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WO2025112964A1 - Composition d'élimination et de réparation de l'acné contenant du collagène recombinant et utilisation correspondante - Google Patents

Composition d'élimination et de réparation de l'acné contenant du collagène recombinant et utilisation correspondante Download PDF

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Publication number
WO2025112964A1
WO2025112964A1 PCT/CN2024/125646 CN2024125646W WO2025112964A1 WO 2025112964 A1 WO2025112964 A1 WO 2025112964A1 CN 2024125646 W CN2024125646 W CN 2024125646W WO 2025112964 A1 WO2025112964 A1 WO 2025112964A1
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Prior art keywords
acne
repairing
recombinant collagen
gel
parts
Prior art date
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Application number
PCT/CN2024/125646
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English (en)
Chinese (zh)
Inventor
郭朝万
孙怀庆
王宁
王娟
裴运林
蒲艳
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Guangdong Marubi Biological Technology Co Ltd
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Guangdong Marubi Biological Technology Co Ltd
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Publication of WO2025112964A1 publication Critical patent/WO2025112964A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the present application belongs to the technical field of acne-removing products, and relates to an acne-removing and repairing composition containing recombinant collagen and its application.
  • Acne also known as pimples, blackheads, and pimples, is a common and frequent skin disease.
  • the root cause of its formation is a chronic skin disease that occurs in the sebaceous glands of the hair follicles. Due to the strong secretion of oil, the pores are blocked. It often occurs in the head, face, neck and other parts rich in sebaceous glands, affecting the beauty effect.
  • CN107737033A discloses a composition for quickly removing acne and acne marks and its preparation method.
  • the raw materials include the following components: 1.2-1.8 parts of salicylic acid, 2-2.77 parts of arginine, 0.5-2 parts of Usnea barbata extract, 1-10 parts of glabridin liposomes, 0.03-0.1 parts of O-cymene-5-ol, 1-12 parts of other acne-removing ingredients, and 75-90 parts of other base materials.
  • This product combines a specific amount of salicylic acid with arginine, compounding a specific amount of Usnea barbata extract and glabridin liposomes, and supplementing with O-cymene-5-ol as a mild and effective preservative.
  • the product prepared by adding other anti-acne ingredients has good anti-acne effect.
  • the raw material contains salicylic acid, which can irritate the skin and mucous membranes, may damage the skin barrier, and may cause allergic symptoms. It is not suitable for people with sensitive skin.
  • Azelaic acid has antibacterial and anti-inflammatory effects, regulates hair follicle keratinization, inhibits oil secretion, reduces pigmentation, and inhibits cell proliferation; nisin can interact with anionic lipids on bacterial cell membranes to cause disturbances in the cell membrane and achieve the effect of inhibiting bacteria; acetylcysteine can be used as a skin conditioner, antioxidant or protease inhibitor in cosmetics and skin care products; recombinant collagen is collagen prepared using DNA recombinant technology. Collagen can supplement the amino acids needed by the skin, repair damaged skin, and provide the skin with essential nutrients.
  • the acne-repairing composition comprises, by weight, 4-10 parts of azelaic acid, 0.1-1 parts of nisin, 0.5-5 parts of acetylcysteine, and 0.01-1 parts of recombinant collagen.
  • the present application provides the use of the acne-removing and repairing composition containing recombinant collagen according to the first aspect in the preparation of an acne-removing and repairing product.
  • the amount of the acne-repairing composition added to the acne-repairing product is 1-20%, for example, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 14%, 15%, 20%, etc., other specific point values within this numerical range can be selected, and will not be described here one by one.
  • the product comprises a cosmetic or a pharmaceutical.
  • the present application provides a gel with acne-removing and repairing effects, wherein the raw materials for preparing the gel include, by mass percentage: 1-20% of the acne-removing and repairing composition described in the first aspect, 0.5-5% of the gel, 0.2-2% of the solubilizer, 5-20% of the polyol, 0.1-1% of triethanolamine and 50-90% of water.
  • the mass percentage of the acne-removing and repairing composition can be selected as 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 14%, 15%, 20%, etc.; the mass percentage of the gel can be selected as 0.5%, 0.6%, 0.8%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, 2%, 3%, 4%, 5%, etc.; the mass percentage of the solubilizing agent can be selected as 0.2%, 0.3%, 0.5%, 0.6%, 0.8%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, 2%, 3%, 4%, 5%, etc.
  • the mass percentage of the polyol can be selected as 5%, 6%, 7%, 8%, 9%, 10%, 12%, 14%, 15%, 20%, etc.; the mass percentage of the triethanolamine can be selected as 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.7%, 0.8%, 0.9%, 1%, etc.; the mass percentage of water can be selected as 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, etc.; other specific point values within the above numerical range can be selected, which will not be repeated here.
  • the solubilizing agent includes PPG-26-buteth-26 and/or PEG-40 hydrogenated castor oil.
  • the mass percentage of the plant-based conditioning agent can be selected as 1%, 2%, 3%, 4%, 5%, 6%, 8%, 10% or the like; the mass percentage of the antioxidant can be selected as 0.05%, 0.08%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.4%, 0.5% or the like; the mass percentage of the fragrance can be selected as 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.4%, 0.5% or the like; other specific point values within the above numerical range can be selected, and they will not be described one by one here.
  • the plant-derived conditioning agent includes a safflower flower extract and/or a kapok flower extract.
  • the present application has also creatively discovered that when the above-mentioned product is further added with Sufanghua extract and/or Kapok extract, especially the combination of Sufanghua extract and Kapok extract, the antibacterial, anti-inflammatory and acne-removing effects of the product can be further improved.
  • the Sufanghua extract and Kapok extract also have a synergistic effect in exerting the above-mentioned effects.
  • the present application provides a method for preparing the gel having acne-removing and repairing effects according to the third aspect, the preparation method comprising the following steps:
  • the gel is mixed with part of water at 25-45° C. to obtain solution A; the acne-removing and repairing composition, the solubilizer, the polyol and the remaining water are mixed at 30-50° C. to obtain solution B; solution A and solution B are mixed at 20-40° C., triethanolamine and the remaining preparation raw materials are added to obtain the gel with acne-removing and repairing effect.
  • This application creatively combines four components of azelaic acid, nisin, acetylcysteine and recombinant collagen, wherein azelaic acid, nisin and acetylcysteine have potential mutual promotion effects in inhibiting Propionibacterium acnes and anti-inflammatory, thereby also having a synergistic effect in inhibiting and relieving acne formation and repairing acne; wherein recombinant collagen can repair skin damaged by acne and inflammation, and can provide sufficient nutrients to damaged skin to help the skin repair better, because it can further promote the efficacy of azelaic acid, nisin and acetylcysteine in removing acne, and the four ingredients work together to remove acne and repair from different mechanisms and angles.
  • the composition can well balance excellent acne-removing and repairing efficacy and excellent mildness.
  • the Sufanghua extract involved in the following content comes from the products of Lanzhou Waterless Biotechnology Co., Ltd.; the Kapok flower extract comes from the products of Lanzhou Waterless Biotechnology Co., Ltd.; and the Nisin comes from the products of Guangzhou Tianjia Biotechnology Co., Ltd.
  • the recombinant collagen involved in the following content is the product prepared in the preparation example.
  • the pET-28a(+) vector in the preparation example was purchased from MacLean; the BL21(DE3) chemically competent cells were purchased from Merck with product number CMC0014-4X40UL.
  • This preparation example provides a recombinant collagen freeze-dried powder, and its preparation method refers to ZL
  • the method disclosed in Preparation Example 1 in 202310123476.3 is carried out as follows:
  • Fermentation culture of recombinant fermentation strains 10 ⁇ L of recombinant collagen fermentation broth was spread on a solid LB plate, cultured in a 37°C incubator for 12 h, and then a single clone was selected and inoculated into 50 mL of LB liquid culture medium containing 50 ⁇ g/mL kanamycin. The culture was placed in a shaker at 37°C, 200 rpm for 14 h, and then inoculated into 200 mL of LB liquid culture medium containing 50 ⁇ g/mL kanamycin at a ratio of 1:100.
  • the culture was cultured at 37°C until the OD of the bacterial solution was 0.6, and then IPTG was added to a final concentration of 1 mM. The culture was continued for 4 h, and then the bacteria were collected by centrifugation at 4°C, 4000 rpm for 15 min.
  • the protein concentration was then detected using a BCA kit, and 0.5mL of a 5% volume concentration mannitol aqueous solution was added to every 5mg of protein and mixed with the mannitol aqueous solution.
  • the mixture was then pre-frozen at -40°C for 10min using a freeze dryer and finally freeze-dried at -35°C to obtain a recombinant collagen freeze-dried powder.
  • This embodiment provides an acne-removing and repairing composition, which is composed of the following components by mass: 5 parts of azelaic acid, 1 part of nisin, 3 parts of acetylcysteine and 0.08 parts of recombinant collagen.
  • the components can be physically mixed evenly according to the mass ratio.
  • This embodiment provides an acne-removing and repairing composition, which is composed of the following components by mass: 4 parts of azelaic acid, 0.5 parts of nisin, 5 parts of acetylcysteine and 0.05 parts of recombinant collagen.
  • the components can be physically mixed evenly according to the mass ratio.
  • This application example provides a gel, the formula of which is different from that of application example 4 only in that the extract of Sufanghua is missing, the mass percentage of kapok flower extract is 8%, and the other components and contents remain unchanged.
  • This application example provides a gel, the formula of which is different from that of application example 4 only in that the kapok flower extract is missing, the mass percentage of the kapok flower extract is 8%, and the other components and contents remain unchanged.
  • This application example provides a gel, the formula of which is different from that of application example 1 only in that it lacks the acne-repairing composition, and its reduced mass is supplemented by water, while other components and contents remain unchanged.
  • Sample solutions 1-11 correspond to application examples 1-7 and comparative application examples 1-4, respectively.
  • the difference between their formulas and those of application examples 1-7 and comparative application examples 1-4 is that they do not contain solubilizers, gelling agents, and glycerol, and their reduced mass is supplemented by water.
  • the preparation method is: azelaic acid is mixed with 1,3-propylene glycol and butylene glycol at 30°C, and then mixed with nisin, acetylcysteine, recombinant collagen, and water at 30°C, and a conditioner is optionally added and mixed to obtain the solution.
  • Propionibacterium acnes was inoculated at 1 ⁇ 10 6 /mL in a 96-well plate, 150 ⁇ L per well, and 150 ⁇ L of sample solutions 1-11 were added respectively, and the same volume of culture medium was added as a blank control, and the plates were placed in a 37°C constant temperature incubator and cultured under anaerobic conditions for 48 hours.
  • the absorbance at 600 nm was measured by an ultraviolet spectrophotometer, and the inhibition rate of Propionibacterium acnes (%) was calculated according to the following formula. Each group was measured 5 times in parallel, and the average value was taken.
  • Propionibacterium acnes inhibition rate (%) (blank group absorbance - test group absorbance) / blank group absorbance ⁇ 100%
  • the acne-removing and repairing composition involved in the present application has a significant inhibitory effect on Propionibacterium acnes, and azelaic acid, nisin, and acetylcysteine have a synergistic effect in inhibiting Propionibacterium acnes.
  • the extract of Sufanghua and the extract of Kapok can further enhance the above effects, and the two have a synergistic promoting effect.
  • Sample solutions 1-11 correspond to application examples 1-7 and comparative application examples 1-4, respectively.
  • the difference between their formulas and those of application examples 1-7 and comparative application examples 1-4 is that they do not contain solubilizers, gelling agents, and glycerol, and their reduced mass is supplemented by water.
  • the preparation method is: azelaic acid is mixed with 1,3-propylene glycol and butylene glycol at 30°C, and then mixed with nisin, acetylcysteine, recombinant collagen, and water at 30°C, and a conditioner is optionally added and mixed to obtain the solution.
  • the acne-repairing composition involved in the present application has a significant anti-inflammatory effect, and azelaic acid, nisin, and acetylcysteine have a synergistic effect in inhibiting inflammatory factors.
  • the extract of Sufanghua and the extract of Kapok can further enhance the above effects, and the two have a synergistic promoting effect.
  • a total of 160 female and male volunteers with oily acne skin aged 18-40 were selected and randomly divided into 8 groups, with 20 people in each group, half of them male and half female.
  • Each group used the products of Application Examples 1, 4-6 and Comparative Application Examples 1-4, and used the products once a day after facial cleansing in the morning and evening for 60 consecutive days. During this period, no other acne-removing products were used, and the usage and operation were basically the same.
  • the mildness and acne repair effects of the products were scored and evaluated, with the highest score being 5 points and the lowest score being 1 point, with a score range of 1-5.
  • the evaluation results are shown in Table 4 (average score):
  • the composition involved in the present application and the cosmetics prepared therefrom have both excellent acne-removing and repairing properties and mildness, among which recombinant collagen plays an important role in improving the acne-removing and repairing effect and mildness of the product, and the plant extracts added to the cosmetics can further enhance the acne-removing and repairing effect of the composition, and the Sufanghua extract and the Kapok flower extract have a certain synergistic effect in improving the acne-removing and repairing effect of the product.
  • the present application illustrates the technical solution of the present application through the above-mentioned embodiments, but the present application is not limited to the above-mentioned embodiments, that is, it does not mean that the present application must rely on the above-mentioned embodiments to be implemented.
  • the technicians in the relevant technical field should understand that any improvement to the present application, the equivalent replacement of the raw materials of the product of the present application, the addition of auxiliary components, the selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present application.

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Abstract

La présente demande concerne une composition d'élimination et de réparation de l'acné contenant un collagène recombinant et son utilisation. La composition d'élimination et de réparation de l'acné comprend de l'acide azélaïque, de la nisine, de l'acétylcystéine et du collagène recombinant. La présente demande utilise de manière inventive les quatre constituants en combinaison. L'acide azélaïque, la nisine et l'acétylcystéine ont un effet potentiel de favoriser mutuellement l'inhibition de Cutibacterium acnes et la résistance à l'inflammation, présentant ainsi un effet synergique en termes d'inhibition et de soulagement de la formation de l'acné et de réparation de l'acné. Le collagène recombinant peut réparer la peau endommagée par l'acné et l'inflammation et peut fournir suffisamment d'ingrédients nutritionnels à la peau endommagée pour aider la peau à obtenir une meilleure réparation. Comme le collagène recombinant peut en outre favoriser l'efficacité de l'acide azélaïque, de la nisine et de l'acétylcystéine dans l'élimination de l'acné, les quatre constituants fonctionnent ensemble par l'intermédiaire de différents mécanismes et à partir de différentes perspectives pour obtenir l'effet d'élimination et de réparation de l'acné. De plus, la composition permet de bien équilibrer les excellents effets d'élimination et de réparation de l'acné avec une douceur exceptionnelle.
PCT/CN2024/125646 2023-11-29 2024-10-18 Composition d'élimination et de réparation de l'acné contenant du collagène recombinant et utilisation correspondante Pending WO2025112964A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202311623336.9A CN117481997B (zh) 2023-11-29 2023-11-29 一种含有重组胶原蛋白的祛痘修复组合物及其应用
CN202311623336.9 2023-11-29

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CN117481997B (zh) * 2023-11-29 2024-05-17 广东丸美生物技术股份有限公司 一种含有重组胶原蛋白的祛痘修复组合物及其应用

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KR20030046121A (ko) * 2001-12-05 2003-06-12 주식회사 태평양 니신을 함유하는 여드름 피부용 외용제 조성물
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KR20190021114A (ko) * 2017-08-22 2019-03-05 유한킴벌리 주식회사 식물 추출물을 포함하는 피부 항염, 피지 분비 억제용, 또는 여드름 개선용 조성물
CN114028264A (zh) * 2021-11-26 2022-02-11 广州贝奥吉因生物科技股份有限公司 一种用于祛痘修护的微针贴及其制备方法和应用
CN115252460A (zh) * 2022-08-18 2022-11-01 媞颂日化用品(广州)有限公司 一种含抗菌肽的祛痘组合物及其制备方法和应用
CN117481997A (zh) * 2023-11-29 2024-02-02 广东丸美生物技术股份有限公司 一种含有重组胶原蛋白的祛痘修复组合物及其应用

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