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WO2025113849A1 - Dispositif pour fixer un capteur de pression à un récipient - Google Patents

Dispositif pour fixer un capteur de pression à un récipient Download PDF

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Publication number
WO2025113849A1
WO2025113849A1 PCT/EP2024/077477 EP2024077477W WO2025113849A1 WO 2025113849 A1 WO2025113849 A1 WO 2025113849A1 EP 2024077477 W EP2024077477 W EP 2024077477W WO 2025113849 A1 WO2025113849 A1 WO 2025113849A1
Authority
WO
WIPO (PCT)
Prior art keywords
pressure
pressure sensor
nozzle
sensitive measuring
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/077477
Other languages
German (de)
English (en)
Inventor
Fabian BALTRUSCHAT
Hartmut Damm
Steven RÖSINGER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Endress and Hauser SE and Co KG
Original Assignee
Endress and Hauser SE and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endress and Hauser SE and Co KG filed Critical Endress and Hauser SE and Co KG
Publication of WO2025113849A1 publication Critical patent/WO2025113849A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L19/00—Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
    • G01L19/14—Housings
    • G01L19/147—Details about the mounting of the sensor to support or covering means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L19/00—Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
    • G01L19/0007—Fluidic connecting means
    • G01L19/003—Fluidic connecting means using a detachable interface or adapter between the process medium and the pressure gauge
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L19/00—Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
    • G01L19/06—Means for preventing overload or deleterious influence of the measured medium on the measuring device or vice versa
    • G01L19/0627—Protection against aggressive medium in general
    • G01L19/0645—Protection against aggressive medium in general using isolation membranes, specially adapted for protection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L23/00—Devices or apparatus for measuring or indicating or recording rapid changes, such as oscillations, in the pressure of steam, gas, or liquid; Indicators for determining work or energy of steam, internal-combustion, or other fluid-pressure engines from the condition of the working fluid
    • G01L23/26—Details or accessories

Definitions

  • the invention relates to a device, in particular a disposable device or a disposable adapter, for attaching a pressure sensor to a container or a receptacle.
  • a device in particular a disposable device or a disposable adapter, for attaching a pressure sensor to a container or a receptacle.
  • the pressure sensor is reusable, while the container is preferably a disposable container.
  • Flexible containers such as bags, tubes, or fermenters, are used as containers or bioreactors.
  • the disposable containers are equipped with supply and discharge lines designed as flexible tubes; alternatively, inflexible pipe sections are also used in the supply and discharge lines.
  • invasive sensors To monitor the processes taking place in disposable containers, a wide variety of physical and/or chemical process variables of the media used are recorded. State-of-the-art sensors are preferably used. Sensors used in single-use technology can be roughly divided into two classes: invasive sensors and non-invasive sensors. While an invasive sensor is positioned in the disposable container and at least the measuring element comes into direct contact with the medium to be measured, A non-invasive sensor – isolated from the medium – is connected to the outside of the disposable container.
  • invasive sensors With invasive sensors, coupling to the medium is usually easier than with non-invasive sensors. However, invasive sensors must be disposed of or radioactively sterilized after use. Since radioactive sterilization typically erases the sensor memory or even damages the electronics, at least the software must be reloaded. With non-invasive sensors, sterilization is unnecessary; they can therefore be used iteratively for multiple processes running in disposable containers without great effort.
  • a challenge with non-invasive sensors is attaching the sensor to the disposable container.
  • These disposable containers are typically made of a flexible plastic with low mechanical dimensional stability. Therefore, detachably attaching a compact sensor to a flexible disposable container that is intended to provide reproducible measurement results is not easily feasible.
  • a solution disclosed in US 10,836,990 B2 couples a reusable pressure sensor to a single-use container or a disposable bioreactor via an interface.
  • the interface has a dimensionally stable polymer flange that can be connected to a wall of the disposable container.
  • the polymer flange consists of a side wall and an interface designed to accommodate a separate, deflectable, polymer membrane.
  • a region is provided that is sealingly coupled to the polymer flange. The region is designed to allow the coupling of a reusable measuring device.
  • the interface for coupling a measuring device to a bioreactor which is proposed in the US patent, consists of a large number of individual components and is therefore quite complex.
  • the present invention is based on the object of proposing a simple device for connecting a non-invasive pressure sensor to a disposable container. Furthermore, the invention is based on the object of proposing a simple method for manufacturing a device according to the invention.
  • a device for attaching a pressure sensor to a container, wherein the pressure sensor is provided in a first end region with a pressure-sensitive measuring membrane, via which the pressure of the medium in the container can be determined.
  • a tubular component is provided which can be coupled to the container.
  • the tubular component has a nozzle, on the inner surface of which a radial stop edge is provided.
  • a flexible membrane is attached to the radial stop edge, which seals the nozzle in a gas-tight manner.
  • the holder and the nozzle can be connected to one another via a corresponding fastening mechanism, wherein the connection is preferably designed to be detachable.
  • the nozzle and the holder are further configured such that the pressure-sensitive measuring membrane of the pressure sensor is arranged in the immediate vicinity of the flexible membrane when mounted.
  • the pressure-sensitive measuring diaphragm is preferably a ceramic measuring diaphragm. Sensors with a ceramic measuring diaphragm are developed, offered, and distributed by the Endress+Hauser Group in a wide variety of designs.
  • the pressure sensor is designed to be reusable and removed from the container after the process has been completed via a detachable fastening mechanism. Since the sensor is isolated from the process taking place in the container during measurement/monitoring, subsequent radioactive Sterilization, which would have the aforementioned disadvantage of erasing the memory or destroying the electronics, is no longer necessary.
  • An advantageous embodiment of the device according to the invention provides an annular lip seal which, in the assembled state, is placed between the outer surface of the first end region of the pressure sensor and the corresponding inner surface of the nozzle.
  • the lip seal is designed to equalize pressure in the event of excess pressure between the pressure-sensitive measuring diaphragm and the annular lip seal. This regularly occurs during assembly when the cup-shaped holder with the pressure sensor is attached to the nozzle. If the excess air cannot escape, excess pressure builds up between the flexible diaphragm and the measuring diaphragm, distorting the actual pressure in the process. Due to the use of an annular lip seal, excess air can escape automatically in the inventive solution, so that no undesirable excess pressure is detected at the measuring diaphragm. This is extremely important because pressure at the measuring diaphragm that does not originate from the process would inevitably lead to a measurement error.
  • the annular lip seal is designed to prevent pressure equalization in the event of a negative pressure prevailing between the pressure-sensitive measuring diaphragm and the annular lip seal.
  • a negative pressure prevailing between the pressure-sensitive measuring diaphragm and the annular lip seal.
  • the annular lip seal has a bend in its edge region that is directed away from the pressure-sensitive measuring element.
  • the bend of the annular lip seal tapers towards the outer
  • the gap formed between the edge of the annular lip seal and the inner surface of the nozzle allows excess air to escape easily in the event of overpressure, while in the event of negative pressure, the intake of air from the outside is prevented because the outer edge of the lip seal fits tightly against the corresponding inner surface of the nozzle.
  • the nozzle and the holder are designed such that the pressure-sensitive measuring diaphragm of the pressure sensor, in the mounted state, contacts the flexible diaphragm essentially without force transmission.
  • the nozzle and the holder are designed such that the pressure-sensitive measuring diaphragm of the pressure sensor, in the mounted state, has a maximum distance of 1 mm from the pressure-sensitive measuring diaphragm.
  • the flexible diaphragm is preferably designed such that the measurement error resulting from the fact that the pressure of the medium can only be correctly measured by the pressure sensor when the flexible diaphragm is in contact with the pressure-sensitive measuring diaphragm, lies within the range of the measurement error of the pressure measuring device.
  • the holder and the nozzle be connected to one another via corresponding fastening elements on the cup-shaped holder and the nozzle.
  • the fastening elements can be, for example, a circumferential locking groove and a corresponding locking lug.
  • a screw cap offers another possibility.
  • Other connection options are known to a technically qualified person.
  • the attachment of the cup-shaped holder to the nozzle is designed so that it can be carried out with one hand.
  • the tubular component has connecting elements in both of its end areas for connection to, for example, hoses of the container.
  • the container is preferably a disposable container that can be disposed of after the process has been completed. is disposed of appropriately. This eliminates the need for a potentially complex cleaning and sterilization process.
  • An embodiment of the device according to the invention provides that the components of the device are preferably made of a biocompatible material, for example polyethylene.
  • the object underlying the invention is achieved by a method for manufacturing a device as described above in various embodiments.
  • the following method steps are proposed:
  • the modified tubular component is sealed in a bag and sterilized using radioactive radiation.
  • the flexible membrane is attached to the radial stop edge or on the radial stop edge using a welding or gluing process.
  • Fig. 1 a longitudinal section through an embodiment of the device according to the invention
  • Fig. 2 a perspective view of an embodiment of the lip seal which can be used in connection with the device according to the invention.
  • Fig. 3 a cross-section through the lip seal according to the marking III-III in Fig. 2.
  • Fig. 1 shows a longitudinal section through an embodiment of the disposable device 1 according to the invention for coupling the pressure sensor 2 on the container 20.
  • the pressure sensor 2 is preferably a ceramic pressure sensor 2 which is pressure-tightly sealed in a first end region 2a with a pressure-sensitive measuring membrane 3.
  • Ceramic materials used for the production of a pressure-sensitive material used for the production of a pressure-sensitive material
  • the pressure sensor 2 determines the pressure of the medium 21 located in the container 20.
  • the container 20 is shown schematically in Fig. 1.
  • the supply and discharge lines for coupling the container 20 to the device 1 according to the invention are not shown in Fig. 1.
  • the device 1 comprises a tubular component 4 with fastening elements 6a, 6b in the edge regions.
  • the tubular component 4 is connected to the container 20 via the fastening elements 6a, 6b and corresponding fastening elements (not shown separately in Fig. 1) on the supply and discharge lines of the container 21.
  • the tubular component 4 has a nozzle 5, on whose inner surface 7 a radial stop edge 9 is provided.
  • the stop edge 9 is created, for example, by appropriate milling or casting of the nozzle 5.
  • a flexible membrane 10 is attached to—or in the case shown, onto—the radial stop edge 9, which seals the nozzle 5 in a gas-tight manner.
  • a cup-shaped holder 11 is provided, in which a second end region 2b of the pressure sensor 2, facing away from the pressure-sensitive measuring membrane 3, can be placed.
  • the cup-shaped holder 11 and the nozzle 5 can be connected to one another via a corresponding fastening mechanism 12a, 12b.
  • the fastening mechanism 12a, 12b is a circumferential locking lug 12b on the inner surface 18 of the lower edge region of the cup-shaped holder 11, which, when mounted, engages in a corresponding locking groove 12a on the outer surface 8 of the nozzle 5.
  • the connection can also be established, for example, via a screw connection. the connection of the two components 11, 5 is designed so that it can be carried out with one hand.
  • the nozzle 5 and the cup-shaped holder 11 are designed such that the pressure-sensitive measuring membrane 3 of the pressure sensor 2 is arranged in the immediate vicinity of the flexible membrane 10 in the mounted state.
  • "immediately” preferably means that the flexible membrane 10 touches the pressure-sensitive measuring membrane 3 of the pressure sensor 2 in the mounted state without prestress, or that it is spaced from it by a maximum of 1 mm.
  • annular lip seal 13 is provided, which, in the assembled state, is placed between the outer surface 17 of the first end region 2a of the pressure sensor 2 and the corresponding inner surface 7 of the nozzle 5.
  • the annular lip seal 13 is designed such that, in the event of an overpressure prevailing between the pressure-sensitive measuring diaphragm 3, the flexible diaphragm 10, and the annular lip seal 13, it creates pressure equalization by allowing excess air to escape through a gap between the lip seal 13, which is bent upwards in the edge region 15, and the inner surface 7 of the nozzle 5.
  • the annular lip seal 13 behaves differently when a negative pressure occurs: If a negative pressure occurs in the space between the pressure-sensitive measuring diaphragm 3, the flexible diaphragm 10, and the annular lip seal 13, the edge area or the upturn 15 of the lip seal 13 clings to the inner surface 7 of the nozzle 5, effectively preventing pressure equalization. Therefore, when a negative pressure occurs, no air is sucked from outside into the space delimited by the flexible diaphragm 10 and the lip seal 13. The upturn 15 and the taper 16 of the lip seal in the outer edge area are clearly visible in Fig. 2.
  • Fig. 3 shows a cross section through the lip seal 13 according to the marking III-III in Fig. 2.

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Combustion & Propulsion (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Fluid Pressure (AREA)

Abstract

L'invention concerne un dispositif à usage unique (1) pour fixer un capteur de pression (2) à un récipient (20). Une première région d'extrémité (2a) du capteur de pression (2) est pourvue d'un diaphragme de mesure sensible à la pression (3), par l'intermédiaire duquel la pression du milieu (21) situé dans le récipient (20) peut être déterminée, un composant tubulaire (4) étant prévu qui peut être accouplé au récipient (20), et le composant tubulaire (4) présentant une pièce de liaison (5), dont la surface interne (7) est pourvue d'un bord d'arrêt radial (9). Une membrane souple (10) qui ferme la pièce de liaison (5) de manière étanche aux gaz est installée sur le bord d'arrêt radial (9), et est prévu un support en forme de coupelle (11) dans lequel une seconde région d'extrémité (2b) du capteur de pression (2) peut être placée, ladite seconde région d'extrémité étant opposée à la membrane de mesure sensible à la pression (3). Le support en forme de coupelle (11) et la pièce de liaison (5) peuvent être verrouillés par l'intermédiaire d'un mécanisme de fixation correspondant (12), et la pièce de liaison (5) et le support en forme de coupelle (11) sont conçus de telle sorte que, à l'état installé, le diaphragme de mesure sensible à la pression (3) du capteur de pression (2) est à proximité directe du diaphragme flexible (10).
PCT/EP2024/077477 2023-11-30 2024-09-30 Dispositif pour fixer un capteur de pression à un récipient Pending WO2025113849A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102023133478.6A DE102023133478A1 (de) 2023-11-30 2023-11-30 Vorrichtung zur Befestigung eines Drucksensors an einem Behältnis
DE102023133478.6 2023-11-30

Publications (1)

Publication Number Publication Date
WO2025113849A1 true WO2025113849A1 (fr) 2025-06-05

Family

ID=92966530

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2024/077477 Pending WO2025113849A1 (fr) 2023-11-30 2024-09-30 Dispositif pour fixer un capteur de pression à un récipient

Country Status (2)

Country Link
DE (1) DE102023133478A1 (fr)
WO (1) WO2025113849A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0208955A2 (fr) * 1985-07-17 1987-01-21 Peter von Berg, Extrakorporale Systeme -Medizintechnik GmbH Procédé pour réaliser un contact de transmission de pression entre la membrane d'une capsule de pression et le transmetteur de pression d'un capteur de mesure et dispositif de mesure de pression pour déterminer la pression physiologique des fluides d'un corps humain ou animal
US4798089A (en) * 1987-03-12 1989-01-17 Rosemount Inc. Isolator apparatus
US6820490B2 (en) * 2001-10-16 2004-11-23 Neomedix Corporation Systems and methods for measuring pressure
US20190392280A1 (en) * 2018-06-21 2019-12-26 Rosemount Inc. Single-use pressure transducer disposable interface
US10836990B2 (en) 2016-12-23 2020-11-17 Cyberoptics Corporation Sensor interface for single-use containers
DE102019125272A1 (de) * 2019-09-19 2021-03-25 LABOM Meß- und Regeltechnik Gesellschaft mit beschränkter Haftung Druckmess-Einwegartikel sowie Druckmesssystem mit derartigem Druckmess-Einwegartikel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2943134B1 (fr) * 2009-03-13 2011-10-07 Millipore Corp Dispositif pour determiner une grandeur physique d'un liquide circulant dans une conduite

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0208955A2 (fr) * 1985-07-17 1987-01-21 Peter von Berg, Extrakorporale Systeme -Medizintechnik GmbH Procédé pour réaliser un contact de transmission de pression entre la membrane d'une capsule de pression et le transmetteur de pression d'un capteur de mesure et dispositif de mesure de pression pour déterminer la pression physiologique des fluides d'un corps humain ou animal
US4798089A (en) * 1987-03-12 1989-01-17 Rosemount Inc. Isolator apparatus
US6820490B2 (en) * 2001-10-16 2004-11-23 Neomedix Corporation Systems and methods for measuring pressure
US10836990B2 (en) 2016-12-23 2020-11-17 Cyberoptics Corporation Sensor interface for single-use containers
US20190392280A1 (en) * 2018-06-21 2019-12-26 Rosemount Inc. Single-use pressure transducer disposable interface
DE102019125272A1 (de) * 2019-09-19 2021-03-25 LABOM Meß- und Regeltechnik Gesellschaft mit beschränkter Haftung Druckmess-Einwegartikel sowie Druckmesssystem mit derartigem Druckmess-Einwegartikel

Also Published As

Publication number Publication date
DE102023133478A1 (de) 2025-06-05

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