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WO2025115637A1 - Produit cosmétique - Google Patents

Produit cosmétique Download PDF

Info

Publication number
WO2025115637A1
WO2025115637A1 PCT/JP2024/040543 JP2024040543W WO2025115637A1 WO 2025115637 A1 WO2025115637 A1 WO 2025115637A1 JP 2024040543 W JP2024040543 W JP 2024040543W WO 2025115637 A1 WO2025115637 A1 WO 2025115637A1
Authority
WO
WIPO (PCT)
Prior art keywords
cosmetic
salt
present
component
oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/JP2024/040543
Other languages
English (en)
Japanese (ja)
Inventor
健太 ▲崎▼山
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shiseido Co Ltd
Original Assignee
Shiseido Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiseido Co Ltd filed Critical Shiseido Co Ltd
Publication of WO2025115637A1 publication Critical patent/WO2025115637A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Definitions

  • the present invention relates to a cosmetic preparation. Specifically, the present invention relates to a cosmetic preparation comprising a pyrimidylpyrazole compound or a salt thereof.
  • Pigmentation such as skin spots and freckles occurs when hormonal abnormalities or exposure to ultraviolet light trigger increased melanin production in epidermal pigment cells, resulting in excessive deposition of melanin in the epidermis.
  • Whitening agents are blended into cosmetics to prevent or improve this abnormal deposition of melanin pigment.
  • whitening agents There are various known ingredients that are blended as whitening agents, and in recent years pyrimidylpyrazole compounds have also been known as useful whitening agents (e.g., Patent Document 1).
  • Oil-in-water emulsion cosmetics are widely used as a base for skin external preparations, including skin cosmetics, due to their fresh feel when used.
  • emulsions are inherently unstable, and are known to cause creaming, aggregation, or coalescence when left for long periods of time.
  • carboxyvinyl polymers which are common water-soluble thickeners.
  • blending a large amount of water-soluble thickener makes it difficult to eliminate sliminess, heavy spread, stickiness, and creasing when applied. Therefore, a combination of polyoxyethylene fatty acid sorbitan, a specific surfactant, and higher alcohol has been proposed to create a cosmetic that is fresh and penetrates without a slimy feel (for example, Patent Document 2).
  • the inventors have surprisingly found that an excellent feeling of use can be achieved by using a cosmetic composition containing a combination of a pyrimidylpyrazole compound or a salt thereof, an N-acylmethyltaurine salt, and a linear higher alcohol.
  • the present invention is based on these findings.
  • a cosmetic preparation comprising (A) an N-acylmethyltaurine salt, (B) a linear higher alcohol, (C) a pyrimidylpyrazole compound represented by formula (1) or a salt thereof, (D) an oil, and (E) water.
  • R 1 , R 3 , R 4 and R 6 are each independently a C 1-3 alkyl group; and R 2 and R 5 are each independently a hydrogen atom or a C 1-3 alkyl group.
  • R 2 and R 5 are each independently a hydrogen atom or a C 1-3 alkyl group.
  • the present invention can provide a cosmetic product that has an excellent feel when used. In particular, it can give the impression of good spreadability during application and can provide a moist feeling to the skin after application.
  • the present invention relates to a cosmetic composition
  • a cosmetic composition comprising (A) an N-acylmethyltaurine salt, (B) a linear higher alcohol, (C) a pyrimidylpyrazole compound having a specific structure or a salt thereof, (D) an oil, and (E) water.
  • the cosmetic preparation according to the present invention comprises (A) an N-acylmethyltaurine salt.
  • the component (A) may be an N-acyltaurine salt having an acyl group having 14 to 22 carbon atoms. Specific examples include N-stearoylmethyltaurine salt, N-palmitoylmethyltaurine salt, and N-myristylmethyltaurine salt, with N-stearoylmethyltaurine salt being preferred.
  • Preferred counter ions include sodium, potassium, triethanolamine, and the like.
  • the component (A) is preferably sodium N-stearoylmethyltaurine.
  • the (A) component may be blended in one or more types.
  • the blended amount of the (A) component is preferably 0.01 to 3 mass %, more preferably 0.05 to 2 mass %, and even more preferably 0.3 to 1.5 mass %, based on the total amount of the cosmetic.
  • the cosmetic preparation according to the present invention comprises (B) a straight-chain higher alcohol.
  • Component (B) is preferably a higher alcohol having 14 to 22 carbon atoms and a straight-chain saturated alkyl group. Examples of component (B) include myristyl alcohol, cetyl alcohol, stearyl alcohol, and behenyl alcohol.
  • Component (B) is preferably cetyl alcohol, stearyl alcohol, or behenyl alcohol.
  • the (B) component may be blended in one or more types.
  • the blended amount of the (B) component is preferably 0.1 to 10 mass % relative to the total amount of the cosmetic, more preferably 0.5 to 8 mass %, and even more preferably 1 to 5 mass %.
  • the cosmetic preparation according to the present invention comprises (C) a pyrimidylpyrazole compound represented by formula (1) or a salt thereof.
  • R 1 , R 3 , R 4 and R 6 are each independently a C 1-3 alkyl group, specifically a methyl group, an ethyl group, an n-propyl group, an isopropyl group, or a cyclopropyl group, preferably a methyl group or an ethyl group, more preferably a methyl group.
  • R 2 and R 5 are each independently a hydrogen atom or a C 1-3 alkyl group, specifically a hydrogen atom, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, or a cyclopropyl group, preferably a hydrogen atom, a methyl group or an ethyl group, more preferably a hydrogen atom.
  • the component (C) may be a salt of the pyrimidylpyrazole compound represented by formula (1).
  • the type of salt is not particularly limited as long as it is a pharma- ceutically acceptable salt, and may be an inorganic salt or an organic salt.
  • Examples of salts include hydrochloride, hydrobromide, sulfate, phosphate, acetate, propionate, citrate, lactate, oxalate, maleate, fumarate, tartrate, and methanesulfonate.
  • the component (C) is preferably dimethylpyrazolyldimethylpyrimidine hydrochloride.
  • the (C) component may be blended in one or more types.
  • the blended amount of the (C) component is preferably 0.1 to 1.5 mass % relative to the total amount of the cosmetic, more preferably 0.3 to 1.3 mass %, and even more preferably 0.4 to 1.2 mass %.
  • (D) Oil The cosmetic composition according to the present invention comprises (D) oil.
  • (D) oil include silicone oil, hydrocarbon oil, ester oil, etc., and ester oil is preferred.
  • (D) does not include (B) component.
  • silicone oils include linear polysiloxanes (e.g., dimethicone, diphenylsiloxyphenyltrimethicone, diphenylpolysiloxane, etc.), cyclic polysiloxanes (e.g., octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, etc.), silicone resins that form a three-dimensional network structure, silicone rubber, various modified polysiloxanes (amino-modified polysiloxanes, polyether-modified polysiloxanes, alkyl-modified polysiloxanes, fluorine-modified polysiloxanes, etc.), acrylic silicones, etc., with linear polysiloxanes being preferred.
  • linear polysiloxanes e.g., dimethicone, diphenylsiloxyphenyltrimethicone, diphenylpol
  • hydrocarbon oils examples include isododecane, isohexadecane, isoparaffin, mineral oil (liquid paraffin), ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, and hydrogenated polydecene.
  • Ester oils include, for example, octyl octanoate, nonyl nonanoate, cetyl octanoate, isopropyl myristate (isopropyl myristate), octyldodecyl myristate, isopropyl palmitate, ethylhexyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate.
  • the (D) component may be blended in one or more types.
  • the blended amount of the (D) component is preferably 10 to 40 mass% and more preferably 15 to 30 mass% based on the total amount of the cosmetic.
  • the cosmetic preparation according to the present invention comprises water (E).
  • water water used in cosmetics, quasi-drugs, etc., can be used, such as purified water, ion-exchanged water, tap water, etc.
  • the blending amount of water is preferably 40 to 90% by mass, more preferably 50 to 80% by mass, based on the total amount of the cosmetic composition according to the present invention.
  • the cosmetic of the present invention can contain optional components that are normally used in cosmetics and pharmaceuticals.
  • Optional components include, for example, moisturizers, lower alcohols, sequestering agents, neutralizing agents, pH adjusters, antioxidants, preservatives, medicines, UV absorbers, powder components, fragrances, etc., and one or more of these can be contained as long as the effects of the present invention are achieved.
  • the formulation of the cosmetic product according to the present invention is not particularly limited, but it is preferable that the cosmetic product be in the form of an oil-in-water emulsion cosmetic. Since the external phase that first comes into contact with the skin is the aqueous phase, the oil-in-water emulsion cosmetic product gives the skin a fresh feeling, making it possible to more effectively experience the effects of the present invention.
  • Cosmetics according to the present invention include, for example, skin care cosmetics (e.g., lotion, milky lotion, cream, serum, pack, mask, etc.), makeup cosmetics (e.g., foundation, makeup base, etc.), skin cleansing agents (e.g., face wash, makeup remover, etc.), sunscreen cosmetics, ointments, etc.
  • the cosmetic according to the present invention is a cream, which allows the effects of the present invention to be more clearly felt. Note that these forms are merely examples, and the cosmetic according to the present invention is not limited to these forms.
  • the viscosity of the cosmetic material used in the present invention is preferably 6,000 mPa ⁇ s or more, and more preferably 6,000 to 14,000 mPa ⁇ s.
  • the cosmetic preparation of the present invention is not particularly limited in the emulsification method, and can be produced according to a conventional method.
  • Example 1 and 2 and Comparative Example 1 According to the formulations shown in Table 1, oil-in-water emulsion cosmetics of Examples 1 and 2 and Comparative Example 1 were prepared.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne un produit cosmétique qui offre une excellente sensation à l'utilisation. Le produit cosmétique selon la présente invention comprend (A) un sel de N-acylméthyltaurine, (B) un alcool linéaire supérieur, (C) un composé pyrimidylpyrazole représenté par la formule (1) ou un sel de celui-ci, (D) un constituant huileux et (E) de l'eau.
PCT/JP2024/040543 2023-11-28 2024-11-15 Produit cosmétique Pending WO2025115637A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2023-201054 2023-11-28
JP2023201054 2023-11-28

Publications (1)

Publication Number Publication Date
WO2025115637A1 true WO2025115637A1 (fr) 2025-06-05

Family

ID=95897769

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2024/040543 Pending WO2025115637A1 (fr) 2023-11-28 2024-11-15 Produit cosmétique

Country Status (1)

Country Link
WO (1) WO2025115637A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009099192A1 (fr) * 2008-02-08 2009-08-13 Shiseido Company Ltd. Agent blanchissant pour la peau et préparation externe pour la peau
JP2010006716A (ja) * 2008-06-24 2010-01-14 Fancl Corp αゲルを含む組成物
WO2012124436A1 (fr) * 2011-03-17 2012-09-20 株式会社 資生堂 Produit cosmétique pour la peau

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009099192A1 (fr) * 2008-02-08 2009-08-13 Shiseido Company Ltd. Agent blanchissant pour la peau et préparation externe pour la peau
JP2010006716A (ja) * 2008-06-24 2010-01-14 Fancl Corp αゲルを含む組成物
WO2012124436A1 (fr) * 2011-03-17 2012-09-20 株式会社 資生堂 Produit cosmétique pour la peau

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