of liquorice powder, 0.1 parts of ginseng extract, 0.1 parts of bitter almonds, 0.1 parts of platycodon extract, 5.5 parts of sweeteners, 2.5 parts of menthol, and 1 part of citric acid.

The preparation method of the flash-release throat moistening composition comprises the following steps:

S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 200 rpm, cutting knife speed 2000 rpm, water addition amount 7.5wt%, water inlet rate 200 rpm, temperature 25°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 40°C for 0.5h to obtain a sugar alcohol-starch mixed pregranulation;

S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, citric acid according to the formula amount, mix with the sugar alcohol-starch mixed pre-granules described in step S1, and put them into a wet granulator for stirring. The parameters of the wet granulator are as follows: stirring speed 200 rpm, cutting knife speed 2000 rpm, water addition amount 12.5wt%, water inlet rate 200 rpm, temperature 25° C. After stirring, the materials are added to a granulator for granulation. After granulation, they are dried at 45° C. for 1.5 hours, and then heated to 85° C. and dried for 0.5 hours to obtain a flash-release throat moistening composition.

Example 10

A flash-release throat moistening composition comprises, by weight: 51 parts of erythritol, 34 parts of potato starch, 5 parts of liquorice powder, 0.5 parts of ginseng extract, 0.5 parts of bitter almond powder, 0.5 parts of platycodon extract, 5.5 parts of sweetener, 2.5 parts of menthol, and 1 part of citric acid.

The preparation method is the same as Example 9.

Embodiment 11

A flash-release throat moistening composition comprises, by weight: 54 parts of erythritol, 36 parts of potato starch, 1 part of liquorice powder, 0.01 parts of ginseng extract, 0.1 parts of bitter almond powder, 0.1 parts of platycodon extract, 5.5 parts of sweetener, 2.5 parts of menthol, and 1 part of citric acid.

The preparation method is the same as Example 9.

Comparative Example

Comparative Example 1

The difference between this comparative example and Example 1 is that potato starch is not used, and the preparation method does not carry out the pre-granulation step S1.

Comparative Example 2

The difference between this comparative example and Example 1 is that erythritol is not used, and the preparation method does not carry out the pre-granulation step S1.

Comparative Example 3

The difference between this comparative example and Example 1 is that the weight ratio of potato starch to erythritol is different; specifically, the weight ratio of potato starch to erythritol is 1:2, wherein the weight portion of potato starch is 30 parts, and the weight portion of erythritol is 60 parts.

Comparative Example 4

The difference between this comparative example and Example 1 is that the weight ratio of potato starch to erythritol is different; specifically, the weight ratio of potato starch to erythritol is 1:0.4, wherein the weight portion of potato starch is 60 parts and the weight portion of erythritol is 24 parts. During the wet granulation process, the amount of water added is increased to 13%, and the drying time in step S1 is extended to 3 hours.

Comparative Example 5

The difference between this comparative example and Example 1 is that the preparation method is different; specifically, step S1 is not performed, all the raw and auxiliary materials are mixed and then directly wet granulated, the materials after wet granulation are granulated, and after granulation, they are dried at 45°C for 1 hour and then dried at 85°C for 0.5 hour.

Comparative Example 6

The difference between this comparative example and Example 1 is that the drying process is different. Specifically, the drying process in step S2 is drying at 60° C. for 2 hours.

Comparative Example 7

The difference between this comparative example and Example 1 is that the wet granulation process is different. Specifically, the amount of water added in step S2 in the wet granulation process is 20 wt %.

Comparative Example 8

The difference between this comparative example and Example 1 is that the dosage of the Chinese herbal medicine components is different; specifically, the Chinese herbal medicine extract is 10 parts by weight.

Comparative Example 9

The difference between this comparative example and Example 1 is that the amount of menthol used is different; specifically, the menthol is 3 parts by weight.

Comparative Example 10

The difference between this comparative example and Example 1 is that the dosage of menthol and the dosage of the Chinese herbal medicine extract are different; specifically, the dosage of menthol is 0.5 parts by weight and the dosage of the Chinese herbal medicine extract is 3 parts by weight.

Comparative Example 11

Jin Xiaocao Throat Soothing Treasure, purchased from Shanghai Jianshun Biotechnology Co., Ltd., product standard code Q/HSHLY 0001S, product patent number ZL201711013148.9

Comparative Example 12

The "30 parts of instant fruit powder, sugar alcohol (70 parts of sorbitol, 10 parts of mannitol), 40 parts of potato starch, disintegrant (4 parts of sodium carboxymethyl starch, 1 part of polyvidone), sweetener (0.15 parts of stevioside, 0.05 parts of sucralose), 0.6 parts of citric acid, 0.3 parts of menthol" in Example 1 of CN110313597A are used instead of the "45 parts of erythritol, 45 parts of potato starch, 5.5 parts of sweetener, 2.5 parts of menthol, 1.25 parts of citric acid" in Example 1 of the present application.

Effect performance test

1. Evaluation of the physical and chemical properties of the flash-release throat moistening composition

1. Experimental Methods

1.1 Evaluation of dissolution time

Using the dissolution time (in artificial saliva and in water at room temperature) as an indicator, Examples 1-11 and Comparative Examples 1-5 and Comparative Examples 8-12 were evaluated.

1.2 Formability evaluation

Examples 1-11 and Comparative Examples 1-10 were evaluated based on formulation formability.

1.3 Oral Sensitivity Evaluation

For Examples 1-11, Comparative Examples 1-5 and Comparative Examples 8-12, 20 sensory evaluation personnel were selected to evaluate the four indicators of solubility (dissolution in artificial saliva), solubility (in water at room temperature), mouthfeel, and throat moistening effect.

2. Experimental results

2.1 Evaluation of dissolution time

The results of dissolution time for Examples 1-11, Comparative Examples 1-5, and Comparative Examples 8-12 are shown in Table 1. It can be seen from the table that the instant dissolution effect of the embodiments is good, and the dissolution time in artificial saliva is between 1.56s and 1.85s, and Example 1 only takes 1.56s to dissolve in artificial saliva; the embodiments have good dissolution effect in normal temperature water, quickly disperse in water, and dissolve quickly after stirring, requiring only less than 2s. However, Comparative Examples 1-5 and Comparative Examples 11-12 take a long time to dissolve in artificial saliva, among which Comparative Example 1 has the longest dissolution time in artificial saliva, which is 23.18s. Comparative Examples 1, 3, 4, and 11 have poor dissolution effects in normal temperature water, among which Comparative Examples 1, Comparative Example 3, Comparative Example 4, and Comparative Example 11 still have residues at the bottom of the beaker after stirring, and Comparative Example 1 has the worst effect. The specific mass ratio of erythritol and starch changes, resulting in poor instant dissolution effect.

Table 1

2.2 Formability evaluation

The formulation formability of Examples 1-11 and Comparative Examples 1-10 was evaluated, and the results are shown in Table 2. As can be seen from the results in Table 2, the molding effects of Examples 1-11, Comparative Examples 5 and Comparative Examples 8-10 are good. However, the molding effect of Comparative Examples 1-4 is not good, and Comparative Examples 6-7 cannot be molded. Among them, when the mass ratio of erythritol in Comparative Example 3 is too high, the mixture cannot ensure a uniformly dispersed state, resulting in an increase in the contact area between erythritol molecules during wet drying and an increase in the crystallization rate. In Comparative Example 4, the mass ratio of starch is too high, and the amount of water needs to be increased during wet granulation, resulting in the need to extend the drying time in the subsequent steps, and a gelatinized and unformed state is likely to occur in step S2. Comparative Example 6 experienced starch gelatinization during the drying process and could not be molded. Comparative Example 7 experienced agglomeration during the whole granulation process, and starch gelatinization occurred during the subsequent drying process, and could not be molded.

Table 2

2.3 Comprehensive Evaluation

The evaluation results of solubility (in artificial saliva), solubility (in water at room temperature), taste, and throat moistening effect are shown in Table 3. It can be seen from the table that the dissolution effect of the embodiment is good, the taste is good, there is no bitterness, and the throat discomfort can be quickly relieved after use, and the effect is better for smokers. Comparative Example 11 has a slightly bitter taste, a distinct astringent taste after entering the mouth, poor patient compliance, poor dissolution effect, 7.25s is required for dissolution in artificial saliva, and there is still powder residue after stirring in water at room temperature, and the throat moistening effect is slow to relieve throat discomfort.

Table 3

3. Conclusion

The instant-release throat moistening composition of the present invention is compounded with polyols and starch, and has a better instant dissolving effect. The starch and polyols are first pre-mixed and granulated, and then mixed with other materials for wet granulation and then dried at low temperature. By compounding the raw materials, a instant-release throat moistening composition with low cost, good instant dissolving effect, good taste, rapid relief of throat discomfort, and long-lasting drug effect is prepared.

The above is a further description of the present invention in conjunction with specific embodiments, but these embodiments are merely exemplary and do not constitute any limitation on the scope of the present invention. It should be understood by those skilled in the art that the details and forms of the technical solution of the present invention may be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the scope of protection of the present invention.

Claims (14)

A flash-release throat moistening composition, characterized in that it comprises the following raw materials: Chinese medicinal ingredients, polysaccharide alcohol and starch; The Chinese medicinal ingredients include liquorice, ginseng, bitter almonds, and platycodon; The mass ratio of the starch to the polyol is 1:0.5-1.6. The flash-release throat moistening composition according to claim 1, characterized in that the polysaccharide alcohol is at least one of erythritol, xylitol and sorbitol; and the starch is at least one of potato starch and corn starch. The flash-release throat moistening composition according to claim 1, characterized in that the traditional Chinese medicine ingredient is traditional Chinese medicine powder or traditional Chinese medicine extract. The flash-release throat moistening composition according to claim 1 is characterized in that the mass ratio of licorice, ginseng, bitter almond and platycodon in the traditional Chinese medicine ingredients is 1-4: 0.01-0.5: 0.01-0.5: 0.01-0.25. The flash-release throat moistening composition according to claim 1 is characterized in that it comprises the following raw materials, measured by weight: 2.25-5.25 parts of traditional Chinese medicine ingredients, 40-55 parts of polysaccharide alcohols, and 40-60 parts of starch. The flash-release throat moistening composition according to claim 1, characterized in that it also comprises the following raw materials: sweetener, menthol, and citric acid. The flash-release throat soothing composition according to claim 1 is characterized in that it comprises the following raw materials, measured by weight: 3.5-6.5 parts of sweetener, 1.5-2.5 parts of menthol, and 1-1.25 parts of citric acid. The flash-release throat soothing composition according to claim 1, characterized in that the sweetener is at least one of mogroside, sucralose, stevioside, sucrose and mannitol. The method for preparing the flash-release throat moistening composition according to any one of claims 1 to 8, characterized in that it comprises the following steps: S1. Weigh polyols and starch according to the formula, mix, granulate, granulate, and dry to obtain polyol-starch mixed pregranules; S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, anhydrous citric acid according to the formula amount, mix them with the sugar alcohol-starch mixed pre-granulation in step S1, granulate, granulate, and dry to obtain a flash-release throat moistening composition. The preparation method according to claim 9, characterized in that the granulation in steps S1 and S2 is wet granulation. The preparation method according to claim 10, characterized in that In the wet granulation of step S1, the stirring speed is 100-300 rpm, the cutting speed is 1000-2500 rpm, the water addition amount is 5wt%-7.5wt%, the water inlet rate is 200-400rpm, and the temperature is 20-25°C; In step S2, the wet granulation is performed at a stirring speed of 100-300 rpm, a cutting speed of 1000-2500 rpm, a water addition amount of 5 wt%-12.5 wt%, a water inlet rate of 200-400 rpm, and a temperature of 20-25° C.; The drying in step S1 is: drying at 40-50°C for 0.5-1.5h; The drying in step S2 is as follows: drying at 40-50°C for 0.5-2.5h, and then drying at 80-90°C for 0.5-1h. Use of the flash-release throat moisturizing composition described in any one of claims 1 to 8 or the flash-release throat moisturizing composition prepared by the preparation method described in any one of claims 9 to 11 in the preparation of foods, health products, and medicines for relieving throat discomfort. A flash-release product for relieving throat discomfort, characterized in that it comprises the flash-release throat moisturizing composition described in any one of claims 1 to 8 or the flash-release throat moisturizing composition prepared by the preparation method described in any one of claims 9 to 11. The product according to claim 13 is characterized in that the dosage form of the product is granules, microcapsules, pills, powders or tablets.