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WO2025197347A1 - Cathéter à ballonnet - Google Patents

Cathéter à ballonnet

Info

Publication number
WO2025197347A1
WO2025197347A1 PCT/JP2025/004168 JP2025004168W WO2025197347A1 WO 2025197347 A1 WO2025197347 A1 WO 2025197347A1 JP 2025004168 W JP2025004168 W JP 2025004168W WO 2025197347 A1 WO2025197347 A1 WO 2025197347A1
Authority
WO
WIPO (PCT)
Prior art keywords
balloon
covering material
proximal
group
distal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/JP2025/004168
Other languages
English (en)
Japanese (ja)
Inventor
真弘 小嶋
千菜美 佐古
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of WO2025197347A1 publication Critical patent/WO2025197347A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters

Definitions

  • the present invention relates to a balloon catheter.
  • angioplasty which uses a balloon catheter to expand the narrowed area.
  • Angioplasty is a minimally invasive treatment that does not require open chest surgery like bypass surgery, and is widely performed.
  • Aortic stenosis is a condition in which the aortic valve hardens due to calcification, making it difficult to open and impeding blood flow.
  • Treatment for aortic stenosis can involve open-chest surgery and catheter placement of a biological valve (artificial valve), replacing the hardened aortic valve with a biological valve.
  • Placed bioprosthetic valves deteriorate over time due to calcification, wear, and other factors. When an implanted bioprosthetic valve deteriorates, it must be replaced.
  • One procedure under consideration for replacing a bioprosthetic valve is to apply high pressure to the implanted bioprosthetic valve using a braided balloon catheter or multiple balloon catheters, causing it to deform or break; the valve's lumen is then expanded, and a new bioprosthetic valve is then placed inside the deformed or broken bioprosthetic valve using techniques such as transcatheter aortic valve replacement.
  • Patent Document 1 discloses a catheter characterized by having an expansion means composed of multiple expansion elements, with the walls of the multiple expansion elements combined to form a substantially circular cross section when the expansion means is inflated.
  • Patent Document 2 discloses a balloon catheter having multiple balloon members, with multiple outer balloon members arranged to surround the outer surface of an inner balloon member.
  • Patent Document 3 discloses a balloon catheter having multiple balloons that expand independently without being affected by the other balloons and that are separated and do not come into contact with the other balloons after expansion.
  • Patent Document 4 discloses a device having a perfusion balloon with an internal passage and a balloon arranged in the internal passage of the perfusion balloon.
  • Patent Document 5 discloses a catheter including first, second, and third balloons that can be inflated and deflated independently of each other.
  • the present invention aims to provide a balloon catheter that can capture scattered material such as lime while dilating stenotic areas and deforming or destroying biological valves.
  • a balloon catheter according to an embodiment of the present invention that can solve the above problems is as follows.
  • a balloon group including a plurality of balloons arranged in parallel with each other in the circumferential direction; a covering material disposed radially outward of the balloon group,
  • the balloons constituting the balloon group each have a straight pipe portion, a distal tapered portion located distal to the straight pipe portion, and a proximal tapered portion located proximal to the straight pipe portion,
  • a balloon catheter, wherein the covering material is disposed on at least the proximal tapered portion, but not on the distal tapered portion.
  • the balloon catheter according to [1] wherein the covering material is disposed outside the proximal tapered portion.
  • the covering material is disposed inside the outer balloons located in the proximal tapered portion and outside the inner balloon.
  • the covering material has an opening, The balloon catheter according to any one of [1] to [5], wherein the size of the opening is 75 ⁇ m 2 or more and 31,500 ⁇ m 2 or less.
  • the covering material has an opening, The balloon catheter according to any one of [1] to [6], wherein the opening ratio of the covering material is 15% or more and 30% or less.
  • the covering material includes a braided layer or a film layer and a wire material.
  • the covering material has a cylindrical shape having an inner cavity, The balloon catheter according to any one of [1] to [12], further comprising a tubular member having a lumen communicating with the cavity of the covering material.
  • the covering material has an expanded diameter portion at a distal end of the covering material, the expanded diameter portion having an outer diameter larger than the circumscribing circle of the group of balloons.
  • the catheter further includes a shaft having a longitudinal direction, and a distal end of the covering material is fixed to the balloon group.
  • the balloon catheter according to any one of [1] to [14], wherein the proximal end of the covering material is fixed to the shaft.
  • the covering material is positioned at least on the outside of the proximal tapered portion, but not on the outside of the distal tapered portion, so that when the balloon group is expanded in a biological lumen such as a blood vessel, the covering material can receive blood that flows from the distal side to the proximal side. Therefore, when the balloon group is expanded, the narrowed area is dilated or the biological valve is deformed or destroyed, and scattered material such as lime caused by the dilation of the narrowed area or the deformation or destruction of the biological valve can be captured by the covering material positioned on at least the proximal tapered portion of the balloons that make up the balloon group, making it possible to prevent blood vessel blockage by scattered material.
  • FIG. 1 is an overall view of a balloon catheter according to an embodiment of the present invention.
  • 2 is an enlarged view of a portion of the balloon catheter shown in FIG. 1 where a balloon is disposed.
  • 3 shows a cross-sectional view of the balloon catheter shown in FIG. 1 taken along line III-III.
  • 10 is an enlarged view of a portion of a balloon catheter according to another embodiment of the present invention in which a balloon is disposed.
  • FIG. 1 is an enlarged view of a portion of a balloon catheter according to a different embodiment of the present invention in which a balloon is disposed;
  • 10 is an enlarged view of a portion of a balloon catheter according to yet another embodiment of the present invention, in which a balloon is disposed.
  • FIG. 1 is an overall view of a balloon catheter according to an embodiment of the present invention.
  • 2 is an enlarged view of a portion of the balloon catheter shown in FIG. 1 where a balloon is disposed.
  • 3 shows a cross-sectional view of the balloon catheter shown in
  • a balloon catheter has a balloon group including multiple balloons arranged in parallel with one another in the circumferential direction, and a covering material arranged radially outward of the balloon group.
  • the balloons that make up the balloon group have a straight tube section, a distal tapered section located distal to the straight tube section, and a proximal tapered section located proximal to the straight tube section.
  • the covering material is arranged on at least the proximal tapered section, but not on the distal tapered section.
  • Figure 1 is an overall view of a balloon catheter according to one embodiment of the present invention
  • Figure 2 is an enlarged view of the portion of the balloon catheter shown in Figure 1 where the balloon is located
  • Figure 3 is a cross-sectional view of the balloon catheter shown in Figure 1 taken along line III-III, representing a cross-section perpendicular to the longitudinal direction of the portion where the balloon group is present when the balloon group is in an expanded state.
  • Figure 4 is an enlarged view of the portion of a balloon catheter according to another embodiment of the present invention where the balloon is located
  • Figure 5 is an enlarged view of the portion of a balloon catheter according to a different embodiment of the present invention where the balloon is located
  • Figure 6 is an enlarged view of the portion of a balloon catheter according to yet another different embodiment of the present invention where the balloon is located.
  • the balloon catheter 1 has a balloon group 11 including multiple balloons 10 arranged in parallel with one another in the circumferential direction z, and a covering material 100 arranged radially outward of the balloon group 11.
  • the balloon 10 has a longitudinal direction x, a radial direction y connecting the centroid of the outer edge of the balloon 10 to a point on the outer edge in a cross section perpendicular to the longitudinal direction x, and a circumferential direction z along the outer edge of the balloon 10 in a cross section perpendicular to the longitudinal direction x.
  • the direction toward the user in the longitudinal direction x is referred to as the proximal side
  • the direction opposite the proximal side, i.e., toward the patient being treated is referred to as the distal side.
  • each component or part when each component or part is divided into two equal parts in the longitudinal direction x of the balloon 10, the part of each component or part located on the distal side is referred to as the distal part of each component or part, and the part of each component or part located on the proximal side is referred to as the proximal part of each component or part.
  • the distal end of each component or part is the end located most distally of each component or part.
  • the proximal end of each component or part is the end located most proximal of each component or part.
  • end includes the peripheral portion of the end. That is, the distal end refers to the distal end and the area surrounding the distal end, and the proximal end refers to the proximal end and the area surrounding the proximal end.
  • Components and parts other than the balloon 10 also have longitudinal, radial, and circumferential directions, which may or may not be the same as the longitudinal direction x, radial direction y, and circumferential direction z of the balloon 10. However, for ease of understanding, this specification will be described as assuming that all components and parts have the same longitudinal, radial, and circumferential directions as the longitudinal direction x, radial direction y, and circumferential direction z of the balloon 10.
  • a balloon group 11 having multiple balloons 10 is located at the distal portion of the balloon catheter 1.
  • the balloon 10 can be expanded by introducing fluid into the inner cavity of the balloon 10, and can be deflated by discharging fluid from the inner cavity of the balloon 10.
  • fluid can be introduced or discharged using an indeflator (balloon pressurizer).
  • the fluid can be, for example, saline or a mixture of a contrast agent and saline.
  • the fluid may also be pressurized fluid pressurized by a pump or the like.
  • Examples of materials that can be used to form the balloon 10 include polyamide resins such as nylon 11 and nylon 12, polyester resins such as polyethylene terephthalate and polybutylene terephthalate, polyurethane resins, and thermoplastic elastomers such as polyether block amide copolymers.
  • the balloons 10 constituting the balloon group 11 have a straight tube section 111, a distal tapered section 112 located distal to the straight tube section 111, and a proximal tapered section 113 located proximal to the straight tube section 111. Since the balloon 10 has the straight tube section 111, the distal tapered section 112, and the proximal tapered section 113, it is also preferable that the balloon group 11 has a straight tube section, a distal tapered section located distal to the straight tube section, and a proximal tapered section located proximal to the straight tube section.
  • the straight tube portion 111 is preferably generally cylindrical and has approximately the same diameter in the longitudinal direction x, but may have different diameters in the longitudinal direction x.
  • the distal tapered portion 112 and the proximal tapered portion 113 are preferably formed into a generally conical or truncated conical shape, with diameters decreasing as they move away from the straight tube portion 111. Because the straight tube portion 111 has the largest diameter, when the balloon group 11 is expanded at a lesion such as a stenosis, the straight tube portions of the balloons 10 constituting the balloon group 11 can sufficiently contact the lesion, facilitating treatment such as dilation of the lesion.
  • the distal tapered portion 112 and the proximal tapered portion 113 have reduced diameters, the outer diameters of the proximal and distal ends of the balloons 10 constituting the balloon group 11 can be reduced when the balloon group 11 is deflated, making it easier to insert the balloon catheter 1 into a body cavity.
  • the balloons 10 constituting the balloon group 11 preferably further have a distal sleeve portion 114 located distal to the distal tapered portion 112, and a proximal sleeve portion 115 located proximal to the proximal tapered portion 113.
  • the straight tube portion 111, distal tapered portion 112, and proximal tapered portion 113 are portions that expand when fluid is introduced into the balloon 10, whereas the distal sleeve portion 114 and proximal sleeve portion 115 preferably do not expand.
  • At least a portion of the distal sleeve portion 114 and at least a portion of the proximal sleeve portion 115 can be configured to be easily fixed to other objects, such as the shaft 70 of the balloon catheter 1. Details of the shaft 70 will be described later.
  • the covering material 100 is a component disposed on the balloon group 11.
  • the covering material 100 is disposed on at least the proximal tapered portion 113, but not on the distal tapered portion 112. In other words, the covering material 100 may or may not be disposed on the straight tube portion 111.
  • the covering material 100 is disposed at least on the proximal tapered portion 113, but not on the distal tapered portion 112. This allows the covering material 100 to receive blood flowing from the distal side of the balloon group 11 to the proximal side when the balloon group 11 is inflated in the blood vessel. Therefore, even if scattered material such as lime is scattered when the balloon group 11 is inflated, the scattering material can be captured by the covering material 100, preventing the scattered material from blocking peripheral blood vessels such as the brain.
  • the thickness of the covering material 100 is preferably 10 ⁇ m or more, more preferably 20 ⁇ m or more, and even more preferably 30 ⁇ m or more. By setting the lower limit of the thickness of the covering material 100 within the above range, the balloon 10 is less likely to be damaged even if it comes into contact with the wall of a biological lumen that has hardened due to calcification or the like. Furthermore, the thickness of the covering material 100 is preferably 50 ⁇ m or less, more preferably 70 ⁇ m or less, and even more preferably 100 ⁇ m or less.
  • the covering material 100 can more easily follow the contraction of the balloon 10, its bulkiness in the contracted state can be reduced, and its ability to pass through a biological lumen that has hardened due to calcification or the like can be ensured.
  • the covering material 100 is preferably disposed outside the proximal tapered portion 113.
  • the covering material 100 is preferably disposed outside the proximal tapered portion 113 and not disposed on the distal tapered portion 112.
  • the covering material 100 disposed outside the proximal tapered portion 113 can more easily receive blood flowing from the distal side to the proximal side of the balloon group 11. This makes it easier for the covering material 100 to capture scattered material such as lime dispersed by the expansion of the balloon group 11, thereby improving the effectiveness of preventing blood vessel blockage due to scattered material.
  • the balloon group 11 preferably includes an inner balloon 40 and multiple outer balloons 50 arranged radially outward of the inner balloon 40. That is, the balloon group 11 preferably includes an inner balloon 40 and multiple outer balloons 50 arranged along the outer periphery of the inner balloon 40.
  • the multiple outer balloons 50 suppress the outward expansion of the inner balloon 40
  • the inner balloon 40 suppresses the inward expansion of the multiple outer balloons 50.
  • the inner balloon 40 and the multiple outer balloons 50 mutually suppress their respective expansions, thereby increasing the pressure resistance of the balloon group 11 and increasing the hardness of the multiple balloons 10 constituting the balloon group 11, thereby improving their expansion force.
  • the inner balloon 40 and the multiple outer balloons 50 mutually suppress their respective expansions, making it difficult for the multiple balloons 10 constituting the balloon group 11 to inflate. Therefore, even when high pressure is applied to each of the balloons 10 that make up the balloon group 11, over-expansion of the balloons 10 is suppressed, preventing the balloon group 11 from expanding beyond the intended outer diameter, reducing damage to the aortic valve and other internal lumen of the body and improving safety.
  • the number of inner balloons 40 may be multiple, but is preferably one.
  • the balloon group 11 preferably has one inner balloon 40 and multiple outer balloons 50. Having only one inner balloon 40 makes it less likely for the inner balloon 40 to move inside the multiple outer balloons 50 when the balloon group 11 is inflated. As a result, the inner balloon 40 can more easily suppress the inflation of the multiple outer balloons 50, which increases the hardness of the multiple balloons 10 that make up the balloon group 11 and makes it easier to increase the inflation force.
  • the number of outer balloons 50 included in the balloon group 11 is preferably three or more, more preferably four or more, and even more preferably five or more. Setting the lower limit of the number of outer balloons 50 included in the balloon group 11 within the above range makes it easier for the outer balloons 50 to surround the outer periphery of the inner balloon 40, making it easier for the outer balloons 50 to suppress the expansion of the inner balloon 40. As a result, when fluid is introduced into the lumen of both the inner balloon 40 and the outer balloons 50 to expand the balloon group 11, the inner balloon 40 becomes less likely to expand, increasing the hardness of the inner balloon 40 and making it easier to increase the expansion force of the balloon group 11.
  • the number of outer balloons 50 included in the balloon group 11 is preferably 20 or less, more preferably 12 or less, even more preferably 10 or less, and particularly preferably 8 or less.
  • the outer balloons 50 are less likely to move in the circumferential direction z when the balloon group 11 is inflated, making it easier for the multiple outer balloons 50 to suppress the inflation of the inner balloon 40.
  • the materials listed as materials for constructing the balloon 10 can be used as materials for constructing the inner balloon 40 and the outer balloon 50.
  • the material for constructing the outer balloon 50 may be the same as the material for constructing the inner balloon 40, or it may be different.
  • each of the multiple outer balloons 50 included in the balloon group 11 may be different, but are preferably the same. In other words, it is preferable that the balloon group 11 includes multiple outer balloons 50 made from the same material. By making each of the multiple outer balloons 50 out of the same material, the degree of expansion, hardness, etc. of each of the multiple outer balloons 50 in the circumferential direction z can be made to be approximately the same.
  • the maximum outer diameters of the multiple outer balloons 50 included in the balloon group 11 may be different, but are preferably the same.
  • the multiple outer balloons 50 included in the balloon group 11 having the same maximum outer diameter means that the maximum outer diameters of the multiple outer balloons 50 are approximately the same. Specifically, this means that the maximum outer diameter of one outer balloon 50 is between 90% and 110% of the maximum outer diameters of all the other outer balloons 50.
  • the multiple outer balloons 50 included in the balloon group 11 have the same maximum outer diameter, making it easier to synchronize the expansion timing of all the outer balloons 50 included in the balloon group 11 and to control the expansion of the balloon group 11.
  • the expanded state of the balloon group 11 can be rephrased as when the balloon group 11 is expanded, and refers to a state in which fluid is introduced into the lumen of each of the multiple balloons 10 that make up the balloon group 11, and all of the balloons 10 that make up the balloon group 11 are expanded.
  • the maximum outer diameter of the inner balloon 40 may be the same as or different from the maximum outer diameter of each of the multiple outer balloons 50 included in the balloon group 11.
  • the fact that the maximum outer diameter of the inner balloon 40 is the same as the maximum outer diameter of each of the multiple outer balloons 50 included in the balloon group 11 means that the maximum outer diameter of the inner balloon 40 and the maximum outer diameter of each of the multiple outer balloons 50 included in the balloon group 11 are approximately the same. Specifically, this means that the maximum outer diameter of the inner balloon 40 is between 90% and 110% of the average value of the maximum outer diameters of each of the multiple outer balloons 50.
  • the maximum outer diameter of the inner balloon 40 is the same as the maximum outer diameter of each of the multiple outer balloons 50 included in the balloon group 11, which makes it easier to balance the force that attempts to expand the inner balloon 40 with the force that attempts to suppress the expansion of the inner balloon 40 due to the expansion of the multiple outer balloons 50.
  • the rigidity of the balloon group 11 is increased, making it easier to increase the expansion force of the balloon group 11.
  • the maximum outer diameter of the inner balloon 40 is preferably larger than the maximum outer diameter of the multiple outer balloons 50 included in the balloon group 11.
  • the maximum outer diameter of the inner balloon 40 is larger than the maximum outer diameter of the multiple outer balloons 50 included in the balloon group 11, which makes it easier to evenly arrange the multiple outer balloons 50 along the outer periphery of the expanded inner balloon 40. Therefore, when the balloon group 11 is deflated, the multiple outer balloons 50 are more likely to fold, making it possible to reduce the outer diameter of the balloon catheter 1 at the portion where the balloon group 11 is located.
  • the maximum outer diameter of the inner balloon 40 is preferably 1.10 times or more, more preferably 1.15 times or more, and even more preferably 1.20 times or more, the maximum outer diameter of the multiple outer balloons 50 included in the balloon group 11.
  • the maximum outer diameter of the inner balloon 40 is preferably 3.0 times or less, more preferably 2.5 times or less, and even more preferably 2.0 times or less, the maximum outer diameter of the multiple outer balloons 50 included in the balloon group 11.
  • the length L50 from the distal end 50d of the outer balloon 50 to the proximal end 50p of the outer balloon 50 in the longitudinal direction x of each of the multiple outer balloons 50 included in the balloon group 11 may be different, but is preferably the same.
  • the length L50 from the distal end 50d of the outer balloon 50 to the proximal end 50p of the outer balloon 50 in the longitudinal direction x of each of the multiple outer balloons 50 included in the balloon group 11 being the same means that the length L50 in the longitudinal direction x of each of the multiple outer balloons 50 included in the balloon group 11 is approximately the same; specifically, this means that the length L50 in the longitudinal direction x of one outer balloon 50 is between 90% and 110% of the length L50 in the longitudinal direction x of all the other outer balloons 50.
  • the length L50 in the longitudinal direction x of the multiple outer balloons 50 included in the balloon group 11 is the same, which makes it easier to synchronize the expansion timing of all outer balloons 50 and makes it easier to control the expansion of the balloon group 11.
  • the length L40 from the distal end 40d of the inner balloon 40 to the proximal end 40p of the inner balloon 40 in the longitudinal direction x is preferably shorter than the length L50 from the distal end 50d of the outer balloon 50 to the proximal end 50p of the outer balloon 50 in the longitudinal direction x.
  • the balloon group 11 makes it easier for the balloon group 11 to expand more in areas where the inner balloon 40 is present than in areas where the inner balloon 40 is not present, making it easier to apply pressure to areas where the inner balloon 40 is present, allowing for accurate application of pressure to the desired location. Furthermore, the balloon group 11 is less likely to expand more in areas where the inner balloon 40 is not present, making it more difficult to apply pressure, which reduces the likelihood of stress being placed on areas that are not the desired location, thereby improving the minimally invasive nature of the balloon catheter 1.
  • the length L40 from the distal end 40d of the inner balloon 40 to the proximal end 40p of the inner balloon 40 in the longitudinal direction x is preferably 95% or less, more preferably 90% or less, and even more preferably 85% or less of the length L50 from the distal end 50d of the outer balloon 50 to the proximal end 50p of the outer balloon 50 in the longitudinal direction x.
  • the length L40 from the distal end 40d of the inner balloon 40 to the proximal end 40p of the inner balloon 40 in the longitudinal direction x is preferably at least 20%, more preferably at least 25%, and even more preferably at least 30% of the length L50 from the distal end 50d of the outer balloon 50 to the proximal end 50p of the outer balloon 50 in the longitudinal direction x.
  • the distal end 40d of the inner balloon 40 is located proximal to the distal end 50d of the outer balloon 50, and that the proximal end 40p of the inner balloon 40 is located distal to the proximal end 50p of the outer balloon 50.
  • the distal end 40d of the inner balloon 40 By configuring the distal end 40d of the inner balloon 40 to be proximal to the distal end 50d of the outer balloon 50 and the proximal end 40p of the inner balloon 40 to be distal to the proximal end 50p of the outer balloon 50, the distal end of the inner balloon 40 and the distal end of the outer balloon 50 are less likely to overlap, and the proximal end of the inner balloon 40 and the proximal end of the outer balloon 50 are less likely to overlap. As a result, when the balloon group 11 is in a deflated state, the outer diameter of the portion of the balloon catheter 1 where the balloon group 11 is located can be easily reduced.
  • the distal end of the distal tapered portion of the inner balloon 40 is proximal to the proximal end of the distal tapered portion of the outer balloon 50, and that the proximal end of the proximal tapered portion of the inner balloon 40 is distal to the distal end of the proximal tapered portion of the outer balloon 50.
  • the distal end of the distal tapered portion of the inner balloon 40 is proximal to the proximal end of the distal tapered portion of the outer balloon 50 and the proximal end of the proximal tapered portion of the inner balloon 40 is distal to the distal end of the proximal tapered portion of the outer balloon 50, the positions of the distal tapered portion of the inner balloon 40 and the distal tapered portion of the outer balloon 50 do not overlap, and the positions of the proximal tapered portion of the inner balloon 40 and the proximal tapered portion of the outer balloon 50 do not overlap.
  • the outer diameter of the balloon group 11 is less likely to increase when the balloon group 11 is in an expanded state, making it easier to improve minimal invasiveness.
  • the distance from the distal end 40d of the inner balloon 40 to the distal end 50d of the outer balloon 50 in the longitudinal direction x be approximately the same as the distance from the proximal end 40p of the inner balloon 40 to the proximal end 50p of the outer balloon 50 in the longitudinal direction x. In other words, it is preferable that the distance from the distal end 40d of the inner balloon 40 to the distal end 50d of the outer balloon 50 in the longitudinal direction x be greater than or equal to 90% and less than or equal to 110% of the distance from the proximal end 40p of the inner balloon 40 to the proximal end 50p of the outer balloon 50 in the longitudinal direction x.
  • the inner balloon 40 is more likely to be positioned in the central portion of the balloon group 11 in the longitudinal direction x.
  • the area where the load is applied by expanding the balloon group 11 tends to be the center of the balloon group 11, making it easier to adjust the area where pressure is applied by the balloon group 11.
  • the position of the midpoint of the length L40 from the distal end 40d of the inner balloon 40 to the proximal end 40p of the inner balloon 40 in the longitudinal direction x coincides with the position of the midpoint of the length L50 from the distal end 50d of the outer balloon 50 that constitutes the balloon group 11 to the proximal end 50p of the outer balloon 50 in the longitudinal direction x.
  • the balloon 10 is most likely to expand at the midpoint of the length of the balloon group 11 in the longitudinal direction x, making it easier for the balloon group 11 to apply high pressure to the target area.
  • the balloon group 11 includes a first outer balloon 51 and a second outer balloon 52 adjacent to the first outer balloon 51 on one side of the inner balloon 40 in the circumferential direction z.
  • the first outer balloon 51 and the second outer balloon 52 are preferably in contact with each other. That is, when the balloon group 11 is inflated, the outer surfaces of at least one pair of adjacent outer balloons 50 are preferably in contact with each other. Because the first outer balloon 51 and the second outer balloon 52 are in contact with each other when the balloon group 11 is inflated, when a fluid is introduced into the balloons 10 constituting the balloon group 11 to inflate the balloons 10, the adjacent first outer balloon 51 and second outer balloon 52 mutually suppress the expansion of each other. This increases the pressure of the fluid pumped into the lumen of the first outer balloon 51 and the second outer balloon 52, increasing the hardness of both the first outer balloon 51 and the second outer balloon 52 and increasing the expansion force of the balloon group 11.
  • each outer balloon 50 be in contact with the outer balloons 50 located on both sides of itself in the circumferential direction z.
  • all of the outer balloons 50 that make up the balloon group 11 are in contact with adjacent outer balloons 50.
  • all of the outer balloons 50 that make up the balloon group 11 suppress each other's expansion, and the internal pressure of all of the outer balloons 50 increases. This increases the hardness of the balloon group 11 as a whole, further increasing the expansion force of the balloon group 11.
  • the outer balloon 50 of the balloon group 11 when the balloon group 11 is in an expanded state, preferably contacts the outer peripheral surface of the inner balloon 40. That is, when the balloon group 11 is in an expanded state, it is preferable that at least one of the outer balloons 50 of the balloon group 11 contacts the outer surface of the inner balloon 40. When the balloon group 11 is in an expanded state, the outer balloon 50 of the balloon group 11 contacts the outer peripheral surface of the inner balloon 40, which makes it easier for the inner balloon 40 and the outer balloon 50 to mutually suppress each other's expansion when the balloon group 11 is expanded. As a result, both the inner balloon 40 and the outer balloon 50 are less likely to inflate, which makes it easier to increase the expansion force of the balloon group 11.
  • all of the outer balloons 50 constituting the balloon group 11 are in contact with the outer peripheral surface of the inner balloon 40.
  • all of the outer balloons 50 constituting the balloon group 11 are in contact with the outer peripheral surface of the inner balloon 40, which increases the effect of the inner balloons 40 and the outer balloons 50 suppressing each other's expansion, making it easier to further increase the expansion force of the balloon group 11.
  • the covering material 100 is preferably disposed inside the multiple outer balloons 50 located in the proximal tapered portion 113 and outside the inner balloon 40. That is, the covering material 100 is preferably disposed in the proximal tapered portion 113, radially between the multiple outer balloons 50 and the inner balloon 40, and not disposed in the distal tapered portion 112.
  • the covering material 100 can more easily receive blood flowing from the distal side to the proximal side of the balloon group 11 through the inside of the balloon group 11.
  • the covering material 100 can more easily capture scattered material caused by the expansion of the stenotic area due to the expansion of the balloon group 11 or the deformation or destruction of the biological valve, improving the effectiveness of preventing blood vessel blockage due to scattered material.
  • the dressing 100 preferably has a filter section.
  • a filter is a device with liquid-permeable through-holes that allow liquid to flow from one side of the filter to the other through the through-holes, and has the function of capturing solids larger than the through-holes.
  • the entire dressing 100 may constitute the filter section, or only a portion of the dressing 100 may constitute the filter section. In other words, it is preferable that at least a portion of the dressing 100 is a filter section.
  • the covering material 100 preferably has openings.
  • the openings in the covering material 100 allow blood to pass through the covering material 100 in the blood vessels. This allows blood to perfuse when the balloon group 11 is inflated, improving the minimally invasive nature of the balloon catheter 1.
  • the shape of the opening when viewed from the thickness direction of the covering material 100 can be a polygonal shape such as a triangle, square, or pentagon, a circle, an ellipse, or a combination of these.
  • polygons include polygons with clearly defined corners and straight sides, as well as rounded polygons with rounded corners and polygons with at least some of the sides curved.
  • the dressing 100 has multiple openings. In other words, it is preferable that the dressing 100 has multiple openings. By having multiple openings in the dressing 100, blood can pass through the dressing 100 more easily, facilitating smooth blood perfusion.
  • the size of at least one opening is 75 ⁇ m2 or more and 31,500 ⁇ m2 or less, and it is more preferable that the average area per opening is 75 ⁇ m2 or more and 31,500 ⁇ m2 or less for all openings.
  • the size of the opening is preferably 75 ⁇ m2 or more, more preferably 400 ⁇ m2 or more, even more preferably 1500 ⁇ m2 or more, even more preferably 4000 ⁇ m2 or more, and particularly preferably 7500 ⁇ m2 or more.
  • the size of the opening is preferably 31500 ⁇ m2 or less, more preferably 25000 ⁇ m2 or less, even more preferably 20000 ⁇ m2 or less, even more preferably 15000 ⁇ m2 or less, and particularly preferably 10000 ⁇ m2 or less.
  • the opening rate of the covering material 100 is preferably 15% or more and 30% or less.
  • the opening rate of the covering material 100 refers to the ratio of the total area occupied by the openings in the covering material 100 to the total area of the covering material 100.
  • the opening rate of the dressing 100 is preferably 15% or more, more preferably 17% or more, and even more preferably 19% or more.
  • the opening rate of the dressing 100 is preferably 30% or less, more preferably 28% or less, and even more preferably 26% or less.
  • the proximal end 100p of the dressing 100 is preferably located more proximal than the proximal end 113p of the proximal tapered portion 113.
  • the scattered material captured by the dressing 100 is less likely to detach, making it easier to capture the scattered material efficiently.
  • the distal end 100d of the covering material 100 is preferably located proximal to the proximal end 112p of the distal tapered portion 112 and distal to the distal end 113d of the proximal tapered portion 113.
  • the covering material 100 is disposed not only in the proximal tapered portion 113 but also in at least a portion of the straight tube portion 111. As a result, the area of contact between the covering material 100 and the balloon group 11 is increased, making it easier to firmly fix the covering material 100 to the balloon group 11.
  • the covering material 100 is not disposed on the straight tube portion 111.
  • the distal end 100d of the covering material 100 is located more proximal than the distal end 113d of the proximal tapered portion 113.
  • the dressing material 100 is preferably cylindrical and has an internal cavity.
  • the cylindrical shape of the dressing material 100 makes it easier to capture airborne material in the internal cavity of the dressing material 100, and also makes it more difficult for the captured airborne material to escape outside the dressing material 100.
  • the covering material 100 preferably contains fibers or wires.
  • Specific examples include covering materials 100 that have a braided structure in which fibers or wires are woven, a structure in which fibers or wires are wound in at least one of the longitudinal direction x and the circumferential direction z, or a layered structure that includes fibers or wires.
  • Examples of materials constituting the fibers or wires contained in the covering material 100 include metal wires such as stainless steel, carbon steel, and nickel-titanium alloys, as well as polyamide resins (e.g., nylon), polyolefin resins (e.g., polyethylene and polypropylene), polyester resins (e.g., PET), aromatic polyether ketone resins (e.g., PEEK), polyimide resins, aromatic polyamide resins (e.g., aramid), and fluorine-based resins (e.g., PTFE, PFA, FEP, ETFE).
  • the fibers or wires contained in the covering material 100 may have a monofilament structure or a multifilament structure.
  • the dressing material 100 includes a film-like material.
  • the film-like material may be made of a single material, such as a synthetic resin, or may be made of multiple materials, such as a base material and a filler.
  • Examples of materials that make up the film-like substance or the base material of the film-like substance include polyamide resins, polyester resins, polyurethane resins, polyolefin resins, polyimide resins, fluorine-based resins, vinyl chloride resins, silicone resins, natural rubber, and synthetic rubber.
  • the material that makes up the filler may be an organic material, an inorganic material, or an organic-inorganic composite material.
  • organic materials include thermosetting resins such as phenol, epoxy, and urea, and thermoplastic resins such as polyester, polyvinylidene chloride, polystyrene, and polymethacrylate.
  • inorganic materials include shirasu, perlite, glass, silica, alumina, zirconia, and carbon.
  • the shape of the filler may be, for example, particulate (e.g., spherical), acicular, fibrous, or plate-like.
  • the covering material 100 includes a braided layer or film layer and a wire material.
  • the covering material 100 is configured by combining a braided layer or film layer with a wire material.
  • the wire material acts like a framework and can withstand the force from the blood flow.
  • the wire material increases the rigidity of the braided layer or film material layer, making it easier for the covering material 100 to adhere to the blood vessels, making it easier for the covering material 100 to capture scattered material.
  • the balloon catheter 1 further includes a tubular member 140 with a lumen that communicates with the inner cavity of the dressing material 100.
  • a tubular member 140 with a lumen that communicates with the inner cavity of the dressing material 100 it becomes possible to collect scattered material captured in the inner cavity of the dressing material 100 by the tubular member 140 and to release fluids such as saline through the inner cavity of the dressing material 100, making it easier to perform procedures using the balloon catheter 1.
  • the tubular member 140 is a cylindrical member with a lumen that communicates with the inner cavity of the covering material 100.
  • materials that can be used to form the tubular member 140 include resins such as polyamide resins, polyester resins, polyurethane resins, polyolefin resins, fluorine-based resins, vinyl chloride resins, silicone resins, natural rubber, and synthetic rubber; stainless steels such as SUS304 and SUS316; metals such as platinum, nickel, cobalt, chromium, titanium, tungsten, gold, Ni-Ti alloys, and Co-Cr alloys; and combinations of these.
  • the dressing 100 may have an expanded diameter section 103 at the distal end of the dressing 100, the expanded diameter section 103 having an outer diameter larger than the circumscribing circle of the balloon group 11.
  • the distal end of the dressing 100 has an expanded umbrella-like configuration.
  • the expanded diameter section 103 makes it easier to guide scattered material into the dressing 100, making it more difficult for scattered material to slip through the vicinity of the dressing 100, thereby improving the effectiveness of capturing scattered material.
  • the outer surface of the covering material 100 has a portion that comes into contact with another object.
  • the outer surface of the covering material 100 may come into point contact, line contact, or surface contact with the other object.
  • the outer surface of the dressing 100 may be in contact with other objects only in part of the circumferential direction z, but it is preferable that it be in contact with other objects over the entire circumferential direction z. In other words, it is preferable that the portion of the outer surface of the dressing 100 that comes into contact with other objects extend over the entire circumferential direction z. By having the portion of the outer surface of the dressing 100 that comes into contact with other objects extend over the entire circumferential direction z, it becomes easier to adhere the dressing 100 to blood vessels and to capture airborne matter.
  • the covering material 100 preferably has a surface contact portion 101 where the outer surface of the covering material 100 comes into surface contact with another object.
  • the covering material 100 By having the covering material 100 have the surface contact portion 101, it is possible to increase the frictional force between the covering material 100 and the inner wall of a biological lumen such as a blood vessel.
  • the balloon catheter 1 is less likely to move back and forth significantly due to the blood flow caused by the pulsation of the heart, making it less likely to damage the blood vessel.
  • the surface contact portion 101 may be disposed at the distal end 100d of the covering material 100, or may be disposed proximal to the distal end 100d of the covering material 100.
  • the surface contact portion 101 is preferably disposed at the distal end of the covering material 100.
  • the balloon catheter 1 preferably further includes a shaft 70 extending in the longitudinal direction x.
  • the distal portion of the shaft 70 is connected to the balloon 10, and the fluid that inflates and deflates the balloon 10 is preferably introduced and discharged through the lumen of the shaft 70.
  • the shaft 70 is preferably made of resin, metal, or a combination of resin and metal.
  • resin as the material for the shaft 70 makes it easier to impart flexibility and elasticity to the shaft 70.
  • metal as the material for the shaft 70 can improve the deliverability of the balloon catheter 1.
  • resins that can be used to make the shaft 70 include polyamide resins, polyester resins, polyurethane resins, polyolefin resins, fluorine-based resins, vinyl chloride resins, silicone resins, natural rubber, and synthetic rubber. These may be used alone or in combination.
  • Examples of metals that can be used to make the shaft 70 include stainless steels such as SUS304 and SUS316, platinum, nickel, cobalt, chromium, titanium, tungsten, gold, Ni-Ti alloys, Co-Cr alloys, or combinations thereof.
  • the shaft 70 may also have a layered structure made of different or the same materials.
  • the balloon catheter 1 shows a so-called rapid exchange type balloon catheter 1 having a guidewire port 191 midway from the distal side to the proximal side of the shaft 70 and a guidewire tube 192 that functions as a guidewire passageway from the guidewire port 191 to the distal side of the shaft 70.
  • the balloon catheter 1 preferably has a distal shaft 75 and a proximal shaft 76, and the distal shaft 75 and the proximal shaft 76 may be separate members, with the proximal end of the distal shaft 75 connected to the distal end of the proximal shaft 76 to form the shaft 70 extending from the balloon 10 to the proximal end of the balloon catheter 1.
  • the distal shaft 75 may be formed from resin and the proximal shaft 76 may be formed from metal, for example.
  • a single shaft 70 may extend from the balloon 10 to the proximal end of the balloon catheter 1, and the distal shaft 75 and the proximal shaft 76 may be made up of multiple tubular members.
  • the present invention can also be applied to so-called over-the-wire balloon catheters, which have a guidewire passage extending from the distal to the proximal side of the shaft.
  • the balloon catheter is an over-the-wire type, it is preferable that the inflation lumen and guidewire lumen extend to a hub located on the proximal side, and that the proximal openings of each lumen be provided in a bifurcated hub.
  • the shaft 70 has a fluid flow path and a guidewire insertion path inside.
  • a guidewire tube 192 arranged inside the shaft 70 can function as the guidewire insertion path, with the space between the shaft 70 and the guidewire tube 192 functioning as a fluid flow path.
  • the guidewire tube 192 extends from the distal end of the shaft 70 and passes through the balloon 10, with the distal side of the balloon 10 connected to the guidewire tube 192 and the proximal side of the balloon 10 connected to the shaft 70.
  • the distal end of the covering material 100 is fixed to the balloon group 11, and the proximal end of the covering material 100 is fixed to the shaft 70.
  • the covering material 100 is fixed to both the balloon group 11 and the shaft 70. This allows the covering material 100 to be firmly fixed, which makes it easier to increase the efficiency of collecting scattered material by the covering material 100.
  • the covering material 100 and the balloon group 11, and the covering material 100 and the shaft 70 can be fixed, for example, by bonding with an adhesive, welding, or by fixing via another member such as attaching and crimping a ring-shaped member.
  • the shaft 70 has a guidewire lumen 93 extending in the longitudinal direction x and through which a guidewire is inserted, and further has a guidewire tube 192 having an inner cavity communicating with the guidewire lumen 93, with the guidewire tube 192 preferably being disposed in the inner cavity of the inner balloon 40. Because the balloon catheter 1 has a guidewire tube 192 having an inner cavity communicating with the guidewire lumen 93, it becomes easy to insert the guidewire into the balloon catheter 1, and the balloon catheter 1 can be transported into the body along the guidewire. Furthermore, by inserting the guidewire into the guidewire tube 192, it is possible to prevent the guidewire from damaging the balloon 10, etc.
  • the guidewire tube 192 may be made of, for example, polyolefin resins such as polyethylene and polypropylene, polyamide resins such as nylon, polyester resins such as PET, aromatic polyetherketone resins such as PEEK, polyetherpolyamide resins, polyurethane resins, polyimide resins, fluorine-containing resins such as PTFE, PFA, and ETFE, and synthetic resins such as polyvinyl chloride resins.
  • polyimide resins are preferred as the material for the guidewire tube 192.
  • Using polyimide resin as the material for the guidewire tube 192 improves the slipperiness of the guidewire tube 192.
  • the guidewire tube 192 may also have a multi-layer structure including a braided layer such as a metal braid.
  • the multi-layer structure of the guidewire tube 192 improves the strength of the guidewire tube 192, its slipperiness relative to the guidewire, and its kink resistance.
  • the proximal end of the guidewire tube 192 is preferably connected to the distal end of the shaft 70.
  • the proximal end of the guidewire tube 192 is preferably connected to the distal end of the distal shaft 75.
  • the balloon 10 and shaft 70 can be joined by bonding with an adhesive, welding, or by attaching a ring-shaped member to the overlapping portion of the end of the balloon 10 and the shaft 70 and crimping. Among these, it is preferable that the balloon 10 and the shaft 70 be joined by welding. By joining the balloon 10 and the shaft 70 by welding, the bond between the balloon 10 and the shaft 70 is less likely to come undone even when the balloon 10 is repeatedly expanded or contracted, and the bond strength can be improved.
  • a tip member 193 is preferably provided at the distal end of the balloon catheter 1.
  • the tip member 193 may be provided at the distal end of the balloon catheter 1 as a separate member from the guidewire tube 192 by being connected to the distal end of the balloon 10, or the guidewire tube 192 extending distally beyond the distal end of the balloon 10 may function as the tip member 193.
  • a radiopaque marker 194 may be placed on the guidewire tube 192 inside the balloon 10 at the portion where the balloon 10 is located in the longitudinal direction x, so that the position of the balloon 10 can be confirmed under X-ray fluoroscopy.
  • the position on the guidewire tube 192 where the radiopaque marker 194 is located may be, for example, the midpoint of the length L40 from the distal end 40d of the inner balloon 40 to the proximal end 40p of the inner balloon 40, the proximal and distal ends of the straight tube portion of the inner balloon 40, or the proximal and distal ends of the straight tube portion of the outer balloon 50.
  • the position on the guidewire tube 192 where the radiopaque marker 194 is located is preferably the proximal and distal ends of the straight tube portion of the inner balloon 40.
  • the balloon catheter 1 can be designed to easily apply pressure to the desired location.
  • a hub 5 may be provided on the proximal side of the shaft 70.
  • the hub 5 may also be provided with a fluid injection section 6 that is connected to a flow path for fluid supplied to the interior of the balloon 10.
  • the shaft 70 and hub 5 can be joined by, for example, bonding with an adhesive or welding. Among these, it is preferable that the shaft 70 and hub 5 be joined by adhesive. By joining the shaft 70 and hub 5 by adhesive, the bond strength between the shaft 70 and hub 5 can be increased, thereby improving the durability of the balloon catheter 1, even when the shaft 70 and hub 5 are made of different materials, such as when the shaft 70 is made of a highly flexible material and the hub 5 is made of a highly rigid material.
  • a coating may be applied to the outer wall of at least one of the distal shaft 75 and the proximal shaft 76, or a coating may be applied to the outer wall of both the distal shaft 75 and the proximal shaft 76. If the balloon catheter 1 is an over-the-wire type, a coating may be applied to the outer wall of the outer shaft.
  • the coating applied to the shaft 70 can be a hydrophilic or hydrophobic coating depending on the purpose, and can be applied by immersing the shaft 70 in a hydrophilic or hydrophobic coating agent, applying a hydrophilic or hydrophobic coating agent to the outer wall of the shaft 70, or covering the outer wall of the shaft 70 with a hydrophilic or hydrophobic coating agent.
  • the coating agent may contain drugs, additives, etc.
  • Hydrophilic coating agents include hydrophilic polymers such as polyvinyl alcohol, polyethylene glycol, polyacrylamide, polyvinylpyrrolidone, methyl vinyl ether maleic anhydride copolymer, and hydrophilic coating agents made from any combination thereof.
  • Hydrophobic coating agents include polytetrafluoroethylene (PTFE), fluorinated ethylene propylene (FEP), perfluoroalkoxyalkane (PFA), silicone oil, hydrophobic urethane resin, carbon coating, diamond coating, diamond-like carbon (DLC) coating, ceramic coating, and substances with low surface free energy terminated with alkyl groups or perfluoroalkyl groups.
  • PTFE polytetrafluoroethylene
  • FEP fluorinated ethylene propylene
  • PFA perfluoroalkoxyalkane
  • silicone oil silicone oil
  • hydrophobic urethane resin carbon coating
  • diamond coating diamond-like carbon (DLC) coating
  • ceramic coating and substances with low surface free energy terminated with alkyl groups or perfluoroalkyl groups.
  • the balloon catheter 1 of the present invention is preferably used to expand an aortic valve, deform a biological valve placed in the heart, or destroy a biological valve.
  • the balloon catheter 1 of the present invention is preferably used for the purpose of expanding an aortic valve that has hardened due to calcification or the like, or for the purpose of deforming or destroying an artificial valve annulus of a biological valve to replace a deteriorated biological valve placed in the heart.
  • the balloon catheter 1 of the present invention is preferably used because it is easy to apply high pressure to the area where the inner balloon 40 is located, making it easy to expand a hardened aortic valve and deform or destroy a biological valve, which conventional balloon catheters were unable to sufficiently expand.
  • Balloon catheter 5 Hub 6: Fluid injection section 10: Balloon 11: Balloon group 40: Inner balloon 40d: Distal end of inner balloon 40p: Proximal end of inner balloon 50: Outer balloon 50d: Distal end of outer balloon 50p: Proximal end of outer balloon 51: First outer balloon 52: Second outer balloon 70: Shaft 75: Distal shaft 76: Proximal shaft 93: Guidewire lumen 100: Covering material 100d: Distal end of covering material 100p: Covering material Proximal end 103: enlarged diameter section 111: straight tube section 112: distal tapered section 112p: proximal end 113 of distal tapered section: proximal tapered section 113d: distal end 113p of proximal tapered section: proximal end 114 of proximal tapered section: distal sleeve section 115: proximal sleeve section 140: tubular member 191: guidewire port 192: guidewire tube 193:

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

La présente invention concerne un cathéter à ballonnet permettant de capturer une substance disséminée, telle que du calcaire, tout en dilatant une partie rétrécie et en déformant ou en détruisant une valve biologique. Un cathéter à ballonnet (1) selon la présente invention comporte un groupe de ballonnets (11) comprenant une pluralité de ballonnets (10) agencés parallèlement les uns aux autres dans la direction circonférentielle z et un matériau de recouvrement (100) disposé radialement vers l'extérieur du groupe de ballonnets (11). Les ballonnets (10) constituant le groupe de ballonnets (11) présentent une partie de tuyau droite (111), une partie effilée (112) côté distal positionnée distalement par rapport à la partie de tuyau droit (111), et une partie effilée (113) côté proximal positionnée proximalement par rapport à la partie de tuyau droit (111). Le matériau de recouvrement (100) est disposé au moins sur la partie effilée (113) côté proximal et n'est pas disposé sur la partie effilée (112) côté distal.
PCT/JP2025/004168 2024-03-18 2025-02-07 Cathéter à ballonnet Pending WO2025197347A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2024-042321 2024-03-18
JP2024042321 2024-03-18

Publications (1)

Publication Number Publication Date
WO2025197347A1 true WO2025197347A1 (fr) 2025-09-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2025/004168 Pending WO2025197347A1 (fr) 2024-03-18 2025-02-07 Cathéter à ballonnet

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WO (1) WO2025197347A1 (fr)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07227427A (ja) * 1994-02-18 1995-08-29 Nippon Zeon Co Ltd 医療用カテーテルセット
JP2004097807A (ja) * 2002-08-20 2004-04-02 Nipro Corp 血栓捕捉カテーテル
US20120209375A1 (en) * 2011-02-11 2012-08-16 Gilbert Madrid Stability device for use with percutaneous delivery systems
WO2014178198A1 (fr) * 2013-05-02 2014-11-06 テルモ株式会社 Dispositif de retrait de caillot
US20150257782A1 (en) * 2014-03-14 2015-09-17 Michael Chaim Cohn Adjustable Catheter System
JP2018536474A (ja) * 2015-11-06 2018-12-13 シー・アール・バード・インコーポレーテッドＣ Ｒ Ｂａｒｄ Ｉｎｃｏｒｐｏｒａｔｅｄ 選択的に作動可能なバルブを有する灌流バルーン
CN113440718A (zh) * 2021-06-23 2021-09-28 上海翰凌医疗器械有限公司 一种防脑栓塞式球囊扩张导管
JP2022113664A (ja) * 2021-01-25 2022-08-04 デピュイ・シンセス・プロダクツ・インコーポレイテッド 吸引及び／又は機械的抽出装置による血塊除去中に使用するための固定及び非閉塞型血管内装置

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07227427A (ja) * 1994-02-18 1995-08-29 Nippon Zeon Co Ltd 医療用カテーテルセット
JP2004097807A (ja) * 2002-08-20 2004-04-02 Nipro Corp 血栓捕捉カテーテル
US20120209375A1 (en) * 2011-02-11 2012-08-16 Gilbert Madrid Stability device for use with percutaneous delivery systems
WO2014178198A1 (fr) * 2013-05-02 2014-11-06 テルモ株式会社 Dispositif de retrait de caillot
US20150257782A1 (en) * 2014-03-14 2015-09-17 Michael Chaim Cohn Adjustable Catheter System
JP2018536474A (ja) * 2015-11-06 2018-12-13 シー・アール・バード・インコーポレーテッドＣ Ｒ Ｂａｒｄ Ｉｎｃｏｒｐｏｒａｔｅｄ 選択的に作動可能なバルブを有する灌流バルーン
JP2022113664A (ja) * 2021-01-25 2022-08-04 デピュイ・シンセス・プロダクツ・インコーポレイテッド 吸引及び／又は機械的抽出装置による血塊除去中に使用するための固定及び非閉塞型血管内装置
CN113440718A (zh) * 2021-06-23 2021-09-28 上海翰凌医疗器械有限公司 一种防脑栓塞式球囊扩张导管

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