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WO2025110742A1 - Système électroceutique implantable comprenant une électrode corticale et un dispositif de charge sans fil - Google Patents

Système électroceutique implantable comprenant une électrode corticale et un dispositif de charge sans fil Download PDF

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Publication number
WO2025110742A1
WO2025110742A1 PCT/KR2024/018482 KR2024018482W WO2025110742A1 WO 2025110742 A1 WO2025110742 A1 WO 2025110742A1 KR 2024018482 W KR2024018482 W KR 2024018482W WO 2025110742 A1 WO2025110742 A1 WO 2025110742A1
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WO
WIPO (PCT)
Prior art keywords
brain
integrated circuit
transceiver
present
contact portion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/KR2024/018482
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English (en)
Korean (ko)
Inventor
양성구
김병관
이규일
이상원
김민지
김경태
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Gbrain Inc
Original Assignee
Gbrain Inc
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Filing date
Publication date
Application filed by Gbrain Inc filed Critical Gbrain Inc
Priority claimed from KR1020240166975A external-priority patent/KR20250075527A/ko
Publication of WO2025110742A1 publication Critical patent/WO2025110742A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04B—TRANSMISSION
    • H04B13/00—Transmission systems characterised by the medium used for transmission, not provided for in groups H04B3/00 - H04B11/00
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04B—TRANSMISSION
    • H04B5/00—Near-field transmission systems, e.g. inductive or capacitive transmission systems
    • H04B5/70—Near-field transmission systems, e.g. inductive or capacitive transmission systems specially adapted for specific purposes
    • H04B5/72—Near-field transmission systems, e.g. inductive or capacitive transmission systems specially adapted for specific purposes for local intradevice communication
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04B—TRANSMISSION
    • H04B5/00—Near-field transmission systems, e.g. inductive or capacitive transmission systems
    • H04B5/70—Near-field transmission systems, e.g. inductive or capacitive transmission systems specially adapted for specific purposes
    • H04B5/79—Near-field transmission systems, e.g. inductive or capacitive transmission systems specially adapted for specific purposes for data transfer in combination with power transfer

Definitions

  • the present invention relates to an implantable electronic drug system including a brain cortex electrode and a wireless charging device.
  • the present invention was studied with the support of the following tasks.
  • Brain implantable medical devices are devices that contain multiple microelectrodes that acquire neural signals or transmit electrical stimulation, and act as neural interfaces that connect neurons to electronic circuits. Electrical stimulation has the advantages of fewer side effects, reversibility, and ease of adjustment compared to drug therapy or surgery.
  • brain implantable medical devices cause inconvenience to patients when inserted into the brain due to the connection wire to the outside, and there are inconveniences such as having to perform a separate connection procedure to the outside.
  • the present invention has been created to solve the problems of the prior art as described above and to expand the scope of application.
  • the purpose of the present invention is to provide a medical device for measuring brain signals and transmitting stimulation, which can minimize opening of the skull by having a minimum volume using a high-performance element with excellent adhesion to living tissue and a laminated structure design.
  • the present invention comprises an interpolation element including a contact portion for measuring a signal generated in the brain or transmitting a stimulus to the brain, a transceiver portion configured to transmit a signal received from the contact portion to the outside or to transmit a signal instructing the stimulus to the contact portion, and a connection portion connecting between the contact portion and the transceiver portion; and an integrated circuit connected to the transceiver portion for transmitting and receiving a signal, wherein the integrated circuit is characterized by having a laminated structure.
  • the integrated circuit includes a housing; and a laminated portion having the laminated structure, wherein the housing includes an upper case protecting an upper direction of the laminated portion; a side case having a height higher than the height of the laminated portion and having a through portion on at least a portion of one side; and a lower case formed below the laminated portion; wherein the side case may be formed larger than the laminated portion so that at least a portion of space is formed between the side case and the laminated portion.
  • the transceiver may be formed so that at least a portion thereof penetrates the penetration portion.
  • the upper case may be formed of a synthetic resin material
  • the side case and the lower case may be formed of a metal material.
  • the laminated portion may include a receiver coil, a battery, an IC, a PCB, and at least a portion of the transceiver.
  • the transceiver of the laminated portion is formed on the lowest layer, and can be laminated in the order of the transceiver, PCB, IC, battery, and receiver coil.
  • the battery may be formed in a circular shape, and the housing may be provided in a square shape.
  • each component of the laminated portion can be electrically connected.
  • the interpolation element has excellent flexibility and mechanical properties, so that it can be installed in the brain, thereby enabling surgery by opening only a very narrow area of the skull region, thereby increasing the stability of the surgery, and minimizing the volume of the structure including the integrated circuit installed in the skull, thereby minimizing the discomfort of the patient.
  • FIG. 1 is a drawing showing the configuration of an interpolation element according to an embodiment of the present invention.
  • FIG. 2 is a drawing showing a form in which an integrated circuit according to an embodiment of the present invention is attached to a skull surface.
  • FIG. 3 is a diagram briefly showing the internal configuration of an integrated circuit according to an embodiment of the present invention.
  • FIG. 4 is a schematic diagram of a system including a brain cortex electrode and an inductive coupling technology-based wireless device according to another embodiment of the present invention.
  • FIG. 5 is a schematic diagram illustrating an example of an interpolation element according to another embodiment of the present invention.
  • FIG. 6 is a schematic diagram illustrating another example of an interpolation element according to another embodiment of the present invention.
  • FIG. 7 is a schematic diagram illustrating another example of an interpolation element according to another embodiment of the present invention.
  • FIG. 8 is a schematic drawing showing an example of a left end according to another embodiment of the present invention.
  • FIG. 9 is a schematic drawing showing an example of a connecting part according to another embodiment of the present invention.
  • FIG. 10 is a drawing schematically illustrating another example of a connecting portion according to another embodiment of the present invention.
  • FIG. 11 is a drawing schematically illustrating another example of a connecting portion according to another embodiment of the present invention.
  • FIG. 12 is a schematic drawing showing an example of a system including a guide portion according to another embodiment of the present invention.
  • FIG. 13 is a schematic drawing of a guide part including a fixing member according to another embodiment of the present invention.
  • FIG. 14 is a schematic diagram illustrating another example of a system according to another embodiment of the present invention.
  • FIG. 15 is a schematic diagram illustrating another example of a system according to another embodiment of the present invention.
  • FIG. 16 is a schematic diagram of a system including a brain cortex electrode and an inductive coupling technology-based wireless device according to another embodiment of the present invention.
  • FIG. 1 is a drawing showing the configuration of an interpolation element according to an embodiment of the present invention
  • FIG. 2 is a drawing showing a form in which an integrated circuit according to an embodiment of the present invention is attached to a skull surface.
  • a system (10) including a brain cortex electrode and an inductive coupling technology-based wireless device includes an interpolation element (100) and an integrated circuit (200).
  • the system (10) including a brain cortex electrode and an inductive coupling technology-based wireless device may be a structure for measuring and stimulating brain signals, and may be a system including the same.
  • the interpolation element (100) of the embodiment of the present invention with reference to FIG. 1 may include a contact portion (110), a connection portion (120), and a transceiver portion (130).
  • the interpolation element may include a contact portion (110) that contacts the surface of the cerebral cortex, a transceiver portion (130) that is installed in the space between the skull and the skin, and a connection portion (120) that connects the contact portion (110) and the transceiver portion (130) at both ends and is arranged across the inside and outside of the skull by passing through the skull.
  • the interpolation element (100) is a flexible cerebral cortex electrode that can be transformed into various shapes, and embodiments of each shape will be described later.
  • the system (10) including the brain cortex electrode and wireless device of the present invention may include components for a flexible electrode, a wireless link, and wireless power, recording, and stimulation.
  • the contact portion (110) contacts the cerebral cortex, and the connection portion (120) penetrates the skull to connect the contact portion (110) and the transceiver portion (130).
  • the contact portion (110) may include electrode pads, and contacts the cerebral cortex through the electrode pads.
  • the transceiver (130) is coupled to the integrated circuit (200) and is positioned between the skull and the skin or on the skull or inserted into the skull.
  • FIG. 3 is a diagram briefly showing the internal configuration of an integrated circuit (200) according to an embodiment of the present invention.
  • the integrated circuit (200) of the embodiment of the present invention may be a wireless chip, and serves to wirelessly transmit and receive radio waves or wirelessly receive power.
  • the integrated circuit (200) may include a wireless power device, a recording device, a stimulation device, a wireless communication device, and may be a package that includes the above-described components to enhance biocompatibility.
  • the integrated circuit (200) is installed in the space between the skull and the skin.
  • the wireless power device is for supplying power to the integrated circuit (200)
  • the recording device is for recording measured brain waves
  • the stimulation device is for processing signals for providing stimulation to the brain
  • the wireless communication device is a component for wirelessly transmitting the measured brain waves to the outside and receiving external commands.
  • the integrated circuit (200) records radio wave measurements received from the brain to obtain bio-information and detects abnormal signals.
  • the integrated circuit (200) applies energy such as current, voltage, magnetic field, or electric field stimulation to perform neuro-modulation to treat a disease or control brain activity.
  • the integrated circuit (200) may include a wireless chip power supply (210) which is a wireless power device, a recorder (220) which is a recording device, a stimulator (230) which is a stimulating device, a chip controller (240), and a communication device (250).
  • the wireless chip power supply (210) includes a power regulator (211) and a battery (212).
  • the battery (212) can supply energy wirelessly (energy harvesting) using an RF coil, an on-chip coil, etc., and can store energy supplied wirelessly.
  • the battery (212) can be charged wirelessly using WPT (Wireless Power Transfer) technology.
  • WPT Wireless Power Transfer
  • the power regulator (211) is a current converter that converts AC of the battery (212) into DC and transmits it directly to the chip controller (240) or transmits it to a power management circuit (Power Management System; 294; FIG. 15) and then transmits it to the chip controller (240).
  • a power management circuit Power Management System; 294; FIG. 15
  • a Neural Micro Electrode is an electrode (111) attached to the brain that can measure brain waves and perform electrical stimulation.
  • it may be an electrode (111) formed on a contact portion (110) of an interpolation element (100).
  • analog data measured by a Neural Micro Electrode is converted into digital data by a converter (ADC; 291 Fig. 15) and transmitted to a chip controller (240).
  • ADC analog data measured by a Neural Micro Electrode
  • the digital data can be recorded by a recorder (220), and the recorded digital data is wirelessly transmitted to an external device through a wireless communication device (250) via the chip controller (240).
  • the converter (ADC; 291) varies depending on the number of brain wave measurement panels, i.e., the number of electrodes (111), and can be configured to be included in the recorder (220).
  • the recorder (220) can input and convert multi-channel brainwave measurement data into digital signals through a converter (ADC; 291).
  • the chip controller (240) can control measurement signals and stimulus signals.
  • the wireless communication device (250) is wirelessly connected to an external communication network so that it can be monitored from outside the body.
  • the wireless communication device (250) can wirelessly transmit a digital signal converted by a converter (ADC; 291) of the recorder (220) through an electrode or antenna.
  • the integrated circuit (200) must ensure biocompatibility by ensuring that the package material of the integrated circuit is compatible with the body, taking into consideration issues such as packaging heat generation, and the chip must not be affected during encapsulation formation.
  • the integrated circuit (200) can be used as a package material without limitation as long as it is a material commonly used in the body in the relevant field, but PDMS (Polydimethylsiloxane), Parylene C, Polyimide, and biocompatible UV resin are suitable.
  • PDMS Polydimethylsiloxane
  • Parylene C Parylene C
  • Polyimide Polyimide
  • biocompatible UV resin biocompatible UV resin
  • brain waves when brain waves are measured through an electrode (111) exposed to the outside at a contact portion (110) of an interpolation element (100), for example, a graphene electrode layer, and transmitted to an integrated circuit (200), the brain waves can be wirelessly transmitted to the outside through the integrated circuit (200).
  • an interpolation element for example, a graphene electrode layer
  • the chip controller (240) When an abnormality is detected in the brain wave signal measured by the chip controller (240), it is transmitted to the outside through a wireless communication device (250) and a command is transmitted to the stimulator (230) to apply an electrical stimulation signal to the Neural Micro Electrode, i.e., the electrode (111).
  • the stimulator (230) varies depending on the number of electrical stimulation channels.
  • the stimulator (230) can generate or transmit a therapeutic stimulus commanded by the chip controller (240).
  • Brain waves measured through the contact portion (110) of the interpolation element (100) can be converted into a digital signal through a recorder (220) and transmitted to an integrated circuit (200), which can be wirelessly transmitted to a smart device such as a smart phone, a smart pad, or a computer.
  • a recorder (220) can be included.
  • radio waves received from the outside through the integrated circuit (200) can be transmitted to the brain through the interpolation element (100).
  • the integrated circuit (200) can be controlled to provide an electric signal, etc. to the contact portion (110).
  • the integrated circuit (200) can transmit a command to a stimulator (230) to stimulate the cerebral cortex.
  • One or more stimulators (230) can be included.
  • the integrated circuit (200) may play a role in transmitting external radio waves received by a separate wireless communication device to the integrated circuit through electrodes or antennas, thereby transmitting the external radio waves to the brain rather than accepting them as they are.
  • the present invention may include additional components to improve the adhesion of the contact portion (110) to wet biological tissue.
  • the surface of the insulating layer (the layer that blocks the electrode formed on the inside) formed on the contact portion may include a hydrophilic functional group bonded by hydrophilic surface treatment.
  • the hydrophobic microstructure formed on a portion of the surface of the lower support substrate on the opposite side may additionally be included.
  • the contact portion (110) of the present invention may have a hydrophilic treatment on the side that directly contacts the brain cortex, and a hydrophobic treatment on the opposite side.
  • the contacting side may be prevented from turning over.
  • the present invention can provide a method for measuring brain signals and a method for stimulating the brain using a system (10) including a brain cortex electrode and a wireless device.
  • the contact portion (110) can contact the cerebral cortex and receive electrical signals generated in the brain. Specifically, the graphene electrode layer among the contact portions (110) of the interpolation element (100) measures electrical signals. These are transmitted to the integrated circuit (200) connected to the transceiver (130) through the wiring layer, and brain signals received through the terminal can be visually provided as described below.
  • the transceiver (130) is located in the space between the skull and the skin and can receive external stimuli and transmit them to the cerebral cortex. Specifically, the transceiver (130) can receive external stimuli and transmit them to the cerebral cortex.
  • the transceiver (130) may be connected to an integrated circuit (200), and the integrated circuit (200) may be in contact with the surface of the skull or inserted into the skull.
  • the system (10) including the brain cortex electrode and wireless device of the present invention may additionally include an amplifier.
  • This amplifier may amplify the electric signal measured from the electrode of the interpolation element (100) of the present invention.
  • the system (10) including the brain cortex electrode and wireless device of the present invention has been described as being injected into the brain, but the location where the interpolation element (100) is injected can be inserted or implanted into the spinal cord, peripheral nerves, etc., within the range applicable to a person skilled in the art.
  • the system (10) including the brain cortex electrode and wireless device of the present invention can be used in vitro, ex vivo, and in vivo.
  • the living organism is an animal, and may include a human, but may also be an animal other than a human.
  • the system (10) including the brain cortex electrode and the wireless device of the present invention provides a medical device.
  • the medical device of the present invention may include an integrated circuit (200) connected to a transceiver (130) of an interposer (100).
  • the interposer (100) may be injected only into a skull area of several mm 2 to several cm 2 , and the contact portion (110) of the interposer (100) may be in contact with the cerebral cortex, and the integrated circuit (200) may be connected to the transceiver portion (130) of the interposer (100) and may be installed between the skull and the skin, and may preferably be in contact with the surface of the skull, or may be inserted into the skull.
  • a part of the lower portion of the integrated circuit (200) may be exposed to the lower side of the skull.
  • the contact portion (110) of the interposer (100), which is in contact with the brain through the exposed lower portion, may be connected to the integrated circuit (200) through the connection portion (120).
  • the present invention can provide a brain cortex electrode and stimulation module that additionally includes a wireless communication device that directly transmits external radio waves to the circuit (200).
  • a wireless communication device that directly transmits external radio waves to the circuit (200).
  • a wireless module such as Bluetooth or a wireless communication network (Wi-Fi) within the interpolation element (100) and the integrated circuit (200)
  • a wireless communication device can be additionally used for safer signal transmission and reception through BCC (Body Channel Communication).
  • external radio waves received through a wireless communication device are transmitted to the integrated circuit through the BCC antenna. Through this, it is possible to perform the role of transmitting external radio waves to the brain through the BCC antenna rather than accepting them as they are.
  • the wireless communication device is not limited to anything that can receive external stimuli and transmit them to an integrated circuit, and may be a device that adheres to the skin. For example, it may be a smart device worn on the wrist, waist, etc.
  • the wireless communication device can communicate with external terminals such as computers and smartphones via Bluetooth, Wi-Fi, etc., and provide various information to the user through measured brain wave signals, and can transmit stimulation transmitted from the terminal to the integrated circuit (200). Additionally, it can also be equipped with a function that can transmit information to a medical institution when an emergency signal occurs.
  • the present invention can also provide a method for stimulating the brain by implanting a brain cortex electrode into the brain of an animal.
  • the animal may exclude humans.
  • a stimulation command is transmitted from the outside, it is transmitted to the integrated circuit (200) through the electrode or antenna, and the stimulation can be provided to the cerebral cortex through the interpolation element (100) of the present invention.
  • brain stimulation can be achieved through the following process. If an abnormality such as a seizure is detected in brain waves measured through the interpolation element (100), the integrated circuit (200) can receive it and provide it to the outside. If it is determined through the provided information that stimulation from the outside is necessary, the information is transmitted to the integrated circuit (200) and then the stimulation can be transmitted to the electrode of the interpolation element (100) through a stimulator (Strimulator; 230) in the integrated circuit (200) so that electrical stimulation is transmitted to the cerebral cortex. Through this process, abnormal brain wave signals can be removed.
  • an abnormality such as a seizure is detected in brain waves measured through the interpolation element (100)
  • the integrated circuit (200) can receive it and provide it to the outside. If it is determined through the provided information that stimulation from the outside is necessary, the information is transmitted to the integrated circuit (200) and then the stimulation can be transmitted to the electrode of the interpolation element (100) through a stimulator (Strimulator; 230) in the integrated circuit (200)
  • the present invention aims to provide stimulation to the cerebral cortex through an interpolation element (100).
  • the stimulation is not limited thereto, but may be at least one selected from current stimulation, voltage stimulation, electric field stimulation, and magnetic field stimulation.
  • a system (10) including a brain cortex electrode and an inductive coupling technology-based wireless device includes an integrated circuit (200) comprising an interpolation element (100), a housing (300), and a laminated portion (260); wherein the integrated circuit (200) is connected to the transceiver (130) to transmit and receive signals, and may have a laminated structure.
  • the integrated circuit (200) may transmit and receive information obtained through the interpolation element (100). For example, it may utilize electronic communication.
  • the integrated circuit (200) may include a power supply and may be capable of wireless communication.
  • the integrated circuit (200) may have a laminated structure.
  • each device including a power supply, a PCB, an IC, etc., may have a laminated structure to minimize the volume. A detailed description will be given later.
  • FIG. 4 is a schematic diagram of a system including a brain cortex electrode and an inductive coupling technology-based wireless device according to an embodiment of the present invention.
  • the housing (300) may have a structure with a width (X) of 25 mm, a length (Y) of 25 mm, and a height (Z) of 10 mm, and may include an upper case (310) that protects the upper direction of the laminated portion (260); a side case (320) that has a height higher than the height of the laminated portion (260) and has a through-hole (321) on at least a portion of one side; and a lower case (330) formed on the lower side of the laminated portion (260).
  • an upper case (310) that protects the upper direction of the laminated portion (260)
  • a side case (320) that has a height higher than the height of the laminated portion (260) and has a through-hole (321) on at least a portion of one side
  • the housing (300) may play a role in protecting devices included in the integrated circuit (200). Specifically, it may include a laminated portion (260) and a part of an interpolated element (100) inside, and protect the embedded devices from the outside of the wireless device so that they can operate electrically.
  • the upper case (310) may be formed on the upper side of the laminated portion (260) to protect the laminated portion (260).
  • the side case (320) may be formed on the side of the laminated portion (260) to protect the laminated portion (260). At this time, the side case (320) protecting the laminated portion (260) may have a length greater than the height of the laminated portion (260).
  • the lower case (330) may be formed on the lower side of the laminated portion (260) to protect the laminated portion (260).
  • Each configuration of the housing (300) formed as described above may be combined, and the upper case (310) and the lower case (330) may have the same size.
  • the upper case (310) and the lower case (330) may have a width greater than the width of the laminated portion (260).
  • the side case (320) may have a height greater than the height of the laminated portion (260). Accordingly, the laminated portion (260) formed inside by the upper case (310), the side case (320), and the lower case (330) can be protected.
  • the housing (300) may be configured to surround the laminated portion (260) and form at least a portion of space.
  • the housing (300) may be configured in a square shape so that at least a portion of space is formed between the laminated portion (260) and the housing (300), specifically, between the side of the laminated portion (260) and the side case (320).
  • a signal may be well transmitted to the outside through the antenna constructed in the PCB (214) or a signal received from the outside by the antenna may be well transmitted.
  • the integrated circuit (200) integrated by the housing (300) may protect electrical components inside the housing (300) from substances present in the body when the interpolation element (100) acquires and transmits a signal generated from the cerebral cortex and receives and processes it.
  • the integrated circuit (200) may be connected, at least in part, to a transceiver (130).
  • a through-hole (321) having a shape in which a part of the side case (320) is removed may be provided so that a transceiver (130) extending from the contact portion (110) can be inserted into the housing (300).
  • the through-hole (321) may have a shape that matches the transceiver (130) and may have a larger size than the transceiver (130).
  • the transceiver (130) may be formed so that at least a portion thereof penetrates the through-hole (321).
  • the penetration portion (321) may be a shape in which a part of the side case (320) is removed. Specifically, it may be a shape in which a part is removed so that a gap is formed in which the transmitting and receiving unit (130) that is extended to the contact portion (110) can maintain a penetrated state.
  • the transceiver (130) may have an extended shape from the contact portion (110) and the connection portion (120), and accordingly, at least a portion of the transceiver (130), the connection portion (120), or the contact portion (110) may be formed in the through-hole (321). Accordingly, at least a portion may be formed to pass through the through-hole (321) of a shape in which it is detached.
  • the side case (320) of the present invention may be provided with an intrusion prevention section to prevent external substances from entering through the empty space formed between the through-hole (321) and the transceiver (130) after the transceiver (130) is inserted into the through-hole (321).
  • an intrusion prevention section to prevent external substances from entering through the empty space formed between the through-hole (321) and the transceiver (130) after the transceiver (130) is inserted into the through-hole (321).
  • it may have a waterproof structure made of a material such as rubber or plastic.
  • the upper case (310) may be formed of a synthetic resin material (preferably plastic), and the side case (320) and the lower case (330) may be formed of a metal material (preferably titanium material).
  • the upper case (310) may be formed of synthetic resin to ensure smooth communication of signals generated from the laminated portion (260) formed inside the housing (300).
  • side case (320) and the lower case (330) may be formed of titanium.
  • side case (320) and the lower case (330) are formed of titanium, there may be no effect from future MRI examinations or high-frequency procedures.
  • the upper case (310) is formed of titanium, it may be preferable for the upper case (310) to be formed of plastic as it can serve as a shield to block communication occurring in the laminated portion (260).
  • the laminated portion (260) may include a receiver coil (213), a battery (212), a PCB (214) having an IC chip inserted therein, and at least a part of the transceiver portion (130).
  • the receiver coil (213) may be a receiver coil and may receive power from the outside, and the battery (212) may be a flat cylindrical battery.
  • An IC can mean a complex, ultra-small structured low-cost device or system in which many electronic circuit components are inseparably combined on a single substrate or on the substrate itself. It can be a device in which complex electronic components such as transistors, diodes, resistors, and capacitors are precisely manufactured and configured as a single electronic circuit in a small semiconductor. For example, instead of using individual semiconductors separately, it can be a device in which thousands or tens of thousands of semiconductors are gathered and stacked one on top of another on a silicon plane. Such an IC can be installed on a PCB (214) described below.
  • a PCB printed circuit board; 2114 may be a board that forms an electronic circuit by fixing an IC (integrated circuit) to the surface of a printed wiring board and connecting parts with copper wires.
  • the PCB (214) may include parts that enable wireless communication, such as an antenna.
  • information obtained from the interpolation element (100) can be transmitted to the outside and information from the outside can be received.
  • the transceiver (130) of the laminated portion (260) is formed on the lowest layer and may be laminated in the following order: transceiver (130), PCB, IC (since the IC is fixed on the PCB), battery (212), and receiver coil.
  • the transceiver (130) is connected to the connecting portion (120) that is formed as an extension of the contact portion (110), and may be formed at the lowest end of the stacked portion (260) so as to minimize the stress on the interpolation element (100).
  • the transceiver (130) of the interpolation element (100) is located at the highest end of the stacked portion (260), it must be connected to the contact portion (110) of the interpolation element (100) that contacts the cerebral cortex present at the lower side of the skull, and thus may be excessively bent, which may cause stress to be concentrated on the interpolation element (100) itself and cause damage.
  • the transceiver (130) may be formed at the lowest end of the stacked portion (260).
  • the transceiver (130) is arranged on the lower side of the PCB in the stacked portion (260) and connected to the PCB.
  • the PCB may be configured so that the upper side faces the battery (212) and the lower side is connected to the transceiver (130).
  • the transceiver (130) may be connected to the upper side of the PCB in the laminated portion (260).
  • the PCB may be configured so that the upper side is connected to the transceiver (130) and the lower side faces the battery (212).
  • the transceiver (130) may be connected to the side of the PCB in the laminate (260).
  • the PCB may be configured so that the upper side faces the battery (212), but the lower side may be the lowest side of the laminate (260).
  • the transceiver (130) may be connected to the upper side of the PCB in the laminate (260).
  • the PCB may be the lowermost side of the laminate (260) and may be configured so that the upper side is connected to the transceiver (130).
  • the transceiver (130) may be placed between the PCB and the battery (212).
  • the housing (300) in the present invention may be configured to form at least some space while surrounding the laminated part (260).
  • the housing (300) may be configured in a square shape so that at least some space is formed between the laminated part (260) and the housing (300), specifically, between the side of the laminated part (260) and the side case (320).
  • the PCB (214) may be arranged as in the above-mentioned embodiment, but may additionally be configured so that the PCB (214) is arranged on the inside of the side case (320).
  • the area required for the PCB (214) can be reduced, thereby having the effect of reducing the overall volume of the laminated portion (260).
  • the housing (300) illustrated in FIG. 16 has a circular shape, and the PCB (214) arranged on the inside of the side case (320) may be an FPCB (Flexible PCB).
  • the battery (212) may be formed in a circular shape, and the housing (300) may be provided in a square shape.
  • the battery (212) may act as an interference factor when generating a signal for information transmission. To minimize this, it may be formed in a circular shape.
  • the housing (300) may be provided in a square shape to optimize signal generation.
  • each component of the laminated portion (260) can be electrically connected.
  • the laminated portion (260) may be a device for reading and transmitting brain signals and receiving and controlling external signals through the interpolation element (100).
  • the components of the laminated portion (260) may be electrically connected for transmitting and receiving information.
  • the transceiver portion (130), the PCB (214), the battery (212), and the receiver coil (213) are electrically connected to each other, so that the power received from the receiver coil (213) is stored in the battery (212), and the electrical energy stored in the battery (212) can be appropriately transmitted to the PCB (214) and the transceiver portion (130).
  • FIG. 5 is a drawing schematically showing an example of an interpolation element (100) according to another embodiment of the present invention
  • FIG. 6 is a drawing schematically showing another example of an interpolation element (100) according to another embodiment of the present invention
  • FIG. 7 is a drawing schematically showing yet another example of an interpolation element (100) according to another embodiment of the present invention.
  • the contact portion (110) may be formed such that the substrate is elongated in the longitudinal direction.
  • the contact portion (110) may have, for example, a longitudinal direction of 60.0 mm and a width direction of 15.0 mm.
  • the longitudinal direction is the horizontal direction of FIG. 5, and the width direction is the vertical direction of FIG. 5.
  • the contact portion (110) when the contact portion (110) contacts the cerebral cortex, it can contact the motor cortex and may have a length that can cover the outer surface of the motor cortex.
  • the contact portion (110) may have a rectangular shape and at least one electrode (111) may be formed.
  • the electrode (111) can receive signals generated from the brain and transmit signals to the brain using electrical stimulation.
  • the electrode (111) may be formed only on the front surface of the contact portion (110), or may be formed only on the rear surface. Additionally, it may be formed on both sides by penetrating the contact portion (110).
  • the contact portion (110) may be formed in multiple numbers on both sides based on the transceiver portion (130).
  • the contact portion (110) is connected to the transceiver (130) by the connection portion (120).
  • the connection portions (120) may be formed on both sides and each connection portion (120) may be connected to the contact portion (110).
  • the contact portion (110) may include a left end portion (140), a middle portion (150), and a right end portion (160).
  • the contact part (110) side can be defined as the left side and the transceiver (130) side can be defined as the right side.
  • the left end (140) may be an area formed on the left side of the contact portion (110) and may be an area where the most electrodes (111) are formed.
  • the right end (160) may be the area closest to the integrated circuit (200) and may have the fewest number of electrodes (111).
  • the intermediate portion (150) may be an area connecting the left end (140) and the right end (160), and the number of electrodes may be intermediate between the left end (140) and the right end (160).
  • the electrodes may be made heavier by pushing them into the left end (140) compared to the middle end (150) and the right end (160) so that they are well-positioned on the brain surface.
  • the lower part of the motor cortex where the left end (140) is settled has many nerves distributed (more nerves are distributed to the eyes, nose, mouth, etc. than to the feet, knees, etc.) and accordingly, many electrodes are required for stimulation or brain wave detection, which may improve the efficiency of stimulation and data reception.
  • the interpolation element (100) in contact with the cerebral cortex may be formed in the order of the left end (140) being formed at the far left, the left end (140), the middle end (150), and the right end (160).
  • it can be in the order of the right end (160), the middle end (150), and the left end (140) from the integrated circuit (200).
  • the heaviest left end (140) is formed to bend toward the cerebral cortex, thereby making it easy to settle on the cerebral cortex.
  • the density of the electrodes may increase as they move from the right end (160) to the left end (140).
  • Electrode density can mean the number of electrodes present per unit area.
  • a high density means that there are many electrodes per unit area.
  • the electrode can have a certain weight, and the weight can become heavier as the electrode density increases.
  • the left end (140) when attached to the brain due to the increased weight, the left end (140) can be completely secured to the end without being lifted off from the brain cortex.
  • the location of the left end (140) may be a place where many brain signals are formed, and signals may be acquired accurately and quickly using a number of electrodes.
  • the interpolation element (100) may be formed of an elastic material.
  • the interpolation element (100) may be formed to be bent downwards toward the integrated circuit (200), the right end (160), the middle end (150), and the left end (140) so as to be in close contact with the brain.
  • the interpolation element (100) may be formed to be bent in a direction from the upper side to the lower side of the brain so as to be in close contact with the brain.
  • interpolation elements (100) are formed to have elasticity, so that when they are placed on the meninges, they can be additionally bent at a certain angle.
  • the connecting portion (120) connecting the contact portion (110) and the transceiver portion (130) may have a thinner width than the contact portion (110) or the transceiver portion (130).
  • a connecting portion (120) with a thinner width than the contact portion (110) at the right end of a rectangular-shaped contact portion (110) may be connected to the transceiver (130).
  • the connecting portion (120) may serve to physically connect the contact portion (110) and the transceiver (130) while allowing electrical movement.
  • connection (120) can minimize material waste and improve flexibility.
  • FIG. 8 is a drawing schematically showing an example of a left end (140) according to another embodiment of the present invention.
  • the end of the left end (140) may include a step (141).
  • the step (141) may be formed to have a certain weight so that when the interpolation element (100) comes into contact with the meninges, all of the ends are settled in the brain.
  • the step (141) has a certain weight
  • the step portion (141) may be provided in a rectangular shape.
  • a step (141) with the thickness of the interpolation element (100) may be additionally formed at the end of the left end (140) to allow contact with the meninges.
  • the step portion (141) may have a gradient structure in which the thickness becomes thicker as it goes toward the left end (140).
  • the gradient structure may be a structure that minimizes the space between the meninges and the interpolation element (100) when the interpolation element (100) is settled on the meninges.
  • the gradient structure may allow for a flexible fit when a part of the meninges aligns with the shape of the step (141).
  • the thickness of the end of the right end (160) may be 16 ⁇ m, and the thickness of the end of the left end (140) may be 18 to 20 ⁇ m.
  • the end of the right end (160) may be the end on the transceiver side (130).
  • end of the left end (140) may be the opposite end of the transceiver (130).
  • the interpolation element (100) When the interpolation element (100) is installed in the brain, it can be installed well in an irregular brain shape due to the end of the left end (140) being formed thicker than the end of the right end (160).
  • FIG. 9 is a drawing schematically showing an example of a connecting portion (120) according to another embodiment of the present invention
  • FIG. 10 is a drawing schematically showing another example of a connecting portion (120) according to another embodiment of the present invention
  • FIG. 11 is a drawing schematically showing yet another example of a connecting portion (120) according to another embodiment of the present invention.
  • the connecting portion (120) may be provided with a plurality of substrates (1201) having a wire shape.
  • the contact portion (110) may be formed as a large-area multi-channel surface electrode.
  • the connecting portion (120) connected to the transceiver (130) is manufactured in a film-like shape (lateral), there is a disadvantage in that the width of the lateral shape increases and a wide incision of the scalp is required during surgery.
  • the connecting portion (120) is provided with a bundle of wire-shaped substrates (1201), so that the contact portion (110), which is a large-area flexible electrode, has an advantage in that a wide scalp incision is not required when the contact portion is inserted into the cerebral cortex and then connected to an external measuring terminal.
  • the plurality of wire-shaped substrates may be formed by separating a plate-shaped substrate into a plurality of wire shapes. At this time, wiring may be formed on each of the plurality of wire-shaped substrates and separated by wiring.
  • the multiple wire-shaped substrates may be provided in different colors. This may be to easily distinguish multiple wires by wiring.
  • the connecting portion (120) having a plurality of wire-shaped substrates may be formed into a bundle using a shrink tube (121) described later. This can increase rigidity.
  • the connecting portion (120) having a plurality of wire-shaped substrates may be compressed using a shrink tube (121).
  • the connecting part (120) provided in the shape of a thin wire can be connected by passing through the incised skin. At this time, a breakage may occur due to the weak rigidity of the connecting part (120). To prevent this, a plurality of wire-shaped substrates may be combined into one.
  • the shrink tube (121) may be formed to have a certain rigidity and may be used to bundle a plurality of wire-shaped substrates into a single line shape. When the bundled plurality of wire-shaped substrates pass through the skull, they can have rigidity while minimizing volume.
  • the shrink tube (121) may be a flexible material that coats a plurality of bundled wire-shaped substrates.
  • connecting portion (120) may be formed to have a serpentine structure to absorb strain applied to the portion connected to the transceiver (130), and this portion may be coated with soft rubber or, for example, silicone.
  • the connecting portion (120) may have at least a portion having a serpentine structure.
  • the winding structure may be a substrate (1201) having a wire shape having a certain shape.
  • it may have a curved shape that becomes wider as it gets closer to the contact portion (110).
  • the material used to manufacture the interpolation element (100) has a paraffin content of 6-7% or less and gold of 1% or less, so the elasticity is not high, and furthermore, the structure of the electrode has a negative effect on the elasticity. Therefore, when a process of wrapping the wire-shaped substrate (1201) by bundling it together with silicone or a shrink tube (121) is performed, the pressure (strain) that occurs is concentrated on a specific area. In this case, if the pressure (strain) is concentrated on a part with weak durability, there is a risk of breakage or damage.
  • the connecting portion (120) may be formed by wire-shaped substrates (1201), but at least some of the wire-shaped substrates (1201) may have a serpentine structure.
  • the winding structure of this connection (120) can cause the pressure (strain) concentrated in a specific area to be concentrated in the connection (120) because the effective stiffness of the winding structure is significantly smaller than that of other materials.
  • the outermost wire-shaped substrate (1201) may experience a strain that pulls it inward. Accordingly, the wire-shaped substrate (1201) formed at the outermost end can have the most curved shape.
  • the connecting portion (120) formed as described above may minimize strain by increasing the length as the winding region spreads out when the wire-shaped substrate (1201) is joined together.
  • the substrate (1201) having a wire shape of the connecting portion (120) may have a curved shape only in a portion close to the contact portion (110).
  • the pressure (strain) that occurs occurs in a portion close to the contact portion (110), and among them, it can be strongly applied to the wire-shaped substrate (1201) located outside. Accordingly, the wire-shaped substrate (1201) may be provided so that only the portion close to the contact portion (110) of the connecting portion (120) has a curved shape.
  • the area of the contact portion (110) connected to the connecting portion (120) may be provided in a ‘v’ shape.
  • the substrates (1201) having a wire shape with a winding structure of the connecting portion (120) are connected to the contact portion (110), it may be to secure the length as much as possible and minimize the pressure (strain) that occurs.
  • the inner wire-shaped substrate (1201) may be formed so that the length of the wire-shaped substrate (1201) becomes longer as it goes toward the outside.
  • the wire-shaped substrate (1201) of the connection portion (120) may have 64 channels of wiring.
  • the wire-shaped substrate (1201) has wiring (1202) formed on the substrate, and 20 wire-shaped substrates (1201) including three wirings (1202) are formed, and one wire-shaped substrate (1201) including two wirings (1202) is formed on each of the two sides of the 20 wire-shaped substrates (1201), so that a total of 64 wirings (1202), i.e., 64 channels of wiring (1202) can be formed.
  • the width (W1) of the wiring (1202) is formed to a size of 10 to 30 um (preferably 15 um), and the width (W2) of one wire-shaped substrate (1201) is formed to a size of 50 to 200 um (preferably 85 um), so that preferably, the total width (width; W3) of the wire-shaped substrate (1201) can be formed to 2.24 mm.
  • the thickness (D) of the wire-shaped substrate (1201) can be manufactured to be 15 um or more.
  • the number of wirings (1202) that can be formed on one wire-shaped substrate (1201) can be changed according to the design.
  • a substrate (1203) that connects the wire-shaped substrates (!201) to each other can be formed, and this connecting substrate (1203) can connect the wire-shaped substrates (1201) at an angle of 45 degrees.
  • the connecting board (1203) is connected at a 90 degree angle, the high rigidity in the X-axis direction can prevent the wire-type boards (1201) from clumping together, so that the connecting board (1203) can connect the wire-type boards (1201) at a 45 degree angle.
  • This 45 degree angle can prevent the wire-type boards (1201) from being torn due to the high rigidity in the X-axis direction when the connecting portion (120) is forcibly clumped together when wrapping it with a shrink tube (121) or silicone, etc.
  • the connecting boards (1203) are connected at a 90 degree angle, the high rigidity in the X-axis direction can induce the wire-type boards (1201) to be torn, but this can be prevented when the connecting boards (1203) are connected at a 45 degree angle.
  • the y-axis (A2) length of the wire-shaped substrate (1201) of the connecting portion (120) may be formed to be 10 times or more longer than the x-axis (A1) length.
  • the wire-shaped substrates (1201) may be induced to easily assemble with each other by making the elastic energy accumulated in the y-axis (A2) direction 0 while allowing them to be well clumped together in the x-axis (A1) direction. This may also allow the pressure (strain) to be concentrated on the connecting portion (120).
  • a thinly formed wire-shaped substrate (1201) may have flexibility when bunched in the x-axis (A1) direction, but may cause problems such as tearing or breaking.
  • the area of the contact portion (110) connected to the wire-shaped substrate (1201) may be provided in an 'A' shape (110a).
  • the 'A' shape (110a) may be a cone-shaped shape with a pointed center, and a wire-shaped connecting part (120) may be connected to the inside of the 'A' shape (110a).
  • the contact portion (110) having a lower portion in the shape of an 'A' (110a) can reduce stress so as to prevent tearing due to pulling of the wire-shaped substrate (1201) when the wire-shaped substrate (1201) of the connection portion (120) is bunched in the x-axis direction.
  • the wire-shaped connection portion (120) formed as described above has the effect of minimizing the area of the scalp to be cut when connecting to an external measurement unit after inserting a large-area interpolation element (100).
  • FIG. 12 is a drawing schematically showing an example of a system including a guide part (410) according to another embodiment of the present invention
  • FIG. 13 is a drawing schematically showing a guide part (410) including a fixing member (470) according to another embodiment of the present invention.
  • a system (10) including a brain cortex electrode and an inductive coupling technology-based wireless device is a system for inserting a brain cortex electrode into a surface of the cerebral cortex, including a pocket portion (400) provided in a pocket shape and having a predetermined space formed inside; and a guide portion (410) which is a guide structure that can be inserted into the inside of the pocket portion (400) and has at least a portion in the shape of a hard rod so that the brain cortex electrode can be pushed in; and may include an interpolation element (100); which measures a signal generated in the brain by contacting the surface of the cerebral cortex or transmits an external stimulus to the brain.
  • the brain cortex electrode may mean an interpolation element (100).
  • it may be one that directly contacts the brain cortex to receive signals from the brain or transmit information received from the outside to the brain.
  • interpolation element (100) may be a flexible material substrate (electrode) such as the interpolation element (100) described above, but is not limited thereto.
  • the interpolation device (100) may be inserted by cutting open the skull in order to contact the cerebral cortex.
  • the interpolation device (100) may be formed in the shape of the interpolation device (100) described above, and the interpolation device (100) may be inserted by cutting open the skull in a width that allows the interpolation device to be inserted, and using the pocket portion (400) and the guide portion (410). A detailed description will be given later.
  • the pocket part (400) may be a predetermined space into which the guide part (410) is inserted.
  • the pocket part (400) may be formed at the longitudinal end of the interposer (100), and may be formed anywhere on one side, the other side, or the middle side in the width direction, but may be preferably formed on the middle side.
  • the pocket part (400) may be formed with the front side open so that the lens of the camera (420) formed in the guide part (410) can look forward when inserted.
  • the pocket part (400) does not have a form in which the front is completely open, but rather has a form in which at least a portion, preferably only the central portion, is open, thereby preventing the guide part (410) inserted into the pocket part (400) from passing through the pocket part (400) and securing a front view. That is, the pocket part (400) may include a shooting hole (440) that is open at least in a portion.
  • the material of the interpolation element (100) may be formed of a flexible material, and only the portion where the pocket portion (400) is formed may be formed of a material with high rigidity. When the interpolation element (100) is pushed in, damage to the cerebral cortex can be minimized, while the interpolation element (100), which has low rigidity compared to the guide portion (410), can be prevented from being folded or torn.
  • the interpolation element (100) may include a reinforcing plate (430) to prevent the end of the interpolation element (100) from being torn.
  • the reinforcing plate (430) may be formed by adding a high-rigidity material to the portion where the pocket portion (400) of the interpolation element (100) is formed. Through this, the end of the interpolation element (100) pushed in through the guide portion (410) may be prevented from being folded or torn, while allowing the entire interpolation element (100) to be secured to the cerebral cortex.
  • the guide part (410) is formed so that it can be inserted into the pocket part (400), and after being inserted, it can be pushed in to insert the device (100) into the skull along the cerebral cortex. At this time, the guide part (410) can be inserted into the pocket part (400) and push the pocket part (400) to push in the entire interposer (100).
  • the guide part (410) can be formed of a material that is stiffer than the interposer (100) to guide the interposer (100).
  • the guide part (410) may include a camera (420) at the end that comes into contact with the pocket part (400).
  • the camera (420) may be an endoscope camera (420). It may be a means for checking the inside of the opened brain.
  • a wire connected to a camera (420) may be formed inside the guide portion (410).
  • the camera (420) formed in the guide section (410) may be configured to photograph the front side of the pocket section (400) that is pushed in. At this time, lighting for photographing may be formed, or conversely, it may be an infrared camera (420) that does not require light.
  • the pocket part (400) may be formed with a shooting hole (440) that is open at least in part to enable shooting with the camera (420) while being pushed in by the guide part (410).
  • the shooting hole (440) may have a size that allows the camera (420) to take pictures, and may be formed in the center of the front side of the pocket part (400).
  • the part of the guide part (410) other than the camera (420) part may be structured to be blocked so that the guide part (410) cannot pass through.
  • the guide unit (410) can push the element (100) into the cerebral cortex while filming.
  • the interpolation element (100) may include a catch groove (450) at both ends of the lower side, and the guide part (410) may include at least one catch portion (460) having a protruding shape so as to be caught in the catch groove (450).
  • the guide part (410) may include a first guide structure (411) and a second guide structure (412).
  • the catch groove (450) may be formed at the lower end of the interpolation element (100).
  • the catch groove (450) may be in the form of a concave groove or through hole formed in the downward direction on both sides of the lower end of the interpolation element (100).
  • the catch portion (460) may be formed smaller than the catch groove (450). For example, if the catch portion (460) is formed larger than the catch groove (450), the catch portion (460) may not be caught in the catch groove (450), and this may be prevented.
  • the guide part (410) may be formed by forming a single catch (460), but is not limited thereto, and may be formed in multiple forms. This is to prevent the singly formed catch (460) from falling out when the insertion element (100) is pushed in by being caught in the catch groove (450), and through the configuration of the catch grooves (450) and catch portions (460) formed in multiple forms on both sides of the insertion element (100), it is possible to prevent the insertion element (100) from falling out due to movement by being inserted from both sides.
  • the guide part (410) may include a fixing member (470) on the middle side for fixing a plurality of the guide parts (410) so as to be spaced apart at a predetermined distance in the width direction.
  • the fixed member (470) can prevent each of the first and second guide structures (411, 412) from widening or narrowing in the width direction and keep them spaced apart at a certain interval.
  • the first and second guide structures (411, 412) that are connected may be formed to have the same length from the connected portion to the bottom, and the fixing member (470) may be formed to have the same width as the width of the insertion element (100).
  • both sides can be pushed equally.
  • These catches (460) are formed to protrude in the width direction from each of the first and second guide structures (411, 412), and may be formed in the shape of a ' ⁇ ' shaped hook.
  • the fixed part (470) is formed to be rotatable when connected to each guide part (410), so that the catches (460) can be caught and released from the catch groove (450) by rotation.
  • the catch groove (450) may be formed to have a size smaller than or equal to the size of the catch portion (460).
  • the catch (460) formed in the guide (410) is caught in the catch groove (450) and performs the function of pushing in the insertion element (100).
  • the catch portion (460) may be formed smaller than the catch groove (450) or may have a specific shape.
  • the catch groove (450) is provided in a circular or square shape
  • the catch portion (460) may have a hook shape of the letter ' ⁇ ' or a ' ⁇ ' shape, but may be configured such that the opening of the ' ⁇ ' shape faces downward, or a protruding member facing forward may be additionally configured at the lower end of the hook of the ' ⁇ ' shape to provide a stronger fixing force when pushed forward.
  • At least one of the first and second guide structures (411, 412) may form a camera (420) at each lower end.
  • the camera (420) can capture images of the cerebral cortex inside the skull, and the first and second guide structures (411, 412) made of hard materials on both sides can guide the operator to position the intraocular element (100) at an accurate location without damaging the brain as it is pushed in.
  • FIG. 14 is a schematic diagram illustrating another example of a system according to another embodiment of the present invention
  • FIG. 15 is a schematic diagram illustrating another example of a system according to another embodiment of the present invention.
  • (a) is a block diagram schematically illustrating a system according to another embodiment of the present invention
  • (b) is a cross-sectional diagram of a system according to one embodiment of the present invention
  • (c) is a cross-sectional diagram of a system according to another embodiment of the present invention.
  • the contact portion (110) of the interpolation element (100) of the system can be integrated with the brainwave collection device (200a) that collects brainwave information of the integrated circuit (200), that is, the converter (ADC; 291), the chip controller (240), and the recorder (220).
  • the brainwave collection device (200a) that collects brainwave information of the integrated circuit (200), that is, the converter (ADC; 291), the chip controller (240), and the recorder (220).
  • the brainwave collection device (200a) can store the signal when the interpolation element (100) is installed in the cerebral cortex and receives the signal from the brain, and can convert analog information into digital information.
  • an EEG collection device (200a) may be provided at a contact portion (110) of an interpolation element (100).
  • the contact portion (110) may include an electrode array (111) arranged on a substrate (112) at a portion (distal portion) far from a connection portion (120), and an EEG collection device (200a), i.e., an amplifier (amp; 290), a converter (ADC; 291), a chip controller (249), and a recorder (220) at a portion (proximal portion) close to the connection portion (120).
  • Such brain wave collection devices (200a) may malfunction due to moisture if directly exposed to the outside.
  • the contact portion (110) of the interpolation element (100) may be subjected to waterproof packaging.
  • the brainwave collection device (200a) formed on one side of the interpolation element (100) may be formed to be surrounded by a waterproof material (plastic, rubber, silicone, etc.).
  • the entire interpolation element (100) may be coated.
  • an interpolation element (100) including a contact portion (110) that includes an electrode (111) that contacts a surface of a cerebral cortex to measure a signal generated in the brain or transmit an external stimulus to the brain, an electroencephalographic collection device (200a) that is connected to the electrode (111) so as to be able to exchange information, that is, an amplifier (amp; 290), a converter (291), a chip controller (240), and a recorder (220); and an integrated circuit (200) that exchanges information transmitted from the interpolation element (100) with the outside and receives power; and the interpolation element (100) may include a connection portion (120) that connects the contact portion (110) and the integrated circuit (200).
  • the contact portion (110) of the interpolation element (100) may include an amplifier (amp; 290), a converter (291), a chip controller (chip controller; 240), and a recorder (220). Meanwhile, the chip controller (240) may not only be placed at the contact portion (110) of the interpolation element (100), but may also be placed outside the skull while being excluded from the contact portion (110).
  • the contact portion (110) may include an electrode (111) to receive an analog signal of the brain while in contact with the cerebral cortex. At this time, the contact portion (110) may include at least one electrode (111).
  • Analog information received through the electrode (111) of the contact portion (110) may be converted into digital information using a brainwave collection device (200a) and stored.
  • the digital information stored as described above may be transmitted to an integrated circuit (200) through wires of the connection portion (120), and the transmitted information may be transmitted to the outside of the body through wireless communication.
  • information received from the outside of the body may be converted into analog information and transmitted to a stimulator, and the stimulator may transmit a signal to the electrode (111) of the contact portion (110) to stimulate the brain.
  • the contact portion (110) and the integrated circuit (200) may be connected by a connection portion (120).
  • the connection portion (120) includes at least one wire, and may supply power or transmit or receive information from the integrated circuit (200) to the contact portion (110) through the wire.
  • connection part (120) of the interpolation element (100) may be connected to the integrated circuit (200) by only two wires. These two wires may be a power line (295) and a data line (296), and the power line (295) may be separated into a vdd wire and a ground wire.
  • the power line (295) may be a wiring for supplying power.
  • the data line (296) may be a wire for transmitting and receiving information.
  • the data line (296) may include a signal ground wire and may also be composed of a plurality of data lines.
  • the contact portion (110) of the interpolation element (100) of the present invention is integrated with the brainwave collection device (200a) that collects brainwave information, so that the connection portion (120) connected to the integrated circuit (200) has only two wires, that is, a power line (295) and a data line (296), thereby minimizing the thickness of the connection portion (120).
  • the two wires (295, 296) may further be provided with a housing surrounding the outside.
  • the integrated circuit (200) may include a wireless device (200b) based on inductive coupling technology.
  • the wireless device (200b) may include an on-chip coil (292), a current converter (293), a power management circuit (294), and a wireless chip, i.e., a wireless chip (250).
  • the current converter (293) may convert an alternating current received from the outside through the on-chip coil (292) into a direct current and then transmit the converted current to the power management circuit (294).
  • the power management circuit (294) may be connected to a chip controller (240) of a contact portion (110) of an interpolation element (100) through a power line (295), and the wireless chip (250) may be connected to a recorder (220) of a contact portion (110) of an interpolation element (100) through a data line (296).
  • the chip controller (240) is connected to the recorder (220).
  • the interpolation element (100) can store brain signals on its own and transmit the stored information to an integrated circuit (200) attached to the skull.
  • the integrated circuit (200) may transmit the stored information using a wireless communication device (250), i.e., a wireless chip, or may receive power wirelessly from the outside.
  • a wireless communication device i.e., a wireless chip
  • an encoder may be provided in the middle.
  • the contact portion (110) includes at least one electrode (111), and the chip controller (240) can form a number of channels equal to the number of electrodes.
  • the electrode (111) may be used to measure brain waves or transmit signals to the brain by contacting the cerebral cortex.
  • the number of electrodes used may be formed in large numbers, and may be formed to be able to read various signals in order to read all signals generated in the brain.
  • the electrodes that read brain waves may form as many channels as the number of brain waves.
  • the interpolation element (100) and the integrated circuit (200) may be connected by two lines (295, 296). (See (c) of FIG. 15)
  • the line When the line is formed with two lines, that is, two channels, the line can have a voltage (Vdd) line, a ground line, and a data line, and compared to the case where a large number of lines are formed, the line has fewer lines, thereby minimizing the volume and minimizing the area to be opened when connecting the integrated circuit (200) on the upper side of the skull and the interpolation element (100) in contact with the cerebral cortex.
  • Vdd voltage
  • the line has compared to the case where a large number of lines are formed, the line has fewer lines, thereby minimizing the volume and minimizing the area to be opened when connecting the integrated circuit (200) on the upper side of the skull and the interpolation element (100) in contact with the cerebral cortex.
  • the interpolation element (100) can convert analog information collected from the contact portion (110) into digital information using the chip controller (240) and transmit it to the integrated circuit (200) using the connection portion (120).
  • the analog information may be short-wave information received from the brain, which may be converted into a digital signal by the chip controller (240), and the converted digital signal may be stored by the recorder (220).
  • the stored digital information may be transmitted to the integrated circuit (200), and the integrated circuit (200) and an external transceiver may be capable of transmitting a digital signal.
  • the system can waterproof-coat the chip controller (240) and the recorder (220) together when waterproof-coating the contact portion (110).
  • the coating may be applied so that the interpolation element (100) that comes into contact with the cerebral cortex can be wetted by the liquid on the surface of the brain. At this time, the coating may be applied so as to prevent electrical connections from being discharged or leaked due to moisture.
  • the coating may be applied using rubber, silicone, or the like, but may preferably be applied using silicone.
  • the interpolation element (100) may be positioned together with the chip controller (240) and the recorder (220), and both may be coated.
  • the interpolation element (100) including a plurality of channels is formed inside the skull, and the interpolation element (100) can be connected to the integrated circuit (200) formed outside the skull through the connection portion (120).
  • the interpolation element (100) including the chip controller (240) and the recorder (220) may be formed to be in contact with the cerebral cortex inside the skull.
  • This interpolation element (100) may receive a signal generated from the brain, convert it into a digital signal, and store it. In order to transmit the information converted into a digital signal to the outside, the digital information may be transmitted to the integrated circuit (200).
  • This digital information requires only a minimum of wiring, and accordingly, the connection portion (120) connecting the interpolation element (100) and the integrated circuit (200) may have a very thin shape. Accordingly, the open portion of the skull can be formed very narrowly.
  • the contact portion (110) that receives an analog signal obtains information using a plurality of electrodes, and at this time, a plurality of channels are used. Each of these channels must have separate wiring formed, and thus a very large number of wirings are formed.
  • the analog signal obtained from the contact portion (110) may have a form having multiple wires until it passes through the chip controller (240). Multiple wires occupy a large volume, and the volume of the skull that is opened when the interpolation element (100) is inserted or used may increase, and damage to the body may occur.
  • connection portion (120) has only two wires, and for this purpose, the electrode (111) is not placed only on the contact portion (110) of the interpolation element (100), but the chip controller (240) and the recorder (220) are placed together on the contact portion (110) and integrated, rather than being placed on the integrated circuit (200), and accordingly, the volume of the connection portion (120) can be minimized.
  • the present invention may have the following first embodiment.
  • the present invention comprises an interpolation element including a contact portion for measuring a signal generated in the brain or transmitting a stimulus to the brain; a transceiver portion configured to transmit a signal received from the contact portion to the outside or to transmit a signal instructing the stimulus to the contact portion; and a connecting portion connecting between the contact portion and the transceiver portion; wherein the contact portion is formed to have a length in the longitudinal direction and includes at least one electrode, and the contact portion is characterized in that the greatest number of electrodes is formed in a portion farthest from the connecting portion.
  • the contact portion may be formed in multiple numbers on both sides of the transceiver portion.
  • the contact portion includes a right end portion where at least one electrode is formed; a left end portion formed at an end of the contact portion; and a middle portion connecting the left end and the right end; and the density of the electrodes can increase in the order of the right end portion, the middle portion, and the left end.
  • the contact portion may be formed of a material having elasticity, and the left end portion may form a step portion in which at least a portion of the left end portion has a different thickness.
  • the step portion may be a rectangular structure configured to form a preset thickness by a preset distance from the end of the left end toward the right end.
  • the step portion may be a gradient structure formed so that the thickness becomes thinner by a preset distance from the end of the left end toward the right end.
  • the connecting portion may be formed such that at least one or more wire-shaped substrates have a bundle shape.
  • the connecting portion may include a shrink tube that secures at least one or more wire-shaped substrates.
  • the connecting portion may have at least a portion of at least one wire-shaped substrate having a winding structure.
  • the present invention may have a second embodiment as follows.
  • the present invention relates to a brain cortical electrode system including an interpolation element that measures a signal generated in the brain by contacting a surface of the cerebral cortex or transmits an external stimulus to the brain, the system including a pocket portion provided in a pocket shape on one side of the interpolation element and forming a predetermined space on the inside, and the pocket portion is characterized in that a rod-shaped guide portion is formed to be inserted on the inside so as to insert the interpolation element into the surface of the cerebral cortex.
  • the interpolation element may include a reinforcing plate formed to extend to one side of the pocket portion to prevent tearing from the insertion of the guide portion.
  • the guide part may be an endoscope
  • the pocket part may include a shooting hole at least partially open so that the guide part can be inserted and shooting can be performed.
  • the interpolation element may include a plurality of pocket portions and a plurality of guide portions each inserted into the plurality of pocket portions.
  • the present invention relates to a brain cortex electrode system including an interpolation element that measures a signal generated in the brain by coming into contact with a surface of a cerebral cortex or transmits an external stimulus to the brain, wherein the interpolation element is characterized in that it has a catch groove on each of both sides of one end, and includes a catch portion having a protruding shape that can be caught in each of the catch grooves, and includes first and second guide structures in the shape of rods that allow the interpolation element to be inserted into the surface of the cerebral cortex.
  • the first and second guide structures may include a fixing member that is fixed on the middle side so that the first and second guide structures are spaced apart by a preset distance.
  • the catch portion may be formed to protrude in an ‘ ⁇ ’ shape from the first or second guide structure so as to be inserted into the catch groove.
  • At least one of the first or second guide structures may be an endoscope.
  • the present invention may have a third embodiment as follows.
  • the present invention comprises an interpolation element including a contact portion for measuring a signal generated in the brain or transmitting a stimulus to the brain, a transceiver portion configured to transmit a signal received from the contact portion to the outside or to transmit a signal instructing the stimulus to the contact portion, and a connection portion connecting the contact portion and the transceiver; and an integrated circuit for exchanging information transmitted from the interpolation element with the outside and receiving power from the outside, wherein the interpolation element includes a brainwave collection device for collecting brainwave information.
  • the contact portion may form at least one electrode
  • the brainwave collection device may include a converter (ADC) that converts analog information collected from the contact portion into digital information; a chip controller that controls the converter; and a recorder that records information converted by the converter.
  • ADC converter
  • connection may include only two lines: a power line and a data line.
  • the connecting portion may connect the power line to the chip controller and the integrated circuit
  • the data line may connect the recorder and the integrated circuit
  • the system can waterproof-coat the converter, the chip controller and the recorder together when waterproof-coating the contact portion.
  • the interpolation element is formed inside the skull, and the interpolation element can be connected to the integrated circuit formed to be inserted outside the skull or into the skull through the connection portion.
  • the integrated circuit includes a wireless power device and a wireless communication device, wherein the wireless power device can be connected to the chip controller through the power line, and the wireless communication device can be connected to the recorder through the data line.
  • the wireless power device may include an on-chip coil in the form of a coil that wirelessly receives power from an external source; a current converter that converts an alternating current transmitted from the on-chip coil into a direct current; and a power management circuit that controls power received from the current converter to be transmitted to the chip controller, and the wireless communication device may include a wireless chip that wirelessly transmits and receives data.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Signal Processing (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

La présente invention comprend : un élément d'interpolation comprenant une unité de contact pour mesurer un signal généré dans le cerveau ou émettre une stimulation au cerveau, une unité d'émission/de réception configurée pour émettre un signal reçu de l'unité de contact à l'extérieur ou émettre un signal indiquant la stimulation à l'unité de contact, et une unité de connexion pour connecter l'unité de contact et l'unité d'émission/de réception ; et un circuit intégré connecté à l'unité d'émission/de réception pour émettre et recevoir un signal, le circuit intégré présentant une structure empilée.
PCT/KR2024/018482 2023-11-21 2024-11-21 Système électroceutique implantable comprenant une électrode corticale et un dispositif de charge sans fil Pending WO2025110742A1 (fr)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
KR10-2023-0162082 2023-11-21
KR20230162082 2023-11-21
KR1020240166975A KR20250075527A (ko) 2023-11-21 2024-11-21 삽입 특성을 향상시킨 뇌피질전극 어레이
KR1020240166973A KR20250076422A (ko) 2023-11-21 2024-11-21 뇌피질전극과 무선충전장치가 포함된 인체삽입형 전자약 시스템
KR10-2024-0166975 2024-11-21
KR1020240166974A KR20250076423A (ko) 2023-11-21 2024-11-21 집중 전극 그룹 구조를 갖는 뇌피질전극 어레이
KR10-2024-0166976 2024-11-21
KR10-2024-0166973 2024-11-21
KR10-2024-0166974 2024-11-21
KR1020240166976A KR20250076424A (ko) 2023-11-21 2024-11-21 전자소자-전극 일체화 구조를 갖는 뇌피질전극 기반 전자약 시스템

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WO2025110742A1 true WO2025110742A1 (fr) 2025-05-30

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PCT/KR2024/018482 Pending WO2025110742A1 (fr) 2023-11-21 2024-11-21 Système électroceutique implantable comprenant une électrode corticale et un dispositif de charge sans fil

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Country Link
WO (1) WO2025110742A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140092238A (ko) * 2011-03-17 2014-07-23 브라운 유니버시티 이식가능 무선 신경 장치
US20150157862A1 (en) * 2013-12-06 2015-06-11 Second Sight Medical Products, Inc. Cortical Implant System for Brain Stimulation and Recording
US20190290911A1 (en) * 2018-03-21 2019-09-26 Medtronic, Inc. Implantable medical device structures including recharge and/or telemetry coil
KR20210129588A (ko) * 2020-04-20 2021-10-28 인천대학교 산학협력단 주사기 주입형 뇌 신호 측정 및 자극용 구조체 및 이의 주사기 주입 방법
US20230158302A1 (en) * 2019-09-06 2023-05-25 Nextern, Inc. Systems, Devices, Components and Methods for the Delivery of Electrical Stimulation to Cranial Nerves to Treat Mood or Mood Affective Disorders

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140092238A (ko) * 2011-03-17 2014-07-23 브라운 유니버시티 이식가능 무선 신경 장치
US20150157862A1 (en) * 2013-12-06 2015-06-11 Second Sight Medical Products, Inc. Cortical Implant System for Brain Stimulation and Recording
US20190290911A1 (en) * 2018-03-21 2019-09-26 Medtronic, Inc. Implantable medical device structures including recharge and/or telemetry coil
US20230158302A1 (en) * 2019-09-06 2023-05-25 Nextern, Inc. Systems, Devices, Components and Methods for the Delivery of Electrical Stimulation to Cranial Nerves to Treat Mood or Mood Affective Disorders
KR20210129588A (ko) * 2020-04-20 2021-10-28 인천대학교 산학협력단 주사기 주입형 뇌 신호 측정 및 자극용 구조체 및 이의 주사기 주입 방법

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