[go: up one dir, main page]

WO2025188770A8 - System and method for automated insulin delivery using artificial neural network - Google Patents

System and method for automated insulin delivery using artificial neural network

Info

Publication number
WO2025188770A8
WO2025188770A8 PCT/US2025/018364 US2025018364W WO2025188770A8 WO 2025188770 A8 WO2025188770 A8 WO 2025188770A8 US 2025018364 W US2025018364 W US 2025018364W WO 2025188770 A8 WO2025188770 A8 WO 2025188770A8
Authority
WO
WIPO (PCT)
Prior art keywords
neural network
ssm
bps
insulin delivery
saturated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2025/018364
Other languages
French (fr)
Other versions
WO2025188770A1 (en
Inventor
Marc D. Breton
Marcela MOSCOSO-VASQUEZ
Patricio COLMEGNA
Alberto Castillo FRASQUET
Jenny Lorena DIAZ-CASTAÑEDA
Maria Fernanda VILLA TAMAYO
Elliott Carroll PRYOR
Anas EL FATHI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UVA Licensing and Ventures Group
Original Assignee
University of Virginia Patent Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Virginia Patent Foundation filed Critical University of Virginia Patent Foundation
Publication of WO2025188770A1 publication Critical patent/WO2025188770A1/en
Publication of WO2025188770A8 publication Critical patent/WO2025188770A8/en
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Business, Economics & Management (AREA)
  • Business, Economics & Management (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Endocrinology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

An automated insulin delivery system provides an insulin injection that is computed by adding (i) the recommendation of an artificial neural network trained to mimic a constrained model predictive controller dosing rule from a neural network implementing an artificial pancreas (ii) a hypoglycemia mitigation system includeds a correction (one dose computed as the correction down to 110mg/dl based on prevailing continuous glucose monitoring and once an hour at most, unless there is a triggering BPS and G>180 mg/dl), and (iii) the current basal rate (output of the Performance Assessment System, (PAS)); that amount is then saturated by the Safety Supervision System, SSM. Finally, a priming bolus from the Bolus Priming System, BPS, is added to the total if the conditions for large glycemic excursions are detected, also saturated by SSM.
PCT/US2025/018364 2024-03-04 2025-03-04 System and method for automated insulin delivery using artificial neural network Pending WO2025188770A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202463560982P 2024-03-04 2024-03-04
US63/560,982 2024-03-04

Publications (2)

Publication Number Publication Date
WO2025188770A1 WO2025188770A1 (en) 2025-09-12
WO2025188770A8 true WO2025188770A8 (en) 2025-10-02

Family

ID=96991581

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2025/018364 Pending WO2025188770A1 (en) 2024-03-04 2025-03-04 System and method for automated insulin delivery using artificial neural network

Country Status (1)

Country Link
WO (1) WO2025188770A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2399205B1 (en) * 2009-02-25 2020-04-08 University Of Virginia Patent Foundation Cgm-based prevention of hypoglycemia via hypoglycemia risk assessment and smooth reduction insulin delivery
GB2493712B (en) * 2011-08-12 2014-07-02 Gene Onyx Ltd Insulin pump
CN113101448B (en) * 2016-01-14 2024-01-23 比格福特生物医药公司 System for adjusting insulin delivery rate

Also Published As

Publication number Publication date
WO2025188770A1 (en) 2025-09-12

Similar Documents

Publication Publication Date Title
US20240165327A1 (en) Glucose control system with automatic adaptation of glucose target
CA2816314C (en) Blood glucose control system
USRE50075E1 (en) Glucose level control system with offline control based on preceding periods of online control
US9656020B2 (en) Glucagon pump controller
CN104769595B (en) Protection Technology for Closed Loop Insulin Infusion System
EP3768166A1 (en) System for predicting a patient's blood glucose level
WO2025188770A8 (en) System and method for automated insulin delivery using artificial neural network
WO2025188774A8 (en) System and method for real-time personalization of automated insulin delivery
AU2023278117A1 (en) Method and system for determining glucose change in a subject
EP3813663B1 (en) Automated system for controlling the blood sugar of a patient
CN116492539A (en) Intelligent control method for artificial pancreas and artificial pancreas system
Borri et al. Safe digital stabilization of nonlinear systems with an application to glucose control
Prud'Homme et al. Preclinically assessed optimal control of postprandial glucose excursions for type 1 patients with diabetes
CN119633202A (en) A blood sugar control system and control method based on closed-loop technology
Herrero et al. Live demonstration: A handheld bio-inspired artificial pancreas for treatment of diabetes
US20250352726A1 (en) Closed-loop blood glucose control systems and methods
US20250239350A1 (en) Insulin dosage determination system based on personalized artificial intelligence
Golestani et al. Periodic event-based regulation of blood glucose for type-1 diabetic patients in the presence of unknown actuation delay and quantization in BGC measurement and infused insulin
US20230033205A1 (en) Automated system for controlling the blood glucose level
CN117373607A (en) Adaptive closed-loop control method considering endogenous glucose production rate
CA3100244A1 (en) Automated system for monitoring a patient's blood sugar
Meriem et al. Glucose Insulin Regulation Using Backstepping Technique
AU2024209750A1 (en) Systems and methods for risk based insulin delivery conversion
CN120586207A (en) A homogeneous control method for artificial pancreas based on Lyapunov theory
Reiter et al. GLUCAGON PEN MAKES BIHORMONAL DELIVERY MORE PATIENT FRIENDLY AND ALLOWS BETTER BG CONTROL IN SPITE OF IMPRECISE MEAL ESTIMATIONS

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 25768768

Country of ref document: EP

Kind code of ref document: A1