WO2025190407A1 - Sample analysis device - Google Patents

Abstract

A sample analysis device, comprising: an incubation unit (10); and a sample dispensing and mixing unit (20), a washing unit (30), a luminescence detection unit (40) and a gripper unit (50), which are arranged at intervals around the incubation unit (10), wherein the sample dispensing and mixing unit (20), the washing unit (30) and the luminescence detection unit (40) are all located on the movement trajectory of the gripper unit (50). The problem of low testing efficiency of sample analysis devices in the prior art is solved.

Description

Sample analysis device

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to a Chinese patent application filed with the China Patent Office on March 15, 2024, with application number 202420521545.6 and application name “Sample Analysis Device,” the entire contents of which are incorporated herein by reference.

Technical Field

The present application relates to the technical field of medical testing equipment, and in particular to a sample analysis device.

Background Art

Chemiluminescent immunoassay systems utilize the principles of chemiluminescence and immune reactions to correlate light signals with the concentration of the analyte, analyzing the analyte content in the sample. Due to their high sensitivity, specificity, and wide linear range, they are gaining increasing popularity. As the number of specimens tested increases, clinical laboratories are placing increasing demands on the volume and test throughput (throughput per unit area) of chemiluminescent immunoassay systems. Chemiluminescent immunoassay systems, however, require extremely high automation control capabilities, including sample transport, reagent storage, discharge of analytical fluids such as samples and reagents, reactor transfer, and cleaning and separation.

The test throughput of current immunoassay analyzers is no longer sufficient to meet the growing demand for testing in this field, severely impacting the efficiency of users like doctors who rely on sample measurement results for diagnosis. Furthermore, existing sample analysis devices suffer from slow testing speeds and inefficiencies; complex instrument structures, large dimensions, and slow speeds; and the need for multiple connections to increase testing speed, which occupies a large area.

Application Contents

The main purpose of this application is to provide a sample analysis device to at least solve the problem of low testing efficiency of sample analysis devices in related technologies.

In order to achieve the above-mentioned purpose, according to one aspect of the present application, a sample analysis device is provided, comprising an incubation unit and a sample adding and mixing unit, a cleaning unit, a photometric unit, and a gripper unit arranged at intervals around the incubation unit, and the sample adding and mixing unit, the cleaning unit, and the photometric unit are all located on the motion trajectory of the gripper unit.

In one embodiment, at least two of the washing unit, the light measuring unit, and the sample adding and mixing unit are located on the first side of the incubation unit.

In one embodiment, the cleaning unit is located between the sample adding and mixing unit and the light measuring unit; or, the light measuring unit is located between the sample adding and mixing unit and the cleaning unit.

In one embodiment, the sample analysis device further includes a reaction cup loading unit, which is located on the outer peripheral side of the incubation unit and upstream of the sample adding and mixing unit. The reaction cup loading unit is located on the motion trajectory of the gripper unit to provide reaction cups to the sample adding and mixing unit.

In one embodiment, the incubation unit is a fixed structure.

In one embodiment, the sample analysis device also includes a cup-throwing slide, which is located on the outer peripheral side of the incubation unit and downstream of the light measuring unit. The cup-throwing slide is located on the motion trajectory of the gripper unit, so that the gripper unit can grab the reaction cup that has been measured at the light measuring unit to the cup-throwing slide.

In one embodiment, the sample analysis device further comprises a waste collection unit, which is located downstream of the cup throwing slide and on a side of the gripper unit away from the incubation unit.

In one embodiment, the reaction cup loading unit, the gripper unit, and the cup throwing slide are located on the second side of the incubation unit, and the gripper unit is located between the reaction cup loading unit and the cup throwing slide, wherein the second side is arranged opposite to the first side.

In one embodiment, at least two of the reaction cup loading unit, the gripper unit, and the cup throwing slide are located on the second side of the incubation unit, and the second side is arranged opposite to the first side.

In one embodiment, the sample analysis device further comprises a sample reagent unit, which is located on a side of the sample adding and mixing unit away from the incubation unit. The sample reagent unit's sample adding needle system is used to add samples and/or reagents to the reaction cup at the sample adding and mixing unit.

In one embodiment, the sample reagent unit further includes a sample tray and a reagent tray, both of which are rotatable and concentrically arranged, and the sample tray is located on the outer periphery of the reagent tray; or, the sample tray and the reagent tray, both of which are rotatable and concentrically arranged, and the reagent tray is located on the outer periphery of the sample tray.

In one embodiment, the sample analysis device further includes a reagent storage unit, which is located on a second side of the incubation unit, and the second side is opposite to the first side.

In one embodiment, the incubation unit is in a matrix structure, and the incubation unit has a reaction incubation area and a substrate incubation area.

In one embodiment, the cleaning unit has an operating position M1 on a side facing the incubation unit; and/or the light measuring unit has an operating position M2 on a side facing the incubation unit.

By applying the technical solution of the present application, since the sample adding and mixing unit, the cleaning unit, and the photometric unit are all located on the motion trajectory of the gripper unit, the gripper unit can grab the reaction cup that has been mixed at the sample adding and mixing unit and transport it to the incubation unit, the cleaning unit, and the photometric unit for incubation, cleaning, photometric, and other operations respectively; in addition, by arranging the sample adding and mixing unit, the cleaning unit, the photometric unit, and the gripper unit at intervals around the incubation unit, the overall structure of the sample analysis device is ensured to be compact, thereby avoiding the sample analysis device from occupying a large installation space. Furthermore, since the overall structure of the sample analysis device provided by the present application is relatively compact, the scheduling time of the gripper unit is effectively shortened, which is conducive to improving the test speed of the sample analysis device, and the overall structure of the sample analysis device is relatively simple, and does not require the use of an additional transfer mechanism, which is conducive to reducing the cost of the sample analysis device.

BRIEF DESCRIPTION OF THE DRAWINGS

The drawings that constitute part of this application are used to provide a further understanding of this application. The illustrative embodiments of this application and their descriptions are used to explain this application and do not constitute an improper limitation on this application. In the drawings:

FIG1 shows a schematic structural diagram of a sample analysis device from a top view according to an optional embodiment of the present application.

The above drawings include the following reference numerals:
10. Incubation unit; 20. Sample adding and mixing unit; 30. Cleaning unit; 40. Photometry unit; 50. Gripping unit;
60. Reaction cup loading unit; 61. Reaction cup silo; 62. Reaction cup loading tray;
70. Cup throwing slide; 80. Waste collection unit;
90. Sample reagent unit; 91. Sample needle system; 911. Cleaning tank; 92. Sample tray; 93. Reagent tray;
100. Reagent storage unit.

DETAILED DESCRIPTION

The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. The following description of at least one exemplary embodiment is actually only illustrative and is in no way intended to limit the present application and its application or use. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

In order to solve the problem of low testing efficiency of sample analysis devices in related technologies, the present application provides a sample analysis device.

As shown in Figure 1, the sample analysis device includes an incubation unit 10 and a sample adding and mixing unit 20, a cleaning unit 30, a photometric unit 40, and a gripper unit 50 arranged at intervals around the incubation unit 10, and the sample adding and mixing unit 20, the cleaning unit 30, and the photometric unit 40 are all located on the motion trajectory of the gripper unit 50.

By applying the technical solution of the present application, since the sample adding and mixing unit 20, the cleaning unit 30, and the photometric unit 40 are all located on the motion trajectory of the gripper unit 50, the gripper unit 50 can grab the reaction cup after mixing at the sample adding and mixing unit 20 and transport it to the incubation unit 10, the cleaning unit 30, and the photometric unit 40 for incubation, cleaning, photometric and other operations respectively; in addition, by arranging the sample adding and mixing unit 20, the cleaning unit 30, the photometric unit 40, and the gripper unit 50 at intervals around the incubation unit 10, the overall structure of the sample analysis device is ensured to be compact, thereby avoiding the sample analysis device from occupying a large installation space. In one embodiment, since the overall structure of the sample analysis device provided by the present application is relatively compact, the scheduling time of the gripper unit 50 is effectively shortened, which is beneficial to improving the test speed of the sample analysis device, and the overall structure of the sample analysis device is relatively simple, and does not require the use of an additional transfer mechanism, which is beneficial to reducing the cost of the sample analysis device.

Optionally, at least two of the cleaning unit 30, the photometry unit 40, and the sample adding and mixing unit 20 are located on the first side of the incubation unit 10. In this way, the above arrangement ensures the compactness of the overall structure of the sample analysis device while also ensuring that the gripping path of the gripper unit 50 can be shortened as much as possible.

As shown in Figure 1, the cleaning unit 30 is located between the sample adding and mixing unit 20 and the light measuring unit 40. This helps to simplify the movement path of the gripper unit 50, thereby ensuring the dispatching reliability and dispatching efficiency of the gripper unit 50.

Of course, in an embodiment of the present application which is not shown in the figures, the light measuring unit 40 is located between the sample adding and mixing unit 20 and the cleaning unit 30 .

It should be noted that in the present application, the sample adding and mixing unit 20 is a mixing mechanism with multiple porous positions. The sample adding and mixing unit 20 can be used to carry the reaction cup, and to complete the addition of samples and reagents to the reaction cup at the sample adding and mixing unit 20. In addition, the sample can also be diluted and the reaction cup to which the sample and reagent are added can be mixed.

It should be noted that in the present application, in order to ensure that the gripper unit 50 does not interfere with the incubation unit 10, the sample adding and mixing unit 20, and the cleaning unit 30 when scheduling the reaction cups, the incubation unit 10, the sample adding and mixing unit 20, and the cleaning unit 30 are optionally arranged on the same horizontal plane. In this way, the reliability of the gripper unit 50 scheduling the reaction cups at the incubation unit 10, the sample adding and mixing unit 20, and the cleaning unit 30 is ensured.

As shown in FIG1 , the sample analysis device further includes a cuvette loading unit 60. The cuvette loading unit 60 is located on the outer periphery of the incubation unit 10 and upstream of the sample adding and mixing unit 20. The cuvette loading unit 60 is located on the motion trajectory of the gripper unit 50 to supply cuvettes to the sample adding and mixing unit 20. This ensures a reliable supply of cuvettes.

Furthermore, as shown in FIG1 , the cuvette loading unit 60 includes a cuvette hopper 61 and an upper cuvette tray 62. The cuvette hopper 61 is located on the side of the gripper unit 50 away from the incubation unit 10. The upper cuvette tray 62 is connected to the cuvette hopper 61 to enable the cuvette hopper 61 to transport cuvettes to the upper cuvette tray 62. The upper cuvette tray 62 is located on the motion trajectory of the gripper unit 50 to provide cuvettes to the sample loading and mixing unit 20. In this way, the cuvettes in the cuvette hopper 61 are transported to the upper cuvette tray 62 through the cooperation of the loading hopper and the loading chute. The cuvettes on the upper cuvette tray 62 are then dispatched to the sample loading and mixing unit 20 by the gripper unit 50 for sample and/or reagent addition.

As shown in FIG1 , the sample analysis device further includes a cup-throwing slide 70, which is located on the outer periphery of the incubation unit 10 and downstream of the photometric unit 40. The cup-throwing slide 70 is located on the motion trajectory of the gripper unit 50, so that the gripper unit 50 can grab the cuvette after light measurement at the photometric unit 40 and place it on the cup-throwing slide 70. The sample analysis device further includes a waste collection unit 80, which is located downstream of the cup-throwing slide 70 and on the side of the gripper unit 50 away from the incubation unit 10. Thus, the provision of the cup-throwing slide 70 serves to guide the cuvette after light measurement, thereby ensuring that the cuvette after light measurement can slide smoothly through the cup-throwing slide 70 and into the waste collection unit 80.

It should be noted that the gripper unit 50 provided in the present application is a three-dimensional gripper unit. Thus, the gripper unit 50 provided in the present application can realize the transfer and scheduling of the reaction cup between the sample adding and mixing unit 20, the incubation unit 10, the cleaning unit 30, the photometry unit 40, the reaction cup loading unit 60, and the cup throwing slide 70.

Optionally, the incubation unit 10 provides a constant temperature reaction site for the sample and reagent reaction solution, the cleaning unit 30 is used to clean the excess substances in the reaction solution and retain the test substance. The light measuring unit 40 is used to detect the light intensity of the final reaction between the test substance and the substrate luminescent solution.

Preferably, the cleaning unit 30 is a magnetic cleaning unit, which includes parts such as magnetic separation liquid injection, magnetic separation mixing, and magnetic separation liquid absorption.

Preferably, the light measuring unit 40 has a light measuring device for measuring the intensity of light emitted by the reaction.

As shown in Figure 1, the cuvette loading unit 60, gripper unit 50, and cup-throwing slide 70 are located on the second side of the incubation unit 10, with the gripper unit 50 positioned between the cuvette loading unit 60 and the cup-throwing slide 70, with the second side being positioned opposite the first side. This arrangement allows the cuvette loading unit 60, cup-throwing slide 70, and incubation unit 10 to be arranged around the gripper unit 50. Simultaneously, the aforementioned sample loading and mixing unit 20, cleaning unit 30, and photometry unit 40 are spaced apart around the incubation unit 10, fully utilizing the installation space. This allows for a compact layout of the various components of the sample analyzer, resulting in a low-cost overall layout. This eliminates the need for additional transfer mechanisms, significantly shortens the dispatch time of the gripper unit 50, and thus improves the testing efficiency of the sample analyzer.

Of course, in an embodiment not shown in the figures of the present application, at least two of the cuvette loading unit 60, the gripper unit 50, and the cup throwing slide 70 may be located on the second side of the incubation unit 10, with the second side being disposed opposite the first side. This can also shorten the dispatching time of the gripper unit 50, thereby improving the testing efficiency of the sample analysis device.

As shown in FIG1 , the sample analysis device further includes a sample reagent unit 90, which is located on a side of the sample adding and mixing unit 20 away from the incubation unit 10. The sample adding needle system 91 of the sample reagent unit 90 is used to add samples and/or reagents to the reaction cup at the sample adding and mixing unit 20. Thus, the sample reagent unit 90 provided in the present application can be used to add a sample of a substance to be detected to the reaction cup at the sample adding and mixing unit 20, and can also be used to add the reagents required for detecting the content of the substance to be detected in the sample at the reaction cup at the sample adding and mixing unit 20, thereby saving the overall structural components of the sample analysis device and facilitating the compactness of the overall structure of the sample analysis device.

As shown in FIG. 1 , the sample adding needle system 91 has at least one cleaning tank 911 .

As shown in FIG1 , the sample and reagent unit 90 further includes a sample tray 92 and a reagent tray 93. Both the sample tray 92 and the reagent tray 93 are rotatable and concentrically arranged, with the sample tray 92 positioned on the outer periphery of the reagent tray 93. Alternatively, both the sample tray 92 and the reagent tray 93 are rotatable and concentrically arranged, with the reagent tray 93 positioned on the outer periphery of the sample tray 92. Thus, by making the sample tray 92 and the reagent tray 93 rotatable and concentrically arranged, the installation space is fully utilized while further ensuring the compactness of the overall structure of the sample analyzer.

It should be noted that, in the present application, the sample disk 92 and the reagent disk 93 rotate independently, and the rotations of the two do not interfere with each other.

As shown in Figure 1, the sample analysis device further includes a reagent storage unit 100, which is located on the second side of the incubation unit 10, the second side being opposite the first side. Thus, the reagent storage unit 100 is used to store reagents for detecting the content of a substance to be tested in a sample, and can store a variety of different reagents, such as conventional reagents, diluents, pretreatment solutions, and enhanced cleaning solutions.

In one embodiment, the incubation unit 10 is a fixed structure, so that the incubation unit 10 in the present application is a fixed incubation unit 10 .

In one embodiment, the incubation unit 10 is in a matrix structure, and the incubation unit 10 has a reaction incubation area and a substrate incubation area.

It should be noted that in the present application, to ensure the reliability of the gripper unit 50 in manipulating the cuvette, as shown in FIG1 , the cleaning unit 30 has an operating position M1 on the side facing the incubation unit 10, and/or the photometric unit 40 has an operating position M2 on the side facing the incubation unit 10. This facilitates the gripper unit 50 to move to the operating position M1 to maneuver the cuvette, and facilitates the gripper unit 50 to move to the operating position M2 to maneuver the cuvette.

It should be noted that in the present application, in order to enable a test to be carried out completely, the sample analysis device in the present application also includes a consumables loading unit and a control unit. The sample reagent unit 90 provides a continuous supply of samples to be tested for the test, realizing automatic continuous testing of samples. The sample rack is a carrier for holding samples. The sample rack containing the samples to be tested is dispatched by the sample tray unit, thereby transferring the samples to the designated sample suction position on the sample tray 92 located under the motion trajectory of the sample injection needle system 91. The consumables loading unit is used to load the substrate liquid, cleaning liquid, diluent and other consumables required for the test reaction. The control unit is used to control the actions of the various moving parts required to complete the test and the timing of the periodic coordinated work.

In a specific embodiment of the present application, the one-step operation process of the automatic sample analysis device is as follows:

1. The sample tray unit transfers the sample rack containing the sample to be tested to the sample aspiration position of the sample tray 92 through scheduling.

2. The gripper unit 50 transfers a cuvette on the upper cuvette tray 62 of the cuvette loading unit 60 to the sample adding and mixing unit 20 .

3. The sample adding needle system 91 of the sample reagent unit 90 draws a certain amount of sample from the sample aspirating position and discharges it into the reaction cup of the sample adding and mixing unit 20 .

4. The reagent tray 93 dispatches the reagent kits required for the test items to the reagent sampling port, making it easier for the sample injection system 91 to absorb the reagents.

5. The sample adding needle system 91 draws a certain amount of reagent from the reagent sample aspirating port of the reagent disk 93 and discharges it into the sample adding and mixing unit 20 .

6. The sample adding and mixing unit 20 mixes the reaction solution.

7. The gripper unit 50 transfers the reaction cup to the incubation well of the reaction incubation area of the incubation unit 10 for incubation of the reaction solution.

9. After a period of time, when the reaction solution incubation is completed, the gripper unit 50 transfers the reaction cup to the cleaning unit 30 for magnetic cleaning.

10. After the magnetic cleaning is completed, when substrate incubation is not required, the gripper unit 50 directly transfers the reaction cup to the photometric unit 40 for subsequent photometric operations.

11. After magnetic cleaning, if substrate incubation is required, the gripper unit 50 transfers the cuvette to the incubation well of the substrate incubation area of the incubation unit 10 to incubate the cleaned substrate again. After a period of time, when substrate incubation is complete, the gripper unit 50 transfers the cuvette to the photometry unit 40 for subsequent photometry.

12. After the cuvette has been tested, the light measuring unit 40 moves the cuvette to the operating position, and the gripper unit 50 transfers it to the cup throwing slide 70 for cup throwing, thus completing the entire test.

To implement a two-step process, based on the one-step process described above, after the magnetic cleaning is completed, the gripper unit 50 transfers the cuvette to the sample adding and mixing unit 20 again for the second step of reagent addition. Subsequent actions are the same as the one-step process of this test.

For sample dilution, automatic dilution, or multiple dilution processes, based on the aforementioned one-step method, after the reaction solution is mixed in the sample adding and mixing unit 20, the sample adding needle system 91 aspirates the diluted sample from the reaction cup in the sample adding and mixing unit 20. The sample adding needle system 91 can aspirate the sample multiple times from the same reaction cup in the sample adding and mixing unit 20. Subsequent steps follow the same one-step method for this test.

It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprise" and/or "include" are used in this specification, they indicate the presence of features, steps, operations, devices, components and/or combinations thereof.

Unless otherwise specifically stated, the relative arrangement of the parts and steps, numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present application. At the same time, it should be understood that, for ease of description, the sizes of the various parts shown in the drawings are not drawn according to actual proportional relationships. The techniques, methods and equipment known to those of ordinary skill in the relevant art may not be discussed in detail, but where appropriate, the techniques, methods and equipment should be considered as part of the authorization specification. In all examples shown and discussed here, any specific values should be interpreted as being merely exemplary and not as limitations. Therefore, other examples of the exemplary embodiments may have different values. It should be noted that similar numbers and letters represent similar items in the following figures, and therefore, once an item is defined in one figure, it does not need to be further discussed in subsequent figures.

For ease of description, spatially relative terms such as "above", "above", "on the upper surface of", "above", etc. may be used herein to describe the spatial positional relationship of a device or feature to other devices or features as shown in the figures. It should be understood that spatially relative terms are intended to include different orientations of the device in use or operation in addition to the orientation described in the figures. For example, if the device in the drawings is inverted, the device described as "above other devices or structures" or "above other devices or structures" will be positioned as "below other devices or structures" or "below other devices or structures". Thus, the exemplary term "above" can include both "above" and "below". The device can also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatially relative descriptions used here are interpreted accordingly.

It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprise" and/or "include" are used in this specification, they indicate the presence of features, steps, tasks, devices, components and/or combinations thereof.

It should be noted that the terms "first," "second," and the like in the specification and claims of this application and the accompanying drawings are used to distinguish similar objects and are not necessarily used to describe a specific order or precedence. It should be understood that the terms used in this manner are interchangeable where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than that illustrated or described herein.

The above description is merely a preferred embodiment of the present application and is not intended to limit the present application. Various modifications and variations are possible for those skilled in the art. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present application shall be included within the scope of protection of the present application.

Claims (14)

A sample analysis device, comprising: An incubation unit (10) and a sample adding and mixing unit (20), a cleaning unit (30), a photometric unit (40), and a gripper unit (50) are arranged at intervals around the incubation unit (10), and the sample adding and mixing unit (20), the cleaning unit (30), and the photometric unit (40) are all located on a motion trajectory of the gripper unit (50). The sample analysis device according to claim 1, characterized in that at least two of the cleaning unit (30), the light measuring unit (40), and the sample adding and mixing unit (20) are located on the first side of the incubation unit (10). The sample analysis device according to claim 1 or 2, characterized in that The cleaning unit (30) is located between the sample adding and mixing unit (20) and the light measuring unit (40); or, The light measuring unit (40) is located between the sample adding and mixing unit (20) and the cleaning unit (30). The sample analysis device according to claim 2, further comprising: A reaction cup loading unit (60) is located on the outer peripheral side of the incubation unit (10) and upstream of the sample adding and mixing unit (20). The reaction cup loading unit (60) is located on the motion trajectory of the gripper unit (50) to provide reaction cups to the sample adding and mixing unit (20). The sample analysis device according to claim 4, characterized in that the incubation unit (10) is a fixed structure. The sample analysis device according to claim 4, further comprising: A cup throwing slide (70), the cup throwing slide (70) is located on the outer peripheral side of the incubation unit (10) and downstream of the light measuring unit (40), and the cup throwing slide (70) is located on the motion trajectory of the gripper unit (50), so that the gripper unit (50) can grab the reaction cup after the light is measured at the light measuring unit (40) and place it on the cup throwing slide (70). The sample analysis device according to claim 6, characterized in that the sample analysis device further comprises: A waste collection unit (80) is located downstream of the cup throwing slide (70) and on a side of the gripper unit (50) away from the incubation unit (10). The sample analysis device according to claim 6 is characterized in that the reaction cup loading unit (60), the gripper unit (50), and the cup throwing slide (70) are located on the second side of the incubation unit (10), and the gripper unit (50) is located between the reaction cup loading unit (60) and the cup throwing slide (70), wherein the second side is arranged opposite to the first side. The sample analysis device according to claim 6 is characterized in that at least two of the reaction cup loading unit (60), the gripper unit (50), and the cup throwing slide (70) are located on the second side of the incubation unit (10), and the second side is arranged opposite to the first side. The sample analysis device according to any one of claims 4 to 9, characterized in that the sample analysis device further comprises: A sample reagent unit (90) is located on a side of the sample adding and mixing unit (20) away from the incubation unit (10), and a sample adding needle system (91) of the sample reagent unit (90) is used to add samples and/or reagents to a reaction cup at the sample adding and mixing unit (20). The sample analysis device according to claim 10, characterized in that the sample reagent unit (90) further comprises: A sample disk (92) and a reagent disk (93), wherein the sample disk (92) and the reagent disk (93) are both rotatable and concentrically arranged, and the sample disk (92) is located on the outer peripheral side of the reagent disk (93); or, A sample disk (92) and a reagent disk (93) are both rotatable and concentrically arranged, and the reagent disk (93) is located on the outer peripheral side of the sample disk (92). The sample analysis device according to claim 2, further comprising: A reagent storage unit (100), wherein the reagent storage unit (100) is located on a second side of the incubation unit (10), and the second side is arranged opposite to the first side. The sample analysis device according to claim 1, characterized in that the incubation unit (10) is in a matrix structure, and the incubation unit (10) has a reaction incubation area and a substrate incubation area. The sample analysis device according to claim 1, wherein The cleaning unit (30) has an operating position M1 on a side facing the incubation unit (10); and/or, The light measuring unit (40) has an operating position M2 on a side facing the incubation unit (10).