WO2025104540A1

WO2025104540A1 - Stable agrochemical composition

Info

Publication number: WO2025104540A1
Application number: PCT/IB2024/060899
Authority: WO
Inventors: Sujata Vishwas JADHAV; Manishkumar Dagulal Hivare
Original assignee: UPL Ltd
Current assignee: UPL Ltd
Priority date: 2023-11-17
Filing date: 2024-11-05
Publication date: 2025-05-22
Anticipated expiration: 2026-05-17

Abstract

The present disclosure discloses an agrochemical composition of pymetrozine, dinotefuran and an anionic surfactant and a process for preparation thereof. The present invention also provides a method for preventing and controlling rice pests using present agrochemical composition.

Description

TITLE: STABLE AGROCHEMICAL COMPOSITION

Field of invention

The present disclosure relates to an agrochemical composition and in particular, a stable agrochemical composition of neonicotinoids insecticide and process for preparation thereof. The present invention also relates to a method for preventing and controlling rice pests using present agrochemical composition.

Background of the disclosure

Rice plant-hopper (RPH) (Nilaparvata lugens, Sogatella furcifera, and Laodelphax striatellus) infestation is considered one of the most serious disasters in rice production in Asia. RPHs obtain their nutrition by sucking sap from rice plant stems, and RPH feeding causes significantly lowered water content, chlorophyll content, leaf area, dry weight, aerial growth, and consequently the photosynthetic rate of plant. Therefore, RPH infestation is considered one of the most serious disasters in rice production in Asia.

Methods of controlling or eradicating these pests are desirable in many instances, more so when the crops are of commercial interest. Many insecticidal agents and compositions are commercially available for these purposes. Systemic insecticides are specifically those that target insects. Some of the most commonly used systemic insecticides are neonicotinoids. Combination of insecticides are used to broaden the spectrum of control, reduce the number of applications, reduce dosage, thereby reducing environmental impact, decreasing chances of development of resistance.

Dinotefuran is a nicotinic insecticide, which blocks normal conduction of the central nervous system of insects by selectively controlling nicotinic acetylcholinesterase receptors of the insect nervous system, thereby causing paralysis of pests and death. Dinotefuran has the characteristics of contact killing, stomach toxicity, root systemic property, quick effect, long lasting period (3-4 weeks, 43 days of theoretical persistence), wide insecticidal spectrum, has control effect on pests with sucking mouth parts, shows insecticidal activity and has the effect of permeating from the leaf surface to the leaf interior. Dinotefuran is mainly used for preventing and controlling aphids, leafhoppers, plant hoppers, thrips, whiteflies and resistant strains thereof on various crops such as wheat, rice, cotton, vegetables, fruit trees, tobacco leaves and the like.

Pymetrozine, chemical name, 4,5-dihydro-6-methyl-4-(3-pyridine methylene amino)- 1,2, 4-3 (2H)-one belongs to a pyridine azomethine chemical class of insecticides with a remarkable selectivity for plant-sucking insects, such as aphids, whiteflies and plant hoppers, due to its systemic action.

Further, physico-chemical stability of agrochemical compositions is the biggest concern while formulating. Selecting suitable surfactants is critical to achieve physically and chemically stable formulation with appropriate shelf life. Therefore, it is highly desirable to develop a formulation which is stable over long periods of time, does not deteriorate under severe storage conditions, being less phytotoxic to plants and are environmentally friendlier than conventional formulations.

A water dispersible granular (WDG) formulation is a solid formulation that generally incorporates the active ingredient into a granule which disperses or dissolves quickly when added to water in the spray tank to give a fine particle suspension. WDG formulations provide a system for delivering active ingredients to their target and allow for the production of highly concentrated formulations which are wettable and readily disintegrate on contact with water. These types of formulations present advantages in terms of storage as well as in terms of handling and toxicity.

Thus, a need remains in the art for stable formulations with good dispersibility and suspensibility. There also exists the need to provide knock-down activity with prolonged control, that is, fast action with long lasting action.

Therefore, present invention provides a water dispersible granules composition which is stable and provides desired control of rice insects.

Summary of invention

In an aspect, the present disclosure provides a stable agrochemical composition comprising a pyridine azomethine derivative and a neonicotinoid.

In another aspect the present disclosure provides a solid agrochemical composition comprising a pyridine azomethine derivative and a neonicotinoid useful in controlling insects and increasing the plant yield.

In another aspect, the present disclosure provides a water dispersible granule composition comprising: a) a pyridine azomethine derivative b) a neonicotinoid and c) an anionic surfactant.

In another aspect, the present disclosure provides a water dispersible granule composition comprising: a) py metrozine; b) dinotefuran; and c) an anionic surfactant. Yet another aspect of the present disclosure provides a process of preparing stable agrochemical composition comprising a pyridine azomethine derivative and a neonicotinoid insecticide.

Still another aspect of the present disclosure is to provide method of controlling insect infestation using present agrochemical composition comprising a pyridine azomethine derivative and a neonicotinoid insecticide.

Detailed description of invention

The present disclosure now will be described hereinafter with reference to the accompanying examples, in which embodiments of the disclosure are shown. This description is not intended to be a detailed catalogue of all the different ways in which the disclosure may be implemented, or all the features that may be added to the instant disclosure. For example, features illustrated with respect to one embodiment may be incorporated into other embodiments, and features illustrated with respect to a particular embodiment may be deleted from that embodiment. Thus, the disclosure contemplates that in some embodiments of the disclosure, any feature or combination of features set forth herein can be excluded or omitted. In addition, numerous variations and additions to the various embodiments suggested herein will be apparent to those skilled in the art in light of the instant disclosure, which do not depart from the instant disclosure. Hence, the following descriptions are intended to illustrate some particular embodiments of the disclosure, and not to exhaustively specify all permutations, combinations and variations thereof.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the disclosure, suitable methods and materials are described herein. Recitation of ranges of values are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate value is incorporated into the specification as if it were individually recited herein. The endpoints of all ranges are included within the range and independently combinable. As used herein, all numerical values or numerical ranges include integers within such ranges and fractions of the values or the integers within ranges unless the context clearly indicates otherwise. Thus, for example, reference to a range of 90-100%, includes 91%, 92%, 93%, 94%, 95%, 95%, 97%, etc., as well as 91.1%, 91.2%, 91.3%, 91.4%, 91.5%, etc., 92.1%, 92.2%, 92.3%, 92.4%, 92.5%, etc., and so forth. All methods described herein can be performed in a suitable order unless otherwise indicated herein or otherwise clearly contradicted by context.

The use of the terms “a” and “an” and “the” and similar referents (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. The terms first, second etc. as used herein are not meant to denote any particular ordering, but simply for convenience to denote a plurality of, for example, layers.

The terms “comprising”, “having”, “including”, and “containing” are to be construed as open-ended terms (i.e., meaning “including, but not limited to”) unless otherwise noted. “About” or “approximately” as used herein is inclusive of the stated value and means within an acceptable range of deviation for the particular value as determined by one of ordinary skill in the art, considering the measurement in question and the error associated with measurement of the particular quantity (i.e., the limitations of the measurement system). For example, “about” can mean within one or more standard deviations, or within ± 10% or ± 5% of the stated value.

The use of any and all examples, or exemplary language (e.g., “such as”), is intended merely to better illustrate the invention and does not pose a limitation on the scope of the invention unless otherwise claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the invention as used herein.

While the invention has been described with reference to an exemplary embodiment, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention is not limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but that the invention will include all embodiments falling within the scope of the appended claims. Any combination of the above-described elements in all possible variations thereof is encompassed by the invention unless otherwise indicated herein or otherwise clearly contradicted by context.

The term “control” as it relates to a pest, includes the killing of the pest, as well as protecting a plant, a portion of the plant, or a plant seed from attack or invasion by said pest.

“Cost to benefit ratio (C: B Ratio)” is a ratio used in a cost-benefit analysis to summarize the overall relationship between the relative costs and benefits of a project. C:B ratio is expressed in monetary terms. A C:B ratio of greater than 1 indicates positive monetary returns in comparison to the cost involved to execute a project.

The term “Phytotoxicity” refers to a toxic (negative) effect on the growth of a plant.

The term “suspensibility” refers to the ability of particles to be suspended in a diluent (for example water) without settling. The expression of various quantities in terms of “%” or “% w/w” means the percentage by weight of the total solution or composition unless otherwise specified.

Accordingly, in an aspect, the present disclosure provides a stable agrochemical composition comprising a pyridine azomethine derivative and a neonicotinoid.

In an embodiment, the present disclosure provides a stable solid agrochemical composition comprising: a) a pyridine azomethine derivative b) a neonicotinoid; and c) an anionic surfactant.

In an embodiment the pyridine azomethine derivative is pymetrozine. In an embodiment the neonicotinoid insecticide is dinotefuran.

According to an embodiment of the present disclosure, the stable agrochemical composition comprises from about 30% w/w to about 40% w/w of pymetrozine, based on the total weight of the composition.

According to an embodiment of the present disclosure, the stable agrochemical composition comprises from about 10% w/w to about 15% w/w of dinotefuran, based on the total weight of the composition.

According to an embodiment of the present disclosure, the stable agrochemical composition comprises from about 1% w/w to about 10% w/w of anionic surfactant based on the total weight of the composition.

According to an embodiment of the present disclosure, the stable agrochemical composition comprises from about 36% w/w of the pymetrozine, based on the total weight of the composition. According to an embodiment of the present disclosure, the agrochemical composition comprises from about 11% w/w of the dinotefuran, based on the total weight of the composition.

According to an embodiment of the present disclosure, the anionic surfactants comprises polycarboxylate, salts of polycarboxylate for example sodium polycarboxylate, potassium polycarboxylate, polymeric alkyl or aryl sulfonate such as a sodium alkylnaphthalene sulfonate, sodium naphthalene sulfonate, a sodium alkylnaphthalene sulfonate formaldehyde condensate, calcium lignosulfonate, sodium lignosulfonate, ammonium lignosulfonate, sodium diisopropylnaphthalene sulfonate, sodium salt of an arylsulphonic acid methylene linked condensate, a sodium alkyl naphthalene sulfonate-formaldehyde condensate, or a combination thereof.

In an embodiment of the present disclosure, the anionic surfactants comprise polycarboxylate or salts and alkyl naphthalene sulfonate or salts.

In an embodiment, the anionic surfactant comprises polycarboxylate or salt, alkyl naphthalene sulfonate or salts and sodium lignosulphonate.

According to an embodiment, the present composition comprises three anionic surfactants, consisting of sodium diisopropylnaphthalene sulfonate, sodium polycarboxylate, and sodium lignosulphonate.

In an embodiment, the anionic surfactant comprises 3% w/w of polycarboxylate salt, 3% w/w alkyl naphthalene sulfonate and 8 % w/w sodium lignosulphonate.

In an embodiment, the present composition further comprises an antifoaming agent or a defoamer. In an embodiment, the present composition comprises a defoamer and an agrochemically acceptable excipient.

In accordance with an embodiment, the defoamer or anti-foaming agent is poly siloxane emulsion and present in an amount in the range from 0.01 to 1.0% w/w of the total weight of the composition.

In an embodiment the present composition comprises 0.5% w/w of defoamer.

According to an embodiment of the present disclosure, a stable agrochemical composition comprising: a) 36 % py metrozine b) 11 % dinotefuran c) at least three anionic surfactants and d) a defoamer wherein anionic surfactants, consisting of 3% sodium diisopropylnaphthalene sulfonate, 3% polycarboxylate and 8% sodium lignosulphonate.

According to an embodiment of the present disclosure, a stable agrochemical composition comprising: a) py metrozine; b) dinotefuran; and c) an anionic surfactant wherein anionic surfactant comprising sodium diisopropylnaphthalene sulfonate, potassium polycarboxylate and sodium ligno sulphonate and ratio of the three anionic surfactants is about 3:8:3.

According to an embodiment of the present disclosure, a stable agrochemical composition comprising: a) py metrozine; b) dinotefuran; and c) an anionic surfactant wherein anionic surfactant, consisting of sodium diisopropylnaphthalene sulfonate, sodium poly carboxy late and sodium lignosulphonate and ratio of the three anionic surfactants is about 3:8:3.

According to an embodiment of the present disclosure, a stable agrochemical composition comprising: a) py metrozine; b) dinotefuran; and c) at least three anionic surfactants wherein anionic surfactants, consisting of 3% sodium diisopropylnaphthalene sulfonate, 3% potassium polycarboxylate and 8% sodium lignosulphonate and the ratio between pymetrozine and dinotefuran is 36: 11.

According to an embodiment of the present disclosure, a stable agrochemical composition comprising: e) 36 % pymetrozine f) 11 % dinotefuran g) at least three anionic surfactants and h) a defoamer wherein anionic surfactants, consisting of 3% sodium diisopropylnaphthalene sulfonate, 3% potassium polycarboxylate and 8% sodium lignosulphonate.

According to an embodiment of the present disclosure, a stable agrochemical composition comprising: a) 36 % pymetrozine b) 11 % dinotefuran c) at least three anionic surfactants and d) a defoamer wherein anionic surfactants, consisting of 3% sodium diisopropylnaphthalene sulfonate, 3% sodium polycarboxylate, 8% sodium ligno sulphonate and 3% of defoamer.

According to an embodiment of the present disclosure, a stable agrochemical composition comprising: a) 36 % py metrozine b) 11 % dinotefuran c) at least three anionic surfactants and d) a defoamer wherein anionic surfactants, consisting of 3% sodium diisopropylnaphthalene sulfonate, 3% polycarboxylate, 8% sodium ligno sulphonate and 3% of defoamer.

According to an embodiment of the present disclosure, a stable agrochemical composition comprising: e) 36 % py metrozine f) 11 % dinotefuran g) at least three anionic surfactants and h) a defoamer wherein anionic surfactants, consisting of 3% sodium diisopropylnaphthalene sulfonate, 3% potassium polycarboxylate, 8% sodium ligno sulphonate and 3% of defoamer.

Unless otherwise indicated, the ratios disclosed throughout the specification are weight ratios.

According to an embodiment of the present disclosure, the composition further comprises inert carriers. The inert carriers used in agrochemical formulations are selected from ammonium salts for example sodium sulfate, ammonium sulfate, ammonium phosphate, and ammonium nitrate; and mineral clays such as kaolinite, talc, precipitated silica, hydrous alumino silicate and gypsum or a combination thereof.

According to an embodiment of the present disclosure, the stable agrochemical composition of the present disclosure is formulated as a solid composition. The solid composition comprises, but is not limited to, dust, powder, granules, pellets, tablets, dry flowable, wettable powder, water effervescent granules, water dispersible granules (WDG) and water emulsifiable granules.

It is an objective of the present disclosure is to provide an economically significant insecticide composition, particularly water dispersible granules.

In an embodiment, the stable agrochemical composition of the present disclosure is a Water Dispersible Granules (WDG).

In an embodiment, the stable agrochemical composition of the present disclosure further comprises one or more agrochemically acceptable excipients.

The agrochemically acceptable carriers/excipients can be selected from stabilizers, emetic agents, disintegrating agents, defoamer/antifoaming agents, wetting agents, dispersing agents, binding agents, dye(s), fillers, carriers, surfactants and optionally solid and/or liquid auxiliaries and/or adjuvants such as wetters, adhesives, dispersants or emulsifiers, carriers that may be solid or liquid, antifreeze agent, anticaking agents, pH-regulating agents, preservatives, biocides, and other formulation aids.

Examples of antifoaming or defoamers are employed to stop any unwanted foam generated in the formulation product. The preferred defoamer is selected from the group consisting of silicone-based compounds, alcohols, glycol ethers, mineral spirits, acetylene diols, silicone emulsion, polysiloxanes, organosiloxanes, siloxane glycols, reaction products of silicon dioxide and organosiloxane polymer, polydimethylsiloxanes or polyalkylene glycols alone or in combination.

Examples of thickening agents based on anionic heteropolysaccharides for examples xanthan gum.

Preservatives/biocide used may be benzisothiazolinone or phonols, 2-bromo-2- nitropropane- 1,3 -diol, 5-chloro-2-methyl-4-isothiazolin-3-one & 2 methyl-4- isothiazolin-3 one, Glutaraldehyde, Chloromethylisothiazolinone (CMIT)/Methylisothiazolinone (MIT), 2.2-dibromo-3-nitrilopropioamide (Reputain 20), Natamycin & Nisin, Bronopol/CMIT/MIT.

Suitable colorants (for example in red, blue and green) are, preferably, pigments, which are sparingly soluble in water, and dyes, which are water-soluble. Examples are inorganic coloring agents (for example iron oxide, titanium oxide, and iron hexacyanoferrate) and organic coloring agents (for example alizarin, azo and phthalocyanin coloring agents).

In embodiments, the compositions may further comprise a solvent selected from water, aromatic solvents, a glycol, methyl oleate, aliphatic solvents, and mixtures thereof.

In an embodiment the present insecticide composition is stable and significantly controls the insects.

In an embodiment, the present invention provides a water dispersible granule composition comprising: a) 30% w/w to about 40% w/w of pymetrozine b) 10% w/w to about 15% w/w of dinotefuran and c) an anionic surfactant. In an embodiment, in the present composition pymetrozine and dinotefuran are present in a ratio of 36: 11.

According to an embodiment of the present disclosure, a water dispersible granule composition comprises: about 36 % w/w pymetrozine, about 11 % w/w dinotefuran, about 3 % w/w polycarboxylate or potassium polycarboxylate about 8 % w/w sodium ligno sulfonate, and about 3 % w/w sodium diisopropyl naphthalene sulfonate.

According to an embodiment of the present disclosure, a water dispersible granule composition comprises: about 36 % w/w pymetrozine, about 11 % w/w dinotefuran, about 3 % w/w potassium polycarboxylate, about 8 % sodium lignosulfonate, about 3 % w/w sodium diisopropyl naphthalene sulfonate, and about 0.5 % w/w of a defoamer.

In another embodiment, said composition further comprises at least one agrochemically suitable excipient.

According to an embodiment of the present disclosure, a water dispersible granule composition comprises: about 36 % w/w pymetrozine, about 11 % w/w dinotefuran, about 3 % w/w polycarboxylate or potassium polycarboxylate, about 8 % sodium lignosulfonate, about 3 % w/w sodium diisopropyl naphthalene sulfonate, about 0.5 % w/w of a defoamer, and at least one agrochemically suitable excipient. wherein the composition has a cost: benefit ratio in the range from 1: 1 to 1:5 over conventional formulations.

In an embodiment, the present compositions may further include at least one herbicides, insecticides, miticides, acaricide, fertilizers, plant growth regulators, and biocides.

In another aspect the present invention provides a process for the preparation of the present stable agrochemical compositions.

According to an embodiment of the present disclosure, the process of preparing a stable agrochemical composition comprises:

1) mixing pymetrozine, dinotefuran, at least three anionic surfactants, and an agrochemically acceptable ingredient to obtain premix;

2) milling the premix and preparing a dough using water; and

3) preparing the granules from the dough to obtain the composition.

According to an embodiment of the present disclosure, the combining of the above ingredients to obtain a premix or blend is performed using a suitable blender such as ribbon blender, V-blender, and high intensity plough shear mixer.

According to an embodiment of the present disclosure, grinding of the blend may be performed in any suitable device such as air jet mill, air classifier mill, hammer mill, and/or pin disc mill. Jet mills are shear or pulverizing machines in which the particles to be milled are accelerated by gas flows and pulverized by collision. There are a number of different types of jet mill designs, such as double counterflow (opposing jet) and spiral (pancake) fluid energy mills.

According to an embodiment of the present disclosure, the formation of water dispersible granules is performed by a process including, for example, extrusion, pan granulation, fluidised bed spray granulation, spray drying, or a combination thereof.

According to an embodiment of the present disclosure, the drying of the granules may be performed in any suitable drying equipment such as a fluidised bed drier, a tray drier, and/or a Rotocone vacuum drier.

According to an embodiment of the present disclosure, dried granules are subjected to sieving to remove undersized and oversized granules.

According to an embodiment of the present disclosure, the WDG composition is stable under 14 days storage conditions at ambient temperature.

In an embodiment, the suspensibility of the granules is at least 90 % w/w.

In an embodiment, the suspensibility of the granules is about 95 % w/w.

According to an embodiment of the present disclosure, dispersibility of the granules is about 90 % w/w.

In an embodiment of the present disclosure, the pH of the stable solid agrochemical composition is between 7 to 9.

According to an embodiment the present invention provides use of an agrochemical composition comprising pymetrozine and dinotefuran for controlling rice insects.

In an embodiment the method provides controlling rice insects, preferably planthoppers.

In an embodiment the present water dispersible composition is useful for controlling Brown planthopper (BPH) (Nilaparvatalugens'). In an embodiment the present water dispersible composition is useful for controlling White backed planthopper (WBPH) (Sogatellafurcifera).

In an embodiment the present invention provides use of an agrochemical composition for controlling rice pests wherein the composition comprising about 36 % w/w py metrozine, about 11 % w/w dinotefuran, about 8 % sodium lignosulfonate, about 3 % w/w sodium diisopropyl naphthalene sulfonate, and about 3 % w/w polycarboxylate or potassium polycarboxylate.

According to an embodiment of the present disclosure, a method of controlling rice pests comprising applying an agrochemical composition comprising: a) about 36 % w/w pymetrozine, b) about 11 % w/w dinotefuran.

Wherein the composition has a cost: benefit ratio in the range from 1: 1 to 1:5.

In an embodiment, the cost: benefit ratio is in the range from 1:4 to 1:5.

In an embodiment, the cost: benefit ratio is 1:4.89.

In an embodiment, the cost: benefit ratio is 1:4.43.

The cost: benefit ratio is calculated based on application cost of treatments, crop yield and market price of the product.

In an embodiment, the conventional formulations include but are not limited to SG and WG.

In an embodiment, the method of controlling rice pests comprising applying an agrochemical composition in dosage range of 100 g/ha to 500 g/ha. In another embodiment, dosage of the present composition is in the range of 200 g/ha.

In another embodiment, dosage of the present composition is in the range of 300 g/ha.

In another embodiment, dosage of the present composition is in the range of 400 g/ha.

In another embodiment, dosage of the present composition is in the range of 500 g/ha.

In one embodiment the dosage of the present composition is in the range of 188 g/ha.

In an embodiment, the composition of the present invention exhibits no phyto toxicity on the crop.

In view of the above, it will be seen that the several advantages of the disclosure are achieved, and other advantageous results attained. Although the present disclosure has been disclosed in full, it will be understood that numerous additional modifications and variations could be made thereto without departing from the scope of the disclosure. The embodiments may be combined for better understanding of the disclosure, without departing from the scope of the disclosure.

In another embodiment, alternative or multiple embodiments of the disclosure disclosed herein are not to be construed as limitations. Each embodiment can be referred to and claimed individually or in any combination with other embodiments of the disclosure. One or more embodiments of the disclosure can be included in, or deleted from, the disclosure for reasons of convenience and/or patentability.

It will be understood that the specification and examples are illustrative but not limiting of the present disclosure and that other embodiments within the spirit and scope of the disclosure will suggest themselves to those skilled in the art. Other embodiments can be practiced that are also within the scope of the present disclosure. The following examples illustrate the disclosure, but by no means intend to limit the scope of the disclosure.

EXAMPLES

Example 1

In this example, a WDG formulation Pymetrozine and Dinotefuron is represented in below table.

Process:

Pymetrozine and dinotefuran along with inactive ingredients were combined and blended into a ribbon blender to get a homogenous mixture. The mixture thus obtained was grinded using Air jet mill to achieve the desired particle size and this finely grinded mixture was blended and mixed with required quantity of water and antifoam to form extrudable dough. Dough was passed through extruder to get granules. The extruded granules were dried on fluid bed dryer at a temperature between 50°C to 70°C. The dried granules were passed through sieve to obtain uniform sized granules.

Example 2

This composition was prepared by the process analogous to the process of example 1. Example 3

In this example, a WDG formulation containing 360 g/kg Pymetrozine and 110 g/kg Dinotefuron is represented in below table.

This composition was prepared by the process analogous to the process of example 1.

Storage stability data:

The composition of Examples 1 was prepared as water dispersible granules. These compositions were then tested for stability based on various parameters in ambient conditions, i.e., just after preparation of granules at room temperature and also accelerated heat stability (AHS) conditions, i.e., storage at 54°C for 2 weeks. The stability results in ambient condition and AHS conditions are presented in below table. Further, it is observed that the present composition is stable up to 12 months.

It is evident from the above table that present composition comprising the active ingredients and specific anionic surfactants is stable at tested storage conditions. The suspensibility of Pymetrozine in the water dispersible granule composition was greater than 95% in ambient conditions and greater than 95% under AHS conditions. Similarly, suspensibility of the dinotefuran was also observed to be about 100% in ambient conditions and AHS conditions. Also, the number of inversions was found to be less than 20 in the composition at ambient condition as well as in AHS condition.

Example 5 (Comparative example):

The above comparative composition was prepared by the process as provided in example 1 with the required quantity of ingredients as mentioned in the above table. The stability of the composition (comparative example) was tested and found that this composition has poor stability upon storage and AHS condition. The stability observations under storage conditions are provided herein below.

Storage stability data:

It was observed that the composition was not stable in the absence of specific anionic surfactants that are present in the present composition. It is evident from the above table that suspensibility and dispersibility of this composition is poor and hence does not meet the standard requirements of stability.

Example 6

Bio efficacy trial data

The composition comprising combination of dinotefuran and pymetrozine was tested for its ability to control rice pests Nilaparvatalugens) and WBPH (Sogalellafurcifera) in order to evaluate the efficacy of the compositions. The overall effectiveness of the compositions was compared with an untreated control. The details of the trials are outlined below.

Trial details:

Crop: Rice (Paddy)

Observations: 3 days and 7 days after spray (DAS).

The results of the trial are shown in below table.

(i) Efficacy data:

Table 1

It is evident from the above table that in single spray of treatment 2, BPH population was found reducing about 86.96% to 91.67% as compared to control which was increasingly reduced up to 94.12% to 96.15% after second spray. Similar trend of result was obtained during treatment 3, BPH population was found reducing about 82.67% to 91.67% after single spray as compared to control which was increasingly reduced up to 90.22% to 92.13% after second spray.

Table 2

It is evident from the above table that in single spray of treatment 2, BPH population was found reducing about 89.13 to 93.88% as compared to control which was increasingly reduced up to 93.85% to 95.52% after second spray. Similar trend of result was obtained during treatment 3, BPH population was found reducing about 89.58% to 92.31% after single spray as compared to control which was increasingly reduced up to 93.10% to 95.16% after second spray.

It was found that the present composition indicated maximum control of BPH and WBPH. Therefore, it is concluded that the compositions according to the present disclosure are stable and also very effective in the field.

(ii) Rice Crop Yield data:

Table 3

It is evident from the above tables that the composition of present invention during the first and second season rendering significantly highest yield with 45.95 and 47.16 percent increase in yield over control respectfully. (iii) Cost: Benefit ratio data:

Table 4

Table 5

Market price (Rs/kg or lit): Dinotefuran: 5500, Pymetrozine: 6500 and Dino tefuran+Py metrozine: 4500, Paddy rate/T: Rs 30000, Labour charges: Rs.4500.

The Cost: Benefit ratio was calculated based on application cost of treatments, crop yield and price of the product. It was evident from the below tables that the treatment with present composition of Dinotefuran + Pymetrozine were best treatments in respect of cost benefit ratio that is 1 :4.89 and 1:4.43 in comparison to all other treatments.

Claims

CLAIMS:

1. A water dispersible granule composition comprising: a) 30% w/w to about 40% w/w of pymetrozine b) 10% w/w to about 15% w/w of dinotefuran and c) an anionic surfactant.

2. The composition as claimed in claim 1 wherein pymetrozine and dinotefuran are present in a ratio of 36: 11.

3. The composition as claimed in claim 1 wherein the anionic surfactant is present in an amount from 1% w/w to about 10% w/w of total weight of the composition.

4. The composition as claimed in claim 1 wherein the anionic surfactants is selected from one or more polycarboxylate, salts of polycarboxylate such as sodium polycarboxylate, potassium polycarboxylate, polymeric alkyl or aryl sulfonate such as a sodium alkylnaphthalene sulfonate, sodium naphthalene sulfonate, a sodium alkylnaphthalene sulfonate formaldehyde condensate, calcium ligno sulfonate, sodium lignosulfonate, ammonium lignosulfonate, sodium diisopropylnaphthalene sulfonate, sodium salt of an arylsulphonic acid methylene linked condensate, a sodium alkyl naphthalene sulfonate-formaldehyde condensate, or a combination thereof.

5. The composition as claimed in claim 1 wherein the anionic surfactant comprises poly carboxylate or salt, alkyl naphthalene sulfonate or salts and sodium lignosulphonate.

6. The composition as claimed in claim 1 wherein the anionic surfactant comprises 3% w/w of poly carboxy late salt, 3% w/w alkyl naphthalene sulfonate and 8 % w/w sodium lignosulphonate.

7. The composition as claimed in claim 1 further comprises a defoamer and an agrochemically acceptable excipient.

8. The composition as claimed in claim 7 wherein defoamer is polysiloxane emulsion and present in an amount in the range from 0.01% to 1% w/w of the total weight of the composition.

9. A water dispersible granule composition comprising about 36 % w/w pymetrozine, about 11 % w/w dinotefuran, about 3 % w/w poly carboxy late or poly carboxy late salt about 8 % w/w sodium lignosulfonate, and about 3 % w/w sodium diisopropyl naphthalene sulfonate.

10. A method of controlling rice pests comprising applying a water dispersible granule composition as claimed in claim 1, comprising: a) pymetrozine, and b) dinotefuran. wherein pymetrozine and dinotefuran are present in a ratio of 36: 11.