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WO2025101548A3 - Her2 low quantification method - Google Patents

Her2 low quantification method Download PDF

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Publication number
WO2025101548A3
WO2025101548A3 PCT/US2024/054631 US2024054631W WO2025101548A3 WO 2025101548 A3 WO2025101548 A3 WO 2025101548A3 US 2024054631 W US2024054631 W US 2024054631W WO 2025101548 A3 WO2025101548 A3 WO 2025101548A3
Authority
WO
WIPO (PCT)
Prior art keywords
her2
compositions
disclosed
methods
quantification method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/054631
Other languages
French (fr)
Other versions
WO2025101548A2 (en
Inventor
Malini SATYA
Puja RAVIKUMAR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cepheid
Original Assignee
Cepheid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cepheid filed Critical Cepheid
Publication of WO2025101548A2 publication Critical patent/WO2025101548A2/en
Publication of WO2025101548A3 publication Critical patent/WO2025101548A3/en
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Compositions, methods, and systems for detecting human epidermal growth factor receptor 2 (HER2)-low expression levels in a biological sample are disclosed. Also disclosed are compositions, methods, and systems for distinguishing HER2-low expression from HER2-negative or HER2-positive expression. Compositions for improved RNA recovery during sample preparation steps and detection of nucleic acids in the methods herein are also disclosed.
PCT/US2024/054631 2023-11-08 2024-11-06 Her2 low quantification method Pending WO2025101548A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363597284P 2023-11-08 2023-11-08
US63/597,284 2023-11-08

Publications (2)

Publication Number Publication Date
WO2025101548A2 WO2025101548A2 (en) 2025-05-15
WO2025101548A3 true WO2025101548A3 (en) 2025-07-10

Family

ID=93742604

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/054631 Pending WO2025101548A2 (en) 2023-11-08 2024-11-06 Her2 low quantification method

Country Status (1)

Country Link
WO (1) WO2025101548A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016131875A1 (en) * 2015-02-17 2016-08-25 Biontech Diagnostics Gmbh Methods and kits for the molecular subtyping of bladder cancer
US20170211156A1 (en) * 2013-09-24 2017-07-27 Optipharm Co., Ltd. Quantitative Reverse Transcription Polymerase Chain Reaction Kit for Breast Cancer Drug Screening Test and Early Diagnosis Using Tissue and Blood
US20200340065A1 (en) * 2013-08-19 2020-10-29 Biontech Ag Methods and kits for the molecular subtyping of tumors
US10934591B2 (en) * 2007-10-16 2021-03-02 Ventana Medical Systems, Inc. Grading, staging, and prognosing cancer using osteopontin-c

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US5449602A (en) 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
EP2574617B1 (en) 1996-02-09 2016-04-20 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
WO1997045559A1 (en) 1996-05-29 1997-12-04 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US6312892B1 (en) 1996-07-19 2001-11-06 Cornell Research Foundation, Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US6027998A (en) 1997-12-17 2000-02-22 Advanced Micro Devices, Inc. Method for fully planarized conductive line for a stack gate
US6506594B1 (en) 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6262490B1 (en) 1999-11-05 2001-07-17 Advanced Semiconductor Engineering, Inc. Substrate strip for use in packaging semiconductor chips
EP1313880A2 (en) 2000-05-30 2003-05-28 PE Corporation (NY) Methods for detecting target nucleic acids using coupled ligation and amplification
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
AU2019320825B2 (en) 2018-08-17 2025-09-25 Cepheid Methods and compositions for nucleic acid isolation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10934591B2 (en) * 2007-10-16 2021-03-02 Ventana Medical Systems, Inc. Grading, staging, and prognosing cancer using osteopontin-c
US20200340065A1 (en) * 2013-08-19 2020-10-29 Biontech Ag Methods and kits for the molecular subtyping of tumors
US20170211156A1 (en) * 2013-09-24 2017-07-27 Optipharm Co., Ltd. Quantitative Reverse Transcription Polymerase Chain Reaction Kit for Breast Cancer Drug Screening Test and Early Diagnosis Using Tissue and Blood
WO2016131875A1 (en) * 2015-02-17 2016-08-25 Biontech Diagnostics Gmbh Methods and kits for the molecular subtyping of bladder cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOHMANN KERSTIN ET AL: "RNA extraction from archival formalin-fixed paraffin-embedded tissue: a comparison of manual, semiautomated, and fully automated purification methods", CLINICAL CHEMISTRY, OXFORD UNIVERSITY PRESS, US, vol. 55, no. 9, 1 September 2009 (2009-09-01), pages 1719 - 1727, XP009130062, ISSN: 0009-9147 *
HART VIC ET AL: "HER2-PI9 and HER2-I12: two novel and functionally active splice variants of the oncogene HER2 in breast cancer", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, SPRINGER INTERNATIONAL, BERLIN, DE, vol. 147, no. 10, 16 June 2021 (2021-06-16), pages 2893 - 2912, XP037550485, ISSN: 0171-5216, [retrieved on 20210616], DOI: 10.1007/S00432-021-03689-1 *
NOSKE A ET AL: "Comparison of different approaches for assessment of HER2 expression on protein and mRNA level: prediction of chemotherapy response in the neoadjuvant GeparTrio trial (NCT00544765)", BREAST CANCER RESEARCH AND TREATMENT, KLUWER ACADEMIC PUBLISHERS, BO, vol. 126, no. 1, 29 December 2010 (2010-12-29), pages 109 - 117, XP019876076, ISSN: 1573-7217, DOI: 10.1007/S10549-010-1316-Y *
YEN-CHAO WANG ET AL: "Different mechanisms for resistance to trastuzumab versus lapatinib in HER2- positive breast cancers -- role of estrogen receptor and HER2 reactivation", BREAST CANCER RESEARCH, CURRENT MEDICINE GROUP LTD, GB, vol. 13, no. 6, 28 November 2011 (2011-11-28), pages R121, XP021119741, ISSN: 1465-5411, DOI: 10.1186/BCR3067 *

Also Published As

Publication number Publication date
WO2025101548A2 (en) 2025-05-15

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