WO2025108387A1 - Atomization liquid, atomization liquid preparation method, and electronic atomization device - Google Patents

Abstract

Embodiments of the present application provide an atomization liquid. The atomization liquid comprises: nicotine, cytisine and a solvent. By using cytisine that acts synergistically with nicotine, the atomization liquid that provides better satisfaction and has a better tobacco addiction relief effect is provided without increasing the dosage of nicotine.

Description

Atomized liquid, atomized liquid preparation method and electronic atomization device

This application claims priority to a Chinese patent application filed with the China Patent Office on November 24, 2023, with application number 202311586681.X, and invention name “A kind of atomizing liquid, a method for preparing atomizing liquid, and an electronic atomizing device”, all contents of which are incorporated by reference in this application.

Technical Field

The embodiments of the present application relate to the field of aerosol liquid, and in particular to an aerosol liquid containing nicotine and cytisine.

Background Art

As a substitute for traditional cigarettes, e-cigarettes contain the physiologically active substance nicotine in their aerosol liquid. Users inhale nicotine by smoking e-cigarettes, thereby creating a physiological satisfaction similar to that of smoking traditional cigarettes.

Based on local regulatory policies, limits have been set on the nicotine content in electronic cigarette atomizers. For example, the EU stipulates that the nicotine content in electronic cigarette oil shall not exceed 20 mg/ml. Therefore, compared with traditional cigarettes, the existing electronic cigarette atomizers are still not very ideal in terms of relieving smoking addiction. The vast majority of traditional cigarette consumers reflect that electronic cigarettes cannot give them a better or similar sense of satisfaction than traditional cigarettes, and cannot provide sufficient strength and a fast and lasting nicotine intake experience, resulting in a low conversion rate of traditional tobacco consumers to new electronic cigarette consumers. Therefore, under the premise of meeting the nicotine content limit, providing an electronic cigarette atomizer with a good smoking experience and addiction relief, so as to be comparable to the nicotine intake satisfaction of traditional cigarettes, has become a technical problem that needs to be solved in this field.

Summary of the invention

In order to provide an electronic cigarette atomizing liquid with good smoking experience and addiction relief, an embodiment of the present application provides an atomizing liquid, and the atomizing liquid includes: nicotine, cytisine and a solvent.

In the atomized liquid provided in one embodiment of the present application, the mass fraction of nicotine in the atomized liquid is 0.50%-3.00%.

In the atomized liquid provided in one embodiment of the present application, the mass fraction of cytisine is 0.50%-5.00%.

In the atomized liquid provided in one embodiment of the present application, the mass fraction of the solvent is 50.00%-99.90%.

In the aerosol liquid provided in one embodiment of the present application, the mass fraction of nicotine is 1.00%-2.00%.

In the atomized liquid provided in one embodiment of the present application, the mass fraction of cytisine is 1.00%-4.00%.

In the atomized liquid provided in one embodiment of the present application, cytisine includes the free base of cytisine.

In the atomized liquid provided in one embodiment of the present application, cytisine includes cytisine salt.

In the atomized liquid provided in one embodiment of the present application, the cytisine salt is generated by the reaction of cytisine with an organic acid, and the organic acid is selected from one or a combination of formic acid, acetic acid, propionic acid, butyric acid, α-furanic acid, α-furanylbutyric acid, isovaleric acid, β-methylvaleric acid, levulinic acid, lactic acid, citric acid, malic acid, tartaric acid, succinic acid, oxalic acid, maleic acid, glycolic acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, benzoic acid, phenylacetic acid, caffeic acid, coumaric acid, phthalic acid and terephthalic acid.

The atomized liquid provided in one embodiment of the present application further includes a sweetener, and the mass fraction of the sweetener is 0.01%-0.60%.

In the atomized liquid provided in one embodiment of the present application, the sweetener includes one or a combination of neotame, cyclamate, sucralose, aspartame, steviol glycosides, acesulfame potassium and mogroside.

The atomized liquid provided in one embodiment of the present application further includes a cooling agent, and the mass fraction of the cooling agent is 0.10%-8.00%.

In the atomized liquid provided in one embodiment of the present application, the cooling agent includes one or a combination of menthol, menthone, isomenthone, 2-isopropyl-N,2,3-trimethylbutyramide, N-ethyl-p-menthyl-3-carboxamide and N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide.

The atomized liquid provided in one embodiment of the present application further includes a flavor composition, and the mass fraction of the flavor composition is 1.00%-20.00%.

In the atomizing liquid provided in one embodiment of the present application, the solvent includes one or a mixture of several of propylene glycol, butylene glycol, 1,2,4-butanetriol, dipropylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol 200, polyethylene glycol 400, triacetin, glycerol, dipropylene glycol ether, ethanol, water, triethyl citrate and caprylic acid glyceride.

An embodiment of the present application also provides a method for preparing an atomized liquid, comprising:

Weigh nicotine, cytisine and solvent according to a certain weight ratio;

adding cytisine to the solvent, stirring, and dissolving to obtain a first mixture;

adding nicotine to the first mixture and stirring to obtain a second mixture;

The second mixture was filtered to obtain a nebulized liquid.

In a method for preparing an atomized liquid provided in an embodiment of the present application, in the process of adding cytisine to a solvent, stirring, and dissolving to obtain a first mixture, a sweetener and a cooling agent are also added to the solution.

In a method for preparing an atomized liquid provided in one embodiment of the present application, in the process of adding nicotine to a first mixture and stirring to obtain a second mixture, a flavor composition is also added to the first mixture.

An embodiment of the present application further provides an electronic atomization device, comprising the atomizing liquid provided in the above embodiment and an atomizer, wherein the atomizer is used to heat and atomize the atomizing liquid to generate an aerosol.

The present application provides an atomizing liquid, a preparation method of the atomizing liquid, and an electronic atomizing device, using cytisine which has a synergistic effect with nicotine to provide an atomizing liquid with better satisfaction and better effect of relieving smoking addiction without increasing the amount of nicotine.

BRIEF DESCRIPTION OF THE DRAWINGS

One or more embodiments are exemplarily described by pictures in the corresponding drawings, and these exemplified descriptions do not constitute limitations on the embodiments. Elements with the same reference numerals in the drawings represent similar elements, and unless otherwise stated, the figures in the drawings do not constitute proportional limitations.

FIG1 is a comparison chart of addiction relief scores of Examples 1-3 and Comparative Example 1 of the present application;

FIG2 is a comparison chart of addiction relief scores of Examples 4-6 and Comparative Example 2 of the present application;

FIG3 is a comparison chart of addiction relief scores of Example 7 and Comparative Example 3 of the present application;

FIG4 is a comparison chart of addiction relief scores of Example 8 and Comparative Example 4 of the present application;

FIG5 is a comparison chart of addiction relief scores of Examples 9-11 of the present application and Comparative Example 5.

DETAILED DESCRIPTION

In order to facilitate the understanding of the present application, the present application is described in more detail below in conjunction with the accompanying drawings and specific implementation methods.

Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present application.

Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

An embodiment of the present application provides an atomized liquid, which includes nicotine, cytisine, and a solvent. Cytisine, which has a synergistic effect with nicotine, is used to provide an atomized liquid with a better sense of satisfaction and a better effect of relieving smoking addiction without increasing the amount of nicotine.

In one embodiment of the present application, the mass fraction of nicotine in the atomized liquid is 0.50%-3.00%.

In one embodiment of the present application, the mass fraction of cytisine is 0.50%-5.00%.

In one embodiment of the present application, the mass fraction of the solvent is 50.00%-99.90%.

Nicotine is an important component of e-cigarette liquid. Nicotine can exist in free base form or salt form. Early e-cigarettes generally used nicotine free base. The volatile nicotine free base is more irritating and has a strong throat hit. It is mainly absorbed through the mouth and throat and is difficult to enter the lungs, resulting in a small amount entering the lungs, so the experience is poor. The use of nicotine salts has allowed e-cigarettes to develop further. Since nicotine salts are less volatile and cause less throat irritation, the smoke becomes smoother after using nicotine salts, and more aerosols enter the lungs to participate in lung absorption, thereby improving the experience of e-cigarettes.

The molecular formula of cytisine is C ₁₁ H ₁₄ N _2O . Its Chinese aliases are wild indigo alkaloids and urocanthine. It is a natural bioactive compound. It was first isolated from the golden chain flower of the genus Cytisus by Husemann and Marme in 1865. It mainly exists in plants of the genus Sophora, genus Cassia or Berberidaceae of the Leguminosae family, such as cytisine, Sophora flavescens, and Sophora alopecuroides. It has a high affinity for neuronal nicotinic acetylcholine receptors and is specific to the α-subtype. It is a partial agonist of nicotinic acetylcholine receptors. Modern studies have shown that cytisine has a variety of pharmacological effects, such as smoking cessation, enhancing myocardial contractility, stimulating breathing, anti-depression, dopamine neurotransmission, enhancing motor ability, improving cognitive function, analgesia, and anti-tumor. Although cytisine was isolated only more than a hundred years ago, its history of use in medicine can be traced back thousands of years ago. Indians used cytisine seeds to induce vomiting and laxative effects. In Europe, traditional medicine uses alcohol extracts containing cytisine to treat constipation, migraine, insomnia, cough and neuralgia. About 100 years ago, people used it as an antiasthmatic and insecticide. By 1964, cytisine was developed into a smoking cessation drug and widely sold in Central and Eastern Europe. Clinical studies have proven that the drug has good efficacy and safety. During World War II, when tobacco was in short supply, broom leaves were used by Russian soldiers to smoke as a tobacco substitute. Studies have shown that cytisine has a high affinity for the α broom subtype of the nicotinic acetylcholine receptor and is a low nonspecific partial agonist.

The purpose of the present application is to utilize the synergistic effect of cytisine, a partial agonist of nicotine acetylcholine, on nicotine, so that the electronic cigarette liquid has better suction satisfaction and higher addiction relief without increasing the amount of nicotine, so as to better meet the needs of consumers who have a substitute for smoking; utilize cytisine to partially replace nicotine to achieve a synergistic and synergistic comprehensive experience, reduce the amount of nicotine, and use a low dose of nicotine electronic atomization liquid to achieve the satisfaction of the usual dose (20mg/ml) of electronic atomization liquid on the market, thereby reducing the exposure to nicotine, further reducing the addictiveness and health hazard risks of electronic cigarettes, and making electronic cigarettes a more effective substitute for smoking and smoking cessation tools.

The components of the atomized liquid in some embodiments and comparative examples of the present application are shown in Tables 1-2. The components of the atomized liquid in Tables 1 and 2 are all calculated based on mass fractions.

The above-mentioned embodiments and comparative examples were loaded into the same electronic atomizer, and professional smokers conducted a comprehensive sensory quality evaluation from multiple dimensions, including the amount of atomized smoke, aroma quality, sweetness, coolness, irritation, feeling of being in the head, and sustained effect. Among them, irritation, feeling of being in the head, and sustained effect are related to the addiction relief degree of the atomized liquid. The specific evaluation indicators are shown in Table 3.

Table 1 Components of the atomized liquid in each embodiment and comparative example

Table 2 Components of the atomized liquid in each embodiment and comparative example

Table 3 Comprehensive sensory evaluation index of atomized liquid

According to the above sensory evaluation standard, 7 professional tasters conducted sensory evaluation on the above embodiments and comparative examples. Each sample was evaluated 3 times, and the results were averaged. The obtained scores are shown in Table 4.

Table 4 Sensory evaluation of the atomized liquid in each embodiment and comparative example

As shown in Figures 1-5, in Comparative Example 1 and Examples 1-3, the mass fraction of nicotine is 1.80%, the mass fraction of cytisine increases from 0 to 3.00%, and 15.00% mango flavor is added to the flavor composition. It can be seen that in the mango-flavored atomized liquid, as the mass fraction of cytisine increases, the addiction relief of the atomized liquid is significantly improved. In Comparative Example 2 and Examples 4-6, the mass fraction of nicotine is 1.60%, the mass fraction of cytisine increases from 0 to 2.80%, and the flavor composition is 2.00% tobacco extract and 12.00% tobacco flavor. It can be seen that in the tobacco-flavored atomized liquid, as the mass fraction of cytisine increases, the addiction relief of the atomized liquid is significantly improved. In Example 7 and Comparative Example 3, the mass fraction of nicotine is 3.00%, the mass fraction of cytisine increases from 0 to 2.50%, and the flavor composition is blueberry flavor. It can be seen that in the blueberry flavored atomized liquid, as the mass fraction of cytisine increases, the addiction relief of the atomized liquid is significantly improved. In Comparative Example 4 and Example 8, the mass fraction of nicotine is 0.50%, the mass fraction of cytisine increases from 0 to 5.00%, and the flavor composition is 13.00% grape flavor. It can be seen that in the grape flavored atomized liquid, as the mass fraction of cytisine increases, the addiction relief of the atomized liquid is significantly improved. In Comparative Example 5 and Examples 9-11, the mass fraction of nicotine was reduced from 2.00% to 1.00%, and the mass fraction of cytisine was increased from 0 to 4.00%. The addiction relief degree of the atomized liquid can still be maintained at a certain level. It can be seen that increasing the cytisine content while reducing the nicotine content and replacing part of the nicotine with cytisine can achieve a synergistic and comprehensive experience.

It can be seen from Table 3 that when the mass fraction of nicotine in Example 8 is 0.50%, the scores of irritation, head feeling, and sustained effect of the atomized liquid are 2.86, 2.71, and 2.07, respectively. The mass fraction of nicotine in Example 11 is 1.00%, and the scores of irritation, head feeling, and sustained effect of the atomized liquid are 4.25, 3.32, and 3.12, respectively, and the addiction relief degree of the atomized liquid is greatly improved. And the EU stipulates that the nicotine content in electronic cigarettes is less than 2.00%. Therefore, in some embodiments of the present application, the mass fraction of nicotine in the atomized liquid is 1.00%-2.00%, and the addiction relief degree of the atomized liquid is relatively high.

In some embodiments of the present application, the mass fraction of cytisine is 1.00%-5.00%. When the mass fraction of cytisine is within this range, when the mass fraction of nicotine remains unchanged, the mass fraction of cytisine increases, and the addiction relief degree of the atomized liquid is significantly improved. Therefore, in terms of improving the addiction relief degree, cytisine and nicotine have a synergistic effect.

In some embodiments of the present application, the mass fraction of cytisine is 1.00%-4.00%. Referring to Comparative Example 5 and Examples 9-11, when the mass fraction of nicotine is 1.00%-2.00%, the mass fraction of nicotine is reduced, and cytisine is used to replace part of the nicotine. At this time, the mass fraction of cytisine is 1.00%-4.00%, which can maintain the addiction-relieving degree of the atomized liquid at a certain level. That is, cytisine can be used to partially replace nicotine to achieve a synergistic and comprehensive experience, reduce the amount of nicotine, and use a low dose of nicotine electronic atomization liquid to achieve the satisfaction of the usual dose (20mg/ml) of electronic atomization liquid on the market, thereby reducing the exposure to nicotine, further reducing the addictiveness and health hazard risks of electronic cigarettes, and making electronic cigarettes a more effective smoking cessation tool.

In some embodiments of the present application, the mass fraction of cytisine is 1.00%-3.00%. Referring to Comparative Example 1 and Examples 1-3, when nicotine is at a preset value, the addiction relief degree of the atomized liquid is significantly improved during the process of increasing the mass fraction of cytisine from 1.00% to 3.00%, and the synergistic effect of cytisine and nicotine on addiction relief is relatively significant.

In some embodiments of the present application, cytisine includes the free base of cytisine.

In some embodiments of the present application, cytisine includes cytisine salts.

In some embodiments of the present application, the cytisine salt is generated by reacting cytisine with an organic acid, and the organic acid is selected from one or a combination of formic acid, acetic acid, propionic acid, butyric acid, α-furanic acid, α-furanomethylbutyric acid, isovaleric acid, β-methylvaleric acid, levulinic acid, lactic acid, citric acid, malic acid, tartaric acid, succinic acid, oxalic acid, maleic acid, glycolic acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, benzoic acid, phenylacetic acid, caffeic acid, coumaric acid, phthalic acid and terephthalic acid.

In some embodiments of the present application, the atomized liquid further includes a sweetener, and the mass fraction of the sweetener is 0.01%-0.60%.

In some embodiments of the present application, the sweetener includes one or a combination of neotame, cyclamate, sucralose, aspartame, steviol glycosides, acesulfame potassium and mogroside.

In some embodiments of the present application, the atomized liquid further includes a cooling agent, and the mass fraction of the cooling agent is 0.10%-8.00%.

In some embodiments of the present application, the cooling agent includes one or a combination of menthol, menthone, isomenthone, WS-23 (2-isopropyl-N,2,3-trimethylbutyramide), WS-3 (N-ethyl-p-menthyl-3-carboxamide) and WS-5 (N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide).

In some embodiments of the present application, the atomized liquid further includes a flavor composition, and the mass fraction of the flavor composition is 1.00%-20.00%.

In some embodiments of the present application, the atomized liquid further includes a flavor composition, and the mass fraction of the flavor composition is 10.00%-15.00%.

In some embodiments of the present application, the solvent includes one or a mixture of several of propylene glycol, butylene glycol, 1,2,4-butanetriol, dipropylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol 200, polyethylene glycol 400, triacetin, glycerol, dipropylene glycol ether, ethanol, water, triethyl citrate and caprylic acid glyceride.

In some embodiments of the present application, the added amounts of sweeteners, cooling agents and flavor compositions can be determined according to user needs and are not limited to the contents and types provided in this specification.

An embodiment of the present application also provides a method for preparing an atomized liquid, comprising:

Weigh nicotine, cytisine and solvent according to a certain weight ratio;

adding cytisine to the solvent, stirring, and dissolving to obtain a first mixture;

adding nicotine to the first mixture and stirring to obtain a second mixture;

The second mixture was filtered to obtain a nebulized liquid.

In some embodiments of the present application, in the process of adding cytisine to a solvent, stirring, and dissolving to obtain a first mixture, a sweetener and a cooling agent are also added to the solution.

In some embodiments of the present application, the process of adding nicotine to the first mixture and stirring to obtain the second mixture also includes adding a flavor composition to the first mixture.

In some embodiments of the present application, in the process of filtering the second mixture to obtain the atomized liquid, 80-120 mesh filter cloth is used for filtration.

In some embodiments of the present application, a method for preparing an atomized liquid is provided, comprising:

Weigh nicotine, cytisine, a sweetener, a cooling agent, a flavor composition and a solvent according to a certain weight ratio;

Adding a sweetener, a cooling agent, and cytisine into a solvent, stirring, and dissolving to obtain a first mixture;

adding nicotine and flavor composition to the first mixture and stirring to obtain a second mixture;

The second mixture was filtered through a filter cloth having a mesh size of 80 to 120 to obtain an atomized liquid.

One embodiment of the present application further provides an electronic atomization device, comprising the atomizing liquid and an atomizer provided in the above embodiment, the atomizer being used to atomize the atomizing liquid to generate an aerosol. In some examples, the atomizer may use a heating element using resistance heating, electromagnetic induction heating, infrared radiation heating, or microwave heating; in other examples, the atomizer may use a high-frequency vibration element to atomize the atomizing liquid to form aerosol particles, such as an ultrasonic atomizer.

It should be noted that the preferred embodiments of the present application are given in the specification and drawings of the present application, but are not limited to the embodiments described in the specification. Furthermore, it is possible for a person of ordinary skill in the art to make improvements or changes based on the above description, and all such improvements and changes should fall within the scope of protection of the claims attached to the present application.

Claims (19)

An atomized liquid, characterized in that the atomized liquid comprises: nicotine, cytisine and a solvent. The atomized liquid according to claim 1, characterized in that the mass fraction of nicotine in the atomized liquid is 0.50%-3.00%. The atomized liquid according to claim 1, characterized in that the mass fraction of cytisine is 0.50%-5.00%. The atomized liquid according to claim 1, characterized in that the mass fraction of the solvent is 50.00%-99.90%. The atomized liquid according to claim 1, characterized in that the mass fraction of nicotine is 1.00%-2.00%. The atomized liquid according to claim 1, characterized in that the mass fraction of cytisine is 1.00%-4.00%. The atomized liquid according to claim 1, characterized in that the cytisine comprises a free base of cytisine. The atomized liquid according to claim 1, characterized in that the cytisine comprises a cytisine salt. The atomized liquid according to claim 8, characterized in that the cytisine salt is generated by the reaction of cytisine with an organic acid, and the organic acid is selected from one or a combination of formic acid, acetic acid, propionic acid, butyric acid, α-furanoic acid, α-furanomethylbutyric acid, isovaleric acid, β-methylvaleric acid, levulinic acid, lactic acid, citric acid, malic acid, tartaric acid, succinic acid, oxalic acid, maleic acid, glycolic acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, benzoic acid, phenylacetic acid, caffeic acid, coumaric acid, phthalic acid and terephthalic acid. The atomized liquid according to claim 1, further comprising a sweetener, wherein the mass fraction of the sweetener is 0.01%-0.60%. The atomized liquid according to claim 10, characterized in that the sweetener comprises one or a combination of neotame, cyclamate, sucralose, aspartame, steviol glycosides, acesulfame potassium and mogroside. The atomized liquid according to claim 1 is characterized in that it also includes a cooling agent, and the mass fraction of the cooling agent is 0.10%-8.00%. The atomized liquid according to claim 12, characterized in that the cooling agent comprises one or a combination of menthol, menthone, isomenthone, 2-isopropyl-N,2,3-trimethylbutyramide, N-ethyl-p-menthyl-3-carboxamide and N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide. The atomized liquid according to claim 1, further comprising a flavor composition, wherein the mass fraction of the flavor composition is 1.00%-20.00%. The atomizing liquid according to claim 1, characterized in that the solvent comprises one or a mixture of propylene glycol, butylene glycol, 1,2,4-butanetriol, dipropylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol 200, polyethylene glycol 400, triacetin, glycerol, dipropylene glycol ether, ethanol, water, triethyl citrate and caprylic acid glyceride. A method for preparing an atomized liquid, comprising: Weigh nicotine, cytisine and solvent according to a certain weight ratio; Adding the cytisine to the solvent, stirring, and dissolving to obtain a first mixture; adding the nicotine to the first mixture and stirring to obtain a second mixture; The second mixture is filtered to obtain the atomized liquid. The atomized liquid according to claim 16 is characterized in that, in the process of adding the cytisine to the solvent, stirring, and dissolving to obtain the first mixture, a sweetener and a cooling agent are also added to the solution. The atomized liquid according to claim 16, characterized in that, in the process of adding the nicotine to the first mixture and stirring to obtain the second mixture, a flavor composition is also added to the first mixture. An electronic atomization device comprises an atomizer and an atomizing liquid as described in any one of claims 1 to 15, wherein the atomizer is used to atomize the atomizing liquid to generate an aerosol.